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thalassemia syndromes and iron deficiency anemia ( ida ) are the two most common etiologies of microcytic hypochromic anemia in children and adults .
it has long been considered that iron deficiency does not exist in thalassemia syndromes , including thalassemia major as well as trait .
however , studies have shown... | background . coexistence of iron deficiency anemia ( ida ) and beta thalassemia trait ( btt ) has been the topic of few studies .
however , no study from our country was found evaluating the effect of iron therapy in patients with concomitant ida and btt .
methods . over a period of two years , 30 patients with con... |
idiopathic normal pressure hydrocephalus ( inph ) is a syndrome that is characterized by gait disturbance , mental deterioration and urinary incontinence , in association with normal cerebrospinal fluid ( csf ) pressure .
the characteristic mri findings in inph include enlarged ventricle systems ( vs ) and sylvian fi... | objectivesto measure the cerebrospinal fluid ( csf ) space volume in idiopathic normal pressure hydrocephalus ( inph ) , we developed a software that allows us to automatically measure the regional csf space and compared the volumes of the ventricle systems ( vs ) , sylvian fissures ( sf ) and sulci at high convexity a... |
obesity is a risk factor able to trigger several inflammatory alterations favorable for the chronic low - grade inflammation , by imbalance between pro- and anti - inflammatory cytokine productions .
furthermore , obesity is positively associated with installation and development of diseases as type 2 diabetes , card... | obesity is a risk factor able to trigger several inflammatory alterations and the imbalance between pro- and anti - inflammatory cytokine productions .
physical exercise is an important strategy for reduction of inflammatory established process .
the aim of this study was to evaluate the effect of 16 weeks of three... |
113 705 ) predispose carriers to early - onset of breast and ovarian cancer with a risk of 6571% for breast cancer and 3959% for ovarian cancer by age 70 years .
variants in brca1 are scattered throughout the gene , and to date ( until 1 october 2013 ) , approximately 14 900 variants ( listed online at the breast c... | mutational screening of the breast cancer susceptibility gene brca1 leads to the identification of numerous pathogenic variants such as frameshift and nonsense variants , as well as large genomic rearrangements .
the screening moreover identifies a large number of variants , for example , missense , silent , and intr... |
according to the world health organization reports ( who ) , 22% of the world 's population aged over 15 years are smokers and approximately six million people die from tobacco use or exposure to tobacco smoke .
studies in iran show that about 26% of the iranian men and 3.6% of the women participating in the study ar... | background : tobacco consumption is the second major cause of death and the fourth most common risk factor for diseases , worldwide .
epidemiologic studies have traced the use of alcohol , tobacco , and illicit substances among medical students and physicians.objectives:the current study aimed to investigate the prev... |
halogenated ethers bearing several f or cl atoms have been known for many years as narcotic gases . in these derivatives ,
the presence of one or several halogen atoms tends to make the ch bonds more acidic , which gives rise to specific interactions with surrounding enzymes and neuroreceptors [ 16 ] .
enflurane ( ... | increase of the atmospheric concentration of halogenated organic compounds is partially responsible for a change of the global climate . in this work
we have investigated the interaction between halogenated ether and water , which is one of the most important constituent of the atmosphere .
the structures of the co... |
an overview of the triatominae species of suriname was generated based on the specimens
and collection data available at the collections of the bureau of public health in
suriname ( bog ) and the national zoological collection of suriname ( nzcs ) , anton de kom
university , on the information provided by the nat... | nine species of triatominae , representing three tribes and five genera , are currently
known in suriname .
an annotated list of the species based on the collections of the
bureau of public health ( suriname ) , the national zoological collection suriname and
the national history museum leiden ( the netherlands... |
primary hyperparathyroidism ( phpt ) is associated with an increased risk of premature death in malignant disorders.13 the prevalence of phpt is highest in postmenopausal women , ie , 3%4% , and the origin is most often a single parathyroid adenoma.4,5 certain malignant tumors are over - represented , and breast cancer... | background : primary hyperparathyroidism ( phpt ) is associated with an increased risk of developing breast cancer , but little is known about the underlying factors .
the aim of this study was to compare women with a history of phpt and a reference population in terms of standard factors predictive of prognosis and ... |
evolutionary comparisons of primary sequence data rely on the generation of a multiple sequence alignment that maximizes the likelihood of positional homology between nucleotides or amino acids by introducing gaps ( 1 ) .
during the course of evolution , functional and structural constraints leave their footprint on ... | we present translatorx , a web server designed to align protein - coding nucleotide sequences based on their corresponding amino acid translations . many comparisons between biological sequences ( nucleic acids and proteins ) involve the construction of multiple alignments .
alignments represent a statement regarding... |
indications include hemodynamic monitoring , total parenteral nutrition , renal replacement therapy and medication prescription , among others .
it is estimated that 5,000,000 central venous lines ( cvls ) are placed each year in the usa .
the rate of mechanical complications during the procedure ranges between 6% ... | introductioneven though advantages of ultrasound line placement seem obvious , many countries do not have easy access to such technology .
this study aims to compare the degree of difficulty in central venous line placement with or without ultrasound and the incidence of complications , and to establish the effect of... |
for older people who can no longer age in place , nursing homes provide an alternative place of residence where care and assistance are offered by professionals .
nursing home residents no longer live in their own home . because a nursing home has a dual nature as an institution and as a home , many health care org... | purpose . to provide an overview of factors influencing the sense of home of older adults residing in the nursing home
. methods . a systematic review was conducted .
inclusion criteria were ( 1 ) original and peer - reviewed research , ( 2 ) qualitative , quantitative , or mixed methods research , ( 3 ) research a... |
salt bridges are known to play an
essential role in the thermodynamic
stability of the folded conformation of many proteins , but their influence
on the kinetics of folding remains largely unknown .
here , we investigate the effect of glu - arg salt bridges on the kinetics
of -helix folding using temperature ... | |
this was a randomized , placebo - controlled , double - blind phase iii study conducted from july 2010 to february 2012 in 148 centers in 12 countries ( canada , china , france , germany , india , korea , mexico , slovakia , slovenia , taiwan , turkey , and the u.s . ) .
the clinical trial protocol was approved by th... | objectiveto investigate the efficacy and tolerability of empagliflozin as add - on to metformin and sulfonylurea in patients with type 2 diabetes.research design and methodspatients inadequately controlled on metformin and sulfonylurea ( hba1c 7 to 10% ) were randomized and treated with once - daily empagliflozin 10 mg... |
however , transplantation is limited not only by organ shortage but also by its unfavorable long - term success due to chronic allograft injury ( cai ) [ 1 , 2 ] . chronic allograft vasculopathy ( cav ) , glomerulosclerosis , and interstitial fibrosis and tubular atrophy ( ifta ) are the dominating histopathological fi... | acute rejection is a major risk factor for chronic allograft injury ( cai ) .
