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the thalamic reticular nucleus ( trn ) is hypothesized to regulate neocortical rhythms and behavioral state . using optogenetics and multi - electrode recording in behaving mice , we found that brief selective drive of trn switched thalamocortical firing mode from tonic to bursting and generated state - dependent neo...
squamous cell carcinoma ( scc ) after ileal pouch - anal anastomosis ( ipaa ) for ulcerative colitis ( uc ) is very rare [ 1 , 2 ] . scc is extremely sensitive to chemoradiation therapy ( crt ) , but an ileal pouch is generally considered a contraindication to radiotherapy . few cases of scc in ipaa patients have b...
backgroundfew cases of pouch - related cancers have been reported in ulcerative colitis ( uc ) , and squamous cell carcinoma ( scc ) is very rare.methoda systematic review of the literature was performed to identify all unequivocal cases of pouch - related scc in uc patients.resultseight cases of scc developing after i...
carpal tunnel syndrome ( cts ) represents the most common compressive peripheral neuropathy , predominantly presenting as a tingling sensation , pain and numbness in the distribution of the median nerve and it is estimated to affect about 1% of the population33,37 ) . cts is usually diagnosed on the basis of the pati...
objectivein most patients with carpal tunnel syndrome ( cts ) , pain and/or paresthesia disappeared or decreased in a month after endoscopic carpal tunnel release ( ectr ) . however , subpopulation of patients showed delayed improvement following ectr . we analyzed the delayed improvement hands to investigate the c...
our synthesis was initiated with chromone 12 which was prepared in greater than 50 gram batches and purified by recrystallization ( figure 2 ) . utilizing diisopropylsilyl ditriflate to activate chromone 12 to a siloxybenzopyrylium species , vinylogous addition of 2-trimethylsiloxyfuran was achieved which was followe...
chiral , dimeric natural products containing complex structures and interesting biological properties have inspired chemists and biologists for decades . a seven step total synthesis of the axially chiral , dimeric tetrahydroxanthone natural product rugulotrosin a is described . the synthesis employs a one - pot suzu...
the term synapse has been defined as a specialized structure allowing the functional interaction between neurons . this structure has morphologic and functional characteristics capable of directing and modulating neuronal signals . following the classical studies of furshpan and potter , it was recognized that be...
abstract : backgroundgap junctions are clusters of intercellular channels allowing the bidirectional pass of ions directly into the cytoplasm of adjacent cells . electrical coupling mediated by gap junctions plays a role in the generation of highly synchronized electrical activity . the hypersynchronous neuronal acti...
malaria is caused by protozoan parasites of the genus plasmodium , namely , p. falciparum , p. vivax , p. malariae , p. ovale , and p. knowlesi . patients with p. falciparum infection are prone to develop severe malaria in 30% of cases , which resulted in case fatality rate of 20% . in southeast asia , acute renal ...
there are limited data on the application of the rifle criteria among patients with severe malaria . this retrospective study was conducted by reviewing 257 medical records of adult hospitalized patients with severe falciparum malaria at the mae sot general hospital , tak province in the northern part of thailand . ...
the hi contribution rates applicable to taxable earnings in each of the calendar years 1981 and later are shown in table 1 . after 1983 , the automatic increase provisions in section 230 of the social security act determine the maximum taxable amount . the social security act was amended during 1982 by the tax equi...
this summary presents an overview of the information contained in the annual reports of the trustees required under title xviii of the social security act , health insurance for the aged and disabled , commonly known as medicare . there are two basic programs under medicare : hospital insurance ( hi ) , which pays ...
an alternative approach is active breath - hold , which is a temporary suspension of breathing at a desired respiratory phase . however , it is argued that the suspension mechanism facilitates the protection of the heart better in breast cancer patients than in lung cancer patients who tend to have a smaller breathin...
we propose a clinical workflow of stereotactic volumetric modulated arc therapy ( vmat ) for a lung tumor from planning to tumor position verification using 4d planning computed tomography ( ct ) and 4d cone - beam ct ( cbct ) . a 4d ct scanner , an anzai belt and a bodyfix were employed to obtain 10-phase respirator...
progress in immunotherapy has provided novel insights into the roles of tumor - infiltrating lymphocytes ( tils ) in cancer . the prognostic significance of tils has been determined in breast cancers , particularly human epidermal growth factor receptor 2 ( her2)positive breast cancers and triple - negative breast ca...
purposethe prognostic significance of tumor - infiltrating lymphocytes ( tils ) has been determined in breast cancers . interferons can affect t - cell activity through direct and indirect mechanisms . myxovirus resistance a ( mxa ) is an excellent marker of interferon activity . here , we evaluated tils and mxa ...
insects : adults of l. f. fossarum ( p generation ) were collected from ishigaki island ( 2422 - 27n , 1249 - 12e ) , okinawa prefecture , ryukyu archipelago , japan . twenty - six females and 16 females were obtained on 3 april and 13 august 2012 , respectively . collected adult females were maintained with d. mel...
the water strider limnogonus fossarum fossarum ( f. ) ( hemiptera : gerridae ) shows a macropterous , micropterous , and apterous polymorphism . although a long photoperiod condition induces winged morphs , preliminary studies have revealed that crossing between winged morphs increased the proportion of macropterous ...
a total of 160 fecal samples were collected in june and july 2014 from large - bodied gulls at two sites from each of two general locations within southcentral alaska 1 ) . middleton island is a remote location in southcentral alaska , approximately 115 km offshore from the mainland in the gulf of alaska . middleto...
backgroundantibiotic - resistant bacteria pose challenges to healthcare delivery systems globally ; however , limited information is available regarding the prevalence and spread of such bacteria in the environment . the aim of this study was to compare the prevalence of antibiotic - resistant bacteria in large - bod...
the extensive use of pesticides harms the soil [ 14 ] , air [ 5 , 6 ] , food [ 710 ] surface and ground waters [ 1114 ] , and quality causing serious impacts on the environment and on human health . in natural waters pesticide residues are present at very low levels and can be degraded when submitted to lower ph leve...
this paper describes a simple and quick method for sampling and also for carrying out the preconcentration of pesticides in environmental water matrices using two - phased hollow fiber liquid phase microextraction ( hf - lpme ) . factors such as extraction mode , time , solvents , agitation , and salt addition were i...
