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a lump in the salivary gland region often presents as a diagnostic challenge with regards to its site of origin , benign or malignant .
most of these occur in the parotid glands ; small percentages occur in the submandibular , sublingual , and minor salivary glands .
are a histologically diverse group . tumors of t... | objective .
histopathology of parotid gland tumors is extremely varied and complex due to heterogeneous cellular composition .
preoperative diagnostic tools include fine needle aspiration cytology , the role of which remains controversial .
the aim of this paper is to evaluate the usefulness and accuracy of fine ... |
variceal bleeding is the most common lethal complication of cirrhosis , with a mortality rate of 20% .
gastroesophageal varices ( govs ) are present in 50% of cirrhotics , and approximately 25% of patients with portal hypertension have gastric varices .
gastric varices are commonly classified as govs ( gastric vari... | gastric variceal bleeding is a common problem in patients with cirrhosis and is associated with increased morbidity and mortality .
management is complex and includes pharmacotherapy , endoscopic therapy , and shunt placement .
recent studies indicate that endoscopic therapy with tissue adhesives has similar hemost... |
health economics is a branch of economics that studies and evaluates the quantity , quality , and value of the limited resources available to healthcare systems , as well as determining how these factors best combine to produce certain services , with the aim of maximizing effectiveness and efficiency .
us health cos... | background : health costs have risen everywhere , worldwide , and nurses play a pivotal role in cost savings and in contributing to the financial stability of hospitals.aim:this study evaluated the awareness and performance of iranian nursing staff , with regard to health economics.materials and methods : a total of 17... |
the construction of long dna oligonucleotides , such as synthetic genes , is useful for a number of reasons . for protein expression , it is possible to improve the yield of a desired protein by optimizing codon usage to reflect the relative codon abundance in the host organism used for protein production .
long olig... | we describe a computer program , assembly pcr oligo maker , created to automate the design of oligodeoxynucleotides for the pcr - based construction of long dna molecules .
this program is freely available at and has been specifically designed to aid in the construction of dna molecules that are to be used for the ... |
pilonidal sinus is a well recognized chronic inflammatory condition which affects the natal cleft , finger web space , and it is rare in the penis
. we report on a case of penile pilonidal sinus in a 24-year - old man who has severe mental illness , autism , and developmental delay .
the literature was reviewed and... | pilonidal sinus is a well recognised chronic inflammatory condition which commonly affects the natal cleft and finger web space .
pilonidal sinus of the penis is a rare clinical entity ; few cases have been reported previously .
the treatment strategy is almost the same as treating any pilonidal sinus and involves ... |
three different types of aiha can be studied based on the behavior of the autoantibodies involved in the pathogenesis:1 ( 1 ) warm aiha , which is most commonly mediated through igg autoantiobodies ( polygenic ; commonly against the antigens of rh system ) that are most potent at temperatures 37 c , ( 2 ) cold aiha , ... | polygenic igg autoantibodies are implicated in majority of the cases of warm autoimmune hemolytic anemia ( waiha ) . in some of these cases ,
complement ( c3 ) proteins accompany the igg antibodies .
waiha mediated by c3 alone is relatively rare .
we present an interesting case of waiha with a direct antiglobulin... |
participants came from the twins early development study ( teds ) , a population - based longitudinal study of all twins born in england and wales from 1994 to 1996 .
the present paper is based on data collected from parents when the twins were approximately 8 ( mean sd = 7.89 0.53 ) , 9 ( 9.01 0.29 ) , and 12 ... | objectivedisorders on the autism spectrum , as well as autistic traits in the general population , have been found to be both highly stable across age and highly heritable at individual ages .
however , little is known about the overlap in genetic and environmental influences on autistic traits across age and the co... |
tum or consisted of a firm , well - circumscribed , ovoid piece of soft pink tissue measuring 21.51 cm in the supraglottic area of the larynx .
histologically , the mass showed a fibrous and chondromyxoid stroma containing epithelial and myoepithelial cells .
epithelial component consisted of relatively uniform - a... | pleomorphic adenoma ( pa ) is the most common benign neoplasm of the salivary glands .
it usually occurs in major salivary glands , such as the parotid and submandibular glands .
occasionally , however , it occurs in the larynx .
these lesions generally present as a slow - growing , painless mass .
malignant tr... |
secondary hyperparathyroidism ( shpt ) is often underdiagnosed or insufficiently treated in patients not yet receiving dialysis , when therapy would have greater short- and long - term benefits .
hyperparathyroidism also frequently persists after successful renal transplantation and is present in up to 50% of patie... | cinacalcet has proven effective in the treatment of secondary hyperparathyroidism ( shpt ) in dialysis patients , and it may also have benefits in stage 3 and 4 chronic kidney disease ( ckd ) .
the efficacy of cinacalcet in the treatment of shpt was investigated in a study of 54 patients with stage 3 and 4 ckd not re... |
p. vivax is the most prevalent cause of human malaria in the americas , accounting for more than 70% of total cases reported .
chloroquine ( cq ) at a dose of 25 mg / kg over three days remains the first line therapy for vivax malaria . to prevent relapse ,
pq is given to all nonpregnant patients greater than 6 mo... | the widespread use of primaquine ( pq ) and chloroquine ( cq ) , together , may be responsible for the relatively few , isolated cases of chloroquine - resistant p. vivax ( cqrpv ) that have been reported from south america .
we report here a case of p. vivax from the amazon basin of peru that recurred against normal... |
vibrio parahaemolyticus and vibrio vulnificus are important foodborne pathogens associated with the consumption of fish and shellfish , especially oysters , which have long been known to bioconcentrate vibrios within their edible tissues [ 1 , 2 ] .
vibrio vulnificus also causes life - threatening illness from wound ... | bacteriovorax were quantified in us atlantic , gulf , and pacific seawater to determine baseline levels of these predatory bacteria and possible seasonal fluctuations in levels .
surface seawater was analyzed monthly for 1 year from kailua - kona , hawaii ; the gulf coast of alabama ; and four sites along the delawar... |
the millennium cohort is the largest prospective study using primary data collection ever undertaken by the department of defense ( dod ) .
the study began in 2001 with the objective to collect and evaluate data on health , behavioral risk factors , and occupational characteristics related to military service that ma... | objectiveresearch has suggested that a higher risk of type 2 diabetes associated with sleep characteristics exists .
