harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
This is the first histologically confirmed case of NASH that was aggravated by raloxifene.	[ [ "raloxifene", "NASH" ] ]
Allergic and irritant contact dermatitis to calcipotriol.	[ [ "calcipotriol", "irritant contact dermatitis" ] ]
We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.	[ [ "diphenhydramine", "cardiac toxicity" ] ]
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.	[ [ "clozapine", "tremulous" ], [ "clozapine", "shivering" ], [ "clomipramine", "shivering" ], [ "clomipramine", "tremulous" ], [ "clozapine", "agitated" ], [ "clozapine", "behaving oddly" ], [ "clomipramine", "behaving oddly" ], [ "clomipramine", "confused" ], [ "clozapine", "sweating profusely" ], [ "clomipramine", "sweating profusely" ], [ "clomipramine", "agitated" ], [ "clozapine", "confused" ] ]
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).	[ [ "granulocyte colony-stimulating factor", "Systemic capillary leak syndrome" ], [ "G-CSF", "Systemic capillary leak syndrome" ] ]
We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).	[ [ "rituximab", "bronchiolitis obliterans with organizing pneumonia" ] ]
Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.	[ [ "Ibuprofen", "gastrointestinal adverse reactions" ] ]
CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.	[ [ "oxaliplatin", "DAT-positive hemolytic episode" ] ]
Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.	[ [ "tamoxifen", "carcinoma of the corpus uteri" ] ]
In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.	[ [ "ethambutol", "visual loss" ] ]
Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.	[ [ "magnesium sulfate", "hypermagnesemia" ] ]
Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.	[ [ "colchicine", "rhabdomylysis" ] ]
Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.	[ [ "trimethoprim", "pseudomembranous colitis" ], [ "trimethoprim", "colitis" ], [ "sulfamethoxazole", "colitis" ], [ "sulfamethoxazole", "pseudomembranous colitis" ] ]
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.	[ [ "Bisphosphonate", "osteonecrosis of the jaw" ] ]
We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.	[ [ "dapsone", "dapsone reaction" ], [ "dapsone", "fatal" ] ]
Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.	[ [ "olanzapine", "severe neutropenia" ] ]
A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.	[ [ "halcinonide", "glycosuria" ], [ "halcinonide", "postprandial hyperglycemia" ] ]
Didanosine also has a potential for inducing seizures.	[ [ "Didanosine", "seizures" ] ]
Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.	[ [ "cyclophosphamide", "Acute erythroid leukemia" ] ]
This was accepted as evidence for propranolol being the cause of this conduction disorder.	[ [ "propranolol", "conduction disorder" ] ]
Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.	[ [ "chlorambucil", "Fatal interstitial pneumonitis" ] ]
CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.	[ [ "venlafaxine", "serotonin syndrome" ], [ "sertraline", "extrapyramidal reactions" ], [ "venlafaxine", "extrapyramidal reactions" ], [ "metoclopramide", "extrapyramidal reactions" ], [ "metoclopramide", "serotonin syndrome" ], [ "sertraline", "serotonin syndrome" ] ]
A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.	[ [ "amiodarone", "symmetric sensorimotor polyneuropathy" ], [ "amiodarone", "cerebellar syndrome" ] ]
This report describes a case of bilateral ptosis induced by chloroquine.	[ [ "chloroquine", "bilateral ptosis" ] ]
We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.	[ [ "carboplatin", "hypersensitivity" ], [ "CBDCA", "hypersensitivity" ], [ "paclitaxel", "hypersensitivity" ] ]
Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.	[ [ "adrenaline", "dacryolith" ] ]
Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.	[ [ "penicillamine", "PV" ] ]
5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.	[ [ "5-fluorouracil", "peripheral neuropathy" ], [ "5-FU", "peripheral neuropathy" ] ]
The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.	[ [ "quinine", "reversible hearing loss" ] ]
It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.	[ [ "dexamethasone", "osteonecrosis" ] ]
Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.	[ [ "amiodarone", "Peripheral neuropathy" ], [ "amiodarone", "cerebellar syndrome" ] ]
Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.	[ [ "cisplatin", "progressive sensorineural hearing loss" ] ]
Reversible cholestasis with bile duct injury following azathioprine therapy.	[ [ "azathioprine", "cholestasis" ], [ "azathioprine", "bile duct injury" ] ]
Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.	[ [ "Captopril", "cutaneous side-effects" ] ]
Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.	[ [ "TCA", "Cushing's syndrome" ] ]
This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.	[ [ "Fosamax", "hypophosphatemia" ], [ "Fleet Phospho-Soda", "hypophosphatemia" ], [ "alendronate", "hypocalcemic tetany" ], [ "Fosamax", "hypocalcemic tetany" ], [ "alendronate", "hypophosphatemia" ], [ "Fleet Phospho-Soda", "hypocalcemic tetany" ] ]
BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.	[ [ "tamoxifen", "Ovarian cancer" ] ]
A case of fluoxetine induced seizures, in a person with Down syndrome, is described.	[ [ "fluoxetine", "seizures" ] ]
A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.	[ [ "trazodone", "movement disorder" ], [ "lithium", "movement disorder" ] ]
These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).	[ [ "IFN", "skin lesions" ], [ "interferon-alpha", "skin lesions" ] ]
A case of oculogyric crisis induced by metoclopramide is described in this paper.	[ [ "metoclopramide", "oculogyric crisis" ] ]
Serotonin syndrome caused by interaction between citalopram and fentanyl.	[ [ "citalopram", "Serotonin syndrome" ], [ "fentanyl", "Serotonin syndrome" ] ]
During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.	[ [ "cisplatin", "100 mg/m2" ], [ "cisplatin", "palmar pruritus" ], [ "cisplatin", "urticaria" ], [ "cisplatin", "edema" ] ]
Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.	[ [ "methotrexate", "granulomas" ], [ "methotrexate", "pneumonitis" ], [ "methotrexate", "Pulmonary eosinophilia" ] ]
Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.	[ [ "granulocyte macrophage-colony-stimulating factor", "Proliferation of abnormal bone marrow histiocytes" ] ]
A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.	[ [ "trimethoprim", "generalized erythema" ], [ "sulfamethoxazole", "generalized erythema" ] ]
Cimetidine is a rare cause of drug-induced fever.	[ [ "Cimetidine", "fever" ] ]
The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.	[ [ "phenytoin", "phenytoin toxicity" ] ]
Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.	[ [ "5-FU", "ectropion" ] ]
A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.	[ [ "alprazolam", "delirious" ] ]
High-dose methotrexate-associated acute renal failure may be an avoidable complication.	[ [ "methotrexate", "acute renal failure" ] ]
We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.	[ [ "ifosfamide", "lethal anuria" ] ]
Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.	[ [ "Ciprofloxacin", "hemorrhagic vasculitis" ] ]
A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.	[ [ "Etanercept", "tuberculosis" ], [ "Efalizumab", "tuberculosis" ] ]
Intrahepatic cholestasis and sicca complex after thiabendazole.	[ [ "thiabendazole", "Intrahepatic cholestasis" ], [ "thiabendazole", "sicca complex" ] ]
CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.	[ [ "ifosfamide", "NCSE" ] ]
Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.	[ [ "adenosine", "arrhythmia" ] ]
Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.	[ [ "lidocaine", "psychiatric symptoms" ] ]
Hepatoxicity is a rare complication of SRL therapy and may be connected with some diagnostic and/or therapeutic problems.	[ [ "SRL", "Hepatoxicity" ] ]
Neurotoxicity of intrathecal administration of amphotericin B.	[ [ "amphotericin B", "Neurotoxicity" ] ]
Restless legs syndrome due to interferon-alpha.	[ [ "interferon-alpha", "Restless legs syndrome" ] ]
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.	[ [ "cytosine arabinoside", "Toxic epidermal necrolysis" ] ]
Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.	[ [ "Minocycline", "autoimmune hepatitis" ] ]
Diagnosis of hypothyroidism during treatment can be difficult because of the common side effects of alpha interferon.	[ [ "alpha interferon", "hypothyroidism" ] ]
Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.	[ [ "gemcitabine", "symmetric, bullous, herpetiform eruption" ] ]
Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.	[ [ "clozapine", "Rhabdomyolysis" ] ]
