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pair_32803908 | Few studies have investigated the effects of essential fatty acids on the production of epidermal ceramide (CER) in canine keratinocytes. To investigate the effects of eicosapentaenoic acid (EPA) and linoleic acid (LA) supplementation on the production of CERs using an in vitro canine keratinocyte culture system. Canin... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Poucos estudos investigaram os efeitos dos ácidos graxos essenciais na produção de ceramida epidérmica (CER) em queratinócitos caninos. HIPÓTESE/OBJETIVOS: Investigar os efeitos da suplementação com ácido eicosapentaenóico (EPA) e ácido linoléico (LA) na produção de CERs utilizando um sistema de cultura de queratinócit... | pt |
pair_32803908 | Few studies have investigated the effects of essential fatty acids on the production of epidermal ceramide (CER) in canine keratinocytes. To investigate the effects of eicosapentaenoic acid (EPA) and linoleic acid (LA) supplementation on the production of CERs using an in vitro canine keratinocyte culture system. Canin... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | pocos estudios han investigado los efectos de los ácidos grasos esenciales en la producción de ceramida epidérmica (CER) en los queratinocitos caninos. HIPÓTESIS/OBJETIVOS: investigar los efectos de la suplementación con ácido eicosapentaenoico (EPA) y ácido linoleico (LA) en la producción de CER utilizando un sistema ... | es |
pair_33817790 | An increasing body of work documents the roles of religion and spirituality in Black American marriages. We built on this research to examine religious coping as a potential cultural resource for Black marriages using a dyadic analytic approach with longitudinal data. Specifically, we investigated the effects of positi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 有越来越多的研究记录了宗教和精神信仰在美国黑人婚姻中的作用。本研究利用长期研究的数据为基础进行二元分析，研究宗教应对作为黑人婚姻的潜在文化资本。具体来说，我们调查了积极的（即精神联系感）和消极的（即精神紧张或斗争）宗教应对，有161对黑人、已婚、男女异性夫妇的妻子和丈夫参与本研究，他们报告的婚姻爱情轨迹受宗教应对的影响。我们测试了配偶性别的潜在调节作用。在基线阶段，配偶报告了他们的宗教应对方式，他们对他们的婚姻爱情进行了基线评估，并在每年进行的另外两次家庭调查中进行了评估。在行为者-伴侣相互依存模型框架内，使用增长曲线模型对数据进行分析。那些在基线时报告了更积极的宗教应对方式的丈夫随着时间的推移表现出相对较高和稳定的婚姻爱情，而那些... | zh-cn |
pair_33817790 | An increasing body of work documents the roles of religion and spirituality in Black American marriages. We built on this research to examine religious coping as a potential cultural resource for Black marriages using a dyadic analytic approach with longitudinal data. Specifically, we investigated the effects of positi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Cada vez más investigaciones documentan los papeles que desempeñan la religión y la espiritualidad en los matrimonios afroestadounidenses. Utilizamos estas investigaciones como punto de partida para analizar el afrontamiento religioso como posible recurso cultural para los matrimonios de color usando un método analític... | es |
pair_33819964 | Perioperative treatment has become an increasingly important aspect of the management of patients with non-small cell lung cancer (NSCLC). Small-scale clinical studies performed in recent years have shown improvements in the major pathological remission rate after neoadjuvant therapy, suggesting that it will soon becom... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：非小细胞肺癌围手术期免疫治疗
相关不良反应管理的临床诊疗建议】 【中文摘要：背景与目的 肺癌围手术期治疗（术前新辅助治疗及术后辅助治疗）作为手术的重要辅助手段，已成为非小细胞肺癌（non-small cell lung cancer, NSCLC）全程管理中越来越重要的环节。近年来，小规模临床研究发现免疫新辅助治疗主要病理缓解率明显提升，甚至达到完全病理缓解，有望成为NSCLC治疗的重要组成部分。然而，免疫新辅助治疗带来疗效和生存获益，同时，其相关严重不良反应（延误手术、丧失手术机会、死亡等）备受关注。本诊疗建议目的是针对免疫检查点抑制剂相关不良反应（immune-related adverse event, irAE）... | zh-cn |
pair_33819966 | Among malignant tumors, lung cancer has the highest mortality rate. Small cell lung cancer (SCLC) is a kind of malignant lung cancer. Its doubling time is very fast. Patients are prone to drug resistance during treatment, and their condition often deteriorates rapidly after recurrence. Except for topotecan, there is a ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：伊立替康二线治疗难治性复发小细胞肺癌的疗效分析】 【中文摘要：背景与目的 肺癌死亡率在恶性肿瘤中高居首位，小细胞肺癌（small cell lung cancer, SCLC）是肺癌恶性程度最高的一种，其倍增时间短，患者在治疗过程中易发生迅速耐药，且复发后病情迅速恶化。目前除拓扑替康外，缺乏有效的二线单药化疗方案。本研究旨在探究伊立替康（irinotecan, CPT-11）二线单药治疗难治性复发SCLC的疗效及安全性。方法 收集吉林国文医院肿瘤内科2012年4月-2020年3月确诊的一线治疗后6个月内复发的经单药CPT-11二线化疗的SCLC患者107例，末次随访至2020年11月。记录患者的无进展生存时间（progr... | zh-cn |
pair_33819965 | Immunotherapy represented by immune checkpoint inhibitors (ICIs) has been widely used in the treatment of lung cancer. There are controversies in clinical practice for patients with advanced non-small cell lung cancer (NSCLC) and high programmed cell death-ligand 1 (PD-L1) expression receiving ICIs monotherapy or combi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：PD-L1高表达晚期非小细胞肺癌患者
单纯免疫治疗与免疫联合化疗疗效比较】 【中文摘要：背景与目的 以免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）为代表的免疫治疗越来越广泛地应用于肺癌治疗。然而，对于程序性死亡受体配体1（programmed cell death-ligand 1, PD-L1）高表达，即肿瘤比例评分（tumor proportion score, TPS）≥50%的晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）患者，采用单纯免疫治疗还是免疫联合化疗在临床上仍存争议。本研究旨在评估PD-L1高表达的晚期NSCLC患者接受... | zh-cn |
pair_33819968 | The aim of this study is to investigate the changes of peripheral blood lymphocyte subsets before and after treatment with pembrolizumab for non-small cell lung cancer and its clinical significance. A total of 32 patients with non-small cell lung cancer who received pembrolizumab treatment in The Affiliated Hospital of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：帕博利珠单抗对晚期非小细胞肺癌患者
T淋巴细胞亚群的影响及疗效观测】 【中文摘要：背景与目的 本研究旨在探究非小细胞肺癌患者应用帕博利珠单抗治疗前后外周血淋巴细胞亚群的变化及临床意义。方法 选取2015年1月-2020年12月至青岛大学附属医院及潍坊市人民医院行帕博利珠单抗治疗的32例非小细胞肺癌的患者为观察组，另外选取同期30例健康查体者为对照组。治疗前、治疗后第1、2、4周期，采用流体细胞术检测患者外周血淋巴细胞亚群水平的变化。结果 非小细胞肺癌患者治疗前的CD3⁺、CD4⁺、CD4⁺/CD8⁺指标较对照组明显下降（P<0.05），CD8⁺水平明显升高（P<0.05）；应用帕博利珠单抗治疗1个周期后，淋巴细胞亚群较免... | zh-cn |
pair_33819969 | With the development of precise medicine, targeted therapy has greatly improved the survival and prognosis of patients in advanced non-small cell lung cancer (NSCLC) with oncogenic drivers. However, no matter which kinds of targeted therapy are inevitable to develop therapeutic resistance, treatment options upon exhaus... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：免疫检查点抑制剂在驱动基因阳性
晚期非小细胞肺癌中的应用进展】 【中文摘要：随着肿瘤精准医学的发展，驱动基因阳性非小细胞肺癌（non-small cell lung cancer, NSCLC）患者接受靶向治疗极大地改善了生存和预后，但不管是哪代靶向药物均不可避免的会经历耐药，患者会面临无靶可用的局面。免疫检查点抑制剂因其特有的长拖尾效应，能给部分晚期NSCLC患者带来长生存。越来越多的研究显示免疫治疗同样可为部分驱动基因阳性NSCLC患者带来获益，但免疫治疗介入的时机、治疗方案的选择以及预测生物标记物等问题仍不十分明确，值得进一步探讨。
】 【中文关键词：肺肿瘤；驱动基因；免疫检查点抑制剂；预测】. | zh-cn |
pair_33819970 | Lung cancer has the highest incidence rate and mortality in China, even in the world, and non-small cell lung cancer (NSCLC) accounts for about 85%. The growth and metastasis of tumor depend on the generation of blood vessels, and anti-angiogenic therapy is playing an increasingly important role, however, no significan... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：抗血管生成药物联合免疫检查点抑制剂
治疗晚期非小细胞肺癌的研究进展】 【中文摘要：肺癌是中国乃至全世界发病率和死亡率最高的癌种，其中非小细胞肺癌（non-small cell lung cancer, NSCLC）约占85%。肿瘤的生长和转移依赖于肿瘤新生血管的形成，抗血管生成治疗的地位日益显著，但仅接受抗血管生成单药治疗无法使患者预后明显改善。近年来，免疫检查点抑制剂（immune checkpoint inhibitor, ICI）的应用显著地改善了部分肺癌患者的预后，但接受ICI单药治疗人群的缓解率较低，而抗血管生成药物和免疫检查点抑制剂均能调节肿瘤微环境、有潜在协同作用机制，联合应用于抗肿瘤治疗有较好前景。本文将... | zh-cn |
pair_33819971 | Immunotherapy is one of the main strategies of anti-tumor therapy at present, in which immune checkpoint inhibitors (ICIs) are the most widely used drug. ICIs resistance is mediated by a variety of cytokines and immune cells, and the mechanism is complex, which is the main reason for the failure of immunotherapy in can... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：组蛋白去乙酰化酶抑制剂联合免疫检查点
抑制剂治疗肿瘤的研究进展】 【中文摘要：免疫治疗是目前抗肿瘤治疗的主要策略之一，其中免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）是研究应用最为广泛的一类药物。ICIs耐药由多种细胞因子及免疫细胞介导，机制复杂，是造成癌症患者免疫治疗失败的主要原因。组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitor, HDACi）作为一类表观遗传调控药物，在调控细胞周期、增殖分化及活性中发挥重要作用。近年来，研究发现HDACi不仅能够调节细胞生物学特征，还与肿瘤ICIs耐药的改善密切相关。因此，HDACi提高ICIs疗效的相关... | zh-cn |
pair_33819972 | Tumor microenvironment (TME) is a dynamic network distributed around tumor cells. Cancer-associated fibroblasts (CAFs), as an important component of the TME, are not only closely related to normal fibroblasts, but also can secrete a variety of substances to participate in the regulation of the TME. Exosomes, one of the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：癌相关成纤维细胞来源的外泌体
在肺恶性肿瘤中的研究进展】 【中文摘要：肿瘤微环境（tumor microenvironment, TME）是分布在肿瘤细胞周围的动态网络，癌相关成纤维细胞（cancer-associated fibroblasts, CAFs）作为肿瘤微环境中的一部分，不但与正常成纤维细胞密切相关，而且可以分泌多种物质（包括外泌体）参与肿瘤微环境的调控。外泌体不仅与肺恶性肿瘤微环境形成密切相关，同时其可增加肺癌细胞侵袭与转移能力，对肿瘤免疫抑制有介导作用，还参与肺癌患者接受放化疗后耐药的机制中。本文就CAFs来源相关外泌体在肺癌中的研究现状和进展做一综述。
