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fundus examination revealed a round - shaped hypopigmented macular lesion including a few yellow spots in the fovea [ fig .
fa showed a macular transmission hyperfluorescent ring in which patchy hyperfluorescent and normofluorescent areas existed [ fig .
fundus autofluorescence imaging showed scattered patchy hyper... | a 20-year - old man applied with vision loss in the left eye .
right eye examination was unremarkable .
best - corrected visual acuity ( bcva ) in the left eye was 20/200 .
fundus examination revealed a few yellow spots within a round - shaped macular lesion .
autofluorescence imaging showed hyperautofluorescen... |
episodic angioedema with eosinophilia ( eae ) , originally described by gleich et al . in 19841 ) , is a syndrome characterized by recurrent episodes of angioedema , fever , leukocytosis , eosinophilia , elevated serum igm , increased body weight , and a benign clinical course lacking any internal organ involvement .
... | episodic angioedema with eosinophilia ( eae ) is characterized by recurrent angioedema , peripheral eosinophilia , elevated serum igm , fever , weight gain , and a benign course lacking any internal organ involvement .
dozens of cases of the nonepisodic variant ( neae ) , which is limited to a single attack , have be... |
antimicrobial agents are both a boon and
threat to human health ,
with questions about their proper design , useful application , disposal
and regulatory framework looming large for scientists , the medical
community , regulators and consumers of antiseptic personal care products . in the late 1930s and early 1... | the polychlorinated
aromatic antimicrobials triclosan and
triclocarban are in widespread use for killing microorganisms indiscriminately ,
rapidly , and by nonspecific action .
while their utility in healthcare
settings is undisputed , benefits to users of antimicrobial personal
care products are few to non... |
severe fever with thrombocytopenia syndrome ( sfts ) is an emerging tick - borne disease that was first reported in china in 2011 .
there have been 2,047 cases reported in china , while 53 cases and 36 cases have been reported in japan and korea , respectively .
it is known that sfts occurs from may to august when ... | severe fever with thrombocytopenia syndrome ( sfts ) is an emerging tick - borne disease .
the primary symptoms associated with sfts are fever , thrombocytopenia , leukopenia , nausea , and vomiting .
disease progression shows high mortality rate accompanied with multiple organ failure , bleeding tendency , and alt... |
interference in the balance between the environmental production of reactive oxygen species ( ros ) , including hydroxyl radicals ( oh ) and hydrogen peroxide ( h2o2 ) , and the ability of biological systems to readily detect and detoxify them , or repair the resulting damage , are defined as oxidative stress .
highl... | bacteria are permanently in contact with reactive oxygen species ( ros ) , both over the course of their life cycle as well that present in their environment .
these species cause damage to proteins , lipids , and nucleotides , negatively impacting the organism . to detect these ros molecules and to stimulate the exp... |
the response to interferon - based therapy for patients with compensated cirrhosis due to hepatitis c has been evaluated in several trials , both as the focus of prospective study , as well as in subgroup ( post hoc ) analyses of large registration trials . despite the improved efficacy of peginterferons , the sustaine... | despite the improved efficacy of peginterferons , the rate of sustained virologic response is suboptimal in cirrhotic patients , relative to non - cirrhotic patients .
however , the treatment of patients with compensated cirrhosis has recently been encouraged by expert panels .
interferon - based therapy may provid... |
dermoscopy has become an integral part of diagnosing scalp disorders and differentiating cicatricial from noncicatricial alopecia .
discoid lupus erythematosus ( dle ) is seen in 50 to 85% of patients with cutaneous lupus erythematosus , and scalp involvement is most often the presenting symptom .
accurate and rapi... | dermoscopy has become an integral part of diagnosing scalp disorders including discoid lupus erythematosus ( dle ) .
follicular keratotic plugs are a marker of dle and correlate with the hyperkeratosis and plugging of the follicular ostia with keratotic material .
they may be present in acute or chronic lesions and... |
simulating the dynamics
of molecular systems on a digital computer
requires that the equations of motion be discretized .
the resulting
discrete - time integration algorithm that governs the updates of particle
positions and velocities will necessarily have properties that differ
from the continuous equatio... | when simulating molecular systems
using deterministic equations
of motion ( e.g. , newtonian dynamics ) , such equations are generally
numerically integrated according to a well - developed set of algorithms
that share commonly agreed - upon desirable properties .
however , for
stochastic equations of motio... |
computed tomography ( ct ) angiography is an established modality for evaluation of a variety of peripheral vascular disorders including peripheral arterial diseases ( pad ) and peripheral vascular malformations . besides increasing detector rows allowing shorter acquisition time ,
an equally important component of t... | multidetector computed tomography angiography ( mdcta ) has become a well - established modality for limb angiography for a variety of indications .
the technique of mdcta depends on the scanner features including the number of detector rows , rotation speeds and single or dual source energy .
integral to a diagnos... |
strains , plasmids , and oligonucleotides used in this study are shown in supplementary table 2 .
d. dadantii competition assays on chicory were carried out as described in supplementary methods . ec93 and d. dadantii 3937 cdia - ct - cdii deletions and cdia chimeras
the 3 end of cdia and all of cdii from upec 536 ... | summary paragraphbacteria have developed mechanisms to communicate and compete with one another in diverse environments 1 .
a new form of intercellular communication , contact - dependent growth inhibition ( cdi ) , was discovered recently in escherichia coli
2 .
cdi is mediated by the cdib / cdia two - partner s... |
lipoid pneumonia ( lp ) is a rare inflammatory disease of the lung parenchyma caused by accumulation of fatty oily material in the alveoli .
exogenous lipoid results from aspiration or inhalation of mineral , vegetable , or animal oil into the peripheral lung .
children can aspirate large amounts of different oily ... | acute lipoid pneumonia ( lp ) in children is a rare disorder caused by the aspiration of oil - based substances and is difficult to diagnose due to non - specific clinical symptoms and radiological findings .
we report the case of a 5-month - old male infant with acute lp caused by accidental aspiration of a large am... |
x - ray digital subtraction angiography ( dsa ) has been the gold standard investigation in the evaluation of intracranial aneurysms both before and after surgical clipping [ 13 ] .
two - dimensional ( 2d ) dsa has been used over the years and has been supplemented by three - dimensional ( 3d ) rotational angiography... | introduction . 3d
rotational angiography ( ra ) is indispensable for evaluation of intracranial aneurysms , providing infinite viewing angles and defining the aneurysm morphology .
its role in follow - up of clipped aneurysms remains unclear .
we aimed to compare the aneurysm residue / recurrence detection rate o... |
male sprague dawley rats were made diabetic with a single intraperitoneal injection of 75 mg / kg stz ( sigma , st louis , mo ) .