medical records from the university of missouri veterinary medical teaching hospital and the university of minnesota veterinary medical center were reviewed to identify dogs that were diagnosed with severe sas between september 1999 and january 2011 . information regarding signalment , age at diagnosis , echocardiogr...
backgroundsubaortic stenosis ( sas ) is one of the most common congenital cardiac defects in dogs . severe sas frequently is treated with a beta adrenergic receptor blocker ( beta blocker ) , but this approach largely is empirical.objectiveto determine the influence of beta blocker treatment on survival time in dogs ...
the cannabinoid receptors , endocannabinoids and the proteins for their biosynthesis and degradation constitute the key components of the endocannabinoid system ( di marzo et al . , 1998 ) . cb1 receptors and endocannabinoids are highly expressed in the basal ganglia and have close connections with the dopaminergic s...
there is substantial evidence supporting a role for the endocannabinoid system as a modulator of the dopaminergic activity in the basal ganglia , a forebrain system that integrates cortical information to coordinate motor activity regulating signals . in fact , the administration of plant - derived , synthetic or end...
lipoma arborescens ( la ) is a rare , benign intra - articular lesion most commonly found in the knee , characterised by villous proliferation of the synovium . it generally presents as a longstanding , slowly progressive swelling of one or more joints associated which may or may not be associated with pain . mri i...
introduction : lipoma arborescens ( la ) is a rare , benign intra - articular lesion most commonly found in the knee , characterised by villous proliferation of the synovium . it generally presents as a longstanding , slowly progressive swelling of one or more joints associated which may or may not be associated with...
oxidants are important in the regulation of signal transduction and gene expression . multiple classes of genes are transcriptionally activated by oxidants and are implicated in different phenotypic responses . in the present study , we performed differential mrna display to elucidate genes that are induced or repres...
in addition to possessing an extraordinary sweeping activity , pulmonary alveolar macrophages ( pam ) are equipped with the biochemical mechanisms involved in the metabolism of carcinogens , which were found to be inducible in humans by cigarette smoke . moreover , several defense processes were stimulated in rat pam...
several cases of desmoplastic ameloblastoma ( da ) of the maxilla that extended into the maxillary sinus have been described,[15 ] but there has been no report of da occupying the entire sinus . here , we report a rare case of a da lesion that filled the entire maxillary sinus . the patient was a 29-year - old japa...
we report a rare case of desmoplastic ameloblastoma lesion that filled the entire maxillary sinus . the patient visited our hospital with a chief complaint of swelling around the upper left premolars . a panoramic x - ray captured an image of a mixture of ill - defined radiolucency and radiopacity from the swollen ...
multiple sclerosis ( ms ) is a disorder of the central nervous system that affects over 500,000 europeans . the disorder affects three times as many women as men and is more prevalent in northern europe . the social costs associated with ms are high due to its long duration , the early loss of productivity , the ne...
the clinical outcome of autologous adipose stem cell ( asc ) treatment of patients with multiple sclerosis ( ms ) was investigated following one year of observation . methods . the clinical and mri outcomes of 16 asc - treated patients with rrms and spms are reported after a one - year follow - up period . results ...
candida is one of the most frequently recovered pathogens in patients with hospital acquired bloodstream infections [ 13 ] , where it is associated with a mortality rate from 30 to more than 60% in case of septic shock [ 48 ] . major risk factors for candida colonization include length of intensive care unit ( icu ) ...
the potential of the systemic antifungal treatment of non - immunocompromised patients with sepsis , extra - digestive candida colonization and multiple organ failure is unknown , although it represents three out of four antifungal treatments prescribed in intensive care units . it may allow an early treatment of inv...
the first human blood group , that is , the abo system discovered by landsteiner,1 is the most commonly used blood system although many blood systems have been identified so far . the discovery of abo system and findings of red cell agglutination in serum and recognition of blood groups laid the scientific basis for ...
objectivesthe purpose of the present study was to determine whether there was a relationship between periodontal diseases and abo blood groups.methodsthis epidemiological study was carried out on 1351 subjects who were randomly selected from individuals referred to the faculty of dentistry clinics for periodontal treat...
emergence of new technologies in food preservation leads to a reduction in the levels of preservatives and promotes the use of naturally derived antimicrobials of animal , plants , and microbial origin . egyptians , chinese , and indians used spices and essential oils since ancient time . some of the spices such as ...
in the present investigation , comparison of antimicrobial activities of different spices , curcuma longa , zingiber officinale , and mentha arvensis , and medicinal herbs , such as withania somnifera , rauvolfia serpentina , emblica officinalis , terminalia arjuna , and centella asiatica , was evaluated . different ...
while these drugs kill tumor cells , they can also cause adverse effects during their use , such as nausea , vomiting , diarrhea , constipation , alopecia , fatigue , skin alterations , and neurotoxicity , among others . chemotherapy - induced peripheral neuropathy ( cipn ) is a nuisance and a limiting side effec...
[ purpose ] the aim of this double - blind , randomized and placebo - controlled study is to investigate the effects of transcutaneous electrical nerve stimulation for reducing the side effects of chemotherapy - induced peripheral neuropathy in cancer patients undergoing chemotherapy with oxaloplatin or paclitaxe...
endoscopic submucosal dissection ( esd ) was developed in japan for the treatment of early gastric cancer , and it is now also widely used to treat superficial esophageal cancer . since esd enables the removal of large cancerous lesions from the superficial layer of the esophagus , the indications for endoscopic dissec...
we report here a case of esophageal perforation made by an endoscope while treating cicatrical stenosis that developed after wide circumferential dissection of superficial esophageal carcinoma . perforation closure with a conventional endoclip was difficult as the perforation was large and the surrounding tissue was ...
antimonide semiconductors have potential application in a wide range of electronic and opto - electronic devices due to their unique band - structure alignments , and small effective mass as well as high mobility for electrons [ 1 - 4 ] . while recent technical advancements have enabled high quality lattice matched g...
we report structural analysis of completely relaxed gasb epitaxial layers deposited monolithically on gaas substrates using interfacial misfit ( imf ) array growth mode . unlike the traditional tetragonal distortion approach , strain due to the lattice mismatch is spontaneously relieved at the heterointerface in this g...
a 20-year - old female with extensive terminal ileal and colonic crohn 's disease was initially successfully managed on a drug regimen of prednisolone and mesalazine which helped to induce remission . this maintained her disease remission but was associated with neutropenic sepsis , necessitating the withdrawal of th...