blood leukocytes interacting with allograft endothelial cells during acute rejection were suggested to contribute to the still enigmatic pathogenesis of cai .
we hypothesize that tissue transglutaminase ( tgm2 ) , a multifunctional protei... |
a 4-year - old female child presented with her third episode of fever , headache , and vomiting .
her first such episode was at 3 years and 2 months of age for which she was treated elsewhere as pyogenic meningitis with antibiotics after a cerebrospinal fluid ( csf ) study which was culture negative .
since sh... | aseptic meningitis is characterized by noninfective serous inflammation of the meninges .
it can occur in a recurrent fashion when associated with dermoid and epidermoid cysts due to rupture of cyst contents into subarachnoid space resulting in aseptic chemical meningitis .
bacterial meningitis in association with ... |
thirty adults with parkinson 's disease and 30 neurologically healthy controls individually matched by chronological age ( mean age : 52.03 years , sd = 9.7 ; range from 27 years to 70 years ) , gender ( 19 males and 11 females for both groups , and education ( 6.66% no diploma , 26.6% primary degree,39.9% secondary de... | objectivewhile parkinson 's disease ( pd ) has traditionally been defined by motor symptoms , many researches have indicated that mild cognitive impairment is common in non - demented pd patients .
the purpose of this study was to compare verbal fluency performance in non - demented parkinson 's disease patients with... |
a retrospective cohort study was conducted using the electronic medical and pharmacy records from 1 january 2004 to 1 september 2010 in the veterans health administration ( vha ) veterans integrated service network 16 ( visn 16 ) warehouse .
data format and content were in compliance with the health insurance portabi... | objectivehypoglycemia is associated with failure to show cardiovascular benefit and increased mortality of intensive glycemic control in randomized clinical trials .
this retrospective cohort study aimed to examine the impact of hypoglycemia on vascular events in clinical practice.research design and methodspatients ... |
this study is part of the ongoing finnish diabetic nephropathy ( finndiane ) study , with the aim to identify genetic , clinical , and environmental risk factors for diabetic nephropathy in patients with t1d .
the study was initiated in 1997 , and follow - up data have been collected since 2004 either by re - examina... | objectiveosteoprotegerin ( opg ) is involved in the process of vascular calcification .
we investigated whether opg is associated with the development and progression of diabetes complications in adults with type 1 diabetes ( t1d).research design and methodsserum opg was measured in 1,939 adults with t1d participatin... |
central serous chorioretinopathy ( csc ) is characterized by an idiopathic serous detachment of the neurosensory retina at the macula resulting from deficient pumping and altered barrier function at the level of the retinal pigment epithelium ( rpe ) .
it is characterized by multifocal , irregularly distributed and o... | we hereby report a case of hemorrhagic macular infarction after intravitreal bevacizumab for chronic multifocal central serous chorioretinopathy ( csc ) .
issues regarding safety and adverse effects of bevacizumab are discussed . to the best of our knowledge ,
this is the first reported case of hemorrhagic macular ... |
the detection of early gastric cancer ( egc ) has been aided by increased upper endoscopy screening and the development of endoscopic technology .
the mortality from gastric cancer has therefore decreased due to early detection , that is , increased diagnosis in the early stages .
gastrectomy with lymph node dissec... | abstractsuperficial spreading early gastric cancer ( egc ) is a rare disease that is treated mainly by surgery .
there are few studies on the safety of endoscopic treatment for patients with superficial spreading egc .
the aims of this study were to ( 1 ) investigate the risk of lymph node metastasis of superficial... |
throughout their tropical and subtropical range of distribution , primates occupy a wide variety of different habitats ( fleagle 1999 ) .
few primate species seem to be confined to a single habitat type , e.g. , theropithecus gelada to montane grasslands ( kawai 1979 )
. some others may require the presence of a sp... | in the literature , particularly in primatological books , the peruvian red uakari ( cacajao calvus ucayalii ) is generally considered as a species that is specialized on living in flooded forest , despite existing evidence to the contrary . here
we review all available information on habitats where cacajao calvus uc... |
infectious diseases , especially blood - borne diseases , are major public health problems . the patients undergoing orthopedic surgery , specially orthopedic trauma procedures , as well as patients under other extensive surgeries , might have the chance of transmission of infections such as hepatitis b ( hbv ) , hepat... | background : infectious diseases are major public health problems , among which blood - borne ones
are the most important infections . patients who undergo orthopedic surgery are at higher risk of
transmitting infectious diseases from and to others , due to repeated blood examinations and injection ,
drains secre... |
gold(i )
complexes are very active and selective catalysts for the
addition of nucleophiles on 1,n - enynes .
the most emblematic
transformation in this area is the addition of alcohols and water
on 1,6-enynes 1 ( alkoxy- or hydroxycyclization ) , which
occurs stereospecifically to form adducts 3 in the pre... | a practical aminocyclization of 1,6-enynes
with a wide variety
of substituted anilines , including n - alkyl anilines ,
has been achived by using cationic [ johnphosau(mecn)]sbf6 as a general purpose catalyst .
the resulting adducts can be easily
converted into polycyclic compounds by palladium- and gold - ca... |
hyperbaric oxygen ( hbo ) improves outcome in experimental cerebral ischemia and is therefore emerging as a possible co - treatment for acute ischemic stroke in addition of tissue plasminogen activator ( tpa ) , whose recombinant form is considered the best approved treatment for acute brain ischemia to date ( peplow ,... | normobaric oxygen ( nbo ) and hyperbaric oxygen ( hbo ) are emerging as a possible co - treatment of acute ischemic stroke .
both have been shown to reduce infarct volume , to improve neurologic outcome , to promote endogenous tissue plasminogen activator - induced thrombolysis and cerebral blood flow , and to improv... |
tarantula is a large spider which usually be found in tropical and subtropical areas , but recently has become as pets in worldwide ( 1 ) .
consequently , it is more likely that emergency physicians encounter with patients that hurt with these spiders .
they are nonaggressive arthropods that if to be forced to defe... | tarantulas have recently become as pets in most parts of the world that increased the probability of encountering emergency physicians with patients hurt with these spiders .