insulin implants ( two linplant implants ; linshin canada , toronto , on , canada ) were placed subcutaneously into stz - diabetic rats after 18 weeks of diabetes and kept in place for 4 w... | objectiveimpairments in mitochondrial function have been proposed to play a role in the etiology of diabetic sensory neuropathy .
we tested the hypothesis that mitochondrial dysfunction in axons of sensory neurons in type 1 diabetes is due to abnormal activity of the respiratory chain and an altered mitochondrial pro... |
the patient can be positioned supine on a radiolucent operating room table or placed in the beach chair position .
fluoroscopic images are obtained to confirm visualization with the image intensifier prior to prepping and draping the patient 's shoulder , neck , and arm .
full anesthetic relaxation allows for less ... | fixation of proximal humerus fractures with precontoured , fixed angle devices has improved operative management of these difficult injuries , particularly in patients with osteoporosis .
however , recent data has revealed that fixation with these constructs is not without complications , particularly screw cut - out... |
cyclin - dependent kinase non - small cell lung cancer pumilio rna - binding family member 1/2 e3 ubitiquitin ligase
oncosuppressor mirnas have emerged as powerful post - transcriptional inhibitors of genetic programs controlling cancer cell proliferation , survival , invasion , metastasis , and stemness . moreover ,... | oncosuppressor mirnas inhibit cancer cell proliferation by targeting key components of the cell cycle machinery . in our recent report
we showed that mir-340 is a novel tumor suppressor in non - small cell lung cancer .
mir-340 inhibits neoplastic cell proliferation and induces p27kip1 by targeting multiple transla... |
this work was supported by feder funds and fondo social europeo through grants from the junta de andaluca ( grants cvi-7335 to t.k . and cvi-7391 to m.eu ) and
the spanish ministry for economy and competitiveness ( grants bio2010 - 16937 and bio2013 - 42297 to t.k ; grant bfu2010 - 17946 to m.eu ) . | abstractapart from inter - bacteria communication quorum sensing ( qs ) mechanisms also enable inter - domain interactions . to interfere with bacterial qs
, plants were found to secrete compounds ; most of which of unknown identity .
we have identified the plant compound rosmarinic acid ( ra ) to modulate pseudomo... |
over two thirds of us residents are overweight and about one - third are obese.1 approximately 11% of the adult us population has type 1 or type 2 diabetes , and this number is expected to double by 2050.2,3 type 2 diabetes mellitus is the most common form of diabetes , accounting for 90%95% of all cases .
it is more... | type 2 diabetes and obesity commonly occur together .
obesity contributes to insulin resistance , a main cause of type 2 diabetes .
modest weight loss reduces glucose , lipids , blood pressure , need for medications , and cardiovascular risk .
a number of approaches can be used to achieve weight loss , including ... |
the success of restorative procedures depend on effective removal of infected dentin prior to the placement of the restorative material .
failure to mechanically remove any carious portion and not being able to achieve complete disinfection may lead to microleakage , increased pulp sensitivity , pulpal inflammation ,... | introduction : the main objective of adhesive dentistry is to create an effective , durable union between the tooth structure and restorative material .
however , degradation of adhesive dentine interface remains largely responsible for the relatively short lifetime of tooth colored resin restoration.aim:the aim of t... |
current treatment strategies for breast cancer depend on disease stage , tumor grade , tumor hormone receptor status , and whether there is over - expression or amplification of the human epidermal growth factor receptor ( her ) . because of the availability of numerous agents , patients with breast cancer may receive ... | the epothilone analog ixabepilone exhibits reduced susceptibility to several important tumor survival mechanisms that limit the efficacy of taxanes and anthracyclines . as a single agent
, ixabepilone has shown promise in metastatic breast cancer when anthracyclines , taxanes , or capecitabine have failed ; and in ea... |
it is caused by a deficiency of both hexosaminidase ( hex ) a and b , resulting in accumulation of glycosphingolipids and oligosaccharides in the brain .
it has three clinical subtypes ( infantile , juvenile , and adult forms ) and represents around 7% of cases among all the lysosomal storage disorders .
the infant... | sandhoff disease is a neurodegenerative disease caused due to deficiency of hexosaminidase ( hex ) a and b. a 1-year - old male child presented with regression of milestones , exaggerated startle response , decreased vision , and seizures from 6 months of age .
the child had coarse facies without hepatosplenomegaly .... |
implantable cardioverter defibrillator ( icd ) and cardiac resynchronization therapy ( crt ) devices have become the mainstay of treating persistent systolic heart failure in addition to guideline directed medical therapy . many of these devices are implanted in patients with congestive heart failure with new york hear... | backgroundheart failure hospitalizations ( hfhs ) cost the us health care system ~$20 billion annually . identifying patients at risk of hfh to enable timely
intervention and prevent expensive hospitalization remains a challenge .
implantable cardioverter defibrillators ( icds ) and cardiac resynchronization device... |
although several surgical interventions have been developed , mortality and complications related to surgical management remains high , especially with respect to trans - ventricular approach .
ventricular incision also has several disadvantages : increased postoperative bleeding , ventricular malfunction , and ventr... | ventricular septal rupture ( vsr ) is a disastrous mechanical complication of myocardial infarction .
although several surgical interventions have been developed , mortality due to surgical management remains high , especially in the case of posterior vsr .
we report a successful case of repair of posterior vsr usi... |
a 24-year - old male was admitted to our hospital with a 1 week history of progressive headache and fever .
his previous medical history was clear . on the neurologic examination , his mental status was normal without focal neurological deficits .
lumbar cerebrospinal fluid ( csf ) analysis showed pleocytosis , inc... | a 24-year - old man with tuberculosis meningitis developed acute paraplegia and sensory disturbances 5 weeks after receiving conventional antituberculous therapy . magnetic resonance imaging revealed an intradural extramedullary long segmental mass mimicking en plaque meningioma at the t2-t6 vertebrae levels .
prompt... |
such changes may be found in the crown either in the form of anomalous cusps , or in an increased number of roots , which in some instances are associated with an anomalous cusp .
the term paramolar tubercle has been applied to any stylar anomalous cusp , supernumerary inclusion or eminence occurring on the buccal ... | the objective of this article is to increase our understanding of the root canal system of the anomalous structures like paramolar tubercles .
the knowledge of the internal anatomy of the paramolar tubercles is very important as they influence the treatment modalities and associated problems in many dental discipline... |
piperine , a nitrogenous pungent substance , is an alkaloid found in important and oldest spices , namely , piper nigrum ( black peppers ) and piper longum ( long peppers ) .