anti - tnf- agents are currently utilised for the treatment of a vast array of autoimmune conditions including inflammatory bowel disease , rheumatoid arthritis , ankylosing spondylitis and psoriasis . it is however noted that such therapeutic strategies have been linked to the specific induction of cutaneous - based...
according to classic anatomical textbooks , the suprascapular artery is the first ( lower ) branch of the thyrocervical trunk and runs transversely in the posterior cervical triangle , parallel , behind , and above the clavicle . the artery first courses laterally , in front of the scalene anterior muscle and the phr...
background : variations concerning the origin and course of the suprascapular artery are numerous and present important clinical implications.aim:in the present study the origin and course of the suprascapular artery are investigated in a sample of greek ( caucasian ) origin.materials and methods : the anatomy and cour...
a three - month - old male presented with cough , sputum , and intermittent cyanosis that had lasted for one week . a postoperative esophagogram showed a bronchoesophageal fistula , and a secondary operation involving fistulectomy and right lower and middle bilobectomy was performed . nevertheless , he required rig...
postpneumonectomy syndrome ( pps ) is a rare late complication of pneumonectomy . it occurs more often in children than in adults , and is characterized by respiratory failure resulting from bronchial compression caused by severe mediastinal shift . various methods have been used to treat pps , including aortopexy ...
treating complex regional pain syndrome ( crps ) is difficult because it still does not have a recommended therapy . a 29-year - old man was diagnosed with crps after surgery on his 4 and 5 left toes 7 years ago . though he had undergone diverse pain treatment , the symptoms persisted , so he visited dunsan korean me...
objectives : treating complex regional pain syndrome ( crps ) is difficult because it still does not have a recommended therapy . a 29-year - old man was diagnosed with crps after surgery on his 4th and 5th left toes 7 years ago . though he had undergone diverse pain treatment , the symptoms persisted , so he visited d...
details of mgs subject recruitment and sample characteristics are provided in the online full methods ( section a1 ) . samples ( 5.3% ) were excluded for high missing data rates , outlier proportions of heterozygous genotypes , incorrect sex or genotypic relatedness to other subjects . snps ( 7% for african america...
schizophrenia , a devastating psychiatric disorder , has a prevalence of 0.51% , with high heritability ( 8085% ) and complex transmission.1 recent studies implicate rare , large , high - penetrance copy number variants ( cnvs ) in some cases2 , but it is not known what genes or biological mechanisms underlie susceptib...
directed assembly of gold nanorods through the use of dithiolated molecular linkers is one of the most efficient methodologies for the morphologically controlled tip - to - tip assembly of this type of anisotropic nanocrystals . however , in a direct analogy to molecular polymerization synthesis , this process ...
appendiceal abscesses represent 2.3% of all the cases of acute appendicitis and usually present a mass in the right lower quadrant . occasionally , abscesses develop in the right subhepatic space , right subdiaphragmatic space and right pararenal space or liver . recently , the ultrasonic or ct guided percutaneous ...
the appendiceal abscess is a common complication of acute appendicitis and usually is located in the right lower quadrant of the abdomen . an epigastric appendiceal abscess has never been reported at an unusual location.we experienced an unusual case of a 49-year - old man with an epigastric appendiceal abscess . i...
it is definitely not a matter of dispute that chemotherapy and its constituent cytotoxic agents play a vital role in the clinical management of the vast majority of cancer conditions . chemotherapy measures focus on eradication of tumour presence or ( at least ) control the degree of tumour progression and metastasis...
the implementation of cytotoxic chemotherapeutic drugs in the fight against cancer has played an invariably essential role for minimizing the extent of tumour progression and/or metastases in the patient and thus allowing for longer event free survival periods following chemotherapy . however , such therapeutics are ...
prior to use of ophthalmic non - steroidal anti - inflammatory suspensions , topical ophthalmic steroids were the mainstay treatment of post - operative , surgically induced ocular inflammation . although considered very effective , the use of topical corticosteroids is limited by well known side effects which in som...
the removal of diclofenac sodium ophthalmic solution as a viable pharmaceutical entity in september 1999 from the us market spurred considerable interest in the general safety and effectiveness of topical ophthalmic nsaids for treatment of anterior segment inflammation . in late 1999 the use of topical ocular nsaids ...
lab courses have been a staple of the undergraduate biology curriculum since its inception , but too often the labs have taken on a cookbook form where students follow a protocol , much like a recipe , to obtain a known answer ( 24 , 34 ) . bio2010 ( 26 ) and vision and change ( 6 ) advocate shifting how we teach ...
the shift from cookbook to authentic research - based lab courses in undergraduate biology necessitates the need for evaluation and assessment of these novel courses . although the biology education community has made progress in this area , it is important that we interpret the effectiveness of these courses with ca...
overweight and obesity in childhood are recognised as a major health problem worldwide and while considerable data have been published relating to influences such as sedentary behaviour and nutritional habits on weight status , there is a dearth of information pertaining to the structural and functional limitations o...
although prior studies have suggested that overweight and obesity in childhood are associated with poorer functional movement performance , no study appears to have examined this issue in a pediatric population . the relations between bmi , ambulatory physical activity and functional movement screen ( fms ) performan...
murrah buffalo bulls were divided into two groups : g1 contained four 18-month - old males , and g2 contained three 24-month - old males . the animals were obtained from the department of animal production , faculty of veterinary medicine , unesp - botucatu / sp , which is located at 2253'09 " s , 4826'42 " w a...
abstract buffalo are an economically important source for meat and milk production , especially in brazil . however , important aspects of their biology remain unknown thus far . herein , we describe the reproductive characteristics of male murrah buffalo ( bubalus bubalis ) raised under extensive management ...
central serous chorioretinopathy ( cscr ) manifests as neurosensory detachment of the macula and can be attributed to focal or multifocal leakage in the retinal pigment epithelium ( rpe ) . fibrin accumulation in the subretinal space is an unusual and heretofore unreported visually damaging manifestation of severe cs...
purposecentral serous chorioretinopathy ( cscr ) manifests as neurosensory detachment of the macula and can be attributed to focal or multifocal leakage in the retinal pigment epithelium ( rpe ) . fibrin accumulation in the subretinal space is an unusual and heretofore unreported visually damaging manifestation of se...
