harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.	[ [ "fluvoxamine", "increased libido" ] ]
Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.	[ [ "Levofloxacin", "toxic epidermal necrolysis" ] ]
Cimetidine-induced fever.	[ [ "Cimetidine", "fever" ] ]
Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.	[ [ "etoposide", "acute myeloid leukemia" ] ]
The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.	[ [ "docetaxel", "subacute interstitial pneumonitis-related pulmonary fibrosis" ] ]
The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.	[ [ "baclofen", "autonomic instability" ], [ "baclofen", "fever" ] ]
The exact mechanism of IVIG-associated acute renal failure remains unclear.	[ [ "IVIG", "acute renal failure" ] ]
Can magnesium sulfate therapy impact lactogenesis?	[ [ "magnesium sulfate", "lactogenesis" ] ]
Severe akathisia during olanzapine treatment of acute schizophrenia.	[ [ "olanzapine", "Severe akathisia" ] ]
Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.	[ [ "methotrexate", "Accelerated nodulosis" ] ]
A syndrome of increased affect in response to risperidone among patients with schizophrenia.	[ [ "risperidone", "syndrome of increased affect" ] ]
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.	[ [ "MTX", "extensive skin rash" ] ]
A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.	[ [ "gold", "lichen planus" ] ]
Losartan-induced angioedema.	[ [ "Losartan", "angioedema" ] ]
With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.	[ [ "minocycline", "mononucleosis-like syndrome" ] ]
The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.	[ [ "propylthiouracil", "cutaneous vasculitis" ] ]
We describe a patient who became hypothyroid while taking ferrous sulfate.	[ [ "ferrous sulfate", "hypothyroid" ] ]
Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.	[ [ "lithium", "thyroid dysfunctions" ] ]
Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.	[ [ "warfarin", "Stuttering priapism" ] ]
Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.	[ [ "chloramphenicol", "Hypersensitivity reaction" ] ]
Concomitant administration of lithium with olanzapine may place patients at risk for NMS.	[ [ "olanzapine", "NMS" ], [ "lithium", "NMS" ] ]
After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.	[ [ "methylprednisolone", "steroid diabetes" ] ]
Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.	[ [ "oxaliplatinum", "Acute lung injury" ], [ "5-fluorouracil", "Acute lung injury" ] ]
Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.	[ [ "bretylium", "fibrillation" ], [ "bretylium", "Paradoxical ventricular tachycardia" ] ]
Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.	[ [ "methamphetamine", "keratitis" ], [ "methamphetamine", "toxic effects" ], [ "lidocaine", "toxic effects" ], [ "lidocaine", "keratitis" ], [ "quinine", "keratitis" ], [ "quinine", "toxic effects" ] ]
In the third child, the tics ceased after CBZ discontinuation.	[ [ "CBZ", "tics" ] ]
The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.	[ [ "procainamide", "pro-arrhythmic effects" ] ]
Atenolol induced memory impairment: a case report.	[ [ "Atenolol", "memory impairment" ] ]
We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.	[ [ "phenylephrine", "severe hypertension" ], [ "epinephrine", "severe hypertension" ] ]
There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.	[ [ "Accutane", "transient myopia" ] ]
Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?	[ [ "Niflumic acid", "skeletal fluorosis" ] ]
Acute coronary events following cisplatin-based chemotherapy.	[ [ "cisplatin", "Acute coronary events" ] ]
A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.	[ [ "interferon alpha", "polymyositis" ], [ "interferon alpha", "dilated cardiomyopathy" ] ]
Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.	[ [ "cyclophosphamide", "Musculoskeletal complaints" ], [ "ifosfamide", "Musculoskeletal complaints" ] ]
Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.	[ [ "PRES", "Posterior reversible encephalopathy syndrome" ], [ "PRES", "cyclosporine" ] ]
Fulminant hepatitis associated with disulfiram.	[ [ "disulfiram", "Fulminant hepatitis" ] ]
We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.	[ [ "thalidomide", "sensorimotor axonal neuropathy" ] ]
We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.	[ [ "sumatriptan", "spontaneous splenic infarction" ] ]
CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.	[ [ "colchicine", "colchicine intoxication" ] ]
After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.	[ [ "esmolol hydrochloride", "asystole" ] ]
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.	[ [ "nimesulide", "renal insufficiency" ] ]
Flucloxacillin-induced aplastic anaemia and liver failure.	[ [ "Flucloxacillin", "liver failure" ], [ "Flucloxacillin", "aplastic anaemia" ] ]
We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.	[ [ "zafirlukast", "drug-drug interaction" ], [ "theophylline", "drug-drug interaction" ] ]
Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.	[ [ "Carbamazepine", "hypersensitivity syndrome" ] ]
With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.	[ [ "itraconazole", "hepatotoxic" ] ]
The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.	[ [ "aripiprazole", "unusual weight fluctuation" ], [ "mianserin", "unusual weight fluctuation" ] ]
A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.	[ [ "ifosfamide", "irreversible lethal renal failure" ], [ "ifosfamide", "anuria" ] ]
Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.	[ [ "L-asparaginase", "Pancreatitis" ] ]
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.	[ [ "granulocyte colony-stimulating factor", "Neutrophilic dermatoses" ], [ "G-CSF", "Neutrophilic dermatoses" ] ]
The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.	[ [ "clozapine", "agranulocytosis" ] ]
Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.	[ [ "gefitinib", "Interstitial lung disease" ], [ "gefitinib", "ILD" ] ]
The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.	[ [ "5-FU", "coma" ], [ "5-FU", "encephalopathy" ], [ "5-FU", "neurologic symptoms" ], [ "5-FU", "severe acute 5-FU reactions" ] ]
