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infantile systemic hyalinosis and juvenile hyaline fibromatosis are very rare hereditary disorders which usually occur in arabs and exceedingly rare in indians .
hyaline fibromatosis syndrome ( hfs , online mendelian inheritance in man 228600 ) is a rare autosomal recessive condition characterized by deposition of am... | hyaline fibromatosis syndrome ( hfs ) is rare autosomal recessive disease characterized by the deposition of amorphous hyaline material in skin and visceral organs .
it represents a disease spectrum with infantile systemic hyalinosis ( ish ) being the severe form and juvenile hyaline fibromatosis ( jhf ) being the mi... |
a choroidal hemangioma is an uncommon benign vascular tumor of the choroid that can be either circumscribed or diffuse . in our experience ,
diffuse choroidal hemangiomas in asian patients often require multiple photodynamic therapy ( pdt ) treatment sessions .
five sessions of pdt treatment were required over a pe... | backgrounda choroidal hemangioma is an uncommon benign vascular tumor of the choroid that can be either circumscribed or diffuse . in our experience ,
diffuse choroidal hemangiomas in asian patients often require multiple photodynamic therapy ( pdt ) treatment sessions.methodswe here provide a case report of a 7-year... |
parasitic infections which emerge in wildlife may have a significant effect on individuals and populations ( mller , 2005 ) .
this is especially a critical issue in the conservation of threatened species ( thompson et al . , 2010 ) .
therefore , understanding the role of infectious and parasitic agents in wildlife... | the full course of new parasite introductions in wild animals is difficult to accurately trace .
we documented and analysed the invasive blood - sucking nematode ashworthius sidemi ( trichostrongylidae ) introduction and spread in european bison ( bison bonasus ) from the initial phase of its progression . in the pol... |
the high prevalence of child obesity remains a global public health concern . in response to the increasing number of overweight and obese children , government and non - government agencies in many countries
have invested in programs that address modifiable factors ( for example , diet , physical activity and screen... | background / objective : to report 30-year ( 19852015 ) prevalence trends in overweight , obesity and abdominal obesity among children by school level and socioeconomic status ( ses).subjects / methods : five cross - sectional , population child surveys ( age 418 years ; n=27 808 ) conducted in 19851997200420102015 in... |
in patients with alzheimer 's disease ( ad ) , plaques
comprised of aggregated -amyloid peptides ( a ) accumulate in specific areas of the brain as a
consequence of the proteolytic processing of the single - pass
transmembrane amyloid precursor protein ( app ) .
these a deposits trigger prolonged inflammation... | amyloid peptide ( a ) aggregates , derived from initial -site proteolytic processing of the amyloid precursor
protein ( app ) , accumulate in the brains of alzheimer 's disease
patients .
the plasmin - generating cascade appears to serve a
protective role in the central nervous system since
plasmin - mediated... |
nocturia is defined as waking at night to void urine , and nocturia has been reported in 58 - 90% of people over 50 years of age , with the prevalence of nocturia increasing with age .
this condition can significantly impair a patient 's perception of their well being and often warrants treatment , especially when th... | introductionwe examined the efficacy of combination therapy with 1-blocker tamsulosin and hypnotic zolpidem in patients who had suffered from sleep disturbance associated with nocturia.material and methodsa total of 35 patients diagnosed with nocturia with lower urinary tract symptoms ( luts ) suggestive of benign pros... |
human papillomavirus ( hpv ) is the main cause of cervical cancer , the third most common cancer in women .
there is , however , growing evidence linking genital hpv infection to other anogenital cancers ( anus , vulva , vagina , and penis ) and head and neck cancers in both men and women [ 311 ] .
hpv is carried b... | cervical cancer and other human papillomavirus- ( hpv- ) related cancers are preventable , but preventive measures implemented in developing countries and especially in low - income rural regions have not been effective .
cervical cancer burden derived from sexually transmitted hpv infections is the heaviest in devel... |
as a vital neurotransmitter ,
acetylcholine ( ach ) activates ion
channels and g protein coupled receptors ( gpcrs ) through its interactions
with nicotinic and muscarinic ( machr ) acetylcholine receptors , respectively . among the five machrs , subtypes 1 , 4 , and 5 ( m1 , m4 , and m5 ) are most strongly assoc... | a functional
high throughput screen identified a novel chemotype
for the positive allosteric modulation ( pam ) of the muscarinic acetylcholine
receptor ( machr ) subtype 5 ( m5 ) .
application of rapid analog ,
iterative parallel synthesis efficiently optimized m5 potency
to arrive at the most potent m5 pa... |
cell - matrix adhesion involves several processes including integrin binding , cell spreading , and flattening against the substrate .
cultured cells , that spread out on ligand coated surfaces , rearrange their cytoskeleton and begin to move .
these focal complexes grow into mature focal contacts , also called foc... | cytotoxic necrotizing factors ( cnfs ) encompass a class of autotransporter toxins produced by uropathogenic e. coli ( cnf1 ) or y. pseudotuberculosis ( cnfy ) .
cnf toxins deamidate and thereby constitutively activate rhoa , rac1 , and cdc42 . in this study , the effects of cnf1 on cell - matrix adhesion are analyse... |
gingival recession is one of the most common aesthetic and functional concerns associated with periodontal tissues .
it is defined as the displacement of soft tissue margin apical to cemento enamel junction with exposure of root surface .
gingival recession is well documented in populations having a good standard... | objective : the objective of this study was to clinically evaluate and compare the efficacy of platelet concentrate graft ( pcg ) with that of subepithelial connective tissue graft ( sctg ) using a coronally advanced flap technique in the treatment of gingival recession.materials and methods : twelve patients with a to... |
therefore , the current dentistry , which must be based on scientific evidences , has been searching for alternatives and new techniques on a regular and evolutionary basis .
periodontics is a branch of dentistry that searches for solutions in the construction of the facial esthetics , in which the harmony between li... | the containment of the elevator muscle of the upper lip and wing of nose was used for the treatment of patients with gummy smile . this technique had corrected esthetic alterations of smile , reducing the upper lip elevation , which results in a smaller gingival display . an upper lip lengthening as well as a reduction... |
chest radiographs ( cxrs ) are routinely utilized to access changes in status of newborns and infants in the neonatal intensive care setting and often lead to changes in management .
differences in image interpretation have been attributed to multiple factors including differences in the interpreters knowledge base ,... | objective : variability in image interpretation has been attributed to differences in the interpreters knowledge base , experience level , and access to the clinical scenario .