a evoluo dos aparelhos fotopolimerizadores pode ser notada nos diferentes sistemas introduzidos recentemente no mercado . a tecnologia apresentada pelos aparelhos led promete maior tempo de vida til , no gerar aquecimento e produzir luz especfica para a ativao da canforoquinona . no entanto , ainda so necessrios es...
introduction : the evolution of light curing units can be noticed by the different systems recently introduced . the technology of led units promises longer lifetime , without heating and with production of specific light for activation of camphorquinone . however , further studies are still required to check the r...
stress echocardiography ( stress echo ) is widely applied for evaluating cardiac function [ 1 , 2 ] . motion of the left ventricle is assessed by comparing ultrasound images taken in rest and in stress stages . in the past decade , real - time three - dimensional ( 3d ) imaging has become available for quantitative...
real - time three - dimensional ( 3d ) ultrasound imaging has been proposed as an alternative for two - dimensional stress echocardiography for assessing myocardial dysfunction and underlying coronary artery disease . analysis of 3d stress echocardiography is no simple task and requires considerable expertise . in th...
( also known as eclipta prostrata roxb . ) belongs to the asteraceae family and is commonly known as false daisy in english and bhringoraj or bhringraj in bangladesh and india . it is known in the three major forms of traditional medicinal systems in the indian subcontinent , namely , ayurveda , unani , and siddha , ...
eclipta alba can be found growing wild in fallow lands of bangladesh where it is considered as a weed by farmers . traditional medicinal systems of the indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestina...
stroke is the third leading cause of death in the us after coronary artery disease and cancer and it is the leading cause of disability . extracranial atherosclerotic carotid artery disease accounts for slightly more than half of the 731,000 strokes per year in the us . a tia is a transient episode of neurological ...
revascularization of the extracranial carotid arteries is a commonly performed surgical procedure to prevent stroke . open surgery ( i.e. , carotid endarterectomy [ cea ] ) is a well - established stroke prevention procedure but is being challenged ' by a less invasive percutaneous procedure ( i.e. , carotid artery ...
water molecules are a key component of biological systems and act as ordered structural elements at binding interfaces . the mediation of ligand binding by water molecules can have important consequences for binding affinity and specificity . numerous examples of water - mediated protein ligand interactions ...
intermolecular interactions in the aqueous phase must compete with the interactions between the two binding partners and their solvating water molecules . in biological systems , water molecules in protein binding sites cluster at well - defined hydration sites and can form strong hydrogen - bonding interacti...
a total of 28 volunteers , consisting of 16 males ( age range : 25 - 29 years ; mean age : 26.9 1.2 years ) and 12 females ( age range : 20 - 38 years ; mean age : 27.8 5.5 years ) , were included in this study . all the subjects were right - handed with no history of neurological or psychiatric illness . the sub...
objectiveby using a functional magnetic resonance imaging ( fmri ) technique we assessed brain activation patterns while subjects were viewing the living environments representing natural and urban scenery.materials and methodsa total of 28 healthy right - handed subjects underwent an fmri on a 3.0 tesla mri scanner . ...
in both diabetic and non - diabetic patients , albuminuria has been recognised as an important renal and cardiovascular risk factor . although , using chemical methods , albuminuria had been detected in patients without primary renal disease more than 100 years ago , it was only after the introduction of immun...
aims / hypothesisin contrast to microalbuminuric type 2 diabetic patients , the factors correlated with urinary albumin excretion are less well known in normoalbuminuric patients . this may be important because even within the normoalbuminuric range , higher rates of albuminuria are known to be associated with higher...
trillions of microorganisms among bacteria , archaea , viruses , and fungi inhabit our gastrointestinal tract ( git ) . bacterial cells largely outnumber our own cells , and the gut microbiota is a prolific example of a symbiotic relationship as it plays a crucial role in host 's physiology and health . studies based...
over the past decade , growing evidence has established the gut microbiota as one of the most important determinants of metabolic disorders such as obesity and type 2 diabetes . indeed , obesogenic diet can drastically alter bacterial populations ( i.e. , dysbiosis ) leading to activation of pro - inflammatory mechan...
isolates - ninety - one gas isolates recovered from oropharynx secretions were included in this study . clinical specimens were processed during routine diagnoses by one clinical laboratory in rio de janeiro from january 2008-july 2012 . the subjects ages varied from two-56 years , but 46% of the isolates wer...
streptococcus pyogenes is responsible for a variety of infectious diseases and immunological complications . in this study , 91 isolates of s. pyogenes recovered from oropharynx secretions were submitted to antimicrobial susceptibility testing , emm typing and pulsed - field gel electrophoresis ( pfge ) analy...
acute retinal necrosis ( arn ) syndrome is clinically characterized by peripheral necrotizing retinitis , retinal arteritis , and a prominent inflammatory reaction in the vitreous and anterior chamber.1 the pathogenesis of arn is presumed to be associated with herpes virus infection , varicella - zoster virus ( vzv ) ,...
backgroundto report a case of simultaneous detection of cytomegalovirus ( cmv ) in acute retinal necrosis ( arn ) due to varicella - zoster virus ( vzv ) in an immunocompetent adult.methodsa 65-year - old healthy woman presented with necrotizing retinitis . vitreous , tears , saliva , and swabs of the auricular and f...
video assisted thoracic surgery ( vats ) was introduced in the early 1990s [ 1 , 2 ] and is now widely considered to be the gold standard for suspected malignant lung nodule resection . the technique might reduce patient discomfort , complications , the need for higher level of care , hospital stay , and cost compare...
aim . we describe our experience of a simple , safe , and reproducible technique for lung nodule marking prethoracoscopic metastasectomy . thoracoscopic lung nodule resection reduces patient discomfort , complications , higher level of care , hospital stay , and cost ; however , small deeply placed lung nodules are d...
various investigations have focused on it due to its biological activities , high tendency to recur and different growth mechanisms in comparison with other cystic lesions . many studies have been conducted on cell - cycle associated proteins such as antiapoptotic markers ( tp53 , bcl-2 ) and cell proliferation marke...
background : keratocystic odontogenic tumor ( kcot ) is a developmental odontogenic cyst on which various investigations have been focused due to its biological activities , high tendency to recur and different growth mechanisms in comparison with other cystic lesions . previous studies have shown different biologica...
