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this paper is the report on and balance of some thirty years of transcultural research on mood disorders .
the aim of our work was to produce a hypothesis bringing together the different ways in which discomfort manifests itself , with special emphasis on discomfort viewed through mood symptoms .
our goal was to se... | introduction : the objective of this paper is to see if behaviours defined as pathological and maladjusted in certain contexts may produce adaptive effects in other contexts , especially if they occur in attenuated form .
interactions between environment and behaviour are studied from an evolutionary standpoint in an... |
primary angiitis of the central nervous system ( pacns ) was identified as a distinct clinical entity in adults in 1959 , and only recently now in children as a cause of childhood stroke .
the disease should be suspected in children presenting with newly acquired neurological or psychiatric deficits after exclusion o... | childhood primary angiitis of the central nervous system ( cpacns ) is a rare and a potentially fatal cause of childhood stroke .
the disease poses a diagnostic dilemma for the clinicians due to overlapping and varied clinical manifestations such as headache , focal acute neurological deficits , cognitive impairment ... |
over the last decades , health care systems have faced important challenges in dealing with pressures to increase the performance of the services they offer while the allocated resources to offer such care have remained stable or have decreased .
integration has been presented as an efficient solution to improve serv... | backgroundhaving a common vision among network stakeholders is an important ingredient to developing a performance evaluation process .
consensus methods may be a viable means to reconcile the perceptions of different stakeholders about the dimensions to include in a performance evaluation framework.objectivesto dete... |
this study was conducted during 14 months ( october 2014 to november 2015 ) on patients with ag ( n=39 ) and gc ( n=40 ) at two medical oncology and gastroenterology facilities in the northwestern region of algeria .
infection with h. pylori was confirmed by histopathology of biopsies sampled during diagnostic endosc... | backgroundinfection with helicobacter pylori is considered a potential risk of developing gastric cancer in association with contributing host genetic factor . il-1 and
il-1rn polymorphisms appear to maintain and promote helicobacter pylori infection and to stimulate neoplastic growth of the gastric mucosa.objective ... |
, this definition probably not only applies to different symptoms and hence deserves further classification [ 1 , 2 ] ( for example , the distinction between spontaneous and provoked confabulations ) but also appeals to a broader spectrum of disorders ( psychosis , delirium , korsakoff disease , stroke ) and to multipl... | we describe the case of a 75-year - old woman who manifested persistent confabulations after two consecutive strokes encompassing the area of the lenticulostriate arteries territory on both hemispheres .
findings reported on this rare clinical syndrome suggest that fantastic confabulations and delusional thoughts may... |
there are several harmful factors at work environment that causes fatigue , burnout , and early exhaustion of individuals , and lead to the waste of time and money .
manual material handling ( mmh ) tasks are one of the common occupational factors ( 1 ) . in most industries , and even in non - occupational settings ,... | background : low back pain caused by work , ranked the second after cardiovascular diseases , are among the most common reasons of patients referral to the physicians in iran .
this study aimed to determine the changes in back compressive force when measuring maximum acceptable weight of lift in iranian male students... |
during the seventeenth and eighteenth centuries , scurvy came to prominence as a disease of sailors and soldiers .
there was general agreement that it was caused by putrefaction of the humours , the corruption of which was often attributed to a diet of noxious foods or prolonged exposure to cold and damp . by the lat... | from the late eighteenth century , the ways in which scurvy was understood changed in consequence of the abandonment of humoral pathology and the adoption of a new causal framework informed by nervous physiology .
although there was some narrowing of the etiological framework around dietary deficiency in the wake of ... |
aggressive angiomyxoma ( aa ) is a rare benign soft tissue tumour usually affecting the pelvis and perineum of young women .
magnetic resonance imaging ( mri ) is crucial in the management of aa patients for its diagnostic contribution and for the preoperative assessment of the actual tumour extension . given the cur... | introductionaggressive angiomyxoma ( aa ) is a rare benign soft tissue tumour usually affecting the pelvis and perineum of young women .
magnetic resonance imaging ( mri ) is crucial in the management of aa patients for its diagnostic contribution and for the preoperative assessment of the actual tumour extension . g... |
the syndrome often presents in late middle life ; however , the incidence in the elderly has almost certainly been underestimated . in a recent pathologically
ascertained series of 100 cases , the mean age of onset was 60.3 years with a range of 4079 years ( hodges et al .
the features of the language disturbance... | semantic dementia ( sd ) is a unique syndrome in the frontotemporal lobar degeneration spectrum . typically presenting as a progressive , fluent anomic aphasia
, sd is the paradigmatic disorder of semantic memory with a characteristic anatomical profile of asymmetric , selective antero - inferior temporal lobe atroph... |
breast cancer is a heterogeneous group of diseases which deviate from each other in natural history , morphology , molecular phenotype , clinical and radiological manifestations , and prognosis .
prognostic parameters are essential for predicting the outcome and response to therapy in individual cases .
the long li... | breast cancer subgross morphological parameters ( disease extent , lesion distribution , and tumor size ) provide significant prognostic information and guide therapeutic decisions .
modern multimodality radiological imaging can determine these parameters with increasing accuracy in most patients .
large - format h... |
slx4 is a scaffold protein that binds to three dna repair endonucleases , mus81-eme1 , xpf - ercc1 , and slx1 ( andersen et al . , 2009 ,
, 2009 , muoz et al . , 2009 , saito et al . , 2009 ,
the slx4 complex is required for the efficient repair of dna interstrand crosslinks ( icls ) , ( fekairi et al . , 2009 ... | summaryslx4 , a scaffold for structure - specific dna repair nucleases , is important for several types of dna repair .
many repair proteins bind to sites of dna damage , resulting in subnuclear
foci ,
but slx4 forms foci in human cells even without dna damage . using several approaches ,
we show that most , bu... |
crotoxin ( ctx ) is the main toxic component of the venom of the south american rattlesnake , crotalus durissus terrificus [ 1 , 2 ] .
the toxin is a heterodimeric complex consisting of basic and toxic phospholipase a2 and an acidic , nontoxic , and nonenzymatic component named crotapotin .
in addition to its toxic... | we investigated the effects of crotoxin ( ctx ) , the main toxin of south american rattlesnake ( crotalus durissus terrificus ) venom , on walker 256 tumor growth , the pain symptoms associated ( hyperalgesia and allodynia ) , and participation of endogenous lipoxin a4 .
