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malignant middle cerebral artery ( mca ) infarction may occur in up to 10% of patients who have acute ischemic stroke and have a mortality rate of approximately 80% . because of the limitations of medical therapies , decompressive hemicraniectomy has been proposed for patients with space - occupying hemispheric infarct... | abstractdecompressive hemicraniectomy with malignant middle cerebral artery ( mca ) infarction is effective but remains underutilized . the aim of this study was to observe the utilization of this intervention in mainland china.we included patients with malignant mca infarction who admitted in west china hospital betwe... |
portal biliopathy is defined as the development of extensive venous collateral vessels , due to obstruction of the extrahepatic portal vein , causing impediment to portal venous drainage .
it develops from morphological changes of dilatation and stenosis of intrahepatic , extrahepatic and pancreatic ducts .
it is a... | portal biliopathy is defined as abnormalities in the extra- and intrahepatic ducts and gallbladder of patients with portal hypertension .
this condition is associated with extrahepatic venous obstruction and dilatation of the venous plexus of the common bile duct , resulting in mural irregularities and compression of... |
acute interstitial pneumonia ( aip ) is an idiopathic lung disease characterized by rapidly progressive respiratory failure occurring in patients without pre - existing systemic or lung diseases with diffuse alveolar damage histologically ( 1 , 2 ) . since the term " acute interstitial pneumonia " was first introduced ... | acute interstitial pneumonia ( aip ) is a rapidly progressive condition of unknown cause that occurs in a previously healthy individual and produces the histologic findings of diffuse alveolar damage .
since the term aip was first introduced in 1986 , there have been very few case reports of aip in children . here
... |
after more than 50 years of experience penicillamine remains the most effective treatment for patients with wilson disease for which there is ample evidence [ 1 , 2 ] .
however it also has a wide variety of toxicities , most of these can be explained in terms of chemical or immunological reactions .
the present the... | penicillamine , dimethyl cysteine , thiovaline , remains the drug of choice for the treatment of patience with wilson disease .
it is also of value in the treatment of cysteinuria and rheumatoid
arthritis , it has also been suggested that it has value in the management of other rare diseases
. it also has multipl... |
however , fractures of the pelvis constitute up to 23% of admissions to level i trauma centers .
similar to adults , octogenarians have pelvic fractures that can be associated with high - energy trauma and injury to other physiological systems that may lead to an increased incidence of complications and mortality . m... | purpose .
this study examined whether octogenarians and elderly patients with pelvic fractures have a different risk of complication and mortality as compared to adults . methods .
data was gathered from the national trauma data bank from 2002 to 2006 . there were 32,660 patients 1865 , 6,408 patients 6579 , and 5,... |
it can save lives ( both mother and child ) in the event of serious complications.1 the debate about the ideal cs rate is ongoing and shows no sign of abating.19 whereas in the past the discussion revolved largely around medical issues and whether or not cs could be justified , the question of the woman s right to choo... | backgroundthis paper explores women s experience and perception of cesarean birth in burkina faso and its social and economic implications within the household.methodsfive focus groups comprising mothers or pregnant women were conducted among residents of bogodogo health district in ouagadougou to assess the perception... |
the online version of this article ( doi:10.1007/s13300 - 014 - 0080 - 0 ) contains supplementary material , which is available to authorized users .
type 2 diabetes mellitus ( t2 dm ) is a serious progressive disorder characterized by insulin resistance and relative insulin deficiency resulting in increased blood gl... | introductionthis study aimed to assess the costs and benefits of three alternative second - line treatment strategies for swedish patients with type 2 diabetes mellitus ( t2 dm ) who fail to reach glycated hemoglobin ( hba1c ) 7% with metformin treatment alone : glucagon - like peptide-1 ( glp-1 ) receptor agonists ... |
as the number of international mega - sports events was increased the athletes and spectators get together in larger numbers .
also , the business sports commerce benefiting host nations and local community has been growing ( smith et al . ,
focus toward the sports events tends to be on the top of the athletes or m... | the purpose of this study was to apply special olympics ( so ) movement and its curricula events to the social rehabilitation of the students with intellectual disabilities in korean special school .
so is the sport organization for the people with intellectual disabilities enjoyed by the athletes more than 4.4 milli... |
in cell systems , magnesium represents an abundant species as it is present in the millimolar range ( 2 ) . in line with this , it is largely utilized for electrostatic stabilization and electrophilic activation of substrates by polarization of x o ( x = p , c ) bonds .
a special case is represented by water , which... | the catalytic steps through which dna topoisomerases produce their biological effects and the interference of drug molecules with the enzyme
dna cleavage complex have been thoroughly investigated both from the biophysical and the biochemical point of view .
this provides the basic structural insight on how this fam... |
pg ( mw 10 kda ) was synthesized by anionic , ringopening , multibranching polymerization of glycidol with slow monomer addition.37 , 38 according to our previous work , 10 kda pg has better dispersity and be synthesized more easily .
alexa fluor 488 wga and hoechst 33342 cell markers were obtained from molecular... | abstractmesoporous silicabased nanoparticles are generally accepted as a potential platform for drug loading with a lot of advantages , except for their complex purification procedures and structures that are difficult to decompose . in this work ,
biocompatible hyperbranched polyglycerol is introduced to synthesize ... |
the eukaryotic genome is functionally and spatially organized . during interphase , chromosomes fold into topologically associated domains ( tads ) and divide into heterochromatin and euchromatin . also , chromosomes associate with nuclear structures and occupy distinct territories within the nucleus . within these ter... | abstractin yeast , inducible genes such as ino1 , prm1 and his4 reposition from the nucleoplasm to nuclear periphery upon activation .
this leads to a physical interaction with nuclear pore complex ( npc ) , interchromosomal clustering , and stronger transcription .
repositioning to the nuclear periphery is control... |
rhinosporidiosis is a chronic granulomatous infectious disease caused by rhinosporidum seeberi with high prevalence in parts of indian subcontinent and sri lanka .
it produces polypoidal lesions that are friable , bleed profusely during resection and have a high tendency to recur .
the common site of occurrence is ... | rhinosporidiosis is a granulomatous disease that usually affects the nasal mucosa and nasopharynx .
the disease is widely prevalent in the tropics , especially in southern india and sri lanka . in central india , rhinosporidiosis is endemic in raipur , chhattisgarh .
involvement of the tracheobronchial tree is extr... |
based on the concept of emotional stability as defined in the literature , 250 items were developed covering initially the following 6 dimensions of emotional stability :
pessimism vs. optimismanxiety vs. calmaggression vs. tolerance.dependence vs. autonomy.emotions vs. logicapathy vs. empathy
pessimism vs. optimi... | background : emotional stability remains the central theme in personality studies .