their attacks usually do not cause general manifestation , however there are some case reports in this regard . here ,
a 40-year - old man wa... |
anecdotal evidence suggests that metformin titration instructions are not being updated and refill requests are approved without modification of the titration instructions such that the titration instruction is continued for patients newly initiated on metformin.we found a high rate of patients with at least one titrat... | backgroundanecdotal evidence suggests that metformin titration instructions are not being updated and refill requests are approved without modification of the titration instructions such that the titration instructions is continued for patients newly initiated on metformin.methodsthis was a retrospective cohort analysi... |
primary mouse astrocytes cultures were prepared from newborn c57bl/6jolahsd mice brains as previously described . after removing meninges and large blood vessels , brains
cells were cultivated in dulbecco 's modified eagle medium supplemented with 10% fetal bovine serum , 100 u / ml penicillin and 100 g / ml str... | astrocytes , the most abundant glial cell population in the central nervous system , have important functional roles in the brain as blood brain barrier maintenance , synaptic transmission or intercellular communications [ 1 ] , [ 2 ] . numerous studies suggested that astrocytes exhibit a functional and morphological h... |
diagnostic pathology has shown remarkable improvement in recent years , and routine use of immunohistochemistry and electron microscopy has enabled more precise diagnoses . the availability of improved pathological methods for diagnosis of neuroendocrine tumors has also resulted in the recent recognition that these neo... | neuroendocrine carcinomas from an unknown primary site are uncommon .
the authors report on a case of neuroendocrine carcinoma in a perigastric lymph node ( ln ) with no primary site . a 52-year - old male patient with early gastric adenocarcinoma underwent treatment by endoscopic submucosal dissection , and , six mo... |
the estimated new thyroid cancer cases in the united states in 2012 are 56,460 and there are around 1780 deaths from thyroid cancer .
this could be related to the earlier detection of thyroid cancer with the current use of imaging and the use of fna of all suspicious thyroid nodules .
it is important to note that t... | thyroid cancer is among the most common endocrine malignancies .
genetic and environmental factors play an important role in the pathogenesis of differentiated thyroid cancer . both have good prognosis but with frequent recurrences .
cancer staging is an essential prognostic part of cancer management .
there are ... |
the consultation cases are stored in a web - based medical advisory service system ( http://jamoon.pathology.or.kr ) that revealed 1,950 cases sent to the mac from 2003 to 2014 ( fig .
we obtained the following specific information for each case : person who submitted the case , date on which the case was sent , assi... | background : since 2003 , the korean society of pathologists ( ksp ) has been officially providing medical advisory services ( mas ) .
we reviewed the cases submitted to the ksp between 2003 and 2014.methods:in total , 1,950 cases were submitted , most by private health insurance companies .
the main purposes of th... |
atherosclerotic lesions are the leading cause of ischemic stroke worldwide.1 ) the primary factor in the pathogenesis of atherosclerosis is inflammation .
development and progression of an atherosclerotic plaque is mainly regulated by inflammatory and immune mechanisms.2 ) the risk of rupture of atherosclerotic plaqu... | background and objectivesnon - calcified carotid plaques are more unstable than calcified plaques , and they are associated with a higher risk of rupture , thromboembolism , and consequently , stroke .
the purpose of the present study is to compare calcified and non - calcified plaques that cause intermediate carotid... |
pyometra is a rare complication of in vitro fertilization and embryo transfer . in this paper
a 30-year - old female , married for 7 years presented to our clinic with primary subfertility .
she had a history of recurrent ovarian cyst on the left ovary for which both laparoscopic cystectomy and laparotomy had been ... | a 30 year old woman presented 12 days after embryo transfer with lower abdominal pain and orange vaginal discharge .
she was diagnosed to have pyometra .
a conservative management with drainage of the pyometra was followed by an uneventful pregnancy and term delivery .
conservative management in a case of pregnan... |
the tongue plays a major role in swallowing and is essential to ensure normal swallowing
function .
the primary functions of the tongue include food mastication , bolus formation ,
manipulation , and propulsion into the pharynx1 .
moreover , it also contributes to respiration and speech
functions2 . during th... | [ purpose ] the aim of this study was to evaluate the effectiveness of a structured program
of resistance training for the tongue in order to improve swallowing function in stroke
patients with dysphagia . [ subjects and methods ] twenty - seven stroke patients with
dysphagia were randomly divided into two groups... |
after copii vesicles bud from the er , sar1p is released from vesicles when gtp is hydrolyzed , but the inner and outer shells of the coat are largely retained ( fig s1)7 . to define the events that occur after trappi binds to sec23p , we immobilized trappi on beads and asked when copii vesicles lose their ability to b... | how the directionality of vesicle traffic is achieved remains an important unanswered question in cell biology .
the sec23p / sec24p coat complex sorts the fusion machinery ( snares ) into vesicles as they bud from the endoplasmic reticulum .
vesicle tethering to the golgi begins when the tethering factor trappi bi... |
malakoplakia is a rare , chronic , granulomatous inflammatory disease that was first described by michaelis and gutmann in 1902 .
the name " malakoplakia " was derived from the greek " malakos " ( soft ) and " plakos " ( plaque ) in 1903 by von hansemann .
malakoplakia is most commonly found in the urinary tract , ... | malakoplakia is a rare granulomatous disease that occurs commonly in the urinary tract and secondarily in the gastrointestinal tract .
most reported cases of malakoplakia are associated with immunosuppressive diseases or chronic prolonged illness . here , we report a rare case of malakoplakia in a young healthy adole... |
a practical catalytic
method for enantioselective addition
of an allene unit to aldimines is disclosed .
transformations are promoted
by an in - situ - generated b - based catalyst that is derived from a simple ,
robust , and readily accessible ( in multigram quantities ) chiral aminoalcohol .
a range of ar... | |
a 48-year - old man presented with radiating pain to lower thoracic region for two years . a physical examination was unremarkable and he had no significant past medical history .
plain radiographs of the thoracic spine revealed a lobulated geographic osteolytic lesion with a partially sclerotic border involving the ... | an epithelioid hemangioma involving three contiguous bones in continuity has , to the best of our knowledge , not been reported in the literature . a case of a 48-year - old man presented with radiating pain to the lower thoracic region for two years .
a radiograph and ct scan revealed both permeative osteolytic and ... |
the ability to develop and maintain highly functional memory t cells after infection or immunization is a hallmark of the adaptive immune response . however , the human memory t - cell pool is heterogeneous , and comprises distinct populations that can be distinguished based on homing markers and effector functions .
