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pair_31038257 | Otitis is common in alpacas. Suppurative otitis media/interna can be an extension from the external ear canal or from a respiratory infection. Cytological evaluation provides rapid and inexpensive information to assist in therapeutic decision; to date, there is no published information regarding the normal cytological ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Otitis kommt bei Alpacas häufig vor. Eine suppurative Otitis media/interna kann eine Ausdehnung des externen Ohrkanals sein oder von einer respiratorischen Infektion kommen. Die zytologische Evaluierung bringt eine schnelle und billige Information, um einer therapeutischen Entscheidung zu assistieren; bis zum heutigen ... | de |
pair_31038257 | Otitis is common in alpacas. Suppurative otitis media/interna can be an extension from the external ear canal or from a respiratory infection. Cytological evaluation provides rapid and inexpensive information to assist in therapeutic decision; to date, there is no published information regarding the normal cytological ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Otite é comum em alpacas. Otite média/interna supurativa pode ser uma extensão do conduto auditivo externo ou de uma infecção respiratória. A avaliação citológica fornece informações rápidas e de baixo custo para auxiliar na decisão terapêutica; até o momento, não há dados publicados sobre os resultados citológicos e f... | pt |
pair_31038257 | Otitis is common in alpacas. Suppurative otitis media/interna can be an extension from the external ear canal or from a respiratory infection. Cytological evaluation provides rapid and inexpensive information to assist in therapeutic decision; to date, there is no published information regarding the normal cytological ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La otitis es común en las alpacas. La otitis media/interna supurativa puede producirse por una extensión de infección del conducto auditivo externo o de una infección respiratoria. La evaluación citológica proporciona información rápida y económica para ayudar en la decisión terapéutica; Hasta la fecha, no hay informac... | es |
pair_31038261 | Immune-modulating drugs show limited therapeutic efficacy in canine exfoliative cutaneous lupus erythematosus (ECLE); over half of ECLE dogs are eventually euthanized for their lack of response to therapy. To describe a case of generalized ECLE in a dog in which mycophenolate mofetil (MMF) treatment achieved complete r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 免疫调节药物对于犬剥脱性皮肤红斑狼疮(ECLE)的治疗效果有限; 超过一半的ECLE犬最终因治疗无效而被安乐死。 目的: 报告一只全身ECLE患犬,经霉酚酸酯(MMF)治疗后完全缓解的病例。 动物: 一只3岁、去势的雄性德国短毛猎犬,头部、躯干、腹部和四肢内侧,三个月来呈现大片鳞屑、红斑和斑块,毛囊管型和稀毛症。这只犬表现出跛行和步态僵硬。 方法和材料: 全血细胞计数、全项生化、尿液分析、血清抗核抗体试验、组织病理学检查和皮肤活检的RT-qPCR。 结果: 组织学上,皮肤活检样本显示淋巴细胞丰富的界面性皮炎,漏斗部界面性毛囊炎和腺周淋巴细胞浸润。无全身症状和实验室检查无明显异常,排除了并发全身性红斑狼疮的可能性。口服MMF(... | zh-cn |
pair_31038261 | Immune-modulating drugs show limited therapeutic efficacy in canine exfoliative cutaneous lupus erythematosus (ECLE); over half of ECLE dogs are eventually euthanized for their lack of response to therapy. To describe a case of generalized ECLE in a dog in which mycophenolate mofetil (MMF) treatment achieved complete r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les immunomodulateurs montrent une efficacité limitée pour le traitement du lupus cutané érythémateux exfoliatif canin (ECLE); plus de la moitié des chiens atteints de ECLE sont finalement euthanasiés pour leur manque de réponse au traitement. Décrire un cas de ECLE généralisé chez un chien pour lequel le micophénolate... | fr |
pair_31038261 | Immune-modulating drugs show limited therapeutic efficacy in canine exfoliative cutaneous lupus erythematosus (ECLE); over half of ECLE dogs are eventually euthanized for their lack of response to therapy. To describe a case of generalized ECLE in a dog in which mycophenolate mofetil (MMF) treatment achieved complete r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Immunmodulierende Medikamente zeigen eine limitierte therapeutische Wirksamkeit beim exfoliativen kutanen Lupus erythematosus (ECLE) des Hundes; mehr als die Hälfte der ECLE Hunde werden im Endeffekt aufgrund ihrer fehlenden Reaktion auf die Therapie eingeschläfert. Die Beschreibung eines generalisierten ECLE eines Hun... | de |
pair_31038261 | Immune-modulating drugs show limited therapeutic efficacy in canine exfoliative cutaneous lupus erythematosus (ECLE); over half of ECLE dogs are eventually euthanized for their lack of response to therapy. To describe a case of generalized ECLE in a dog in which mycophenolate mofetil (MMF) treatment achieved complete r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Os fármacos imunomoduladores apresentam eficácia terapêutica limitada no lúpus eritematoso cutâneo esfoliativo (ECLE); mais da metade dos cães com ECLE são eventualmente eutanasiados devido a sua pobre resposta terapêutica. Descrever um caso de ECLE generalizado em um cão em que o tratamento com micofenolato de mofetil... | pt |
pair_31038261 | Immune-modulating drugs show limited therapeutic efficacy in canine exfoliative cutaneous lupus erythematosus (ECLE); over half of ECLE dogs are eventually euthanized for their lack of response to therapy. To describe a case of generalized ECLE in a dog in which mycophenolate mofetil (MMF) treatment achieved complete r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | los fármacos inmunomoduladores muestran una eficacia terapéutica limitada en el lupus eritematoso cutáneo exfoliativo canino (ECLE); más de la mitad de los perros con ECLE son finalmente sacrificados por su falta de respuesta al tratamiento. OBJETIVO: describir un caso de ECLE generalizado en un perro en el que el trat... | es |
pair_31038263 | Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in dogs. To evaluate the dose-depen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 向小鼠或人皮肤皮内注射(i.d.)如组胺和化合物48/80这类致痒素,从而引起的抓挠行为,一般是开展瘙痒研究和药物开发的常用模型。这种模型在犬中的预测有效性报道很少。 目的: 评估不同致痒素物质对健康犬的作用机制,及剂量依赖性效果。 动物: 十只健康的比格实验犬。 方法和材料: 所有犬在山羊抗犬IgE(4和25μg/位点)、组胺和复合物48/80(50、100、200、400μg/位点)注射30分钟后(mpi)进行视频记录; 两次缓冲盐水注射作为对照。两名调查者盲法审查了所有视频录像的瘙痒行为,由盲法调查者在30mpi给总体风团评分。 结果: 所有犬在致痒素注射部位均出现风团和红斑; 与对照组相比,各物质在30mpi时的总体... | zh-cn |
pair_31038263 | Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in dogs. To evaluate the dose-depen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les comportements de grattage associés à une injection intradermique (i.d.) de pruritogènes tels que l'histamine et composé 48/80 dans la peau de souris et d'homme est un modèle fréquemment utilisé pour avancer dans la recherche sur le prurit et le développement de traitements. La valeur prédictive de ce modèle est peu... | fr |
pair_31038263 | Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in dogs. To evaluate the dose-depen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Kratzverhalten in Zusammenhang mit einer intradermalen (i.d.) Injektion von Pruritogenen wie Histaminen und Compound 48/80 in die Haut von Mäusen und Menschen ist ein häufig verwendetes Modell, um die Forschung über den Juckreiz und die Entwicklung von Medikamenten voranzubringen. Die prädiktive Validität dieses Modell... | de |
pair_31038263 | Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in dogs. To evaluate the dose-depen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A manifestação de comportamentos de prurido após injeção intradérmica (i.d.) de pruritógenos como a histamina e o composto 48/80 na pele de camundongos e humanos é o modelo comumente utilizado no avanço de pesquisas de prurido e desenvolvimento de fármacos. O valor preditivo deste modelo é pouco documentado em cães. Av... | pt |
pair_31038263 | Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in dogs. To evaluate the dose-depen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | el comportamiento de rascado asociado con la inyección intradérmica (i.d.) de pruritógenos como la histamina y el compuesto 48/80 en la piel de ratones y humanos es un modelo comúnmente utilizado para avanzar en la investigación del picor y el desarrollo de fármacos. La validez predictiva de este modelo está mal docume... | es |
pair_28216491 | To explore the correlation between the -31T/C polymorphisms of IL-1β gene and thesusceptibility of Kawasaki disease (KD).