. stated that piperine is naturally occurring organic compound that belongs to family piperaceae .
the fruits of piperine possess antidepre... | molecularly imprinted polymer ( mip ) microspheres for piperine were synthesized by precipitation polymerization with a noncovalent approach . in this research piperine was used as a template , acrylic acid as a functional monomer , ethylene glycol dimethacrylate as a cross - linker , and 2,2-azobisisobutyronitrile ( a... |
choriocarcinoma is a highly malignant gestational trophoblastic disease associated with high urine and serum -hcg levels .
to date , few studies have reported pulmonary embolism ( pe ) and pulmonary hypertension caused by choriocarcinoma of the pulmonary artery . here , we report a young female patient with choriocar... | abstractcases of pulmonary embolism and pulmonary artery hypertension caused by choriocarcinoma represent a rare clinical emergency .
we report a case of a 25-year - old woman who presented with pulmonary embolism and hypertension and died soon after complete pulmonary embolectomy .
a related literature review reve... |
wegener 's granulomatosis is an uncommon multi - organ disease first categorized as a distinct syndrome by friedreich wegener in 1936 [ 1 - 3 ] the hallmarks of this potentially fatal disorder are necrotizing granulomatous inflammation involving the upper and lower respiratory tract , glomerulonephritis , and vasculiti... | wegener 's granulomatosis is a rare multi - system disease characterized by the classic triad of necrotizing granulomas affecting the upper and lower respiratory tracts , disseminated vasculitis and glomerulonephritis .
oral lesions as a presenting feature are only encountered in 2% of these cases .
hyperplastic gi... |
ticks were sampled in the villages of diiso and el - humow and at the livestock market and abattoirs in garissa district , north eastern province of kenya , during april may 2008 ( figure ) .
garissa district is in a semi - arid to arid ecologic zone that receives sporadic rainfall from march to may ; vegetation con... | as part of ongoing arbovirus surveillance , we screened ticks obtained from livestock in northeastern kenya in 2008 to assess the risk for human exposure to tick - borne viruses .
of 1,144 pools of 8,600 hyalomma spp .
ticks screened for congo - crimean hemorrhagic fever virus by reverse transcription pcr , 23 pool... |
yeastract ( yeast search for transcriptional regulators and consensus tracking ; www.yeastract.com ) was originally proposed ( 1 ) to make publicly available up - to - date information on documented regulatory associations between tfs and target genes , as well as between tfs and dna binding sites , in saccharomyces ce... | the yeast search for transcriptional regulators and consensus tracking ( yeastract ) information system ( www.yeastract.com ) was developed to support the analysis of transcription regulatory associations in saccharomyces cerevisiae .
last updated in september 2007 , this database contains over 30 990 regulatory asso... |
massive intravascular and intracardiac thrombosis after separation from cardiopulmonary bypass ( cpb ) is a very rare , but dreaded complication . preexisting thromboembolic diseases or acquired coagulation disorders ( related to antifibrinolytic therapy )
we report the occurrence of severe acute massive intracardiac... | massive intracardiac and intravascular thrombosis is a rare complication following cardiopulmonary bypass ( cpb ) .
most of the cases of the disseminated thrombosis have been reported in patients undergoing complex cardiac surgeries and those receiving antifibrinolytic agents during cpb .
we report the occurrence o... |
a 42-year - old female visited our emergency room ( er ) with complaints of acute , diffuse abdominal pain .
she had been treated for three days at a local clinic because of fever and right upper quadrant pain .
the laboratory findings showed mild leukocytosis ( 11.210 cells/l ) and an elevated c - reactive protein... | we report here on an uncommon case of peliosis hepatis with hemorrhagic necrosis that was complicated by massive intrahepatic bleeding and rupture , and treated by emergent right lobectomy .
we demonstrate the imaging findings , with emphasis on the triphasic , contrast - enhanced multidetector ct findings , as well ... |
operators hands and knives that are not sterile come into contact with the carcass and transfer bacteria to its surface , during bleeding , pelting , evisceration ( hadley et al . , 1997 ) and post - mortem inspection ( walker et al . , 2000 ) .
the most frequently involved step among the above mentioned procedures i... | the aim of the study was to evaluate the hygienic status of sheep carcasses skinned with two different procedures , the pulling down and y cut methods , with and without the use of compressed filtered air inflation . five sheep carcasses per day for each of the four skinning methods considered
were sampled on ten dif... |
tin oxide ( sno2 ) is considered an important wide - bandgap n - type semiconductor which has received a great deal of attention over the past few years due to its high transparency in the visible part of the spectrum and sensitivity to certain gases which make it technologically important for optoelectronic devices [ ... | we have studied the optical properties and carrier dynamics in sno2nanowires ( nws ) with an average radius of 50 nm that were grown via the vapor
liquid solid method .
transient differential absorption measurements have been employed to investigate the ultrafast relaxation dynamics of photogenerated carriers in th... |
a 58-year - old caucasian woman was admitted to the gynecology out - patient department for management of increasing abdominal distension and sustained pain in the right bottom quadrant of her abdomen that had been ongoing for 3 months , was independent of activities , and was without any signs of neurovascular deficit... | neurilemomas are benign usually encapsulated nerve sheath tumors derived from the schwann cells .
these tumors commonly arise from the cranial nerves as acoustic neurinomas but they are extremely rare in the pelvis and the retroperitoneal area ( less than 0.5% of reported cases ) , unless they are combined with von r... |
insomnia is a highly common disorder , which is experienced by almost everybody , at least at advanced age , and becomes chronic in about 10% of the population . because of the transient nature of its milder forms , its importance is frequently underrated . on the other hand ,
the treatment of severe sleep disturbanc... | hypnotic effects of melatonin and melatoninergic drugs are mediated via mt1 and mt2 receptors , especially those in the circadian pacemaker , the suprachiasmatic nucleus , which acts on the hypothalamic sleep switch .
therefore , they differ fundamentally from gabaergic hypnotics .
melatoninergic agonists primarily... |
to begin this procedure , we ensure that all scuva components have sufficient battery power , recording tape ( for the high - definition or hd video camera ) , and function properly . depending on the flows to be measured , select video camera resolution and frame rates that yield best results for digital particle imag... | the ability to directly measure velocity fields in a fluid environment is necessary to provide empirical data for studies in fields as diverse as oceanography , ecology , biology , and fluid mechanics .
field measurements introduce practical challenges such as environmental conditions , animal availability , and the ... |
heat shock proteins ( hsps ) are considered part of a family of proteins known as stress proteins since their expression is induced by a wide range of stressors , such as oxidative stress , thermal stress , ischemia , exercise , metabolic stress , and many others .
the 72 kda member of the 70 kda family of heat sh... | recent evidence shows divergence between the concentrations of extracellular 70 kda heat shock protein [ ehsp70 ] and its intracellular concentrations [ ihsp70 ] in people with type 2 diabetes ( t2 dm ) .