】 【中文关键词：肿瘤微环境；癌相关成纤维细胞；... | zh-cn |
pair_33821064 | Following the COVID-19 pandemic, psychological therapies rapidly moved online in mid-2020. The Association for Family Therapy and Systemic Practice in the UK (AFT) surveyed the attitudes and practices of systemic therapists in the UK in early October 2020, exploring members' views and gathered information about ongoing... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在新冠肺炎大流行之后，心理治疗迅速在2020年中期转到线上。英国家庭治疗和系统实践协会（AFT）于2020年10月初对英国系统治疗师的态度和实践进行了调查，探讨了成员的观点，并收集了有关持续存在的需求的信息。采用混合方法分析了312个样本。65%的受访者认为他们在工作中使用在线视频技术的总体体验是积极的，这进一步反映在对两个开放式问题的回答中。详细的主题分析显示，许多正面评论与线上工作的实际优势有关，而许多负面评论与技术和治疗关系有关。本文讨论了受访者可能存在的偏见，并探讨了实践当中这种变化的含义。在我们探索新技术的潜力时，这是否标志着我们的领域开始了一个更持久的转变，还有待观察。. 绝大多数英国系统治疗师认为他们线上视频技术的体验... | zh-cn |
pair_33821064 | Following the COVID-19 pandemic, psychological therapies rapidly moved online in mid-2020. The Association for Family Therapy and Systemic Practice in the UK (AFT) surveyed the attitudes and practices of systemic therapists in the UK in early October 2020, exploring members' views and gathered information about ongoing... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Después de la pandemia de COVID‐19, las terapias psicológicas se cambiaron rápidamente a formato online a mediados de 2020. La Asociación para la Terapia Familiar y la Práctica Sistémica en el Reino Unido (AFT) encuestó las actitudes y prácticas de los terapeutas sistémicos en el Reino Unido a principios de octubre de ... | es |
pair_33821065 | The COVID-19 pandemic has affected the mental health of individuals, along with their couple and familial relationships, necessitating an effective response. Teletherapy offers an option to address these relationship concerns amidst pandemic-specific mobility restriction. Against this setting, Sukoon, a project of Tata... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 新冠肺炎大流行已经影响到个人的心理健康以及他们的伴侣和家庭关系，因此需要有效应对措施。远程治疗提供了一个在疫情特有的流动性受限情况中解决这些关系问题的选择。在这种背景下，印度Tata社会科学研究所的一个项目Sukoon发起了一个针对关系健康的、五期的线上心理教育小组系列活动。本文以会面记录和辅助者笔记为基础，探讨辅助者的反思和学习。为线上心理教育小组做好准备和仔细挑选参与者是成功的关键。通过灵活调整治疗过程（教育和互动元素）以适应线上实施和文化背景，使有效性得以提高。发现关系健康线上心理教育小组的潜力，可以使其成为新冠肺炎流行病心理健康应急工具包的一个有价值的补充。. 有效准备和精心挑选小组成员是有治疗师协助的线上心理教育小组取得成... | zh-cn |
pair_33821065 | The COVID-19 pandemic has affected the mental health of individuals, along with their couple and familial relationships, necessitating an effective response. Teletherapy offers an option to address these relationship concerns amidst pandemic-specific mobility restriction. Against this setting, Sukoon, a project of Tata... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La pandemia de COVID‐19 ha afectado la salud mental de las personas, junto con sus relaciones familiares y de pareja, lo que requiere una respuesta eficaz. La teleterapia ofrece una opción para abordar estos problemas de relación en medio de la restricción de movilidad específica de una pandemia. En este contexto, Suko... | es |
pair_33821522 | The aim of the present work was to describe a case of recurrent capillary haemangioma at the coronary border of the left front limb in a 6-month-old thoroughbred filly successfully treated with diode laser ablation and adjunctive laser photocoagulation therapy. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 本研究的目的是描述一例6个月大的纯种马, 通过二极管激光消融和辅助激光光凝疗法,成功治疗左前肢冠状动脉边缘复发性毛细血管瘤的病例。. | zh-cn |
pair_33821522 | The aim of the present work was to describe a case of recurrent capillary haemangioma at the coronary border of the left front limb in a 6-month-old thoroughbred filly successfully treated with diode laser ablation and adjunctive laser photocoagulation therapy. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Le but de cette étude était de décrire un cas d’hémangione capillaire récidivant du bord coronaire du membre antérieur gauche chez un cheval de race de 6 mois traité avec succès par une ablation au laser diode et traitement adjuvant de photo-coagulation au laser. | fr |
pair_33821522 | The aim of the present work was to describe a case of recurrent capillary haemangioma at the coronary border of the left front limb in a 6-month-old thoroughbred filly successfully treated with diode laser ablation and adjunctive laser photocoagulation therapy. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Das Ziel der präsentierten Arbeit war es, den Fall eines wiederkehrenden kapillären Hämangioms am Kronrand des linken Vorderbeines bei einem 6-Monate alten Vollblutfohlen zu beschreiben, welches mittels Diodenlaserablation und darauffolgender Laser Photocoagulationstherapie erfolgreich behandelt wurde. | de |
pair_33821522 | The aim of the present work was to describe a case of recurrent capillary haemangioma at the coronary border of the left front limb in a 6-month-old thoroughbred filly successfully treated with diode laser ablation and adjunctive laser photocoagulation therapy. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | O objetivo do presente trabalho foi descrever um caso de hemangioma capilar recorrente na borda coronária do membro anterior esquerdo de uma potra de seis meses de idade, da raça Puro Sangue Inglês, tratado satisfatoriamente com ablação a laser de diodo e terapia adjuvante com fotocoagulação a laser. | pt |
pair_33821522 | The aim of the present work was to describe a case of recurrent capillary haemangioma at the coronary border of the left front limb in a 6-month-old thoroughbred filly successfully treated with diode laser ablation and adjunctive laser photocoagulation therapy. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El objetivo del presente trabajo fue describir un caso de hemangioma capilar recurrente en el borde coronario de la extremidad anterior izquierda en una potra pura sangre de 6 meses tratada con éxito con ablación con láser de diodo y terapia de fotocoagulación con láser complementaria. | es |
pair_33825344 | Acupuncture is characterized by the insertion of a fine metal needle through the skin of the human body at an acupuncture point (acupoint) in Traditional Chinese Medicine (TCM). It is an ancient form of therapy, and has a long history of prosperity and decline. Due to the persistent efforts of TCM practitioners, a numb... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 针灸是一种古老的中医治疗方式, 有着悠久的兴衰历史, 其特点是将细金属针刺入人体皮肤上特点的穴位。由于中医从业者的不懈努力, 在过去的十年中发表了许多精心设计的针灸临床试验。此外, 还开展了大量旨在揭示针灸作用机制的基础研究。为了解释神秘的中医理论, 人们已经获得了一些科学的解释。本文简要介绍了针灸的历史、现状、证据和作用机制。. | zh-cn |
pair_33826183 | Near-term ecological forecasting has the potential to mitigate negative impacts of human modifications on wildlife by directing efficient action through relevant and timely predictions. We used the U.S. avian migration system to highlight ecological forecasting applications for aeroconservation. We used millions of obs... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【摘要】 短期生态预测可以提供及时的相关预测来指导有效的行动, 从而减轻人类改造自然对野生动物造成的负面影响。本研究利用美国鸟类迁徙系统, 展示了生态预测在鸟类飞行保护方面的应用。我们利用 143 个气象监视雷达的数百万次观测, 构建并评估了一个针对美国境内鸟类夜间迁徙的迁徙预测系统。根据对迁徙活动的动态预测, 我们确定了鸟类迁徙所需夜晚的天数, 从而可以降低春秋季节通过特定地区 50%候鸟面临的空中危害的风险。我们还研究了另一种替代方法, 它采用基于时间窗口的固定保护策略, 可以覆盖历史上50%的迁徙通道。我们在实践中发现, 春秋两季, 基于动态预报的所有位点需要采取保护行动的夜晚数都比基于固定窗口选择所需的夜晚数要少 (春季平均... | zh-cn |
pair_33826183 | Near-term ecological forecasting has the potential to mitigate negative impacts of human modifications on wildlife by directing efficient action through relevant and timely predictions. We used the U.S. avian migration system to highlight ecological forecasting applications for aeroconservation. We used millions of obs... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La estimación ecológica a corto plazo tiene el potencial para mitigar los impactos negativos de las modificaciones humanas sobre la fauna al dirigir las acciones eficientes mediante predicciones relevantes y oportunas. Usamos el sistema de migración de aves de Estados Unidos para resaltar las aplicaciones de la estimac... | es |
pair_33830510 | To quantify the impact of the COVID-19 pandemic and public health interventions on parent and child mental health and family relationships, we examined change in individual and family functioning in a sample of parents enrolled in a prevention trial; we examined change before the pandemic (2017-2019) when children were... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 本文把COVID-19和公共健康干预措施对父母和儿童的心理健康以及对家庭关系的影响进行量化，对参加一项预防试验的人群样本进行了研究，主要关于这些受试父母的个体功能和家庭功能产生了哪些变化; 我们采用配对t检验和HLM模型，研究了新冠肺炎(2017-2019年)前的变化，即平均年龄为7岁的儿童至美国实施广泛公共健康干预措施(2020年)后的第一个月。我们通过父母性别、教育程度、家庭收入和养育子女的冲突来考察这些因素的调适作用。我们发现，儿童对很多问题以及父母的抑郁表现都进行内化和外化，从新冠肺炎流行发生前到新冠大流行的头几个月出现了严重恶化倾向，亲子教育的质量略有下降。父母的焦虑和培养孩子方面的质量也有较小的变化。收入水平较低的母亲和... | zh-cn |