... | immunologic memory is a critical feature of the adaptive immune system to fight recurrent infections .
however , the mechanisms that shape the composition and function of the human memory t - cell pool remain incompletely understood .
we here demonstrate that post - thymic human t - cell differentiation was associa... |
tobacco use is one of the main factors that can lead to cancers of the oral cavity and pharynx .
there are many types of smokeless tobacco products such as chew , chewpoos , chits , chewsky , dip , smokeless tobacco keratosis , flab , chowers , snuff dipper , guy , snus or nass , which can be used by placing and chew... | snus ( nass ) is a form of snuff used in a similar manner to american dipping tobacco , but it does not typically result in a need for spitting .
possible hazards associated with this material include malignant and premalignant lesions in the oral cavity and gastrointestinal tract .
the use of smokeless tobacco has... |
no one is likely to argue with the belief that prompt and appropriate treatment is effective and should be the standard of care .
back in 2001 , emmanuel rivers and colleagues published their landmark study of early goal directed therapy ( egdt ) .
perhaps the central concept behind egdt is that of oxygen debt and ... | this issue 's recently published papers concentrates on early goal directed therapy , starting with new data from the original study through to new studies that may have a major bearing on the treatment of septic shock in years to come . a timely reminder about talking , walking and teaching clinical medicine completes... |
although pervasively widespread in the world , iron is the nutrient with a most pronounced deficiency in humans 1 , 2 many remedial actions have been undertaken ; nevertheless , the problem persists for a number of reasons : unspecific diet supplements , poor dietary food combinations and low bioavailability in the iro... | the objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling .
it comprised two stages : first , the development of the heme iron enriched biscuit filling ; second , the evaluation of the bioavailability of the mineral in fattening piglets .
two groups were selected randomly ... |
as a service to our authors and readers , this journal provides supporting information supplied by the authors .
such materials are peer reviewed and may be re - organized for online delivery , but are not copy - edited or typeset . technical support issues arising from supporting information ( other than missing fil... | we describe a new platform to identify structure - switching dna beacon aptamers , which detect small molecules in a specific manner . by clonally amplifying a dna library designed to fluoresce in response to binding events onto microbeads ,
aptamer beacons can be selected by stringent fluorescence - assisted sorting... |
p - glycoprotein ( abcb1/p - gp ) is a member of the atp binding cassette ( abc ) superfamily and is able to transport a broad range of uncharged and cationic compounds .
the apical localization of p - gp in renal proximal tubule epithelial cells is consistent with its importance in excretory transport into urine . i... | during endotoxemia , the atp - dependent drug efflux pump p - glycoprotein ( abcb1/p - gp ) is upregulated in kidney proximal tubule epithelial cells .
the signaling pathway through which lipopolysaccharide ( lps ) or tumor necrosis factor- ( tnf- ) regulates p - gp expression and activity was investigated further in... |
recent studies of individuals with bipolar disorder suggest that np impairment is prevalent , and intermediate in severity between patients with schizophrenia and healthy comparison participants .
np impairments , particularly deficits in attention , processing speed , episodic memory , and executive functions ( eg ,... | clinicians and clinical neuroscientists are aware that individuals with bipolar disorder are at greater risk for developing serious medical , psychiatric , and substance - use comorbidities as compared with the general population.1,2 less widely appreciated , however , is the observation that hiv infection appears to b... |
pancreatic necrosis complicating severe acute pancreatitis is a challenging scenario in contemporary critical care practice .
patients are often relatively young ( the median age was 55 years [ range 1974 years ] in a recent cohort report ) and postrecovery quality of life should be good , and so there is much to str... | pancreatic necrosis complicating severe acute pancreatitis is a challenging scenario in contemporary critical care practice ; it requires multidisciplinary care in a setting where there is a relatively limited evidence base to support decision making .
this commentary provides a concise overview of current management... |
analysis of a complete population of individuals with a defined cancer diagnosis over a prolonged time period is needed to assess whether new therapeutic strategies have affected the whole population 's survival outcome .
cancers arising from the epithelial lining of the intrahepatic , perihilar , and extrahepatic bi... | background .
cholangiocarcinoma is a cancer with a poor prognosis . in this millennium
there are new diagnostic and therapeutic strategies for these patients . aim .
the aim of this study was to find if these changes influenced survival of individuals with proximal cholangiocarcinoma .
material .
627 individu... |
ajellomyces capsulatus is the holomorphic name for histoplasma capsulatum , the etiological agent of histoplasmosis , a systemic mycosis .
this thermo - dependent dimorphic fungus is soil - borne and in organic nitrogen rich soils fungal growth and sporulation are accelerated .
therefore , places where bird and b... | histoplasmosis is a zoonotic systemic mycosis caused by histoplasma capsulatum .
we report a case of a female canine , 4 years old , presenting multifocal lymphadenitis and skin and gingival lesions , in ecuador . based on cytological , histopathological , histochemical analyses , fungal culture and dna sequencing of... |
evaluation of students competencies is one of the essential tools for assessing success of education programs in accomplishment of its objectives . on the other hand , evaluation is a major determinant of students learning patterns . in other words
some believe that ethical evaluation of medical students should empha... | in this study we discuss our experience of including an ethics objective structured clinical examination ( osce ) station in endocrinology board exam.one osce station on truth telling was developed and a standardized patient was trained for role playing in this station .
based on a pilot study , the evaluation checkl... |
the third - generation aromatase inhibitors ( ais ) , letrozole , anastrozole and exemestane , are now widely accepted as alternatives to tamoxifen as first - line therapy in postmenopausal women with estrogen receptor ( er)-positive advanced breast cancer , because of their improved clinical effectiveness ( nabholtz e... | the third - generation aromatase inhibitors ( ais ) , letrozole , anastrozole and exemestane , are becoming the first choice endocrine drugs for post - menopausal women with breast cancer , since they present greater efficacy when compared with tamoxifen in both adjuvant and metastatic setting .
in particular , sever... |
the dorsal lateral geniculate nucleus ( lgn ) of the thalamus is a small , bi - lateral structure that accepts input from each eye representing the contralateral half of the visual field and projects to the primary visual cortex ( see fig .
the structure comprises six laminae with associated inter - laminar structure... | mapping neuronal responses in the lateral geniculate nucleus ( lgn ) is key to understanding how visual information is processed in the brain .
