harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.	[ [ "phenytoin", "focal neurological deficit" ] ]
We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.	[ [ "mebendazole", "alopecia" ], [ "mebendazole", "granulocytopenia" ] ]
A diagnosis of trastuzumab-induced pneumonitis was made.	[ [ "trastuzumab", "pneumonitis" ] ]
Seizures and transient blindness following intravenous pulse methylprednisolone in children with primary glomerulonephritis.	[ [ "methylprednisolone", "Seizures" ], [ "methylprednisolone", "transient blindness" ] ]
Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.	[ [ "ranibizumab", "Ocular hypertension" ] ]
We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.	[ [ "phenol-glycerine", "anterior spinal artery syndrome" ] ]
High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.	[ [ "methylprednisolone", "adrenal suppression" ] ]
A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.	[ [ "sulfasalazine", "skin pigmentation" ], [ "sulfasalazine", "diffuse pulmonary shadowing" ] ]
Duodenal ulceration: a complication of tolazoline therapy.	[ [ "tolazoline", "Duodenal ulceration" ] ]
Thalidomide neuropathy is often associated with proximal weakness and may progress even after discontinuation of treatment, in the phenomenon of 'coasting'.	[ [ "Thalidomide", "proximal weakness" ], [ "Thalidomide", "neuropathy" ] ]
CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.	[ [ "Gemcitabine", "recall pneumonitis" ] ]
Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.	[ [ "octreotide", "prolonged hypoglycemia" ] ]
A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.	[ [ "levetiracetam", "acute psychosis" ] ]
Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.	[ [ "Norethisterone", "clitoral hypertrophy" ] ]
Enalapril-induced anemia in two kidney transplant recipients.	[ [ "Enalapril", "anemia" ] ]
It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.	[ [ "oxaliplatinum", "pulmonary adverse reaction" ], [ "5-fluorouracil", "pulmonary adverse reaction" ] ]
Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.	[ [ "haloperidol", "multiform ventricular tachycardia" ] ]
Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.	[ [ "mitomycin C", "Comeoscleral perforation" ] ]
We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.	[ [ "gold", "severe neutropenia" ] ]
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.	[ [ "imiquimod", "Psoriasis" ] ]
5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.	[ [ "5-Fluorouracil", "cardiotoxicity" ] ]
Isoniazid-induced anaphylaxis.	[ [ "Isoniazid", "anaphylaxis" ] ]
Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.	[ [ "CBDCA", "hypersensitivity" ] ]
Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.	[ [ "Rifampin", "hypothyroidism" ], [ "Rifampin", "Hashimoto's thyroiditis" ], [ "RFP", "hypothyroidism" ], [ "RFP", "Hashimoto's thyroiditis" ] ]
Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.	[ [ "acenocoumarol", "Laryngeal dyspnea" ], [ "econazole", "Laryngeal dyspnea" ] ]
We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.	[ [ "rofecoxib", "decline in glomerular filtration rate" ] ]
Acute renal failure is a rare complication following the administration of intravenous immunoglobulin (IVIG).	[ [ "immunoglobulin", "Acute renal failure" ] ]
Lethargy in a newborn: lithium toxicity or lab error?	[ [ "lithium", "lithium toxicity" ], [ "lithium", "Lethargy" ] ]
A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).	[ [ "propylthiouracil", "raised creatine phosphokinase" ], [ "propylthiouracil", "severe proximal muscle weakness" ], [ "propylthiouracil", "hyperthyroidism" ] ]
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.	[ [ "5-ASA", "fever" ], [ "prednisone", "worsening respiratory distress" ], [ "5-ASA", "worsening respiratory distress" ], [ "prednisone", "fever" ], [ "mesalamine", "fever" ], [ "mesalamine", "worsening respiratory distress" ] ]
Possible mechanisms for damage to the urothelium by ketamine are suggested.	[ [ "ketamine", "damage to the urothelium" ] ]
Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.	[ [ "penicillamine", "brain lesions" ] ]