the concept of stable emotional behavior at any level is that which reflects the fruits of normal emotional development .
the study aims at development of an emotional stability scale.materials and methods : based on available liter... |
plasmids and constructs human socs-3 cdna was amplified from
a human testis cdna library ( bd biosciences ) by pcr using specific primers
( forward , 5-atggtcacccacagcaagtttccc-3 ; reverse ,
5-ttaaagcggggcatcgtactggtc-3 ) and pyrobest dna polymerase
( takara ) .
the pcr conditions were as follow : preinc... | recent studies using socs family knock - out mice have suggested that socs
proteins have multiple biological functions in addition to their role as
negative regulators of jak - stat signaling . to explore these other functions of
this family of proteins , we used yeast two - hybrid screening to find proteins
... |
analgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years , leading to significant impairment of renal function .
the observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led to the initia... | introductionanalgesic nephropathy is a disease resulting from the frequent use of combinations of analgesic medications over many years , leading to significant impairment of renal function .
the observation of a large number of cases of renal failure in patients abusing analgesic mixtures containing phenacetin led t... |
with the abundance of dna sequence information currently available , researchers are now looking to comprehensively identify and characterize the proteomic products of the genetic blueprint .
the most widespread and high - throughput methodology being used to address this goal is mass spectrometry ( ms ) . using ms t... | peptidome is a public repository that archives and freely distributes tandem mass spectrometry peptide and protein identification data generated by the scientific community .
data from all stages of a mass spectrometry experiment are captured , including original mass spectra files , experimental metadata and conclus... |
an adult male was discovered unconscious at home and a ct head demonstrated diffuse subarachnoid hemorrhage , mild ventricular hemorrhage and hydrocephalus . on subsequent ct angiogram of head , a moderately wide neck 3 mm left anterior communicating artery ( acom ) aneurysm was identified .
the patient was taken to ... | the neuroform ez stent system is a fourth generation intracranial aneurysm stent that utilizes an integrated navigation guidewire .
while designed to facilitate stent delivery , the guidewire can rarely impede proper positioning of the stent . in this technical case report , severing the guidewire from the stent deli... |
on the hypothetical dynamic s curve of biomarkers appearance for the diagnosis of alzheimer s disease ( ad ) [ 1 , 2 ] , clinical signs seem to appear late after the positivity of in vivo biomarkers reflecting the amyloid process and the tau neuronal injury .
the development of brain imaging amyloid markers , based o... | background : sophisticated and expensive biomarkers are proposed for the diagnostic of alzheimer s disease ( ad ) .
the amyloid process seems to be early in ad , and brain amyloid load affects the frontal lobe.objective:to determine if certain simple clinical signs , especially frontal - related signs , could help re... |
when trials were first developed for use in agriculture , researchers were presumably concerned about the effect of interventions on the overall size and quality of the crop rather than on the wellbeing of any individual plant.p . m. rothwell , 2005 when trials were first developed for use in agriculture , research... | present cancer treatment strategies are based on the assumption that a therapy may work ( response ) or not work ( no - response ) .
however , the existing evidence suggests that current cancer treatment modalities may also have a cancer - promoting effect in part of the patients . in this paper ,
some relevant... |
acute cholecystitis refers to a syndrome of right upper quadrant pain , fever and leukocytosis associated with gallbladder inflammation that is usually related to gallstone disease .
patients with acute cholecystitis typically complain of abdominal pain , most commonly in the right upper quadrant or epigastrium .
.... | cardiac troponins are the most sensitive and specific serum markers of myocardial cell injury , but they can also arise without apparent cardiac injury .
besides , acute cholecystitis may be associated with nonspecific st - t wave changes in electrocardiography ( ecg ) .
the signs and symptoms of gallbladder and he... |
during 20012014 , epidemiologic data on nhp related injuries and associated rabies pep treatment were prospectively collected for patients of the marseille rabies treatment centre .
demographics , place of exposure , travel characteristics , clinical data , and rabies pep were documented .
a total of 135 cases of ... | most exposures of residents of marseille to nonhuman primates occurred among unvaccinated adult travelers to southeast asia within the first 10 days of their arrival at 2 major tourist locations in thailand and 1 in indonesia .
a small proportion of travelers received rabies immunoglobulin in the country of exposure ... |
this study was conducted as part of epidemiologic surveillance activities of the ministry of public health of the central african republic .
data were obtained through the yellow fever surveillance system and approved by the ministry of health and who .
a suspected case of yellow fever was defined as an acute onset... | during january 2007july 2012 , a total of 3,220 suspected yellow fever cases were reported in the central african republic ; 55 were confirmed and 11 case - patients died .
mean delay between onset of jaundice and case confirmation was 16.6 days .
delay between disease onset and blood collection could be reduced by... |
leishmaniasis caused by the intracellular protozoan leishmania is the second most important parasitic disease after malaria , affecting humans and animals in wide areas of the americas , asia , africa and europe .
domestic dogs are considered the main reservoir of leishmania infantum , and a risk factor for anthropon... | visceral leishmaniasis ( vl ) caused by the protozoan parasite leishmania infantum , is one of the most important zoonotic diseases affecting dogs and humans in the mediterranean area .
the presence of infected dogs as the main reservoir host of l. infantum is regarded as the most significant risk for potential human... |
halogen bonding ( xb )
refers to the attractive noncovalent interaction arising between the
electron - deficient -hole of a polarized halogen atom , such
as bromine or iodine , and an electron - rich lewis base .
while xb has been well - developed in the context of solid - state crystal
engineering and in the... | the synthesis and anion binding properties
of novel halogen - bonding ( xb ) bis - iodotriazole - pyridinium - containing
acyclic and [ 2]catenane anion host systems are described .
the xb acyclic
receptor displays selectivity for acetate over halides with enhanced
anion recognition properties compared to the... |
adequate treatment planning is one of the most important factors in successful conventional implant prosthesis , requiring clear communication between the prosthetic dentist and surgeon .
it becomes more critical when the patient has unfavorable conditions such as a severely resorbed alveolar ridge .
treatment plan... | presurgical prosthetic treatment planning is critical for the success of the implant prosthesis .
inadequate treatment plan , due to insufficient discussion between prosthodontist , and surgeon , may result in poor prognosis .