this paper focuses on our current knowledge of the dynamics the receptive field ( rf ) as broken down into the classical receptive field ( crf ) and the extra - classical rec... |
we retrospectively enrolled 24 cognitively normal subjects , 45 patients with amnestic mild cognitive impairment ( amci ) , 40 with ad , 38 with parkinson s disease - mild cognitive impairment ( pd - mci ) , 31 with pdd , and 22 with dlb from patients seen in the movement disorders and dementia outpatient clinic at a u... | background and purposethe substantia innominata ( si ) contains the nucleus basalis of meynert , which is the major source of cholinergic input to the cerebral cortex .
we hypothesized that degeneration of the si and its relationship to general cognitive performance differs in amyloidopathy and synucleinopathy.method... |
the need for novel approaches to treat infectious diseases at a time of increasing drug resistance and the emergence of new pathogens is obvious and urgent . in recent decades
the problem of drug resistance has been compounded by the emergence of many new infectious diseases like hiv . simultaneously
the population... | there is an obvious and urgent need for novel approaches to treat infectious diseases .
the use of monoclonal antibodies in therapy of infectious diseases is now experiencing renewed interest . during the last 5 years radioimmunotherapy ( rit )
, a modality previously developed only for cancer treatment , has bee... |
desmoid tumours ( dts ) , also known as fibromatoses , are rare soft tissue tumours that result from the abnormal proliferation of fibroblasts in musculo - aponeurotic structures .
they account for 0.03% of all neoplasms and can occur in mesenchymal structures of the limb and limb girdle , intra - abdominally or with... | highlightsintra - abdominal desmoid tumours have a poor prognosis as they can cause intestinal bleeding , obstruction and perforation.the authors report a rare case of small bowel obstruction and perforation secondary to sporadic , synchronous intra - abdominal desmoid tumours.in non - emergency presentations of desmoi... |
it is characterized by a burning , prickling or unpleasant sensation that is usually felt in the hands , arms , or legs but can also occur in other parts of the body , which sometimes leads to sleep disturbance .
paresthesia of limbs may occur from abnormalities in the peripheral nervous system , from direct compress... | objectivethe restless legs syndrome ( rls ) is a common disorder affecting up to 5% to 15% of the general population , in which the incidence increases with age , and includes paresthesia in the legs .
the purpose of this study is to investigate the incidence of rls in spine center and to review clinical manifestatio... |
using dental implants for prosthetic rehabilitation of the edentulous maxilla has become a routine dental procedure . however , low quality of the posterior maxillary bone and a highly pneumatised maxillary sinus can compromise an implant 's survival12 .
implant migration into the maxillary sinus can be caused by ine... | migration of dental implants into the maxillary sinus is uncommon . however
, poor bone quality and quantity in the posterior maxilla can increase the potential for this complication to arise during implant placement procedures .
the aim of this report is to present a dental implant that migrated into the maxillary... |
autoimmunity refers to the immunological destruction of the own cells and tissues due to the failure of the organism to recognize these as self .
autoimmune diseases cover a great variety of symptoms reaching from diffuse inflammatory symptoms involving components of the innate immune system to highly antigen - speci... | innate and adaptive immune responses in neurodegenerative diseases have become recently a focus of research and discussions .
parkinson s disease ( pd ) is a neurodegenerative disorder without known etiopathogenesis .
the past decade has generated evidence for an involvement of the immune system in pd pathogenesis ... |
during the past 30 years , research in the theory of black holes in general relativity has brought to light strong hints of a very deep and fundamental relationship between gravitation , thermodynamics , and quantum theory .
the cornerstone of this relationship is black hole thermodynamics , where it appears that cer... | we review the present status of black hole thermodynamics .
our review includes discussion of classical black hole thermodynamics , hawking radiation from black holes , the generalized second law , and the issue of entropy bounds .
a brief survey also is given of approaches to the calculation of black hole entropy ... |
electrical impedance myography ( eim ) is a four - electrode impedance measurement technique based on the fundamental principle of ohm 's law . in this technique low intensity high frequency alternating current
is injected through the muscle or muscle group of interest via the outer two electrodes and the inner two e... | electrical impedance myography ( eim ) is a noninvasive neurophysiologic technique to diagnose muscle health . besides muscle properties ,
the eim measurements vary significantly with the change of some other anatomic and nonanatomic factors such as skin fat thickness , shape and thickness of muscle , and electrode s... |
from march 2001 to february 2005 , we performed us in 58 patients , mri in 24 patients , and both mri and us in 10 patients for a total of 72 patients ( 63 women and 9 men , age range : 19 - 70 years , average age : 50 years ) who were clinically suspected of having morton neuroma . by review of the pathologic and surg... | objectivethe purpose of this study was to compare the diagnostic accuracy of both ultrasonography ( us ) and magnetic resonance imaging ( mri ) for the assessment of morton neuroma.materials and methodsour study group was comprised of 20 neuromas from 17 patients , and the neuromas were confirmed on surgery following e... |
the important strategy in the prevention of dental caries is by increasing the acid resistance capacity of enamel .
fluoride application and carbon - dioxide ( co2 ) laser have shown a reasonable success to enhance enamel 's resistance to acid attack in the prevention of dental caries .
the anti - cariogenic effect... | aim : the aim of this study was to evaluate the surface / mineral changes on enamel before and after the application of acidulated phosphate fluoride ( apf ) gel , fluoride enhanced hydroxyapatite gel and propolis in conjunction with carbon - dioxide ( co2 ) laser.materials and methods : crowns of 40 human maxillary ce... |
woolly hair nevus is a rare condition , characterized by unruly and tightly coiled hair , which is not genetically determined .
a 5-year - old girl child presented with abnormal patch of hair since 2 years of age .
her parents noticed a single patch of curling and coiling of hair along with altered texture over the... | woolly hair nevus is a rare non - hereditary focal condition characterized by unruly and tightly coiled hair .
it can appear in childhood or adolescence and may be associated with epidermal or melanocytic nevus .
patients presenting with woolly hair must be examined completely to rule out cardiofaciocutaneous and n... |
cl was diagnosed in patients as described elsewhere , according to characteristic lesion morphology , positive skin test results , seropositivity to leishmania antigen , and/or presence of parasites in the lesion .
a total of 58 patients with lcl due to l. braziliensis ( 27 males ; mean age [ sd ] , 29.6 2.3 years )... | we show that increased plasma superoxide dismutase 1 ( sod1 ) levels are statistically significant predictors of the failure of pentavalent antimony treatment for cutaneous leishmaniasis caused by leishmania braziliensis . in leishmania amazonensis infected patients , host sod1 levels can be used to discriminate betwe... |
kounis syndrome is the concurrence of acute coronary syndromes ( acs ) with conditions associated with mast cell activation including allergic or hypersensitivity as well as anaphylactic or anaphylactoid reaction.1)2 ) there have been a few reports on extraordinary causes other than wasp stings leading to a drug - elut... | kounis syndrome is the concurrence of acute coronary syndromes with conditions associated with mast cell activation following an allergic insult .