Methods: The polymorphism at -31C/T site of IL-1β gene was genotyped with the method of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in 100 KD patients (KD group) a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨IL-1β基因启动子区–31T/C位点多态性与川崎病发病的相关性。方法：应用聚合酶链反应-限制性片段长度多态性检测100例川崎病患儿(川崎病组)和100例健康儿童(对照组)的IL-1β –31位点的基因型，并比较两组间基因型及等位基因频率的差异性。结果：IL-1β –31位点基因型分布和等位基因频率在川崎病组与对照组间差异均有统计学意义(均P<0.05)。川崎病组中TT基因型携带者的风险是TT基因非携带者的0.37倍(χ2=5.65，P<0.01，OR=0.37，95%CI：0.16~0.85)，但IL-1β –31位点基因型分布和等位基因频率在川崎病组中合并冠状动脉损伤者与无冠状动脉损伤者之间差异均无统计学意义(均P>0... | zh-cn |
pair_28216493 | To investigate the effect of high frequency electrotherapy (HFE) on rat hippocampus after cerebral ischemia/reperfusion (I/R).
Methods: A rat model of cerebral I/R injury was established. The rats were randomly divided into a sham group, an I/R group and an HFE group. The HFE group received thearapy daily for differen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：观察高频电疗对大鼠脑缺血再灌注损伤后caspase-3和海马神经细胞超微结构的影响。方法： 线栓法制备大鼠一侧大脑中动脉缺血再灌注(middle cerebral artery occlusion and reperfusion，MCAO/R)模型。采用Zea-Longa评分法评定神经功能缺损程度。将符合条件的大鼠随机分成假手术组、模型组及高频电疗组。1，3，7 d后取标本，电镜观察海马神经元细胞超微结构，Western印迹检测caspase-3蛋白的表达。结果：电镜示假手术组海马CA1区神经细胞完整，各细胞器结构、形态正常。模型组海马神经元肿胀、坏死，细胞器碎裂，神经细胞损伤严重。高频电疗后海马神经元损伤均较模型组减轻。同时... | zh-cn |
pair_28216495 | To study the concentration of the asymmetrical dimethyl-L-arginine (ADMA) in patients with pulmonary arterial hypertension (PAH) commbination with congenital heart disease (CHD) and its clinical value as a biomaker for diagnosis and prognosis.
Methods: A total of 100 patients with CHD and 25 healthy adult subjects wer... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：研究血浆不对称二甲基精氨酸(asymmetrical dimethyl-L-arginine，ADMA)作为先天性心脏病(congenital heart disease，CHD)相关肺动脉高压(pulmonary arterial hypertension，PAH)患者诊断、分层与随访指标的应用价值。
方法：收集湘雅二医院心血管内科2013年10月至2014年10月经超声心动图证实的CHD患者(n=100)，将其分为3组：无PAH组、轻中度PAH组、重度PAH组；重度PAH组又分为动力型亚组、艾森曼格综合征前期亚组、艾森曼格综合征亚组；同时收集健康成人作为对照组(n=25)；对20例阻力型患者使用西地那非治疗后随访6个月。采... | zh-cn |
pair_28216498 | To explore whether CT value is useful in identifying different disease in tumors of rhinosinus parenchyma.
Methods: The data of preoperation noncontrast CT in 277 patients were retrospectively reviewed. The final diagnosis and classification were based on the result of surgical histopathological examination. The CT va... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨CT值是否有助于鉴别鼻腔鼻窦软组织肿物的病变性质。方法：回顾性分析277例患者的术前非
增强CT资料，以术后病理结果作为确诊及分类依据。计算各类病变CT值范围并比较各类病变CT值之间的差异。将各类样本重新分析作出诊断，比较将病变CT值范围纳入诊断依据前后的诊断准确率。结果：鼻息肉CT值为(25.3±3.5) Hu，浆液囊肿CT值为(7.9±3.5) Hu，黏液囊肿CT值为(42.2±4.7) Hu，乳头状瘤CT值为(40.7±5.3) Hu，真菌球CT值为(112.3±10.9) Hu，血管瘤CT值为(41.7±4.8) Hu，恶性黑色素瘤CT值为(51.2±9.9) Hu，鳞状细胞癌CT值为(47.1±9.9) Hu。鼻... | zh-cn |
pair_28216499 | To explore the risk factors for nausea and vomiting in pregnant women.
Methods: Using cluster random sampling method and following the exclusion and inclusion criteria, a total of 713 pregnant women from the health service center of 3 street communities in Changsha city district were enrolled. Statistical analysis was... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨妊娠呕吐的相关影响因素。方法：采用整群随机抽样方法，根据排除与纳入标准，收集湖南省长沙市某区3 个街道社区卫生服务中心713例孕妇资料，回顾性收集其孕前、孕期和分娩情况，运用t检验、χ2检验和logistic回归分析孕妇呕吐的相关影响因素。结果：该区妊娠呕吐发生率为59.6%。多因素非条件logistic回归分析结果显示：女胎(OR=1.404，95%CI：1.035~1.905)、有阴道流血经历(OR=1.513，95%CI：1.062~2.156)和负性生活刺激量(OR=1.031，95%CI：1.009~1.054)是妊娠呕吐的危险因素，年龄是妊娠呕吐的保护因素(OR=0.798，95%CI：0.661~0.964)... | zh-cn |
pair_28216500 | To investigate the effect of IL-1β or TNF-α-treated human decidual cells on the balance between Th1 and Th2 or Th17 and Treg.
Methods: Human decidual cells were isolated and treated with estrogen (E2) and progesterone (P) for 7 days and then with IL-1β or TNF-α for 24 h. The culture medium was collected to prepare con... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨IL-1β或TNF-α干预的子宫蜕膜细胞对母胎界面Th1/Th2及Th17/Treg平衡的影响。方法：子宫蜕膜细胞经体外分离后，加入10–8 mol/L雌二醇(E2)+10–7 mol/L孕激素(P)培养7 d后，分别给予IL-1β或TNF-α干预24 h，收集上清液，制备条件培养液。应用条件培养液刺激子宫蜕膜T细胞72 h后，收集上清液，Elisa 法检测上清液IFN-γ，IL-2，IL-17，IL-5，IL-10及TGF-1β的表达。收集子宫蜕膜T细胞，提取RNA，用实时定量PCR检测细胞因子mRNA的表达。通过T细胞分泌的细胞因子水平来评估子宫蜕膜细胞对Th1/Th2及Th17/Treg平衡的影响。结果：IL-1β或... | zh-cn |
pair_28216501 | To determine differences in incidence, causes, clinical manifestation,prognosis between children and adults in patients with Henoch-Schönlein purpura (HSP).
Methods: We retrospectively analyzed clinical data of 337 patients who hospitalized in the Department of Dermatology, Peace Hospital affiliated to Changzhi Medica... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：了解儿童与成人过敏性紫癜(Henoch-Schönlein purpura，HSP)在发病季节、发病诱因、临床表现、实验室检查和预后等方面的异同。方法：回顾性分析长治医学院附属和平医院皮肤性病科2013年2月至2016年1月337例诊断为HSP的住院患者的临床资料，根据年龄分为儿童组(<14岁)和成人组(≥14岁)，分析比较两组的发病率、发病诱因及治愈率。结果：儿童患者195例，成人患者142例，143例年龄≤10岁；儿童秋冬季发病率高于成人(P=0.006)；儿童因上呼吸道感染诱发者多于成人(P<0.01)；年龄≥14岁(P=0.023)、皮肤紫癜复发≥3次(P=0.027)、有消化道症状(P=0.021)、抗链球菌溶血素O... | zh-cn |
pair_28216503 | To evaluate the status of depression and to determine the association between depression and self-efficacy in medical residents.