However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.	[ [ "linezolid", "neuropathy" ], [ "linezolid", "peripheral neuropathy" ], [ "linezolid", "bone marrow depression" ] ]
A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.	[ [ "adalimumab", "acute respiratory failure" ] ]
The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.	[ [ "PPA", "occipital infarcts" ], [ "PPA", "extremely elevated levels of PPA" ] ]
There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.	[ [ "heparin", "thrombocytopenia" ] ]
He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.	[ [ "chlorambucil", "fever" ], [ "chlorambucil", "hypereosinophilia" ], [ "chlorambucil", "acute renal failure" ], [ "chlorambucil", "skin rash" ] ]
Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.	[ [ "lithium", "thyrotoxicosis" ] ]
We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.	[ [ "morphine", "respiratory depression" ] ]
The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.	[ [ "RA", "BMTN" ] ]
Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.	[ [ "sorafenib", "interstitial lung disease" ] ]
Dipyrone-induced granulocytopenia: a case for awareness.	[ [ "Dipyrone", "granulocytopenia" ] ]
We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.	[ [ "flupirtine", "increased cerebral cortical excitability" ] ]
Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.	[ [ "ciprofloxacin", "minor dizziness" ], [ "ciprofloxacin", "mild headache" ], [ "ciprofloxacin", "seizures" ], [ "ciprofloxacin", "hallucinations" ] ]
Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.	[ [ "lorcainide", "Hyponatremia" ] ]
Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.	[ [ "propranolol", "bronchospasm" ] ]
Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.	[ [ "tiagabine", "non-convulsive status epilepticus" ] ]
Stupor and fast activity on electroencephalography in a child treated with valproate.	[ [ "valproate", "Stupor" ] ]
We conclude peripheral neuropathy with 5-FU is rare.	[ [ "5-FU", "peripheral neuropathy" ] ]
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.	[ [ "venlafaxine", "serotonin syndrome" ], [ "venlafaxine", "extrapyramidal movement disorders" ], [ "sertraline", "extrapyramidal movement disorders" ], [ "metoclopramide", "serotonin syndrome" ], [ "metoclopramide", "extrapyramidal movement disorders" ], [ "sertraline", "serotonin syndrome" ] ]
Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.	[ [ "acetylsalicylic acid", "Pericardial hemorrhage" ] ]
During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.	[ [ "IFN", "IDDM" ] ]
This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.	[ [ "flucytosine", "ulcerating enteritis" ], [ "flucytosine", "severe luminal narrowing" ], [ "flucytosine", "marked separation of loops of bowel" ], [ "flucytosine", "ulceration" ] ]
A case of mania associated with fluoxetine.	[ [ "fluoxetine", "mania" ] ]
Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.	[ [ "mycophenolate mofetil", "CNS lymphoma" ] ]
Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.	[ [ "timolol", "Severe hyperkalemia" ] ]
Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.	[ [ "amiodarone", "thyrotoxicosis" ], [ "amiodarone", "hypothyroidism" ], [ "amiodarone", "Goiter" ] ]
This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.	[ [ "vecuronium", "respiratory failure" ] ]
The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.	[ [ "acetylsalicylic acid", "pericardial hemorrhage" ] ]
Hepatotoxic effects in a child receiving valproate and carnitine.	[ [ "valproate", "Hepatotoxic effects" ], [ "carnitine", "Hepatotoxic effects" ] ]
Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.	[ [ "prednisone", "disseminated histoplasmosis" ] ]
Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.	[ [ "cisplatin", "colitis" ] ]
A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.	[ [ "valproate", "abnormal posture of extreme forward flexion" ], [ "valproate", "camptocormia" ] ]
The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.	[ [ "niacin", "pain to the teeth" ], [ "niacin", "prostaglandin-mediated vasodilatation" ], [ "niacin", "hyperalgesia of sensory nerve receptors" ], [ "niacin", "potentiation of inflammation in the gingiva" ] ]
RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.	[ [ "carboplatin", "platinum hypersensitivity" ] ]
We suggest discontinuing gemcitabine if radiation recall is observed.	[ [ "gemcitabine", "radiation recall" ] ]
She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.	[ [ "doxorubicin", "died" ], [ "doxorubicin", "Adriamycin toxicity" ], [ "Adriamycin", "Adriamycin toxicity" ], [ "Adriamycin", "died" ] ]
Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.	[ [ "isradipine", "hepatocellular injury" ] ]
Penicillin-induced Jarisch-Herxheimer reaction.	[ [ "Penicillin", "Jarisch-Herxheimer reaction" ] ]
Two patients on long-term lithium therapy developed the nephrotic syndrome.	[ [ "lithium", "nephrotic syndrome" ] ]
In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.	[ [ "lithium", "teratogenicity" ], [ "lithium", "Epstein's anomaly" ] ]
Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.	[ [ "imipenem", "Proconvulsive" ], [ "cilastatin", "Proconvulsive" ] ]
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.	[ [ "ifosfamide", "ifosfamide-induced encephalopathy" ] ]
We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).	[ [ "HOPA", "acute encephalopathy" ], [ "calcium hopantenate", "acute encephalopathy" ] ]
This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.	[ [ "clindamycin", "ductopenia" ] ]
We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.	[ [ "isoniazid", "psychotic disorder" ] ]
In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.	[ [ "prostaglandin E1", "harlequin color change" ] ]
A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.	[ [ "amphotericin B", "EEG abnormalities" ], [ "amphotericin B", "acute toxic delirium" ] ]
Severe neurotoxicity with methyl G: CALGB experience.	[ [ "methyl G: CALGB", "Severe neurotoxicity" ] ]
Falling backward in two elderly patients taking bupropion.	[ [ "bupropion", "Falling backward" ] ]

RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.

[ [ "fluvoxamine", "increased libido" ] ]

Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.

[ [ "Levofloxacin", "toxic epidermal necrolysis" ] ]

Cimetidine-induced fever.

[ [ "Cimetidine", "fever" ] ]

Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.

[ [ "etoposide", "acute myeloid leukemia" ] ]

The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.

[ [ "docetaxel", "subacute interstitial pneumonitis-related pulmonary fibrosis" ] ]

The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.

[ [ "baclofen", "autonomic instability" ], [ "baclofen", "fever" ] ]

The exact mechanism of IVIG-associated acute renal failure remains unclear.

[ [ "IVIG", "acute renal failure" ] ]

Can magnesium sulfate therapy impact lactogenesis?

[ [ "magnesium sulfate", "lactogenesis" ] ]

Severe akathisia during olanzapine treatment of acute schizophrenia.

[ [ "olanzapine", "Severe akathisia" ] ]

Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.

[ [ "methotrexate", "Accelerated nodulosis" ] ]

A syndrome of increased affect in response to risperidone among patients with schizophrenia.

[ [ "risperidone", "syndrome of increased affect" ] ]

Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.

[ [ "MTX", "extensive skin rash" ] ]

A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.

[ [ "gold", "lichen planus" ] ]

Losartan-induced angioedema.

[ [ "Losartan", "angioedema" ] ]

With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.

[ [ "minocycline", "mononucleosis-like syndrome" ] ]

The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.

[ [ "propylthiouracil", "cutaneous vasculitis" ] ]

We describe a patient who became hypothyroid while taking ferrous sulfate.

[ [ "ferrous sulfate", "hypothyroid" ] ]

Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.

[ [ "lithium", "thyroid dysfunctions" ] ]

Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.

[ [ "warfarin", "Stuttering priapism" ] ]

Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.

[ [ "chloramphenicol", "Hypersensitivity reaction" ] ]

Concomitant administration of lithium with olanzapine may place patients at risk for NMS.

[ [ "olanzapine", "NMS" ], [ "lithium", "NMS" ] ]

After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.

[ [ "methylprednisolone", "steroid diabetes" ] ]

Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.

[ [ "oxaliplatinum", "Acute lung injury" ], [ "5-fluorouracil", "Acute lung injury" ] ]

Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.

