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guanidinoacetic acid ( gaa ) occurs naturally in the human body and acts as a precursor of creatine , the latter playing an important role as an energy carrier / mediator in the cell 1 , 2 .
gaa itself along with l - ornithine is formed in an enzyme - catalyzed step from l - arginine and glycine , mainly in the kidne... | objectives ; guanidinoacetic acid ( gaa ) is a natural precursor of creatine , yet the potential use of gaa as a nutritional additive for restoring creatine availability in humans has been limited by unclear efficacy and safety after exogenous gaa administration .
the present study evaluated the effects of orally adm... |
risk - taking behaviors that can have lifelong implications are often begun in adolescence and young adulthood .
two common health - risk behaviors that are frequently initiated are cigarette smoking and the alcohol consumption .
the long - term negative health consequences of these behaviors have been well documen... | asthma is one of the most common , serious chronic diseases in pediatric and young adult populations . health - risk behaviors , including cigarette smoking and alcohol use , may exacerbate chronic diseases and complicate their management .
the aim of this study was to longitudinally analyze rates of cigarette smokin... |
recent epidemics of mosquito - borne viral infections in countries neighboring iran i.e. dengue , chikungunya and west nile infections in pakistan , dengue and rift valley fever in saudi arabia , and west nile infection in iraq ( 1 , 2 , 3 ) have placed this country at a serious risk for mosquito - borne diseases .
o... | background : epidemics of mosquito - borne viral infections such as dengue , chikungunya , west nile and rift valley fevers in neighbouring countries and risk of introduction of exotic vectors into iran have placed this country at a significant risk for these mosquito - borne diseases.methods:after the first dengue cas... |
outbred hairless mice ( mus musculus , skh-1 strain ) , originally purchased from charles river deutschland ( sulzfeld , germany ) , were bred and maintained in the laboratory .
the strain of b. afzelii originated from a naturally infected nymphal i. ricinus tick collected from vegetation in suburban berlin ( 9 ) .
... | to determine whether direct passage of spirochetes between co - feeding vector ticks contributes to the likelihood that the lyme disease spirochete borrelia afzelii will perpetuate in nature , we compared the effects of time and space on transmission efficiency between simultaneously feeding ticks .
the likelihood of... |
study area - the study was conducted in the cidade nova neighbourhood
of manaus ( 307 s 5957w ) ( fig .
manaus and cidade nova had estimated populations
of 1,802,014 and 121,135 in 2010 ( ibge 2010 ) .
the
houses of the mainly residential neighbourhood are made of wood or brick , usually with
verandas and/o... | the objective of this study was to evaluate the effectiveness of aedes
aegypti mass trapping using the sticky trap mosquitrap ( mqt ) by
performing a cluster randomised controlled trial in manaus , state of amazonas ,
brazil .
after an initial questionnaire and baseline monitoring of adult ae .
aegypti abunda... |
acute respiratory failure ( arf ) is the most common organ failure in a general intensive care unit ( icu ) , and the mortality rate is high . in a recent epidemiological study conducted in scandinavia ,
the 90-day mortality rate in arf patients was similar to those in acute respiratory distress syndrome ( ards ) and... | introductionthe incidence and outcome of acute respiratory failure ( arf ) depend on dysfunction in other organs . as a result ,
reported mortality in patients with arf is derived from a mixed group of patients with different degrees of multiorgan failure .
the main goal of the present study was to investigate pati... |
in the last decade , it has been increasingly recognized that global hiv / aids efforts often fail to address the reproductive health and specifically family planning ( fp)needs of people living with hiv .
the need for an integrated approach to reproductive health and hiv was formally acknowledged as early as the 19... | despite increasing efforts to address the reproductive health needs of people living with hiv , a high unmet need for contraception exists among hiv+ women in sub - saharan africa .
this study explores the fertility intentions and family planning ( fp ) preferences of kenyan women accessing hiv treatment .
we condu... |
diarrheal diseases are a great public health problem that leads to morbidity and mortality of infants and children particularly in developing countries and even in developed countries . in developing countries
recent conservative estimates have indicated that 702,000 children die each year from rotavirus disease and ... | diarrheal diseases are a great public health problem ; they are among the most causes leading to morbidity and mortality of infants and children particularly in developing countries and even in developed countries .
rotavirus is the most common cause of severe gastroenteritis in infants and young children in both dev... |
porous tantalum is a relatively new biomaterial in orthopedics , used in domains such as hip and knee arthroplasty , hip osteonecrosis surgery , and spine surgery.1 it consists of a carbon scaffold on which pure tantalum is deposited.23 porous tantalum possesses some unique mechanical properties,46 mainly due to its hi... | porous tantalum is a biomaterial that was recently introduced in orthopedics in order to overcome problems related to implant loosening .
it is found to have osteoconductive , and possibly , osteoinductive properties hence useful in difficult cases with severe bone defects .
so , it is of great interest to shed lig... |
warfarin , the most commonly used anticoagulant in north america , is a vitamin k antagonist that
is demonstrated to be efficacious in the prevention of thrombosis and thromboembolism .
its use dates
back to the 1950s , when it was approved as an anticoagulant in the united states.1 current indications for its us... | for many decades , the vitamin k antagonist warfarin has been the mainstay of treatment for
various conditions that require anticoagulation , including atrial fibrillation .
although the
efficacy of warfarin in both prevention and treatment of thrombosis has been demonstrated in
numerous randomized clinical stu... |
previous studies ( 15 ) suggest that 1520% of new prescriptions for medications treating elevated levels of glucose , blood pressure ( bp ) , or lipids are never filled and that only 60% of those who fill a newly prescribed medication in these classes have persisted in taking the medication 12 months later . however , ... | objectivemedication nonadherence is a major obstacle to better control of glucose , blood pressure ( bp ) , and ldl cholesterol in adults with diabetes .
inexpensive effective strategies to increase medication adherence are needed.research design and methodsin a pragmatic randomized trial , we randomly assigned 2,378... |
epilepsy is characterized by spontaneous recurrent seizures and comprises a diverse group of syndromes with different aetiologies .
epilepsy is the second most common brain disorder , affecting about 1% of the world 's population .
temporal lobe epilepsy ( tle ) remains as one of the most severe and frequent pharma... | synaptic plasticity is the capacity generated by experience to modify the neural function and , thereby , adapt our behaviour .
long - term plasticity of glutamatergic and gabaergic transmission occurs in a concerted manner , finely adjusting the excitatory - inhibitory ( e / i ) balance .