picture archiving and communication system ( pacs ) has allowed the user to manipulate the images while developing their impression of the ra... |
the sensation of pain accompanies the majority of human diseases , alerting the body to the presence of harmful stimuli .
pain may be modulated by a series of behavioral events , since , in addition to transmission of the stimulus that is causing the pain , the process also involves different emotional , environmenta... | the objective of the present study was to evaluate the antinociceptive effects of phytol using chemical and thermal models of nociception in mice and to assess its antioxidant effects in vitro .
phytol was administered intraperitoneally ( i.p . ) to mice at doses of 25 , 50 , 100 , and 200 mg / kg . in the acetic ac... |
the calcium ion ( ca ) is a ubiquitous intracellular messenger during and immediately after an ischemic period , and it influences the cascade of events that lead to subsequent neuronal injury.1 under ischemic conditions , release of glutamate from the neurons and glia activates the n - methyl - d - aspartate ( nmda ) ... | background and purposean elevated intracellular calcium level is known to be a major initiator and activator of ischemic cell death pathway ; however , in recent studies , elevated serum calcium levels have been associated with better clinical outcomes and smaller cerebral infarct volumes .
the pathophysiological rol... |
calciphylaxis is a rare disease entity first described by bryant and white in 1898 to characterize a syndrome exemplified by vascular calcifications with cutaneous necrosis .
attempts to shed light on its pathophysiology was undertaken by selye et al . in 1962 using a rat model to induce calcinosis through a series o... | calciphylaxis , or calcific uremic arteriolopathy , commonly affects people with end - stage renal disease and carries with it a high rate of morbidity and mortality . here
, we present the unusual case of a 56-year - old woman , with extensive medical problems , who developed calciphylaxis in the presence of primary... |
we studied the effects of weight loss and non - weight - bearing exercise ( swimming ) on blood and organ lead and essential metal concentrations in rats with prior lead exposure .
nine - week - old female sprague - dawley rats ( n = 37 ) received lead acetate in their drinking water for 2 weeks , followed by a 4-day... | |
the lifetime risk of urolithiasis is estimated to be between 5% and 12% in europe and the united states .
acute renal colic is commonly observed in emergency rooms and is usually described as an acute flank pain radiating to the groin .
it is often caused by ureteral stones . because up to 98% of ureteral calculi o... | purposeto evaluate the efficacy and safety of the ureteroscopic management of ureteral stones immediately after a first colic attack.materials and methodswe retrospectively analyzed the data of 226 patients with obstructive ureteral stones who underwent ureteroscopy with stone retrieval .
the 67 patients in group a u... |
the incidence of urinary tract stone disease is increasing . according to the national health and nutrition examination survey , as of 2012
, 10.6% of men and 7.1% of women in the united states are affected by renal stone disease , compared to just 6.3% of men and 4.1% of women that were affected in 1994 .
further ... | the epidemiology of kidney stones is evolving not only is the prevalence increasing , but also the gender gap has narrowed . what drives these changes ?
diet , obesity or environmental factors ?
this article will review the possible explanations for a shift in the epidemiology , with the hope of gaining a better u... |
shallow portions of major continental strike - slip faults are exposed to brittle deformation conditions . at crustal levels
34 km , kakirites ( heitzmann , 1985 ) dominate such strike - slip faults , the porosity is therefore high , and vertical fluid flow is dominant resulting in fluid rock interaction and format... | based on structural and fabric analyses at variable scales we investigate the evaporitic gypsum - dominated comeglians - paularo shear zone in the southern alps ( friuli ) .
it represents the lateral western termination of the brittle fella - sava fault . missing dehydration products of gypsum and the lack of anneali... |
purpureocillium lilacinum ( thom ) formerly paeciliomyces lilacinus ( thom ) is a non - melanized , ubiquitous , environmental , filamentous mold .
infection caused by this species , now referred to as purpureocilliosis , is sporadic and usually limited to immunosuppressed humans or animals .
p. lilacinum has b... | purpureocillium lilacinum and beauveria bassiana were isolated from lung sampled at necropsy of a 12 year - old female loggerhead sea turtle ( caretta caretta ) that had displayed abnormal buoyancy .
histopathologic evaluation revealed pleuritis and pneumonia with non - melanized , septate hyphae and fruiting structu... |
amp v. myriad treats genetic material as a product of nature : the genome is a natural resource that scientists discover but do not invent .
the genome clearly fits the definition of a natural resource : something that is found in nature and is necessary or useful to humans . by accepting this fact , the supreme c... | the supreme court 's recent decision in association for molecular pathology v. myriad genetics portrays the human genome as a product of nature .
this frames medical genetics as an extractive industry that mines a natural resource to produce valuable goods and services .
natural resource law offers insights into pr... |
to date , more than 50 million cancer survivors have been treated with radiotherapy worldwide.1 ) it is well documented that radiotherapy can induce a type of vascular disease , termed vasculopathy.2)3 ) in addition , it has become increasingly evident that cranial radiation therapy increases the risk of stroke for can... | we report herein a case of a radiation - induced aneurysm . a 69-year - old woman presented with subarachnoid hemorrhage .
eight years previously , she had undergone cranial radiation therapy ( total dose of 59.4 gy ) as adjuvant therapy after surgical resection for a chondrosarcoma that was destroying her sphenoid s... |
during open - heart surgery , protamine is used after weaning the patient from cardiopulmonary bypass ( cpb ) in order to reverse the anticoagulation effects of heparin .
however , protamine shows a wide spectrum of adverse effects , ranging from minimal cardiovascular deterioration to cardiovascular collapse , which... | fatal anaphylactic reactions to protamine sulfate during cardiac surgery are very rare .
we report a case of catastrophic bronchial spasm due to an anaphylactic reaction to protamine .
the patient was managed successfully using a bronchodilator , steroid treatment , and extracorporeal membrane oxygenation . |
a portion of the arterial pressure wave travelling towards the extremities is reflected back from peripheral impedance points . in healthy individuals , the reflected wave returns to the aorta during diastole . with age and in the presence of vascular disease ,
arterial compliance decreases , and the arteries become ... | background . augmentation index ( aix ) is traditionally obtained from pressure waveforms via arterial applanation tonometry .
we sought to evaluate the association between
aix obtained from peripheral arterial tonometry ( pat ) with cardiovascular risk factors ( crf ) and coronary artery disease ( cad ) .
method... |
it allows the clinicians to better time gestation - specific antenatal screening tests , reduces erroneous labelling of pregnancies as very preterm , preterm , and small - for - gestational - age , and decreases the risk of inappropriate induction of labour [ 15 ] . in the first trimester , there is a very little biolo... | accurate determination of gestational age underpins good obstetric care . we assessed the performance of six existing ultrasound reference charts to determine gestational age in 1268 singleton ivf pregnancies , where
true
gestational age could be precisely calculated from date of fertilisation .