treatment with ctx ( s.c . ) , daily , for 5 d... |
postmortem dismemberment cases , sometimes referred to in the media as corpse mutilation , abuse of corpse or criminal dismemberment , present a challenge to investigators attempting to identify the tool used in the dismemberment .
if multiple tools are recovered , examinations could be conducted to link or eliminate... | saw marks on bone have been routinely reported in dismemberment cases .
when saw blade teeth contact bone and the bone is not completely sawed into two parts , bone fragments are removed forming a channel or kerf . therefore , kerf width can approximate the thickness of the saw blade .
the purpose of this study is ... |
despite advancements in airway management , treatment of fractures in the maxillofacial region under general anesthesia remains a unique anesthetic challenge .
we reviewed the pattern of airway management in patients with maxillofacial fractures and assessed those challenges associated with the different airway manag... | background : despite advancements in airway management , treatment of fractures in the maxillofacial region under general anesthesia remains a unique anesthetic challenge .
we reviewed the pattern of airway management in patients with maxillofacial fractures and assessed those challenges associated with the different... |
certain colorectal conditions , such as ulcerative colitis and diffuse polyposis of the colon and rectum , and congenital intestinal abnormalities , such as total colonic aganglionosis , require a proctocolectomy and some type of intestinal restoration 1 .
although these procedures are technically demanding for surge... | key clinical messagewe present a pediatric case of medically unmanageable juvenile colonic polyposis , initially treated with subtotal colectomy and an ileostomy followed by a proctectomy , ileal - j - pouch and serial transverse enteroplasties ( step ) of the distal ileum . the step procedure in an adequate length was... |
children between 3 and 10 years of age with type 1 diabetes for at least 6 months and healthy controls subjects were recruited .
all procedures were approved by the institutional review board and all parents or guardians signed informed consents . children over 7 years of age signed assents ( clinicaltrials.gov study... | objectiveto detect clinical correlates of cognitive abilities and white matter ( wm ) microstructural changes using diffusion tensor imaging ( dti ) in young children with type 1 diabetes.research design and methodschildren , ages 3 to < 10 years , with type 1 diabetes ( n = 22 ) and age- and sex - matched healthy cont... |
diseases that were prevalent are now increasingly rare because of the widespread use of vaccines .
next to clean water , no single intervention has had such an overwhelming effect on reducing mortality from childhood diseases as the use of vaccines .
the smallpox vaccine has eradicated a disease that had a 30 % fa... | the vast majority of human pathogens colonize and invade at the mucosal surfaces . preventing infection at these sites via mucosally active vaccines
is a promising and rational approach for vaccine development .
however , it is only recently that the stimulation of local immunity at the mucosal surfaces has become ... |
carcinoma of the prostate is the most common malignancy in men with increased incidence rates owing to the population ageing and the improvement of diagnostic procedures .
the early detection of the bone metastases is of value in making decision regarding the treatment plan , which may vary extremely according to the... | 18f - fech - pet / ct has been proved to be an imaging agent for prostate carcinoma . however , its role in detecting the bone metastases is still blurred owing to the lack of related studies .
the purpose of our study was to assess the efficacy of pet with 18f - ethylcholine in assessing the bone status and to compa... |
actinomycosis , a rare chronic granulomatous infection induced by actinomyces species , colonizes the mouth , colon , and vagina ( 1 ) . mucosal disruption may lead to infection at virtually any anatomic site of immunocompromised body , such as head and neck , chest , abdomen , and pelvis region . in literature reports... | here we report a case of 41-year - old man with a soft tissue density mass at right upper lung and palpable abscesses at right upper backside and right wrist .
18f - fluorodeoxyglucose positron emission tomography / computed tomography demonstrated a 7.8 5.0 cm mass with soft - tissue density in the upper lobe of th... |
muscle contraction is due to cyclic interactions between
myosin ii
motor proteins and actin filaments powered by the cellular fuel adenosine-5-triphosphate
( atp ) . in in vitro assays one uses surface adsorbed
myosin motors , or preferentially myosin motor fragments such as heavy
meromyosin ( hmm ) , to prop... | semiconductor nanowire arrays offer
significant potential for biosensing
applications with optical read - out due to their high surface area
and due to the unique optical properties of one - dimensional materials .
a challenge for optical read - out of analyte - binding to the nanowires
is the need to efficie... |
this study was conducted in a school center that had been the focus of intense public concern over 2 years because of suspected mold and health problems .
because several attempts to find solutions to the problem within the community were not satisfactory , outside specialists were needed for support in solving the p... | |
poly(vinylidene fluoride )
( pvdf ) is a widely studied and used polymer ,
especially for industrial application due to its excellent chemical ,
mechanical , and uv stability properties .
pvdf membranes have been
extensively used in ultrafiltration ( uf ) and microfiltration ( mf )
applications for separati... | poly(vinylidene fluoride ) ( pvdf )
was modified by chemical treatments
in order to create active double bonds to obtain covalent grafting
of poly(acrylic acid ) ( paa ) on membrane .
the attenuated total reflectance
fourier transform infrared ( atr - ftir ) spectrum confirms the formation
of conjugated c =... |
the first - line regimen for the treatment of helicobacter pylori ( h. pylori ) infection in japan is triple therapy with a proton pump inhibitor ( ppi ) , amoxicillin and clarithromycin [ 1 , 2 ] .
failure of eradication of h. pylori infection with this first - line therapy has been reported in approximately 20% of ... | currently , a standard third - line therapy for helicobacter pylori ( h. pylori ) eradication remains to be established .
quinolones show good oral absorption , no major side effects , and marked activity against h. pylori .
several authors have studied quinolone - based third - line therapy and reported encouragin... |
diabetes mellitus ( dm ) is a popular lifelong metabolic disease , and probably will remain the most frequent cause of death in the following decades .
diabetes as a concerned epidemic problem is increasing all over the world.[210 ] statistical estimations show that the number of diabetic individuals will be 65% of t... | objective : to investigate the role of dietary patterns in prevention and management of type 2 diabetes mellitus.materials and methods : a systematic review of databases which were published in isi , cochrane central register of controlled trials databases , pubmed , iran medex , and magiran was performed .
diabetes ... |
tissues are diverse not only in their structure and function but also in the dynamics of their constituent cells ( leblond & walker , 1956 ) . sc turnover rates in adult mouse lineages vary by orders of magnitude ( fig 1 ) .
epithelial and male germ scs cycle rapidly , while in tissues such as liver , kidney and mus... | abstractadult organisms have to adapt to survive , and the same is true for their tissues . rates and types of cell production
must be rapidly and reversibly adjusted to meet tissue demands in response to both local and systemic challenges .