imbalances of e / i funct... |
low back pain is a very frequent symptom at general orthopaedic consultation , and establishes a long term chronic illness between 2% and 7% of times . although , a great majority of the chronic low back pain is related to vertebral degenerative pathology , other possible reasons , even unusual , have to been considere... | highlightslow back pain is a common cause of medical consultation , and usually supposes a non - malignant prognostic.we report an abdominal aortic aneurism ( aaa ) as atypical etiology of low back pain.we should consider aaa as other cause of low back pain and routinely examine the abdomen and seek complementary imagi... |
endometriosis , a common polygenic / multifactorial disease , might be caused by an interaction between multiple genes as well as the environment 1 .
endometriosis displays features similar to malignancy , including local invasion and aggressive spread to distant organs .
tumor suppressor genes play a role in the r... | objective : mutated p53 gene is related to the instability of cell growth and cell cycle progression .
we aimed to evaluate the association between endometriosis and p53 codon 11 , 72 and 248 gene polymorphisms.patients and methods : women were divided into two groups : ( 1 ) moderate / severe endometriosis ( n=148 )... |
a number of electron microphotographs are presented showing the various aspects of phagocytosis of fibers in lung tissue .
the fibers were rapidly phagocytosed by alveolar macrophages , by polymorphonuclear leucocytes , and less frequently by alveolar epithelial cells .
they were also found in the cytoplasm of the ... | |
to describe a visually evoked potential ( vep ) examination performed on a patient with a keratoprosthesis .
we report the case of a 60-year - old patient with a fyodorov - zuev keratoprosthesis in the right eye complained of gradual visual deterioration in that eye . his past medical history consisted of failed corn... | purposeto describe a visually evoked potential ( vep ) examination performed on a patient with a keratoprosthesis.methodswe report the case of a 60-year - old patient with a fyodorov - zuev keratoprosthesis in the right eye complained of gradual visual deterioration in that eye .
his past medical history consisted of... |
the birth of a child is a major life event that can be filled with excitement , anticipation , and joy .
however , the transition and adaptation to new demands , roles , responsibilities , and changes in relationships can be stressful , especially for first - time mothers .
in addition , new mothers typically enc... | psychological distress , defined as depression , anxiety , and insomnia in this study , can occur following the birth of a baby as new mothers , in addition to marked physiological changes , are faced with adapting to new roles and responsibilities .
we investigated the cooccurrence of stress , depression , anxiety ,... |
most tumors in lower female genital area are originated from vaginal or urethral mucosa ( 1 , 2 ) .
mostly , they are accompanied by apparent symptoms , such as vaginal bleeding or hematuria , which lead to an easy detection of the tumor ( 2 ) . however , the mass developed at urethrovaginal septum without definite i... | primary endometrioid adenocarcinoma developed at urethrovaginal septum has not been reported .
a 61-yr - old woman presented with recurrent urinary tract infection .
she had received hormone replacement treatment with estrogen and progesterone for 5 yr .
a pinpoint ulceration at slightly elevated anterior vaginal... |
hyperkalemia is a serious medical condition that can cause muscle weakness , paralysis , and cardiac arrhythmias and is associated with increased mortality.13 defined as serum potassium greater than 5 meq / l ( 5 mmol / l ) , hyperkalemia is rare in the general population because the renal system tightly regulates pota... | introductionhyperkalemia is a serious medical condition that often manifests in patients with chronic kidney disease and heart failure .
renin
angiotensin
aldosterone system inhibitors are known to improve outcomes in these disease states but can also cause drug - induced hyperkalemia .
new therapeutic options ... |
peritoneal metastases from lung cancer are a rare event . in this paper , we report the case of a patient with adenocarcinoma of the lungs who had isolated peritoneal metastases at the time of diagnosis .
we report a 55-year - old female who presented with shortness of breath , decreased effort tolerance , cough , an... | introductionperitoneal metastases from lung cancer are a rare event . in this paper
, we report the case of a patient with adenocarcinoma of the lungs who had isolated peritoneal metastases at the time of diagnosis.case reportwe report a 55-year - old female who presented with shortness of breath , decreased effort t... |
different jaw regions exhibit different bone densities , which might be under the influence of various factors , including osteoporosis .
osteoporosis is the most common metabolic bone disorder , which is characterized by a decrease in bone mineral density ( bmd ) or changes in the bone microstructure .
bmd is a me... | background : the aim of the present study was to evaluate the relationship between the bone density of various regions of jaws and skeletal bones.materials and methods : a total of 110 patients with a mean age of 55.01 10.77 years were selected for the purpose of the present descriptive study .
dual x - ray energy a... |
a 66-year - old woman with recently diagnosed durie and salmon stage iiib igg kappa myeloma was started on cybord chemotherapy including cyclophosphamide 500 mg orally weekly , bortezomib ( given weekly after hemodialysis , at a dose of 2.5 mg subcutaneously ) , and dexamethasone 2040 mg orally weekly , having failed p... | chemotherapy - associated cardiotoxicity can present as a spectrum from arrhythmia to acute congestive heart failure . unlike anthracyclines , proteasome inhibitors for example , bortezomib are not notorious for causing cardiotoxicity in absence of pre - existing cardiac dysfunction or without concomitant use of othe... |
acute exacerbations of chronic obstructive pulmonary disease ( copd ) account for a considerable number of acute medical admissions , with the majority being admitted through the emergency department ( ed ) .
there were 10,863 admissions in ireland for copd in 2010 , which account for 2.3% of all hospital inpatients ... | aimto determine the efficacy and usefulness of a chronic obstructive pulmonary disease ( copd ) care bundle designed for the initial management of acute exacerbations of copd and to assess whether it improves quality of care and provides better outcomes.introductionthe level of care provided in the emergency department... |
a detailed understanding of the anterior cruciate ligament ( acl ) is the basis for anatomical acl reconstruction .
many cadaver studies have been performed to evaluate its midsubstance size and shape and its tibial insertion in the fossa of the area intercondylaris anterior .
most authors described the tibial acl ... | purpose
this anatomical cadaver study was performed to investigate the flat appearance of the midsubstance shape of the anterior cruciate ligament ( acl ) and its tibial c-shaped insertion site.methodsthe acl midsubstance and the tibial acl insertion were dissected in 20 cadaveric knees ( n = 6 fresh frozen and n ... |
autism is a relatively common and heterogeneous neuropsychiatric disorder characterised
by reduced social and interindividual contacts and interactions .
complete absence of eye contact and speech can be
observed in severe forms of autism .
its incidence is estimated at about
1/1000 to 1/2000 with a biased ma... | the high incidence of de novo chromosomal aberrations in a population of persons with autism suggests a causal relationship between certain chromosomal aberrations and the occurrence of isolated idiopathic autism .