a 26-year - old male patient was referred for prosthodontic treatment after implant was p... |
in the last few years , macular diseases have been studied better , thanks to the widespread use of instruments that can simultaneously combine spectral domain optical coherence tomography ( sd - oct ) and fluorescein angiography ( fa ) .
the spectralis system ( heidelberg engineering , heidelberg , germany ) uses a ... | purposeto investigate myopic choroidal neovascularization ( mcnv ) by fluorescein angiography ( fa ) , spectral - domain optical coherence tomography ( sd - oct ) , near - infrared ( nir ) reflectance , and autofluorescence ( af).methodsthis retrospective study included 65 eyes of 62 caucasian patients with a mean age ... |
bovine spongiform encephalopathy ( bse ) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue .
analysis of molecular sequence databases ( genbank and swissprot ) shows that three bacteria ( acin... | |
the menisci are critical components of a healthy knee joint and play a crucial role in load bearing , load transmission , shock absorption , as well as lubrication and nutrition of articular cartilage.12345 ahmed et al .
showed that menisci can transmit 50% to 70% tibiofemoral compressive load in extension knee and u... | background : the relationship between medial meniscus tear and posterior cruciate ligament ( pcl ) injury has not been exactly explained .
we studied to investigate the biomechanical effect of partial and complete pcl transection on different parts of medial meniscus at different flexion angles under static loading c... |
in developing countries , human immunodeficiency virus ( hiv ) infection and neonatal tetanus ( nt ) are among the leading causes of childhood morbidity and mortality .
understanding the interaction between hiv and nt is important since it may have a major implication for nt elimination program .
newborns are prote... | background .
tetanus toxoid immunisation of pregnant mother has remained the most effective strategy in eliminating neonatal tetanus .
impaired production and/or transplacental transfer of antibodies may affect the effectiveness of this strategy .
we studied the effect of maternal hiv infection on serum levels an... |
the capacity of mature mammalian skeletal muscles to repair and maintain mass is due to the presence of undifferentiated mononuclear myogenic precursor cells , that is , the satellite cells , located at the periphery of myofiber , between the sarcolemma and the surrounding basal lamina .
satellite cells remain quiesc... | satellite cells are responsible for the capacity of mature mammalian skeletal muscles to repair and maintain mass . during aging , skeletal muscle mass as well as the muscle strength and endurance progressively decrease , leading to a condition termed sarcopenia .
the causes of sarcopenia are manifold and remain to b... |
this was a prospective study at three large swiss hospitals assessing the impact of strategies to improve postprandial glucose by optimizing the combination of oral antidiabetes drugs and/or insulin according to a prespecified scheme ( 5 ) .
included patients had type 2 diabetes 6 months with a1c between 7.0 and 12.0... | objective to assess the association of 1,5-anhydroglucitol ( 1,5-ag ) with 2-h postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.research design and methods in 55 patients , we examined self - measured postprandial blood glucose values for correlations with 1,5-a... |
more than 26% of older americans have impaired glucose tolerance ( igt ) ( 1 ) , increasing their risk for developing type 2 diabetes .
a sedentary lifestyle may further increase this risk through changes in skeletal muscle morphology and insulin signaling that worsen insulin resistance .
we ( 2,3 ) and others ( 4,... | objectivetranscapillary transport of insulin is one determinant of glucose uptake by skeletal muscle ; thus , a reduction in capillary density ( cd ) may worsen insulin sensitivity .
skeletal muscle cd is lower in older adults with impaired glucose tolerance ( igt ) compared with those with normal glucose tolerance a... |
imatinib has radically changed prognosis in chronic - phase chronic myeloid leukemia ( cml ) , with 90% overall survival rate at 8 yrs , and 4070% of patients achieving a stable mmr .
even better results have been reported in terms of cytogenetic and molecular responses and the rate of progression to accelerated / b... | primary resistance to tyrosine - kinase inhibitors ( tkis ) is quite uncommon in chronic - phase chronic myeloid leukemia ( cml ) and related to still poorly understood mechanisms , as abl mutations are rarely detected in primary resistant patients .
we report the challenging case of a cml patient who was resistant t... |
there is a long history of reconstructing ocular function with biomaterials , particularly in the outer segment of the eye where various lens materials have been employed as contact and intraocular lenses .
the discovery of the possible use of biomaterials in the eye started after the discovery of windshield plexigla... | repair and reconstruction of the cornea has historically relied on synthetic materials or tissue transplantation .
however , the future holds promise for treatments using smart biomaterials and stem cells that direct tissue repair and regeneration to ultimately create new ocular structures that are indistinguishable ... |
this problem poses an enormous burden on health care systems and has lowered the quality of life of affected individuals substantially .
world health organization 's latest projections indicate that by 2015 approximately 2.3 billion adults will be overweight and 700 million will be obese .
postmenopausal ( pm ) sta... | aim : the aim of the following study is to evaluate the effect of life - style modification on postmenopausal ( pm ) overweight and obese indian women in a randomized controlled 24 week study.materials and methods : two groups were formed group i ( n = 30 ) was designated as intervention ( dietary and exercise group ) ... |
partial cholecystectomy , whether open ( 1,2 ) or laparoscopic ( 3 ) , has been described as a safe and effective operation .
it is indicated in cases of severe acute cholecystitis , gangrenous cholecystitis or necrotizing cholecystitis , where the degree of inflammation precludes safe visualization of biliary struct... | partial cholecystectomy has been documented in the literature as a safe alternative in the management of patients with acute cholecystitis when the degree of inflammation prevents a safe dissection to identify the biliary structures for complete removal of the gallbladder .
partial cholecystectomy however is not with... |
brackets used were first premolar brackets of the 022 028 roth prescription , made of five different materials .
they were divided into the following six groups which include a control group which did not have any brackets : group i : stainless steel brackets ( victory 3 m , unitek , monrovia , ca , usa ) group ii :... | objective : to quantify the adherence of streptococcus mutans and candida albicans on brackets made of stainless steel , plastic , ceramic , titanium , and gold , and to evaluate the various sites of adherence of these microorganisms with scanning electron microscopy ( sem).materials and methods : brackets made of stai... |
debate on quality and its management and improvement initially began in 1950s , which has served as an important criterion for evaluating the performance of most organizations services , including health care organizations ( hcos ) ( 13 ) .
different models and systems , such as tqm ( total quality management ) , iso... | backgroundeuropean foundation for quality management ( efqm ) model is a widely used quality management system ( qms ) worldwide , including iran .