As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.	[ [ "AZ", "acute hemorrhagic gastritis" ], [ "AZ", "AZ intoxication" ] ]
A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.	[ [ "clozapine", "tonic-clonic seizures" ] ]
Bisphosphonate induced osteochemonecrosis of the jaw mimicking a tumour.	[ [ "Bisphosphonate", "osteochemonecrosis of the jaw" ] ]
We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.	[ [ "L-asparaginase", "seizures" ], [ "L-asparaginase", "altered sensorium" ] ]
Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made.	[ [ "insulin", "lipohypertrophy" ] ]
Pemphigus foliaceus induced by rifampicin.	[ [ "rifampicin", "Pemphigus foliaceus" ] ]
These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.	[ [ "quetiapine", "deaths" ] ]
Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.	[ [ "imatinib", "hepatotoxicity" ] ]
We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.	[ [ "doxycycline", "fever" ], [ "doxycycline", "AILD" ], [ "doxycycline", "generalized pruritic maculopapular eruption" ] ]
Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.	[ [ "CBZ", "seizures" ] ]
Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.	[ [ "valacyclovir", "Neurotoxicity" ] ]
Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.	[ [ "allopurinol", "Telescoped digits of the hands and feet" ] ]
Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.	[ [ "ibopamine", "Reversible leukopenia" ] ]
After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.	[ [ "captopril", "radiographic abnormalities" ], [ "captopril", "eosinophilia" ] ]
Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.	[ [ "ferrous sulfate", "reduce the gastrointestinal absorption of orally administered levothyroxine sodium" ] ]
After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).	[ [ "infliximab", "severe transient neutropenia" ] ]
We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.	[ [ "ampicillin", "TEN" ] ]
CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.	[ [ "insulin", "protamine allergy" ] ]
A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam-induced eating disorder.	[ [ "triazolam", "eating disorder" ] ]
A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.	[ [ "amphotericin B", "nephrotoxicity" ] ]
Salicylate intoxication was excluded, and theophylline was finally incriminated.	[ [ "theophylline", "intoxication" ] ]
Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.	[ [ "griseofulvin", "systemic lupus erythematosus" ], [ "griseofulvin", "Nephrotic syndrome" ] ]
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.	[ [ "TMP-Sx", "SJS" ], [ "trimethoprim-sulfamethoxazole", "Stevens-Johnson syndrome" ], [ "trimethoprim-sulfamethoxazole", "TEN" ], [ "trimethoprim-sulfamethoxazole", "toxic epidermal necrolysis" ], [ "trimethoprim-sulfamethoxazole", "SJS" ], [ "TMP-Sx", "TEN" ], [ "TMP-Sx", "Stevens-Johnson syndrome" ], [ "TMP-Sx", "toxic epidermal necrolysis" ] ]
Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.	[ [ "clindamycin", "pseudomembranous colitis" ] ]
The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.	[ [ "bleomycin", "skin toxicity" ] ]
Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures.	[ [ "clozapine", "seizures" ] ]
Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.	[ [ "sulfasalazine", "skin pigmentation" ], [ "sulfasalazine", "Pulmonary infiltrates" ] ]
He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.	[ [ "MTX", "hypersensitivity reaction" ], [ "MTX", "chest tightness" ], [ "MTX", "diffuse urticaria" ], [ "MTX", "facial swelling" ], [ "MTX", "cough" ] ]
The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.	[ [ "zolmitriptan", "spinal cord infarction" ] ]
METHODS: Three patients with apparent itraconazole-induced liver injury were studied.	[ [ "itraconazole", "liver injury" ] ]
OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.	[ [ "olanzapine", "elevation of serum creatine kinase" ] ]
The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.	[ [ "IFN-beta", "monoarthritis" ] ]
Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.	[ [ "all-trans retinoic acid", "Pulmonary leukostasis" ] ]
Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.	[ [ "clozapine", "agranulocytosis" ], [ "phenothiazines", "Neutropenia" ], [ "phenothiazines", "agranulocytosis" ], [ "clozapine", "Neutropenia" ] ]
This paper reports a case of fatal perhexiline maleate liver injury.	[ [ "perhexiline maleate", "fatal perhexiline maleate liver injury" ] ]
We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.	[ [ "interferon alpha 2a", "vitiligo" ] ]
The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.	[ [ "rituximab", "delayed pulmonary toxicity" ] ]
Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.	[ [ "etanercept", "Thymic enlargement" ] ]
CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.	[ [ "quinapril", "irritating cough" ] ]
Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.	[ [ "TCA", "Cushing's syndrome" ] ]
Angioedema and dysphagia caused by contact allergy to inhaled budesonide.	[ [ "budesonide", "Angioedema" ], [ "budesonide", "dysphagia" ] ]
Oesophageal ulceration due to emepronium bromide.	[ [ "emepronium bromide", "Oesophageal ulceration" ] ]
Ciprofloxacin-induced hemorrhagic vasculitis.	[ [ "Ciprofloxacin", "hemorrhagic vasculitis" ] ]
Three cases of gold-related neuropathy are reported.	[ [ "gold", "neuropathy" ] ]
Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.	[ [ "itraconazole", "mild left ptosis" ], [ "itraconazole", "absence of deep reflexes" ], [ "itraconazole", "severe paralysis of the lower extremities" ], [ "itraconazole", "paralytic ileus" ], [ "itraconazole", "neurogenic bladder" ], [ "itraconazole", "mild weakness of the upper extremities" ] ]
The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.	[ [ "statin", "muscle weakness" ], [ "colchicine", "muscle weakness" ] ]
k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.	[ [ "lithium", "bucco-linguo-masticatory dyskinesia" ], [ "lithium", "akathisia" ] ]
The exophthalmos improved dramatically within 72 hours of the withdrawal of lithium.	[ [ "lithium", "exophthalmos" ] ]
OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.	[ [ "progestin", "squamous metaplasia within endometrial glands" ] ]
Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.	[ [ "metronidazole", "lactate elevation" ] ]
The gynecomastia regressed when the theophylline was discontinued.	[ [ "theophylline", "gynecomastia" ] ]
Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.	[ [ "L-tryptophan", "eosinophilia-myalgia syndrome" ] ]
Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.	[ [ "interferon-alpha", "Hashimoto's disease" ] ]
Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.	[ [ "phenytoin", "maculopapular rashes" ], [ "phenytoin", "Fever" ] ]
A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.	[ [ "quinine", "thrombotic microangiopathy" ], [ "quinine", "TMA" ] ]
MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.	[ [ "epirubicin", "primary and secondary perforation of the bladder" ] ]
A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.	[ [ "phenytoin", "basilar invagination" ] ]
The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.	[ [ "clioquinol", "transient global amnesia" ], [ "clioquinol", "retrograde amnesia" ] ]
Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.	[ [ "sorafenib", "Interstitial pneumonia" ] ]
Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.	[ [ "sulfamethoxazole-trimethoprim", "renal tubular dysfunction" ], [ "sulfamethoxazole-trimethoprim", "Hyperkalaemia" ] ]
Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command.	[ [ "morphine", "hypotensive" ], [ "morphine", "bradypneic" ] ]
Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.	[ [ "asparaginase", "hyperglycemia" ] ]
We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.	[ [ "CHOP", "supravenous hyperpigmentation" ] ]
Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.	[ [ "Fenclofenac", "IgA deficiency" ] ]
Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.	[ [ "4-chloro-7-nitrobenzofurazan", "Allergic contact dermatitis" ] ]
Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.	[ [ "Warfarin", "bleeding" ] ]
One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.	[ [ "epinephrine", "coronary artery vasospasm" ] ]
Ampicillin-associated seizures.	[ [ "Ampicillin", "seizures" ] ]