pair_33830510 | To quantify the impact of the COVID-19 pandemic and public health interventions on parent and child mental health and family relationships, we examined change in individual and family functioning in a sample of parents enrolled in a prevention trial; we examined change before the pandemic (2017-2019) when children were... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Para cuantificar el efecto de la pandemia de la COVID-19 y de las intervenciones de salud pública en la salud mental de los padres y los niños y en las relaciones familiares, analizamos los cambios en el funcionamiento individual y familiar en una muestra de padres inscriptos en un ensayo de prevención; estudiamos el c... | es |
pair_33830550 | Some dogs with chronic otitis externa (OE) develop proliferation of the tissues surrounding the opening of the external ear canal, resulting in obstruction. Traditionally total ear canal ablation with bulla osteotomy (TECABO) has been recommended. To evaluate the efficacy of a novel treatment using carbon dioxide (CO<s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 一些慢性外耳炎(OE)患犬存在耳道开口周围组织增生, 导致阻塞。传统上推荐采用骨泡截骨术(TECABO)进行全耳道消融。 目的: 评价使用二氧化碳(CO2)激光手术的新型治疗的疗效, 并描述慢性增生性和阻塞性OE的组织病理学特征。 动物: 纳入了26只犬, 16只为双侧, 10只为单侧发病 (治疗了42个耳道) 。排除水平耳道不通畅或耳道肉眼可见钙化的犬。从11只犬 (17个耳道) 中采集组织样本进行组织病理学评价。 方法和材料: 使用CO2激光切除和和消融耳道开口周围和垂直耳道内的增生组织。评价活检样本的皮脂腺和耵聍腺增生、表皮增生、炎症和纤维化。 结果: CO2激光手术后, 26只犬中的24只的42个耳道中, 有39个的... | zh-cn |
pair_33830550 | Some dogs with chronic otitis externa (OE) develop proliferation of the tissues surrounding the opening of the external ear canal, resulting in obstruction. Traditionally total ear canal ablation with bulla osteotomy (TECABO) has been recommended. To evaluate the efficacy of a novel treatment using carbon dioxide (CO<s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Des chiens avec otite externe chronique (OE) développent des proliférations des tissus entourant l’ouverture du conduit auriculaire externe résultant en une obstruction. Une ablation totale du conduit auriculaire avec ostéotomie (TECABO) est traditionnellement recommandée. Evaluer l’efficacité d’un nouveau traitement u... | fr |
pair_33830550 | Some dogs with chronic otitis externa (OE) develop proliferation of the tissues surrounding the opening of the external ear canal, resulting in obstruction. Traditionally total ear canal ablation with bulla osteotomy (TECABO) has been recommended. To evaluate the efficacy of a novel treatment using carbon dioxide (CO<s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Einige Hunde mit einer chronischen Otitis Externa (OE) entwickeln eine Proliferation der Gewebe, die die Öffnung des äußeren Gehörgangs umgeben, was in einer Obstruktion endet. Traditionellerweise wurde dann eine totale Ohrkanalablation mit einer Bulla Osteotomie (TECABO) empfohlen. Eine Evaluierung der Wirksamkeit ein... | de |
pair_33830550 | Some dogs with chronic otitis externa (OE) develop proliferation of the tissues surrounding the opening of the external ear canal, resulting in obstruction. Traditionally total ear canal ablation with bulla osteotomy (TECABO) has been recommended. To evaluate the efficacy of a novel treatment using carbon dioxide (CO<s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Alguns cães com otite externa (OE) crônica desenvolvem proliferação dos tecidos no entorno da abertura do conduto auditivo externo, resultando em obstrução. Tradicionalmente, a ablação total do conduto auditivo com osteotomia de bulha (TECABO) tem sido recomendada. Avaliar a eficácia de um novo tratamento utilizando ci... | pt |
pair_33830550 | Some dogs with chronic otitis externa (OE) develop proliferation of the tissues surrounding the opening of the external ear canal, resulting in obstruction. Traditionally total ear canal ablation with bulla osteotomy (TECABO) has been recommended. To evaluate the efficacy of a novel treatment using carbon dioxide (CO<s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | algunos perros con otitis externa crónica (OE) desarrollan proliferación de los tejidos que rodean la apertura del canal auditivo externo, lo que provoca una obstrucción. Tradicionalmente se ha recomendado la ablación total del canal auditivo con osteotomía de bulla (TECABO). OBJETIVOS: Evaluar la eficacia de un tratam... | es |
pair_33830555 | Elimination diet trials and food challenge tests remain the gold standard for diagnosing cutaneous adverse food reaction (CAFR) in dogs. However, food challenge tests are difficult to perform owing to a lack of definite information on expected clinical signs and the time frame within which they develop after challenge.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 食物排查试验和食物激发试验仍然是诊断犬皮肤不良食物反应(CAFR)的金标准。然而, 在激发试验后, 由于预期临床症状和发作时间信息不明确, 因此难以进行食物激发试验。 目的: 报告进行食物激发试验的私家犬的观察结果。 方法和材料: 对瘙痒犬的病历进行回顾性评价。在入组研究前, 治疗皮肤感染和/或寄生虫。本研究纳入了接受食物排查试验得到临床改善, 并且食物激发试验复发的犬。用瘙痒视觉模拟量表评分,记录食物排查试验前, 以及试验结束时在激发试验前的瘙痒指数。犬主人记录了临床症状复发的时间, 以及食物激发试验后的身体发病部位。 结果: 我们检查了310只瘙痒犬的病历, 其中诊断为CAFR的46只犬纳入组本研究。食物排查试验后观察到... | zh-cn |
pair_33830555 | Elimination diet trials and food challenge tests remain the gold standard for diagnosing cutaneous adverse food reaction (CAFR) in dogs. However, food challenge tests are difficult to perform owing to a lack of definite information on expected clinical signs and the time frame within which they develop after challenge.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Un régime d’éviction et un test de provocation alimentaire restent le gold standard pour le diagnostic des réactions cutanée liées à l’alimentation (CAFR) chez les chiens. Cependant, les tests alimentaires sont difficiles à réaliser compte tenu du manque d’informations précises sur les signes cliniques attendus et le t... | fr |
pair_33830555 | Elimination diet trials and food challenge tests remain the gold standard for diagnosing cutaneous adverse food reaction (CAFR) in dogs. However, food challenge tests are difficult to perform owing to a lack of definite information on expected clinical signs and the time frame within which they develop after challenge.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Eliminationsdiäten und Futterprovokationstests bleiben der Goldene Standard zur Diagnose kutaner Futtermittelnebenwirkungen (CAFR). Futterprovokationstests sind allerdings schwierig durchzuführen, was darin begründet ist, dass ein Mangel an definitiver Information in Bezug auf die zu erwartenden klinischen Zeichen best... | de |
pair_33830555 | Elimination diet trials and food challenge tests remain the gold standard for diagnosing cutaneous adverse food reaction (CAFR) in dogs. However, food challenge tests are difficult to perform owing to a lack of definite information on expected clinical signs and the time frame within which they develop after challenge.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | As dietas de eliminação e o desafio dietético continuam sendo o padrão ouro para o diagnóstico de reações adversas a alimentos (CAFRs) em cães. Entretanto, o desafio dietético é complicado de se realizar devido à falta de informações definitivas sobre os sinais clínicos esperados e em quanto tempo eles se desenvolvem a... | pt |
pair_33830555 | Elimination diet trials and food challenge tests remain the gold standard for diagnosing cutaneous adverse food reaction (CAFR) in dogs. However, food challenge tests are difficult to perform owing to a lack of definite information on expected clinical signs and the time frame within which they develop after challenge.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | las pruebas de dieta de eliminación y las pruebas de provocación alimentaria siguen siendo el modelo estándar para el diagnóstico de reacciones adversas alimentarias cutáneas (CAFR) en perros. Sin embargo, las pruebas de provocación alimentaria son difíciles de realizar debido a la falta de información definitiva sobre... | es |
pair_33830557 | Strain elastography (SE) is a modern imaging technology that provides an additional way of evaluating the changes in soft tissue elasticity caused by pathophysiological processes. Despite its widespread use in human medicine, only a few studies on the application of SE in veterinary medicine are available. To evaluate ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 应变弹性成像(SE)是一种现代成像技术, 为评价病理生理过程引起的软组织弹性成像变化提供了额外的方法。尽管SE在人类医学中得到了广泛的应用, 但在兽医领域研究中SE很少被应用。 目的: 评价在标准超声技术中, SE作为一体化成像模型的潜在实用性, 以更好地区分犬身上的炎性和肿瘤性皮肤结节。 动物: 51只私家犬, 在常规皮肤病学检查期间发现单个或多个皮肤结节的临床症状。 方法和材料: 用超声评估65个皮肤结节的边缘、回声、回声结构、钙化和血管形成, SE用于定性 (E评分、E指数、E2) 和半定量(SR)参数评分。以细胞学和组织学结果作为金标准, 对诊断率进行了比较。 结果: 肥大细胞和良性毛囊肿瘤在肿瘤结节中表现出最高的E... | zh-cn |