all charts genera... |
some researchers have argued that sleep disturbances experienced with the increase of age can be linked to the other changes , including the significant increase of medical and mental health problems and lifestyle alterations .
it is estimated that 30 - 45% of the world s population complaint from sleep disorders[49 ... | context : sleep is an effective factor in the process recovery from diseases .
many variables affect the sleep quality of hospitalized older patients.aim:this study was conducted to evaluate the quality of sleep and its related risk factors in hospitalized older patients in kashan s hospitals , iran 2009 .
settings... |
have many perceived benefits , including increased accessibility and social connection , efficiency in the workplace , convenience , and improved safety .
however , in recent years , there has been increasing public interest in the negative consequences of mobile phone use . in one saudi arabian study , 44.4% of part... | this study aimed to develop and assess the psychometric properties of an english language measure of problematic mobile phone use .
participants were recruited from a university campus , health science center , and other public locations .
the sample included 244 individuals ( 68.4% female ) aged 1875 .
results s... |
spinocerebellar ataxia type 3 ( sca3 ) is one of nine polyglutamine expansion diseases and the most common dominantly inherited ataxia in the world .
while certain symptoms in sca3 may respond to symptomatic therapy , there is still no effective treatment for this relentlessly progressive and fatal neurodegenerative ... | the most common dominantly inherited ataxia , spinocerebellar ataxia type 3 ( sca3 ) , is an incurable neurodegenerative disorder caused by a cag repeat expansion in the atxn3 gene that encodes an abnormally long polyglutamine tract in the disease protein , atxn3 .
mice lacking atxn3 are phenotypically normal ; hence... |
gtpase of the immunity - associated protein family ( gimaps ) , also termed immune - associated nucleotide - binding proteins ( ians ) , are a relatively recently described , uncharacterized protein family of putative small gtpases conserved among vertebrates and higher plants [ 14 ] .
the original publications descr... | ( gimaps ) gtpase of the immunity associated protein family are a novel protein family of putative small gtpases .
gimaps are mainly expressed in the cells of the immune system and have been associated with immunological functions , such as thymocyte development , apoptosis of peripheral lymphocytes and t helper cell... |
a 56-year - old male patient visited emergency room of our hospital with myalgia , chill and fever of 38.0c .
he revealed intrahepatic ductal dilatation on the abdomen ct and positive antibody test for clonorchis sinensis .
we conducted him brain mri which showed bitemporal signal change with enhancement and edema ... | various neurologic manifestations of herpes simplex virus ( hsv ) encephalitis have been reported on the literatures .
chorea , ballism , choreoathetosis and myoclonus were reported as movement disorders which might be related with brain lesion by hsv encephalitis , but negative myoclonus ( nm ) has never been report... |
the present study utilized an experimental design via pre - test and post - test in three groups .
the participants were selected from the child psychiatry clinic of ibn - e - sina psychiatric hospital in mashhad using convenience sampling .
this sample size was calculated using g power software version 3.1 with al... | objectivethe aim of the current study was to examine the effectiveness of barkley s parent training program , working memory training and the combination of these two interventions for children with attention deficit hyperactivity disorder ( adhd).methodsin this study , 36 participants with adhd ( aged 6 to 12 years ) ... |
in the 1950s , pulse - chase experiments using radioactive precursors showed that ~95% of the rna made in mammalian nuclei is degraded within minutes . at the time
, no credible reason could be proposed for this astonishing turnover , and only later did we discover it results from the destruction of non - coding rnas... | astrophysicists use the term dark matter to describe the majority of the matter and/or energy in the universe that is hidden from view , and biologists now apply it to the new families of rna they are uncovering . we review evidence for an analogous hidden world containing peptides .
the critical experiments involv... |
the 2,5-oligoadenylate ( 2 - 5a ) synthetase ( oas)/rnase l system is a uniquely regulated innate immune pathway that restricts viral infections ( reviewed in reference 1 ) .
the interferon ( ifn ) inducible oas family of proteins include pathogen recognition receptors for viral double - stranded rna ( dsrna ) that s... | abstractthe interferon ( ifn)-inducible antiviral state is mediated in part by the 2,5-oligoadenylate ( 2 - 5a ) synthetase ( oas)/rnase l system .
2 - 5a , produced from atp by oas proteins in response to viral double - stranded rna , binds to and activates rnase l. rnase l restricts viral infections by degrading vi... |
markov modeling is frequently used to estimate the costs and consequences of two or more interventions for a specific condition.1 in these models , the consequence of each treatment is often estimated in terms of quality - adjusted life - years ( qalys ) . in order to calculate the qalys accrued , the life years are we... | backgroundforeign utilities of the eq-5d-3l ( 3-level version of the euroqol-5 dimension of health questionnaire ) are not readily transferrable to economic evaluations conducted from a national perspective .
it has been advised to avoid transferring mean utilities from one country to another without adjusting them ;... |
it is a complex clinical syndrome that involves memory impairment , behavioral
disorders , and personality changes1 .
the
main features of dementia are reduced cognitive ability , neurological and psychiatric
symptoms , and functional disability2 .
alzheimer s disease ( ad ) has a similar clinical presentatio... | [ purpose ] this study evaluated the effects of combined fine motor skill and cognitive
therapies on cognition , depression , and activities of daily living in elderly patients
with alzheimer s disease ( ad ) . [ subjects and methods ] twenty - six participants comprised 2
groups .
the experimental group ( n=13... |
laparoscopic adrenalectomy , first reported by gagner et al , is the standard of care for management of adrenal diseases .
recent technological advances in the form of newer energy sources , such as ultrasonic shears and the vessel - sealing system , have made performance of such advanced laparoscopic surgical proced... | background : newer , energy - based devices like the ultrasonic coagulator ( harmonic scalpel , ethicon endo - surgery , inc . , cincinnati , oh ) and the ligasure vessel - sealing system ( valleylab , boulder , co ) are increasingly being used in advanced laparoscopic procedures .
use of these devices has resulted i... |
pollution has wide - ranging consequences , for health as well as in other sectors . following a health impact assessment of particulate matter emissions , this study aims to quantify the labour market consequences of particulate emissions as part of a cost - benefit analysis of mitigation efforts .