current study aims to verify the quality assessment results of iranian national program for hospital evaluation ( inphe ) based on those of efqm.methods:this cross - sect... |
we report on the
synergy between catalytic propulsion and mesoporous
silica nanoparticles ( msnps ) for the design of janus nanomotors as
active cargo delivery systems with sizes < 100 nm ( 40 , 65 , and 90
nm ) .
the janus asymmetry of the nanomotors is given by electron beam
( e - beam ) deposition of a v... | |
one in four people in the world is affected by mental or neurological disorders at some point in their live .
about 450 million people currently suffer from such conditions , placing mental disorders among the leading causes of ill - health and disability worldwide .
according to the world health organization ( who... | we evaluated the anxiolytic and antidepressant effects of the aqueous extract of the bark of tapinanthus dodoneifolius ( tae ) ( danser ) ( 25 , 50 , and 100 mg / kg ) , using open field , elevated plus maze , and forced swimming tests .
effect of tae was compared to standard drugs diazepam ( 2 mg / kg ) and imipra... |
the anti - mili monoclonal antibody 17.8 was generated by immunizing mice with recombinant gst - mili .
other antibodies used were anti - flag ( sigma ) , anti - sdma ( sym11 ; millipore ) , anti - adma ( asym24 ; millipore ) , anti - tmg ( santa cruz biotech ) , anti--tubulin ( developmental studies hybridoma bank )... | piwi family proteins are essential for germline development and bind piwi - interacting rnas ( pirnas 1
2
3 ) .
the grandchildless gene aub of drosophila melanogaster encodes the pirna - binding protein aub that is essential for formation of primordial germ cells ( pgcs ) 4 . here
we report that mouse , xenopus... |
life depends on the ability of an organism to correctly assess its environment and respond accordingly . to illustrate , migratory animals such as birds utilize environmental cues , including temperature and sunlight , to inform them when it is time to relocate .
failure to identify and/or respond to these cues ap... | while the traditional importance of the sensory system lies in its ability to perceive external information about the world , emerging discoveries suggest that sensory perception has a greater impact on health and longevity than was previously appreciated .
these effects are conserved across species . in this mini - ... |
salmonella typhimurium , a facultative anaerobe , has been shown to accumulate at tumor sites when injected intravenously into mouse tumor models
attenuated s. typhimurium were engineered to express fas ligand ( fasl ) to deliver this toxic , antitumor cytokine to tumor sites and to thereby enhance therapeutic potent... | intravenous administration of bacteria leads to their accumulation in tumors and to sporadic tumor regression .
we therefore explored the hypothesis that salmonella typhimurium engineered to express the proapoptotic cytokine fas ligand ( fasl ) would exhibit enhanced antitumor activity .
immunocompetent mice carryi... |
cytotoxic t lymphocytes ( ctls ) play a significant role controlling viral replication in hiv and simian immunodeficiency virus ( siv ) infections as exemplified by diverse facts such as the association of gag - specific ctl activity and viremia or progression to aids [ 1 , 2 ] , the viral escape consequence of imm... | a vaccine inducing protective immunity in mucosal tissues and secretions may stop or limit hiv infection .
although cytotoxic t lymphocytes ( ctls ) are clearly associated with control of viral replication in hiv and simian immunodeficiency virus ( siv ) infections , there are examples of uncontrolled viral replicati... |
rocuronium is a non - depolarizing neuromuscular blocking agent ( ndnmba ) , employed in the clinic as an adjunct to general anesthesia , to facilitate rapid sequence tracheal intubation and to provide skeletal muscle relaxation during surgery .
resistance to the neuromuscular effects of ndnmbas has been reported fol... | rocuronium is a non - depolarizing neuromuscular blocking agent ( ndnmba ) , employed in the clinic as an adjunct to general anesthesia to facilitate tracheal intubation rapid sequence , and to provide skeletal muscle relaxation during surgery .
many cases of resistance to neuromuscular blocking agents ( nmbas ) have... |
vaporization enthalpies are used frequently in adjusting enthalpies of formation of liquids to the standard state and in evaluating environmental transport properties .
accurate thermodynamic correlations are required to enhance the reliability of such simulations . of the thermodynamic properties ,
heat of vaporiz... | the heat of vaporization of a pure substance at its normal boiling temperature is a very important property in many chemical processes . in this work
, a new empirical method was developed to predict vaporization enthalpy of pure substances .
this equation is a function of normal boiling temperature , critical temp... |
trained research assistants obtained consent and enrolled participants as part of an ongoing prospective study measuring quality of care for hospitalized general medicine patients at the university of chicago medicine and mercy hospital and medical center ( meltzer et al . ,
the university of chicago medicine and mer... | patient - centered care includes involving patients and their families in self - management of chronic diseases . identifying and addressing barriers to self - management , including those related to health literacy and vision limitations , may enhance one 's ability to self - manage .
a set of brief verbal screening... |
nonsteroidal anti - inflammatory drugs ( nsaids ) like ibuprofen are effective for the relief of pain , and their use is widespread [ 13 ] .
ibuprofen , which contains equal quantities of ( + ) ibuprofen and ( ) ibuprofen , has been used as an anti - inflammatory and analgesic agent for over 30 years .
( + ) ibup... | a high - performance liquid chromatographic ( hplc ) and a ultraviolet ( uv ) methods were developed and validated for the quantitative determination of dexibuprofen ( di ) in pharmaceutical dosage form .
hplc was carried out by reversed phase technique on a rp-18 column with a mobile phase composed of acetonitrile a... |
essential thrombocythemia ( et ) is a philadelphia chromosome ( ph)-negative myeloproliferative neoplasm ( mpn ) .
it is characterized by thrombocytosis and megakaryocytic hyperplasia of the bone marrow with jak2v617f mutation in 50 - 60% of patients .
et transforms into myelofibrosis in a minority of cases , while... | essential thrombocythemia ( et ) is a philadelphia chromosome ( ph)-negative myeloproliferative neoplasm .
it is characterized by thrombocytosis and megakaryocytic hyperplasia of the bone marrow with jak2v617f mutation .
iron - refractory iron deficiency anemia ( irida ) is an autosomal recessive disorder , which i... |
indirect restorations play an important role in clinical dentistry . whilst clinicians often spend considerable time choosing materials or type of restorations , the cementation process is often considered less important and manufacturer 's instructions modified or ignored .
luting materials are necessary to retain s... | aim . to investigate ( a ) variability in powder / liquid proportioning and ( b ) effect of variability on diametral tensile strength ( dts ) , in a zinc phosphate cement .