. the natural history of this disease entity has not been well established , but it has been postulated that the prognosis is generally good . in contrast to carcinoid tumors arising in the jejunum and ileum , the clinical and laboratory findings of carcinoid syndrome are absent in patients with a carcinoid tumor of ...
here , a case of a patient with incidental finding of a carcinoid tumor of the ampulla of vater , who was treated with endoscopic snare papillectomy , is reported . a 62-year - old male was admitted to our hospital due to a carcinoid tumor of the ampulla of vater , which was found during follow - up endoscopy after a...
modern cataract surgery is entering the era of refractive surgery , allowing people not only to be able to see but also to be able to see clearly at all distances . it is well known that the presence of astigmatism in the eye in which the multifocal intraocular lens ( iol ) is implanted can affect vision [ 1 , 2 ] . ...
a child suffering from traumatic cataract and corneal astigmatism of 2.14 d had a phacoemulsification operation and implantation of a restor toric intraocular lens ( iol ) to correct the astigmatism . the primary outcome measurements were the uncorrected distance visual acuity ( udva ) , uncorrected near vision at 40...
cervical carcinoma is the second most common cause of cancer - related deaths in women worldwide , with a global annual incidence of approximately 470,000 new cases and an estimated 233,000 deaths per year . management for early cervical cancers generally involves radical abdominal hysterectomy and radiotherapy , wit...
summarybackgroundaldh1 has been shown to play a role in the early differentiation of stem cells in some human malignancies . whether cancer stem cells occur in aldh1-associated cervical cancer is not known.material/methodswe tested the hypothesis that cervical carcinomas contain subpopulations of cells that express a...
a descriptive cross - sectional study was conducted from january 28 , 2013 to february 8 , 2013 in burka jato kebele , nekemte town , east wollega zone , west ethiopia , 330 km away from addis ababa , capital of ethiopia . sample interval was determined by dividing the total number of households by sample size and se...
background : traditional medicine ( tm ) has maintained its popularity in all regions of the developing world . even though , the wide acceptance of tm is a well - established fact , its status in a population with access to modern health is not well clear in the whole country . this study was carried out to assess...
consecutive patients > 2 years of age with fever ( > 38c tympanic ) who came to teaching hospital karapitiya were enrolled ( 8) . standardized epidemiologic and clinical data and blood were obtained during acute illness and 24 weeks later . during the study ( march october 2007 ) , the atmospheric temperature ranged...
we studied rickettsioses in southern sri lanka . of 883 febrile patients with paired serum samples , 156 ( 17.7% ) had acute rickettsioses ; rickettsioses were unsuspected at presentation . additionally , 342 ( 38.7% ) had exposure to spotted fever and/or typhus group rickettsioses and 121 ( 13.7% ) scrub typhus . ...
neoplasms that arise in salivary gland are rare and yet they represent a wide variety of benign and malignant histological subtypes . salivary gland neoplasms make up 1% of all head and neck tumors . among these , 80% arise in parotid gland , 10 - 15% in submandibular gland and the remainder in sublingual and minor...
oncocytic carcinoma is an extremely rare neoplasm of the salivary gland , with only a few cases reported in literature till date . we report the occurrence of this rare lesion in lip in a 43-year - old female presenting with a progressively increasing swelling for which excision was done . fine needle aspiration wa...
fasciola hepatica is the causative agent of liver fluke disease in sheep and cattle and has worldwide distribution especially in the temperate areas ( 1 - 4 ) . furthermore , fasciolosis is a foodborne zoonotic disease in rural areas of developing countries such as bolivia , peru , equador , egypt and iran ( 5 ) . ...
backgroundfasciola hepatica is one of the most important helminthes parasites and triclabendazole ( tcbz ) is routinely used for treatment of infected people and animals . secreted protease enzymes by the f. hepatica plays a critical role in the invasion , migration , nutrition and the survival of parasite and are ke...
environmental , genetic , and immunologic factors are involved in the pathogenesis of celiac disease ( cd ) , a chronic inflammatory disease characterised by flattened villi on the small bowel mucosa . cd is induced by the ingestion of cereals containing proline - rich and glutamine - rich proteins ( such as wheat , ...
paraoxonase-1 ( pon1 ) plays an antioxidant and anti - inflammatory role . aim of the study was to investigate the alteration of paraoxonase-1 activity in celiac disease ( cd ) , an intestinal disorder characterized by toxic injury exerted by gluten peptides . activities of pon1 , levels of biochemical markers of l...
cardiovascular diseases have become a ubiquitous cause of morbidity and a leading contributor to mortality in most countries and this fact is well documented in developed countries . it is projected that the circulatory system disease in india would rise by 103% in man and 90% in women during the period 1985 to 2015 ...
objective : to determine the in vitro free radical scavenging property and in vivo diuretic effect of triglize , a marketed polyherbal formulation in experimental models.materials and methods : the aqueous extract of polyherbal formulation ( phf ) triglize was used for the experiment . the free radical scavenging pro...
pain is a common and disabling symptom in persons with multiple sclerosis ( ms ) , with a prevalence ranging widely between 29% and 86% [ 13 ] . several different pain conditions are associated with ms and may be defined by location , by presumed mechanism , and by duration , ranging from paroxysmal to chronic . rest...
backgroundchronic pain is common in persons with multiple sclerosis ( ms ) , but the co - morbidity of fibromyalgia ( fm ) has yet to be investigated in ms . objectives of the study were to evaluate , among the various types of chronic pain , the frequency of fm in ms and its impact on ms patients health - related qu...
the diagnosis is usually made by demonstration of antigen in the urine , serum , relevant body fluids or pus and by fungal culture . herein we are presenting a rare case of genitourinary histoplasmosis where the diagnostic dilemma was resolved by fungal culture of prostatic abscess and histopathological examination o...
genitourinary histoplasmosis is very rare and to our knowledge only four cases of epididymal histoplasmosis and nine cases of prostatic histoplasmosis have been reported in literature . we hereby report a case of a middle - aged male , who presented three years after renal transplant , with complaints of fever , pain...
simulated datasets with known underlying disease mechanisms have been widely used to develop efficient statistical methods for deciphering the complex interplay between the genetic and environmental factors responsible for complex human diseases , such as hypertension , diabetes and cancer [ 1 - 3 ] . although genetic ...
because little is currently known about how genes interact with environmental factors in human diseases , and because of the large number of possible interactions between and within genetic and environmental factors , it is difficult to simulate samples for a disease caused by multiple interacting genetic and environme...