pair_33830557 | Strain elastography (SE) is a modern imaging technology that provides an additional way of evaluating the changes in soft tissue elasticity caused by pathophysiological processes. Despite its widespread use in human medicine, only a few studies on the application of SE in veterinary medicine are available. To evaluate ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’élastographie (SE) est une technologie d’imagerie moderne qui fournit un moyen additionnel d’évaluation des changements d’élasticité des tissus mous causé par des processus patho-physiologiques. Malgré son utilisation étendue en médecine humaine, peu d’études sont disponibles sur l’application de SE en médecine vétér... | fr |
pair_33830557 | Strain elastography (SE) is a modern imaging technology that provides an additional way of evaluating the changes in soft tissue elasticity caused by pathophysiological processes. Despite its widespread use in human medicine, only a few studies on the application of SE in veterinary medicine are available. To evaluate ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Strain Elastografie (SE) ist eine moderne bildgebende Technologie, die eine zusätzliche Methode zur Evaluierung von Veränderungen der Weichteilelastizität, die durch pathophysiologische Prozesse entsteht, darstellt. Trotz der weitverbreiteten Verwendung in der Humanmedizin gibt es nur wenige Studien über die Anwend... | de |
pair_33830557 | Strain elastography (SE) is a modern imaging technology that provides an additional way of evaluating the changes in soft tissue elasticity caused by pathophysiological processes. Despite its widespread use in human medicine, only a few studies on the application of SE in veterinary medicine are available. To evaluate ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A elastografia de tensão (ET) é uma tecnologia de imagem moderna que proporciona um modo adicional de avaliar as alterações na elasticidade de tecidos moles causados por processos patofisiológicos. Apesar da sua ampla utilização na medicina humana, poucos estudos sobre a aplicação da ET na medicina veterinária estão di... | pt |
pair_33830557 | Strain elastography (SE) is a modern imaging technology that provides an additional way of evaluating the changes in soft tissue elasticity caused by pathophysiological processes. Despite its widespread use in human medicine, only a few studies on the application of SE in veterinary medicine are available. To evaluate ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la elastografía de deformación (SE) es una tecnología de imagen moderna que proporciona una forma adicional de evaluar los cambios en la elasticidad de los tejidos blandos causados por procesos fisiopatológicos. A pesar de su uso generalizado en medicina humana, solo se encuentran disponibles unos pocos estudios sobr... | es |
pair_33830562 | Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin lesions of variable severity in the pastern area. Despite the widespread use of antibacterial therapy for treating this condition, little is known about the contributing bacteria. To investigate the bacterial skin microbiota in EPD-affected a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 马骹皮炎(EPD)是一种多因素综合征, 表现为不同严重程度的骹部皮肤病变。尽管抗菌治疗被广泛用于治疗这种疾病, 但对相关细菌知之甚少。 假设/目的: 研究EPD的发病和未发病 (对照) 骹的细菌皮肤微生物群。 动物: 病例对照研究, 80匹私家马; 每匹马至少有1处骹部发生和未发生EPD。 方法和材料: 马按EPD形式 (轻度、渗出性或增生性) 、指定的严重程度等级和前期治疗类型 (消毒剂、外部抗菌或无抗菌治疗) 分组。留取皮肤拭子, 比较各组菌群组成。 结果: 发病骹的细菌α多样性降低(P<0.001), 这种降低与EPD形式显著相关(P<0.001), 而与治疗类型无关(P>0.14)。β多样性分析证实, 与对照骹相比,... | zh-cn |
pair_33830562 | Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin lesions of variable severity in the pastern area. Despite the widespread use of antibacterial therapy for treating this condition, little is known about the contributing bacteria. To investigate the bacterial skin microbiota in EPD-affected a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La dermatite des paturons équine (EPD) est un syndrome multifactoriel qui se manifeste par des lésions cutanées de sévérité variable du paturon. Malgré l’utilisation répandue d’antibiotiques pour le traitement, on en sait peu sur le rôle des bactéries. HYPOTHÈSES/OBJECTIFS: Etudier le microbiote bactérien cutané des pa... | fr |
pair_33830562 | Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin lesions of variable severity in the pastern area. Despite the widespread use of antibacterial therapy for treating this condition, little is known about the contributing bacteria. To investigate the bacterial skin microbiota in EPD-affected a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die equine Pastern Dermatitis (Mauke), ein multifaktorielles Syndrom, manifestiert sich in Form von Hautveränderungen von unterschiedlichem Ausmaß in der Fesselbeuge. Trotz der weitverbreiteten Verwendung antibakterieller Therapie zur Behandlung dieses Zustandes, ist wenig bekannt über die beteiligten Bakterien. Eine U... | de |
pair_33830562 | Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin lesions of variable severity in the pastern area. Despite the widespread use of antibacterial therapy for treating this condition, little is known about the contributing bacteria. To investigate the bacterial skin microbiota in EPD-affected a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A dermatite de quartela equina (DQE), uma síndrome multifatorial, manifesta-se como lesões cutâneas de gravidade variável na região da quartela. Apesar do amplo uso de antibioticoterapia para o tratamento desta condição, pouco se sabe sobre as bactérias que contribuem. HIPÓTESE/OBJETIVOS: Investigar a microbiota bacter... | pt |
pair_33830562 | Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin lesions of variable severity in the pastern area. Despite the widespread use of antibacterial therapy for treating this condition, little is known about the contributing bacteria. To investigate the bacterial skin microbiota in EPD-affected a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la dermatitis de la cuartilla equina (EPD), un síndrome multifactorial, se manifiesta como lesiones cutáneas de gravedad variable en el área de la cuartilla. A pesar del uso generalizado de la terapia antibacteriana para tratar esta afección, se sabe poco acerca de las bacterias contribuyentes. HIPÓTESIS/OBJETIVOS: Inv... | es |
pair_33830571 | Interleukin (IL)-31 is a cytokine involved in allergic inflammation which induces pruritus across species including dogs. Using recombinant canine IL-31 we have developed a model of pruritus in the dog to evaluate onset of action and duration of effect of therapeutic drugs. To assess the onset of action and duration of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 白细胞介素(IL)-31是一种参与过敏性炎症的细胞因子, 可在包括犬等多物种体内诱导瘙痒。使用重组犬IL-31, 我们开发了犬瘙痒模型, 以评价治疗药物的起效时间和作用持续时间。 目的: 评估洛基维特单抗(赛妥敏)在IL-31诱导瘙痒模型中的起效时间和作用持续时间。 动物: 24只专门饲养的比格犬 (去势雄性、切除卵巢和完整雌性) , 1.5-4.7岁, 体重6-14 kg。 方法: 随机、设盲、安慰剂对照研究旨在评价洛基维特单抗的止痒特性。实验室比格犬经皮下给予安慰剂、0.125、0.5或2.0 mg/kg 洛基维特单抗。然后给予IL-31,以评价安慰剂或洛基维特单抗给药后3-5h以及给药后1、7、14、28、42和56天... | zh-cn |
pair_33830571 | Interleukin (IL)-31 is a cytokine involved in allergic inflammation which induces pruritus across species including dogs. Using recombinant canine IL-31 we have developed a model of pruritus in the dog to evaluate onset of action and duration of effect of therapeutic drugs. To assess the onset of action and duration of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’interleukine (IL)-31 est une cytokine impliquée dans l’inflammation allergique qui induit le prurit pour toutes les espèces dont le chien. En utilisant un IL-31 recombinant nous avons développés un modèle de prurit chez le chien pour évaluer le début de l’action et la durée des effets des traitements. Déterminer le d... | fr |
pair_33830571 | Interleukin (IL)-31 is a cytokine involved in allergic inflammation which induces pruritus across species including dogs. Using recombinant canine IL-31 we have developed a model of pruritus in the dog to evaluate onset of action and duration of effect of therapeutic drugs. To assess the onset of action and duration of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Interleukin (IL)-31 ist ein Zytokin, welches bei der allergischen Entzündung involviert ist und Juckreiz bei allen Spezies wie auch beim Hund auslöst. Wir haben beim Hund ein Juckreiz Modell entwickelt, wobei wir eine rekombinante Form von caninem IL-31 verwendet haben, um den Wirkungseintritt und die Dauer der Wirkung... | de |