Methods: Self-made questionnaire of general situation, Patient Health Questionnaire-9, and general self-efficacy scale were applied to 223 new residents from a hospital in Hunan Province to ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：调查参与住院医师规范化培训(住培)医师在高压力环境下的抑郁及自我效能感状况，并探讨抑郁与自我效能感之间的关系。方法：选取湖南某三甲医院新入住培医师223例，采用自制一般情况问卷、患者健康问卷、一般自我效能感量表分别测评住培医师的一般情况、抑郁、自我效能感水平；采用Pearson相关分析和多元逐步回归分析探究住培医师抑郁与自我效能的关系及抑郁相关影响因素。结果：被调查的住培医师无抑郁症状68人(30.5%)，轻度抑郁症状115人(51.6%)，中度抑郁29人(13.0%)，中重度抑郁7人(3.1%)，重度抑郁4人(1.8%)；抑郁阳性检出率为69.5%。一般自我效能感得分男性住培医师[(28.11±5.37)分]与女性住培医师[... | zh-cn |
pair_28216504 | To evaluate the safety, feasibility and effectiveness of laparoscopic-assisted resection of colorectal cancer without incision at abdomen vs the traditional laparoscopic resection.
Methods: We retrieved literature published from August, 2005 to August, 2015 to compare laparoscopic-assisted resection for colorectal can... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：评价腹腔镜下腹部无切口结直肠癌切除术较之传统腹腔镜下结直肠癌切除术的可行性和安全性。方法：检索2005年8月至2015年8月公开发表的腹腔镜下腹部无切口结直肠癌切除对比传统腹腔镜下结直肠癌切除术应用情况的文献。按纳入标准筛选后进行质量评分，提取临床效应指标，采用Review Maneger 5.3软件对所纳入的数据进行Meta分析。结果：最终纳入7项研究，共621例患者，其中无辅助切口组(NOSE组)262例，传统腹腔镜组(LAP组)359例。Meta分析结果显示总并发症发生率的对比NOSE组明显较LAP组少(OR=0.31，95% CI：0.18~0.53，P<0.05)。对并发症进行亚组分析，其中切口并发症NOSE组较LA... | zh-cn |
pair_28216506 | Dipeptidyl peptidase-4 (DPP-4) is known as a highly conserved type II transmembraneous glycoprotein widely distributed in a variety of tissues and cells, and expressed in the peripheral blood as a soluble form. It has been reported that DPP4 play a distinct role in the physiological and pathological processes, such as ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | DPP4是一种高度保守的II型跨膜糖蛋白，广泛分布于组织细胞并可以溶解形式存在于外周血。DPP4参与机体系列生理病理过程，如免疫调节、炎症反应、细胞黏附和细胞调亡等。DPP4抑制剂作为新开发的糖尿病药物在控制血糖尤其是餐后血糖方面效果显著。DPP4及其抑制剂还在多种呼吸系统疾病中具有潜在作用，尤其是在哮喘发病中可能发挥重要作用。. | zh-cn |
pair_28216507 | Cholesteatoma is a destructive and expanding growth benign tumor, mainly consisting of stratified squamous epithelium. It possesses the capacity of eroding bone and can exist in a nonaggressive state, remaining undetected for years. Once cholesteatoma appeared, it grows relentlessly and threats to invade intra-temporal... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胆脂瘤是一类主要由复层鳞状上皮细胞组成，少见的具有侵蚀性的先天性良性肿瘤。此肿瘤常成隐匿性起病，可侵蚀颅骨，因生长缓慢，可长期无明显症状，不易被发现。颅骨内起源的胆脂瘤大多发生于颞骨、中颅窝区域。1例误诊为皮脂腺囊肿伴感染的胆脂瘤患者，在中南大学湘雅二医院行手术治疗并病检确诊。该患者起病不典型，病变部位不典型，病变体积大，国内外罕有此部位巨大胆脂瘤占位的报道。. | zh-cn |
pair_28216508 | Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease and it is easy to be misdiagnosed, which is characterized by intestinal obstruction symptoms, such as abdominal pain, bloating and vomiting. In this study, a case of IMP was observed and the literatures were reviewed. Computed tomography shows funicular high... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 特发性肠系膜静脉硬化性肠炎在临床上十分罕见，通常以反复腹痛、腹胀、呕吐等肠梗阻症状多见，极易误诊。患者肠系膜断层扫描可见其典型的肠管周围沿血管走行的条索状高密度影，并可见血管钙化影，M-NBI肠镜可见蜂窝状的毛细血管网消失，微血管结构紊乱，血管密度增加。. | zh-cn |
pair_28219161 | Human infections with novel avian influenza A(H7N9)virus was an emerging infectious disease discovered in March, 2013. As of June30, 2016, 770 cases of H7N9 were reported in worldwide including 315 deaths with 40.9% of high case fatality rate. Yangtze River Delta and Pearl River Delta were the high-prevalence area. For... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 自2013年3月全球首次发现人感染H7N9禽流感患者以来，至2016年6月30日，中国内地共报告770例患者，其中死亡病例315例，病死率高达40.9%。长江三角和珠江三角地区是人感染H7N9禽流感的高发地区。以往的H7N9禽流感病例主要集中在大城市，但近期发现小城市和农村地区的患者比例不断升高。与季节性流感和H5N1禽流感一致，每一流行季的H7N9禽流感的发病高峰均集中在冬春季节。H7N9禽流感患者以中老年男性为主，年龄中位数为61岁。此外，人感染H7N9禽流感存在有限的非持续性的人际传播现象。目前，人感染H7N9禽流感已经历了4个流行季，且呈现周期性发展，没有停止的迹象。本文将分别从H7N9禽流感病毒的病原学、疾病分布、传播因素... | zh-cn |
pair_28219162 | Polybrominated diphenyl ethers (PBDEs), a kind of important Brominated Flame Retardant (BFR), are widely used in electronic products, construction materials and textiles. PBDEs have been detected in many environmental media (including air, water, dust, sediment and food), many animal and human tissues. For their enviro... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 多溴联苯醚（PBDEs）是一种重要的溴代阻燃剂，广泛应用于电子产品、建筑材料和纺织品中。同时，PBDEs已在多种环境介质（空气、水、土壤、沉积物和食物）、多种动物和人体组织中检出。因具有环境持久性、高生物蓄积性和多种生物毒性等性质，是目前备受关注的环境内分泌干扰物之一。PBDEs具有多方面毒性，其中,通过影响甲状腺激素，从而对机体所造成的内分泌干扰和神经发育毒性影响更是研究热点。本文从PBDEs的基本性质、使用现状、暴露情况及生物毒性展开叙述，并在生物毒性中重点围绕对甲状腺及甲状腺激素的影响，重点介绍与之相关的内分泌干扰和神经发育毒性。同时涉及到研究起步较晚PBDEs结构类似物（羟基多溴联苯醚和甲氧基多溴联苯醚）的初步介绍，为PBD... | zh-cn |
pair_28219178 | Cochlear implantation has become a crucial approach for the treatment for patients with severe and profound sensorineural hearing loss. However, some patients would be embarrassed by the exterior components, which limited the patient's social activities. The idea of totally implantable cochlear implant (TICI) was put f... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目前，人工耳蜗植入是重度和极重度感音神经性聋患者重获听力的重要手段。然而人工耳蜗体外机可能存在使用受限和给患者带来心理问题等劣势。据此，国内外专家提出'全植入'的理念，并认为其是一个可预见的发展趋势。可植入式声电换能器是全植入式人工耳蜗研究中亟待突破的核心问题，学者们提出了多种设计思路，本文将各种设计思路整理分析做一综述。. | zh-cn |
pair_28219179 | Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Ⅱ型固有淋巴细胞(typeⅡinnate lymphoid cells，ILC2)属于天然免疫淋巴细胞家族的一个成员，它可以提供有效的免疫效应细胞因子，从而启动后续的免疫反应。ILC2受核转录因子RORα和GATA3的调控，分泌细胞因子白细胞介素(IL)5和IL-13等。动物实验模型证明，ILC2参与了变态反应性疾病，如哮喘和变应性皮炎，而且在代谢平衡中扮演了十分重要的角色。此外，最近的研究表明，ILC2不仅在疾病的初始阶段发挥作用，也可以导致疾病的慢性病理改变，如纤维化等，并可对获得性免疫产生影响。本文主要对ILC2细胞的作用、调控及其在变应性鼻炎(AR)和慢性鼻-鼻窦炎(CRS)等慢性上呼吸道炎性疾病中的研究现状进行综述。. | zh-cn |
pair_28219181 | Head and neck squamous cell carcinoma(HNSCC) is the sixth most common malignancies of human beings. The prognosis of advanced HNSCC is poor despite improvements in traditional treatment strategies including surgery, chemotherapy, and radiotherapy. Cancer immunotherapy is the use of the immune system to treat cancer, wh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 头颈部鳞状细胞癌是人类第6大恶性肿瘤，目前主要的治疗手段包括手术、放化疗等对晚期进展病患的效果不甚理想。肿瘤免疫治疗是指应用各种免疫学方法，提高免疫效应细胞对肿瘤的靶向识别能力和免疫杀伤作用，以达到治疗肿瘤的目的，它没有典型的耐药性，且产生的疗效持久，正逐渐成为肿瘤的第四大治疗手段。本文就免疫治疗在头颈鳞癌的研究进展作一综述。. | zh-cn |
pair_28219182 | Circulating tumor cells are tumor cells from the primary tumor or metastatic tumor to fall off into the circulatory system. They are closely related to the recurrence and metastasis of tumor. Detection of circulating tumor cells as a 'liquid biopsy' , to get the tumor information through non-invasive sampling method. I... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 循环肿瘤细胞是指从原发肿瘤或转移灶脱落进入循环系统的肿瘤细胞。与肿瘤的复发、转移密切相关。循环肿瘤细胞的检测做为'液态活检'的一种，通过非侵入性的取样方式来获取肿瘤信息，确诊肿瘤时间短、可重复操作等优点，有逐渐取代传统活检的趋势。本文就循环肿瘤细胞的富集、检测及其在头颈部鳞状细胞癌中的应用做综述。. | zh-cn |