Sexual dysfunction associated with intrathecal baclofen use: a report of two cases.	[ [ "baclofen", "Sexual dysfunction" ] ]
In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.	[ [ "gemcitabine", "pulmonary toxicity" ] ]
We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.	[ [ "TMP-SMX", "soft tissue infection" ] ]
We report a case of MMC-related hemolytic uremic syndrome, and discuss the etiologic parameters, clinical aspects, prognosis and treatment modalities of this severe syndrome.	[ [ "MMC", "hemolytic uremic syndrome" ] ]
Pilocarpine toxicity and the treatment of xerostomia.	[ [ "Pilocarpine", "Pilocarpine toxicity" ] ]
FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.	[ [ "fluticasone propionate", "growth retardation" ], [ "fluticasone propionate", "adrenal suppression" ] ]
The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.	[ [ "cyclophosphamide", "carcinoma" ] ]
We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.	[ [ "carbamazepine", "opisthotonus" ], [ "carbamazepine", "dystonia" ] ]
We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.	[ [ "didanosine", "fulminant hepatic failure" ] ]
The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.	[ [ "cimetidine", "hepatic dysfunction" ], [ "cimetidine", "impaired macrophage migration" ] ]
There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.	[ [ "lithium", "organic brain syndromes" ] ]
Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.	[ [ "Ambien", "death" ], [ "Zolpidem", "death" ] ]
We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.	[ [ "levofloxacin", "polymorphic ventricular tachycardia" ] ]
Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.	[ [ "IFN-alpha", "Minimal change disease" ] ]
Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.	[ [ "levofloxacin", "Acute delirium" ] ]
Interstitial pneumopathy and low-dosage amiodarone.	[ [ "amiodarone", "Interstitial pneumopathy" ] ]
Fluoxetine-induced akathisia: clinical and theoretical implications.	[ [ "Fluoxetine", "akathisia" ] ]
Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.	[ [ "propranolol", "Alternating sinus rhythm" ], [ "propranolol", "intermittent sinoatrial block" ] ]
Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.	[ [ "HU", "hepatic toxicity" ], [ "HU", "mild reversible hematologic" ] ]
A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.	[ [ "phenytoin", "unilateral gingival hyperplasia" ] ]
DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol.	[ [ "zuclopenthixol", "priapism" ] ]
The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.	[ [ "methimazole", "bile stasis" ], [ "methimazole", "cholestasis" ], [ "methimazole", "fatty liver parenchyma degeneration" ], [ "methimazole", "leucopenia" ], [ "methimazole", "granulocytic portal infiltration" ] ]
The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.	[ [ "risperidone", "RLS" ], [ "risperidone", "akathisia" ], [ "olanzapine", "akathisia" ], [ "olanzapine", "RLS" ] ]
Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.	[ [ "amiodarone", "torsades de pointe" ] ]
We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.	[ [ "granulocyte colony-stimulating factor", "CLS" ] ]
Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.	[ [ "5-FU", "dermatologic toxicities" ] ]
We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium (Depakote), resulting in serum concentrations 10 times greater than the therapeutic range.	[ [ "divalproex sodium", "symptomatic methemoglobinemia" ], [ "Depakote", "symptomatic methemoglobinemia" ] ]
We present a patient with human immunodeficiency virus infection under treatment with foscarnet for CMV retinitis who complained of thirst and polyuria.	[ [ "foscarnet", "thirst" ], [ "foscarnet", "polyuria" ] ]
Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.	[ [ "verapamil", "polymorphic ventricular tachycardia" ] ]
Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.	[ [ "Mesalamine", "hypersensitivity pneumonitis" ] ]
A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.	[ [ "tacrolimus", "sudden cutaneous reaction" ] ]
CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.	[ [ "Amphotericin B", "fatal" ] ]
Abnormal retinal function associated with isotretinoin therapy for acne.	[ [ "isotretinoin", "Abnormal retinal function" ] ]
We believe this is the first report of intrathecal diamorphine causing anaphylaxis.	[ [ "diamorphine", "anaphylaxis" ] ]