recent work reveals how stem cell ( sc ) populations meet these requiremen... |
diseases of the heart continue to be the leading cause of death in the united states [ 1 , 2 ] and accounted for 24.6% of all deaths in 2009 , down only 1.4% from 2006 despite several national campaigns and research strategies to reduce mortality [ 1 , 2 ] .
african americans have poorer health outcomes compared to t... | findings from previous research linking sedentary time with cardiometabolic risk factors and body composition are inconsistent , and few studies address population groups most vulnerable to these compromising conditions .
the purpose of this paper was to investigate the relationship of sitting time to cardiometabolic... |
for efficacy studies , up to 3 female horses at a time were housed in single pens under bsl-4 conditions meeting the victorian bureau of animal welfare code of practice for the welfare of horses ( www.dpi.vic.gov.au/agriculture/about-agriculture/legislation-regulation/animal-welfare-legislation/codes-of-practice-animal... | in recent years , the emergence of several highly pathogenic zoonotic diseases in humans has led to a renewed emphasis on the interconnectedness of human , animal , and environmental health , otherwise known as one health .
for example , hendra virus ( hev ) , a zoonotic paramyxovirus , was discovered in 1994 , and s... |
in vivo studies using the animals provide invaluable information about various disease processes and help in development of treatment strategies . virtually every medical achievement in the twentieth century relied on the use of animals in some way.1 the institute for laboratory animal research of the u.s
. national ... | in vivo studies using the animals are helpful in developing the treatment strategies as they are important link between the successful in vitro testing and safe human use .
various research projects in the field of fixation of fractures , development of newer biomaterials , chemotherapeutic drugs , use of stem cells ... |
these tumors are rarely reported in infants . these lesions present as slowly progressive masses that can either compress to the adjacent vital structures or interfere with normal physiology .
we report a case of giant , solitary nf presenting as a progressive mass in parotid region in an infant and review the releva... | solitary neurofibroma is a rare tumor of the head and neck region .
it is more common in viscera , where it is associated with features of nf1 .
it occurs most often between the third and fourth decade .
these lesions are extremely rare in infants .
we report a case of giant , solitary neurofibroma presenting a... |
advances in our understanding of the genetic alterations underlying clear cell renal cell carcinoma ( rcc ) has led to a proliferation of clinically active agents for this disease , and since 2005 , a total of seven agents ( sorafenib , sunitinib , temsirolimus , bevacizumab , everolimus , pazopanib , and axitinib ) ha... | chromophobe kidney cancer accounts for approximately 5% of cases of renal cell carcinoma ( rcc ) .
while the genetics of clear cell rcc has been a major focus of research , little is known about the biology of chromophobe tumors .
there is ample preclinical rationale for the use of targeted therapy in clear cell tu... |
silver is a naturally occurring element with various physical properties , such as high thermal and electrical conductivity , ductility , hardness , malleability , and even antimicrobial ability .
silver was known and used by ancient people as early as 4000 bc , along with gold and copper.1 silver now has a wide vari... | this case report describes the clinical , autofluorescence , and optical coherent tomography findings in a patient with panocular argyrosis secondary to chronic intake of diluted silver nitrate salts in his water supply .
an 86-year - old caucasian male with a distinctive gray - bluish hue of the skin presented to ou... |
schwannomas are infrequent tumors originating from the neural crest cells and usually interpreted as slow - growing benign nerve sheath tumors [ 1 , 2 ] .
visceral sites of this tumor include the gastrointestinal tract , liver , pancreas , kidney , brain , heart and retroperitoneum .
retroperitoneal schwannomas acc... | adrenal schwannoma is an extremely uncommon cause of incidentaloma .
it originates from neural sheath schwann cells of the adrenal gland .
we report the case of a left adrenal schwannoma incidentally discovered in a 32-year - old woman during examination of bloated feeling and stomach ache .
the patient was incid... |
reports from the world health organization ( who ) reveal that 17.6 million persons contracted whooping cough in 2003 resulting in 279000 deaths ; however , some authorities estimate the real figures of cases with pertussis to be around 50 million with 90% living in developing countries . according to the report of who... | background : it seems that the incidence of pertussis - like illnesses is considerably increasing despite the wide coverage of immunization with the whole cell pertussis vaccine .
we aimed to investigate the occurrence of pertussis in vaccinated children by measuring anti - pertussis antibodies .
methods : in this ... |
pilar cysts are common , and benign lesions and malignant transformation in them is extremely rare .
trichilemmal cyst or pilar cyst is defined as a cyst containing keratin and its breakdown products .
it is usually situated on the scalp with a wall resembling external hair root sheath .
it is seen mainly in the ... | trichilemmal cyst or pilar cyst is defined as a cyst containing keratin and its breakdown products .
it is usually situated on the scalp with a wall resembling external hair root sheath . in this case report
we present a 55-year - old man with multiple giant pilar cysts that were distributed over the whole body sin... |
gastrointestinal stromal tumors ( gists ) , which arise primarily in the gut wall , are most commonly mesenchymal neoplasms closely related to the interstitial cells of cajal .
gists typically carry gain - of - function mutations in genes encoding the kit receptor tyrosine kinase ( cd117 ) or platelet - derived growt... | we report the case of a 56-year - old woman who had a gastrointestinal stromal tumor ( gist ) of the stomach .
she was admitted to our hospital for epigastric pain , nausea , and severe acute anemia ( hemoglobin level 4.3 g / dl ) .
esophagogastroduodenoscopy revealed a narrow stalk - like based , hemorrhagic and u... |
for this cross - sectional study , we recruited men with type 2 diabetes ( with and without cna ) , and attempted to age - match them with healthy control subjects .
inclusion criteria for the diabetic participants ( with and without cna ) included ambulatory men aged between 40 and 80 years with established type 2 d... | objectivethis study investigated the relationship between circulating soluble receptor for advanced glycation end products ( srage ) and parameters of bone health in patients with charcot neuroarthropathy ( cna).research design and methodseighty men ( aged 55.3 9.0 years ) , including 30 healthy control subjects , 30 ... |
study area - blood and serum collections were carried out during four
expeditions , three of which were conducted in the rainy season , while one was carried
out in the dry season .
six riverside communities along the border of ac and am were
studied : mapinguari ( 0924'08"s 6808'51.6"w ) and andara ( 0917'29.8... | mansonella ozzardi infections are common in the riverside
communities along the solimes , negro and purus rivers in the state of amazonas ( am ) .
however , little is known about the presence of this parasite in communities located
in regions bordering am and the state of acre . the prevalence rate of m.