a vital aspect regarding hsp70 physiology is its versatility to induce antagonistic actions , depending on the l... |
melioidosis , an infectious disease caused by the tier 1 select agent burkholderia pseudomallei , is notoriously difficult to cure 1 .
north - eastern thailand is a hot spot for this infection , with an annual incidence of 21.0 per 100 000 population and a case - fatality rate of 40% 2 . for patients who survive th... | we examined whether quantitative biofilm formation and/or lipopolysaccharide type of burkholderia pseudomallei was associated with relapsing melioidosis .
we devised a 1 : 4 nested case
control study in which both cases and controls were drawn from a cohort of patients with primary melioidosis . paired isolates f... |
chlorophyll and the associated accessory
pigments allow plants to maximise use of the visible light
spectrum for photosynthesis . by establishing internal
gradients in light capture ,
the green pigments enable plants to
respond rapidly to changes in the spectral environment , as well
as to exploit niche h... | anthocyanins , the pigments responsible for
spectacular displays of vermilion in the leaves of deciduous
trees , have long been considered an extravagant waste of a
plant 's resources .
contemporary research , in contrast , has begun
to show that the pigments can significantly influence the way a
leaf respo... |
hemostats , sealants , and adhesives are gaining increasing acceptance in surgical practice in the united states and presently represent a multi - billion dollar industry .
a set of definitions and nomenclature are helpful in order to facilitate the safest and most cost effective use of these materials.13 a hemostat ... | the purpose of this review is to clarify the present use of fibrin sealant in rhyditectomy procedures and help maximize the appropriate and safe application of this material .
a set of terms and definitions for hemostats , sealants , and adhesives based on group , category , and class will be employed to highlight th... |
the united nations children 's fund ( unicef ) plays a leading role in the collection , compilation , analysis and dissemination of data to inform sound policies , legislation , and programmes for promoting children 's rights and wellbeing , and for global monitoring of progress towards international goals and targets ... | the united nations children s fund ( unicef ) plays a leading role in the collection , compilation , analysis and dissemination of data to inform sound policies , legislation and programmes for promoting children s rights and well - being , and for global monitoring of progress towards the millennium development goals ... |
in patients with neurogenic bladders as the result of spinal cord injury or spinal disease , complications such as upper urinary tract damage , infection , stone formation , and incontinence commonly occur .
in such patients , procedures that are intended to decrease bladder pressure are required to prevent further d... | purposein patients with neurogenic bladder due to spinal cord injury or disease who undergo augmentation cystoplasty ( ac ) for not only bladder dysfunction but also sphincteric incontinence , the need for concomitant bladder neck reconstruction at the time of ac has not yet been established .
the aim of this study w... |
inflammation and altered immune processes are involved in all forms of pulmonary vascular disease underlying pulmonary hypertension , particularly , pulmonary arterial hypertension ( pah ) .
perivascular inflammatory elements have been reported in several etiologies of pah , from the idiopathic form to pah associated... | background and objective .
inflammation is central in the pathogenesis of pulmonary hypertension .
we investigated how serum cytokines correlate with clinical features , hemodynamics , and lung histology in young patients with pulmonary hypertension associated with congenital cardiac shunts .
design .
prospecti... |
breast cancer is the most frequently observed type of invasive cancer , affecting approximately 1 million women worldwide and causing bone metastases in 65% to 75% of patients .
bisphosphonates are some of the most effective treatments for preventing complications related to bone metastases . zoledronic acid ( za )
... | abstractone of the most important adverse effects of zoledronic acid ( za ) is osteonecrosis of the jaw ( onj ) . in previous literature ,
several risk factors have been identified in the development of onj . in this study
, we aimed to determine the role of trastuzumab , an antiangiogenic agent , as an independent... |
it had been studied extensively in two phase iii trials [ the apixaban versus acetylsalicylic acid to prevent stroke ( averroes ) and apixaban for the prevention of stroke in subjects with atrial fibrillation ( aristotle ) ] as potential alternatives to warfarin for stroke prevention in atrial fibrillation ( af ) patie... | atrial fibrillation ( af ) is a common cardiac arrhythmia , especially in the elderly population .
it is associated with cardioembolic complications , particularly strokes , resulting in severe functional deficit or death .
af patients are first stratified into low , intermediate , and high risk for thromboembolic ... |
the impact of heat on nerve conduction was initially described by hodgkin and katz in
19491 .
changes in sodium and potassium
channel activation are primarily responsible for heat - related nerve conduction changes1 , 2 .
with increasing temperature , voltage - gated sodium channel activation and deactivation
... | [ purpose ] physiotherapeutic heating agents are classified into two groups :
superficial - heating agents and deep - heating agents . therapeutic ultrasound is a
deep - heating agent used to treat various musculosketal disorders .
numerous studies have
attempted to determine the impact of ultrasound on healthy... |
attempted or accidental superwarfarin exposure has become an important public problem in western countries ( 1 ) , as intoxication can cause prolonged bleeding diathesis , and sometimes fatal results . over 10,000 cases of superwarfarin intoxication were reported in 2008 to the poison control centers toxic exposure sur... | this observational study aimed at evaluating recent superwarfarin intoxication of korean patients .
ten patients were diagnosed as or highly suspicious for superwarfarin intoxication .
case report forms described by attending hematologists of the patients were collected and analyzed .
bleeding symptoms were varie... |
squamous cell carcinoma ( scc ) of the buccal mucosa accounts for 23% to 37% of all intraoral cancers .
the highest incidence rate is observed in india , australia , brazil , france and south africa .
a male to female ratio is about 2:1 with the largest number of oral sccs developing in the fourth and fifth decades... | squamous cell carcinoma ( scc ) of the buccal mucosa accounts for 23% to 37% of all intraoral cancers , the prognosis is generally poor .
we reported a case of local invasion of buccal squamous cell carcinoma .
a 32-year - old man referred to the clinic with a chief complaint of swelling in the right cheek region t... |
although targeted endoscopic ultrasound - guided fine - needle aspiration ( eus - fna ) of the cyst wall following fluid aspiration has demonstrated improved overall diagnostic sensitivity for potentially malignant mucinous cysts 1 , there are reports concerning a dissemination risk from eus - fna .
the enhanced diag... | background and study aims : we report on a 75-year - old man who was admitted due to pancreatic cystic lesion accompanied by a solid mass with liver metastasis .
endoscopic ultrasound - guided fine - needle aspiration ( eus - fna ) was performed on the solid mass , and pathological findings revealed the lesion to be ... |
a single - page questionnaire ( technical appendix ) was sent to the lead cf physician in all uk pediatric and adult cf centers identified by the principal uk cf charity , the cystic fibrosis trust , in 2009 .