This is the first histologically confirmed case of NASH that was aggravated by raloxifene.

[ [ "raloxifene", "NASH" ] ]

Allergic and irritant contact dermatitis to calcipotriol.

[ [ "calcipotriol", "irritant contact dermatitis" ] ]

We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.

[ [ "diphenhydramine", "cardiac toxicity" ] ]

The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.

[ [ "clozapine", "tremulous" ], [ "clozapine", "shivering" ], [ "clomipramine", "shivering" ], [ "clomipramine", "tremulous" ], [ "clozapine", "agitated" ], [ "clozapine", "behaving oddly" ], [ "clomipramine", "behaving oddly" ], [ "clomipramine", "confused" ], [ "clozapine", "sweating profusely" ], [ "clomipramine", "sweating profusely" ], [ "clomipramine", "agitated" ], [ "clozapine", "confused" ] ]

Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).

[ [ "granulocyte colony-stimulating factor", "Systemic capillary leak syndrome" ], [ "G-CSF", "Systemic capillary leak syndrome" ] ]

We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).

[ [ "rituximab", "bronchiolitis obliterans with organizing pneumonia" ] ]

Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.

[ [ "Ibuprofen", "gastrointestinal adverse reactions" ] ]

CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.

[ [ "oxaliplatin", "DAT-positive hemolytic episode" ] ]

Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.

[ [ "tamoxifen", "carcinoma of the corpus uteri" ] ]

In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.

[ [ "ethambutol", "visual loss" ] ]

Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.

[ [ "magnesium sulfate", "hypermagnesemia" ] ]

Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.

[ [ "colchicine", "rhabdomylysis" ] ]

Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.

[ [ "trimethoprim", "pseudomembranous colitis" ], [ "trimethoprim", "colitis" ], [ "sulfamethoxazole", "colitis" ], [ "sulfamethoxazole", "pseudomembranous colitis" ] ]

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.

[ [ "Bisphosphonate", "osteonecrosis of the jaw" ] ]

We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.

[ [ "dapsone", "dapsone reaction" ], [ "dapsone", "fatal" ] ]

Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.

[ [ "olanzapine", "severe neutropenia" ] ]

A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.

[ [ "halcinonide", "glycosuria" ], [ "halcinonide", "postprandial hyperglycemia" ] ]

Didanosine also has a potential for inducing seizures.

[ [ "Didanosine", "seizures" ] ]

Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.

[ [ "cyclophosphamide", "Acute erythroid leukemia" ] ]

This was accepted as evidence for propranolol being the cause of this conduction disorder.

[ [ "propranolol", "conduction disorder" ] ]

Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.

[ [ "chlorambucil", "Fatal interstitial pneumonitis" ] ]

CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.

[ [ "venlafaxine", "serotonin syndrome" ], [ "sertraline", "extrapyramidal reactions" ], [ "venlafaxine", "extrapyramidal reactions" ], [ "metoclopramide", "extrapyramidal reactions" ], [ "metoclopramide", "serotonin syndrome" ], [ "sertraline", "serotonin syndrome" ] ]

A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.

[ [ "amiodarone", "symmetric sensorimotor polyneuropathy" ], [ "amiodarone", "cerebellar syndrome" ] ]

This report describes a case of bilateral ptosis induced by chloroquine.

[ [ "chloroquine", "bilateral ptosis" ] ]

We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.

[ [ "carboplatin", "hypersensitivity" ], [ "CBDCA", "hypersensitivity" ], [ "paclitaxel", "hypersensitivity" ] ]

Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.

[ [ "adrenaline", "dacryolith" ] ]

Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.

[ [ "penicillamine", "PV" ] ]

5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.

[ [ "5-fluorouracil", "peripheral neuropathy" ], [ "5-FU", "peripheral neuropathy" ] ]

The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.

[ [ "quinine", "reversible hearing loss" ] ]

It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.

[ [ "dexamethasone", "osteonecrosis" ] ]

Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.

[ [ "amiodarone", "Peripheral neuropathy" ], [ "amiodarone", "cerebellar syndrome" ] ]

Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.