ozzard... |
to identify risk variants for childhood acute lymphoblastic leukemia ( all ) we conducted a genome - wide association study of 2 case - control series , analyzing the genotypes of 291,423 tagging snp genotypes in a total of 907 all cases and 2,398 controls .
we identified risk loci for all at 7p12.2 ( ikzf1 , rs41326... | |
it is a common tumor of male paratesticular tissues ( epididymis , tunica or spermatic cord ) and has also been described in females ( uterus , fallopian tube , ovary and paraovarian tissues ) .
the majority of these tumors are asymptomatic and presents as a mass in the genital area , which is worrisome to both patie... | adenomatoid tumor is a benign mesothelial neoplasm of the paratesticular region in males but can also occur in female genital tracts .
the epididymis is the most common site of involvement and constitutes 32% of paratesticular neoplasms.we diagnosed a case of adenomatoid tumor on cytopathology in 24 years old male , ... |
appalachia is a region of over 530,000 square kilometers in the eastern united states of america that roughly corresponds to the area surrounding the appalachian mountains .
it is largely rural and has been geographically isolated in the past because of mountainous terrain , as well as transportation systems that hav... | background .
chronic poor oral health has a high prevalence in appalachia , a large region in the eastern usa .
the center for oral health research in appalachia ( cohra ) has been enrolling pregnant women and their babies since 2011 in the cohra2 study of genetic , microbial , and environmental factors involved in... |
further improvements in sequencing techniques have allowed sequences to be produced on a large scale and inserted into a computer .
appropriate programs , capable of processing data , have been developed to facilitate access and make all of the information available throughout the process ( morozova and marra , 2008 ... | improvements in genome sequencing techniques have resulted in generation of huge volumes of data . as a consequence of this progress , the genome assembly stage demands even more computational power , since the incoming sequence files contain large amounts of data . to speed up the process
, it is often necessary to ... |
the clinical implications of left axis deviation ( lad ) in patients with left bundle branch block ( lbbb ) have not been clearly elucidated .
some studies have reported that patients with lad do not have a significantly different prognosis compared with patients with a normal qrs axis,1)2)3 ) while others have shown... | background and objectivesleft bundle branch block ( lbbb ) with left axis deviation ( lad ) has a worse prognosis than lbbb with a normal axis , and myocardial dysfunction has been suggested as a cause of left axis deviation .
this study investigated the prognostic significance of the qrs axis in patients with lbbb a... |
rheumatoid arthritis ( ra ) and other connective tissue disorders are frequently associated with certain types of corneal or / and scleral pathology such as peripheral ulcerative keratitis , dry eye syndrome , and scleritis .
it is also known that these conditions may lead to perforation of the eye by compromising th... | purposethe purpose of this study is to report a case of corneal perforation in a patient with undiagnosed keratoconus and underlying rheumatoid arthritis.methodsthis is a retrospective case study based on the patient s medical records and followed by a brief review of the literature.resultsa 53-year - old patient was r... |
pushing the boundaries of surgical options in the curative treatment of hepatic malignancies has recently led to the development of a new surgical technique for patients in whom a conventional major liver resection ( 3 liver segments ) is not feasible .
the technique , known as alpps ( associating liver partition and... | alpps ( associating liver partition and portal vein ligation for staged hepatectomy ) is a new surgical technique for patients in whom conventional treatment is not feasible due to insufficient future remnant liver ( frl ) . during the first stage of alpps ,
accelerated hypertrophy of the frl is induced by ligation o... |
this is an interesting case of a child who , following a minor head injury a few weeks earlier , was initially found to have a thin chronic subdural haematoma on plain computed tomography ( ct ) imaging . following burr hole surgery for evacuation of the subdural haematoma his post - operative scan revealed an underlyi... | we present an unusual case of a 13-year - old child who following minor head injury presented with what appeared to be a thin chronic subdural hematoma on plain computed tomography imaging . the child was found to have an underlying arachnoid cyst .
intra- and extra - cystic bleeding had occurred simultaneously causi... |
like other mammals , cattle possess a large amount of single nucleotide polymorphisms ( snps ) in their genome .
the current ncbi dbsnp collection contains more than 2.2 million bovine snps ( http://www.ncbi.nlm.nih.gov/projects/genome/guide/cow/ ) . among them
, ~2.1 million snps were contributed by the baylor col... | the illumina bovinesnp50 beadchip features 54,001 informative single nucleotide polymorphisms ( snps ) that uniformly span the entire bovine genome . among them , 52,255 snps have locations assigned in the current genome assembly ( btau_4.0 ) , including 19,294 ( 37% ) intragenic snps ( i.e. , located within genes ) an... |
the purpose of this article is to report a case of central toxic keratopathy in a patient post transepithelial photorefractive keratectomy ( transprk ) , followed immediately by corneal collagen cross - linking .
this article describes the case of a 26-year - old male after bilateral aberration - free , transprk lase... | purposethe purpose of this article is to report a case of central toxic keratopathy in a patient post transepithelial photorefractive keratectomy ( transprk ) , followed immediately by corneal collagen cross-linking.methodsthis article describes the case of a 26-year - old male after bilateral aberration - free , trans... |
reactive oxygen ( ros ) and nitrogen ( nos ) species ( rons ) normally regulate many of the intracellular signaling cascades that govern multiple cellular activities .
however , when the amount of rons exceeds the cell s ability to metabolize / eliminate them , the cell becomes stressed and acquires genetic and epige... | there has been increasing interest lately in understanding how natural dietary antioxidants affect chemoprevention , and recently , there has been a merging of information about antioxidants , endogenous and exogenous reactive oxygen and nitrogen species ( rons ) , and inflammation .
rons normally serve the cells as ... |
pulmonary embolismis a major global public health concern , with an estimated 900,000 venous thromboembolic events occurring annually in the united states alone .
massive pulmonary embolism in non - surgical patients is relatively common and presents a high degree of mortality ( 25 - 65% ) . the incidence of massive ... | introductionthe management of massive intra - operative embolism remains controversial .
our hypothesis was that either surgical or medical thrombectomy offers survival benefit in these patients.methodspublished case reports were reviewed for intra - operative intra - cardiac or pulmonary embolism and outcomes for th... |
the capacity to produce antimicrobial peptides ( amps ) is widespread among gram - positive bacteria .
these amps are directed against competitive microorganisms in order to generate a selective advantage for the producer organism .
class i consists of the so - called lantibiotics , which are posttranslationally mo... | nisin is an antimicrobial peptide produced and secreted by several l. lactis strains and is specifically active against gram - positive bacteria . in previous studies ,
nisin was purified via cation exchange chromatography at low ph employing a single - step elution using 1 m nacl . here
, we describe an optimized... |
dental caries , periodontal disease , and opportunistic infections are among the common diseases of the oral cavity caused by the accumulation of pathogenic microorganisms , inappropriate nutritional habits , and improper oral hygiene [ 14 ] .
oral streptococci are the first isolated species to play a role in the for... | objectives . this study aimed to assess the effect of hydroalcoholic extract of punica granatum linn .