the costs include... | the objective of this study was to analyse the productivity cost savings associated with mitigation of particulate emissions , as an input to a cost - benefit analysis . reduced emissions of particulate matter ( pm2.5 ) may reduce the incidence of diseases related to air pollution and potentially increase productivity ... |
in the past decades , polymer solar cells have attracted more and more scientific attention due to their advantages , such as low cost , light weight , easy fabrication , and the possibility to fabricate flexible devices , compared with inorganic solar cells [ 1 - 5 ] .
however , the limited dissociation of photoexci... | the photovoltaic properties of solar cell based on the blends of poly[2-methoxy-5-(2-ethylhexoxy-1,4-phenylenevinylene ) ( meh - ppv ) , fullerene ( c60 ) , and zncdte - alloyed nanocrystals were investigated . comparing the spectral response of photocurrent of the meh - ppv : c60(+zncdte ) nanocomposite device with th... |
ten children with a clinical and/or radiologic evidence of white matter involvement were identified from a cohort of 46 pediatric patients , 18 years of age and younger , with a range of nmdar - abs associated neurologic syndromes . between 2009 and 2013 ,
patients were referred , based on clinician decision , from ... | objective : to report the clinical and radiologic findings of children with nmda receptor ( nmdar ) antibodies and white matter disorders.method:ten children with significant white matter involvement , with or without anti - nmdar encephalitis , were identified from 46 consecutive nmdar antibody positive pediatric pat... |
the present paper focuses particularly on one of the simplest and most potent lysophospholipids , lysophosphatidic acid ( lpa ) , and summarizes recent knowledge on its biological impact on human and ruminant reproduction .
lysophosphatidic acid is a simple phospholipid that exerts many physiological and pathological... | lysophosphatidic acid ( lpa ) through activating its g protein - coupled receptors ( lpar 16 ) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female .
studies in various species of animals and also in humans have identified important roles... |
in recent years , there has been considerable interest in the clinical significance of subthreshold depression ( ie , the presence of clinically relevant depressive symptoms that do not meet the full criteria of a major depressive episode [ mde ] ) in adolescence.1 subthreshold depressive symptoms among adolescents are... | purposedespite its clinical importance , adolescent subthreshold depression remains a largely neglected topic .
the aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode ( mde ) in late adolescents with subthreshold depression ove... |
dna methylation ( 5-methylcytosine ,
5mc ) plays critical biological
functions in mammals and plants as a vital epigenetic marker .
the
ten - eleven translocation dioxygenases ( tet1 , 2 , and 3 ) have been found
to oxidize 5mc to 5-hydroxymethylcytosine ( 5hmc ) and then to 5-formylcytosine
( 5fc ) and 5-c... | |
a 40-year - old man sought evaluation of a 4-year - history of perianal and perineal pain , including the testes and penis . in this patient , there was no notable history of trauma or disease . on mri and ct scans , which included the abdomen and pelvis , there were normal findings . at the time of admission , the pat... | chronic perineal pain is an often encountered problem , which produces a great degree of functional impairment and frustration to the patient and a challenge to the treating physician .
the reason for this problem is that the region contains diverse anatomic structures with mixed somatic , visceral and autonomic inne... |
peristalsis has been studied in vivo and in vitro , but other factors , such as intra - abdominal pressure , respiration , and the pressure of adjacent structures among others , have received little attention .
peristalsis is considered to be myogenic in origin , with neuro - hormonal factors playing only a modulator... | introductionuntil now , peristalsis has been the only known method of urine transport .
the main objective of this paper was to study urinary tract function especially the upper urinary tract , the ureter from a new mechanical point of view .
the physical ( physical dual valves ) and biological basis ( biological... |
colonoscopy is considered as one of the most commonly performed medical procedures and deemed to be safe .
however , the complication rates are increasing as its use is growing due in part to the successful promotion of colorectal cancer screening and prevention guidelines .
post - colonoscopy , the incidence of co... | colonoscopy is performed for both diagnostic and therapeutic indications .
although rare , associated complications can be quite serious .
the frequency of these complications depends mainly on the skills of the physicians doing the procedure , and the diagnostic or therapeutic indications .
major complications i... |
taking into consideration all these aspects , in what follows we present a model of an individualized therapy , in a case of bipolar affective disorder .
it is the case of a 44-year - old male patient , included in our psychiatric records in 1997 , with the diagnosis
bipolar affective disorder type i ( manic - depr... | morbidity , mortality and economic consequences of bipolar affective disorder are very important to be evaluated because many of the costs entailed by this psychiatric disorder come from indirect costs due to inadequate diagnosis and treatment and from the characteristics of the affective symptoms itself .
psychother... |
transcription is the synthesis of an rna molecule complementary to the dna template by the action of several enzymes .
transcription , whether prokaryotic or eukaryotic , has three main sequential events such as initiation , elongation , and termination [ 1 , 2 ] .
initiation is the most important step and involves... | transcription is a process by which the genetic information stored in dna is converted into mrna by enzymes known as rna polymerase .
bacteria use only one rna polymerase to transcribe all of its genes while eukaryotes contain three rna polymerases to transcribe the variety of eukaryotic genes . rna polymerase also... |
sigmoid diverticulosis has a prevalence of up to 60% in 70-year - old individuals , of whom 1025% may progress to diverticulitis and a further 1025% of these may develop complications such as abscess formation , perforation or fistulas . the mortality rate has been demonstrated to be 0.55% .
the most common symptoms ... | even though the incidence of toxic epidermal necrolysis ( ten ) is low , it is also associated with a high mortality rate .
the condition predominantly affects the skin , but may also affect the gastrointestinal tract , dramatically increasing mortality .
we present a case of perforated sigmoid diverticulitis in th... |
briefly , gst - tagged rat -arrestin1 in the pgex4 t vector was transformed into bl21(de3 ) cells , large scale expression cultures were grown in terrific broth , and induced with 1 mm iptg for 16 hr at 16 c .
cell pellets were lysed in 20 mm hepes ph 7.4 , 150 mm nacl , 1 mm pmsf and 2 mm dtt using a micro fluidizer... | the functions of g - protein coupled receptors ( gpcrs ) are primarily mediated and modulated by three families of proteins : the heterotrimeric g proteins , the g - protein coupled receptor kinases ( grks ) , and the arrestins1 .
g proteins mediate activation of second messenger - generating enzymes and other effect... |
however , variations in the facial nerve have been reported and they increase the risk of facial nerve injury during parotid surgery . herein , we report a unique case of a parotid tumor in conjunction with a facial nerve anomaly .
key pointswe report a new variation in the facial nerve pattern , and an unusual relat... | abstractthe branching pattern of the facial nerve varies among individuals .
these variations increase the risk of facial nerve injury during parotid surgery .