pair_28219199 | Lung cancer still remains the leading cause of cancer-related death worldwide. Recent development of molecular targeted therapies, especially the emergence of epidermal growth factor receptor (EGFR) inhibitors, has made an enormous progress for the treatment of non-small cell lung cancer (NSCLC). However, targeted ther... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年来，非小细胞肺癌分子病理诊断指导下的靶向治疗取得了巨大的进步，已成为临床标准治疗的一部分。然而，靶向治疗同时面临着获得性耐药等诸多问题。多项研究结果也表明，靶向治疗虽然能够明显延长患者的无疾病进展时间，但仍有许多需要改进之处。对于肿瘤治疗，真正实现精准医学仍然任重道远。文章针对精准医学对肺癌内科治疗的影响，以及如何在精准医学的背景下提高肺癌的内科治疗水平进行阐述，以期给广大肿瘤内科工作者带来一定的启示。. | zh-cn |
pair_28219200 | With the advances in molecular detection technology and the emergence of various targeted agents, we have entered the era of precision medicine across the whole process of cancer diagnosis and treatment. Tyrosine kinase inhibitors targeting epidermal growth factor receptor gene mutation, the most common driver, have be... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着分子检测技术的进步和靶向治疗药物的不断推出，肿瘤的诊疗已经进入到了精准化的全程管理时代。表皮生长因子受体(EGFR)作为最常见的驱动基因，其在中国非小细胞肺癌(NSCLC)患者中的阳性率约达50%。EGFR酪氨酸激酶抑制剂(EGFR-TKI)在NSCLC的临床治疗中扮演重要角色。第一代和第二代EGFR-TKI治疗已成为EGFR突变阳性晚期NSCLC患者的标准一线治疗，第三代EGFR-TKI也显示出良好的疗效，明显改善了晚期NSCLC患者的生存，提高了患者的生活质量。在精准医学背景下，第三代EGFR-TKI药物的应用策略值得关注。. | zh-cn |
pair_28219201 | EGFR tyrosine kinase inhibitors (TKIs) treatment has been established as standard therapy for EGFR-mutated adenocarcinomas. In the studies which published prospective randomized trials comparing EGFR TKIs with chemotherapy, a very low percentage of EGFR-mutated non-adenocarcinomas was enrolled in clinical trials. The e... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 酪氨酸激酶抑制剂(TKIs)是表皮生长因子受体(EGFR)突变肺腺癌的标准治疗。在既往有关TKIs的前瞻性随机对照临床研究中，EGFR突变的非腺癌非小细胞肺癌(NSCLC)的例数较少，其临床病理学特征以及与TKIs治疗相关性的研究不够充分。回顾性研究结果显示，非腺癌NSCLC的EGFR突变率低于腺癌，且TKIs的疗效也低于EGFR突变的肺腺癌，吸烟状态是预测EGFR突变非腺癌NSCLC患者TKIs疗效的主要因素。肺腺鳞癌的EGFR突变率和TKIs疗效优于EGFR突变的鳞癌或大细胞癌。在中国大陆人群中，非腺癌NSCLC的EGFR突变率并非很低，EGFR－TKIs作为EGFR突变非腺癌尤其腺鳞癌和非吸烟患者的一个重要治疗选择是合理的。有... | zh-cn |
pair_28219202 | Recently, with the research progress in molecular classification, the treatment of advanced non-small cell lung cancer (NSCLC) has been established as a model of anti-tumor treatment of precision medicine. The discovery of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) has transformed the treatm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年来，分子分型的研究进展使得晚期非小细胞肺癌(NSCLC)成为精准医学时代抗肿瘤诊疗的典范和标杆。表皮生长因子受体酪氨酸酶抑制剂(EGFR－TKI)使晚期NSCLC的治疗从标准含铂双药的化疗时代进入靶向治疗时代，以吉非替尼和厄洛替尼为代表的第一代EGFR－TKI已成为EGFR敏感突变阳性患者的一线首选治疗药物。然而耐药问题始终如影随形。从临床角度看，耐药后进展模式可分为快速进展、缓慢进展和局部进展3种模式。从分子机制上看，耐药机制包括EGFR 20外显子T790M突变、MET基因扩增、小细胞转化、上皮－间叶转化和PIK3CA突变等，其中以20外显子T790M突变最为常见。文章就EGFR敏感突变阳性的晚期NSCLC EGFR－TKI... | zh-cn |
pair_28219203 | Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have become the preferred treatment option for advanced non-small-cell lung cancer (NSCLC) patients with activating mutations in epidermal growth factor receptor (EGFR) according to major practice guidelines. Gefitinib, elortinib and icotinib for... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 对于表皮生长因子受体(EGFR)敏感突变的非小细胞肺癌(NSCLC)患者，一线选择EGFR酪氨酸激酶抑制剂(TKI)已成为各指南的首选治疗方案。在我国的临床实践中，吉非替尼、厄洛替尼和埃克替尼形成了一线EGFR-TKI治疗NSCLC的基础。然而，新的TKI药物层出不穷，关于阿法替尼、AZD9291等的临床研究结果不断公布，更多的药物有可能成为EGFR敏感突变患者的一线选择。同时，基因检测技术不断发展，人们对于NSCLC的分子生物学行为有了更为广泛的认知，TKI的耐药机制也逐步清晰。因此，对于EGFR突变晚期NSCLC患者一线治疗的精准化，就有了更多可探究之处。. | zh-cn |
pair_28228217 | T peptide is extensively used in anti-tumor treatment. The aims of this study were to investigate whether T peptide enhances cisplatinum efficiency while reducing its side effects and to identify its effective mechanisms. (1) Human macrophage U937 cells were treated with T peptide and/or cisplatinum. The levels of tumo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 T肽是Tuftsin的衍生物，其基本功能是刺激巨噬细胞，提高巨噬细胞吞噬及分泌能力，通过增强效应细胞的细胞杀伤作用而被广泛用于多种恶性肿瘤术后抗肿瘤治疗。本研究旨在探讨T肽与化疗药物顺铂的联合能否提高铂类药物的抗肿瘤疗效及机制。方法 应用酶联免疫吸附剂测定（enzyme-linked immunosorbent assay, ELISA）T肽和/或顺铂处理人巨噬细胞株U937后肿瘤坏死因子-α（tumor necrosis factor-α, TNF-α）和干扰素-γ（interferon-γ, IFN-γ）分泌水平的变化；应用裸鼠荷瘤动物模型，分析T肽和/或顺铂处理小鼠肿瘤变化情况以及小鼠用药期间外周血中巨噬细胞变化情... | zh-cn |
pair_28228219 | Small cell lung cancer (SCLC) accounts for nearly 15% of all cases of cancer. As a type of highly invasive tumors, SCLC has high degree of malignancy, early and extensive metastasis, and is sensitive to chemotherapy and radiotherapy. The early treatment response rate of SCLC is high but it can also relapse rapidly with... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 小细胞肺癌（small cell lung cancer, SCLC）占所有肺癌的比例近15%左右。SCLC作为一种高度侵袭性肿瘤，恶性程度高，转移早而广泛，对化疗、放疗敏感，初治缓解率高，但容易复发，如果未经任何治疗，其中位生存期仅为4个月-6个月。近年来对SCLC开展了许多研究，但仍未改变SCLC的临床治疗策略，治疗上仍局限于诸如足叶乙甙+顺铂（EP）或卡铂（CE）化疗方案等一些经典的治疗手段，对手术治疗在SCLC治疗，尤其是IIIa期的治疗仍未达成共识。本研究旨在探讨IIIa期SCLC的外科手术为主的综合治疗对SCLC的临床治疗效果及对影响预后的因素。方法 通过回顾性分析1995年1月-2010年12月首都医科大学... | zh-cn |
pair_28228221 | The therapeutic effect and side effect of neoadjuvant chemotherapy were still disputing issues when applied to resectable IIIa stage non-small cell lung cancer (NSCLC) patients. The retrospective analysis was aimed to investigate the short-term efficacy and postoperative complications in resectable IIIa NSCLC patients ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 新辅助化疗应用于可手术切除的IIIa期非小细胞肺癌（non-small cell lung cancer, NSCLC）患者的确切疗效及安全性尚存争议。本研究旨在探讨新辅助化疗对可手术切除IIIa期NSCLC患者的近期疗效，并分析其与术后并发症的相关性。方法 根据纳入及排除标准，回顾性分析2011年1月-2013年10月重庆医科大学附属第一医院收治的明确临床诊断为IIIa期NSCLC 370例患者完整资料，根据术前是否接受新辅助化疗分为两组，其中A组为新辅助化疗+手术组97例，B组为直接手术组273例，比较两组患者的临床资料，分析新辅助化疗后肿瘤降期率，并将两组患者的手术情况、术后并发症进行对比，统计两组患者3年无病生存... | zh-cn |
pair_28228222 | With the popularization of high-resolution computed tomography (HRCT), there is a rising trend of the detection of multiple primary lung cancers (MPLC). Adenocarcinomas is the major pathological type of MPLC. At present, reports on MPLC are relatively common, but few study focused on synchronous multiple primary lung a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 随着高分辨率计算机断层扫描（high-resolution computed tomography, HRCT）应用的普及，多原发肺癌（multiple primary lung cancers, MPLC）的检出率逐年上升，其中腺癌是最常见的病理类型。目前国内外对MPLC的研究已相对多见，但罕有单独分析同时性多原发肺腺癌（synchronous multiple primary lung adenocarcinomas, SMPLA）的报道。本研究探讨SMPLA患者的临床病理特点及预后，旨在提高对SMPLA的认识。方法 对2012年12月-2016年7月期间我科38例临床资料保存完整的SMPLA患者进行了回顾性分析。结... | zh-cn |