( p. granatum ) petal on streptococcus sanguinis , streptococcus mutans , streptococcus salivarius , streptococcus sobrinus , and enterococcus faecalis . materials and methods . in this in vitro study , p. granatum ... |
research from the last decades clearly shows that zinc has a vital role in neonatal development .
zinc is an essential trace element in humans and animals and is involved in countless metabolic and signaling pathways within the body .
however , a particular role of zinc in the immune system and brain has been repor... | a growing amount of research indicates that abnormalities in the gastrointestinal ( gi ) system during development might be a common factor in multiple neurological disorders and might be responsible for some of the shared comorbidities seen among these diseases .
for example , many patients with autism spectrum diso... |
the deficiency of vitamin d3 is commonly associated with chronic kidney disease ( ckd ) , and the prevalence of this hypovitaminosis increases as kidney function declines [ 1 , 2 ] .
several factors , such as aging , loss of appetite , and other factors affecting cutaneous synthesis , such as low sun exposure and ski... | although some studies revealed a positive relationship between vitamin d3 deficiency and inflammatory markers , there have been also many studies that failed to find this relationship .
the aim of this large scaled study is to determine the association between the level of plasma 25 hydroxy vitamin d3 [ 25-(oh ) d3 ]... |
the online version of this article ( doi:10.1007/s00415 - 012 - 6498 - 2 ) contains supplementary material , which is available to authorized users .
patients with an acute basilar artery occlusion ( bao ) have a high risk of long - lasting disability and death [ 1 , 2 ] .
although higher age , analyzed as a contin... | patients with an acute basilar artery occlusion ( bao ) have a high risk of long - lasting disability and death .
only limited data are available on functional outcome in elderly patients with bao . using data from the basilar artery international cooperation study
, we aimed to determine outcomes in patients 75 y... |
babesiosis is caused by a haemotropic protozoal parasite of the genus babesia , member of the phylum apicomplexa and transmitted by the bite of an infected tick ( 1 ) .
babesiosis can occur without producing symptoms , but also be severe and sometimes fatal due to the intraerythrocytic parasite development ( 1 ) .
... | backgrounda reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host - defense strategies of organisms to kill the parasite .
however , it is not well known whether these intermediates cause dna damage and oxidative stress in goats infected with babesia ovis .
... |
herpes simplex virus-1 ( hsv-1 ) and hsv-2 which are dna viruses of alphaherpesvirinae subfamily and herpesviridae family , are the aetiological agent of hsv infections .
these infections are among the infections most frequently encountered by humans , worldwide because humans are their only natural reservoirs , and ... | introduction : the epidemiology of herpes labialis has been relatively neglected .
the objective of this study was to determine the prevalence and risk factors of self - reported herpes labialis among nigerian dental health providers.materials and methods : this cross - sectional study of final year dental students a... |
bile leaks can result from penetrating injury , such as gunshot ( gsw ) or knife wounds , or from blunt trauma , such as motor vehicle ( mva ) or motorcycle accidents ( mca ) .
the incidence of bile leaks following hepatobiliary trauma ranges from 0.5 to 21% depending on the criteria and methods used to diagnose the ... | traumatic bile leaks often result in high morbidity and prolonged hospital stay that requires multimodality management .
data on endoscopic management of traumatic bile leaks are scarce .
our study objective was to evaluate the efficacy of the endoscopic management of a traumatic bile leak .
we performed a retros... |
giant intracranial aneurysms have a lower propensity to bleed than small and medium - sized lesions and they may present with symptoms secondary to mass effect . while the diagnosis of a giant aneurysm can be readily made on radiology
if there is any circulating component within the aneurysmal sac , establishing a pr... | giant anterior communicating artery aneurysms are rare .
apatient presented with visual dysfunction , gait ataxia and urinary incontinence .
mri showed a giant suprasellar mass . at surgery , the lesion was identified as being an aneurysm arising from the anterior communicating artery .
the difficulty in preopera... |
our ancestors knew that human beings , like plants , seeds , and other living things in the universe , were immersed in an evolutionary cycle .
thus , since the beginning of civilization , our ancestors have turned their gaze to the sky for answers and found that certain astronomical cycles overlap each other , just ... | the use of folk medicine has been widely embraced in many developed countries under the name of traditional , complementary and alternative medicine ( tcam ) and is now becoming the mainstream in the uk and the rest of europe , as well as in north america and australia .
diversity , easy accessibility , broad continu... |
in recent years , advances in neuroimaging and surgical interventions have significantly decreased neurosurgical mortality and morbidity .
however , postoperative central nervous system infection ( pcnsi ) remains one of the main reasons for poor prognosis in patients after neurosurgery .
interestingly , the americ... | aimour aim was to study the clinical features of postoperative meningitis after neurosurgery and identify the factors affecting the duration of treatment.methodsthis retrospective study assessed 283 patients with postoperative bacterial meningitis in the neurosurgery department of beijing tiantan hospital , beijing , p... |
larsenico ( as ) un metalloide associato a diverse rocce , specialmente a minerali contenenti solfuro , rivelandosi molto mobile nellambiente : lerosione delle rocce converte infatti i solfuri di as in ossido arsenioso che entra nel ciclo ambientale contaminando i corpi idrici e , attraverso la catena alimentare , dis... | the boi cerbus lagoon , facing a mining and industrial site in sardinia ( italy ) , is an important fishing area for the local population .
previous studies showed high concentrations of total arsenic ( astot ) in fish , molluscs and crustaceans sampled in the lagoon , and a possible exceeding of the provisional tole... |
exposure of the esophagus to caustic material can lead to necrosis , ulceration , fibrosis , and ultimately stricture .
balloon and bougie dilation have similar efficacies for treating these strictures , although stricture recurrence after balloon dilation can occur in up to 30% of these cases .