A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.

[ [ "phenytoin", "focal neurological deficit" ] ]

We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.

[ [ "mebendazole", "alopecia" ], [ "mebendazole", "granulocytopenia" ] ]

A diagnosis of trastuzumab-induced pneumonitis was made.

[ [ "trastuzumab", "pneumonitis" ] ]

Seizures and transient blindness following intravenous pulse methylprednisolone in children with primary glomerulonephritis.

[ [ "methylprednisolone", "Seizures" ], [ "methylprednisolone", "transient blindness" ] ]

Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.

[ [ "ranibizumab", "Ocular hypertension" ] ]

We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.

[ [ "phenol-glycerine", "anterior spinal artery syndrome" ] ]

High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.

[ [ "methylprednisolone", "adrenal suppression" ] ]

A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.

[ [ "sulfasalazine", "skin pigmentation" ], [ "sulfasalazine", "diffuse pulmonary shadowing" ] ]

Duodenal ulceration: a complication of tolazoline therapy.

[ [ "tolazoline", "Duodenal ulceration" ] ]

Thalidomide neuropathy is often associated with proximal weakness and may progress even after discontinuation of treatment, in the phenomenon of 'coasting'.

[ [ "Thalidomide", "proximal weakness" ], [ "Thalidomide", "neuropathy" ] ]

CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.

[ [ "Gemcitabine", "recall pneumonitis" ] ]

Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.

[ [ "octreotide", "prolonged hypoglycemia" ] ]

A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.

[ [ "levetiracetam", "acute psychosis" ] ]

Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.

[ [ "Norethisterone", "clitoral hypertrophy" ] ]

Enalapril-induced anemia in two kidney transplant recipients.

[ [ "Enalapril", "anemia" ] ]

It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.

[ [ "oxaliplatinum", "pulmonary adverse reaction" ], [ "5-fluorouracil", "pulmonary adverse reaction" ] ]

Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.

[ [ "haloperidol", "multiform ventricular tachycardia" ] ]

Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.

[ [ "mitomycin C", "Comeoscleral perforation" ] ]

We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.

[ [ "gold", "severe neutropenia" ] ]

Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.

[ [ "imiquimod", "Psoriasis" ] ]

5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.

[ [ "5-Fluorouracil", "cardiotoxicity" ] ]

Isoniazid-induced anaphylaxis.

[ [ "Isoniazid", "anaphylaxis" ] ]

Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.

[ [ "CBDCA", "hypersensitivity" ] ]

Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.

[ [ "Rifampin", "hypothyroidism" ], [ "Rifampin", "Hashimoto's thyroiditis" ], [ "RFP", "hypothyroidism" ], [ "RFP", "Hashimoto's thyroiditis" ] ]

Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.

[ [ "acenocoumarol", "Laryngeal dyspnea" ], [ "econazole", "Laryngeal dyspnea" ] ]

We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.

[ [ "rofecoxib", "decline in glomerular filtration rate" ] ]

Acute renal failure is a rare complication following the administration of intravenous immunoglobulin (IVIG).

[ [ "immunoglobulin", "Acute renal failure" ] ]

Lethargy in a newborn: lithium toxicity or lab error?

[ [ "lithium", "lithium toxicity" ], [ "lithium", "Lethargy" ] ]

A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).

[ [ "propylthiouracil", "raised creatine phosphokinase" ], [ "propylthiouracil", "severe proximal muscle weakness" ], [ "propylthiouracil", "hyperthyroidism" ] ]

A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.

[ [ "5-ASA", "fever" ], [ "prednisone", "worsening respiratory distress" ], [ "5-ASA", "worsening respiratory distress" ], [ "prednisone", "fever" ], [ "mesalamine", "fever" ], [ "mesalamine", "worsening respiratory distress" ] ]

Possible mechanisms for damage to the urothelium by ketamine are suggested.

[ [ "ketamine", "damage to the urothelium" ] ]

Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.