we report on the clinical and cytogenetic findings in a male patient with autism , no physical abnormal... |
the us health care delivery system is comprised of at least five components : cost , quality , accessibility , maintenance of the medical education system , and availability of a well trained physician workforce , all of which are being threatened by major challenges.1 among these challenges is the high cost of health ... | currently , in the united states there is a significant physician workforce shortage .
this problem is likely to persist as there is no quick solution .
the nature of this shortage is complex and involves factors such as an absolute physician shortage , as well as physician shortages in primary care and certain spe... |
the aging population in malaysia has significantly increased in number over the last few decades .
it is imperative to perform extensive research to provide evidence - based strategies for successful aging.1 aging affects many domains of cognitive performance.2 even though evidence indicates that age - related cognit... | purposecognitive impairment is correlated with physical function . however
, the results in the literature are inconsistent with cognitive and physical performance measures .
thus , the aim of this study was to determine the association between cognitive performance and physical function among older adults.methodsa... |
the classical predator - prey model based on the logistic growth principle and hollings predation theory is as follows : ( 1)dxdt = x(1xk)axy1+chx , dydt = bxy1+chxdy ,
where x and y represent the density of prey and predator species with carrying capacity k. the constant a denotes the food intake rate of predator , ... | a predator - prey model in presence of alternative prey is proposed .
existence and local stability conditions for interior equilibrium points are derived . global stability conditions for interior equilibrium points are also found .
bifurcation analysis is done with respect to predator 's searching rate and handli... |
an incidence of 20 - 25% in sexually active and 30 - 35% in all women irrespective of age has been reported .
the surgical management of myomas has advanced significantly , there has been a renewed interest in the removal of myoma alone , i.e. , myomectomy rather than hysterectomy , which was carried out historically... | objective : to assess the feasibility and outcome of laparoscopic myomectomy and multiple layer closure of myoma bed for management of myomas at a tertiary care hospital.materials and methods : four hundred and seventeen patients from september 2005 to september 2010 with large and moderate size myomas were managed by ... |
viral hepatitis affects millions of people worldwide , with over 20 million people diagnosed with acute infections annually and over 150 million with chronic viral hepatitis ( http://www.who.int/mediacentre/factsheets/fs328/en/ , http://www.who.int/mediacentre/factsheets/fs204/en/ , http://www.who.int/mediacentre/facts... | acute viral hepatitis affects all ages worldwide .
hepatitis e virus ( hev ) is increasingly recognized as a major cause of acute hepatitis in europe . because knowledge of its characteristics is limited
, we conducted a retrospective study to outline demographic and clinical features of acute hev in comparison to ... |
terminal deoxynucleotidyl transferase ( tdt)-mediated dutp nick end - labeling ( tunel ) kits were purchased from nanjing keygen biotech co. , ltd . , nanjing , china .
anti - puma , anti - caspase-3 primary antibodies and streptavidin - biotin - peroxidase complex ( sabc ) immunohistological staining kits ( sa1022 )... | objectives : to assess the effects of nerve growth factor ( ngf ) on motor neurons after induction of a facial nerve lesion , and to compare the effects of different routes of ngf injection on motor neuron survival.methods:this study was carried out in the department of otolaryngology head & neck surgery , china medica... |
flies are pests of great medical and veterinary significance and are one of the most important vectors of human diseases worldwide [ 1 , 2 ] .
houseflies are important nuisance pests of domestic animals and people , as well as the main fly vectors of foodborne and animal pathogens .
due to their indiscriminate mo... | this study aims to evaluate flies as a vector for foodborne pathogens . for this purpose ,
several flies were collected from different sites from rural areas .
these flies were then analyzed for the presence of enterobacteriaceae , escherichia coli , staphylococcus coagulase positive , and listeria monocytogenes . ... |
this disease has been already reported in usa 's middle west and northeast ; latin america , asia , africa and several cases with no etiological confirmation in europe .
histoplasmosis is the most prevalent mycosis disseminated in central america , united states ( ohio and mississippi ) and mexico 's southeast .
al... | in this study , we report four cases of histoplasma capsulatum infection in eight biologists who made an expedition to determine the prevalence of this fungus in a cave localized in the northwest of minas gerais state , brazil .
this case report demonstrates the importance of evaluating the h. capsulatum presence in ... |
low bone mineral density ( bmd ) has long been established as an important risk factor for hip fracture or lumbar fracture .
it follows that knowledge of the other factors , such as obesity , smoking , alcohol intake , drugs intake , and long - term bed rest , influencing bmd is crucial for preventing and treating os... | the relationship between adipose and bone tissues is still being debated .
the purpose of our study was to evaluate whether the distribution and volume of abdomen adipose tissue are correlated to trabecular bone mineral density in the lumbar spine . in this cross - sectional study ,
320 chinese women , being divide... |
research examining the link between work - family conflict ( wfc : when work and family roles conflict with each other ) and alcohol use has generally found the strength of the relationship between these variables to be small ( see ) .
this may be due to a general failure to examine individual differences ( other tha... | research on the relationship between work - family conflict and alcohol use has generally shown small effects possibly due to failure to include important individual differences relevant to the experience of work - family conflict and alcohol use , notably age .
this study examined whether the relationships between a... |
orofacial clefts , and in particular cleft lip and palate , are major human birth defects with complex etiology . the cleft face has been studied extensively . however , the results reported in literature vary and sometimes are in disagreement .
the reason for differences includes different treatment procedures for t... | objective : the aim of this cross - sectional study was to compare craniofacial growth among operated and unoperated unilateral cleft lip and palate non - syndromic subjects.materials and methods : a sample of 180 subjects of indian origin was selected . of them ,
90 were operated , and 90 were unoperated complete un... |
the pig farm , a closed farrow - to - finish 1-site operation in buenos aires province , had 519 sows .
pig death rate from farrowing to slaughter remained at 9.5% before and after the outbreak .
ten days before the outbreak , the farm manager and his wife reported clinical signs of influenza in themselves .
on j... | in june
july 2009 , an outbreak of pandemic ( h1n1 ) 2009 infection occurred on a pig farm in argentina . molecular analysis indicated that the virus was genetically related to the pandemic ( h1n1 ) 2009 influenza virus strain .
the outbreak presumably resulted from direct human - to - pig transmission . |
a distinct population of splenic igmigdcd21cd1 peripheral b lymphocytes known as marginal zone ( mz ) b cells resides close to the marginal sinus 123456 .
other b cells , including some memory cells , also reside in mzs but can be distinguished from mz b cells .
mz b cells are large lymphocytes , have a distinct mo... | although immunoglobulin ( ig)mhiigdlo/cd21hi marginal zone b cells represent a significant proportion of naive peripheral splenic b lymphocytes , few of the genes that regulate their development have been identified .