furthermore , a lon... | bougie or balloon dilation is a good short - term treatment for caustic esophageal strictures , although recurrence after dilation occurs in approximately 30% of these cases . therefore , long - term treatment options are required in some cases , and endoscopic incisional therapy has been used for patients with an anas... |
familial hypobetalipoproteinemia ( fhbl ) is a rare autosomal co - dominant genetic disorder of lipid metabolism .
it is characterized by serum low - density lipoprotein ( ldl ) cholesterol or apolipoprotein b ( apob ) levels 5th percentile .
apob is the largest of the apolipoproteins and is important in the format... | familial hypobetalipoproteinemia ( fhbl ) is a rare genetic disorder of lipid metabolism that is associated with abnormally low serum levels of low - density lipoprotein ( ldl ) cholesterol and apolipoprotein b. it is an autosomal co - dominant disorder , and depending on zygosity , the clinical manifestations may vary... |
airway inflammation and tissue remodeling that leads to peribronchial fibrosis are characteristic of copd , and contribute to the relentless progress of the disease.12 inhaled glucocorticoids are very effective anti - inflammatory agents in asthma , but have limited benefits in copd . reduced expression of histone deac... | objective and designreduced expression of histone deacetylase 2 ( hdac2 ) in alveolar macrophages and epithelial cells may account for reduced response of chronic obstructive pulmonary disease ( copd ) patients to glucocorticoids .
hdac2 expression and its role in mediating glucocorticoid effects on fibroblast functi... |
specificity is one of the foundational components of training success . in sport performance training ,
one of the initial steps in the design of an exercise regimen is the identification of movements specific to the needs of the individual , which may include joint angles , and muscle actions and recruitment ( 1 , 4... | the kettlebell swing ( kbs ) , emphasizing cyclical , explosive hip extension in the horizontal plane , aligns with movement- and velocity - specificity of sprinting .
the present study examined the effect of an eight - week kbs intervention on sprinting in recreationally - active females , in comparison to an eight ... |
in central and eastern european and central asian regions , countries report high rates of abortion , while at the same time displaying higher levels of secondary infertility ( females with previous life births ) .
additionally , the prevalence of primary infertility ( females with no previous life births ) is signif... | backgroundan economic value calculation was performed to estimate the lifetime net present value of in vitro fertilization ( ivf ) in ukraine , belarus , and kazakhstan.methodsnet lifetime tax revenues were used to represent governmental benefits accruing from a hypothetical cohort of an ivf population born in 2009 usi... |
every year , more than 1 billion people are infected and more than 1 million die from vector - borne diseases .
world health organization ( who ) has highlighted the serious and increasing threat of vector - borne diseases with the theme preventing vector - borne diseases and also with the slogan small bite , big ... | background . malaria still remains a public health problem in developing countries and changing environmental and climatic factors pose the biggest challenge in fighting against the scourge of malaria .
therefore , the study was designed to forecast malaria cases using climatic factors as predictors in delhi , india ... |
quality of services is one of the most important factors for growth , success , and the presences of organizations , and it was considered as an effective and comprehensive strategy in order to improve their performances throughout the world ( 1 , 2 ) . in the health sector compared with other sectors , the quality of ... | introductionthe main mission of hospitals in any health system is to deliver high quality healthcare for patients and meet their needs and expectations .
the aim of the current study was to assess the quality of the service of educational hospitals affiliated with kermanshah university of medical sciences in 2015 , f... |
anaplastic thyroid cancer ( atc ) is one of the most aggressive tumors in human medicine .
therefore , the prognosis of atc patients is one of the worst among the malignant tumors in general . despite multimodal treatment , which includes surgery ,
its annual incidence is about 2 per million residents and its share... | background . anaplastic thyroid cancer ( atc )
is one of the tumors with the shortest survival in human medicine . aim .
the aim was to determine the importance of age in survival of patients with atc .
material and methods .
we analyzed the data on 150 patients diagnosed with atc in the period from 1995 to 2... |
low back pain ( lbp ) is a representative musculoskeletal disease with a current prevalence
of 6090% ; more than 80% people will experience lbp at least once in their lifetime .
lbp occurs when a poor lifestyle weakens the muscular strength of the waist and excessive
loads on and tensions of the muscles create pa... | [ purpose ] this study investigated the effect of exhalation exercises on trunk muscle
activity and oswestry disability index by inducing trunk muscle activity through
increasing intra - abdominal pressure and activating muscles , contributing to spinal
stability . [ subjects and methods ] this intervention progr... |
low - grade fibromyxoid sarcoma ( lgfms ) is a distinctive variant of fibrosarcoma , which was first described as a pathologic entity by evans in 1987 .
lgfms presents as a rare soft tissue tumor with a high metastasizing potential , despite the benign histologic appearance
. these tumors usually occur in the lower... | low - grade fibromyxoid sarcoma ( lgfms ) is a distinctive variant of fibrosarcoma with a high metastasizing potential and is characterized by a long interval between tumor presentation and metastasis .
lgfms involving the maxillofacial region is a very rare entity with only six cases reported till date .
lgfms is ... |
monocortical miniscrew - type temporary anchorage devices have been widely used to move a single tooth or segments of teeth.1,2 in addition , some studies have proposed simultaneous distalization of the entire dentition by applying force vector(s ) from interradicular miniscrews to the main archwire.3 the underlying co... | objectivethe purpose of this study was to observe stress distribution and displacement patterns of the entire maxillary arch with regard to distalizing force vectors applied from interdental miniscrews.methodsa standard three - dimensional finite element model was constructed to simulate the maxillary teeth , periodont... |
gestational diabetes mellitus ( gdm ) is a common medical complication of pregnancy defined as any degree of glucose intolerance with onset or first recognition during pregnancy [ 1 , 2 ] .
the initial criteria for diagnosis were established more than 40 years ago ; however , these criteria did not necessarily iden... | background . controversy surrounds the decision to adopt the international association of diabetes and pregnancy study groups ( iadpsg ) criteria for the diagnosis of gestational diabetes mellitus ( gdm ) as fears that disease prevalence rates will soar have been raised . aims . to investigate the prevalence of pregnan... |
neuregulin 1 ( nrg1 ) is a ligand for the neu / erbb2 protooncogene and closely related to cell - cell signal interactions required for the growth and development of multiple organ systems .
nrg1 exerts its effect on the epithelium , cardiovascular system , and central nervous system ( cns ) . in early embryogenesis ... | neuregulin 1 ( nrg1 ) is associated with the pathogenesis of schizophrenia through controlling activation and signaling of neurotransmitter receptors .
influence to schizophrenia development by the nrg1 gene may differ in individuals , and genetic polymorphism is one of the factors affecting their differences .