however , studies have not thoroughly assessed the potential confounding effects of mental health conditions associated with alterations in sleep.research design and methodswe prospectively assessed th... |
pathologically , ad is characterized by extracellular aggregation of amyloid - beta into senile plaques and hyper - phosphorylated tau protein accumulation in intraneuronal neurofibrillary tangles ( beach et al . ,
clinically , ad is characterized by progressive cognitive decline that typically presents with memory l... | backgroundalzheimer 's disease ( ad ) is a progressive neurodegenerative disorder .
current avenues of ad research focus on pre - symptomatic biomarkers that will assist with early diagnosis of ad .
the majority of magnetic resonance imaging ( mri ) based biomarker research to date has focused on neuronal loss in g... |
herbal ingredients are commonly found in many products , including cosmetics , drugs , foods , and oral hygiene products , such as mouth rinse , toothpaste , and lozenges .
for example , the biological properties of herbal substances should be evaluated to exclude the possibility of adverse effects on human tissue . ... | objectives : the aim of this study was to compare the results of dimethylthiazol diphenyltetrazolium bromide ( mtt ) and neutral red uptake ( nru ) assays of clinacanthus nutans cytotoxicity.materials and methods : mouse fibroblast ( l929 ) cells were exposed to 0.01% , 0.1% , 0.25% , and 0.5% ( w / v ) c. nutans in a ... |
cystoid macular edema ( cme ) following cataract surgery , also known as irvine - gass syndrome , is an important differential diagnosis of painless decrease in vision following uneventful cataract extraction .
the pathogenesis is likely multifactorial , ultimately leading to the breakdown of the blood - retinal barr... | purposeto report a case of acute bilateral irvine - gass syndrome.methodsthis is an observational case report.resultsan 82-year - old man with no significant ocular history developed postsurgical pseudophakic cystoid macular edema ( cme ; irvine - gass syndrome ) on consecutive phacoemulsification cataract surgeries . ... |
a pigment is a coloured organic or inorganic solid that is usually insoluble in its application media .
pigments are used when extreme resistance to light , weather or temperature is needed , e.g. in automotive paints and other outdoor applications . due to its insolubility
, a pigment will usually retain its cryst... | the structures of the , and polymorphs of quinacridone were predicted using polymorph predictor software in combination with x - ray powder diffraction patterns of limited quality .
the present work demonstrates a method to obtain crystal structures of industrially important pigments when only a low - quality powd... |
nowadays , post - operative nausea and vomiting ( ponv ) sound to be the leading cause of morbidity and discomfort among pediatric surgical patients .
ponv may at least direct patients to have longer stay at hospital after surgery but some more serious consequences such as bleeding , wound dehiscence , dehydration , ... | objectiveclonidine is an 2-agonist which is used as a sedative premedication in children .
there are conflicting results in the published literature about the effect of clonidine on the incidence of post operative nausea and vomiting ( ponv ) .
we therefore decided to evaluate the effect of oral clonidine given pre... |
the ecology of tularemia is represented by a literature that reflects the diversity of this complex zoonosis . like the literature of many other infections ,
the sheer volume of observations makes it difficult to organize and synthesize sets of working hypotheses for how the causative agent exists in nature .
an or... | the epidemiology of tularemia has influenced , perhaps incorrectly skewed , our views on the ecology of the agent of tularemia .
in particular , the central role of lagomorphs needs to be reexamined .
diverse observations , some incidental , and some that are more generally reproducible , have not been synthesized ... |
assessment of left ventricular ( lv ) function is the most common and clinically relevant task in the congenital echocardiography laboratory .
historically , those measurements have been estimated using m - mode ( mm ) and two - dimensional ( 2d ) echocardiography , with several limitations .
strain echocardiograph... | aims : three - dimensional speckle - tracking echocardiography ( 3d - ste ) is a promising new technique to evaluate left ventricular ( lv ) mechanics . the feasibility and normal values of lv strain using 3d - ste
have recently been established in adults and children .
unfortunately , no data are available in neon... |
a. pereda , c. perfumo , and d. r. perez contributed to the concept and design of the study ; a. rimondi , m. angel , j. ye , t. sutton , m. dibrbora , v. olivera , and m. i. craig analyzed and interpreted the virological and molecular data ; j. cappuccio , m. quiroga , and m. machuca performed necropsies , analyzed , ... | please cite this paper as : pereda et al .
( 2011 ) evidence of reassortment of pandemic h1n1 influenza virus in swine in argentina : are we facing the expansion of potential epicenters of influenza emergence ?
influenza and other respiratory viruses 5(6 ) , 409412.in this report , we describe the occurrence of tw... |
the older population is increasing in sweden,1 as it is in the rest of europe.2 elderly people are and will be affected by multiple chronic conditions that is , multimorbidity3 and several mental disorders,4 even when dementia disorders are not taken into account.5 multimorbidity is associated with mental health prob... | introductionelderly people with multiple chronic conditions , or multimorbidity , are at risk of developing poor mental health .
these seniors often remain in their homes with support from home care assistants ( hcas ) .
mental health promotion by hcas needs to be studied further because they may be among the first... |
since earliest times , food and nutrition have always remained one of the darkest areas and the world has failed to tackle the situation completely .
the 1996 world food summit brought back to center stage the issue of hunger and food insecurity as both cause and effect of poverty and slow growth . in the wake of thi... | introduction : nutrient adequacy is the level of intake of an essential nutrient in relation to the nutrient requirement for adequate health , which is expressed as the percentage of recommended dietary allowance . to develop an effective nationwide preventive program to combat malnutrition ,
it is necessary not only... |
using exome sequencing and a variant prioritisation strategy that focuses on loss - of - function variants , we identified biallelic , loss - of - function cep57 mutations as a cause of constitutional mosaic aneuploidies
. cep57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules .
o... | |
the protocol was approved by the institutional review boards for human studies of baylor college of medicine , the harris county hospital district , and the university of washington .
all kpd patients were identified by acute presentation with an episode of dka , defined by the presence of all of the following : anio... | objectiveketosis - prone diabetes ( kpd ) is characterized by diabetic ketoacidosis ( dka ) in patients lacking typical features of type 1 diabetes .
a validated classification scheme for kpd includes two autoantibody - negative ( a ) phenotypic forms : a
( lean , early onset , lacking -cell functional reserve )... |
lung cancer is the leading cause of cancer - related deaths in the united states . even after 30 years of
improved therapeutic approaches , the 5-year mortality of lung cancer remains alarmingly high at 86%.1 the emerging application of pharmacogenomics offers the potential to identify drugs and drug combinations in ... | introductionperformance status ( ps ) is the only known clinical predictor of outcome in patients with advanced non - small - cell lung cancer ( nsclc ) , although pharmacogenomic markers may also correlate with outcome .