we report a new variation of the facial nerve and an unusual relationship with the retromandibular vein during parotid surgery.clinicians should recognize t... |
diabetes mellitus is one of the most common metabolic disorders in the world ( 1 , 2 ) .
the number of patients with this disease is predicted to reach over 366 million people in 2030 ( 4 ) . in recent years , increasing prevalence of diabetes mellitus as a chronic disease has prompted investigators to find ways to c... | backgroundthis study was conducted to investigate the effects of brewer s yeast supplementation on serum lipoproteins and blood pressure in patients with type 2 diabetes mellitus.methods:in a randomized double blind clinical trial , 90 adults with type 2 diabetes mellitus were recruited , and divided randomly into 2 gr... |
biliary cast syndrome is defined as the presence of casts within the intra- and/or extrahepatic bile ducts , causing obstruction and cholangitis , eventually complicated by multiple strictures , ductal dilation , and/or liver microabscesses.1,2 this is an uncommon condition , but is more frequently described in liver t... | development of biliary casts is very unusual , especially in patients who have not undergone liver transplantation .
variable causes of biliary cast formation in nonliver transplantation patients have been suggested .
however , stasis of bile flow and/or gallbladder hypocontractility is known to eventually result i... |
1,3-dichloro-2-propanol
( dcp ) is a member of the broad chemical
class halohydrins .
dcp is a semivolatile liquid used in high volume
as an intermediate in the production of epichlorohydrin ( ech ) , 1,3-dichloropropene ,
and 1,2,3-trichloropropane .
workers may be exposed
to 1,3-dcp via inhalation , der... | the observed toxicity and carcinogenicity
of 1,3-dichloro-2-propanol
( dcp ) in rodents is thought to be due to the formation of reactive
metabolites , epichlorohydrin ( ech ) and dichloroacetone ( dca ) .
however ,
there is no direct evidence for the formation of these metabolites
from exposure to dcp in r... |
organophosphorus ester pesticides ( ops ) are mainly used as agricultural and domestic insecticides , leading to increasing numbers of cases of toxic effects on humans and livestock .
ops poisoning can result in neurotoxicity , myocardial damage , microvascular dysfunction , cytotoxicity , respiratory failure , and f... | we investigated the effect of paraoxon on vascular contractility using organ baths in thoracic aortic rings of rabbits and examined the effect of paraoxon on calcium homeostasis using a whole - cell patch - clamp technique in isolated aortic smooth muscle cells of rabbits .
the findings show that administration of pa... |
termine et al
. first demonstrated that sequential dissociative extraction and fractionation procedures with protease inhibitors could provide a convenient approach for the study of mineral compartment constituents .
the primary extraction regimen used 4 m guanidine hcl to remove most of the protein from the nonmin... | |
the kindlins represent a class of focal adhesion proteins implicated in integrin activation . they comprise three evolutionarily conserved members , kindlin-1 ( fermt,1 , c20orf42 , urp1 ; chromosome 20p12.3 ) , kindlin-2 ( fermt2 , mig2 , plekhc1 , unc112 , ; chromosome 14q22.1 ) and kindlin-3 ( fermt3 , unc-112 relat... | kindlin proteins represent a newly discovered family of evolutionarily conserved ferm domain - containing proteins .
this family includes three highly conserved proteins : kindlin-1 , kindlin-2 and kindlin-3 .
all three kindlin proteins are associated with focal adhesions and are involved in integrin activation .
... |
dengue ( den ) fever is the most diagnosed traveler - related illness , with 390400 million cases / year worldwide1,2 and an incidence rate of ~2.5%5% of > 2 billion people at risk.3 however , only an estimated 3%8% of symptomatic travelers are den virus ( denv)-positive via serological tests.4 infection with one denv ... | the objective of this study was to improve risk assessments of travel on dengue ( den ) virus ( denv ) distribution .
we investigated the exposure risk of us citizens traveling to den - endemic pan american countries .
the number of den cases reported in 51 pan american countries from 2001 to 2012 was compared to t... |
osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue , leading to increased bone fragility and a consequent increase in fracture risk .
consequently , noninvasive techniques for measuring bone mineral density ( bmd ) play an important role in the clinical diagnosis of ost... | objective . to compare the osteoporosis detection rates in postmenopausal women when measuring bone mineral density ( bmd ) with quantitative computed tomography ( qct ) in the spine versus dual x - ray absorptiometry ( dxa ) in the spine and hip and to investigate the reasons for the discrepancy between the two techni... |
infectious and inflammatory processes , however , can induce new vessel growth causing corneal neovascularization , which leads to scarring , edema , and blindness .
corneal neovascularization affects an estimated 4.1% of all patients presenting to general ophthalmology offices in the us
a meta - analysis has shown... | we assessed the antiangiogenic effects of subconjunctival injection of fc - endostatin ( fce ) using a human vascular endothelial growth factor - induced rabbit corneal neovascularization model .
angiogenesis was induced in rabbit corneas through intrastromal implantations of vegf polymer implanted 2 mm from the lim... |
recently , the use of ni - cr base metal alloys in fixed prosthesis tends to increase because of the continued inflation of gold price .
base metal alloy has various advantages such as higher yield and tensile strength and better resistance to creep , compared with noble alloys.1 - 3 however , base metal alloys also ... | purposethe present study was intended to evaluate the effect of soldering techniques with infrared ray and gas torch under different gap distances ( 0.3 mm and 0.5 mm ) on the tensile strength and surface porosity formation in ni - cr base metal alloy.materials and methodsthirty five dumbbell shaped ni - cr alloy speci... |
the richest uranium ore bodies ever discovered ( cigar lake and mcarthur river ) are presently under development in northeastern saskatchewan .
this subarctic region is also home to several operating uranium mines and aboriginal communities , partly dependent upon caribou for subsistence . because of concerns over mi... | |
primary cardiac tumors are rare , and hemangiomas are believed to represent 1 - 10% of benign forms .
single casereports are described in literature depicting a heterogeneous pathology with significant clinical differences . due to the rarity and the possibility of a silent clinical course
we hereby report a case o... | a 74-year - old man underwent echocardiographic exam for hypertension screening . a fixed plurilobulated mass originating from the right ventricular lateral wall and occupying half of the cavity
was incidentally diagnosed . on cardiac magnetic resonance ( cmr )
it appeared homogeneous , intermediate - to - high sig... |
thromboxane and adp , which are among the mediators of platelet activation and aggregation , play
a key role in initiating and propagating coronary thrombosis and are raised
during myocardial infarction .
simultaneous inhibition of both of these pathways
with the combination of clopidogrel and aspirin produces ... | we investigated the effects of clopidogrel on reperfusion and inflammatory process in stemi .
a total of 175 stemi patients with similar clinical characteristics were included to this study .
one was the standard pharmacological reperfusion therapy group ( group 1 , n : 90 ) , who received 300 mg aspirin , 70 u / k... |
on approval from ethical committee of adhiparasakthi dental college and hospital , the study was started .
photographs of five different subjects with matched teeth were made using the digital single - lens reflex camera under high resolution . using adobe photoshop , version 7 ( adobe systems inc .