ass... |
a total of 220 crc samples were obtained from patients who had undergone surgery between 2003 and 2004 at chonbuk national university hospital .
we obtained clinical data from the patients ' records , and survival data were collected in august 2011 .
this study received a local ethics committee approval from the in... | backgroundcortactin and focal adhesion kinase ( fak ) are two important components among actin cross - linking proteins that play a central role in cell migration.methodsthe aims of this study were to evaluate the expression of cortactin and fak in normal colorectal mucosa and colorectal adenocarcinoma ( crc ) using ti... |
the location and tissue characteristics on imaging studies are critical to narrow down the differential diagnosis of mediastinal masses .
the most frequent lesions encountered in the mediastinum are thymoma , neurogenic tumours and benign cysts , altogether representing 60% of patients with mediastinal masses .
neu... | backgroundmultiple different types of mediastinal masses may be encountered on imaging techniques in symptomatic or asymptomatic patients .
the location and composition of these lesions are critical to narrowing the differential diagnosis.methodsradiological compartmentalisation of the mediastinum helps in focusing t... |
a core principle of both financial investment and biology is that diversity leads to strength . in biology ,
hybrid vigor produces healthy organisms , because each parental genome contributes complementary strengths and balances the other 's weaknesses . in investing
, diversity spreads risk , maximizing the chance... | the national institute of general medical sciences ( nigms ) at the u.s . national institutes of health has an annual budget of more than $ 2.3 billion .
the institute uses these funds to support fundamental biomedical research and training at universities , medical schools , and other institutions across the country... |
the second generation polyamidoamine ( pamam ) dendrimer with amidoethanol surface groups and ethylenediamine core was purchased from sigma - aldrich ( poole , dorset , uk ) and used without further purification .
the metal salts : agno3 , cucl22h2o , zncl2 , feso4 , and fecl3 were purchased from fisher scientific ( ... | the electron capture dissociation ( ecd ) and collision - induced dissociation ( cid ) of complexes of polyamidoamine ( pamam ) dendrimers with metal ions ag+ , cu2 + , zn2 + , fe2 + , and fe3 + were determined by fourier transform ion cyclotron resonance mass spectrometry .
complexes were of the form [ pd + m + mh]5... |
the content of the paper is the responsibility of the authors alone . who may not necessarily agree .
the content of the paper is the responsibility of the authors alone . who may not necessarily agree . | abstractend - user involvement in hiv guidelines development is often little , late or absent .
other disciplines have long advocated handing over the stick ( i.e. power and control ) , as both ethical and strategic .
women hiv activists have called this respectful engagement with , and learning from , communities... |
hepatocellular carcinoma ( hcc ) is one of the most common malignancies and has a high mortality rate worldwide .
hcc usually develops in chronically damaged liver caused by an infection with the hepatitis b virus ( hbv ) or hepatitis c virus ( hcv ) , alcoholic abuse and nonalcoholic fatty liver disease .
recent p... | intracranial metastasis of hepatocellular carcinoma ( hcc ) is rare , but has an extremely poor prognosis .
we report a case with successful surgical removal of intracranial metastasis of hcc .
a 32-year - old man was admitted to our hospital with severe vomiting .
he had been followed for liver cirrhosis due to ... |
nurses routinely encounter by many stressful working conditions . a well - defined stress factor for nursing caregiver
this clinical condition ( agitation ) is also an early symptom of the acute withdrawal syndrome , especially following inappropriate use of naltrexone in addicted people , which may jeopardize health... | background : agitation is an early symptom of the acute opioid withdrawal syndrome in addicts that may start by inappropriate use of naltrexone
. the current drug interventions are not efficient or need critical care as well .
this study compares the clinical role of midazolam and diazepam for the management of agi... |
while the benefits of digital pathology in routine clinical use continue to inspire initiatives around the world , some european countries are arguably ahead of the curve .
there are now a number of sites using digital pathology for primary diagnostic review , for example , in sweden , the netherlands , finland , lit... | the nordic symposium on digital pathology ( ndp ) was created to promote knowledge exchange across stakeholders in health care , industry , and academia . in 2016 ,
the 4th ndp installment took place in linkping , sweden , promoting development and collaboration in digital pathology for the benefit of routine care ad... |
after ilizarov first reported successful distraction osteogenesis of the long bone , there was a report by mccarthy et al .
( 1 ) who were the first to perform a distraction osteogenesis of the human craniofacial mandible bone .
thereafter numerous studies reported on craniofacial bone expansion . in order to succe... | a 7-yr - old boy visited our surgical center with pfeiffer syndrome type 1 , presenting with macrocrania , broad big toe and thumb , exophthalmos , tongue protrusion , malocclusion with midfacial retrusion , mild respiratory difficulty due to minor upper airway obstruction , and developmental delay .
he also exhibite... |
aminoglycoside - induced proteinuria may result from general renal damage or may reflect alterations in specific steps in the renal handling of proteins . to differentiate between the two possibilities ,
experiments were designed to quantify the effects of nephrotoxic doses of gentamicin , tobramycin and netilmicin i... | |
myasthenia gravis ( mg ) is more commonly identified in younger individuals , especially women , and is usually associated with thymus disease . in these patients ,
however , elderly - onset mg has been also reported among patients 65 years of age.14 thymus abnormalities are usually rare among patients with late - on... | the number of patients with late - onset myasthenia gravis ( mg ) among patients 50 years has been increasing recently .
we encountered three patients who developed elderly - onset mg at a particularly advanced age ( 80 years ) .
all were female and positive for anti - acetylcholine receptor antibodies .
about 4 ... |
because this cancer is often asymptomatic , it is often diagnosed after a routine eye examination , unless the patient s central vision is affected . until about 1970 ,
enucleation was the standard treatment . in the early 1970s , radiotherapy and other treatment approaches , with the goal of preserving the eye , bec... | purposeto investigate tumor thickness and location , the interval of time between treatment for choroidal melanoma ( proton beam irradiation or enucleation ) and diagnosis of metastatic disease , and rates and sites of metastasis.designretrospective , interventional , noncomparative case series.methodsfollow-up of 152 ... |
a high demand for presbyopia correction at the time of cataract surgery has increased the implantation of multifocal intraocular lenses ( iols ) .