[ [ "bretylium", "fibrillation" ], [ "bretylium", "Paradoxical ventricular tachycardia" ] ]

Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.

[ [ "methamphetamine", "keratitis" ], [ "methamphetamine", "toxic effects" ], [ "lidocaine", "toxic effects" ], [ "lidocaine", "keratitis" ], [ "quinine", "keratitis" ], [ "quinine", "toxic effects" ] ]

In the third child, the tics ceased after CBZ discontinuation.

[ [ "CBZ", "tics" ] ]

The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.

[ [ "procainamide", "pro-arrhythmic effects" ] ]

Atenolol induced memory impairment: a case report.

[ [ "Atenolol", "memory impairment" ] ]

We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.

[ [ "phenylephrine", "severe hypertension" ], [ "epinephrine", "severe hypertension" ] ]

There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.

[ [ "Accutane", "transient myopia" ] ]

Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?

[ [ "Niflumic acid", "skeletal fluorosis" ] ]

Acute coronary events following cisplatin-based chemotherapy.

[ [ "cisplatin", "Acute coronary events" ] ]

A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.

[ [ "interferon alpha", "polymyositis" ], [ "interferon alpha", "dilated cardiomyopathy" ] ]

Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.

[ [ "cyclophosphamide", "Musculoskeletal complaints" ], [ "ifosfamide", "Musculoskeletal complaints" ] ]

Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.

[ [ "PRES", "Posterior reversible encephalopathy syndrome" ], [ "PRES", "cyclosporine" ] ]

Fulminant hepatitis associated with disulfiram.

[ [ "disulfiram", "Fulminant hepatitis" ] ]

We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.

[ [ "thalidomide", "sensorimotor axonal neuropathy" ] ]

We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.

[ [ "sumatriptan", "spontaneous splenic infarction" ] ]

CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

[ [ "colchicine", "colchicine intoxication" ] ]

After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.

[ [ "esmolol hydrochloride", "asystole" ] ]

Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.

[ [ "nimesulide", "renal insufficiency" ] ]

Flucloxacillin-induced aplastic anaemia and liver failure.

[ [ "Flucloxacillin", "liver failure" ], [ "Flucloxacillin", "aplastic anaemia" ] ]

We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.

[ [ "zafirlukast", "drug-drug interaction" ], [ "theophylline", "drug-drug interaction" ] ]

Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.

[ [ "Carbamazepine", "hypersensitivity syndrome" ] ]

With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.

[ [ "itraconazole", "hepatotoxic" ] ]

The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.

[ [ "aripiprazole", "unusual weight fluctuation" ], [ "mianserin", "unusual weight fluctuation" ] ]

A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.

[ [ "ifosfamide", "irreversible lethal renal failure" ], [ "ifosfamide", "anuria" ] ]

Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.

[ [ "L-asparaginase", "Pancreatitis" ] ]

Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.

[ [ "granulocyte colony-stimulating factor", "Neutrophilic dermatoses" ], [ "G-CSF", "Neutrophilic dermatoses" ] ]

The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.

[ [ "clozapine", "agranulocytosis" ] ]

Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.

[ [ "gefitinib", "Interstitial lung disease" ], [ "gefitinib", "ILD" ] ]

The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.

[ [ "5-FU", "coma" ], [ "5-FU", "encephalopathy" ], [ "5-FU", "neurologic symptoms" ], [ "5-FU", "severe acute 5-FU reactions" ] ]

However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.

[ [ "linezolid", "neuropathy" ], [ "linezolid", "peripheral neuropathy" ], [ "linezolid", "bone marrow depression" ] ]

A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described.

[ [ "adalimumab", "acute respiratory failure" ] ]

The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.

[ [ "PPA", "occipital infarcts" ], [ "PPA", "extremely elevated levels of PPA" ] ]

There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.

[ [ "heparin", "thrombocytopenia" ] ]

He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.

[ [ "chlorambucil", "fever" ], [ "chlorambucil", "hypereosinophilia" ], [ "chlorambucil", "acute renal failure" ], [ "chlorambucil", "skin rash" ] ]

Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.

[ [ "lithium", "thyrotoxicosis" ] ]

We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.

[ [ "morphine", "respiratory depression" ] ]

The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.

[ [ "RA", "BMTN" ] ]

Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.

[ [ "sorafenib", "interstitial lung disease" ] ]

Dipyrone-induced granulocytopenia: a case for awareness.

[ [ "Dipyrone", "granulocytopenia" ] ]

We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.

[ [ "flupirtine", "increased cerebral cortical excitability" ] ]

Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.