, san jose , ca... | aim : the aim of this study was to find the difference in perceptibility and acceptability of changes done to various color coordinates of matched teeth , between trainee dental surgeons , and lay person.materials and methods : a photograph with a set of matched central incisor teeth was selected . in one of the centra... |
poly(vinylidene fluoride ) ( pvdf ) is a partially crystalline linear hydrofluorocarbon polymer exhibiting extraordinary electrical properties , ranging from those of a typical dielectric polymer to those of a versatile ferroelectric material , as a consequence of its crystalline structure and the abundance of polymorp... | wide - angle x - ray scattering in conjunction with pole figure technique was used to study the texture of poly(vinylidene fluoride ) ( pvdf ) and phase crystals in nanolayered polysulfone / poly(vinylidene fluoride ) films ( psf / pvdf ) produced by layer - multiplying coextrusion . in all as - extruded psf / pvdf f... |
in 1963 , rowell et al . described a distinctive subset of patients with lupus erythematosus ( le ) consisting of erythema multiforme - like skin lesions , anti - la ( ss - b)/anti - ro ( ss - a ) antibodies , positive serum rheumatoid factor and a speckled pattern of antinuclear antibodies .
though its progression t... | rowell 's syndrome is now identified as a subtype of subacute lupus erythematosus ( le ) with erythema multiforme - like skin lesions , positive serum rheumatoid factor , anti - ro la positivity and speckled pattern of antinuclear antibodies .
here we describe a case of rowell 's syndrome in an 18-year - old female w... |
hepatitis a virus ( hav ) infects 212 million people each year , including 55 million symptomatic cases and 35,245 deaths ( 1 ) . the virus ( hav ) is a member of the hepatovirus genus of picornaviridae family .
hav is a non - enveloped , linear , single - stranded rna virus ( 2 , 3 ) .
the lack of a lipid envelop ... | backgroundhemophilic patients require long - life intravenous infusion of factor concentrates to treat bleedings .
this could increase the risk of transmission of blood - borne infections like hepatitis c.objectivesthe current study was aimed at investigating the immunity status against hepatitis a in hemophilic pati... |
porokeratosis is a genetic disease transmitted as an autosomal dominant trait featuring abnormal epidermal keratinization , which is histologically characterized by the presence of cornoid lamella .
since then many variants of porokeratosis have been described , each with differing morphology , distribution , and cli... | porokeratosis represents a heterogeneous group of disorders characterized clinically by a distinctive ridge - like border and histologically by cornoid lamellae .
gardner 's syndrome , a variant of familial adenomatous polyposis ( fap ) , is an autosomal dominant disease characterized by colorectal polyps , osteomas ... |
medieval stained glass windows are part of our cultural heritage , but due to their permanent exposure to environmental conditions they have been damaged over centuries . to protect and conserve this valuable material ,
stained glass is made up of several components : network formers , stabilizers , modifiers , and c... | we investigated the decayed historical church window glasses of two catalonian churches , both under mediterranean climate .
glass surfaces were studied by scanning electron microscopy ( sem ) , energy dispersive spectrometry ( eds ) , and x - ray diffraction ( xrd ) .
their chemical composition was determined by w... |
valproic acid ( vpa ) has a clinical use as an anticonvulsant and mood - stabilizing drug , primarily in the treatment of epilepsy , bipolar disorder , and , less commonly , major depression .
hyperammonemia ( ha ) has been generally associated with liver failure or rare genetic mutations in enzymes participating in ... | numerous cases of severe and life - threatening hyperammonemia ( ha ) related to the treatment of epileptic seizures with valproic acid ( vpa ) have been previously reported in the medical literature .
the aim of this prospective , multicenter study was to verify the putative association between t1405 polymorphism an... |
central effect of carbohydrate ( cho ) on endurance performance ( 4 , 6 , 7 , 12 , 13 , 16 ) .
this idea was first postulated when it was discovered that cho ingestion , during activity that is not limited by cho availability or oxidation rate , such as high intensity ( e.g. > 70% vo2max ) relatively short duration (... | there is a substantial body of recent evidence showing ergogenic effects of carbohydrate ( cho ) mouth rinsing on endurance performance .
however , there is a lack of research on the dose - effect and the aim of this study was to investigate the effect of two different concentrations ( 6% and 12% weight / volume , w ... |
increasingly , cardiac biomarkers have provided important information in predicting short - term and long - term risk profiles in patients with acute coronary syndromes ( acs ) , particularly when they are used in combination . among the numerous biomarkers , high - sensitivity c - reactive protein ( hscrp )
has rece... | among the numerous emerging biomarkers , high - sensitivity c - reactive protein ( hscrp ) and growth - differentiation factor-15 ( gdf-15 ) have received widespread interest , with their potential role as predictors of cardiovascular risk .
the concentrations of inflammatory biomarkers , however , are influenced , a... |
a 39-year - old woman ( height : 158 cm , body weight : 45 kg ) had taken nifedipine per oral from the department of the internal medicine for six months . for last one month
the dose of nifedipine was increased due to uncontrolled spasmodic pain in her left toes while her face flushing and headache worsened and she ... | a 39-year - old female was suffering from cold - induced raynaud 's attacks in both hands and feet , with symptoms being most severe in her left foot .
the patient did not respond to medical treatments and was referred to our department of pain medicine .
we performed sequential bipolar radiofrequency lumbar sympat... |
latino immigrant women , particularly mexican women , are at increased risk for developing many preventable health conditions .
this is due in part to limited access to healthcare and benefits , legal status , and limited income . while mexican women have traditionally migrated as a result of their families , their i... | immigrant women of mexican birth face unique health challenges in the united states .
they are at increased risk for developing many preventable health conditions due in part to limited access to healthcare and benefits , legal status , and inadequate income .
increased vulnerability of women has established a grow... |
there are more than 9 million new cases of tuberculosis every year worldwide , and incidence is declining at a rate of less than 1% per year .
nearly 2 million people die from tuberculosis every year , and the costs and social consequences of this disease are vast .
this worldwide burden of tuberculosis has stimula... | summaryreliable and relevant research can help to improve tuberculosis control worldwide . in recent years , various organisations have assessed research needs and proposed priorities for tuberculosis . we summarise existing priority statements and assess the rigour of the methods used to generate them .
we found 33 ... |
ulcerative colitis ( uc ) and crohn 's disease ( cd ) , the major forms of inflammatory bowel diseases ( ibds ) in humans , are chronic inflammatory disorders of the gastrointestinal tract . in uc ,
inflammation is restricted to the mucosa and extends proximally from the rectum to involve all or part of the colon .