pair_33830571 | Interleukin (IL)-31 is a cytokine involved in allergic inflammation which induces pruritus across species including dogs. Using recombinant canine IL-31 we have developed a model of pruritus in the dog to evaluate onset of action and duration of effect of therapeutic drugs. To assess the onset of action and duration of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A interleucina (IL) -31 é uma citocina envolvida na inflamação alérgica que induz prurido em várias espécies, incluindo cães. Utilizando IL-31 canina recombinante, desenvolvemos um modelo de prurido em cães para avaliar o início da ação e a duração do efeito de drogas terapêuticas. Avaliar o início de ação e a duração ... | pt |
pair_33830571 | Interleukin (IL)-31 is a cytokine involved in allergic inflammation which induces pruritus across species including dogs. Using recombinant canine IL-31 we have developed a model of pruritus in the dog to evaluate onset of action and duration of effect of therapeutic drugs. To assess the onset of action and duration of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la interleuquina (IL)-31 es una citoquina involucrada en la inflamación alérgica que induce prurito en todas las especies, incluidos los perros. Utilizando IL-31 canina recombinante, hemos desarrollado un modelo de prurito en el perro para evaluar el inicio de la acción y la duración del efecto de los fármacos terapéut... | es |
pair_33830579 | Long-term follow-up of oral fluralaner for canine demodicosis has not been demonstrated. A multicentre prospective open trial for the efficacy of oral fluralaner for the long-term (>12 month) management of canine demodicosis. Client-owned dogs diagnosed with demodicosis at nine veterinary clinics. A single fluralaner d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 尚无口服氟雷拉纳治疗犬蠕形螨病的长期随访记录。 目的: 一项评价口服氟雷拉纳长期 (> 12个月) 治疗犬蠕形螨病疗效的多中心前瞻性开放试验。 动物: 在9家兽医诊所诊断为蠕形螨病的私家犬。 方法和材料: 氟雷拉纳口服给药一次。虽然允许使用香波治疗继发性脓皮病, 但除治疗可能的潜在疾病的药物外, 不允许使用其他药物或香波。每只犬每月接受一次全面的寄生虫学和皮肤病学评估, 持续3个月, 并随访 > 12个月。 结果: 入组26只犬。其年龄3个月~16岁。这些病例为9例幼年和17例成年发病; 18例全身型和8例局部型。氟雷拉纳给药可100%根除螨虫, 3个月时所有皮肤病变完全消退。17只犬从1年随访评价中排除, 因为其需要第二次... | zh-cn |
pair_33830579 | Long-term follow-up of oral fluralaner for canine demodicosis has not been demonstrated. A multicentre prospective open trial for the efficacy of oral fluralaner for the long-term (>12 month) management of canine demodicosis. Client-owned dogs diagnosed with demodicosis at nine veterinary clinics. A single fluralaner d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Le suivi au long cours de flurolaner oral pour la démodécie canine n’a pas été réalisé. Une étude ouverte multicentrique prospective pour l’efficacité du flurolaner oral au long cours (>12 mois) dans la gestion de la démodécie canine. Des chiens de propriétaires diagnostiquées avec démodécie dans neufs cliniques vétéri... | fr |
pair_33830579 | Long-term follow-up of oral fluralaner for canine demodicosis has not been demonstrated. A multicentre prospective open trial for the efficacy of oral fluralaner for the long-term (>12 month) management of canine demodicosis. Client-owned dogs diagnosed with demodicosis at nine veterinary clinics. A single fluralaner d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Bisher wurde kein langfristiger Follow-Up einer Demodikose Behandlung mit Fluralaner demonstriert. Eine Multicenter prospektive offene Studie zur Wirksamkeit von Fluralaner per os zur Langzeitbehandlung (>12 Monate) der caninen Demodikose. Es wurden Hunde in Privatbesitz, die in neun veterinärmedizinischen Kliniken mit... | de |
pair_33830579 | Long-term follow-up of oral fluralaner for canine demodicosis has not been demonstrated. A multicentre prospective open trial for the efficacy of oral fluralaner for the long-term (>12 month) management of canine demodicosis. Client-owned dogs diagnosed with demodicosis at nine veterinary clinics. A single fluralaner d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Não foi ainda demonstrado o acompanhamento de longo prazo do uso de fluralaner por via oral para cães com demodiciose. Um ensaio clínico prospectivo multicêntrico para avaliar a eficácia do fluralaner oral no manejo de demodiciose canina em longo prazo (> 12 meses). Cães de proprietários diagnosticados com demodiciose ... | pt |
pair_33830579 | Long-term follow-up of oral fluralaner for canine demodicosis has not been demonstrated. A multicentre prospective open trial for the efficacy of oral fluralaner for the long-term (>12 month) management of canine demodicosis. Client-owned dogs diagnosed with demodicosis at nine veterinary clinics. A single fluralaner d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | no se ha investigado el seguimiento a largo plazo de fluralaner oral para la demodicosis canina. OBJETIVOS: Un estudio abierto, prospectivo, multicéntrico de la eficacia del fluralaner oral para el tratamiento a largo plazo (>12 meses) de la demodicosis canina. ANIMALES: perros de propietarios privados diagnosticados c... | es |
pair_33832030 | Endodontic diseases, due to the high incidence rate, affect the life quality and aesthetics of patients. As an auxiliary examination method, oral radiographic examination is of great significance for the preoperative diagnosis, treatment and postoperative evaluation of endodontic diseases. The principle of choosing ora... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 牙体牙髓疾病发病率高，影响患者的生活质量和美观。口腔放射学检查作为一种辅助检查手段，对于牙体牙髓疾病的术前诊断、治疗以及术后评估都至关重要。选择口腔放射学检查的原则是为诊疗提供精准必要信息的同时最大限度保障患者的利益。中华口腔医学会牙体牙髓病学专业委员会在广泛征求意见、参考相关文献的基础上，经过多次讨论和修订，形成推荐性应用指南。本指南涵盖牙体牙髓病诊疗中常见的放射学临床应用场景，并提供了放射检查方法的推荐意见。希望通过本指南的制定，解决现阶段存在的重要临床问题，为牙体牙髓病诊疗中放射学检查方法的应用提供依据。. | zh-cn |
pair_33832031 | Tooth preparation is the primary and core operation technique for prosthodontics. Microscopic tooth preparation can improve the accuracy and efficiency of the operation. Experts from Society of Prosthodontics, Chinese Stomatological Association formulated the standard operating procedure for microscopic tooth preparati... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 牙体预备手术是口腔修复治疗不可或缺的核心操作，显微牙体预备手术可提高牙体预备的精确性和预备质量。中华口腔医学会口腔修复学专业委员会组织专家，制定显微牙体预备手术操作规范，标准化该技术的设计要点和操作流程，突出其与传统裸眼水平下牙体预备手术的区别，以促进显微牙体预备手术的推广和应用。. | zh-cn |
pair_33832039 | To evaluate the clinical value of emergency endovascular embolization in the interventional treatment for oral hemorrhage caused by carcinoma, 32 patients with oral hemorrhage caused by carcinoma, who received emergency endovascular embolization due to unsatisfactory hemostatic effect of conventional conservative treat... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为分析恶性肿瘤致口腔出血的急诊血管内栓塞介入治疗价值，本研究纳入2014年1月至2019年12月期间郑州大学第一附属医院介入科收治的32例恶性肿瘤致口腔出血患者，均因常规保守治疗止血效果不理想而接受急诊血管内栓塞介入治疗，其中男性和女性各16例，年龄（60.6±13.6）岁（34~88岁）。回顾性分析患者的临床资料、实验室数据与影像学检查，计算急诊血管内栓塞介入治疗恶性肿瘤致口腔出血的技术成功率、即时口腔出血成功控制率、血压、血红蛋白、术后并发症及口腔出血复发率。结果显示，患者急诊血管内栓塞技术成功率及即时口腔出血控制成功率均为100%（32/32）；13%（4/32）患者复发口腔出血。术后所有患者的失血性休克症状均较术前显著改善。... | zh-cn |
pair_33832043 | Chronic periodontitis is a disease of periodontal supporting tissue infection caused by various causes. It was believed that the oral bacteria were the initiator of chronic periodontitis, and the host immune factors would affect the developing process and outcome of periodontitis, although the specific regulatory mecha... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 慢性牙周炎是由多种致病因素引起的牙周组织慢性炎症。目前认为，细菌是慢性牙周炎的始动因子，宿主免疫影响牙周炎的发展和结局，其调控机制尚未完全清楚。细胞外囊泡是一类细胞旁分泌产生的亚细胞成分，可携带多种遗传信息介导细胞通信。细胞外囊泡已在肿瘤、心脑血管及免疫性疾病的诊疗中取得重要研究成果，为一些难治性疾病的早期诊断、对因治疗、疫苗设计提供了研究途径。在牙周组织中，牙周膜干细胞、牙龈间充质干细胞、骨髓间充质干细胞、成骨细胞、破骨细胞、免疫细胞及牙周致病菌均可释放不同成分的细胞外囊泡，进行细胞通信和调控，影响慢性牙周炎的疾病进程。本文介绍了牙周组织及牙周致病菌来源的细胞外囊泡特点，综述了细胞外囊泡参与调控慢性牙周炎的研究进展，并展望了细胞外... | zh-cn |
pair_33832044 | Guided bone regeneration technique is a conventional method to repair various bone defects among series of techniques for bone augmentation around implant. Due to the excellent mechanical properties and biological compatibility, titanium mesh has unique advantages in the application of guided bone regeneration technolo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 引导骨再生是修复各类种植体周围骨缺损的常规治疗手段。钛网因其物理特性及生物相容性方面的特点，在引导骨再生领域具备临床适用范围广、成骨效果稳定等独特优势。目前，临床应用钛网仍可出现一定的并发症，但已有多项预防此类问题的研究报道。本文综述钛网的特点、临床应用、常见并发症及其应用改良的研究进展，以期为钛网的基础研究和临床应用提供参考。. | zh-cn |