pair_28228225 | Isolation and characterization of lung epithelial stem and progenitor cells and understanding of their specific role in lung physiopathology are critical for preventing and controlling lung diseases including lung cancer. In this review, we summarized recent advances in classification and research methods of lung epith... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_34033147 | Canine cutaneous epitheliotropic T-cell lymphoma (CETL) is associated with a poor prognosis and without consistently beneficial treatment options. This case report describes a 9-year-old Staffordshire bull terrier with CETL treated with oclacitinib (0.7 mg/kg twice daily), resulting in partial remission that was mainta... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 犬皮肤趋上皮性T细胞淋巴瘤(CETL)的预后不良，且无一致有效的治疗方案。本病例报告描述了1只9岁的斯塔福牛头㹴，CETL接受了奥拉替尼（0.7 mg/kg，每日两次）治疗，可见部分缓解，并维持3个月。此方案需要进一步研究。. | zh-cn |
pair_34033147 | Canine cutaneous epitheliotropic T-cell lymphoma (CETL) is associated with a poor prognosis and without consistently beneficial treatment options. This case report describes a 9-year-old Staffordshire bull terrier with CETL treated with oclacitinib (0.7 mg/kg twice daily), resulting in partial remission that was mainta... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Le lymphome cutané T épithéliotrope canin (CETL) est associé à un pronostic faible et sans option thérapeutique bénéfique constante. Ce cas clinique décrit un Staffordshire bull-terrier de 9 ans avec CETL traité avec oclacitinib (0,7 mg/kg deux fois par jour), résultant en une rémission partielle qui s’est maintenue tr... | fr |
pair_34033147 | Canine cutaneous epitheliotropic T-cell lymphoma (CETL) is associated with a poor prognosis and without consistently beneficial treatment options. This case report describes a 9-year-old Staffordshire bull terrier with CETL treated with oclacitinib (0.7 mg/kg twice daily), resulting in partial remission that was mainta... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Das kutane epitheliotrope T-Zell Lymphom (CETL) des Hundes hat eine schlechte Prognose und es gibt keine beständigen günstigen Behandlungsoptionen. Dieser Fallbericht beschreibt einen 9 Jahre alten Staffordshire Bullterrier mit CETL, der mit Oclacitinib (0,7 mg/kg zweimal täglich) behandelt wurde, was in einer teilweis... | de |
pair_34033147 | Canine cutaneous epitheliotropic T-cell lymphoma (CETL) is associated with a poor prognosis and without consistently beneficial treatment options. This case report describes a 9-year-old Staffordshire bull terrier with CETL treated with oclacitinib (0.7 mg/kg twice daily), resulting in partial remission that was mainta... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | O linfoma epiteliotrópico canino de células T (CETL) está associado a um mau prognóstico e sem opções de tratamento consistentemente benéficas. Este relato de caso descreve um Staffordshire bull terrier de 9 anos de idade com CETL tratado com oclacitinib (0,7 mg/kg duas vezes ao dia), resultando em remissão parcial que... | pt |
pair_34033147 | Canine cutaneous epitheliotropic T-cell lymphoma (CETL) is associated with a poor prognosis and without consistently beneficial treatment options. This case report describes a 9-year-old Staffordshire bull terrier with CETL treated with oclacitinib (0.7 mg/kg twice daily), resulting in partial remission that was mainta... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El linfoma epiteliotrópico cutáneo de células T canino (CETL) se asocia con un mal pronóstico y sin opciones de tratamiento consistentemente beneficiosas. Este informe de caso describe un Staffordshire bull terrier de 9 años con CETL tratado con oclacitinib (0,7 mg/kg dos veces al día), lo que resultó en una remisión p... | es |
pair_34033155 | Otitis externa is associated with a lack of bacterial/fungal diversity in atopic dermatitis. Clinical experience has shown that use of topical corticosteroids in the ear canal (EC) can prevent otitis. No data are available on the impact of this treatment on the EC microbiota. To observe the bacterial/fungal diversity i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 特应性皮炎的外耳炎细菌/真菌多样性降低。临床经验表明, 给耳道(EC)使用皮质类固醇可预防耳炎。尚无关于该治疗对EC微生物群影响的数据。 假设/目的: 观察EC中的细菌/真菌多样性和无活动性耳炎的特应性犬耳道给予皮质类固醇4周的临床效果。 动物: 10只特应性犬, 不伴随活动性耳炎。 方法和材料: 在右侧EC应用莫米松, 而左侧作为对照。对EC进行了临床和细胞学评价。使用新一代测序方法分析每个EC的拭子。 结果: 在试验开始时, 观察在犬之间以及个体内微生物群和真菌区系的变化。在统计学上, 随着时间的推移, 在治疗组和未治疗组之间未观察到α和β多样性的显著差异。临床上, 第(D)28天的左右EC多样性无差异(P = 0.28... | zh-cn |
pair_34033155 | Otitis externa is associated with a lack of bacterial/fungal diversity in atopic dermatitis. Clinical experience has shown that use of topical corticosteroids in the ear canal (EC) can prevent otitis. No data are available on the impact of this treatment on the EC microbiota. To observe the bacterial/fungal diversity i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’otite externe est associée à un manque de diversité bactérienne/fongique dans la dermatite atopique. L’expérience clinique a montré que l’utilisation de corticoïdes topiques dans le conduit auriculaire (EC) peut prévenir l’otite. Aucune donnée n’était disponible sur l’impact de ce traitement sur le microbiote EC. HYP... | fr |
pair_34033155 | Otitis externa is associated with a lack of bacterial/fungal diversity in atopic dermatitis. Clinical experience has shown that use of topical corticosteroids in the ear canal (EC) can prevent otitis. No data are available on the impact of this treatment on the EC microbiota. To observe the bacterial/fungal diversity i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Otitis externa wird mit einem Mangel an Diversität von Bakterien/Pilzen bei der atopischen Dermatitis in Zusammenhang gebracht. Die klinische Erfahrung hat gezeigt, dass die Verwendung topischer Cortikosteroide im Ohrkanal (EC) eine Otitis verhindern kann. Es gibt keine Daten über den Einfluss dieser Behandlung auf... | de |
pair_34033155 | Otitis externa is associated with a lack of bacterial/fungal diversity in atopic dermatitis. Clinical experience has shown that use of topical corticosteroids in the ear canal (EC) can prevent otitis. No data are available on the impact of this treatment on the EC microbiota. To observe the bacterial/fungal diversity i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A otite externa está associada à redução de diversidade bacteriana/fúngica na dermatite atópica. A experiência clínica mostrou que o uso de corticosteroides tópicos no conduto auditivo (CA) pode prevenir a otite. Não existem dados disponíveis sobre o impacto deste tratamento na microbiota da CA. HIPÓTESES/OBJETIVOS: Ob... | pt |