results were tabulated and basic statistical analysis performed by using microsoft excel 2007 ( microsoft , ... | incidence of pulmonary infection with nontuberculous mycobacteria ( ntm ) is increasing among persons with cystic fibrosis ( cf ) .
we assessed prevalence and management in cf centers in the united kingdom and found 5.0% of 3,805 adults and 3.3% of 3,317 children had recently been diagnosed with ntm .
of those , 44... |
descrever aspectos relacionados ao diagnstico e tratamento de pacientes com doena pulmonar por metal duro ( dpmd ) e realizar uma reviso da literatura .
estudo retrospectivo dos pronturios mdicos de pacientes atendidos no servio de doenas respiratrias ocupacionais do instituto do corao , localizado na cidade de so pa... | abstractobjective : to describe diagnostic and treatment aspects of hard metal lung disease ( hmld ) and to review the current literature on the topic . methods : this was a retrospective study based on the medical records of patients treated at the occupational respiratory diseases clinic of the instituto do corao , i... |
acute megakaryoblastic leukemia ( aml m7 ) is a rare hematological malignancy accounting for less than 5% of all cases of acute myeloid leukemia .
aml m7 accounts for 7 to 10% of all cases of childhood aml but less than 1% of aml cases in adults .
diagnosis is primarily based on bone marrow examination including bo... | extramedullary deposits may be the presenting feature of acute myeloid leukemia .
an early and accurate diagnosis on cytology will aid in correct patient management .
this is especially true for patients with acute megakaryoblastic leukemia ( aml m7 ) , where bone marrow aspiration may yield only a dry tap .
whil... |
rubinstein taybi syndrome ( rts ) is characterized by mental retardation , postnatal growth deficiency , microcephaly , specific facial characteristics , broad thumbs , and big toes .
a majority of patients have mutations in the gene that encodes the transcriptional coactivator , cyclic amp - responsive element - bi... | rubinstein taybi syndrome ( rts ) is a rare genetic disorder with characteristic physical anomalies .
it is characterized by mental retardation , postnatal growth deficiency , microcephaly , specific facial characteristics , broad thumbs , and big toes .
behavioral problems are common with rts ; they include menta... |
eph receptors were identified in the late 1980 's and are known as largest family of receptor tyrosine kinases .
they consist of a glycosylated extracellular domain with the immunoglobulin - like ligand - binding site , followed by a cysteine - rich region and two fibronectin type iii repeats ( figure 1 ) .
conne... | eph receptors and their ephrin ligands were identified in the late 1980 's .
subsequently , they were linked to different physiological and pathophysiological processes like embryonic development , angiogenesis , and tumorigenesis . in this
regard , recent work focused on the distribution and effects of eph recepto... |
giant anal condyloma is a rare sexually transmitted disease involving the perianal and external genital tract area in the form of a large exophytic , cauliflower - like mass .
complete surgical excision is the treatment of choice and often wide wounds are necessary to reach clear margins and prevent recurrence . vari... | introductiongiant anal condyloma also called buschke
lwenstein tumor is a rare sexually transmitted disease involving anogenital region with potential malignant degeneration into invasive squamous carcinoma .
complete surgical excision is the treatment of choice and often wide wounds are necessary to reach clear ma... |
due to a very extensive territory of yakutia ( 3,083,000 km ) , it is hardly possible to estimate permafrost temperatures at all of its 200 cattle burial grounds , especially because most grounds are situated in very remote and hard - to - reach places .
we used the data of weather stations located in the same admini... | climate warming in the arctic may increase the risk of zoonoses due to expansion of vector habitats , improved chances of vector survival during winter , and permafrost degradation .
monitoring of soil temperatures at siberian cryology control stations since 1970 showed correlations between air temperatures and the d... |
histoplasmosis , also known as darling 's disease , is a systemic fungal infection caused by the dimorphic fungus , histoplasma capsulatum .
infection is acquired by inhalation of conidia from soil contaminated by bird or bat excreta .
histoplasmosis can manifest in a bewildering array of clinical types and variati... | a case of chronic disseminated cutaneous histoplasmosis with unusual skin manifestations in an immunocompetent host is reported .
presence of cutaneous ulcers , linear erythematous plaques , skin coloured atrophic plaques and recurrent self - limiting oral ulcers in a single patient has not been documented in literat... |
indonesia shows an amazing diversity of plants species that have been associated with the human health from time immemorial .
many of them were reported to have various desirable activities ; however , only 2022% were cultivated .
research of indonesian medicinal plants using modern laboratory facilities has been s... | infrared ( ir ) spectroscopy combined with chemometrics has been developed for simple analysis of flavonoid in the medicinal plant extract .
flavonoid was extracted from medicinal plant leaves by ultrasonication and maceration .
ir spectra of selected medicinal plant extract were correlated with flavonoid content u... |
osteopontin ( opn ) is a bone associated , extracellular matrix glycosylated phosphoprotein which is produced by several cell types , including osteoblasts , osteoclasts , immune cells , endothelial cells , epithelial cells and extra - osseous cells ( skin , kidney and lung ) ( 13 ) . due to differences in post - trans... | human osteopontin ( opn ) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body . in recent years
, accumulating evidence has indicated that the aberrant expression of opn is closely associated with tumourigensis , progression and most prominently with metastasis in several tumour ty... |
malignant peripheral nerve sheath tumor ( mpnst ) accounts for about 5 - 10% of all soft tissue sarcomas .
the fact that the presence of this tumor in the buttock region is extremely rare has prompted the authors to report this case .
this is an interesting tumor not encountered very much in the neuro - oncology li... | malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation , malignant triton tumor , has a rare incidence .
we report such a case in a 40-year - old male who presented with a mass over the buttock .
he was a previously diagnosed case of neurofibroma in the same area .
histomorphology supported... |
according to the international agency for research on cancer ( iarc ) , leather tanning and processing is not classifiable as to its carcinogenicity to humans , although the production process involves exposure to numerous chemicals , for some of which there is evidence of carcinogenicity in humans .
however , in 198... | work in leather tanning involves exposure to a wide range of chemicals
. some of these are carcinogens or suspected carcinogens . increased risks for a number of cancers
have been reported among the tannery workers . in the present review ,
a detailed account of lung cancer , testicular cancer , soft tissue sarco... |
although twin and familial aggregation studies have revealed a significant genetic component involved in the etiology of stroke , not all of the genetic risk factors responsible for this heritability have been determined .
classical linkage analysis approaches have reported an association of the pde4d and alox5ap gen... | inflammation has been associated with atherothrombotic stroke and recently with cardioembolic stroke .