the aim of our study was to correlate clinical and pharmacogenomic measures with overall surviva... |
indeed , patients with dementia often have neuropsychiatric symptoms collectively termed behavioral and psychological symptoms of dementia
( bpsd).1 depression is quite common in elderly patients with dementia.2,3 aggressive behaviors that cause great difficulties in the social functioning of patients are also commo... | patients with dementia often have neuropsychiatric symptoms .
the objective of this study was to evaluate the relationship between neuropsychiatric symptoms and progressive cognitive decline by assessing cognitive impairment , depressive symptoms , and aggressive behavior in a sample of elderly subjects .
the study... |
during july 2011april 2014 , a total of 45 blood samples were collected in edta - containing collection tubes from wild japanese macaques in aomori ( n = 25 ) , yamagata ( n = 5 ) , and wakayama ( n = 15 ) prefectures in japan .
the animals were captured by licensed trappers , in accordance with the wildlife protecti... | bartonella quintana bacteremia was detected in 6 ( 13.3% ) of 45 wild - caught japanese macaques ( macaca fuscata ) .
multilocus sequence typing of the isolates revealed that japanese macaques were infected with a new and specific b. quintana sequence type .
free - ranging japanese macaques thus represent another n... |
as described in detail below , we first estimated the exposure - response relationship between observed daily mortality and temperature data in manhattan .
we then obtained downscaled future temperature projections from sixteen climate models and two greenhouse gas emissions scenarios for manhattan .
these two inpu... | global average temperatures have been rising for the past half - century , and the warming trend has accelerated in recent decades1 .
further warming is expected over the next few decades , with significant regional variations .
these warming trends will likely result in more frequent , intense and persistent perio... |
polyamines ( pas ) are small positively charged aliphatic molecules ubiquitous in almost all life forms . in plants , spermine ( spm ) , spermidine ( spd ) , and their precursor putrescine ( put ) are the major pas present in cells at micromolar - to - millimolar concentrations .
pas have been implicated in a wide ra... | floating ferns of the genus azolla detach their roots under stress conditions , a unique adaptive response termed rapid root abscission .
we found that azolla pinnata plants exhibited dose - dependent rapid root abscission in response to the polyamines spermidine and spermine after a substantial time lag ( > 20 min ... |
they include low dietary intake , conditions associated with decreased absorption or increased urinary phosphate excretion , and conditions associated with shifts in phosphate from the extracellular to intracellular fluid .
the latter include various cellular uptake syndromes , in which hypophosphatemia develops as a... | the effect of the eshap ( etoposide , methylprednisolone , cytarabine , cisplatin ) salvage protocol on serum electrolytes has been previously reported by individual observational studies .
the most commonly described electrolyte affected by the eshap protocol is magnesium .
in addition , hypophosphatemia has been ... |
osteoporosis is a metabolic bone disease characterized by loss of bone mass and disruption of bone microarchitecture , and consequently increases the risk of fracture3,5,11,14 ) .
it is well known that estrogen plays a fundamental role in skeletal growth and bone homeostasis1 - 3,6 ) .
this is of particular importa... | objectivethe purpose of this study was to verify the appropriateness of ovariectomized rats as the osteoporosis animal model.methodstwelve female sprague - dawley rats underwent a sham operation ( the sham group ) or bilateral ovariectomy [ the ovariectomy ( ovx ) group ] .
eight weeks after operations , serum bioche... |
dacron arterial grafts are widely used in thoracic aortic replacement , but few cases of non - anastomotic aneurysmal dilatation or rupture have been reported . in most cases that have been reported , knitted , rather than woven ,
we report the clinically successful result of thoracic endovascular repair ( tevar ) of... | the intrinsic structural failure of a dacron graft resulting from the loss of structural integrity of the graft fabric can cause late graft complications .
late non - anastomotic rupture has traditionally been treated surgically via open thoracotomy .
we report a case of the successful use of thoracic endovascular ... |
it was not until the year 1900 , when karl landsteiner at the university of vienna , discovered why some blood transfusions were successful while others could be deadly .
landsteiner discovered the abo blood group system by mixing the red cells and serum of each of his staff .
he demonstrated that the serum of some... | the evolution of human blood groups , without doubt , has a history as old as man himself .
there are at least three hypotheses about the emergence and mutation of human blood groups .
global distribution pattern of blood groups depends on various environmental factors , such as disease , climate , altitude , humid... |
homogeneous gold catalysis
is a relatively new field of research
that became popular in the early years of this century .
although there
were a few scattered papers describing reactions of aromatic compounds
with gold salts , the first signals of the synthetic potential of gold
in homogeneous catalysis came... | cycloisomerizations
of 1,n - enynes catalyzed by
gold(i ) proceed via electrophilic species with a highly distorted
cyclopropyl gold(i ) carbene - like structure , which can react with different
nucleophiles to form a wide variety of products by attack at the cyclopropane
or the carbene carbons . particularly... |
we
describe here a method that can rapidly and accurately compute
the potentials of mean force ( pmfs ) between spherical univalent ions
in water .
the pmf between an ion a and ion b represents the reversible
work ( as a function of distance between the two ions , r ) , averaged over all the configurations of... | we
perform extensive molecular dynamics ( md ) simulations between
pairs of ions of various diameters ( 25.5 in increments
of 0.5 ) and charge ( + 1 or 1 ) interacting in explicit
water ( tip3p ) under ambient conditions .
we extract their potentials
of mean force ( pmfs ) .
we develop an interpolation ... |
the approval of five new treatments for metastatic castrate - resistant prostate cancer ( mcrpc ) within the last 5 years has been an unprecedented milestone in prostate cancer treatment [ figure 1 ] . not only have these drugs successfully changed the therapeutic landscape for this disease but at the same time
these... | introduction : prostate cancer remains a challenge as a target for immunological approaches . the approval of the first cell - based immune therapy , sipuleucel - t for prostate cancer introduced prostate cancer as a solid tumor with the potential to be influenced by the immune system.methods:we reviewed articles on im... |
nppe is an uncommon complication of extubation in the early post - operative period and most commonly caused by laryngospasm .
acute laryngeal spasm results in airway obstruction and can cause life threatening pulmonary edema due to negative intra thoracic pressure .
the incidence of nppe has been reported to be 0.... | negative pressure pulmonary edema ( nppe ) is defined as fluid transudation into the pulmonary interstitium which occurs as a result of elevated negative intrathoracic pressure caused by the upper respiratory tract obstruction and strong inspiratory effort .