this subset of peripheral b cells fails to emerge in mice that lack nuclear factor ( nf)-bp50 .
le... |
chronic lymphocytic leukemia ( cll ) is one of the most common hematologic malignancies , affecting approximately 510 people per 100,000.(1 ) population - based data indicate that patients with cll are at increased risk for developing second cancers compared to the general population.(25 ) specific malignancies for whi... | it is unknown whether individuals with monoclonal b - cell lymphocytosis ( mbl ) are at risk for adverse outcomes associated with chronic lymphocytic leukemia ( cll ) , such as the risk of non - hematologic cancer .
we identified all locally - residing individuals diagnosed with high count mbl at mayo clinic between ... |
there are numerous notions relating to mental illness and mental health in manimekalai , the tamil buddhist epic of the post - sangam era of tamil literature .
this period is renowned for the publication of the eight anthologies and 10 lyrics and also the 18 didactical works including thirukkural .
all these works ... | this article refers to materials of psychiatric interest found in the manimekalai written by the 2nd century ce buddhist poet sathanar . from the early description of a wandering psychotic in the streets of pukar , the ancient maritime capital of the cholas it is opined that this description fits that of present - day ... |
type 1 diabetes ( t1d ) remains the predominant form of diabetes in childhood ( 1,2 ) .
an increase in incidence over the past three decades worldwide , with significant geographic variation , has been reported ( 311 ) , with some studies showing a downward shift in the age at diagnosis ( 68,12 ) .
registries have ... | the search for diabetes in youth study prospectively identified youth aged < 20 years with physician - diagnosed diabetes .
annual type 1 diabetes ( t1d ) incidence per 100,000 person - years ( 95% ci ) overall , by age - group , and by sex were calculated for at - risk non - hispanic white ( nhw ) youth from 2002 th... |
blood blister - like aneurysms ( bbas ) have several unique characteristics that differ from those of regular saccular aneurysms . these include 1 ) a typical small hemispheric , broad - based appearance , with a lack of an identifiable neck originating from a non branching site of an artery1,10,15,16,22 ) ; 2 ) instab... | objectiveblood blister - like aneurysms ( bbas ) resemble arterial dissections . the purpose of this study was to investigate the relationship between these two disease entities and highlight commonalities and distinct features.methodsamong 871 consecutive patients with aneurysmal subarachnoid hemorrhage , 11 bbas of i... |
the prevalence rate of chronic degenerative arthritis is very high . among elderly persons
aged 65 years or more ,
females are estimated to have two times higher prevalence rates of
chronic degenerative arthritis than males , and most elderly persons have degenerative
arthritis1 .
the physical characteristic... | [ purpose ] the purpose of this study was to examine the effects of closed kinetic chain
exercises ( ckces ) and open kinetic chain exercises ( okces ) with elastic bands on the
electromyographic activity of patients with degenerative gonarthritis .
[ subjects ] the
study subjects were 30 degenerative gonarthri... |
modified dna strands undergo a reversible light - induced
reaction
involving the intramolecular photodimerization of two appended anthracene
tags . the photodimers exhibit markedly different binding behavior
toward a complementary strand that depends on the number of bases
between the modified positions . by ... | |
the importance of being physically active has been well documented from a public health perspective , with increased activity associated with reduced risk for the development of chronic health conditions like cardiovascular disease [ 14 ] .
researchers have also reported positive mental health outcomes ranging fr... | examining behavioral and psychological factors relating to weight stability over a 1-year period is of public health importance .
we conducted a physical activity ( pa ) intervention trial for women ( n = 247 ; mean age = 47.5 10.7 ; mean bmi = 28.6 5.3 ) in which participants were assigned to one of three groups (... |
according to the who classification , undifferentiated carcinoma of the pancreas ( udc ) is defined as containing large eosinophilic pleomorphic cells and/or ovoid - to - spindle - shaped cells that grow in cohesive formation , and it has a poor prognosis .
undifferentiated carcinoma with osteoclast - like giant cell... | undifferentiated carcinoma of the pancreas ( udc ) is rare and has a dismal prognosis . here , we report a case of 6-year disease - free survival with a mixed type of udc and udc with osteoclast - like giant cells , with a high mitotic index as well as perineural , lymphatic , vessel , and diaphragmatic invasion .
th... |
heavy menstrual bleeding is a significant health problem in premenopausal women and that would be equivalent to menorrhagia ( 1 , 2 ) . the treatment of menorrhagia can either be medical therapy , hysterectomy or destruction of the endometrial .
medical therapy is the first - line therapy , but this is not successful... | aim : heavy menstrual bleeding is one of the common health problems in women . the first - line therapy of heavy menstrual bleeding is the medical therapy , but this is not successful .
currently , global ablation procedures were introduced for treating of heavy menstrual bleeding .
the aim of this study was to the... |
bacteria and their byproducts have key role in the initiation and progression of pulpal and periapical diseases .
root canal morphology is a complex system with ns , anastomoses and lateral or accessory canals which harbor microorganisms .
enterococcus faecalis ( e. faecalis ) which is a gram - positive , facultati... | introduction : the aim of this study was to evaluate the antimicrobial effect of eucalyptus
galbie and myrtus communis l. methanolic extracts , chlorhexidine ( chx ) and sodium hypochlorite ( naocl ) on enterococcus faecalis ( e. faecalis ) as the predominant species isolated from infected root canals . methods and m... |
various predisposing factors include some religious and cultural practices , personal hygiene , smoking , phimosis , inflammatory conditions such as lichen sclerosus or balanoposthitis , ultraviolet radiation , and the presence of human papillomavirus .
squamous - cell carcinoma ( scc ) is the major histopathological... | penile cancer is rare cancer . while inguinal and pelvic nodal metastasis is common , distant metastasis is rare .
we here present the interesting case of a 59-year - old male patient with penile carcinoma , previously treated with penectomy and inguinal lymphadenectomy 10 years earlier .
he presented with bone pai... |
epidemic of diabetes mellitus is growing globally , with 90% of all diabetes patients having type 2 diabetes mellitus ( t2 dm ) . t2
the progressive nature of the disease leads to the development of microvascular complications resulting in increased morbidity and health care costs .
about 50% of patients suffering ... | background : the increasing incidence of type 2 diabetes mellitus globally has collaterally increased the incidence of diabetes - associated complications such as neuropathy .
oxidative stress induced dna damage is one of the mechanisms implicated in the pathogenesis of diabetic complications .
here we aimed to eva... |
myiasis or infestation with fly larvae is common in domestic and wild mammals around the world , and is caused by different species of flies .