statistical analyses ( = 0.05 ) were by student 's t - test in the case of powder / liquid ratio and one - way anova and tukey hsd for pair - wi... |
idiopathic parkinson 's disease ( pd ) can be difficult to distinguish from atypical parkinsonian syndromes such as progressive supranuclear palsy ( psp ) and corticobasal degeneration ( cbd ) , especially in the early stages of disease .
a simple test that is easy to administer , differentiates between parkinsonian ... | objectivedifferentiating idiopathic parkinson 's disease from atypical parkinsonian syndromes is challenging , especially in the early stages .
we assessed whether the revised addenbrooke 's cognitive examination ( ace - r ) could differentiate between parkinsonian syndromes and reflect longitudinal changes in cognit... |
the formation of a tooth occurs inside a development sac known as the dental follicle or dental sac , which surrounds the papilla of the tooth and the enamel organ 1 .
damante 2 characterized the follicle as being the remnant of the tissues that participated in the odontogenesis and remained circumjacent to the crown... | the objective of this study was to determine the correlation of the radiographic and morphological features of the dental follicle of unerupted third molars with incomplete root formation .
a cross - sectional study was carried out with 56 patients ( 105 teeth ) aged 13 to 24 years .
panoramic radiography was used ... |
selecting new targets for developing antidiabetic drugs for type 2 diabetes mellitus ( t2 dm ) is best guided by considerations of established physiological chemistry of glucose homeostasis and of prevailing views about t2 dm pathophysiology because the disease genetics that could serve as another guiding principle rem... | the glucose - phosphorylating enzyme glucokinase , a promising target for developing new antidiabetic agents , was identified through the combined efforts of basic research and human biochemical genetics .
allosteric glucokinase activators ( gkas ) were discovered by high - throughput screening of a large compound li... |
the quest of humans to conquer pain by investigating the underlying cause is a challenging and ongoing process . according to the international association for the study of pain , the definition of pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage , or described i... | the myriad pain pathophysiology has intrigued and challenged humanity for centuries . in this regard ,
the traditional pain therapies such as opioids and nonsteroidal anti - inflammatory drugs have been highly successful in treating acute and chronic pain .
however , their drawback includes adverse events such as p... |
the system response to surgical trauma includes activation of the sympathetic nervous system , the endocrine
stress response , and immunological and hematological changes .various kinds of stress cause an increase in the secretion of acth from the adenohypophysis , and ( within a few minutes ) an increase in secreti... | backgroundthe aim of the study was to determine the significance of spinal anesthesia in the suppression of the metabolic , hormonal , and hemodynamic response to surgical stress in elective surgical patients compared to general anesthesia.material/methodsthe study was clinical , prospective , and controlled and it inv... |
under carbonylative conditions , neutral
rh(i)-systems modified
with weak donor ligands ( asph3 or 1,4-oxathiane ) undergo
n - cbz , n - benzoyl , or n - ts directed insertion into the proximal c c
bond of aminomethylcyclopropanes to generate rhodacyclopentanone
intermediates .
these are trapped by n - tet... | |
experiments were performed in accordance with the guiding principles for the care and use of experimental
animals in the field of physiological sciences ( physiological society of japan ) and were approved by the
committee on animal experiments of the school of veterinary medicine , yamaguchi university . in silico... | vomeronasal 1 receptors ( v1r ) are a family of receptors for intraspecies chemosignals , including pheromones ,
and are expressed in the olfactory epithelium ( oe ) and vomeronasal organ ( vo ) . even in the well - studied
rodents ,
it is unclear which members of the v1r family cause sexual polymorphisms , as th... |
breast conservation therapy ( bct ) , which involves lumpectomy followed by adjuvant radiation therapy , has now become the standard of care in women with early stage breast cancer .
however , historically , the majority of patients with early stage breast cancer have been treated with whole breast irradiation ( wbi ... | purposeaccelerated partial breast irradiation ( apbi ) using a single - lumen device is associated with better cosmetic outcomes if the spacing between the applicator and skin is > 7 mm . however , there are no reports addressing the late toxicity and clinical outcomes in patients treated with single - entry multi - lu... |
methyl - directed mismatch repair ( mmr ) is the primary pathway for correcting replication errors and errant recombination events in escherichia coli ( 18 ) making a functional mmr pathway essential for ensuring the informational integrity of the chromosome , genomic stability and an acceptable cellular mutation rate ... | uvrd is a superfamily i dna helicase with well documented roles in excision repair and methyl - directed mismatch repair ( mmr ) in addition to poorly understood roles in replication and recombination .
the mutl protein is a homodimeric dna - stimulated atpase that plays a central role in mmr in escherichia coli .
... |
anyone who has ever suffered jet lag knows firsthand that our bodies are persistent in how they keep track of time .
this timekeeping system structures the different physiological processes to work together over the course of the day in synchrony with the physical world .
the master network coordinating this timing... | the circadian system regulates the cyclical occurrence of wakefulness and sleep through a series of oscillatory networks that comprise two different theoretical processes .
the suprachiasmatic nucleus ( scn ) of the hypothalamus contains the master oscillatory network necessary for coordinating these daily rhythms , ... |
in the western cultural tradition the mind tends to be viewed as separated from the body and , in accordance with this tradition , the sciences of the mind try to understand the mind with no reference to the body . in the last few decades , however , this has changed .
the cumulative and fast advances of the sciences... | embodied theories of mind tend to be theories of the cognitive half of the mind and to ignore its emotional half while a complete theory of the mind should account for both halves .
robots are a new way of expressing theories of the mind which are less ambiguous and more capable to generate specific and non - controv... |
malaria parasite transmission remains a serious international public health problem . in sub - saharan africa ( ssa ) , anopheles gambiae s.s .
funestus are the primary vectors of malaria parasites and show highly anthropophilic tendencies [ 1 - 3 ] .
approximately 70% of the total ssa population lives in areas inf... | backgroundthis study characterized anopheles mosquito larval habitats in relation to ecological attributes about the habitat and community - level drainage potential , and investigated whether agricultural activities within or around urban households increased the probability of water body occurrence .
malindi , a ci... |
birth weight , like growth , is determined by the complex interplay of genetic and environmental factors .
however , birth weight varies within genetically similar populations [ 1 , 2 ] , suggesting that environmental factors play a significant role
. low birth weight ( lbw ) is defined as weighing less than 2500 ... | objectives . we examined association between incidence rate of low birth weight in liveborn infants and maternal sociodemographic status in tuzla canton during 19921995 war in bosnia and herzegovina . methods .
the present study covers a 22-year period ( 19882009 ) , including the war period ( 19921995 ) , and ... |
sepsis and septic multiple organ failure are leading causes of morbidity and death in critically ill patients .