... | patients with inflammatory bowel disease ( ibd ) face an increased lifetime risk of developing colorectal cancer ( crc ) .
independent factors associated with increased risk include long disease duration , extensive colonic involvement , young age at onset of ibd , severity of inflammation , primary sclerosing cholan... |
a 42-year - old woman diagnosed with stage iv nsclc ( adenocarcinoma ) was admitted to our hospital in august 2013 and given an ap regimen ( pemetrexed 500 mg / m on day 1 , cisplatin 75 mg / m on days 1 to 3 , repeated every 3 weeks ) as initial chemotherapy on august 2nd , 2013 .
several days later , her egfr genet... | toxic epidermal necrolysis ( ten ) is a rare acute life - threatening mucocutaneous disorder that is mostly drug - related ( 80%-95% ) .
it is clinically characterized as a widespread sloughing of the skin and mucosa .
ap regimen ( pemetrexed plus cisplatin ) has been the preferred first - line chemotherapy for met... |
the incidence of gastric cancer varies widely depending on the geographic region analyzed ; it has been shown to be as high as 8082 per 100,000 inhabitants in some cities in japan ; has an intermediate incidence in costa rica , so paulo , brazil , and cali , colombia ( 50 100,000 inhabitants ) ; and has a low incidenc... | backgroundgastric cancer is an aggressive disease with nonspecific early symptoms .
its incidence and prognosis in young patients has shown considerable variability.purpose of the studyour objective was to retrospectively study patients from our institution aged < 30 years with gastric carcinoma .
the study was und... |
spinal manipulative therapy was defined by world health organization as includes all procedures where the hands or mechanical devices are used to mobilize , adjust , manipulate , apply traction , massage , stimulate , or otherwise influence the spine and paraspinal tissues with the aim of influencing the patient 's he... | abstractcervical spine manipulation ( csm ) is a commonly spinal manipulative therapies for the relief of cervical spine - related conditions worldwide , but its use remains controversial .
csm may carry the potential for serious neurovascular complications , primarily due to vertebral artery dissection ( vad ) and s... |
guajadials c - f ( 14 ) , four sesquiterpenoid - based meroterpenoids with unprecedented skeletons were isolated from the leaves of psidium guajava .
their structures and relative configurations were established by extensive spectroscopic analysis . a possible biosynthetic pathway for 14 was also proposed .
supp... | abstractguajadials c - f ( 14 ) , four sesquiterpenoid - based meroterpenoids with unprecedented skeletons were isolated from the leaves of psidium guajava .
their structures and relative configurations were established by extensive spectroscopic analysis .
a possible biosynthetic pathway for 14 was also proposed.g... |
ashy dermatosis is a hypermelanotic disorder of the idiopathic variety characterized by bluish - grey macules in healthy individuals .
it is a controversial entity and is sometimes considered as a variant of lichen planus .
etiology of ashy dermatosis is mostly unknown and it usually affects the face , arms , neck ... | we present here the case of a young indian male with slowly progressive , diffuse darkening of the face , arms , neck , and trunk .
the patient was not taking any medication and there was no history of any previous skin disease and the mucous membrane was not involved .
these findings are consistent with a diagnosi... |
birt - hogg - dub syndrome ( bhds ) is an inherited autosominal dominant genodermatosis that predisposes individuals to the development of fibrofolliculomas ( ff ) , trichodiscomas ( td ) , and acrochordons of the face , neck , and upper trunk ( 1 ) .
there is also an increased risk for lung cysts , spontaneous pneum... | birt - hogg - dub syndrome ( bhds ) is an autosomal dominant genodermatosis characterized by cutaneous hair follicle tumors ( fibrofolliculoma or trichodiscoma ) , pulmonary cysts , and increased risk of renal neoplasia .
the genetic alteration for bhds has been mapped to chromosome 17p12q11 , and the gene in this re... |
research conducted since 1980 in relation to inheritance patterns and dna testing of major genes for prolificacy has shown that major genes have the potential to significantly increase the reproductive performance of sheep flocks throughout the world .
mutations that increase ovulation rate have been discovered in th... | |
a 52-year - old woman was referred to our department with a growing calcified mass in the left shoulder .
she had been previously diagnosed with interstitial lung disease and progressive systemic sclerosis eight and five years prior , respectively .
four years before admission , chest computed tomography first reve... | extensive tumoral calcinosis affecting a large joint is uncommon in patients with systemic sclerosis .
we report the case of a 52-year - old female patient referred for a growing calcified mass in the shoulder .
she was diagnosed with interstitial lung disease and progressive systemic sclerosis .
although the pai... |
pelvic radiation may be associated with an elevated risk of secondary bladder malignancies that may be seen as early as five years after exposure .
intravesical bcg therapy is a standard treatment for high - risk nonmuscle - invasive bladder cancer ( nmibc ) ( clinical stages ta , tis , and t1 ) .
we have previousl... | purpose .
intravesical bacillus calmette - guerin ( bcg ) immunotherapy is indicated for high - grade nonmuscle - invasive bladder cancer ( nmibc ) .
the efficacy of bcg in patients with a history of previous pelvic radiotherapy ( rt ) may be diminished .
we evaluated the outcomes of radical cystectomy for bcg - ... |
since 1983 , as the leading cause of death , cancer has become a major public health concern in korea .
annually , over 190,000 patients are newly diagnosed with cancer in korea , and one out of four deaths is due to cancer .
although the cancer registration system in korea is very efficient and can provide nationw... | purposeto estimate the current cancer burden in korea , cancer incidence and mortality rates were projected for the year 2012.materials and methodsthe cancer incidence data from 1999 to 2009 were obtained from the korea national cancer incidence database , and the cancer mortality data from 1993 to 2010 were obtained f... |
although it can affect any one , it is more common in women , especially pregnant women and those who are taking contraceptives or hormone replacement therapy .
melasma is thought to be the stimulation of melanocytes to produce more melanin pigments when there is sun exposure .
melasma symptoms are dark , irregular... | background : melasma is a common acquired disorder characterized by symmetric , hyperpigmented patches with an irregular outline , occurring most commonly on the face . it is most prevalent among young to middle - aged women .