[ [ "penicillamine", "brain lesions" ] ]

As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.

[ [ "AZ", "acute hemorrhagic gastritis" ], [ "AZ", "AZ intoxication" ] ]

A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.

[ [ "clozapine", "tonic-clonic seizures" ] ]

Bisphosphonate induced osteochemonecrosis of the jaw mimicking a tumour.

[ [ "Bisphosphonate", "osteochemonecrosis of the jaw" ] ]

We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.

[ [ "L-asparaginase", "seizures" ], [ "L-asparaginase", "altered sensorium" ] ]

Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made.

[ [ "insulin", "lipohypertrophy" ] ]

Pemphigus foliaceus induced by rifampicin.

[ [ "rifampicin", "Pemphigus foliaceus" ] ]

These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.

[ [ "quetiapine", "deaths" ] ]

Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.

[ [ "imatinib", "hepatotoxicity" ] ]

We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.

[ [ "doxycycline", "fever" ], [ "doxycycline", "AILD" ], [ "doxycycline", "generalized pruritic maculopapular eruption" ] ]

Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.

[ [ "CBZ", "seizures" ] ]

Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.

[ [ "valacyclovir", "Neurotoxicity" ] ]

Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.

[ [ "allopurinol", "Telescoped digits of the hands and feet" ] ]

Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.

[ [ "ibopamine", "Reversible leukopenia" ] ]

After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.

[ [ "captopril", "radiographic abnormalities" ], [ "captopril", "eosinophilia" ] ]

Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.

[ [ "ferrous sulfate", "reduce the gastrointestinal absorption of orally administered levothyroxine sodium" ] ]

After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).

[ [ "infliximab", "severe transient neutropenia" ] ]

We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.

[ [ "ampicillin", "TEN" ] ]

CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.

[ [ "insulin", "protamine allergy" ] ]

A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam-induced eating disorder.

[ [ "triazolam", "eating disorder" ] ]

A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.

[ [ "amphotericin B", "nephrotoxicity" ] ]

Salicylate intoxication was excluded, and theophylline was finally incriminated.

[ [ "theophylline", "intoxication" ] ]

Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.

[ [ "griseofulvin", "systemic lupus erythematosus" ], [ "griseofulvin", "Nephrotic syndrome" ] ]

We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.

[ [ "TMP-Sx", "SJS" ], [ "trimethoprim-sulfamethoxazole", "Stevens-Johnson syndrome" ], [ "trimethoprim-sulfamethoxazole", "TEN" ], [ "trimethoprim-sulfamethoxazole", "toxic epidermal necrolysis" ], [ "trimethoprim-sulfamethoxazole", "SJS" ], [ "TMP-Sx", "TEN" ], [ "TMP-Sx", "Stevens-Johnson syndrome" ], [ "TMP-Sx", "toxic epidermal necrolysis" ] ]

Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.

[ [ "clindamycin", "pseudomembranous colitis" ] ]

The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.

[ [ "bleomycin", "skin toxicity" ] ]

Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures.

[ [ "clozapine", "seizures" ] ]

Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.

[ [ "sulfasalazine", "skin pigmentation" ], [ "sulfasalazine", "Pulmonary infiltrates" ] ]

He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.

[ [ "MTX", "hypersensitivity reaction" ], [ "MTX", "chest tightness" ], [ "MTX", "diffuse urticaria" ], [ "MTX", "facial swelling" ], [ "MTX", "cough" ] ]

The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.

[ [ "zolmitriptan", "spinal cord infarction" ] ]

METHODS: Three patients with apparent itraconazole-induced liver injury were studied.

[ [ "itraconazole", "liver injury" ] ]

OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.

[ [ "olanzapine", "elevation of serum creatine kinase" ] ]

The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.

[ [ "IFN-beta", "monoarthritis" ] ]

Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.

[ [ "all-trans retinoic acid", "Pulmonary leukostasis" ] ]

Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.