alterations to the patient 's immune system , with an excessive systemic inflammatory response on one hand and paralysis of cell - mediated immunity on the other , appear to be the key elements in the patho... | multiple organ failure is the major problem in intensive care patients . the failure of the organ ' immune system ' is frequently overlooked , however . in this issue
the article by angele and faist provides an excellent review of the topic .
deactivation of monocyte and lymphocyte functions seems to play a key rol... |
a 34-year - old female presented with history of injury to the left eye while viewing bursting firecrackers during a local festival . on initial evaluation , the patient was noted to be alert and oriented , and to have an isolated injury to the left orbit with normal neurologic examination .
local examination showed ... | a 34-year - old female presented with firecracker injury with curved metallic foreign body embedded in the left orbit and protruding out through the upper eyelid .
the report highlights notable aspects in diagnosis , decision - making , and successful removal of this unusual case of retro - orbital foreign body . |
in a study in the previous issue of critical care , huang and colleagues observed that , in the critically ill , adipose - fatty acid - binding protein ( a - fabp ) concentrations were elevated and that the serum a - fabp concentrations were independently related to serum creatinine , fasting plasma glucose , total c... | sepsis due to unabated inflammation is common .
increased production of pro - inflammatory cytokines , free radicals , and eicosanoids has been detected in sepsis and other critical illnesses but could also be due to decreased synthesis and release of anti - inflammatory molecules .
increased serum adipose - fatty ... |
diabetes mellitus is a chronic disease that has become a major health and economic problem nowadays .
387 million people in the world suffer from diabetes and it is forecast that the number will be 205 million more in 2035 .
the state expenses incurred on the disease include not only medications , hospital inpatien... | background .
type 2 diabetes mellitus ( t2 dm ) is determined by genetic and environmental factors . there have been many studies on the relationship between the composition of the gastrointestinal bacterial flora , t2 dm , and obesity .
there are no data , however , on the gut microbiome structure in monogenic for... |
multiple sclerosis ( ms ) is an immune - mediated disease affecting central nervous system ( cns ) , characterized by demyelination and axonal degeneration .
the etiology of ms is still unknown , although it is believed a complex interplay between genetic and environmental factors may have a role .
although ms is c... | multiple sclerosis ( ms ) is an immune - mediated disease affecting central nervous system ( cns ) .
although ms is classically considered a white matter ( wm ) disease , the involvement of gray matter ( gm ) in the pathogenic process has been confirmed by pathology studies and mri studies .
impairment of cognitive... |
the mammalian gastrointestinal ( gi ) tract harbors a dense and diverse microbial community , which is composed primarily of bacteria but also includes fungi , archaea , and viruses ; collectively , these are referred to as the intestinal microbiota .
these microorganisms establish symbiotic relationships with their ... | the mammalian intestinal microbiota is a complex ecosystem that plays an important role in host immune responses .
recent studies have demonstrated that alterations in intestinal microbiota composition are linked to multiple inflammatory diseases in humans , including acute graft - versus - host disease ( agvhd ) .
... |
we obtained data from the edhs 2008 4 and ehis 2015 5 , both of which were conducted by elzanaty and associates with support from the united states aid of international developmentsponsored dhs7 project . the national surveys in 2008 and 2015 were crosssectional household surveys , where sampling weights were used to p... | abstractbackground & aimsin 2015 , a national egyptian health issue survey was conducted to describe the prevalence of hepatitis c virus ( hcv ) infection . in this paper
, we describe the hcv burden in 2015 , compare the results with the national survey conducted in 2008 , and discuss the implications of the new fin... |
sjgren 's syndrome ( ss ) is a chronic , progressive autoimmune disease that mainly affects exocrine glands including the salivary and lacrimal glands1 )
. functional impairment of these glands by focal lymphocyte infiltration diminishes the production of tears and saliva and produces the clinical findings of persist... | a 40-year - old korean man presented with painful swelling and tenderness of both ankle joints as well as the plantar surfaces of both feet , along with inflammatory back pain , and a purulent discharge from the urethral orifice .
the patient also complained of sicca - like symptoms including dry eyes and dry mouth .... |
nivolumab is an anti - programmed death 1 ( pd-1 ) monoclonal antibody and has been reported to be useful for treatment of cancers including malignant melanoma .
a recent case report documenting fatal nivolumab - related myasthenia gravis ( mg ) has caused concern about the risk of increased toxicity in patients with... | abstracta 79-year - old man with lymph node recurrence of malignant melanoma received nivolumab , an anti - programmed death 1 ( pd-1 ) monoclonal antibody .
he had pre - existing ocular myasthenia gravis ( mg ) and a continued small amount of corticosteroid .
grade 3 creatine phosphokinase elevation appeared after... |
a definitive diagnosis of a lymphoma is based on cytological analysis of the intraocular fluids or tissues .
we report two cases of intraocular lymphoma diagnosed by the analyses of vitreous and infusion fluid .
case 1 was a 66-year - old woman who complained of eye floaters and was found to have diffuse vitreous o... | purposeintraocular lymphomas are rare , and they have poor prognosis . thus , early diagnosis and treatment are needed .
a definitive diagnosis of a lymphoma is based on cytological analysis of the intraocular fluids or tissues .
we report two cases of intraocular lymphoma diagnosed by the analyses of vitreous and ... |
the repercussions of stroke can be devastating , given that it can suddenly and permanently impair some of the most basic functions we all take for granted , including our mobility , speech , and effective swallowing . a national campaign by the stroke association , termed
, has recently promoted the swift presentati... | symptoms of fatigue are often reported by patients in both the acute and chronic stages of recovery following a stroke .
it is commonly associated with low mood and sleep disturbances , but can arise in their absence .
however , it has also been associated with poorer long - term outcome and , as such , its aetiolo... |
gastrointestinal endoscopy has become a routine medical procedure for diagnostic and therapeutic purposes in many diseases . as the number of cases needing an endoscopic procedure has increased ,
the incidence of various complications have also increased , making their proper management more important [ 1 - 4 ] .
a... | cerebral air embolism is an extremely rare complication of endoscopic procedure and often life threatening .
we present two cases of cerebral infarction due to air embolization caused by an endoscopic intervention .
the first case occurred during esophageal balloon dilatation for the treatment of a stricture of an ... |
a 12-year - old , male neutered domestic shorthair cat was referred for investigation of suspected hyperaldosteronism due to persistent hypokalaemia , hindlimb ataxia , weakness of 1 month s duration and a left adrenal mass that was detected on abdominal ultrasound .