we report a 56-year - old man who experienced a st - segment elevation myocardial infarction after wasp stings .
the patient presented without signs of anaphylaxis or sh... |
colorectal cancer is a common cancer form in sweden and the incidence is slowly increasing.1 there is a known risk that a patient can have a second coexisting colorectal cancer.2 thus , most treatment guidelines include some type of colon examination in the preoperative work - up to provide the information and enable a... | aim : to assess differences in demography , pathology and prognosis with tumor multiplicity in colorectal cancer.method:a retrospective single centre study of all patients surgically treated for a colorectal cancer during 19992008 ( n = 2524 ) .
patient characteristics , pathology and follow - up data were retrieved ... |
lactic acidosis ( la ) is known to occur in patients of leukemia and lymphoma as a terminal event .
it was first described in patients with acute leukemia by field et al . in 1963 .
diagnostic criteria of la are ph less than 7.35 along with plasma lactate concentration greater than 5 mmol / l .
however , la as th... | lactic acidosis ( la ) has been reported to be associated with high grade lymphoma as a terminal event .
its causes are multi - factorial .
it can either occur due to overproduction of lactic acid by rapidly dividing tumor or due to its underutilization due to involvement of liver by lymphomatous deposits .
the p... |
vascular smooth muscle contraction is activated by an increase in cytosolic free
ca concentration ( [ ca]i ) as a result of ca
entry from the extracellular space and/or ca release from intracellular stores ,
primarily the sarcoplasmic reticulum ( 1 ) .
ca diffuses to the contractile machinery where it binds to ... | smooth muscle contraction is activated primarily by phosphorylation at ser19 of the
regulatory light chain subunits ( lc20 ) of myosin ii , catalysed by
ca2+/calmodulin - dependent myosin light chain kinase .
ca2 + -independent contraction can be induced by inhibition of myosin light chain
phosphatase , which c... |
dermatofibrosarcoma protuberans ( dfsp ) is an uncommon , low - grade cutaneous malignancy that originates from the dermis .
it can occur in any part of the body , but has predilection for the trunk , head and neck region , and the proximal extremities .
the tumor begins as a small bump on the skin surface and then... | abstractdermatofibrosarcoma protuberans ( dfsp ) is a rare , low - grade , cutaneous neoplasm with pronounced tendency for local recurrence .
a case of dfsp that showed direct infiltration into the underlying bone marrow is described . to the best of our knowledge ,
such direct bony involvement by dermatofibrosarco... |
rabbits are animals of a high economic and laboratory value , whereas in poland , principally in scientific and diagnostic research , mixed breed rabbits are generally used .
it must also be added that although researches involving experiments on laboratory animals are conducted on mice , rats and guinea pigs , still... | due to the lack of reference values for immunological parameters in polish mixed breed rabbits , the study was aimed at developing standards for b - cells with cd19 + receptor , and t - cells with cd5 + receptor , and their subpopulations , namely t - cells with receptors cd4 + , cd8 + and cd25 + in peripheral blood of... |
retroperitoneal fibrosis ( rpf ) is a rare disease with peak incidence in the fifth to seventh decades of life .
the symptoms of rpf may be general / nonspecific or localized ( due to replacement or compression of organs ) . yet
, definitive diagnosis can only be made based on biopsy findings . besides , magnetic r... | multifocal fibrosclerosis is a rare syndrome of unknown cause that is characterized by fibrosis involving multiple organ systems .
definitive diagnosis can only be made based on biopsy findings . in this case , the biopsy specimen of the patient demonstrates pulmonary hyalinated granuloma or sclerosing mediastinitis ... |
pain is a noxious and a harmful felling of a living organism that arising from inflamed or injured tissues .
otherwise , responses to noxious stimuli may be enhanced ( hyperalgesia ) or normally innocuous stimuli .
more studies confirm that in normal conditions , a fibers are mainly relevant with non - noxious inpu... | objective(s):analgesic effects of oxytocin and it 's the other physiological effects were well - known .
the aim of present study was determination of nitric oxide role on analgesic effects of oxytocin in mice.materials and methods:216 male albino mice were divided randomly into two experimental groups , tail flick a... |
depression is among the commonest of psychiatric disorders , and inflammatory mechanisms are among the very many mechanisms that have been suggested to drive its pathophysiology .
interferon - related depression is important in medicine and neurology , and the last decade has seen a spurt of research in the field .... | abstract : backgrounddepression is among the commonest of psychiatric disorders , and inflammatory mechanisms have been suggested to play a role in its pathophysiology .
interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms .
interferons are used in the treatment of ... |
posterior cortical atrophy ( pca ) is a neurodegenerative syndrome characterized by progressive decline in visual processing , literacy , numeracy , and other functions that depend on parietal , occipital , and occipitotemporal brain regions ( benson et al . , 1988 ; kas et al . ,
most individuals with pca have alz... | posterior cortical atrophy ( pca ) is a neurodegenerative syndrome characterized by impaired higher visual processing skills ; however , motor features more commonly associated with corticobasal syndrome may also occur .
we investigated the frequency and clinical characteristics of motor features in 44 pca patients a... |
deep hypothermic circulatory arrest ( dhca ) has become a worldwide specialized technique within cardiopulmonary bypass for adult aortic arch repair .
this technique provides complete visualization of the aortic arch in a bloodless field with profound neuroprotection through deep hypothermia [ 1 , 2 ] .
deep hypoth... | introductiondeep hypothermic circulatory arrest for adult aortic arch repair is still associated with significant mortality and morbidity . furthermore , there is still significant variation in the conduct of this complex perioperative technique .
this variation in deep hypothermic circulatory arrest practice has not... |
we report a genome - wide association study to iron status .
we identify an association of snps in tpmrss6 to serum iron ( rs855791 , combined p = 1.51020 ) , transferrin saturation ( combined p = 2.21023 ) , and erythrocyte mean cell volume ( mcv , combined p = 1.11010 ) .