[ [ "ciprofloxacin", "minor dizziness" ], [ "ciprofloxacin", "mild headache" ], [ "ciprofloxacin", "seizures" ], [ "ciprofloxacin", "hallucinations" ] ]

Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.

[ [ "lorcainide", "Hyponatremia" ] ]

Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.

[ [ "propranolol", "bronchospasm" ] ]

Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.

[ [ "tiagabine", "non-convulsive status epilepticus" ] ]

Stupor and fast activity on electroencephalography in a child treated with valproate.

[ [ "valproate", "Stupor" ] ]

We conclude peripheral neuropathy with 5-FU is rare.

[ [ "5-FU", "peripheral neuropathy" ] ]

OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.

[ [ "venlafaxine", "serotonin syndrome" ], [ "venlafaxine", "extrapyramidal movement disorders" ], [ "sertraline", "extrapyramidal movement disorders" ], [ "metoclopramide", "serotonin syndrome" ], [ "metoclopramide", "extrapyramidal movement disorders" ], [ "sertraline", "serotonin syndrome" ] ]

Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.

[ [ "acetylsalicylic acid", "Pericardial hemorrhage" ] ]

During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.

[ [ "IFN", "IDDM" ] ]

This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.

[ [ "flucytosine", "ulcerating enteritis" ], [ "flucytosine", "severe luminal narrowing" ], [ "flucytosine", "marked separation of loops of bowel" ], [ "flucytosine", "ulceration" ] ]

A case of mania associated with fluoxetine.

[ [ "fluoxetine", "mania" ] ]

Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.

[ [ "mycophenolate mofetil", "CNS lymphoma" ] ]

Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.

[ [ "timolol", "Severe hyperkalemia" ] ]

Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.

[ [ "amiodarone", "thyrotoxicosis" ], [ "amiodarone", "hypothyroidism" ], [ "amiodarone", "Goiter" ] ]

This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.

[ [ "vecuronium", "respiratory failure" ] ]

The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.

[ [ "acetylsalicylic acid", "pericardial hemorrhage" ] ]

Hepatotoxic effects in a child receiving valproate and carnitine.

[ [ "valproate", "Hepatotoxic effects" ], [ "carnitine", "Hepatotoxic effects" ] ]

Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.

[ [ "prednisone", "disseminated histoplasmosis" ] ]

Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.

[ [ "cisplatin", "colitis" ] ]

A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.

[ [ "valproate", "abnormal posture of extreme forward flexion" ], [ "valproate", "camptocormia" ] ]

The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.

[ [ "niacin", "pain to the teeth" ], [ "niacin", "prostaglandin-mediated vasodilatation" ], [ "niacin", "hyperalgesia of sensory nerve receptors" ], [ "niacin", "potentiation of inflammation in the gingiva" ] ]

RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.

[ [ "carboplatin", "platinum hypersensitivity" ] ]

We suggest discontinuing gemcitabine if radiation recall is observed.

[ [ "gemcitabine", "radiation recall" ] ]

She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.

[ [ "doxorubicin", "died" ], [ "doxorubicin", "Adriamycin toxicity" ], [ "Adriamycin", "Adriamycin toxicity" ], [ "Adriamycin", "died" ] ]

Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.

[ [ "isradipine", "hepatocellular injury" ] ]

Penicillin-induced Jarisch-Herxheimer reaction.

[ [ "Penicillin", "Jarisch-Herxheimer reaction" ] ]

Two patients on long-term lithium therapy developed the nephrotic syndrome.

[ [ "lithium", "nephrotic syndrome" ] ]

In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.

[ [ "lithium", "teratogenicity" ], [ "lithium", "Epstein's anomaly" ] ]

Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.

[ [ "imipenem", "Proconvulsive" ], [ "cilastatin", "Proconvulsive" ] ]

Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.

[ [ "ifosfamide", "ifosfamide-induced encephalopathy" ] ]

We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).

[ [ "HOPA", "acute encephalopathy" ], [ "calcium hopantenate", "acute encephalopathy" ] ]

This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.

[ [ "clindamycin", "ductopenia" ] ]

We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.

[ [ "isoniazid", "psychotic disorder" ] ]

In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.

[ [ "prostaglandin E1", "harlequin color change" ] ]

A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.

[ [ "amphotericin B", "EEG abnormalities" ], [ "amphotericin B", "acute toxic delirium" ] ]

Severe neurotoxicity with methyl G: CALGB experience.

[ [ "methyl G: CALGB", "Severe neurotoxicity" ] ]

Falling backward in two elderly patients taking bupropion.

[ [ "bupropion", "Falling backward" ] ]