hyperaldosteronism and concurrent hyperprogesteron... | case summarya 12-year - old , male neutered domestic shorthair cat was referred for investigation of suspected hyperaldosteronism due to persistent hypokalaemia , hindlimb ataxia , weakness of 1 month s duration and a left adrenal mass that was detected on abdominal ultrasound .
neurological examination findings at r... |
although traditionally preeclampsia has been viewed as a condition that resolves completely with the delivery of the placenta , there is now increasing evidence that preeclampsia may constitute a condition with significant long - term health implications for both the mother and child .
in particular preeclampsia has ... | preeclampsia is increasingly being recognised as more than an isolated disease of pregnancy . in particular , preeclampsia has emerged as an independent risk factor for maternal cardiovascular disease and has recently been recognised as a risk factor for cardiovascular disease in children exposed in utero .
preeclamp... |
its hallmark features include the presence of cutaneous
granulomatous lesions noncontiguous with the gastrointestinal tract or fistulae
.
we report a very rare case of metastatic crohn 's disease
affecting the ear in a man with longstanding crohn 's disease .
we aim to
highlight the need for clinical suspic... | objective . we reported a very rare case of metastatic crohn 's disease involving the retro - auricular region .
method . a case report and a review of literature concerning metastatic crohn 's disease .
results .
metastatic crohn 's disease is an uncommon extraintestinal cutaneous manifestation of crohn 's disea... |
the pentatricopeptide repeat ( ppr ) superfamily ( 1 ) is characterized by a degenerate 35 amino acid repeat and is specific to eukaryotes although most numerous and varied in the plant kingdom ( 2 ) , with over 400 identified in arabidopsis thaliana ( 3 ) .
ppr proteins function in rna stabilization ( 46 ) , editing... | the pentatricopeptide repeat ( ppr ) protein family is a large family of rna - binding proteins that is characterized by tandem arrays of a degenerate 35-amino - acid motif which form an -solenoid structure .
ppr proteins influence the editing , splicing , translation and stability of specific rnas in mitochondria an... |
world health organization ( who ) has recommended artemisinin class of compounds as promising novel antimalarials for further clinical development .
several semisynthetic derivatives of artemisinin , the active ingredient of chinese herb qing hao ( artemisia annua ) used traditionally for treating fevers , have bee... | single dose pharmacokinetics study of 97/63 ( ind191710 , 2004 ) , a trioxane antimalarial developed by central drug research institute , lucknow , india , was studied in rats following intravenous and oral administration .
serum samples were analysed by hplc - uv assay .
separation was achieved on a rp-18 column a... |
necrotizing fasciitis ( nf ) is a rare disease of superficial fascia and subcutaneous tissue which may take a fulminating course with systemic toxicity and a high mortality rate.1 incidence of nf following obstetric operative procedures is unknown .
it often starts following trauma and , rarely , a surgical procedure... | necrotizing fasciitis , a near - fatal soft - tissue infection complicating obstetric operative wounds , is a rare entity in obstetrics .
herein , we report two cases of necrotizing fasciitis in severely undernourished and anemic women following obstetric operative procedures . both undernourishment and anemia compou... |
according to the current guidelines of the european society of cardiology ( esc ) for patients with acute myocardial infarction with persistent st - segment elevation , intravenous anticoagulation is recommended in all patients undergoing primary percutaneous coronary intervention ( pci ) .
unfractionated heparin ( u... | aimsin the horizons trial , in - hospital treatment with bivalirudin reduced bleeding and mortality in primary percutaneous coronary intervention ( pci ) compared with heparin and routine glycoprotein iib / iiia inhibitors ( gpi ) .
it is unknown whether this advantage of bivalirudin is observed in comparison with he... |
. however , focal abnormalities on electroencephalography ( eeg ) have also been observed in patients with generalized epilepsy . in such cases
, it is supposed that the cortical focus drives widespread epileptic networks that results in generalized seizures .
, we describe a patient who had eyelid myoclonia with a... | eyelid myoclonia with absences is classified as a unique type of generalized seizure .
its pathogenesis is proposed to involve the functional abnormalities in cortical subcortical networks . here
, we describe the case of a 7-year - old boy who had eyelid myoclonia with absences , along with focal motor seizures .... |
lantibiotics are
a family of antibacterial peptide natural products
characterized by the post - translational installation of the thioether - containing
amino acids lanthionine and methyllanthionine . until recently , only
a single naturally occurring stereochemical configuration for
each
of these cross - l... | |
primary dysmenorrhea is a gynecological condition characterized by severe uterinepain during menstruation with a prevalence rateranging between 25% and 90% , inthe absence ofpelvicpathology .
it is very common during the teenage years after the menarche and less often in women after the age of 20 - 25 years .
the m... | objective : primary dysmenorrhea is defined as painful cramps during menstruation with no pelvic pathology . due to the adverse effects of non - steroidal anti - inflammatory drugs ( nsaids ) are considered as the most common pharmacological treatment for this disorder .
the present study was conducted to assess the ... |
the double duct sign is a simultaneous dilatation of both the pancreatic duct ( pd ) and the common bile duct ( cbd ) and is usually a result of narrowing of terminal parts of both the ducts due to various causes including encasement of the cbd and main pd by a pancreatic head tumour , ampullary carcinoma , pancreatiti... | double duct sign where there is a simultaneous dilatation of both the common bile duct ( cbd ) and pancreatic duct is usually associated with sinister causes like malignancies of pancreatic head or ampulla .
occasionally , benign causes like chronic pancreatitis or sphincter of oddi dysfunction ( sod ) may cause doub... |
abdomen is the third most commonly injured region of the body , involving 20% of all injured civilians who undergo surgical intervention . penetrating wounds represent 25% of all urban traumas which include gunshot , shotgun and stab wounds .
these injuries are potentially life threatening and often warrant explorati... | penetrating abdominal injuries are potentially life threatening due to the associated hemorrhagic shock and visceral injury . through and through penetrating injury with polytrauma is rarely encountered .
we report a case presenting with in situ projecting heavy metallic rod in a through and through penetrating abdom... |
drinking water quality is a worldwide concern and has the greatest impact on human health ( 1 ) .
consumption of contaminated drinking water was associated with 80 percent of disease and one third of death in developing countries ( 2 ) .
therefore , an essential basic requirement for health protection is to provide... | abstractbackgrounddrinking water quality can be deteriorated by microbial and toxic chemicals during transport , storage and handling before using by the consumer .