we also find suggestive evidence of assoc... | |
although the most critical risk factor for development of copd is cigarette smoking , 20%30% of copd patients have never smoked.13 occupational exposures and air pollution have been associated with development and progression of copd.4,5 inhalation of airborne pollutants , including oxidant gases such as ozone , nitrog... | backgroundheavy metal exposure may contribute to inflammation in the lungs via increased oxidative stress , resulting in tissue destruction and obstructive lung function ( olf ) . in this study
, we evaluated the relationship between lead and cadmium levels in blood , and lung function in the korean population.method... |
the association of increased serum levels of acute - phase proteins with the progression of atherosclerosis and with the occurrence of atherosclerosis - related adverse events , such as coronary heart disease and myocardial infarction ( mi ) , has been well documented in several epidemiological studies.1 - 6 ) currentl... | background and objectivespentraxin 3 ( ptx3 ) was shown to be elevated in the acute phase of acute myocardial infarction ( ami ) and to have prognostic significance in ami patients .
the aim of this study was to estimate whether the value of ptx3 could be used as a prognostic biomarker , with the global registry of a... |
hypertensive disease , in which there is persistent pathologic elevation of arterial pressure and increased total peripheral resistance , is associated with vascular lesions in the brain , heart , kidneys , and eyes .
elevation of systemic blood pressure causes both focal and generalized retinal arteriolar constricti... | purpose .
we report a case of hypertensive choroidopathy with bilateral serous retinal detachments .
patient .
a 50-year - old man underwent bilateral serous retinal detachments .
retinal arteriolar narrowing , vascular tortuosity , and arteriovenous nicking were identified in both eyes .
the blood pressure w... |
exposure to disinfection by - products ( dbps ) of drinking water is multiroute and occurs in households serviced by municipal water treatment facilities that disinfect the water as a necessary step to halt the spread of waterborne infectious diseases .
biomarkers of the two most abundant groups of dbps of chlorinati... | |
it is characterized by a quick loss of renal function , which develops over hours to days .
problems causing obstruction in the urinary system are considered under the topic of post - renal failure .
different precipitating factors that cause obstruction throughout the ureteral trace , urine bladder tumors , and ur... | acute renal failure is characterized by rapidly disruption in kidney function and postrenal causes typically result from obstruction of urinary flow .
multiple etiologies were described for acute renal failure , but labial fusion in postmenopausal female is a quite rarely encountered pathology among postrenal causes ... |
scheuermann s disease ( juvenile kyphosis dorsalis ) is a structural kyphosis of the thoracic spine initially described by scheuermann in 1921 .
it occurs commonly in adolescents ( 0.48.3% of the general population ) and in most cases is characterized by minimal deformity and few clinical symptoms .
the purpose of ... | we present the case of a 14-year - old male with scheuermann s disease and significant neurological deficit due to thoracic disk herniation at the apex of kyphosis .
he was treated with an anterior decompression , anterior and posterior fusion in the same setting using plate , cage and a segmental instrumentation sys... |
conventional endodontic treatment has experienced an impressive progression over the last decades basically through a more efficient desinfection of the root canal system supported by new irrigation and instrumentation methods combined with increasing information about morphological complexities .
the success of root... | the aim of the present roentgenographic in vitro study was to determine the initial straight length from the cemento - enamel junction ( cej ) to the appearance of a root canal curvature in human mandibular premolars .
a total number of 282 mandibular premolars were examined .
exclusion criteria comprised root cari... |
the kaiser permanente northern california diabetes registry ( also referred to here as the registry ) is a well - characterized population , maintained continuously since 1993 , that has been the basis for extensive epidemiological research ( 1113 ) .
registry eligibility is based on multiple sources of data , includ... | objectiveto identify the range of glycemic levels associated with the lowest rates of complications and mortality in older diabetic patients.research design and methodswe conducted a retrospective cohort study ( 20042008 ) of 71,092 patients with type 2 diabetes , aged 60 years , enrolled in kaiser permanente northern ... |
photosystem
ii ( psii ) offers a biological and sustainable route
of photochemical water oxidation to o2 and can provide
protons and electrons for the generation of solar fuels , such as h2 .
we present a rational strategy to electrostatically improve
the orientation of psii from a thermophilic cyanobacterium... | |
diabetes mellitus type 2 ( t2 dm ) is a chronic disease that has been increasing globally over
the past 2 decades including in thailand1 .
it is a significant health problem with microangiopathy and macroangiopathy resulting in
many complications , i.e , neuropathy2 ,
retinopathy3 , nephropathy4 , and coronary ... | [ purpose ] obesity and hyperglycemia play roles in the impairment of pulmonary function in
type 2 diabetes mellitus ( t2 dm ) patients .
low - intensity exercise is known to reduce body
fat and improve hyperglycemia .
the arm swing exercise ( ase ) , a low - intensity exercise , is
easy and convenient to per... |
the results of the latest large trial in patients with cardiogenic shock ( cs ) , namely the triumph trial , were recently published in journal of the american medical association . about 6 to 9% of myocardial infarctions ( mis ) , mostly with st elevation , is complicated by cs , which is the leading cause of death . ... | the triumph study , recently published in journal of the american medical association , was a prospective randomized placebo - controlled trial testing the hypothesis that tilarginine ( a non - specific inhibitor of nitric oxide synthase ) , when compared with placebo , would reduce 30-day mortality by 25% in patients ... |
patient 1 was a 74-year - old italian man who came to the emergency department ( ed ) of vittorio emanuele hospital in catania , italy , in july 2012 .
patient 2 was 65-year - old german woman who arrived in rome from frankfurt in march 2011 and came directly from the airport to the ed of the university of rome medic... | we report 3 cases of fulminant hemorrhagic pneumonia in previously health patients .
sudden - onset hemoptysis and dyspnea developed ; all 3 patients and died < 12 h later of massive pulmonary bleeding , despite aggressive supportive care .
postmortem analysis showed that the illnesses were caused by group a strept... |
bladder cancer is the ninth most common cancer worldwide , with 380,000 new cases reported annually .
the ratio of male : female bladder cancer patients is 3.8:1 . according to data from the united states ,
15,250 deaths from bladder cancer are expected to occur in 2013 . moreover , according to the surveillance , ... | purposethe purpose of this study was to retrospectively investigate the contribution of 18f - fluorodeoxyglucose - positron emission tomography / computed tomography ( 18f - fdg - pet / ct ) to detection of metastatic bladder cancer.materials and methodsthe present study included 79 patients ( 69 men and 10 women ) und... |
punctate inner choroidopathy ( pic ) , an idiopathic primary choriocapillaritis , affects especially young myopic women .
multiple yellowish white dots ( 100 - 300 m ) can aggregate in the inner choroid or retinal pigment epithelial layer , resulting in exudative retinal detachment .
choroidal neovascularization ( ... | purposechoroidal neovascularization ( cnv ) associated with punctate inner choroidopathy ( pic ) is a rare clinical entity , yet still a challenge for medical treatment .