nppe is usually seen during emergence from general anesthes... |
tufted angioma is a rare vascular neoplasm clinically characterized by slowly progressive pink to red macules or plaques on the neck , trunk , or shoulders of children or young adults .
these tumors follow a benign course of angiomatous proliferation , without any evidence of malignancy .
we report herein a case of... | tufted angioma ( ta ) is a localized benign hamartomatous vascular proliferation usually presenting in the childhood as an erythematous plaque .
we report here a rare case of multifocal ta in an 8-year - old boy who presented which two large annular lesions as well as multiple papules and nodules on the back for the ... |
upper gastrointestinal bleeding is one of the most common emergencies managed by gastroenterologists that results in high patient morbidity and medical care costs ( 1 ) .
the main sources of upper gastrointestinal bleeding are peptic ulcers , esophagitis , drug - induced mucosal damage , sequelae of portal hypertensi... | aimthe purpose of the present study was to evaluate the number and proportion of various causes of upper gastrointestinal bleeding and actual numbers of non - nsaid , non - helicobacter pylori ( h.pylori ) peptic ulcers seen in endoscopy of these patients.backgroundthe number and the proportion of patients with non- h.... |
basal cell carcinoma ( bcc ) is the most common type of skin cancer in the head and neck region .
the incidence of bcc is on the rise , and it represents approximately 65% of all skin carcinomas [ 13 ] .
bcc is not usually life threatening , unlike malignant melanoma , but it is locally invasive and may lead to con... | the aim of the study is to analyze all completely excised bccs in the head and neck region with regard to age , sex , personal and familial history , skin type , tumor localization and size , histopathological subtype of tumor , reconstruction method , and recurrence rates .
incompletely excised bccs were not include... |
myocardial infarction ( mi ) is one of the leading causes of morbidity and mortality throughout the world . in china , a newly industrialized country , it is estimated that 3 million patients have suffered from mi and an additional 0.5 million patients experience acute mi yearly .
substantial progress has been made i... | abstractcell transplantation has become an attractive option for cardiac regenerative therapy .
however , poor cell survival and extensive redistribution throughout the body can drastically affect the outcome and safety of cell therapy .
although various approaches have been attempted to support the survival and en... |
the quality of life ( qol ) assessment in elderly people has been a priority in many developed countries to guide public policy , including social , health , and environmental actions . the world health organization ( who ) developed an international cross - culturally comparable qol assessment instrument , whoqol . to... | purpose : to assess the quality of life ( qol ) of elderly people in the academia da cidade program
( acp ) , a public brazilian government program encourages physical and leisure activity in recife , brazil.materials and methods : this cross - sectional study evaluated 181 elderly people attending the acp at leas... |
adults with type 2 diabetes inadequately controlled ( a1c 711% ) with maximally tolerated stable doses of metformin , sulfonylurea , or both for 3 months were randomized ( 1:1 ) to 1.8 mg liraglutide once daily or 10 g exenatide twice daily .
after 26 weeks , patients continued into a nonrandomized 14-week extension ... | objectiveto evaluate efficacy and safety of switching from twice - daily exenatide to once - daily liraglutide or of 40 weeks of continuous liraglutide therapy.research design and methodswhen added to oral antidiabetes drugs in a 26-week randomized trial ( liraglutide effect and action in diabetes [ lead]-6 ) , liraglu... |
threshold values are of prime importance in providing a sound basis for public health decisions .
a key issue is determining threshold or maximum exposure values for pollutants and assessing their potential health risks .
environmental epidemiology could be instrumental in assessing these levels , especially since ... | |
the origin of tumors of minor salivary glands account for less than 25% of all salivary neoplasms with 40
kleinsasser and klein introduced the term basal cell adenoma to describe a benign salivary gland tumor comprised of uniform appearing basaloid cells arranged in solid , trabecular , tubular , and membranous pat... | basal cell adenoma ( bca ) of the salivary glands is an uncommon type of monomorphic adenoma .
its most frequent location is the parotid gland .
it usually appears as a firm and mobile slow - growing mass .
histologically , it is seen as nests of isomorphic cells and interlaced trabeculae with a prominent basal m... |
autistic spectrum disorders ( asds ) are developmental disorders estimated to affect 1 in 150 children .
increasing professional awareness has led to higher levels of diagnosis and support , possibly explaining the recorded rise in prevalence over the last 30 years .
asd is commoner in males ( m : f autism 4 : ... | background . user feedback is now an integral part of both clinical governance and service development , and it also provides a key route to engaging parents and children .
autistic spectrum disorders ( asds ) can impact on all members of a family , and close working between parents and professionals is essential . a... |
ecology is generally described as the study of the relationships between organisms and the ( a)biotic environment .
such relationships are best understood as interactions because the environment is not only dictating the fate of organisms , but organisms also affect the environment .
organisms make use of their phe... | there is a growing recognition for the significance of evolutionary thinking in ecology and conservation biology
. however , ecology and conservation studies often work with species - specific , fixed traits that ignore intraspecific variation .
the way the habitat of a species is considered is an example of typolo... |
laparoscopic sleeve gastrectomy ( sg ) was introduced by gagner and colleagues as a first - step procedure to minimize surgical risk for super - super obese ( sso ) or high - risk patients , followed by either laparoscopic biliopancreatic diversion with duodenal switch or laparoscopic roux - en - y gastric bypass ( ryg... | background and objectives : this study evaluates our technique for robot - assisted sleeve gastrectomy for morbidly obese and super obese patients and our outcomes.methods:a retrospective analysis of patients who underwent robot - assisted sleeve gastrectomy at a single center was performed .
the procedure was perfor... |
transposons employ intricate mechanisms of excision and reinsertion , and they appear to play an important role in the evolution of their hosts , often accounting for a substantial part of the genomes [ 1 - 5 ] .
more recently , however , they have primarily attracted attention as tools for the manipulation of the ge... | transposons are powerful tools for conducting genetic manipulation and functional studies in organisms that are of scientific , economic , or medical interest
. minos , a member of the tc1/mariner family of dna transposons , exhibits a low insertional bias and transposes with high frequency in vertebrates and inverte... |
sunitinib is a small molecule multitargeted tyrosine kinase inhibitor currently used for the treatment of cancer .
this class of drugs has also been reported to have antidiabetic effects [ 1 - 3 ] , but the mechanism has not been elucidated . here
we describe a patient with a nonfunctioning pancreatic neuroendocrin... | we report a rare case of severe hypoglycemia after sunitinib treatment for pancreatic neuroendocrine carcinoma .