this study was conducted to evaluate the microbial and physicochemical quality of drinking water from bottled water coolers.methodsa total of 64 water sa... |
lung cancer remains a deadly disease with an unsatisfactory overall survival [ 1 , 2 ] .
though the treatment of patients with lung cancer includes surgery , chemotherapy and radiotherapy , the overall survival remains poor .
moreover , due to the resistance to conventional therapy , the 5-year combined survival ra... | objectives : lung cancer remains a deadly disease with unsatisfactory overall survival .
cisplatin , a standard platinum ( pt)-based chemotherapeutic agent , has the potential to inhibit the growth of lung cancer .
its use , however , is occasionally limited by severe organ toxicity . however , until now , no syste... |
worldwide ovarian cancer is the second leading cause of gynecologic cancer - related deaths behind cervical cancer .
approximately 240,000 new cases of ovarian cancer are diagnosed annually , accounting for about 4% of female cancers , and about 152,000 women die as a result of this disease . the majority of newly di... | ovarian cancer is the eighth most frequent cancer in women and is the most lethal gynecologic malignancy worldwide .
the majority of ovarian cancer patients are newly diagnosed presenting with advanced - stage disease .
primary cytoreductive surgery and adjuvant taxane- and platinum - based combination chemotherapy... |
in europe the concepts of functioning / disability and autonomy / dependency deserve special interest from the point of view of medical ontology . while functioning / disability are concepts defined at the who international classification of functioning ( icf ) , the autonomy / dependency pair is not even mentioned a... | introductionin europe the concepts of functioning / disability and autonomy / dependency deserve special interest from the point of view of medical ontology . while functioning / disability are concepts defined at the who international classification of functioning ( icf ) , the autonomy /
dependency pair is not ev... |
the liver has a remarkable capacity to regenerate in response to injury ; however , in severe cases its regenerative capacity may prove to be insufficient , and the liver injury may progress to end - stage liver disease ( esld ) and subsequent liver failure . up to two million people suffer from chronic liver disease i... | chronic liver disease ( cld ) is increasing worldwide yet there has been no major advance in effective therapies for almost five decades .
there is mounting evidence that adult haematopoietic stem cells ( hsc ) are capable of differentiating into many types of tissue , including skeletal and cardiac muscle , neuronal... |
interaction between hosts and parasites is a complex relationship that can favour one or the other depending on a number of factors .
initially , the parasite attempts to establish itself in the host while the latter resists the infection via its defense mechanisms .
consequently , host susceptibility and resistanc... | host - parasite interactions are complex , compounded by factors that are capable of shifting the balance in either direction
. the host 's age , behaviour , immunological status , and environmental change can affect the association that is beneficial to the host whereas evasion of the host 's immune response favours... |
tumors require nutrients and oxygen to grow , and new blood vessels , formed by angiogenesis , provide these substrates .
its expression is regulated by a plethora of intrinsic and extrinsic factors , with hypoxia and hypoglycemia being the major stimuli .
little is known about the exact trigger mechanisms of vegf ... | tumor angiogenesis has been identified to play a critical role in tumor growth and tumor progression , and is regulated by a balance of angiogenic and antiangiogenic cytokines .
this has been documented for solid tumors , and there is emerging evidence suggesting that tumor progression of hematological malignancies a... |
advanced glycation end products ( ages ) are modifications of proteins , lipids or nucleic acids that become non - enzymatically glycated and oxidized after contact with reducing sugars .
this process may contribute to the pathogenesis of micro- and macrovascular disease . in diabetes ,
accumulation of ages in skin... | accumulation of advanced glycation end products ( ages ) is enhanced by chronic hyperglycemia and oxidative stress and this process may contribute to the pathogenesis of vascular disease .
skin autofluorescence ( af ) , a measure of accumulation of ages in skin collagen , is associated with vascular disease in patien... |
malaria continues to be a major public health problem throughout the world despite more than a century of study , especially in africa where 90% of the global cases are recorded .
the situation is worsening due to the spread of drug resistant parasites strains , spread of insecticide resistance in the vector populati... | malaria transmission pattern was studied in 3 villages ( toubanding , daga ndoup , and keur samba guye )
situated within an area selected for clinical trials .
the study was conducted in the rainy season from july to december 2011 .
the main objective of this work was to gather baseline data on malaria transmissi... |
gastrocnemius muscle is commonly used as a local flap for coverage of soft tissue defect in the upper third of the leg .
the arc of muscle flap extends from the lower thigh , entire knee joint , popliteal fossa and upper third tibia .
gastrocnemius muscle is a workhorse flap to cover upper third tibial defects beca... | introduction : gastrocnemius muscle is a workhorse flap to cover upper third tibial defects but has a limitation in covering middle one - third tibial defects
. the inferiorly based hemi gastrocnemius muscle flap can be useful for reconstruction of the middle third of the leg .
the arterial communication between th... |
preparation of tetrapod - shaped alpha tricalcium phosphate granules ( tb ) :
the procedure used in the preparation of the tb was previously described , and the materials ( tetrabones ) were
obtained from next21 , k.k .
( tokyo , japan ) . preparation of bfgf - binding ion complex gel matrix ( f - ic gel ) : the ... | abstractthe effect of tetrapod - shaped
alpha tricalcium phosphate granules ( tetrabones [ tb ] ) in combination with
basic fibroblast growth factor ( bfgf)-binding ion complex gel ( f - ic gel ) on bone defect
repair was examined .
bilateral segmental defects 20-mm long were created in the radius of
5 dogs ,... |
a male infant ( 3 kg , primi - gravida ) , was delivered vaginally without complications following a normal pregnancy .
the ultrasound scan at 35 weeks of gestation showed an irregular volume of liquid anechoic space in the midline of the brain .
a computerized tomography ( ct ) scan of the infant 's head conducted... | a 12-week - old baby with a vein of galen aneurysmal malformation ( vgam ) was successfully treated with performing transarterial microcatheter - directed embolization with berenstein liquid coils and n - butyl cyanoacrylate in the feeding arteries .
post - procedure angiography showed a marked decrease of the blood ... |
it is clear that weight gain is a ubiquitous side effect of antipsychotic drugs ( apds ; allison et al . , 1999 ) and that apds are also associated with an increased risk of complications related to obesity , including insulin resistance , hyperlipidemia , type 2 diabetes mellitus , and cardiovascular disease ( lieberm... | although offering many benefits for several psychiatric disorders , antipsychotic drugs ( apds ) as a class have a major liability in their tendency to promote adiposity , obesity , and metabolic dysregulation in an already metabolically vulnerable population .
the past decade has witnessed substantial research aimed... |
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