advanced age , poor hygiene , bad housing conditions , vascular disease , and diabetes are the predisposing factors for myiasis . in humans
, myiasis is seen more frequently... | we have reported a case of a 40-year - old male diabetic patient , resident of a rural area , who visited the outpatient clinic of the diabetic center in alnoor specialist hospital , makkah , saudi arabia .
he came to seek medical advice for a single wound in the back of the shoulder since 1 month .
after examinati... |
approximately 260,000 cases of pulmonary embolism ( pe ) are clinically diagnosed each year in the united states ; and , in the absence of prophylaxis , the incidence of fatal pe ranges from 0.1% - 0.8% in patients undergoing elective general surgical procedures . since the introduction of laparoscopic cholecystectomy ... | deep venous thrombosis and pulmonary embolism are concerning causes of morbidity and mortality in patients undergoing general surgical procedures .
laparoscopic surgery has gained rapid acceptance in the past several years and is now a commonly performed procedure by most general surgeons .
multiple anecdotal repor... |
many studies indicate that breast cancer health disparities exist among women of different races , ethnicities , socioeconomic statuses , geographic locations and age [ 1 , 2 ] . according to the centers for disease control and prevention ( cdc ) , national program of cancer registries ( npcr )
while the age - adjust... | mobile health units are increasingly utilized to address barriers to mammography screening . despite the existence of mobile mammography outreach throughout the us
, there is a paucity of data describing the populations served by mobile units and the ability of these programs to reach underserved populations , addres... |
hypereosinophilia is an abnormal condition defined by the presence of more than 500 eosinophils per microliter of blood .
hypereosinophilia occurs in allergic reactions , helminthic infestation , collagen vascular disease and malignancies etc .
( 1 , 2 ) . the diagnosis of the idiopathic hypereosinophilic syndrome ... | we report here a case with hypereosinophilia and peripheral artery occlusion . a 32-yr - old korean woman presented to us with lower extremity swelling and pain .
angiography revealed that multiple lower extremity arteries were occlusive .
the biopsy specimen showed perivascular and periadnexal dense eosinophilic i... |
inherited arrhythmia syndromes may cause sudden cardiac arrest ( sca ) in patients with a structurally normal heart .
mutations in the voltage gated sodium channel can produce distinct arrhythmogenic syndromes : brugada syndrome ( brs ) , long qt3 syndrome ( lqt3 ) and progressive cardiac conduction disease .
mutat... | inherited arrhythmia syndromes are a known , albeit rare , cause of sudden cardiac arrest which may present with characteristic electrocardiogram changes in patients with structurally normal heart .
there are a variety of distinct arrhythmogenic syndromes that arise from mutations in voltage gated sodium channels , r... |
thymic cysts account for 1% to 3% of anterior mediastinal masses and can be divided into two types - congenital cysts and acquired cysts . acquired thymic cysts , unlike congenital cysts , are multilocular and arise as a reactive process secondary to inflammation or malignancy .
multilocular thymic cysts ( mtcs ) hav... | multilocular thymic cysts with follicular hyperplasia are uncommon masses that occur in human immunodeficiency virus ( hiv ) positive individuals .
these cysts mostly present in hiv positive children . here
we report a rare case of multilocular thymic cyst in an hiv positive adult female . in this case report ,
t... |
study patients were enrolled from june 11 through 30 , 2009 , a time that corresponds to the end of autumn and the beginning of winter in the southern hemisphere .
patients seeking care at cemic university hospital and other healthcare providers in buenos aires ( federal district ) were enrolled if they met the crite... | to determine clinical and virologic characteristics of pandemic ( h1n1 ) 2009 in buenos aires , argentina , we conducted real - time reverse transcription pcr on samples from patients with influenza - like illness , june 1130 , 2009
. of 513 patients tested , 54% were positive for influenza virus subtype h1n1 .
in... |
boron nitride nanotubes ( bnnts ) , similar to carbon nanotubes ( cnts ) , have attracted wide attention thanks to their potentially unique and important properties in structural and electronic applications.1,2 a bnnt is a structural analog of a cnt , but , despite this similarity , it presents many different chemical ... | boron nitride nanotubes ( bnnts ) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties . during recent years , our group has pioneered the use of bnnts for biomedical applications , first of all assessing their in vitro cytocompatibility on many di... |
in clinical research , both outcomes and predictors are frequently collected repeatedly over time and complex mediated relationships may be present among the variables of interest .
for example , in a study of the relationship between alcohol use and hiv disease progression , heavy alcohol consumption may affect anti... | linear mixed models ( lmms ) are frequently used to analyze longitudinal data .
although these models can be used to evaluate mediation , they do not directly model causal pathways
. structural equation models ( sems ) are an alternative technique that allows explicit modeling of mediation .
the goal of this pape... |
over the past 50 years
or so , there have been many reports of ab
diblock copolymer self - assembly in solvents that are selective for
only one block . in principle
, varying the relative degrees of polymerization ( dp )
( and hence volume fractions ) of each block enables a wide range of
morphologies to be... | a series
of non - ionic poly(glycerol monomethacrylate)poly(2-hydroxypropyl
methacrylate ) ( pgma phpma ) diblock copolymer vesicles has been
prepared by reversible addition fragmentation chain transfer
( raft ) aqueous dispersion polymerization of hpma at 70 c at
low ph using a carboxylic acid - based chai... |
china is the world s largest cigarette consumer and producer ( 1 ) . in 2002 , about 350 million chinese adults reported having smoked at some point and 300 million reported being smokers at the time ( 2 ) .
chronic obstructive pulmonary diseases ( copd ) are a growing health problem and remain a major consumer of he... | backgroundinformation about chronic obstructive pulmonary diseases ( copd)-related health resources allocation in china is very limited .
the aim of the study was to explore the distribution of copd - related health resources allocation among different levels public hospitals ( phs ) in hunan province of central sout... |
the human rad51 protein ( hsrad51aaabbreviations : hsrad51 , human rad51 protein ; ssdna , single - stranded dna ; dsdna , double - stranded dna ; poly(da ) , poly(deoxy-1,n6-ethenoadenylic acid ) ; itc , isothermal titration calorimetry . ) is crucial for dna repair processes that are based on homologous recombination... | we have previously shown that a 28-amino acid peptide derived from the brc4 motif of brca2 tumor suppressor inhibits selectively human rad51 recombinase ( hsrad51 ) . with the aim of designing better inhibitors for cancer treatment
, we combined an in silico docking approach with in vitro biochemical testing to const... |
dermatopathic lymphadenitis ( dln ) is a well - described histopathological entity characterized by the expansion of the subcortical zone by dendritic histocytoid cells due to barrier disruption of dependent skin .