pair_34033155 | Otitis externa is associated with a lack of bacterial/fungal diversity in atopic dermatitis. Clinical experience has shown that use of topical corticosteroids in the ear canal (EC) can prevent otitis. No data are available on the impact of this treatment on the EC microbiota. To observe the bacterial/fungal diversity i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la otitis externa se asocia con una falta de diversidad bacteriana/fúngica en dermatitis atópica. La experiencia clínica ha demostrado que el uso de corticosteroides tópicos en el canal auditivo (EC) puede prevenir la otitis. No se dispone de datos sobre el impacto de este tratamiento en la microbiota de la EC. HIPÓTES... | es |
pair_34033160 | Erythema multiforme is a rare hypersensitivity reaction that is reported in several domestic animal species, and not in goats. This case report describes the clinical and histopathological features of erythema multiforme and secondary bacterial skin infection in a goat. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 多形红斑是一种罕见的超敏反应, 在几种家畜种属中均有报告, 但在山羊中未见报告。本病例报告描述了山羊多形红斑和继发性细菌性皮肤感染的临床和组织病理学特征。. | zh-cn |
pair_34033160 | Erythema multiforme is a rare hypersensitivity reaction that is reported in several domestic animal species, and not in goats. This case report describes the clinical and histopathological features of erythema multiforme and secondary bacterial skin infection in a goat. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Un érythème polymorphe est une réaction d ‘hypersensibilité rare décrite chez plusieurs espèces d’animaux domestiques mais pas chez la chèvre. Cet article décrit les données cliniques et histopathologiques d’un érythème polymorphe et d’une infection bactérienne secondaire chez une chèvre. | fr |
pair_34033160 | Erythema multiforme is a rare hypersensitivity reaction that is reported in several domestic animal species, and not in goats. This case report describes the clinical and histopathological features of erythema multiforme and secondary bacterial skin infection in a goat. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Das Erythema multiforme ist eine seltene Hypersensibilitätsreaktion, die bei verschiedenen Haustierspezies, jedoch nicht bei Ziegen, beschrieben wurde. Dieser Fall beschreibt die klinischen und histopathologischen Merkmale eines Erythema multiforme und einer sekundären bakteriellen Hautinfektion bei einer Ziege. | de |
pair_34033160 | Erythema multiforme is a rare hypersensitivity reaction that is reported in several domestic animal species, and not in goats. This case report describes the clinical and histopathological features of erythema multiforme and secondary bacterial skin infection in a goat. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | O eritema multiforme é uma reação de hipersensibilidade rara relatada em várias espécies de animais domésticos, e não em cabras. Este relato de caso descreve as características clínicas e histopatológicas de eritema multiforme e infecção bacteriana secundária da pele em uma cabra. | pt |
pair_34033160 | Erythema multiforme is a rare hypersensitivity reaction that is reported in several domestic animal species, and not in goats. This case report describes the clinical and histopathological features of erythema multiforme and secondary bacterial skin infection in a goat. | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El eritema multiforme es una reacción de hipersensibilidad rara que se ha descrito en diversas especies de animales domésticos, pero no en cabras. Este artículo describe las características clínicas e histopatológicas de eritema multiforme e infección cutánea bacteriana secundaria en una cabra. | es |
pair_34033172 | Diagnosis of adverse food reaction (AFR) is based on an eight week elimination diet (ED) and is confirmed by relapse upon re-challenge with the previously fed diet. Hydrolysed EDs are commonly used for this purpose. To evaluate the commercially available hydrolysed fish protein and rice starch ED Farmina UltraHypo (FUH... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 食物不良反应(AFR)的诊断是基于8周食物排查(ED)，并通过之前喂食的日粮再激发后复发来证实。水解ED通常用于此目的。 目的: 评价市售水解鱼蛋白和大米淀粉ED Farmina UltraHypo(FUH)用于猫AFR的诊断。 动物: 32只非季节性瘙痒猫。 方法: 在第0天和第56天，使用新的双重直观模拟量表评估瘙痒，使用猫过敏性皮炎量表评估病变，使用经验证的问卷评估生活质量。在前6周内允许使用短效皮质类固醇或奥拉替尼。使用先前的日粮、鱼和大米分别对瘙痒和/或病变改善50%的猫进行激发。对研究日粮无反应的猫喂食另一种水解日粮2个月。 结果: 25只猫完成了ED：4只因呕吐和/或腹泻退出，1只因适口性低退出，2只失访。17... | zh-cn |
pair_34033172 | Diagnosis of adverse food reaction (AFR) is based on an eight week elimination diet (ED) and is confirmed by relapse upon re-challenge with the previously fed diet. Hydrolysed EDs are commonly used for this purpose. To evaluate the commercially available hydrolysed fish protein and rice starch ED Farmina UltraHypo (FUH... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Le diagnostic de réaction alimentaire indésirable (AFR) est basée sur un régime d’éviction de huit semaines (ED) et est confirmé par un test de proc-vocation avec l’alimentation précédente. Les EDs hydrolysées sont fréquemment utilisées à cet effet. Evaluer l’aliment FUH (Farmina UltraHypo) composé de protéines de pois... | fr |
pair_34033172 | Diagnosis of adverse food reaction (AFR) is based on an eight week elimination diet (ED) and is confirmed by relapse upon re-challenge with the previously fed diet. Hydrolysed EDs are commonly used for this purpose. To evaluate the commercially available hydrolysed fish protein and rice starch ED Farmina UltraHypo (FUH... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Diagnose einer Futtermittelnebenwirkung (AFR) basiert auf einer acht-wöchigen Eliminationsdiät (ED) und wird durch ein Wiederauftreten nach einer Provokation mit dem zuvor gefütterten Futter bewiesen. Hydrolysierte EDs werden häufig zu diesem Zweck eingesetzt. ZIEL: Die Evaluierung einer kommerziell erhältlichen hy... | de |
pair_34033172 | Diagnosis of adverse food reaction (AFR) is based on an eight week elimination diet (ED) and is confirmed by relapse upon re-challenge with the previously fed diet. Hydrolysed EDs are commonly used for this purpose. To evaluate the commercially available hydrolysed fish protein and rice starch ED Farmina UltraHypo (FUH... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | O diagnóstico de reação adversa a alimentos (AFR) é baseado em uma dieta de eliminação (DE) de oito semanas e é confirmado por recidiva após nova provocação com a dieta fornecida anteriormente. DEs hidrolisados são comumente usados para esse propósito. Avaliar a DE à base de proteína hidrolisada de peixe e o amido ... | pt |