although many effective chemically synthesized drugs exist for the treatment of hypertension , there is a great deal of interest in using natural plant extracts to attenuate the increased blood pressure levels in hypertensive patients and to prevent the cardiovascular disorders associated with this disease [ 13 ] . t...
the effect of long - term intake of different doses ( 20 , 40 , and 60 mg / kg / day ) of a fraxinus excelsior l. seed extract ( fese ) on spontaneously hypertensive rats ( shr ) was evaluated . water was used as control and captopril ( 50 mg / kg / day ) was used as positive control . systolic blood pressure , b...
bedding can be effectively used as a floor covering to absorb moisture and provide a soft surface . some studies have used the preference test to investigate the bedding preference in horses and ponies [ 3 , 4 , 6 ] . these studies have reported that the animals preferred straw over shavings and paper as the ...
the objective of this study was to investigate the effect of straw , sawdust , coconut husk ( husk ) , and coconut fiber ( fiber ) on the welfare of stable horses by observing their resting behavior . twenty horses with ages ranging from 3 to 21 years were used at the equine research institute of the japan raci...
obesity is associated with infertility and an increased risk of preterm birth in pregnant women . women who are unable to achieve this weight loss with conservative therapies can decide to undergo bariatric surgery , which has shown to improve fertility up to 58% and to reduce adverse maternal and neonatal outcomes [...
women desiring pregnancy might fail to conceive due to their obesity . bariatric surgery has shown to reduce this infertility up to 58% and is therefore considered a successful strategy for morbidly obese infertile women . nevertheless , when pregnancy has succeeded , surgery - related complications might occur.ban...
cutaneous paraneoplastic syndromes include acanthosis nigricans , the sign of leser - trlat , eruptive acrochordons , acquired ichthyosis , erythroderma , palmoplantar hyperkeratosis , acquired hypertrichosis lanuginosa , erythema gyratum repens , necrolytic migratory erythema , bazex 's syndrome and dermatomyositis . ...
we report the case of a 79-year - old caucasian man , who developed numerous pruritic seborrheic keratoses on his chest and back within one year . an underlying malignant disease was suspected . upper and lower endoscopies were performed and the patient was diagnosed with adenocarcinoma of the ascending colon . w...
atherosclerotic renal artery stenosis ( ras ) is an important and frequently unrecognized contributor to refractory hypertension ( htn ) , ischemic nephropathy , and cardiac destabilization syndromes ( unstable angina , flash pulmonary edema , and decompensated heart failure).15 atherosclerotic ras is a progressive dis...
aims : we evaluated the relationship between distribution of lesions in coronary tree and atherosclerotic renal artery stenosis ( ras).methods and results : data collected prospectively on 500 consecutive patients who underwent simultaneous renal angiography following coronary angiography . overall prevalence of ras ...
a 12-year - old female visited the hospital with the chief complaint of an abnormal finding on a simple chest x - ray . a discontinuity of the diaphragm was observed in the retrosternal portion by chest ct and mesenteric fat was herniated through this discontinuity ( fig . the lack of an intestinal hernia was confi...
a 12-year - old female presented with the abnormal findings on the chest pa . the chest ct revealed a retrosternal defect of the diaphragm and a fatty opacity in the pleural cavity , resulting in a diagnosis of morgagni hernia . it was decided to undergo a laparoscopic surgery . the retrosternal defect of the dia...
the clinical and radiographic findings of traumatic dental injury reveal a loss of tooth structure with pulp exposure , which is commonly referred to in dental literature as complicated crown fracture . the majority of these injuries occur in recently erupted or young permanent teeth that have immature roots . the ...
this case report describes the partial pulpotomy treatment of complicated crown fractures of two cases by using white mineral trioxide aggregate ( wmta ) with long - term follow - up . in the cases presented here , to injured incisor teeth were open apices and the pulp exposure site was large , so it was decided to p...
psoriasis is a chronic , recurrent , inflammatory disorder of the skin affecting approximately 2% of the world 's population . psoriasis vulgaris ( psv ) is the most common type of psoriasis , which manifests as well - demarcated , scaly patches on the skin . psoriasis is considered severe if more than 10% of a pat...
background : few clinical trials have evaluated the efficacy and safety of tripterygium wilfordii hook f ( twhf ) compared with acitretin in psoriasis . we aimed to compare the efficacy and safety of twhf compared with acitretin in the treatment of moderate to severe psoriasis vulgaris.methods:adults with psoriasis a...
the liver is the most common , and often the only , site of distant metastases from colorectal cancer ( crc).1 hepatic resection is the only effective therapy for a subset of patients with crc metastatic to the liver , and is associated with 5-year survival rates ranging from 25 to 40%.25 from 60 to 65% of patients wil...
backgroundrecent data confirmed the importance of 18-fluoro-2-deoxy - d - glucose positron emission tomography ( fdg - pet ) in the selection of patients with colorectal hepatic metastases for surgery . neoadjuvant chemotherapy before hepatic resection in selected cases may improve outcome . the influence of chemot...
... the aim of oxygen therapy should be to increase the delivery of oxygen rather than to reach any arbitrary concentration in the arterial blood . is administration of oxygen , the most widely prescribed drug in the formulary , free of risks to nonhypoxemic patients with regional ischemia ? hyperoxia marginally in...
supplementary oxygen is routinely administered to patients , even those with adequate oxygen saturations , in the belief that it increases oxygen delivery . but oxygen delivery depends not just on arterial oxygen content but also on perfusion . it is not widely recognized that hyperoxia causes vasoconstriction , ei...
rotavirus gastroenteritis ( rvge ) is the most common cause of severe diarrhea among infants and young children aged < 5 years in developed and developing countries.[24 ] symptoms can range from mild watery diarrhea to severe diarrhea with forceful vomiting , abdominal distress , and fever , which can lead to serious c...
the most common cause of severe diarrhea in infants and young children is rotavirus gastroenteritis ( rvge ) , which is associated with significant morbidity , healthcare resource use , and direct and indirect costs in industrialized nations . the monovalent rotavirus vaccine rix4414 ( rotarix ) is administered as a ...
life - time prevalence of acute pain , in particular headache , is assumed to be nearly 100% . this means that , i.e. almost every individual will suffer from some kind of pain ( e.g. headache ) during their lifetime . life - time headache prevalence alone is 66% worldwide , in adults in europe it is 80% for tensio...