dln is often seen in patients with skin diseases exfoliative or eczematoid inflammatory erythrodermas ,... | dermatopathic lymphadenopathy usually presents as enlarged superficial lymph nodes , most often involving the axillary or inguinal regions .
most patients have a chronic dermatopathy that precedes the development of dermatopathic lymphadenopathy .
this condition can be confused with lymphoma in adults .
there are... |
alpha-1 antitrypsin deficiency ( aat ) is a hereditary recessive autosomal disease caused by mutations in the aat gene .
this disease is characterized by abnormally low aat concentrations in plasma , which , in its homozygote form , carries a high risk of the development of early pulmonary emphysema and , occasionall... | the spanish registry of alpha-1 antitrypsin deficiency was founded in 1993 and became a member of the international registry ( air ) in 1999 .
we describe the updating process following its incorporation into air and compare the data collected in the first period ( 19931999 ) and the second period ( 19992005 ) , duri... |
the work of teachers has a fundamental social value because education can ensure economic
growth , and technical and scientific development in any society . in brazil
, there are over
2.6 million teachers working in basic and higher education , and they are responsible for
instructing millions of brazilian stud... | this is a cross - sectional study conducted with 258 teachers from nine state
schools in two municipalities of so paulo state with the purpose of assessing their work
ability .
a questionnaire with socio - demographic and health / work conditions data and the
work ability index ( wai ) was performed .
most te... |
during the past decade , community - associated methicillin - resistant staphylococcus aureus ( ca - mrsa ) has emerged worldwide .
although there have been some evidences of intercontinental spread of major ca - mrsa clones , most ca - mrsa clones showed the continent - specific distribution ( 1 ) .
especially , p... | panton - valentine leukocidin ( pvl)-positive usa300 clone has been the most successful community - associated methicillin - resistant staphylococcus aureus ( ca - mrsa ) clone spreading in north america . in contrast , pvl - negative st72-ca - mrsa has been predominant in korea , and there has been no report of infect... |
cardiovascular diseases remain the most frequent cause of global death worldwide , and the most common is coronary artery disease , with a mortality rate of 12.8% in 2011 . acute coronary syndromes significantly contribute to the burden of cardiovascular disease .
reduction of cardiovascular diseases is therefore a k... | backgroundcannabis is known to be associated with neuropsychiatric problems , but less is known about complications affecting other specified body systems .
we report and analyze 35 recent remarkable cardiovascular complications following cannabis use.methods and resultsin france , serious cases of abuse and dependen... |
the article by cuthbertson and colleagues deals with an important topic these days in perioperative anesthesia and intensive care .
numerous clinical studies published in recent years seem to fit together like pieces of a puzzle , with the same overall message : hemodynamic optimization by fluid loading , particularl... | there is increasing evidence that hemodynamic optimization by fluid loading , particularly when performed in the early phase of surgery , is beneficial in high - risk surgery patients : it leads to a reduction in postoperative complications and even to improved long - term outcome .
however , it is also true that goa... |
crick
base pairing , while the structural , regulatory , and catalytic functions
of rna are achieved by the formation of well - defined 3d structures
resulting from a combination of normal watson crick pairs and
a wide variety of non - canonical base pairs as well as other tertiary
interactions .
base
in... | structural studies of modified nucleobases
in rna duplexes are
critical for developing a full understanding of the stability and
specificity of rna base pairing .
2-thio - uridine ( s2u ) is
a modified nucleobase found in certain trnas .
thermodynamic studies
have evaluated the effects of s2u on base pair... |
stds are transmitted from someone to another through sexual activities and close touch ( vaginal , rectal and oral ) . among the most common stds are chlamydia , gonorrhea , trachoma , herpes , syphilis and hiv .
american diseases prevention and control center ( 2010 ) reported prevalence of chlamydia , gonorrhea , s... | background : vulnerable women are prone to sexually transmitted diseases ( std ) due to their special conditions and poor knowledge about these diseases in the society . therefore , the present study aimed to determine the vulnerable women s self - care needs in knowledge , attitude and practice concerning std.methods:... |
brain fingerprinting is a variant of the guilty knowledge or concealed information test ( gkt / cit ; lykken 1959 , 1960 ) . the cit aims to determine the presence or absence of crime - related information in a suspect s memory .
it has been used with a variety of dependent measures , most notably with recordings of ... | in a recent issue of cognitive neurodynamics farwell ( cogn neurodyn 6:115154 , 2012 ) published a comprehensive tutorial review of the use of event related brain potentials ( erp ) in the detection of concealed information .
farwell s review covered much of his own work employing his brain fingerprinting technolog... |
regeneration of periodontal tissue that has been lost as a result of disease is the ultimate objective of periodontal therapy in advanced periodontal breakdown .
periodontal regeneration can be achieved by a variety of non - surgical and surgical therapies .
periodontal surgical debridement and resective osseous su... | objective : the purpose of the study was to evaluate the clinical effectiveness of periosteum as a barrier membrane for the treatment of intrabony defects.materials and methods : the study was conducted in patients having bilateral intrabony defects .
a total of 20 intrabony defects in 10 patients were treated , out ... |
study areas and ethics statement - t. cruzi isolates
from humans , triatomine bugs and mammalian reservoirs from 19 departments ( amazonas ,
arauca , boyac , bolvar , caquet , caldas , casanare , cesar , cundinamarca , guaina ,
guajira , huila , magdalena , meta , norte de santander , putumayo , santander , tolim... | trypanosoma cruzi is the aetiological agent of chagas disease , which
affects approximately eight million people in the americas .
this parasite exhibits
genetic variability , with at least six discrete typing units broadly distributed in
the american continent .
t. cruzi i ( tci ) shows remarkable genetic
... |
in 2008 , there were 796 million illiterate adults , which represents approximately 17% of the world 's adult population.1 the illiteracy rate remains high among the elderly in south korea , especially in rural areas .
in yonchon , a korean rural agricultural area , 26.4% of the elderly are reported to be illiterate ... | background and purposethe literacy - independent cognitive assessment ( lica ) has been developed for a diagnosis of dementia and is a useful neuropsychological test battery for illiterate populations as well as literate populations .
the objective of this study was to develop the short form of the lica ( s - lica ) ... |
many studies on treadmill walking using a body weight support ( bws ) device for patients
with dysbasia have recently been reported .
werning1 and dietz2
reported its usefulness in improving the walking ability of spinal cord injury patients in
1992 and 1994 , respectively , and walking speed - increasing and w... | [ purpose ] to investigate the therapeutic usefulness of treadmill walking using a body
weight support device ( bws ) , changes in circulatory dynamics and muscle activities with
various levels of support were investigated .