we describe the initial clinical presentation , laboratory results , pathologic findings , and managment in a patient with a nonfunctioning pancreatic neuroendocrine carcinoma with liver metastases who dev... |
a new distribution for analysing time - to - event data was introduced by , known as generalised exponential distribution .
generalised exponential distribution can be used as an alternative to the well - known and used weibull distribution in lifetime data analysis and reliability engineering according to .
the ge... | a unit is said to be randomly censored when the information on time occurrence of an event is not available due to either loss to followup , withdrawal , or nonoccurrence of the outcome event before the end of the study .
it is assumed in independent random / noninformative censoring that each individual has his / he... |
supernumerary teeth can occur in primary or permanent dentition , but are more frequently reported in permanent dentition .
they can occur in different forms , unilaterally or bilaterally and either in the maxilla or mandible .
supernumerary teeth may be an incidental finding on a radiograph or the cause for failur... | the presence of supernumerary teeth is not uncommon in the general population .
they occur more frequently in patients with a family history of such teeth .
it is rare to find multiple supernumeraries in individuals with no other associated disease or syndrome .
there have been very few documented cases of bilate... |
laboratory bacterial strains used are derived from e. coli k12 ( bw25113 obtained from the coli genetic stock center or mg1655 obtained from atcc ) .
the uropathogenic e. coli strain uti89 was kindly provided to us from matt conover and scott hultgren .
the ciprofloxacin - resistant uropathogenic e. coli isolate ( ... | antibiotic resistance is an increasingly serious public health threat1 .
understanding pathways allowing bacteria to survive antibiotic stress may unveil new therapeutic targets28 .
we explore the role of the bacterial epigenome in antibiotic stress survival using classical genetic tools and single - molecule real ... |
the transmission risk of foot - and - mouth disease ( fmd ) in japan was evaluated using a
mathematical fmd transmission model .
the distance - based transmission rate between farms ,
which was parameterized using the fmd epidemic data in 2010 in japan , was used to
calculate the local - level reproduction numb... | |
the population of old people is rising exponentially in thailand . according to the foundation of thai gerontology research and development institute , tgri ( 2013 )
it is projected that the aged population in thailand will significantly rise to approximately 22 million by 2040 . in 25 years , 33.5% of the entire tha... | background . there is an important need to characterize risk factors for disability in thailand , in order to inform effective prevention and control strategies .
this study investigated factors associated with risk of 6 types of disability in thailand 's ageing population in 2002 , 2007 , and 2011 .
methods .
da... |
the most common hospital - acquired infection is catheter - associated urinary tract infection ( cauti ) accounting for almost 40% of all the nosocomial infections .
the single most important predisposing factor for cauti is the insertion of urinary catheter .
urinary ( foley ) catheters are used very frequently in... | background and aims : catheter - associated urinary tract infection ( cauti ) is one of the most common health care acquired infection encountered in clinical practice .
the present study was planned to assess the knowledge and attitude of health care providers regarding the indications for catheterization and method... |
pit displays the characteristic histological features of a thymoma , with the additional characteristic of being surrounded by lung or visceral pleura without evidence of a thymic lesion in the anterosuperior mediastinum .
due to its rarity , variety , unclear natural course , and non - specific features on diagnosti... | primary intrapulmonary thymoma ( pit ) is a very rare lesion of uncertain pathogenesis .
pit should be considered when the histopathological appearance of a lung tumor shows features that are uncommon but similar to those of a thymoma . in this case report
, we discuss the case of a 59-year - old female with a soli... |
web- and mobile - phone - based applications are now commonly used to improve coverage and quality of health services . in india ,
the mother and child tracking system ( mcts ) is one such web - based applications that is used nation - wide to improve the coverage of maternal , newborn , and child health ( mnch ) ser... | background : the innovative mobile - phone technology for community health operation ( imtecho ) is a mobile - phone application that helps accredited social health activists ( ashas ) in complete registration through the strategies employed during implementation that is linking ashas incentives to digital records , re... |
recent advances in high - throughput sequencing technologies have greatly increased the scale and scope of genomics research , and this was evident throughout the recent biology of genomes meeting at the cold spring harbor laboratory . here
in one of several talks that investigated the causes , dynamics and phenotypi... | a report on the 23rd annual meeting on ' the biology of genomes ' , 11 - 15 may 2010 , cold spring harbor , usa.meeting reportrecent advances in high - throughput sequencing technologies have greatly increased the scale and scope of genomics research , and this was evident throughout the recent biology of genomes meeti... |
the three goals of radical prostatectomy ( ) are cancer control , preservation of urinary control , and preservation of sexual function. as the techniques of rp have evolved , our understanding of the relevant anatomy has improved and better oncological and functional outcomes have been reported . despite this , there... | the role of a bladder neck sparing ( bns ) technique in radical prostatectomy ( rp ) remains controversial .
the potential advantages of improved functional recovery must be weighed against oncological outcomes .
we performed a literature review to evaluate the current knowledge regarding oncological and functional... |
using a modal matching theory , we demonstrate the generation
of
short - range , chiral electromagnetic fields via the excitation of arrays
of staggered nanoslits that are chiral in two dimensions .
the electromagnetic
near fields , which exhibit a chiral density greater than that of circularly
polarized li... | |
most of us agree that the assumption that nurses care and doctors cure is too simplistic , and that it is not uncommon for many nurses not to care very much at all , and for some doctors to care a great deal .
however , in spite of this , there still is a theoretical discrepancy between nursing and medicine in re... | in this paper i introduce a theoretical framework on care developed by the norwegian nurse and philosopher kari martinsen , and i argue that this approach has relevance not only within nursing , but also within clinical medicine .
i try to substantiate this claim by analysing some of the key concepts in this approach... |
one of the major factors that can negatively affect breastfeeding is the lack of breast milk .
there are many instructions on the subject of breast milk in iranian traditional medicine resources .
this article attempts to investigate causes and reasons for the lack of breast milk from the perspective of the great s... | background : support for breastfeeding is a public health priority .
one of the major factors that can negatively affect breastfeeding is the lack of breast milk .
there are many instructions on the subject of breast milk in iranian traditional medicine resources .