[ [ "cisplatin", "progressive sensorineural hearing loss" ] ]

Reversible cholestasis with bile duct injury following azathioprine therapy.

[ [ "azathioprine", "cholestasis" ], [ "azathioprine", "bile duct injury" ] ]

Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.

[ [ "Captopril", "cutaneous side-effects" ] ]

Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.

[ [ "TCA", "Cushing's syndrome" ] ]

This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.

[ [ "Fosamax", "hypophosphatemia" ], [ "Fleet Phospho-Soda", "hypophosphatemia" ], [ "alendronate", "hypocalcemic tetany" ], [ "Fosamax", "hypocalcemic tetany" ], [ "alendronate", "hypophosphatemia" ], [ "Fleet Phospho-Soda", "hypocalcemic tetany" ] ]

BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.

[ [ "tamoxifen", "Ovarian cancer" ] ]

A case of fluoxetine induced seizures, in a person with Down syndrome, is described.

[ [ "fluoxetine", "seizures" ] ]

A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.

[ [ "trazodone", "movement disorder" ], [ "lithium", "movement disorder" ] ]

These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).

[ [ "IFN", "skin lesions" ], [ "interferon-alpha", "skin lesions" ] ]

A case of oculogyric crisis induced by metoclopramide is described in this paper.

[ [ "metoclopramide", "oculogyric crisis" ] ]

Serotonin syndrome caused by interaction between citalopram and fentanyl.

[ [ "citalopram", "Serotonin syndrome" ], [ "fentanyl", "Serotonin syndrome" ] ]

During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.

[ [ "cisplatin", "100 mg/m2" ], [ "cisplatin", "palmar pruritus" ], [ "cisplatin", "urticaria" ], [ "cisplatin", "edema" ] ]

Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.

[ [ "methotrexate", "granulomas" ], [ "methotrexate", "pneumonitis" ], [ "methotrexate", "Pulmonary eosinophilia" ] ]

Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.

[ [ "granulocyte macrophage-colony-stimulating factor", "Proliferation of abnormal bone marrow histiocytes" ] ]

A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.

[ [ "trimethoprim", "generalized erythema" ], [ "sulfamethoxazole", "generalized erythema" ] ]

Cimetidine is a rare cause of drug-induced fever.

[ [ "Cimetidine", "fever" ] ]

The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.

[ [ "phenytoin", "phenytoin toxicity" ] ]

Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.

[ [ "5-FU", "ectropion" ] ]

A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.

[ [ "alprazolam", "delirious" ] ]

High-dose methotrexate-associated acute renal failure may be an avoidable complication.

[ [ "methotrexate", "acute renal failure" ] ]

We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.

[ [ "ifosfamide", "lethal anuria" ] ]

Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.

[ [ "Ciprofloxacin", "hemorrhagic vasculitis" ] ]

A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.

[ [ "Etanercept", "tuberculosis" ], [ "Efalizumab", "tuberculosis" ] ]

Intrahepatic cholestasis and sicca complex after thiabendazole.

[ [ "thiabendazole", "Intrahepatic cholestasis" ], [ "thiabendazole", "sicca complex" ] ]

CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.

[ [ "ifosfamide", "NCSE" ] ]

Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.

[ [ "adenosine", "arrhythmia" ] ]

Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.

[ [ "lidocaine", "psychiatric symptoms" ] ]

Hepatoxicity is a rare complication of SRL therapy and may be connected with some diagnostic and/or therapeutic problems.

[ [ "SRL", "Hepatoxicity" ] ]

Neurotoxicity of intrathecal administration of amphotericin B.

[ [ "amphotericin B", "Neurotoxicity" ] ]

Restless legs syndrome due to interferon-alpha.

[ [ "interferon-alpha", "Restless legs syndrome" ] ]

Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.

[ [ "cytosine arabinoside", "Toxic epidermal necrolysis" ] ]

Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.

[ [ "Minocycline", "autoimmune hepatitis" ] ]

Diagnosis of hypothyroidism during treatment can be difficult because of the common side effects of alpha interferon.

[ [ "alpha interferon", "hypothyroidism" ] ]

Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.

[ [ "gemcitabine", "symmetric, bullous, herpetiform eruption" ] ]

Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.