different genetic risk factors have been specifically associated with the subtypes of ischemic stroke ( cardioembolic , atherothrombotic , and lacunar )
. however , there are no studies that have generated genetic... |
when estimating genetic parameters , the influence of environmental effects on milk yield is generally accounted for by using previously calculated correction factors or by including these effects directly in the model .
these procedures decrease environmental variation and allow more reliable comparisons among anima... | the objectives of this study were to estimate the genetic parameters for milk yield unadjusted and adjusted for days in milk and , subsequently , to assess the influence of adjusting for days in milk on sire rank .
complete lactations from 90 or 150 days of lactation to 270 or 350 days in milk were considered in thes... |
the study of cancer in humans is impeded by several reasons , such as inaccessibility to the tumor sites , difficulty in the assessment of tumor biology , and ethical concerns .
immunodeficient mice that can not reject xenotransplanted cells have been shown to be the best living recipients for developing xenograft mo... | purposeno lung cancer xenograft model using non - obese diabetic ( nod)-scid il2rg/ mice has been reported .
the purpose of this study is to select a suitable mouse strain as a xenogenic host for testing tumorigenicity of lung cancer.materials and methodswe directly compared the susceptibility of four immunodeficient... |
controlled induced hypotension is a common procedure during anaesthesia applied to patients undergoing , among others , endoscopic sinus interventions .
decreased blood pressure allows reduction of bleeding in the surgical field , minimization of blood loss , better visibility and therefore , it increases the surgeon... | backgroundcontrolled induced hypotension guarantees less blood loss and better visibility of the surgical site .
the impact of hypotension on post - operative cognitive functions is still being discussed .
the objective of this study was to evaluate the effects of controlled induced hypotension on the cognitive fun... |
this 2 year - old hispanic male has a past medical history of hypoplastic left heart syndrome ( hlhs ) that required multiple cardiothoracic surgeries including a norwood procedure with a sano shunt after birth , a bidirectional glenn procedure at 4 months of age , and two subsequent tricuspid valve repairs .
he had ... | a 2-year - old boy with hypoplastic left heart syndrome that required multiple cardiovascular surgeries and a heterozygous prothrombin g20210a mutation with resulting thrombophilia maintained on warfarin presented with acute right middle cerebral artery ( mca ) infarction manifesting as a left hemiplegia .
an mri rev... |
multiple myeloma is a monoclonal malignant neoplasm of plasma cell origin which occurs in the bone marrow and may result in extensive destruction of skeletal structures .
it most commonly affects the skull , vertebrae , and pelvis , with pain , fatigue , swelling , and anemia being some of the most common clinical pr... | it is rare that multiple myeloma ( mm ) occurs as a primary lesion in the jaws ; we report such a case in an elderly patient involving the gingiva of the left posterior mandible .
multiple myeloma is a monoclonal malignant neoplasm of plasma cell origin which occurs in the bone marrow and may result in extensive dest... |
dental implantation and fixation of screws for any reason are performed by drilling the bone and the success of these operations depend on many factors . through these factors , thermal injuries occurring due to temperature raise during drilling ,
the threshold level for thermal injuries on the bone is the 47c for a ... | objective : osteotomies , performed by rotational instruments , can cause temperature rise on the bone and elevated temperature can disrupt the bone healing . when the osteotomies are performed for the insertion of miniscrews , the bone healing disruption may cause stability loosening or failures .
saline irrigation ... |
in 2001 , the human genome project ( hgp ) consortium and celera genomics reported the first drafts of sequences of the human genome [ 1 , 2 ] . the hgp consortium used the hierarchical sequencing or clone - by - clone approach , whereas celera genomics used the whole genome shotgun ( wgs ) approach , which had been ... | we have developed a windows - based program , conpath ,
as a scaffold analyzer .
conpath constructs scaffolds by ordering and orienting separate sequence contigs by exploiting the mate - pair information between
contig - pairs .
our algorithm builds directed graphs from link information and traverses them ... |
very recently , the journal of medicinal chemistry embraced the qhnmr concept by including absolute qhnmr as an acceptable
and established scientific method for purity analysis . as a quantitative method , qhnmr continues to
gain popularity in the biopharmaceutical industry and acceptance by
the international con... | chemical standardization , along with
morphological and dna analysis ensures the authenticity and advances the
integrity evaluation of botanical preparations .
achievement of a more
comprehensive , metabolomic standardization requires simultaneous quantitation
of multiple marker compounds . employing quantita... |
natural orifice transluminal endoscopic surgery ( notes ) has recently generated significant interest amongst surgeons and gastroenterologists .
pushing minimally invasive surgery a step forward , the concept of incisionless surgery is appealing to patients and physicians alike . accessing the abdominal cavity and it... | natural orifice transluminal endoscopic surgery ( notes ) is an evolving experimental field exploring the technical feasibility and outcome of therapeutic interventions performed through the natural orifices of the body .
the knowledge accumulating in notes is the result of animal experimentation and ongoing early cl... |
multiple randomized trials over the last four decades have established the equivalence of mastectomy and breast - conserving therapy ( bct ) in early stage breast cancer .
more recently , accelerated partial breast irradiation ( apbi ) has become an acceptable means of delivering adjuvant radiation in early stage bre... | purposeaccelerated partial breast irradiation ( apbi ) is an accepted treatment option in breast - conserving therapy for early stage breast cancer .
however , data regarding outcomes of patients treated with multi - lumen catheter systems who have existing breast implants is limited .
the purpose of this study was... |
le programme krescent ( kidney research scientist core education and national training ) a t lanc en 2005 pour augmenter la capacit de la recherche sur les maladies du rein travers le canada , et pour encourager la transmission des connaissances au sein des quatre axes de recherche en sant .
cette tude avait pour bu... | background : the kidney research scientist core education and national training ( krescent ) program was launched in 2005 to enhance kidney research capacity in canada and foster knowledge translation across the 4 themes of health research.objective:to evaluate the impact of krescent on its major objectives and on the ... |
as an international
megacity with a population of over 20 million ,
beijing has been suffering from frequent smog events in recent years .
since the official daily monitoring data became available in 1999 ,
particulate matter has been shown to be a major air pollutant in beijing , and its impact to the public h... | particulate
matter ( pm ) air pollution poses a formidable public
health threat to the city of beijing . among the various hazards of
pm pollutants , microorganisms in pm2.5 and pm10 are thought to be responsible for various allergies and for the
spread of respiratory diseases . while the physical and chemical ... |
five thoroughbred horses ( two females and three geldings ) , aged 4 to 7 years old with
body weight of 493.8 26.6 ( mean sd ) kg , belonging to the equine research institute ,
japan racing association , were assigned to the experiment .