pair_33832046 | Myopia has emerged as a public health problem with its increasing prevalence in children and adolescents in China. The Chinese government has begun to take action to address this issue in recent years. In 2018, the Implementation Plan of the Myopia Prevention and Control for Children and Adolescents was issued by the M... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年我国儿童青少年近视眼的患病率逐年增加，已成为我国重大公共卫生问题，引起国家高度关注。2018年，国家教育部、国家卫生健康委员会等8个部委联合印发《综合防控儿童青少年近视实施方案》，把近视眼防控提升到国家战略层面。本文针对我国儿童青少年近视眼防控的现状和特点，剖析现阶段相关工作的重点和难点，以期为我国近视眼防控提供科学思路和参考。<i>（中华眼科杂志，2021，57：241-244）</i>. | zh-cn |
pair_33832047 | Adolescent myopia has become one of the researchers' focuses among visual problems around the world. Carrying out a scientific and efficient epidemiological study on myopia is an essential basis for discovering the rules of the occurrence and the development of myopia, exploring related influencing factors and identify... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 儿童青少年近视眼已成为当今世界视觉问题焦点之一。开展科学并高效的近视眼流行病学调查是发现近视眼发生发展规律、探索相关影响因素、研究问题机制的重要基础，且对近视眼早发现早控制的策略制定至关重要。纵观国内外近视眼流行病学调查，经历了漫长的探索性尝试和逐步规范统一的过程，新技术和新发现亦不断促使近视眼流行病学调查工作的进步。本文针对20世纪至今的社会发展情况及青少年近视眼现患率特征，将近视眼流行病学调查研究归纳为4个阶段，并针对4个阶段的相关研究及结果展开述评，基于不同年代近视眼流行病学调查研究方法和策略、发展和革新，提出现阶段青少年近视眼流行病学调查的重要切入点和研究要素<i>。（中华眼科杂志，2021，57：245-250）</i>. | zh-cn |
pair_33832048 | The concept of diagnosis and treatment of keratoconus is constantly updated. Today, we are not only concerned with how to delay the progress of the disease, but also with the preservation of useful vision for patients as well as improvement of visual quality. With the precise and individualized application of excimer l... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 如今圆锥角膜的诊疗理念不断更新，人们不仅关注于如何延缓圆锥角膜进展，也在努力提高患者的视觉质量。随着准分子激光和飞秒激光技术在眼科的应用，角膜胶原交联术联合不规则角膜准分子激光切削术的治疗方案已成为圆锥角膜治疗的新策略。然而已逐渐变薄的圆锥角膜患眼是否可再进一步行准分子激光切削、该方案两种手术同期和分期执行孰优孰劣等关键问题尚无定论，本文基于这两个关键问题展开论述，以期为临床合理选择最优化的解决方案提供指导。<i>（中华眼科杂志，2021，57：251-253）</i>. | zh-cn |
pair_33832049 | Eye burns, which are usually caused by chemicals such as acidic, alkaline and heat-related substances, are true medical emergencies. These substances can lead to potential permanent damage to the eyelids, cornea, ocular surface and intraocular tissues. In severe cases, eye burns may result in blindness. Currently, ther... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 眼烧伤主要包括化学烧伤和热烧伤，通常由酸性、碱性等化学物质或热源物质等接触角膜、眼表、眼睑以及周围皮肤等造成，是临床常见的眼科急症。烧伤物质可对眼睑、眼表、角膜及眼内组织造成潜在的永久性损伤，甚至导致失明。目前临床对于眼烧伤缺乏规范统一的诊疗方法和标准，导致相当一部分患者预后不良。为此中华医学会眼科学分会角膜病学组经过充分讨论，制定本共识，以期为眼烧伤的临床诊疗工作提供指导性意见。<i>（中华眼科杂志，2021，57：254-260）</i>. | zh-cn |
pair_33832055 | Atropine is a classical drug with a wide use in clinical practice. In ophthalmology, atropine can be used for cycloplegia before optometry, and the treatment of amblyopia, iridocyclitis, malignant glaucoma, etc. In recent years, the 'old drugs with new application ' research and application of atropine for myopia preve... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 阿托品是一种在临床上应用甚广的经典药物，在眼科方面，阿托品可用于验光前的散瞳以及治疗弱视、虹膜睫状体炎、恶性青光眼等。近年来，阿托品用于近视眼防控这一“老药新用”的现象成为热点，其有效性已得到初步认可，但在广泛推广应用于临床前，阿托品的安全性同样应受到关注。本文回顾了有关阿托品用于近视眼防控的不良反应情况，因瞳孔扩大引起的畏光最为常见，其次是视物模糊、过敏及炎症反应、局部刺激症状，其他报道的不良反应还有停药反弹、干眼、眼压升高、全身反应、光损伤及毒性作用等。其中，一些不良反应仅为理论推测，还有一些长期效应未明确，待进一步研究探索。目前，阿托品防控近视眼作为临床研究性探索应用是有益的，但应重视其安全性与疗效的评估。<i>（中华眼科杂志... | zh-cn |
pair_33832056 | Coronaviruses are a common class of respiratory viruses that can cause human infections. 2019 novel coronavirus(2019-nCoV), a new coronavirus that has recently caused a pandemic, has affected millions of people and put tremendous pressure on the health systems of almost every country in the world. Coronaviruses are kno... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 冠状病毒是可感染人类的一类常见呼吸道病毒，已知其是通过飞沫和密切接触在人与人之间传播。近期在世界范围内流行的2019新型冠状病毒（2019-nCoV）已造成数以千万人感染，在部分临床确诊患者的结膜分泌物和泪液中发现了2019-nCoV。本文就冠状病毒在眼表传染的解剖基础、其受体在眼部的表达特征、临床前动物研究结果以及患者临床表现，对文献进行总结和分析，以探讨眼部作为传播途径的可能性，同时提出眼部防护的思考和建议，以供眼科医师在临床工作中参考。<i>（中华眼科杂志，2021，57：305-310）</i>. | zh-cn |
pair_33834665 | Oromaxillofacial hard tissue defects is still a difficult problem in clinical treatment. Regeneration of oromaxillofacial hard tissue based on tissue engineering technology has a good clinical application prospect. The functional modification of scaffolds is one of key factors that influence the outcome of tissue regen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肿瘤术后、外伤、牙周病、先天畸形等因素造成的口腔颌面部骨和牙等硬组织的缺损与缺失严重影响人的身心健康。如何有效保存和功能性修复口腔颌面部骨和牙等硬组织一直是临床治疗的重点和难题。基于组织工程技术的颌面部硬组织的再生治疗具有良好的临床应用前景。通过模拟生物的天然结构及成分对生物材料及干细胞投递方式进行仿生设计的策略，因其简洁、高效的优势逐渐成为研究热点。本文对目前仿生策略用于口腔颌面部骨再生与牙种植的研究进行综述，以期为口腔颌面部硬组织缺损和缺失的治疗提供新思路。. | zh-cn |
pair_33834666 | Oral-maxillofacial hard tissue is the support of maxillofacial structure and appearance, and lays the foundation for functions of oral and maxillofacial system. Once the defect occurs, it will not only affect the physiological functions such as chewing and pronunciation, but also have a significant impact on the psycho... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 口腔颌面部硬组织是颌面部外形结构的支撑和口颌系统功能的基础，一旦发生缺损，不仅影响患者的咀嚼、发音等生理功能，还会对患者的心理及社交造成重大影响。而口腔颌面部硬组织的自我修复能力有限，缺损修复离不开人工材料，但人工材料的理化性能及结构特性与人体硬组织差距巨大，导致修复效果不佳。基于此，学者们通过模拟硬组织发育中的生物矿化过程，即仿生矿化技术，来提高材料的结构及功能的仿生性，实现增强修复效果的目的。目前对生物矿化理论的认识及仿生修复体系的构建处在快速发展阶段，新的研究不断涌现。本文将从几个方面对近年来仿生修复技术在口腔颌面部硬组织修复应用中取得的进展进行综述。. | zh-cn |
pair_33834678 | Photodynamic therapy (PDT) has developed rapidly in basic and clinical research, and its therapeutic prospects have received increasing attention. PDT has the advantages of minimally invasive, low toxicity, high selectivity, good reproducibility, protection of appearance and vital organ function, and has become a treat... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 光动力疗法（PDT）在基础理论和临床应用研究领域发展迅速，其表现出的治疗前景越来越受到广泛的重视。PDT具有微创、低毒副作用、高选择性、重复性好、可保护容貌及重要器官功能等优点，已经成为一种新的治疗手段。随着医学的发展，PDF的适用领域越来越广泛，为口腔疾病的治疗带来了新的研究方向。本文对PDT的基本原理、治疗要素及在口腔疾病治疗中应用的研究成果进行综述。. | zh-cn |
pair_33834679 | Bone invasion by oral cancer is a common clinical problem, which affects the choice of treatment and predicts a poor prognosis. Unfortunately, the molecular mechanism of this phenomenon has not been fully elucidated. Current studies have revealed that oral cancer cells modulate the formation and function of osteoclasts... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 口腔癌易于发生颌骨侵犯，影响患者预后，而这一现象的分子机制尚未完全阐明。目前研究发现，口腔癌细胞通过一系列信号分子的表达直接或者间接影响破骨细胞的形成和功能，有多条信号通路参与其调控，其中核因子κB受体活化因子配体/核因子κB受体活化因子/骨保护素信号通路的调节备受关注。本文就口腔癌颌骨侵犯的分子机制研究进展进行综述。. | zh-cn |
pair_33834680 | Secretory carcinoma, a low-grade malignant tumor, occurs mainly in parotid, submandibular gland, and small salivary glands in the mouth. It has not yet been reported in the mandible. Now we report a case occurred in the right mandibular angle of secretory carcinoma, accompanying with its diagnosis, treatment and progno... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 分泌性癌属于低度恶性肿瘤，主要发生于腮腺、下颌下腺或口腔内小唾液腺，发生于颌骨者目前尚未见报道。本文报道1例发生于右侧下颌角的分泌性癌，并结合文献对其诊断、治疗及预后进行讨论。. | zh-cn |
pair_33834681 | Basal cell nevus syndrome (BCNS), also known as Gorlin-Goltz syndrome, is a rare autosomal dominant genetic disease. It is thought to be caused by a mutation in the PTCH1 gene, and its incidence is 1/57 000 to 1/256 000. The case of a 7-year-old patient with BCNS and Duchenne muscular dystrophy was reported in this pap... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 基底细胞痣综合征也称Gorlin-Goltz综合征，是一种罕见的常染色体显性遗传病。目前认为基底细胞痣综合征是PTCH1基因突变所致，发病率为1/256 000~1/57 000。本文报道1例7岁基底细胞痣综合征伴杜氏肌营养不良症患者。. | zh-cn |
pair_33834682 | When design an implant restoration for edentulous patients, many doctors ignore the sufficiency of the interarch distance (vertical distance) or horizontal distance of the patient to accommodate the superstructure and restoration before designing the implant plan. However, the connotation of measuring the interarch dis... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 无牙颌患者选择种植修复方案时，不少医生忽视了应该在建 后研判患者的颌间距离（垂直距离）或水平距离是否足够容纳种植上部结构及修复体等，再进行种植方案设计。而临床上常用的颌间距离（垂直距离）、水平距离的实测内涵和方法还有待明确，常用的术后目测估计除不准确外还易导致种植修复决策路径倒置，导致不少病例植入成功后出现了无法合理修复的尴尬，这种“想到没做到”的主要原因是缺乏关键参数的规范路径和实用工具及方法。本文推荐先建立新的或天然牙、旧义齿保留的正确颌位关系，然后采用更容易把握的目标修复空间的高度和水平距离或夹角作为实测指标，植入术前在 架或口内用实测工具采集各植入位点的骨面或龈面到拟定咬合平面的最小垂直距离（包括龈面高度和骨面高度）和水平距... | zh-cn |
pair_33834683 | Cheilitis is a general term for various types of inflammatory diseases that occur on the lips. The etiology differs and the clinical manifestations and pathological features overlap, leading to difficulties in clinical diagnosis. Reasonable classification is conducive to the diagnosis of cheilitis. However, its classif... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 唇炎是发生在唇部类型各异的炎症疾病的总称，其病因各异，临床表现和病理特点存在重叠，导致了临床诊断的困难。合理的分类有利于唇炎的诊断，但鉴于唇炎自身的特点，其分类存在困难。目前已有学者提出2种不同的分类方案，但尚未建立统一的分类标准。笔者在结合临床实践经验并总结既往唇炎诊疗文献与特殊病案报道的基础上，将从唇炎的病因、临床表现、病理特点及其与全身疾病和特殊疾病的关系出发，对唇炎的分类、临床诊断思路提出建议，以期对复杂的唇炎临床诊治提供一定的参考。. | zh-cn |