a case of a young myopic woman developing cnv secondary to unilateral pic is presented .
clinical morphology , diagnostic procedure and follow - ... |
during january august 2013 , we collected rodents and shrews in jiaonan county , shandong province , china ( 1193012030e , 35353608 n ) .
the animals were trapped once a month by using mouse traps baited with peanuts ; a different trap site was used each month .
the traps were set before sunset outside human dwell... | to evaluate the role of small mammals as hosts of severe fever with thrombocytopenia syndrome virus ( sftsv ) , we tested serum samples from rodents and shrews in china , collected in 2013 .
sftsv antibodies and rna were detected , suggesting that rodents and shrews might be hosts for sftsv . |
urinary stone disease , or urolithiasis , is one of the most common afflictions of modern society.1 it is a common urologic disease with prevalence of about 1%20% that is increasing throughout the world .
urinary stone incidence in iran is high.2,3 the highest incidence was reported in ilam province , western iran , ... | purposethe aim of this study was to evaluate the biochemical stone composition in general population of qom province , central iran , and its relationship with high tap water hardness.materials and methodsin a prospective study , from march 2008 to july 2011 , biochemical analysis of urinary stones in patients living i... |
with an ageing population , the prevalence of dementia will continue to rise in the coming decades , placing a high burden on social and economic resources .
since effective treatments are lacking , prevention of dementia deserves high priority [ 1 , 2 ] . in recent years
, a relationship has been found between vas... | backgroundserum n - terminal pro - brain natriuretic peptide ( nt - probnp ) is regarded as a sensitive marker of cardiovascular disease .
vascular disease plays an important role in cognitive impairment.methodin 447 elderly patients with mental illness , serum nt - probnp level and the presence or absence of vascula... |
a glomus body , or glomus apparatus , is a neuromyoarterial structure in the dermis layer of the skin , involved in body temperature regulation .
it consists of an arterio - venous shunt surrounded by a capsule of connective tissue . in response to sympathetic stimuli
, glomus body induces vasoconstriction in the s... | the glomus tumor of the peripheral nerve is one of the mesenchymal tumors originating in the epineurium , and is extremely rare .
a 56-year - old man presented complaining of lancinating pain on the left thigh , which was provoked by pressure or exercise .
subsequent image study revealed a mass in the femoral nerve... |
forensic odontology is a legal field of dentistry , which deals with the proper handling and examination of dental evidence and with the proper evaluation and presentation of dental findings in the interest of justice .
a working classification about the interrelationship of nine individual dental specialties with fo... | background : there is a paucity of information about the relationship of forensic odontology with various dental specialties in the articles published in the journal of forensic odonto - stomatology .
this study aimed to find the relationship of forensic odontology with various dental specialties in the articles publ... |
the prevalence of type 2 diabetes mellitus ( t2 dm ) has significantly increased worldwide in the past 25 years [ 1 , 2 ] .
dr is one of the most common microvascular complications of diabetes mellitus ( dm ) and is the leading cause of visual impairment and blindness in working - aged people . in recent years
, th... | diabetic retinopathy ( dr ) is the leading cause of visual impairment and blindness in working - aged people .
several studies have suggested that glomerular filtration rate ( gfr ) was correlated with dr .
this is a hospital - based study and the aim of it was to examine the relationship between the gfr and dr in ... |
non - melanoma skin cancer ( nmsc ) affects close to 1 million americans annually .
although metastases are rare , their high incidence and frequent recurrence in affected individuals make nmscs the 4th most costly cancers of the medicare population .
nsmc is comprised of two subtypes squamous cell carcinomas ( sc... | to determine the relationship between 25(oh ) vitamin d levels and non - melanoma skin cancer ( nmsc ) , we performed a nested case control study in ambulatory , elderly men enrolled in the osteoporotic fractures in men ( mros ) study . health habit and medical history , including self - reported history of nmsc were ... |
the term dementia describes a collection of symptoms including a decline in memory , reasoning and communication skills and a gradual loss of skills needed to carry out every day living. approximately 700 000 people in the uk suffer from dementia , costing the economy 17 billion a year . over the next 30 years
the... | background.depression is identified as a risk factor for dementia .
little research has been carried out on the importance of anxiety , despite strong evidence of co - morbidity with depression.objective.to examine the association of anxiety and depression with future dementia diagnosis.methods.this case - control st... |
the current standard of treatment for locally advanced rectal cancer ( uicc stages ii and iii ) includes a 5-fluorouracil ( 5-fu)-based preoperative radiochemotherapy ( rct ) , total mesorectal excision , and postoperative chemotherapy [ 1 , 2 ] .
several randomized clinical trials during the last decades have demons... | leukocytoclastic vasculitis is a multicausal systemic inflammatory disease of the small vessels , histologically characterized by inflammation and deposition of both nuclear debris and fibrin in dermal postcapillary venules .
the clinical picture typically involves palpable purpura of the lower legs and may be associ... |
wilson 's disease ( wd ) is an autosomal recessive disease , involving a defect of copper transport by hepatic lysosomes , caused by mutations in the atp7b gene that lies on chromosome 13q14.3 .
reduced biliary excretion of copper results in a net positive copper balance and copper deposition in the liver , brain , k... | therapeutic outcome of wilson 's disease significantly depends upon its early recognition . as
wilson 's disease is a rare disorder with protean manifestations , its diagnosis and subsequent treatment are often delayed .
we elaborate here the case of a young boy who had initially presented with psychiatrc symptoms ... |
sodium bromate and potassium bromate are strong oxidants that are widely used in hair permanent wave neutralizers , reagents of printing or dyeing and other chemical processes .
hair wave permanent neutralizing solutions typically contain 2 - 10% sodium or potassium bromate , which are colorless , odorless and tastel... | despite the well - established nature of bromate - induced ototoxicity , cochlear implantation after bromate intoxication has been rarely documented . we hereby present a case of a 51-year - old female deafened completely after bromate ingestion .
her hearing was not restored by systemic steroid treatment and hearing... |
the local institutional review board approved this retrospective study , and patients provided a written informed consent for the procedure .
we def ined outpatient day - care management as a clinical process where the patients get a procedure on the day of admission and are subsequently get discharged on the same da... | purposeday - care management of unruptured intracranial aneurysms can shorten hospital stay , reduce medical cost and improve outcome .
we present the process , outcome and duration of hospital stay for the management of unruptured intracranial aneurysms via a neurointervention clinic in a single center during the pa... |
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