[ [ "clozapine", "Rhabdomyolysis" ] ]

Sexual dysfunction associated with intrathecal baclofen use: a report of two cases.

[ [ "baclofen", "Sexual dysfunction" ] ]

In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.

[ [ "gemcitabine", "pulmonary toxicity" ] ]

We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.

[ [ "TMP-SMX", "soft tissue infection" ] ]

We report a case of MMC-related hemolytic uremic syndrome, and discuss the etiologic parameters, clinical aspects, prognosis and treatment modalities of this severe syndrome.

[ [ "MMC", "hemolytic uremic syndrome" ] ]

Pilocarpine toxicity and the treatment of xerostomia.

[ [ "Pilocarpine", "Pilocarpine toxicity" ] ]

FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.

[ [ "fluticasone propionate", "growth retardation" ], [ "fluticasone propionate", "adrenal suppression" ] ]

The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.

[ [ "cyclophosphamide", "carcinoma" ] ]

We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.

[ [ "carbamazepine", "opisthotonus" ], [ "carbamazepine", "dystonia" ] ]

We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.

[ [ "didanosine", "fulminant hepatic failure" ] ]

The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.

[ [ "cimetidine", "hepatic dysfunction" ], [ "cimetidine", "impaired macrophage migration" ] ]

There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.

[ [ "lithium", "organic brain syndromes" ] ]

Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.

[ [ "Ambien", "death" ], [ "Zolpidem", "death" ] ]

We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.

[ [ "levofloxacin", "polymorphic ventricular tachycardia" ] ]

Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.

[ [ "IFN-alpha", "Minimal change disease" ] ]

Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.

[ [ "levofloxacin", "Acute delirium" ] ]

Interstitial pneumopathy and low-dosage amiodarone.

[ [ "amiodarone", "Interstitial pneumopathy" ] ]

Fluoxetine-induced akathisia: clinical and theoretical implications.

[ [ "Fluoxetine", "akathisia" ] ]

Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.

[ [ "propranolol", "Alternating sinus rhythm" ], [ "propranolol", "intermittent sinoatrial block" ] ]

Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.

[ [ "HU", "hepatic toxicity" ], [ "HU", "mild reversible hematologic" ] ]

A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.

[ [ "phenytoin", "unilateral gingival hyperplasia" ] ]

DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol.

[ [ "zuclopenthixol", "priapism" ] ]

The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.

[ [ "methimazole", "bile stasis" ], [ "methimazole", "cholestasis" ], [ "methimazole", "fatty liver parenchyma degeneration" ], [ "methimazole", "leucopenia" ], [ "methimazole", "granulocytic portal infiltration" ] ]

The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.

[ [ "risperidone", "RLS" ], [ "risperidone", "akathisia" ], [ "olanzapine", "akathisia" ], [ "olanzapine", "RLS" ] ]

Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.

[ [ "amiodarone", "torsades de pointe" ] ]

We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.

[ [ "granulocyte colony-stimulating factor", "CLS" ] ]

Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.

[ [ "5-FU", "dermatologic toxicities" ] ]

We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium (Depakote), resulting in serum concentrations 10 times greater than the therapeutic range.

[ [ "divalproex sodium", "symptomatic methemoglobinemia" ], [ "Depakote", "symptomatic methemoglobinemia" ] ]

We present a patient with human immunodeficiency virus infection under treatment with foscarnet for CMV retinitis who complained of thirst and polyuria.

[ [ "foscarnet", "thirst" ], [ "foscarnet", "polyuria" ] ]

Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.

[ [ "verapamil", "polymorphic ventricular tachycardia" ] ]

Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.

[ [ "Mesalamine", "hypersensitivity pneumonitis" ] ]

A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.

[ [ "tacrolimus", "sudden cutaneous reaction" ] ]

CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.

[ [ "Amphotericin B", "fatal" ] ]

Abnormal retinal function associated with isotretinoin therapy for acne.

[ [ "isotretinoin", "Abnormal retinal function" ] ]

We believe this is the first report of intrathecal diamorphine causing anaphylaxis.

[ [ "diamorphine", "anaphylaxis" ] ]