pair_33836096 | Infants who experience sensitive caregiving are at lower risk for numerous adverse outcomes. This is especially true for infants born preterm, leading them to be more susceptible to risks associated with poorer quality caregiving. Some research suggests that preterm and full-term infants differ on temperament, which ma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 经过敏感护理的婴儿发生许多不良后果的风险较低。这对于早产儿来说尤其如此, 因为早产会导致他们更易受到护理质量较差的风险的影响。一些研究表明, 早产儿和足月儿在气质上存在差异, 这可能是这些发现的原因之一。本研究旨在探讨早产儿 (M = 30.2周) 和足月儿的婴儿气质 (消极情绪, 积极情感或外向性, 定向或调节能力) 与母亲敏感性的关系。我们假设, 早产婴儿的母亲和困难型气质婴儿的母亲会表现出较低的敏感性, 其表现为对非痛苦的反应性较低, 较低的积极关注性和较高的侵扰性。对18个早产儿和44个足月儿在9个月 (矫正) 大时进行了游戏互动录像和气质测量 (婴儿行为问卷) 。结果表明, 早产儿和足月儿的母亲对婴儿的反应存在显著差异, ... | zh-cn |
pair_33836096 | Infants who experience sensitive caregiving are at lower risk for numerous adverse outcomes. This is especially true for infants born preterm, leading them to be more susceptible to risks associated with poorer quality caregiving. Some research suggests that preterm and full-term infants differ on temperament, which ma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les nourrissons qui font l'expérience de soins sensibles sont à moindre risque pour bien des résultats adverses. Cela est particulièrement vrai des nourrissons nés prématurés, ce qui les amène à être plus susceptibles aux risques liés à une plus mauvaise qualité de soins de la personne qui prend soin d'eux. Certaines r... | fr |
pair_33836096 | Infants who experience sensitive caregiving are at lower risk for numerous adverse outcomes. This is especially true for infants born preterm, leading them to be more susceptible to risks associated with poorer quality caregiving. Some research suggests that preterm and full-term infants differ on temperament, which ma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Der Zusammenhang zwischen kleinkindlichem Temperament und mütterlicher Sensibilität bei Frühgeburten und termingerecht geborenen Kindern Säuglinge, die eine sensible Pflege erfahren, haben ein geringeres Risiko für zahlreiche nachteilige Entwicklungsoutcomes. Dies gilt insbesondere für Frühgeborene, was dazu führt, das... | de |
pair_33836096 | Infants who experience sensitive caregiving are at lower risk for numerous adverse outcomes. This is especially true for infants born preterm, leading them to be more susceptible to risks associated with poorer quality caregiving. Some research suggests that preterm and full-term infants differ on temperament, which ma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los infantes que experimentan un cuidado sensible se encuentran bajo un riesgo más bajo en cuanto a numerosos resultados adversos. Esto es especialmente cierto para infantes nacidos prematuramente, lo cual conlleva que ellos sean más susceptibles a los riesgos asociados con una más pobre calidad de cuidado. Alguna inve... | es |
pair_33843073 | A pilot randomized controlled trial (RCT) was conducted in El Salvador of an intervention ('Thula Sana') previously shown to enhance maternal sensitivity and infant security of attachment in a South African sample. In El Salvador, trained community workers delivered the intervention from late pregnancy to 6 months post... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在萨尔瓦多进行了一项试验性的随机对照试验, 对先前在南非样本中开展的一种干预措施 (“Thula Sana”) 进行了研究, 以提高孕产妇依恋的敏感性和婴儿依恋的安全性。在萨尔瓦多, 作为家访计划的一部分, 经过培训的社区工作人员, 对孕产妇从妊娠晚期到产后六个月开展了干预措施。样本包括64名怀孕的青少年妇女, 年龄在14至19岁之间, 主要生活在农村地区。他们被随机分配为接受干预组或常规护理组。试验开始时收集了人口统计信息, 并在干预后立即对育儿敏感性和婴儿情绪调节进行盲测。研究发现, 这项干预措施对孕产妇的敏感性有很大的积极影响。此外, 与对照组相比, 干预组的婴儿表现出更为规范的行为:在社交挑战任务中, 他们表现出更多恢复沟通... | zh-cn |
pair_33843073 | A pilot randomized controlled trial (RCT) was conducted in El Salvador of an intervention ('Thula Sana') previously shown to enhance maternal sensitivity and infant security of attachment in a South African sample. In El Salvador, trained community workers delivered the intervention from late pregnancy to 6 months post... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | The Impact of a Mother-Infant Intervention on Parenting and Infant Response to Challenge: a pilot randomized controlled trial with Adolescent Mothers in El Salvador Un essai randomisé contrôlé pilote a été fait au Salvador, d'une intervention (‘Thuna Sana’) dont on avait précédemment démontré dans un échantillon Sud-Af... | fr |
pair_33843073 | A pilot randomized controlled trial (RCT) was conducted in El Salvador of an intervention ('Thula Sana') previously shown to enhance maternal sensitivity and infant security of attachment in a South African sample. In El Salvador, trained community workers delivered the intervention from late pregnancy to 6 months post... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Der Einfluss einer Mutter-Kind-Intervention auf Elternkompetenzen und die kindliche Reaktion auf Herausforderung: Eine randomisierte kontrollierte Pilotstudie mit jugendlichen Müttern in El Salvador In El Salvador wurde eine randomisierte kontrollierte Pilotstudie mit einer Intervention („Thula Sana“) durchgeführt, bei... | de |
pair_33843073 | A pilot randomized controlled trial (RCT) was conducted in El Salvador of an intervention ('Thula Sana') previously shown to enhance maternal sensitivity and infant security of attachment in a South African sample. In El Salvador, trained community workers delivered the intervention from late pregnancy to 6 months post... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Un ensayo piloto controlado al azar se llevó a cabo en El Salvador sobre una intervención (‘Thula Sana’) que previamente había mostrado en un grupo muestra sudafricano el mejoramiento de la sensibilidad materna y la seguridad de la afectividad del infante. En El Salvador, trabajadores entrenados de la comunidad llevaro... | es |
pair_28728251 | The etiology and pathogenesis of sleep obstructive apnea hypopnea syndrome (OSAHS) is not yet definitive, evidence shows that the dysfunction of pharyngeal nerve and the atonia of the muscle innervated by these nerve could play an important role in the progress of OSAHS. Dopamine is a neurotransmitter in the central ne... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 阻塞性睡眠暂停低通气综合征(OSAHS)的发病机制仍未完全明确，有证据表明咽部肌肉和神经的功能下降可能在OSAHS发生过程中起重要作用，而舌下神经核直接控制着对主要咽部肌肉——颏舌肌的神经输出量。多巴胺是在睡眠调节中发挥重要作用的神经递质。目前大量证据表明多巴胺对舌下神经核存在潜在的调控作用。本文就多巴胺在睡眠呼吸障碍研究进展方面做一综述。. | zh-cn |
pair_28728280 | The core goal of 'Thirteenth Five-Year Plan for National Eye Health (2016 to 2020)' is to obtain eye health. At present, there are still several problems hampering Chinese eye health management system development, including the lack of top policy design, system protection and financial investment, weak support from pri... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 我国《'十三五'全国眼健康规划（2016—2020年）》的核心工作目标是'眼健康'。目前，我国眼健康管理工作中存在着缺乏顶层设计和制度保障，财政投入不足；基层医疗机构、兄弟学科、社会力量在眼健康管理中的作用较为薄弱；眼健康管理信息化程度相对较低等问题。要使眼健康管理工作行之有效，必须针对性解决眼健康管理的可持续性、眼健康信息的完整性和眼健康支付的可行性这3个挑战性问题。建议眼健康相关医务工作者积极行动起来，努力加强眼病防治工作网络的信息化建设和服务能力建设，广泛开展眼健康促进工作，并切实进行人群眼健康管理模式的研究和实践。（中华眼科杂志，<i>2017</i>，<i>53</i>：<i>481</i>-<i>483</i>）. | zh-cn |
pair_28728290 | Divergence insufficiency is acquired esotropia at distance fixation with symptomatic uncrossed diplopia but fusion at near. It can be divided into two forms: primary isolated form and secondary form associated with neurologic abnormalities, also called divergence palsy. The clinical features of divergence insufficiency... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 分开不足是指后天发生的获得性视远内斜视伴有同侧复视、而视近为双眼单视的一类眼部疾患。可为孤立原发性，即没有神经系统原发疾病的良性病变；亦可为伴随神经系统障碍的继发性分开不足，临床上也称分开麻痹。分开不足临床特征是视远内斜视度数一般较小，无侧方非共同性，视近为正位或小度数内隐斜视，分开性融合幅度降低，眼球外转运动无受限，水平扫视运动速度正常。良性分开不足多发生于50岁以上成年人，近年研究认为高龄患者是因眶内软组织变性致肌肉移位，为机械源性，称为年龄相关性视远内斜视或松弛眼综合征，为与展神经麻痹、潜在神经系统障碍所致的分开不足的鉴别诊断提供了依据。分开不足的治疗以消除复视为目的，采用三棱镜矫正法或手术治疗。文献报道常规内直肌减弱、外直肌... | zh-cn |
pair_28728306 | To establish the standardization of clinical verification designs for in vitro diagnostic devices(IVDs) of human papillomavirus, China Food and Drug Administration (CFDA) and United States Food and Drug Administration (FDA) issued guidelines of detailed study designs and effectiveness evaluation for accuracy validation... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为促进人乳头瘤病毒(HPV)检测试剂盒临床功能验证设计的规范化，中国国家食品药品监督管理总局(CFDA)和美国国家食品药品监督管理总局(FDA)分别针对HPV检测试剂盒核酸检测的准确性验证和临床功能，包括不明意义非典型鳞状细胞(ASC－US)人群分流、联合筛查和初筛的有效性验证方面，从临床试验设计或评价等方面推荐了较为详细的指导原则。中美两国指导原则在研究设计、研究对象、样本量估计和统计分析等关键点的要求略有差异，但评价指标类似。按照CFDA指导原则要求，可采用横断面研究设计代替FDA建议的前瞻性设计进行ASC－US人群分流用途的验证；同时采用前瞻性研究设计，对同一个自然人群进行拟申报产品HPV和细胞学平行检测，通过至少3年细胞学随... | zh-cn |