this article attempts to investigate causes and ... |
over the next 30 years , the elderly population ( 65 years and older ) in the united states is expected to double . by the year 2040
, 20% of americans will be 65 years of age and older as compared to 12.97% in 2010 . from 2010 to 2050
, the total population is expected to increase by 142% ; the age group of 65 yea... | this study was conducted to evaluate recipients ' perception of service quality , satisfaction , and behavioral intention in home delivered meals program in the us . out of 398 questionnaires , 265 ( 66.6% )
were collected , and 209 questionnaires ( 52.5% ) were used for the statistical analysis . a confirmatory fact... |
globally , the production of canned tuna is continuously increasing and the current european market demand far exceeds the availability of raw material that the fishing areas of the european union ( eu ) are able to provide , forcing fish processing companies to seek new and cheaper sources of supply , such as zero dut... | the results of a study on the microbiological stability of canned tuna produced by italian companies and similar canned products manufactured in countries outside europe are reported herein .
the study involved 38 samples of canned tuna of various brands , of which 14 were produced by companies outside europe and 24 ... |
mycotic aortic aneurysms are a rare condition with a relative incidence of 13% of all aortic aneurysms .
the patients often present late with nonspecific symptoms , and these aneurysms are prone to rupture ; therefore , early diagnosis and urgent treatment is vital . computed tomography angiography ( cta ) is the fir... | mycotic aortic aneurysms account for 13% of all aortic aneurysms .
the management of this disease is controversial .
since open surgical repair is associated with high morbidity and mortality rates , endovascular aneurysm repair is an alternative treatment method with promising early and midterm outcomes , although... |
birth of a child with ambiguous genitalia often imparts great deal of apprehension and confusion to the involved families . diagnostic workup and timely designation of the gender to these patients
clitoromegaly refers to an abnormal enlargement of a female clitoris , thus masquerading as a male penis .
most of the ... | genitourinary involvement of neurofibromatosis is uncommon and genital neurofibromatosis is even rarer .
involvement of clitoris by neurofibroma can lead to clitoromegaly masquerading as a male penis .
we report such a case of ambiguous genitalia in a 7-year - old female child presenting with clitoromegaly since bi... |
a significant quantity of food and beverages arrive on the market in a robust form of tinplate packaging .
hermetically sealed can allow minimization of headspace oxygen and also keep a long and safe shelf life with minimal use of preservatives . however , the use of tinplate for food and beverage packing will result... | tin content in samples of canned fruits and vegetables was determined by hydride generation inductively coupled plasma atomic emission spectrometry ( hg - icp - oes ) , and it was compared with results obtained by standard method of flame atomic absorption spectrometry ( aas ) . selected tin emission lines intensity wa... |
the endothelium , the monolayer of endothelial cells lining the lumen of all blood vessels , plays an important role in the regulation of vasomotor tone control with the release of vasoconstrictor mediators.1 endothelial function can be assessed by flow - mediated dilatation ( fmd ) which be carried out noninvasively w... | background : the ankle - brachial pressure index ( abi ) , the ratio of the systolic blood pressure of the ankle to the systolic brachial pressure , is commonly measured at rest , but abi values post - exercise enhance the sensitivity of the test and can be used to identify atherosclerotic vascular damage .
however ,... |
increased microglial activity facilitates beneficial responses to central nervous system ( cns ) injuries , including phagocytosis of debris and clearance of apoptotic cells ; however , unregulated microglial activity can lead to production of neurotoxic factors that worsen cns pathology and cause neuronal degeneration... | the role of inflammation in neurodegenerative diseases has been widely demonstrated .
intraneuronal protein accumulation may regulate microglial activity via the fractalkine ( cx3cl1 ) signaling pathway that provides a mechanism through which neurons communicate with microglia .
cx3cl1 levels fluctuate in different... |
despite their usually low stability , organic radical cations1 , 2 have raised substantial interest in a wide range of research areas owing to their critical importance in a multitude of organic and biological reactions , for which they act as reactive intermediates .
furthermore , radical cations that absorb light i... | abstractchemical or electrochemical oneelectron oxidation of 5narylaminothiazoles was found to afford stable radical cations . for chemical oxidation , 1 equivalent of [ ( 4brc6h4)3n][sbcl6 ] ( magic blue , mb )
was added to ch2cl2 solutions of the thiazoles , and the thusobtained radicals showed light absorption in... |
emergency hematopoiesis defines the production of functional hematopoietic cells under nonhomeostatic , proinflammatory , or biologically stressed conditions [ 14 ] .
blood cell production is a tightly regulated process that , after birth and throughout life , starts in a conspicuous hematopoietic stem cell ( hsc ) s... | reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem / progenitor cells within the bone marrow .
although in the last decade the use of dialyzable leukocyte extracts ( dle ) as... |
the accord trial design , inclusion criteria , subject characteristics , and main results have been previously published ( 2 ) .
the accord trial was designed to determine whether cardiovascular event rates in t2 dm could be reduced through intensive glycemic control , intensive blood pressure control , and lipid man... | objectiveidentify determinants of weight gain in people with type 2 diabetes mellitus ( t2 dm ) allocated to intensive versus standard glycemic control in the action to control cardiovascular risk in diabetes ( accord ) trial.research design and methodswe studied determinants of weight gain over 2 years in 8,929 partic... |
abdominal compartment syndrome ( acs ) is a life - threatening syndrome with an increase in incidence among critically ill patients .
primary acs results from a direct injury within the abdomen and pelvic region ( e.g. , a blunt or penetrating trauma , ruptured abdominal aortic aneurysm or laparotomy ) . a direct inj... | introduction : an increase in abdominal pressure can lead to so - called intra abdominal compartment syndrome ( acs ) .
multiple factors such as an increase in retroperitoneal volume due to pancreatitis , bleeding and edema as a result of pelvic fracture can lead to compartment syndrome .
prevention is better than... |
the prevalence of electronic nicotine delivery systems ( ends ) , such as ecigarettes and vapor pens , is on the rise around the world 1 .
while ecigarettes may have potential roles in assisting with smoking cessation or tobacco harm reduction 2 , they are not currently approved or regulated by the food and drug admi... | key clinical messagealthough use of electronic nicotine delivery system devices , such as ecigarettes and vapor pens , is on the rise , no treatment protocols exist to help such users quit .
we report the case of a 24yearold patient in a tobacco treatment program who successfully quit ecigarette use by using nicotine... |
biomonitoring is an important way of evaluating human exposures to selected environmental contaminants and is becoming more widely used in public health work .