although iron overload affects skin pigmentation , effect of iron deficiency on skin is not... |
in a medicolegal case where aman has injured his knee at work , a physician ( an orthopaedic surgeon ) provides the following testimony : given the mechanical symptoms of catching and lock , his failure to progress with rest , a home exercise program and anti - inflammatories it is medically indicated to proceed with ... | backgroundthe aim of this study was to investigate whether physicians who felt strongly for or against a treatment , in this case a moderately life prolonging non - curative cancer treatment , differed in their estimation of medical indication for this treatment as compared to physicians who had no such sentiment .
a... |
fast acquisition is an important issue in magnetic resonance imaging ( mri ) for avoiding physiological effects and reducing scanning time on patients .
unfortunately , accelerating acquisition by reducing k - space samples leads to noise amplification , blurred object edges , and aliasing artifacts in mr reconstruct... | nonconvex optimization has shown that it needs substantially fewer measurements than l
1 minimization for exact recovery under fixed transform / overcomplete dictionary . in this work ,
two efficient numerical algorithms which are unified by the method named weighted two - level bregman method with dictionary updat... |
the traditional technique for indirect esthetic restorations consists of taking an impression of the tooth immediately after preparation , followed by the luting of a provisional restoration . after the indirect restoration fabrication
, the provisional material is removed and an adhesive system is applied to the too... | objectives : the objective of this study is to evaluate , in vitro , the thickness of immediate dentin sealing ( ids ) materials on full crown preparations and its effect on the fracture load of a reinforced all - ceramic crown.materials and methods : sixty premolars received full crown preparation and were divided int... |
bioluminescence tomography ( blt ) is a rapidly growing field of research in optical molecular imaging , which allows for the visualization of normal and abnormal cellular processes in living subjects at the molecular or genetic level [ 14 ] .
with blt , we seek to recover the spatial distribution of bioluminescent l... | a finite element mesh aggregating approach is presented to reconstruct images of multiple internal bioluminescence sources . rather than assuming independence between mesh nodes , the proposed reconstruction strategy exploits spatial structure of nodes and aggregation feature of density distribution on the finite eleme... |
the advent of structural genomics initiatives has led to an increase in the number of protein 3d structures and hence there is a growing need for novel analysis tools ( 13 ) .
maintenance of the various analysis programs on changing computer platforms is becoming a problem for many users .
the protein tools page at... | the www servers at are dedicated to the analysis of protein 3d structures submitted by the users as the protein data bank ( pdb ) files .
cx computes an atomic protrusion index that makes it possible to highlight the protruding atoms within a protein 3d structure .
dpx calculates a depth index for the buried atom... |
for the last 30 years free flap reconstructive surgery has become routine , while basic principles of microsurgery have changed very little .
the search for new techniques and modifications of already existing ones is gaining increasing attention .
progress in flap designing and harvesting have improved the functio... | backgroundthe search for new surgical flap techniques and modifications of already existing ones is gaining increasing popularity .
progress in flap designing and harvesting have improved the functional and aesthetic results , especially in head and neck reconstruction.material/methodsten pigs were used in this study... |
in bisexual organisms with chromosomal sex determination , sex - linked genes occur in
different dosages in the two sexes , and this dosage difference in genes not directly
related to sex determination is compensated by a variety mechanisms , such as
deactivation of... | little is known about dosage compensation in autosomal genes .
transcription - level
compensation of deletions and other loss - of - function mutations may be a
mechanism of dominance of wild - type alleles , a ubiquitous phenomenon whose
nature has be... |
dendritic cells ( dcs ) have been found to be the pivotal antigen presenting cells ( apcs ) in regulation of immune response .
activation through the t cell receptor in the absence of costimulation is proposed to render responder t cells anergic or tolerant .
the costimulatory signal is delivered through interactio... | implementation of dendritic cell- ( dc- ) based therapies in organ transplantation can reduce dependency on nonspecific immunosuppression . despite extensive research
, mechanisms of equipped dcs inducing transplant tolerance remain incomplete . here
, we applied rna interference technique to inhibit cd80 and cd86 ... |
protein dynamics on the micro- to millisecond time scale
is increasingly
found to be critical for biological function , as demonstrated by numerous
nmr relaxation dispersion studies .
methyl groups are excellent probes
of protein interactions and dynamics because of their favorable nmr
relaxation properties... | |
diffusion - weighted imaging ( dwi ) is increasingly regarded as a promising modality in breast lesion detection and characterization [ 14 ] .
adc values were demonstrated to be reduced in breast cancers compared to normal tissue and benign lesions due to the increased cellularity .
dwi is now regarded as a very ... | backgroundthe aim of this study was to investigate whether the anisotropy parameters are helpful in the detection and discrimination of breast cancers , and to determine its value in predicting the risk of cancers.material/methodsthere were 56 patients with 56 lesions ( 34 malignant , 22 benign ) included in the study ... |
methicillin - resistant staphylococcus aureus ( mrsa ) infections are associated with significant mortality and health care costs.1 in nearly all hospitals , mrsa has become one of the gram - positive bacterial species associated with serious hospital - acquired infections.29 the population of patients most vulnerable ... | backgroundmethicillin - resistant staphylococcus aureus ( mrsa ) infections are associated with significant mortality and health care costs . to improve treatment outcomes for mrsa , a better understanding of the pharmacokinetic / pharmacodynamic parameters of vancomycin
is required to develop optimal dosing strategi... |
according to the eau guidelines nephron - sparing surgery ( nss ) has a similar oncological outcome to that of radical surgery . however , nss is not suitable in some patients with localized renal cell carcinoma ( rcc ) because : 1 ) of locally advanced tumor growth , 2 ) partial resection is not technically feasible... | radical open nephrectomy is considered the standard treatment for kidney tumors or masses greater than 10 cm .
we present a rare case of acute pancreatitis that occurred after right radical transperitoneal nephrectomy , which was treated by nonsurgical conservative interventions.the incidence of acute pancreatitis af... |
focal segmental glomerulosclerosis is the second most common cause of idiopathic nephrotic syndrome ( ns ) in adults .
kidney transplantation in patients with fsgs has a recurrence rate of 2040% after first transplant and up to 5080% in subsequent transplants .
plasmapheresis has been used as mainstay of therapy fo... | recurrence of focal segmental glomerulosclerosis ( fsgs ) is common after kidney transplantation .
plasmapheresis ( pp ) is considered to be the most effective treatment ; however , results are variable and relapse is common after stopping plasmapheresis . here , we report an unusual case of recurrent fsgs , who achi... |
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