pair_34033172 | Diagnosis of adverse food reaction (AFR) is based on an eight week elimination diet (ED) and is confirmed by relapse upon re-challenge with the previously fed diet. Hydrolysed EDs are commonly used for this purpose. To evaluate the commercially available hydrolysed fish protein and rice starch ED Farmina UltraHypo (FUH... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | el diagnóstico de reacción adversa a los alimentos (AFR) se basa en una dieta de eliminación (ED) de ocho semanas y se confirma mediante una recaída al volver a exponer a la dieta previamente alimentada. Los ED hidrolizados se utilizan comúnmente para este propósito. OBJETIVO: Evaluar la proteína de pescado hidrolizada... | es |
pair_34033174 | Persian cats are predisposed to chronic and severe dermatophytosis. Alterations to the cutaneous microbiota are one potential contributor to this predisposition. To characterise the cutaneous and environmental fungal microbiota of Persian cats with chronic, severe dermatophytosis, and to compare the fungal microbiota o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 波斯猫易患慢性和重度皮肤癣菌病。皮肤微生物群的改变是导致这种易感性的可能因素。 目的: 描述患有慢性、严重皮肤癣菌病的波斯猫的皮肤和环境真菌菌群, 并比较患有和未患有皮肤癣菌病的猫的真菌菌群。 动物: 36只客户拥有的猫, 包括26只波斯猫和10只家养长毛(DLH)猫。 方法和材料: 从患有严重、慢性皮肤癣菌病的波斯猫以及健康对照猫组 (波斯和DLH) 中采集皮肤和家庭环境拭子。除ITS1定量PCR和真菌培养外, 还进行内转录间隔区1(ITS1)区测序。 结果: 靶向真菌ITS区的新一代测序(NGS)检测到小孢子菌。所有被诊断为皮肤癣菌病的波斯猫和他们家的环境样本的DNA。在病例组和对照组之间发现了群落结构的显著差异, 主要... | zh-cn |
pair_34033174 | Persian cats are predisposed to chronic and severe dermatophytosis. Alterations to the cutaneous microbiota are one potential contributor to this predisposition. To characterise the cutaneous and environmental fungal microbiota of Persian cats with chronic, severe dermatophytosis, and to compare the fungal microbiota o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les chats persans sont prédisposés à la dermatophytose sévère et chronique. Les altérations du microbiote cutané sont un des facteurs potentiels contribuant à cette prédisposition. Caractériser le microbiote cutané et environnemental fongique des persans atteints de dermatophytose chronique sévère et comparer le microb... | fr |
pair_34033174 | Persian cats are predisposed to chronic and severe dermatophytosis. Alterations to the cutaneous microbiota are one potential contributor to this predisposition. To characterise the cutaneous and environmental fungal microbiota of Persian cats with chronic, severe dermatophytosis, and to compare the fungal microbiota o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Perserkatzen sind prädisponiert dazu, an einer chronischen und schweren Dermatophytose zu erkranken. Veränderungen des Mikrobioms der Haut sind möglicherweise an dieser Prädisposition beteiligt. Eine Beschreibung der mykotischen Mikrobiota der Haut und der Umgebung von Perserkatzen mit chronischer, schwerer Dermatophyt... | de |
pair_34033174 | Persian cats are predisposed to chronic and severe dermatophytosis. Alterations to the cutaneous microbiota are one potential contributor to this predisposition. To characterise the cutaneous and environmental fungal microbiota of Persian cats with chronic, severe dermatophytosis, and to compare the fungal microbiota o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Os gatos persas são predispostos à dermatofitose crônica e grave. Alterações na microbiota cutânea são um potencial contribuinte para essa predisposição. Caracterizar a microbiota cutânea fúngica e ambiental de gatos persas com dermatofitose crônica grave e comparar a microbiota fúngica de gatos com e sem dermatofitose... | pt |
pair_34033174 | Persian cats are predisposed to chronic and severe dermatophytosis. Alterations to the cutaneous microbiota are one potential contributor to this predisposition. To characterise the cutaneous and environmental fungal microbiota of Persian cats with chronic, severe dermatophytosis, and to compare the fungal microbiota o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | los gatos persas están predispuestos a la dermatofitosis crónica y grave. Las alteraciones de la microbiota cutánea son un contribuyente potencial a esta predisposición. Caracterizar la microbiota fúngica cutánea y ambiental de gatos persas con dermatofitosis crónica severa y comparar la microbiota fúngica de gatos con... | es |
pair_34034367 | The Civil Code of the People's Republic of China (hereinafter referred to as the 'Civil Code') has been implemented on January 1, 2021. The 'Civil Code' involves clinical medical diagnosis and treatment work legal norms and legal liabilities. Except for the revisions of the key contents of the 'Medical Damage Liability... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 《中华人民共和国民法典》（以下简称《民法典》）已于2021年1月1日实施。《民法典》中涉及临床医学诊疗工作法律规范以及法律责任除对《侵权责任法》“医疗损害责任”部分关键内容进行了修订外，大部分沿用原有规定。为了使医疗机构的管理者、医务人员全面了解《民法典》的有关规定及其临床应用，本文分10个部分进行全面系统解读。. | zh-cn |
pair_34034373 | The clinical features, imaging features, treatment methods and pathological features of 27 patients with metanephric adenoma were analyzed. It was found that the clinical features and imaging features of metanephric adenoma were difficult to differentiate from renal malignantology. Pathology can be clearly diagnosed an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 分析了27例后肾腺瘤患者的临床特征、影像学表现、治疗方式及病理学特点，发现后肾腺瘤临床特征及影像学表现难以与肾恶性肿瘤鉴别，病理可明确诊断，部分可合并恶性成分。保留肾单位手术为首选手术方式，预后良好，但仍需定期随访。. | zh-cn |
pair_34034394 | The incidence of food allergy is gradually increasing worldwide, and food allergy are receiving more and more attention. Food allergies can not only cause eczema in infants and young children, but can also cause severe allergic reactions and even death. However, the current treatment of food allergy is still lack of sp... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 食物过敏发生率正逐年升高，其不仅可导致婴幼儿湿疹，还可以引起严重过敏反应，甚至导致死亡。然而，当前针对食物过敏还缺乏特效的治疗方法，仍以回避过敏食物为主。因此，如何预防食物过敏成为越来越被关注的议题。近年来，学者们相继开展高质量的临床研究以评价婴幼儿食物早期摄入对于预防食物过敏的作用，取得了令人振奋的结果，并且由此改变了婴幼儿喂养指南的相关内容。本文对近年来开展的常见食物（例如花生、鸡蛋、牛奶等）的早期摄入预防食物过敏的最新研究进行分析，以期可为预防食物过敏带来新的思路和视角。. | zh-cn |
pair_34034395 | Anaphylaxis is increasingly in children. Foods are the most common triggers. Anaphylaxis is currently undernotified, underdiagnosed, and undertreated in China. Recurrence of anaphylaxis has been recorded in one-third of cases, thus it is essential to prevent recurrence in long-term personalized management of anaphylaxi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 严重过敏反应在儿童发病率逐年升高。食物是儿童严重过敏反应的主要诱因。目前我国对儿童严重过敏反应存在认识不足，诊断不足，治疗不足的问题，约1/3儿童严重过敏反应可反复发作。个体化长期管理对预防儿童严重过敏反应再次发作至关重要。本文从规避诱因、识别早期症状、长程管理危险因素及管理伴发因素进行阐述，旨在提高临床医师对儿童严重过敏反应的认识、规范诊疗和长程管理、预防复发。. | zh-cn |