residual astigmatism is a concern with these lenses , because refractive astigmatism of 1.0 d or more can negatively impact visual outcomes with multifocal iols.1 this amo... | purposethe aim of this study was to compare a new diffractive trifocal toric lens with an apodized diffractive bifocal toric lens in terms of refractive and visual acuity ( va ) outcomes , including low - contrast va ( lcva ) , as well as the patient s visual function 3 months after implantation.patients and methodsthi... |
a common setup for image - guided neurosurgery uses a tracked pointer on a preoperative magnetic resonance imaging ( mri ) scan to visualize the tumor and its critical surroundings for guidance during the surgery .
this neuronavigation assists in tumor localization and resection and is a common practice in developed ... | the biggest challenge in neuro - oncology is the treatment of glioblastoma , which exhibits poor prognosis and is increasing in incidence in an increasing aging population .
diverse treatment strategies aim at maximum cytoreduction and ensuring good quality of life .
we discuss multimodal neuronavigation , supra - ... |
biologics , which represent new developments in genetic engineering and biotechnology , include t - cell modulators as well as tumor necrosis factor ( tnf)-alpha ( tnf- ) antagonists ( eg , etanercept , infliximab , and adalimumab [ humira ( d2e7 ) ; abbott laboratories , abbott park , il , usa ] ) .
these bioenginee... | it is recognized that immunosuppression may lead to reduced immune surveillance and tumor formation . because of the immunosuppressive properties of tumor necrosis factor ( tnf)-alpha ( tnf- ) antagonists , it is plausible that these biologics may increase the risk of the occurrence of malignancies or the reactivation ... |
in spite of improvements in surveillance and clinical treatment strategies , the overall survival ( os ) of hepatocellular carcinoma ( hcc ) patients is unsatisfactory due to the high incidence of tumor recurrence and metastasis even after hepatectomy and lack of effective adjuvant therapy .
identification of reliabl... | purposecell division cycle and apoptosis regulator 1 ( ccar1 ) plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid / thyroid nuclear receptors , -catenin , and p53 in a variety of cell types including different cancer cells . however , whether ccar1 protein is overexpress... |
an 82-year - old japanese man was referred for detailed examination of hyperkeratotic erythematous plaques on his palms and soles for 6 months .
two weeks before his first visit , he had undergone lung lobectomy for right lung squamous cell carcinoma ( scc ) .
laboratory findings showed elevations of eosinophil cou... | |
thus , these teeth often may require the use of an intracanal post for retention of the core 57,25,26 .
the post fits into a space created by the removal of a portion of filling material and this procedure may affect the quality of the apical seal6,7 . during mechanical preparation of the post space , the root canal ... | during mechanical preparation of the post space , the root canal filling may be twisted or vibrated , depending on several factors associated with the preparation technique and quality of filling.objective:the purpose of this study was to investigate the effect of immediate and delayed post space preparation on the int... |
annual influenza epidemics affect 1020% of the population resulting in substantial mortality and morbidity worldwide .
the incidence of influenza in temperate areas of the northern and southern hemispheres is characterized by seasonal cycles with marked peaks in winter ,
hence , suggesting a role for climate .
h... | background seasonality characterizing influenza epidemics suggests susceptibility to climate variation .
el nio southern oscillation ( enso ) , which involves two extreme events , el nio and la nia , is wellknown for its large effects on interannual climate variability . the influence of enso on several diseases ha... |
the children with idiopathic speech and language disorders are very heterogeneous by phenotype . the diagnosis of specific language impairment ( sli ) is generally made by applying exclusion and inclusion criteria according to icd 10 ( 1992 ) .
sli is diagnosed , if the speech language development is significantly de... | even though difficulties in motor development in children with speech and language disorders are widely known , hardly any attention is paid to the association between atypically rapidly occurring unassisted walking and delayed speech development .
the four children described here presented with a developmental behav... |
it is always difficult to write something new in a review , but is even more so when a topic has been as extensively covered over the last few years as the role of natriuretic peptides ( nps ) in the management of heart failure ( hf ) .
this review will present scientific evidence on nps , with a focus on n - termina... | n - terminal prohormone of brain natriuretic peptide ( nt - probnp ) is a versatile biomarker , that has been extensively studied in large cohorts of individuals in the general population , in subjects at risk for developing left ventricular dysfunction and cardiovascular events , and in patients with chronic or acutel... |
breast cancer is the most common cancer among us women and remains the number two cause of cancer death for us women .
the recent figures and facts published in 2008 by the american cancer association indicate that 1 in 8 us women are at risk of developing breast cancer in a life time and that 1 in 35 us women are ... | detection of clustered microcalcifications ( mcs ) in mammograms represents a significant step towards successful detection of breast cancer since their existence is one of the early signs of cancer . in this paper , a new framework that integrates bayesian classifier and a pattern synthesizing scheme for detecting mic... |
the belief that natural medicines are much safer than synthetic drugs has caused exceptional growth in human exposure to natural products , as plants , phytotherapeutic agents , and phytopharmaceutical products .
this fact has lead to a resurgence of scientific interest in their biological effects . in most countries... | papain , a phytotherapeutic agent , has been used in the treatment of eschars and as a debriding chemical agent to remove damaged or necrotic tissue of pressure ulcers and gangrene .
its benefits in these treatments are deemed effective , since more than 5000 patients , at the public university hospital at rio de jan... |
the beckwith wiedemann syndrome ( bws , omim 130650 ) is a congenital overgrowth disorder associated with dysregulation of imprinted genes located at chromosome 11p15.5 .
children affected by bws show with variable expressivity several characteristic features , including macroglossia , gigantism , abdominal wall def... | the overgrowth disorder beckwith wiedemann syndrome ( bws ) is associated with dysregulation of imprinted genes at chromosome 11p15.5 .
the molecular defects are heterogeneous but most of the cases are associated with defective dna methylation at either one of two imprinting control regions ( ic1 and ic2 ) or unipar... |
some heavy metals have been suspected of playing a role in the pathogenesis of nervous system diseases such as multiple sclerosis , amyotrophic lateral sclerosis , and alzheimer 's disease . in these disorders ,
autoantibodies against neural proteins are evident at some stage of the disease .
lead is known to affec... | |
anti - mullerian hormone ( amh ) , a polypeptide , secreted by the granulosa cells of the preantral and early developing antral follicles , has been shown to be a predictor of ovarian activity .
pcos patients show an increased number of antral follicles ; therefore they have higher circulating amh levels than the hea... | recently , myoinositol ( myo - ins ) and folic acid combination has gained an important role for treating polycystic ovary syndrome ( pcos ) , in addition to combined oral contraceptives ( coc ) .
we aimed to examine myo - ins effects on anti - mullerian hormone ( amh ) levels and compare them with those ones obtaine... |
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