there are no reliable data at present on use of analgesics in various countries . we compared per - capita consumption in nine different countries during the period 19862005 . the per - capita consumption was calculated on the basis of the sales figures of distributors to pharmacies and direct purchases by pharmace...
it is effective in attaining various pharmacological actions like deepana , pachana , shamana , shodhana , tarpana etc . , when prepared according to classical guidelines , used in appropriate concentrations and clinical conditions . manjishtadi kashayam ( mk ) , rasna erandadi kashayam ( rek ) , sahacharadhi kasha...
background : the five kashayams ( kwaths - decoctions ) manjishtadi kashayam ( mk ) , rasna erandadi kashayam ( rek ) , sahacharadhi kashayam ( sk ) , maharasnadi ( or rasna dwiguna bhagam ) kashayam ( mrk ) and dhanwantharam kashayam ( dk ) are widely used in the management of diseases manifested due to vitiation of v...
a 15-year - old boy was admitted to the emergency room with anterior chest pain , nonproductive cough , progressive dyspnea , and subcutaneous emphysema of the neck . all symptoms had occurred suddenly , although the night before and the morning of the acute respiratory distress he had experienced heavy breathi...
we describe the case of an adolescent who was admitted to the hospital because of sudden occurrence of chest pain , dyspnea and subcutaneous emphysema . on admission , physical examination revealed subcutaneous crepitations in the superior part of the rib cage , and auscultation of the chest showed widespread wheezin...
research in the invertebrate model drosophila melanogaster has driven the discovery of innate immunity , and has facilitated the understanding of various aspects of blood cell development . drosophila hematopoiesis can be divided into the lineage of embryonic / larval hemocytes , which originate in the embryo and exp...
in vertebrates , hematopoiesis is regulated by inductive microenvironments ( niches ) . likewise , in the invertebrate model organism drosophila melanogaster , inductive microenvironments known as larval hematopoietic pockets ( hps ) have been identified as anatomical sites for the development and regulation of bloo...
chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids ( clippers ) is an inflammatory disorder in the central nervous system ( cns ) with distinct clinical , radiological , and pathological features . although the radiological lesions were reported to be located predominantly i...
abstractbackground : chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids ( clippers ) is an inflammatory disorder in the central nervous system ( cns ) with distinct clinical , radiological , and pathological features . the pathophysiology of clippers still remains unclear an...
clozapine has been known to cause haematological side effects like agranulocytosis , neutropenia , leucocytosis , eosinophilia and thrombocytopenia . although some data is available with regard to leucopenia , data for thrombocytopenia is limited . in this report we present the case of a patient who developed throm...
although agranulocytosis as a side effect of clozapine is well known , there is scarcity of data with regard to thrombocytopenia associated with clozapine . in this report we describe a case of clozapine induced thrombocytopenia and review the existing literature . a 22 year old female patient developed thrombocytope...
alzheimer s disease ( ad ) is the leading cause of dementia worldwide and represents one of the most serious health issues for the elderly . an estimated 5.4 million americans have ad , and this number is expected to triple in 2050 due to lack of medical breakthroughs to stop , prevent , or slow the disease.1 over th...
tumor necrosis factor ( tnf- ) plays a central role in the pathophysiology of alzheimer s disease ( ad ) . food and drug administration approved biologic tnf- inhibitors are thus a potential treatment for ad , but they do not cross the blood - brain barrier . in this short review , we discuss the involvement of t...
paradoxical enlargement of lymph nodes in tuberculosis is well established in the early phase of treatment.[13 ] this is more common in hiv co - infection . mediastinal lymphadenopathy resulting in recurrent laryngeal nerve palsy , pulmonary artery occlusion and superior vena caval obstruction has been described . ...
we present here a case of bronchial obstruction secondary to late paradoxical reactive enlargement and erosion by mediastinal lymph nodes into the left main bronchus in a 26-year - old woman with tuberculosis lymphadenitis . bronchial obstruction due to paradoxical reactions , especially in the late phase of treatmen...
here we report the preparation of poly(oligonucleotide ) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft - through polymerization . we describe the polymerization of pna - norbornyl monomers to yield poly - pna ( poly(peptide nucleic acid ) ) via ring - opening metathesis ...
many potential human health effects have been hypothesized to result either directly or indirectly from global climate change . changes in the prevalence and spread of infectious diseases are some of the most widely cited potential effects of climate change , and could have significant consequences for human health a...
contact investigation around tuberculosis ( tb ) patients is considered the most effective strategy in low prevalence settings for early detection of infection and disease , and for prevention of secondary tb cases . the aims of contact investigation are primarily to find and treat secondary active tb disease to disr...
contact investigations around tuberculosis patients enable early detection of infection and disease , and prevention of secondary tuberculosis cases . we aim to identify risk factors for m. tuberculosis transmission to contacts of tuberculosis patients , based on unique data from routine contact investigations by the...
adolescence is a vulnerable period for the development of obesity and also appears to be a critical period for establishing risk factors for some chronic diseases in adulthood . available statistics indicate that an alarming proportion of people in most arab countries suffer from obesity . studies have revealed tha...
objective . the aim of this study was to find out the prevalence of overweight and obesity among adolescents in seven arab countries using similar reference standard . methods . a school - based cross - sectional study was carried out in seven cities in arab countries , namely , algeria , jordan , kuwait , libya , ...
various types of dermatological manifestations have been reported due to hepatitis c virus ( hcv ) infection and antihcv therapy . some of them have been described during ifn - based therapies . peg - ifn--2a / rbv combination is used as the international standard of treatment for hcv infection for a long time . th...
introduction : various types of dermatological manifestations have been reported due to hepatitis c virus ( hcv ) infection and antihcv therapy . some of them have been described during ifn - based therapies . peg - ifn--2a / rbv combination is used as the international standard of treatment for hcv infection for a l...
chromium is an environmentally significant human carcinogen with complicated metabolism and an unknown mechanism of mutagenesis . chromium(vi ) is taken up by cells as the chromate anion and is reduced intracellularly via reactive intermediates to stable cr(iii ) species . chromium(iii ) forms tight complexes with ...
patients with higher levels of postoperative pain tend to have more postoperative complications , longer hospital stays leading to higher medical costs , and lower levels of patient satisfaction . the purpose of this retrospective study was to test the hypothesis that patients undergoing open hepatic resection requir...