pair_28738453 | WHO has developed and issued global hepatitis B elimination program. Continuing hepatitis B immunization and conducting community based antiviral treatment for chronic hepatitis B are the most important strategies for hepatitis B elimination. According to the estimation of related cost by WHO, the cost of antiviral the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | WHO制定和发布了全球消除乙型肝炎（乙肝）规划，并在各国推广实施。继续开展乙肝免疫预防，推行基于社区慢性乙肝抗病毒治疗，是消除乙肝最重要的策略。据WHO消除乙肝所需费用测算，后者将消耗巨量资金。中国乙肝免疫预防成效显著，但人群中慢性乙肝数量庞大，消除乙肝需要大量公共卫生资源，对决策构成挑战。乙肝防治经济学研究可为我国消除乙肝提供决策依据和技术支持，由本期'乙肝防治经济学评价'栏目的论文可见，其方法和技术进展令人振奋。. | zh-cn |
pair_28738478 | In the past decade, based on the 'common disease-common variant' hypothesis, genomewide association studies (GWAS) have been extensively used to dissect the genetic components of complex diseases and quantitative traits. However, the identified disease-associated common variants by GWASs can only explain small part of ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在过去的10年间，基于'常见疾病-常见变异'的假设，全基因组关联研究被广泛应用于疾病和复杂性状的遗传学病因研究中。但是，全基因组关联分析发现的疾病相关常见变异，只能解释疾病小部分的遗传风险，造成'遗传度丢失' 。'常见疾病-低频变异'的假设被提出。随着新一代测序技术的发展，低频变异关联研究陆续开展。本文主要对低频变异关联研究的研究设计以及关联分析方法进行综述。. | zh-cn |
pair_28738479 | This paper reviews the concept of risk of bias, followed by demonstrating why assessment of risk of bias in systematic reviews should be different from that of quality of evidence, methodological quality, reporting quality, precision, and external validity. We also discuss the recent development of tools for risk of bi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 本文回顾了偏倚风险的概念，将系统综述中的偏倚风险评价与证据质量、方法学质量、报告质量、精确性、外部真实性等方面的评价作了对比，然后讨论了偏倚风险评估工具的进展、工具本身存在的不足、以及工具使用的常见问题等，以帮助我国系统综述者更好地理解偏倚风险评估及其工具的使用。. | zh-cn |
pair_28738480 | As a common health problem in modern society, sleep disorder have a high incidence in the elderly population, which seriously affect the quality of life and physical and mental health of the elderly, and can even aggravate to cause diseases. This review summarizes main research findings in the field of sleep disorder d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 睡眠障碍作为现代社会的常见病，在老年人群中发病率较高，严重影响了老年人的生活质量和身心健康，并能加重或诱发疾病。本文回顾了过去20年在老年人睡眠障碍领域的主要研究结果，简述了老年人的睡眠特点、睡眠障碍的流行病学分布现状以及可能的影响因素，并提出可行的预防措施和建议。. | zh-cn |
pair_28738481 | Fine Particulate Matter (PM(2.5)-particles with an aerodynamic diameter ≤2.5 μm) can penetrate deeply into the lung, deposit in the alveoli, and consequently impair lung function. Both short term and long term exposures to PM(2.5) are associated with the incidence of respiratory diseases (e.g. asthma, chronic obstructi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | PM(2.5)是指大气中直径小于或等于2.5 μm的颗粒物，它能渗透进肺部，更多的沉积在肺泡里，最终导致肺功能的受损。不论短期还是长期PM(2.5)的暴露都与呼吸系统疾病相关，包括哮喘、慢性阻塞性肺疾病及肺癌。本文主要从流行病学方向出发，阐述环境空气PM(2.5)的暴露对人体呼吸系统的影响。. | zh-cn |
pair_28738959 | FK506, also named tacrolimus, a new macrolide immunosuppressive agent, has been shown to possess anti-proliferation activities in some cancer cells. The aim of this study was to investigate the effect of FK506 on the cell proliferation and migration of lung cancer cell lines and its mechanism. A549 and H1299 cell lines... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 FK506（他克莫司，tacrolimus）是一种大环内酯类的新型免疫抑制剂。研究报道FK506对多种肿瘤细胞具有增殖抑制作用。本研究旨在观察FK506对肺癌细胞增殖和迁移的作用，并探讨其可能的机制。方法 体外培养A549和H1299细胞，采用CCK-8法测定FK506对A549和H1299细胞增殖的作用；EDU标记法检测DNA合成；流式细胞术检测细胞的周期分布情况；Transwell和细胞划痕实验检测细胞的体外迁移能力；Western blot技术检测P27、RB1、CDK4、CDK6和MMP9蛋白的表达。结果 FK506可抑制A549和H1299细胞的增殖、诱导细胞周期G0期/G1期阻滞；与对照组比较，FK506处理... | zh-cn |
pair_28738960 | To explore the function and the potential molecular mechanism of miR-218 in lung cancer cell. The expression of miR-218 mRNA was determined by real-time PCR in lung cancer tissues, adjacent tissues and lung cancer cells. Transwell assay was used to detect the migration and invasion of A549 cell after transfected with A... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 本研究旨在探讨肺癌中miR-218的表达，研究miR-218在肺癌细胞中的功能及其可能的分子机制。方法 应用实时荧光定量 PCR（qRT-PCR）检测15例肺癌组织和15例癌旁组织中miR-218的表达。在肺癌细胞A549中转染miR-218的抑制物（Anti-miR-218），在肺癌细胞HCC4006中转染miR-218的模拟物后，用Transwell实验检测细胞的迁移侵袭能力的变化。用Targetscan和MiRanda软件预测miR-218的可能靶点，转染miR-218的抑制物及模拟物后用qRT-PCR和Western blot检测Robo1的mRNA和蛋白表达水平。用双荧光素酶报告基因方法鉴定miR-218和Ro... | zh-cn |
pair_28738963 | Lung cancer is a serious threat to human health and its morbidity and mortality in recent years has always been ranked first in the country. Lung cancer patients are often associated with anxiety, depression and other emotional problems, and anxiety, depression and other emotional problems will further lead to a series... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 肺癌是一种严重威胁人类健康的恶性肿瘤，其发病率及死亡率近年始终排在全国首位。肺癌患者常伴发焦虑、抑郁等情绪问题，而焦虑抑郁等情绪问题会进一步引发一系列躯体症状。目前，临床上对于肺癌患者的躯体化症状认识不足，相关的临床研究较少，本研究以肿瘤内科患者为研究对象，探究肺癌患者的躯体化症状及其与焦虑、抑郁的相关性分析。方法 对符合躯体化症状诊断标准的肺癌患者，用患者健康问卷躯体症状群量表（Patient Health Questionnaire-15, PHQ-15）中文版进行躯体症状统计，用汉密尔顿焦虑他评量表（Hamilton Anxiety Scale, HAMA）和汉密尔顿抑郁他评量表（Hamilton Depressi... | zh-cn |
pair_28738965 | Surgical resection is the best choice for early lung cancer, but the prognosis of early postoperative lung cancer is still very different, whether or not to apply adjuvant chemotherapy is controversial. This study examines the role of postoperative adjuvant chemotherapy in patients with stage I non-small cell lung canc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 手术是早期肺癌的首选治疗方法，但早期肺癌术后的预后仍有很大差异，术后是否应用辅助化疗也有争议。本研究探讨术后辅助化疗在I期非小细胞肺癌患者中的作用，尤其是在高危人群中的作用。方法 选择北京大学人民医院2009年1月-2013年6月接受手术的Ia期、Ib期肺癌患者，分别以是否行术后化疗分为两组，用Kaplan-Meier法进行生存分析，比较两组术后无瘤生存时间（disease-free survival, DFS）的差异；并按危险因素个数进行评分，分为0分、1分、≥2分三组，比较三组术后DFS的差异；单独比较术后化疗对≥2分的高危组患者的作用。结果 经过筛选后共有465例患者纳入研究，Ia期284例，Ib期181例。Ia期... | zh-cn |
pair_28738964 | Albumin-bound paclitaxel is a novel paclitaxel formulation formed by the combination of paclitaxel and human serum albumin (HSA) to improve the efficacy of paclitaxel and reduce its adverse reactions. The aim of this retrospective study is to observe the efficacy and safety of albumin-bound paclitaxel-based therapy in ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 白蛋白结合型紫杉醇是通过将人血白蛋白与紫杉醇相结合的无需助溶剂的新型紫杉醇制剂，本研究旨在观察白蛋白结合型紫杉醇治疗晚期肺癌的临床疗效及其安全性。方法 选取2011年11月-2014年12月收治的进展期/不可手术的晚期肺癌患者共50例。给予白蛋白结合型紫杉醇130 mg/m2，第1天、第8天单药方案或者联合方案治疗，21 d为1个周期，观察每个周期不良反应，每2个周期按实体瘤疗效评价标准（Response Evaluation Criteria in Solid Tumors, RECIST）1.1进行影像学疗效评价。结果 白蛋白结合型紫杉醇治疗总体客观有效率（overall response rate, ORR）为20... | zh-cn |
pair_28738967 | Lung cancer, of which approximately 85% are non-small cell lung cancer (NSCLC), is one of the most prevalent cancers and the most leading cause of cancer mortality. Despite recent improvements in its treatment, the prognosis remains dismal. Previous studies have clearly proved that estrogen and estrogen receptors (ER) ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肺癌是目前发病率及死亡率最高的恶性肿瘤之一，其中约85%为非小细胞肺癌（non-small cell lung cancer, NSCLC）。尽管其治疗手段不断提高，但总体预后不容乐观。既往研究已证实雌激素系统参与了NSCLC的发生、发展。越来越多的证据表明，抗雌激素治疗不仅可以逆转NSCLC患者对铂类化疗药物的耐药性，还可以增加人类表皮生长因子受体酪氨酸激酶抑制剂的疗效。本文就雌激素系统及抗雌激素治疗在NSCLC中的作用作一综述。. | zh-cn |
pair_28738966 | In the past 20 years, with the popularization of low-dose computed tomography (CT) screening, detection rate of lung nodules increased significantly. However, there are still many difficulties in making qualitative diagnosis for pulmonary nodules. The Lung nodule is a clinical common lung disease. The early onset for m... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近20年来，随着计算机断层扫描（computed tomography, CT）技术的提高和肺癌高危人群筛查的普及，越来越多的肺部小结节被发现，然而肺结节的定性诊断仍有很多困难。肺结节是临床上一种常见的现象，恶性结节早期发病比较隐匿，如果不进行早期干预，其病程迅速、恶性程度强、预后差。如果能在早期阶段对病灶进行手术切除，将会明显改善肺癌患者的预后。目前针对肺结节的处理指南层出不穷，但各大指南均未达成统一的共识。本文拟对在国内影响最大的四个指南：美国国家综合癌症网络非小细胞肺癌（non-small cell lung cancer, NSCLC）临床实践指南、美国胸科医师协会肺癌诊疗指南、Fleischner-Society肺结节处理... | zh-cn |
pair_28162183 | The aim of the study was to explore the effect and its clinical relevance of short-term intensive insulin treatment on plasma concentrations of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and secretory phospholipase A(2) (sPLA(2)) in newly diagnosed type 2 diabetes mellitus (T2DM). Ninety newly diagnosed T2DM... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨短期胰岛素强化治疗对新诊断2型糖尿病(T2DM)患者血浆脂蛋白相关性磷脂酶A(2)(Lp－PLA(2))及分泌型磷脂酶A(2)(sPLA(2))水平的影响及其临床意义。90例新诊断T2DM患者接受胰岛素泵持续皮下输注胰岛素治疗(CSII)2周，治疗后sPLA(2)较治疗前显著降低[173.78(80.95，278.09)μg/L比219.33(130.03，337.30) μg/L ，<i>P</i><0.01]，而Lp－PLA(2)水平降低不显著[88.35(76.74，125.18)μg/L比102.9(76.34，134.31)μg/L，<i>P</i>>0.05]，但二者治疗前后水平的变化与稳态模型评估的胰岛素抵抗(HO... | zh-cn |
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