these horses had been routinely
grazed for 2 months and specially traine... | the present study aimed to clarify changes of oxidative stress and antioxidative
functions in treadmill - exercised thoroughbred horses ( n=5 , 3 to 7 years old ) , using
recently developed techniques for measurement of serum d - roms for oxidative stress , and
bap for antioxidative markers . also , the effect of... |
hyperthyroidism ( ht ) due to thyroiditis is rarely observed in children treated for neoplastic diseases .
one of the causes of ht may be an infectious process in the thyroid gland .
fungi , most commonly candida and aspergillus species , belong to infectious factors of ht [ 13 ] .
literature gives only few repor... | thyroiditis due to fungal infection is an extremely rare cause of hyperthyroidism .
the most common etiological factor of thyroiditis is aspergillus .
infections due to members of the mucorales have been an increasing clinical problem in recent years , and the prognosis in generalized infections due to those fungi ... |
although renal embolization is reported to be a safe and effective therapeutic procedure for embolization of small branches of renal artery , it is mainly used for urological purposes , i.e. vascular malformations , angiomyolipomas , and renal tumors that are not amenable to surgical resection [ 1 , 2 ] .
a search of... | in the case reported here , after prolonged medical therapy resistance , severe proteinuria subsided following bilateral renal artery embolization ( rae ) . thereafter , respiratory distress , anasarca edema , muscle mass , and serum albumin level improved after regular hemodialysis .
although rae is reported to be a... |
in 1902 , albert moll published his comprehensive , 650-page book rztliche ethik : die
pflichten des arztes in allen beziehungen seiner thtigkeit [ medical ethics : the
doctor s duties in all relations of his work ] .
at this time , moll was already well known as a medical author : his 1889 book on hypnotism and... | in 1902 , albert moll , who at that time ran a private practice for nervous diseases in berlin , published his comprehensive book on medical ethics , rztliche ethik . based on the concept of a contractual relationship between doctor and client
, it gave more room to the self - determination of patients than the conte... |
to react appropriately to danger , both animals and humans must rapidly marshal a complex set of behavioral responses .
the locus ceruleus ( lc ) , which is located in the dorsal pons , plays a crucial role in activating central and peripheral nervous system responses to threat . through its broad connections with co... | since posttraumatic stress disorder ( ptsd ) was first recognized as a psychiatric disorder , it has generated a great deal of scientific interest .
recent studies on the neurobiology of ptsd provide evidence that ptsd is biologically distinct from other types of traumatic and nontraumatic stress responses .
this p... |
a 28-year - old unmarried male from low socioeconomic status came to the hospital for consultation of psychiatric problems along with his caregivers .
the presenting complaints were unprovoked aggressive outbursts , poor self - care , disorganized behavior and self - mutilating behaviors for last 4 years .
physical... | cavum septum pellucidum ( csp ) is a neurodevelopmental anomaly , which is commonly reported in schizophrenia patients .
various symptoms of schizophrenia , including thought disturbances have been associated with csp .
we present a rare case of undifferentiated schizophrenia with csp who presented with self - muti... |
glucagon - like peptide 1 receptor agonists ( glp1ras ) have become an accepted part of the diabetes pharmaco - therapeutic landscape .
the glp1ras are included in guidelines from various professional bodies such as the international diabetes federation ( idf ) , the american diabetes association ( ada ) , european a... | the individualized treatment of type 2 diabetes mellitus , using various glucagon - like peptide receptor agonists ( glp1ras ) , has recently been described . as experience with existing glp1ras grows , and as newer molecules in the development pipeline continue to progress , interest related to these drugs continues t... |
bony fractures are one of the most common reasons for physician visits worldwide . with greater public interest in physical fitness activities to maintain a healthy lifestyle , metatarsal stress fractures are commonly encountered by clinicians .
metatarsal stress fractures , which account for nearly 25% of all stress... | bone fractures are one of the leading causes of emergency room visits worldwide , with approximately 8 million bony fractures occurring annually in the us alone .
although the majority of fractures do not cause significant long - term morbidity and mortality , approximately 10% of these fractures result in impaired f... |
he was admitted for an elective left typanomastoidectomy and removal of the incus and malleus with tympanoplasty .
his medical history included hypertension , dyslipidemia , gout , polycystic kidney disease and gastroesophageal reflux disease .
his medications at the time of admission were rosuvastatin , domperidon... | pasteurella multocida is a gram - negative anaerobe that is known to colonize household pets ; in fact , it has been reported to be present in a majority of cats and dogs .
p multocida can cause a variety of infections in humans , of which skin infections are the most common .
this article describes a case involvin... |
the incidence of differentiated thyroid cancer ( dtc ) has increased globally over the last several decades , and iodine-131 is routinely used to treat dtc after total or near - total thyroidectomy to ablate the remnant thyroid tissue and enable physicians to detect tumor recurrence or distant metastasis more easily . ... | iodine-131 is a radioisotope that is routinely used for the treatment of differentiated thyroid cancer after total or near - total thyroidectomy .
however , there is some evidence that iodine-131 can induce liver injury . here
we report a rare case of drug - induced liver injury ( dili ) caused by iodine-131 in a p... |
the postoperative care has changed from admission in the hospital for several days to total ambulatory care .
european and north american studies have examined the safety and early recovery of patients and have justified this change [ 13 ] .
the less developed countries including india have also adopted this change... | purpose . we investigated acute endophthalmitis incidence following cataract surgery vis - a - vis the current technological and postoperative care changes in higher and lower socioeconomic categories of patients in south india .
methods . in a retrospective case control study
, we analyzed 62 cases of acute endoph... |
ageing is one of the most complex biological processes of growing older and defined as the intrinsic , inevitable , and irreversible age - related process of loss of viability and increase in vulnerability or a progressive functional decline , or a gradual deterioration of physiological function with age , including a... | ageing , also called as senescence , is one of the most complex , intrinsic , biological processes of growing older and resulting into reduced functional ability of the organism .
telomerase , environment , low calorie diets , free radicals , etc .