creatinine is often used for normalizing or adjusting urinary analyte concentrations for dilution in clinical samples and is considered an integral part of mo... | a viable , quick , and reliable method for determining urinary creatinine by liquid chromatography / tandem mass spectrometry ( lc / ms / ms ) was developed and used to evaluate spot urine samples collected for the washington environmental biomonitoring survey ( webs ) : part of the washington state department of healt... |
we report a case of a 32 week gestation newborn diagnosed with a right ventricular outflow tract mass and subsequently diagnosed with tuberose sclerosis that needed early surgical intervention .
while this case needed early intervention , the need for surgical intervention in otherwise asymptomatic cases is debata... | backgroundneonatal tuberose sclerosis complex may be associated with symptomatic cardiac rhabdomyomas .
cardiac rhabdomyomas are the most common cardiac tumours .
the symptoms include haemodynamic instability and life threatening arrhythmias usually requiring early surgical intervention.resultswe report a case of a... |
the hormones dominating the phases are gonadotropin releasing hormone ( gnrh ) ,
follicle - stimulating hormone ( fsh ) , luteinizing hormone ( lh ) , estrogen and progesterone .
these hormones can be changed by exercise estrogen and progesterone increase after acute
exercise . in the menstrual period ,
progest... | [ purpose ] the performance of female athletes during their menstrual period has attracted
the attention of researchers for many years . it is known that the menstrual period changes
with exercise . alpha - fetoprotein ( afp ) is an oncofetal protein . in this study ,
the effect
of maximal aerobic exercise in t... |
chronic heart failure ( hf ) is a significant health and social problem . in the united states alone , nearly 6 million people suffered from hf in 2008 , and this disease is becoming increasingly prevalent with more than 550,000 new cases diagnosed each year .
half of hf patients die within 5 years of the first ons... | background . chronic heart failure is a major health and social problem .
the promotion of self - care behaviours can potentially assist patients to effectively manage this chronic condition and prevent worsening of the disease .
formal personalized educational interventions that provide support and take into consi... |
diabetic muscle infarction ( dmi ) , which was described for the first time by angervall and stener in 1965 , is a rare complication of dm .
it is usually seen in long - standing dm along with complications , such as , nephropathy , retinopathy and neuropathy . until now
it commonly occurs in the thigh muscles and ... | diabetic muscle infarction ( dmi ) is an unusual complication of diabetes mellitus .
it is usually seen in long - standing diabetes mellitus .
this article presents a case of dmi in the left forearm of a 58-year - old woman .
she had a swollen forearm .
the level of creatine kinase was 5930
u / l .
her cond... |
a 43-year - old man had sudden blurring of vision , metamorphopsia , and paracentral scotoma in his left eye on the second postoperative day of dacryocystorhinostomy operation on the same side .
ocular examination showed best - corrected visual acuity of 20/20 in the right eye and 20/80 in the left eye .
fundus flu... | a 43-year - old man developed central serous choroidoretinopathy in his left eye following dacryocystorhinostomy operation on the same side .
he was using xylometazoline nasal drops in his left nostril .
action of xylometazoline or the stress related to the operation or the effect of both factors played the role in... |
the use of sound information is a growing area of application of signal processing techniques in healthcare and biomedicine .
in particular , multiple groups have reported on the development of systems that analyze audio recordings of patients and identify bouts of coughing [ 15 ] or other sounds indicative of health... | the development of an automated system for asthma monitoring ( adam ) is described .
this consists of a consumer electronics mobile platform running a custom application .
the application acquires an audio signal from an external user - worn microphone connected to the device analog - to - digital converter ( micro... |
camel milk has been used for centuries as a medicinal drink in middle eastern , asian , and african cultures ( 13 ) .
camel milk products in the world are popular due to increasing demand and are typically available in pharmacies ( 4 ) .
this systematic review has been conducted to evaluate the nutritional value an... | introductioncamel milk is the closest to a human mother s milk .
camel milk is different from other milks , however , having low sugar and cholesterol , high minerals ( sodium , potassium , iron , copper , zinc and magnesium , and vitamin c ) .
the milk is considered have medicinal characteristics as well .
this ... |
tear film studies have progressed a lot in the past few years , from the traditional quantitative tests like schirmer test , and tear meniscus height measurement , and the qualitative test of tear break - up time ( tbut ) , to anterior segment optical coherence tomography ( as oct ) measured tear film height and the dy... | purpose . to assess the tear film quantity and correlate it with the quality and stability of the tear film in diabetics and compare them to age matched controls .
introduction .
diabetes affects tear film parameters in multiple ways .
poor metabolic control and neuropathy are postulated factors .
to further un... |
freeze - fracture electron microscopy was established as a major technique in ultrastructure research over 30 years ago .
when biological specimens are in the frozen state , cellular bilayer lipid membranes have a plane of weakness in their hydrophobic interior ; so if the sample is fractured , the fracture plane wil... | lipid droplets are not merely storage depots for superfluous intracellular lipids in times of hyperlipidemic stress , but metabolically active organelles involved in cellular homeostasis . our concepts on the metabolic functions of lipid droplets have come from studies on lipid droplet - associated proteins .
this re... |
thyroid eye disease ( ted ) is an autoimmune disease involving the retroocular tissues associated with graves ' disease [ 1 , 2 ] .
typical signs and symptoms include proptosis , retroorbital pain , tearing , conjunctival redness and edema , corneal lesions , impaired extraocular motility with or without diplopia , p... | background / aim . to evaluate the efficacy of methotrexate for the treatment of thyroid eye disease ( ted )
.
methods . 36 consecutive patients with active ted , previously treated with corticosteroids but stopped due to the occurrence of side effects , were commenced on methotrexate therapy .
two different week... |
genital herpes is most commonly caused by infection with herpes simplex virus type 2 ( hsv-2 ) , and is one of the most prevalent sexually transmitted diseases ( std ) worldwide [ 13 ] .
the incidence of new infections is about 1 million cases per year in the united states .
at least 50 million persons in the unite... | objective . genital herpes ( gh ) recurrences and viral shedding are more frequent in the first year after initial hsv-2 infection .
the objective of this study was to provide the first evaluation of valacyclovir 1 g once daily compared to placebo in reducing viral shedding in subjects newly diagnosed with gh . metho... |
dengue is an arboviral disease endemic in most of the tropical countries with recurrent epidemics .
although dengue is known to cause hepatic involvement commonly , it only occasionally results in fulminant liver failure ( flf ) , which has a high mortality .
n - acetyl cysteine ( nac ) , a precursor of glutathione... | consensus on management of complicated cases of dengue infection is evolving . dengue hemorrhagic fever ( dhf ) occasionally progress to fulminant liver failure with high fatality rate .
inadvertent use of blood products to control massive bleeding in dengue shock syndrome may worsen fluid overload and subsequently t... |
the choroid , a well - vascularized connective tissue , resides between the retina pigment epithelium and the sclera and extends from the ora serrata anteriorly to the optic nerve posteriorly .
the choroid receives most of the ocular blood flow ( ~85% ) and has one of the highest metabolic activities in the body .