[ [ "clozapine", "agranulocytosis" ], [ "phenothiazines", "Neutropenia" ], [ "phenothiazines", "agranulocytosis" ], [ "clozapine", "Neutropenia" ] ]

This paper reports a case of fatal perhexiline maleate liver injury.

[ [ "perhexiline maleate", "fatal perhexiline maleate liver injury" ] ]

We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.

[ [ "interferon alpha 2a", "vitiligo" ] ]

The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.

[ [ "rituximab", "delayed pulmonary toxicity" ] ]

Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.

[ [ "etanercept", "Thymic enlargement" ] ]

CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.

[ [ "quinapril", "irritating cough" ] ]

Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.

[ [ "TCA", "Cushing's syndrome" ] ]

Angioedema and dysphagia caused by contact allergy to inhaled budesonide.

[ [ "budesonide", "Angioedema" ], [ "budesonide", "dysphagia" ] ]

Oesophageal ulceration due to emepronium bromide.

[ [ "emepronium bromide", "Oesophageal ulceration" ] ]

Ciprofloxacin-induced hemorrhagic vasculitis.

[ [ "Ciprofloxacin", "hemorrhagic vasculitis" ] ]

Three cases of gold-related neuropathy are reported.

[ [ "gold", "neuropathy" ] ]

Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.

[ [ "itraconazole", "mild left ptosis" ], [ "itraconazole", "absence of deep reflexes" ], [ "itraconazole", "severe paralysis of the lower extremities" ], [ "itraconazole", "paralytic ileus" ], [ "itraconazole", "neurogenic bladder" ], [ "itraconazole", "mild weakness of the upper extremities" ] ]

The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.

[ [ "statin", "muscle weakness" ], [ "colchicine", "muscle weakness" ] ]

k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.

[ [ "lithium", "bucco-linguo-masticatory dyskinesia" ], [ "lithium", "akathisia" ] ]

The exophthalmos improved dramatically within 72 hours of the withdrawal of lithium.

[ [ "lithium", "exophthalmos" ] ]

OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.

[ [ "progestin", "squamous metaplasia within endometrial glands" ] ]

Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.

[ [ "metronidazole", "lactate elevation" ] ]

The gynecomastia regressed when the theophylline was discontinued.

[ [ "theophylline", "gynecomastia" ] ]

Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.

[ [ "L-tryptophan", "eosinophilia-myalgia syndrome" ] ]

Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.

[ [ "interferon-alpha", "Hashimoto's disease" ] ]

Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.

[ [ "phenytoin", "maculopapular rashes" ], [ "phenytoin", "Fever" ] ]

A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.

[ [ "quinine", "thrombotic microangiopathy" ], [ "quinine", "TMA" ] ]

MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.

[ [ "epirubicin", "primary and secondary perforation of the bladder" ] ]

A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.

[ [ "phenytoin", "basilar invagination" ] ]

The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.

[ [ "clioquinol", "transient global amnesia" ], [ "clioquinol", "retrograde amnesia" ] ]

Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.

[ [ "sorafenib", "Interstitial pneumonia" ] ]

Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.

[ [ "sulfamethoxazole-trimethoprim", "renal tubular dysfunction" ], [ "sulfamethoxazole-trimethoprim", "Hyperkalaemia" ] ]

Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command.

[ [ "morphine", "hypotensive" ], [ "morphine", "bradypneic" ] ]

Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.

[ [ "asparaginase", "hyperglycemia" ] ]

We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.

[ [ "CHOP", "supravenous hyperpigmentation" ] ]

Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.

[ [ "Fenclofenac", "IgA deficiency" ] ]

Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.

[ [ "4-chloro-7-nitrobenzofurazan", "Allergic contact dermatitis" ] ]

Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.

[ [ "Warfarin", "bleeding" ] ]

One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.

[ [ "epinephrine", "coronary artery vasospasm" ] ]

Ampicillin-associated seizures.

[ [ "Ampicillin", "seizures" ] ]