, are all believed to affect this ageing process .
a number of ge... |
we aim at presenting a simple way to prioritize reservoir species in relation to their capacity to carry multiple agents of potential diseases .
we illustrate this simple method with rodent - borne diseases in thailand , a country that showed major outbreaks of several rodent - borne diseases in the past years ( 1 ) ... | backgroundcomparative analysis , which aims at investigating ecological and evolutionary patterns among species , may help at targeting reservoirs of zoonotic diseases particularly in countries presenting high biodiversity . here
, we developed a simple method to target rodent reservoirs using published studies scree... |
epithelioid hemangioendothelioma ( ehe ) is a rare tumor of the vascular endothelium that is considered to be intermediate between hemangioma and angiosarcoma .
typically , the soft tissue is involved and , less frequently , the skin , bone , liver and lung are involved . in this report
, we describe a case of cuta... | epithelioid hemangioendothelioma is an intermediate - grade vascular tumor arising from the vascular endothelium , which usually arises in soft tissue , and skin involvement is extremely rare .
we report a case that presented with primary cutaneous tumor involving the whole limb and was present since birth . |
moreover , leadership is increasingly considered an important driver in terms of organisational performance , in particular in relation to the implementation of policy designed to solve the wicked issues of society . yet , despite leadership being viewed as an essential component of integrative public sector performanc... | introductionhealth and social care collaboration is currently a key feature of improvement efforts internationally . moreover , leadership is increasingly considered an important driver in terms of organisational performance , in particular in relation to the implementation of policy designed to solve the wicked issues... |
necropsies of 95 harbor seals ( p. vitulina ) collected from july to december 2002 showed a moderate - to - severe pulmonary alveolar and interstitial emphysema and alveolar edema as the predominant findings .
histologic lesions consisted of interstitial pneumonia with multinucleated syncytial cells and a moderate - ... | approximately 21,700 seals died during a morbillivirus epidemic in northwestern europe in 2002 .
phocine distemper virus 1 was isolated from seals in german waters .
the sequence of the p gene showed 97% identity with the dutch virus isolated in 1988 .
there was 100% identity with the dutch isolate from 2002 and ... |
the transient receptor potential family is widely involved in many sensory processes , with a subset of channels implicated in the reception of temperatures .
they are named thermotrp and are responsible for thermosensation ( patapoutian 2005 ) . in mammals , there are six thermotrps : two activated by cold ( trpm8 a... | transient receptor potential channels are implicated in thermosensation both in mammals and insects .
the aim of our study was to assess the effect of mammalian vanilloid receptor subtype 1 ( trpv1 ) agonist ( capsaicin ) and antagonist ( capsazepine ) on insect behavioral thermoregulation .
we tested behavioral th... |
enterococcus faecalis is the cause of 85 - 90% of enterococcal , and third cause of nosocomial infections , especially bacteremia , sepsis in children , endocarditis , urinary tract infection ( uti ) , and wound infections .
it plays a significant role in treatment of the disease , knowledge of bacterial resistance p... | background : bacteremia due to enterococcus faecalis is usually caused by strains resistant to most antibiotics .
effective management of the disease is dependent on rapid detection and characterization of the bacteria , and determination its sensitivity pattern to antimicrobial drugs .
the aim of this study was to... |
atraumatic splenic rupture ( asr ) is an uncommon pathologic condition in which bleeding from the spleen occurs for a variety of reasons [ 13 ] . while the current trend in traumatic splenic rupture is nonoperative management including transcatheter arterial embolization [ 4 , 5 ] , splenectomy is recommended in most p... | atraumatic splenic rupture ( asr ) is an uncommon pathologic condition in which bleeding from the spleen occurs for a variety of nontraumatic reasons . while the current trend in traumatic splenic rupture is nonoperative management including transcatheter arterial embolization , the current recommendation for the treat... |
they are often caused by high - energy trauma and are associated with a high mortality rate . however , such severe injuries with complex patterns are seen more commonly nowadays due to high - speed trauma caused in road traffic accidents ( rta ) on motorways . high mortality rates ( 50%77% ) have been reported for fem... | the management of multiple complicated injured patients remains a great challenge despite advancements in modern medical care .
we present a rare case of bilateral unstable pelvic fractures associated with bilateral segmental femoral shaft fractures .
we have proposed a mechanism of such complex injury pattern and ... |
many patients with non - small cell lung cancer or gastrointestinal tract cancer have pleural effusion or ascites at diagnosis . generally ,
cytological examination is the most common method to detect malignant cells in pleural fluid or ascites ; however , the technique is known to miss up to more than 50% of tumors ... | background : cd44 is a cell surface adhesion molecule which has been implicated in various biologic functions as lymphocyte homing and activation , cellular migration and extracellular matrix adhesion . over - expression of cd44v8 - 10 has been found in several cancers and is considered to be associated with tumor prog... |
recent studies demonstrate roles for regulatory noncoding rna molecules ( ncrnas ) in normal cns development and function and in the onset and progression of various neurodegenerative diseases .
ncrnas are functional rna molecules expressed specifically in the central nervous system that do not encode proteins .
th... | noncoding rnas are widely known for their various essential roles in the development of central nervous system .
it involves neurogenesis , neural stem cells generation , maintenance and maturation , neurotransmission , neural network plasticity , formation of synapses , and even brain aging and dna damage responses ... |
stress urinary incontinence ( sui ) , which is a complaint of involuntary urine leakage on effort , exertion , sneezing , or coughing , is a common functional disease in women .
understanding of the physiopathological concepts of female sui has steadily developed and the application of this improved understanding has... | purposewe investigated whether the valsalva leak point pressure ( vlpp ) is valuable for predicting postoperative outcome measurement after transobturator suburethral tape ( tvt - o ) implantation for treating stress urinary incontinence ( sui ) in women.materials and methodsa total of 204 female patients who underwent... |
they have a theoretical advantage over metal analogues in their secure initial fixation and subsequent degradation with eventual replacement by host tissues . the rigidfix anterior cruciate ligament ( acl ) cross pin ( mitek , westwood , ma , usa ) utilises polylactic ( pla ) pins to give the advantage of 360 bone - to... | we report a case of loosening of a bioabsorbable cross - pin fixation device for anterior cruciate ligament reconstruction . forty - two months following a bone tendon bone reconstruction of the anterior cruciate ligament , the patient presented with a subcutaneous collection in the medial side of the knee . at subseq... |
data were drawn from project eat ( eating and activity in teens and young adults ) , a 10-year longitudinal study of eating - related , anthropometric , and psychosocial factors among young people .
paul , minnesota assessed in early / middle adolescence [ eati ; time 1 ( t1 ) ; age 11 - 18y ] from 1998 - 1999 .
fo... | depression may be a risk factor for overweight status , but mechanisms involved in this relationship are unclear .
this study explored behavioral factors involved in the relationship between adolescent depression symptoms and adult overweight status .
a population - based cohort of female participants in project ea... |
airway remodeling , including alterations in the thickness of the basement membrane , an increase in the number of mucus producing cells , an increase in the number of blood vessels ( angiogenesis ) , and a change in the extracellular matrix ( ecm ) protein profile and hypertrophy / hyperplasia resulting in an increase... | background . persistent asthma is characterized by airway remodeling . whereas we have previously shown that neither 2-agonists nor corticosteroids inhibit extracellular matrix ( ecm ) protein release from airway smooth muscle ( asm ) cells , the effect of their combination is unknown and this forms the rationale for t... |
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