... | aimthe objective of the study reported here was to investigate the normal peripapillary choroidal thickness ( ct ) , measured by enhanced depth imaging optical coherence tomography ( edi - oct ) , in healthy turkish volunteers.materials and methodsin this prospective cross - sectional study , 57 eyes of 57 healthy turk... |
applying optimum amount of force during orthodontic treatment is a challenging task for the orthodontist .
amount of force to be applied during orthodontic treatment is one of the problems encountered in orthodontics.1 the quantification of stress in the periodontal ligament ( pdl ) is an important concept , as stres... | background : simulation of periodontal ligament ( pdl ) using non - linear finite element method ( fem ) analysis gives better insight into understanding of the biology of tooth movement .
the stresses in the pdl were evaluated for intrusion and lingual root torque using non - linear properties.materials and methods ... |
cryptophane - a
was the first cryptophane synthesized by collet et
al . in 1981 .
it is composed of two equivalent
cyclotribenzylene ( ctb ) caps bound together by three ethylene - dioxy
linkers . on each phenyl ring
a
has been the subject of many interesting studies in the field of host
it has a hydrop... | host guest
complexes between cryptophane - a as host and dichloromethane
and chloroform as guests are investigated using 1h and 13c nmr spectroscopy .
moreover , a related cryptophane , with
the methoxy groups replaced by butoxy units ( cryptophane - but ) , and
its complexes with the same guests were also s... |
acute myocardial ischemic injury is associated with various pathophysiological responses , including inflammatory activity with migration of neutrophils to the ischemic site .
although early blood reperfusion to the ischemic myocardium is undoubtedly beneficial in the setting of acute myocardial infarction , there is... | backgroundacute myocardial infarction is associated with tissue inflammation .
early coronary reperfusion clearly improves the outcome but may help propagate the inflammatory response and enhance tissue damage .
cyclooxygenase-2 is an enzyme that catalyzes the initial step in the formation of inflammatory prostagla... |
migraine is a highly prevalent illness , and women of reproductive ages are more affected by it than men or women in other age groups ( 1 ) .
many researchers have supported the view that behavioral interventions such as biofeedback and relaxation , either alone or in combination , can be effective for the treatment ... | biofeedback with or without combined autogenic training is known to be effective for the treatment of migraine .
this study aimed to examine the effect of biofeedback treatment on headache activity , anxiety , and depression in korean female patients with migraine headache .
patients were randomized into the treatm... |
the emerging discipline of cancer survivorship research includes the study of the consequences of cancer diagnosis and its treatment among children and adults who have experienced cancer .
while the united states ( usa ) has conducted the majority of research on adult cancer survivorship [ 26 ] , the united kingdom a... | cancer survivorship research includes the study of physical , psychosocial , and economic consequences of cancer diagnosis and treatment among pediatric and adult cancer survivors . historically , the majority of cancer survivorship studies were from the united states , but survivorship issues are increasingly being ad... |
currently , the uniprotkb protein sequence database contains > 17 million protein sequences ( 1 ) .
this wealth of data is helping us to understand biology at an ever increasing rate .
a large fraction of these sequences can be grouped into a few thousand common protein families .
proteins within these families o... | as the deluge of genomic dna sequence grows the fraction of protein sequences that have been manually curated falls . in turn , as the number of laboratories with the ability to sequence genomes in a high - throughput manner grows , the informatics capability of those labs to accurately identify and annotate all genes ... |
luminescent metal complexes
are increasingly employed as biomolecular and cellular probes due
to their unique photophysical properties that make them particularly
well suited to monitor biological processes .
examples include not only complexes of transition metals such as
pt , ir , and ru but also those that... | a systematic
study of the effect of hydrophobicity and charge on the cell viability
and cell association of lanthanide metal complexes is presented .
the
terbium luminescent probes feature a macrocyclic polyaminocarboxylate
ligand ( dota ) in which the hydrophobicity of the antenna and that
of the carboxyam... |
mandibular angle fracture is the most common mandibular fracture , accounting for 40% of all mandibular fractures1 .
mandibular angle fracture is defined as a fracture line between the anterior border of the mandibular ramus and the body of the mandible2 .
the management of angle fracture is difficult because of it... | objectivesthe aim of this study was to evaluate the implication of third molars in postoperative complications of mandibular angle fracture with open reduction and internal fixation ( orif).materials and methodsdata were collected on patients who presented with mandibular angle fracture at our department of oral and ma... |
the incidence of hepatocellular carcinoma ( hcc ) is increasing in the united states , europe , and worldwide , and has become a serious problem in many countries .
patients with chronic liver disease related to hepatitis b or c virus infection are at high risk for developing hcc , and the risk of hcc development bec... | a 41-year - old japanese man had received successful interferon ( ifn ) therapy against chronic hepatitis c in 1994 . since then , serum hepatitis c virus ( hcv ) rna had been negative , and aminotransferase levels had been continuously normal .
he had abstained from alcohol . however , his serum aminotransferase lev... |
over 40% of patients being treated with oral anticoagulation are prescribed a direct oral anticoagulants ( doacs ) according to a recent study assessing prescribing patterns 1 .
pivotal trials for the doacs have reported noninferiority or superiority of these agents to warfarin , a vitamin k antagonist ( vka ) , for ... | key clinical messagewe presented the first case of fourfactor prothrombin complex concentrate ( 4fpcc ) for the alleviation of bleeding for emergent onpump coronary artery bypass graft ( cabg ) with the patient discharged by postoperative day ( pod ) 9 with no sequelae .
until direct antidotes are available , 4fpcc m... |
the neural mechanisms that underlie l - dopa - induced dyskinesias in
parkinson s disease ( pd ) remain poorly understood [ 14 ] .
dyskinesias have
been associated with pulsatile stimulation of dopamine receptors , downstream
changes in genes and proteins , and changes in nondopamine transmitter systems
[ 46 ... | we studied whether five sessions of 10 hz repetitive transcranial magnetic stimulation ( rtms treatment ) applied over the dorsolateral prefrontal cortex ( dlpfc ) or the primary motor cortex ( mc ) in advanced parkinson 's disease ( pd ) patients would have any effect on l - dopa - induced dyskinesias and cortical ex... |
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