background and aims : postoperative pain can significantly affect surgical outcomes . as opioid metabolism is liver - dependent , any reduction in hepatic volume can lead to increased opioid concentrations in the blood . the hypothesis of this retrospective study was that patients undergoing open hepatic resection wo...
pilocytic astrocytomas ( pas ) , which are most common in children , are world heath organization grade i tumors with a good prognosis . this neoplasm can occur at all levels of the neuraxis but occurs most frequently in the cerebellum and the optic pathways2 ) . calcification in pas is not a common finding and is ...
pilocytic astrocytomas ( pas ) are world heath organization grade i tumors and are most common in children . pa calcification is not a common finding and has been reported more frequently in the optic nerve , hypothalamic / thalamus and superficially located cerebral tumors . we present a cerebellar pa in a 3-year ...
supplementary material is available for this article at 10.1007/s13659 - 011 - 0032 - 6 and is accessible for authorized users .
the reduction of geraniol to citronellol is the first step for the synthesis of natural phytol in the production of tocopherols and natural vitamin k. baker s yeast was used in the bioreduction described above as a whole - cell biocatalyst . however , the enzyme responsible for the reduction of geraniol to citronello...
the precise measurement of corneal power after myopic laser refractive surgery is still currently an issue under debate . several methods have been proposed during the last years which are classified as methods requiring historical clinical data and methods not requiring historical data . among those methods requirin...
purpose . to validate clinically a new method for estimating the corneal power ( pc ) using a variable keratometric index ( nkadj ) in eyes with previous laser refractive surgery . setting . university of alicante and medimar international hospital ( oftalmar ) , alicante , ( spain ) . design . retrospective case...
jaffe , lichestein , and portis first defined the criteria for diagnosing gct in 1940 to differentiate it from other giant cell containing lytic lesions of bones . giant cell tumor ( gct ) of the spine is a rare entity and has been known as a benign aggressive tumor in the literature . it has been known to affect m...
giant cell tumor ( gct ) is a benign aggressive tumor , which affects axial as well as a peripheral skeleton . it affects epiphysis of long bones and can result in pathological fractures . gct affects cervical spine rarely and has been known to affect almost all vertebra in the human body . it has a predilection ...
chest x - ray is one of the most widely used methods for population screening and patient evaluation in virtually all cardiac diseases.[14 ] the american college of cardiology / american heart association ( acc / aha ) and the european guidelines for the diagnosis and treatment of heart failure advocate looking for the...
objectives : the development of technologically advanced , expensive techniques has progressively reduced the value of chest x - ray in clinical practice for the assessment of left ventricular ( lv ) dilatation and dysfunction . although controversial data are reported on the role of this widely available technique i...
bone remodeling occurs throughout life via synthesis of bone matrix through the action of two major bone cells : osteoblasts and osteoclasts [ 1 - 3 ] . the proper functioning of these cells is necessary for the maintenance of bone mass as well as bone mineral density ( bmd ) . during old age and especially postmenop...
the ginseng plant ( panax ginseng meyer ) has a large number of active ingredients including steroidal saponins with a dammarane skeleton as well as protopanaxadiol and protopanaxatriol , commonly known as ginsenosides , which have antioxidant , anticancer , antidiabetic , anti - adipocyte , and sexual enhancing effect...
progression through the eukaryotic cell cycle is controlled by the sequential activation and inactivation of cyclin - dependent kinases ( cdks ) . the kinase activity of cdks is regulated by cyclin synthesis and destruction , phosphorylation of the kinase and cyclin , binding to inhibitory polypeptides and subcellula...
multiple a- and b - type cyclins have been identified in animals , but their study is complicated by varying degrees of functional redundancy . a single functional a - type cyclin gene was found in invertebrates and two were found in vertebrates . the number and relationship of b - type cyclins varies between caeno...
amniocentesis for prenatal karyotyping is today the most frequently performed invasive intrauterine procedure ( eisenberg and wapner , 2002 ) , but still carries a procedure related risk for amniotic fluid leakage estimated to be approximately 1 - 2% ( reece , 1997 ; tabor et al . , 1986 ) . postprocedural amniotic f...
objectives : to experimentally compare the standard 22 g spinal needle with a newer 23 g needle with specific ultrasound visualisation tip ( cook echotip , spencer , indiana , usa ) in the setting of ultrasound - guided invasive intrauterine procedures.materials and methods : we first determined the size of the defects...
atlantoaxial instability can result from congenital malformations , systemic inflammatory conditions , neoplasms , and spinal trauma . c1c2 stabilization can be challenging due to the complex anatomy of the c1 and c2 vertebrae . the proximity of neurovascular structures , the variability of vertebral artery anatomy...
study design case series of seven patients . objective c2 stabilization can be challenging due to the complex anatomy of the upper cervical vertebrae . we describe seven cases of c1c2 fusion using intraoperative navigation to aid in the screw placement at the atlantoaxial ( c1c2 ) junction . methods between ...
conservative therapy ranges from parenteral nutrition , gastric drainage , and antibiotics to interventional techniques such as implantation of covered stents and closure with clips . esophageal stenting or clipping of esophageal leaks often has to be combined with simultaneous external drainage 1 2 . endoscopic ...
background and study aims : endoscopic vacuum therapy ( evt ) has been reported as a novel treatment option for esophageal leakage . we present our results in the treatment of iatrogenic perforation with evt in a case series of 10 patients . patients and methods : an open pore polyurethane drainage was placed eithe...
enteric fever is endemic in developing countries such as india where sanitary conditions and potable water is not accessible to all . patients typically present at the end of the first week after the onset of symptoms with fever , influenza - like symptoms with a dull frontal headache , malaise , etc . , but with few...
focal infection is an uncommon complication of salmonella septicemia , particularly in immunocompetent patients . the localization of salmonella infection to breast tissue is regarded as a rare event . we report a case of bilateral breast abscesses due to salmonella enterica serotype typhi in a nonlactating female ...
patients with cancer have several risk factors for wernicke encephalopathy , including the use of chemotherapeutic agents , nutritional imbalance , performance of bypass surgery , and disease progression due to fast - growing tumor cells . the classical symptoms of wernicke encephalopathy are global confusion , ataxi...
wernicke encephalopathy is a disease that constitutes a medical emergency , but one that can be reversed with thiamine repletion if it is recognized early . patients with cancer have a high risk of wernicke encephalopathy because of malnutrition , the use of chemotherapeutic agents , and disease progression . korsa...