[ subjects and methods ] the subjects were
divided into 3 groups : 20% bws , 40% bws , ... |
the term polyp of the colon refers to a protuberance into the lumen from the normally flat colonic mucosa .
polyps are usually asymptomatic but may ulcerate and bleed , cause abdominal pain , and , when very large , produce intestinal obstruction .
they are small nodules or polypoid lesions composed of normal cellu... | aimthe aim of this study was to report the anatomical location and histologic type of colorectal polyps in a large series of iranian patients that attended for colonoscopy.backgroundpolyps that develop through the adenoma - carcinoma pathway are considered neoplastic and may eventually progress to invasive carcinomas .... |
participants were recruited in january 2008 by 48 general practitioners from a cooperation of 14 primary care practices in eindhoven and five surrounding villages .
a dutch translation of the finnish diabetes risk score ( findrisc ) ( 13 ) was sent to general practitioner patients aged 40 and 70 years ( n = 16,032 ) ... | objectiveto study the overall effect of the active prevention in high - risk individuals of diabetes type 2 in and around eindhoven ( aphrodite ) lifestyle intervention on type 2 diabetes risk reduction in dutch primary care after 0.5 and 1.5 years and to evaluate the variability between general practices.research desi... |
type 2 diabetes mellitus ( t2 dm ) is one of the fastest growing health problems in the world , reaching epidemic proportion ; globally it is estimated that 382 million people suffer from diabetes , that is , a prevalence of 8.3% .
t2 dm is the fourth leading cause of death in developed countries , with a twofold exc... | type 2 diabetes mellitus ( t2 dm ) is associated with increased risk of cardiovascular disease and nephropathy now the leading cause of end - stage renal disease and dialysis in europe and the united states .
inflammation and oxidative stress play a pivotal role in the development of diabetic complications .
silym... |
heroin - induced spongiform leukoencephalopathy ( hsle ) usually affects young people and is characterized pathologically by vacuolar degeneration as a result of primary damage to myelin . the spongiform vacuolar degeneration is closely associated with the severity of demyelination in the cerebral white matter .
most... | a 22-year - old man with a 2-year history of heroin vapor inhalation developed spongiform leukoencephalopathy and underwent clinical and home - based rehabilitative treatments .
activities of daily living were measured using the functional independence measure at discharge and at 6 , 12 , and 24 months after discharg... |
for the past few decades , there has been a growing interest in the modification and application of chitosan in medical and health fields .
chitosan has been the material of choice for the preparation of nanoparticles in various applications due to its biodegradable and nontoxic properties .
chitosan is soluble in ... | the need of natural antimicrobials is paramount to avoid harmful synthetic chemicals .
the study aimed to determine the antifungal activity of natural compound chitosan and its nanoparticles forms against candida albicans , fusarium solani and aspergillus niger .
chitosan nanoparticles were prepared from low ( lmw ... |
development of patient safety has a major role in preventable disabilities and mortalities in hospitals .
patient safety improvements are being achieved as a result of medical care provided for patients in countries , which have direct impacts on lives saved and preventing patients disabilities .
evidence is gradua... | background : patient safety is one of the major issues concerning the medical community and the world health organization ( who ) in most countries .
this study aimed to evaluate the patient safety status in an eye hospital in tehran , using the who model for patient safety friendly hospital initiatives ( psfhi ) in ... |
the epidemiologic evidence of the prevalence and consequences of pediatric obesity is well documented . currently , there is considerable emphasis on establishing effective prevention and treatment protocols for pediatric obesity [ 2 , 3 ] . in 2007 ,
an expert committee put forth recommendations for the assessment ,... | this paper describes fitkids360 , a stage 2 pediatric weight management program .
fitkids360 is a physician - referred , multicomponent , low - cost healthy lifestyle program for overweight and obese youth 516 years of age and their families .
fitkids360 provides an evidence - based approach to the treatment of ped... |
central venous catheter ( cvc)-related bloodstream infection is associated with significant mortality and morbidity in critically ill patients , much of the focus , however , has remained on the bacterial pathogens .
catheter - associated mycobacteremia is a rare entity , even in oncology patients undergoing chemothe... | mycobacterium fortuitum is a rapidly growing mycobacterium ubiquitous in nature , known to form biofilms .
this property increases its propensity to colonize the in situ central line and makes it a prospective threat for nosocomial infection .
we report a case of 48-year - old female with carcinoma cecum who report... |
catalytic techniques
for producing graphene and carbon nanotubes
( cnts ) , particularly those based on chemical vapor deposition ( cvd ) ,
are widely seen as most promising for achieving the requisite level
of control over material structure and quality that is demanded by
applications .
key to growth cont... | the
dynamics of the graphene catalyst interaction during
chemical vapor deposition are investigated using in situ , time- and
depth - resolved x - ray photoelectron spectroscopy , and complementary
grand canonical monte carlo simulations coupled to a tight - binding
model .
we thereby reveal the interdepen... |
social intelligence monitoring in persons with orbitofrontal cortex injury was the subject of a previous article in this journal .
the authors reported there impairments in conversations with strangers on intimate topics , that is , unconscious , inappriopriate self - disclosure while answering questions .
such sel... | summarybackgroundthe aim of present article is to compare patients with damage to the orbitofrontal cortex and prison inmates in terms of social intelligence and social intelligence monitoring . in addition
, personal principles and emotional regulation of behavior will be assessed in both groups.material/methods20 p... |
prognosis in patients with breast cancer depends mainly on the extent of lymph node involvement , size of the tumor , and the histological grade of the tumor . among these factors ,
axillary lymph node status is regarded as the single best marker of prognosis [ 1 , 2 ] . for axillary nodal involvement , treatment in ... | introduction .
controversy continues over the appropriate timing of sentinel lymph node ( sln ) biopsy in locally advanced breast cancer ( labc ) patients receiving neoadjuvant chemotherapy .
we evaluated the feasibility and accuracy of sln biopsy in labc patients with cytology - proven axillary nodal metastasis wh... |
dermatological terms may be more than a mouthful ; they can be difficult to remember and highly esoteric .
an electronic and manual search of standard dermatology texts was done to compile these terms .
this article is meant to serve as an interesting aid to dermatology , upon which residents can build their knowle... | the world of dermatology is pieced together by clinical conditions unique in their colors , morphology , and configuration .
dermatological signs and terms are influenced by etymology , language , and history .
eponyms also make dermatology a fascinating but linguistically challenging subject .
this article revie... |
neck circumference ( nc ) was recently associated with various cardiovascular risk factors such as insulin resistance and biochemical components of metabolic syndrome such as fasting glucose , fasting triglycerides , and blood pressure , independent of body mass index ( bmi ) and waist circumference [ - ] .
however ,... | backgroundneck circumference ( nc ) has been previously related to cardiometabolic risk factors . in this study
we examined the association between nc and early stage atherosclerosis in chinese adults.methodsthe study samples were from a community - based health examination survey in central china . in total 2,318 me... |
for all subjects , demographic , anthropometric , biochemical , and anatomical data included in the current study were reported previously ( 6,7 ) .
briefly , human sural nerve biopsies were obtained during a double - blind , placebo - controlled , 52-week trial of alc .
the trial included both type 1 and 2 diabeti... | objectivepatients with diabetic neuropathy ( dn ) demonstrate variable degrees of nerve regeneration and degeneration . our aim was to identify risk factors associated with sural nerve degeneration in patients with dn.research design and methodsdemographic ,
anthropometric , biochemical , and anatomical data of subje... |
one of the challenges that we encountered in extending the linneaus collaboration beyond the confines of countries where primary care was already well established was in developing a mechanism to get engagement from physicians and policymakers to an agenda that explicitly addressed issues related to patient safety .
... | abstract
background : accreditation of primary care organizations within greece is still in its infancy .
our task in greece was to attempt to introduce a patient safety initiative in a local area , focusing on developing minimum standards for accreditation , assess whether a pragmatic approach would engage physici... |
sepsis was defined as gbs bacteremia in the presence of consistent clinical signs and symptoms .
capsular typing was performed by a multiplex pcr as described ( 9 ) , and the hypervirulent st-17 clone was detected by real - time pcr , as reported ( 6 ) .
susceptibility testing , antibiograms , and mics were perform... | clinical features and molecular characterization of 109 group b streptococci causing neonatal invasive infections were determined over an 18-month period in france .
sixty - four percent of the strains were from late - onset infections , and 75% were capsular type iii .
the hypervirulent clone st-17 was recovered i... |
malignant neoplasms arising primarily from the heart and large vessels are rare , and those arising from the pulmonary artery are even rarer . patients with pulmonary artery tumor are at increased risk of life - threatening events when they become symptomatic .
major artery thromboembolism and acute right heart failu... | undifferentiated malignant neoplasms , which occur primarily in the pulmonary artery , are extremely rare and associated with poor outcomes as there is no effective therapy .
a 67-year - old woman visited our hospital with complaints of dry cough and dyspnea on exertion .
a contrast - enhanced chest computed tomogr... |
all data were obtained from the university healthsystem consortium ( uhc ) ( chicago , il ) clinical data base / resource manager ( cdb ) , a large administrative database to which uhc principal members submit comprehensive administrative data files .
uhc 's principal members include approximately 120 us academic med... | backgroundthe recent intense attention to hospital readmissions and their implications for quality , safety , and reimbursement necessitates understanding specific subsets of readmitted patients .
frequently admitted patients , defined as patients who are admitted 5 or more times within 1 year , may have some disting... |
diabetes mellitus represents a major risk factor for the development of coronary artery disease [ 1 , 2 ] and an important predictor of outcome in patients undergoing percutaneous coronary intervention ( pci ) [ 3 , 4 ] .
recent studies have suggested a potential and independent prognostic role of preprocedural blood... | poor glycemic control is associated with unfavorable outcome in patients undergoing percutaneous coronary intervention ( pci ) , irrespective of diabetes mellitus .
however a complete assessment of glycemic status may not be fully described by glycated hemoglobin or fasting blood glucose levels , whereas daily glycem... |
systemic lupus erythematosus ( sle ) is a chronic autoimmune disease of unknown origin that affects several organ systems ; diverse immunological abnormalities that are associated with this disease have been recognized both in human and in animal models with the most consistent being : ( 1 ) loss of b cell tolerance , ... | dysregulation of cytokines is among the main abnormalities in systemic lupus erythematosus ( sle ) .
however , although , estrogens , which are known to be involved in lupus disease ,
influence cytokine production , the underlying molecular mechanisms remain poorly defined .
recent evidence demonstrates the prese... |
dehumanization , by which they mean the thing that occurs when a subject , s , perceives people who belong to some cultural outgroup , g , as having a lesser degree of humanity than herself and others she identifies with .
their inquiry is partly motivated by the conjecture which they credit to the psychologist gord... | murrow and murrow offer a novel account of dehumanization , by synthesizing data which suggest that where subject s has a dehumanized view of group g , s 's neural mechanisms of empathy show a dampened response to the suffering of members of g , and s 's judgments about the humanity of members of g are largely non - co... |
the negative change of muscle mass from maturity to senescence and the corresponding loss of functional capacity are of high clinical significance [ 1 , 2 ] .
the most physiologic means to fight this decline of muscle mass and function is a physically active lifestyle or even better , physical exercise .
indeed , a... | the most effective physiologic mean to prevent sarcopenia and related muscle malfunction is a physically active lifestyle , or even better , physical exercise .
however , due to time constraints , lack of motivation , or physical limitations , a large number of elderly subjects are either unwilling or unable to perfo... |
some 4 to 5 billion years ago , the earth formed , and almost as soon as it cooled about 500 million years later , life emerged . for another 2 billion years , the most toxic antagonist to life , oxygen , accumulated in the atmosphere until it reached the levels we face today .
bacteria evolved the trick of harnessin... | fifteen years of apoptosis research have led to the widely accepted idea that the major form of programmed cell death in mammals proceeds via the mitochondria , and that mitochondrial control of apoptosis is regulated by a specialized family of proteins known as the bcl-2 family . here
we will consider some very rece... |
a term appropriate for gestational age , male baby admitted to our neonatal intensive care unit with vesicular rash with erythematous base on the face on day 5 of life . on the next day ,
mother had developed vesicular skin eruptions with severe pruritus suggestive of chicken pox 2 days prior to the delivery , which ... | the presentation of varicella in the newborn depends upon the time of onset of infection in the mother .
varicella in neonates presents as congenital or neonatal varicella .
our case , admitted to us on day 5 of life had a severe infection as the mother had developed rashes only 2 days prior to delivery . |
most of the current global clinical practice recommendations , including those of the american diabetes association , the european association for the study of diabetes , and the korean diabetes association , propose that metformin , if there are no contraindications , should be initiated with concurrent lifestyle m... | we evaluated the prevalence of vitamin b12 deficiency and associated factors in type 2 diabetes patients using metformin .
a total of 799 type 2 diabetes patients using metformin was enrolled .
vitamin b12 and folate levels were quantified by chemiluminescent enzyme immunoassay .
vitamin b12 deficiency was define... |
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