pair_34034396 | Adverse drug reactions are often encountered in the process of medication and are quite troublesome for clinicians. Skin is one of the most frequently affected organs by adverse drug reactions. Adverse drug reactions involving skin are called 'drug-induced dermatitis' or 'drug eruption'. In some rare instances, drug er... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 药物不良反应是用药过程中常遇到的且十分困扰临床医生的问题，皮肤是药物不良反应最常累及的器官之一。药物不良反应累及皮肤称之为“药物性皮炎”，即“药疹”，少数情况下甚至会出现累及生命的重症药疹，但由于临床混合用药的情况导致真实的致敏药物难以明确，致使临床治疗中多种药物无法使用。随着基因组学的发展，许多研究发现人类白细胞抗原（human leukocyte antigen，HLA）等位基因和特定药物导致的药疹发病有着密切联系，用药前进行HLA风险基因筛查可显著降低相关药物重症药疹的发病率，但HLA基因筛查仅能预防有限的药物导致的重症药疹，大多数药物尚未发现HLA风险基因位点，因此只能通过其他检查明确致敏药物。目前药物激发试验在国际上被认为... | zh-cn |
pair_34034397 | Parenteral nutrition plays an important role in the early growth and development of preterm infants. Milk protein is the main protein source for enteral nutrition in preterm infants. Although the incidence of cow's milk protein allergy (CMPA) in preterm infants is relatively low, the symptoms are atypical and easily co... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肠内外营养在早产儿早期生长发育过程中发挥重要作用，牛奶蛋白是早产儿肠内营养的主要蛋白质来源。早产儿牛奶蛋白过敏（cow′s milk protein allergy，CMPA）发生率虽然相对低，但症状不典型，易与其他疾病混淆，导致实施不恰当的诊疗措施，严重影响早产儿生长发育和预后。因此，本文通过阐述早产儿CMPA的流行病学、临床表现、辅助检查、诊断及鉴别诊断、治疗及预防研究进展，发现早产儿CMPA起病时间晚，单纯表现为直肠出血者较少，表现胆汁样呕吐及类似于坏死性小肠结肠炎的症状更为常见，主要依据诊断性回避试验做出诊断，对于确诊CMPA的患儿，应通过母亲饮食回避、更换为深度水解配方奶或氨基酸配方奶治疗。但就如何早期识别早产儿CMPA仍... | zh-cn |
pair_34034398 | Food allergy is a global problem. Peanut is one of the most common food allergens that can result in anaphylaxis, even with milligram exposure. Most peanut allergies could persist lifelong. The current standard of care for peanut allergy is strict dietary avoidance and immediate treatment of allergic reaction triggered... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 食物过敏已成为全球性的健康问题。花生是最常见的食物过敏原之一，即使微量的暴露也可导致严重过敏反应。绝大多数的花生过敏可持续终身。目前对花生过敏患者的管理是严格的过敏原回避和意外暴露后的及时治疗。口服免疫治疗（oral immunotherapy，OIT）通过调节免疫系统可诱导发生过敏反应阈值的提高。近年来临床医生开始探索花生OIT来保护花生过敏患者发生严重甚至危及生命的过敏反应。本文将从花生OIT的机制、疗效、安全性及对生活质量的影响等方面进行阐述。. | zh-cn |
pair_34034411 | To investigate the diversity and composition of gut microbiota in patients with lung adenocarcinoma and lung squamous cell carcinoma. A single-center and case-control study was conducted to consecutively enroll a total of 27 lung cancer patients, including 15 males and 12 females, who were seen at the Affiliated Hangzh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨肺腺癌和肺鳞癌患者肠道菌群结构的多样性及构成。采用单中心病例对照研究，连续入组2018年9月至2020年10月就诊于浙江大学医学院附属杭州市第一人民医院的肺癌患者共27例，其中男性15例，女性12例，同期招募健康体检者作为对照组（HC）共20例，其中男性9例，女性11例。收集研究对象新鲜粪便样本及相关临床资料，根据病理诊断结果将肺癌患者分为肺腺癌组（AC，纳入19例患者，其中男性8例，女性11例）和肺鳞癌组（SCC，纳入8例患者，其中男性7例，女性1例）。提取粪便样本基因组DNA，对16S rDNA V3-V4区域进行PCR扩增，通过Illumina MiSeq 高通量测序平台进行测序，应用QIIME分析肠道菌群结构。采用方差分... | zh-cn |
pair_34034412 | To explore the expression of p62 protein in lung adenocarcinoma (LUAD). In this study, a cross-sectional study was adopted. From December 2011 to May 2013, 60 patients with lung adenocarcinoma who were diagnosed and treated in Tongji Hospital of Tongji University, Shanghai were selected for paraffin embedding and tissu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨p62蛋白在肺腺癌（lung adenocarcinoma，LUAD）中的表达情况。采用横断面研究，选择2011年12月至2013年5月上海市同济大学附属同济医院诊治的60例肺腺癌患者组织标本进行石蜡包埋和组织芯片制作，采用免疫组织化学技术（immunohistochemistry，IHC）检测肺腺癌患者癌组织和癌旁组织中p62的表达，分析p62表达与肺腺癌患者临床病理特征及生存预后的关系；同时以随机抽样的方式选取6例肺腺癌癌组织和癌旁组织通过蛋白免疫印迹（Western Blot，WB）检测p62蛋白并进行灰度值分析。收集2018年4月至2019年10月初诊的肺腺癌住院患者术前检查标本，以及健康体检者血浆标本，酶联免疫吸附法（... | zh-cn |
pair_34034414 | The purpose of this study is to explore the smoking-related behaviors of people ≥60 years of age with respiratory diseases in Shangqiu area. A total of 550 patients with respiratory diseases ≥60 years old who were treated at the First People's Hospital of Shangqiu from April 2015 to April 2017 were selected as the surv... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨商丘地区≥60岁呼吸系统疾病人群吸烟相关行为状况。收集2015年4月至2017年4月在商丘市第一人民医院就诊的≥60岁呼吸系统疾病患者550例作为调查对象，其中男351例，女199例；年龄60~86（72.85±5.71）岁。随访至2020年4月，随访3年及以上，收集相关信息及死亡信息。采用多因素Cox比例风险回归模型分析调查对象吸烟行为对≥60岁呼吸系统疾病人群死亡风险的影响。共纳入调查人数550例，剔除失访病例25例，有效人数525例，调查有效率95.45%；525例患者中，男336例（64.00%），女189例（36.00%）；年龄60~86（72.69±5.64）岁，受教育程度以高中及中专为主，占全部人数的39.24%，... | zh-cn |
pair_34034415 | Gastric cancer is a malignant tumor with high morbidity and mortality, which is a serious threat to human life and health. At present, the diagnosis and course monitoring of gastric cancer mainly rely on gastroscopic biopsy and CT, but their invasiveness and delay limit their clinical value. Gastric cancer patients urg... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胃癌是一种发病率和死亡率都很高的恶性肿瘤，严重威胁着当今人类的生命健康。目前，胃癌的诊断和病程监测主要依靠胃镜活检和影像学检查，但侵入性和迟滞性限制了它们的临床价值，胃癌患者急需一种实时、精确、非侵入的诊断和病程监测方法。循环肿瘤DNA（ctDNA）是由肿瘤细胞释放到体液中的单链或双链DNA，含有与原始肿瘤细胞相同的基因突变，也是新近出现的生物学标志物之一。随着下一代测序（NGS）技术的出现和发展，ctDNA检测的敏感度和特异度不断提升，正逐渐成为肿瘤诊断和病程监测的新选择。本文就目前下一代测序技术检测ctDNA在胃癌诊断和治疗中的应用进行阐述。. | zh-cn |
pair_34034456 | Epidermal growth factor receptor (EGFR) is the gene with the highest mutation rate in non-small cell lung cancer (NSCLC) patients, and the accurate evaluation of its mutational status can facilitate patients receiving targeted drug therapy and thereby prolong patients' survival. The gene testing platform has adequacy r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：非小细胞肺癌小活检标本质量与EGFR基因突变检出率关系分析】 【中文摘要：背景与目的 表皮生长因子受体（epidermal growth factor receptor, EGFR）是非小细胞肺癌（non-small cell lung cancer, NSCLC）患者中突变率最高的基因，准确检测出其突变类型有助于指导患者接受靶向药物治疗从而延长患者生存期。为了得到准确的检查结果，基因检测平台对标本质量有一定要求。已有文献报道标本的肿瘤细胞数量及其比例等会影响EGFR基因突变检出率，本研究旨在分析NSCLC小活检标本质量与突变扩增系统（amplification refractory mutation system, A... | zh-cn |
pair_34034457 | Immune checkpoint inhibitor monotherapy is reported to have little effect in advanced non-small cell lung cancer (NSCLC) patients with driver oncogenes. However, recent studies have shown that some patients with driver genes are still benefit from combination immunotherapy after tyrosine kinase inhibitors (TKIs) drug r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：EGFR突变晚期非小细胞肺癌患者后线
接受免疫治疗的疗效分析】 【中文摘要：背景与目的 免疫检查点抑制剂单药治疗在驱动基因阳性的晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）患者中疗效甚微。研究表明，部分驱动基因阳性患者靶向治疗耐药后对免疫联合治疗仍有效。国内研究甚少。本研究旨在分析人表皮生长因子（epidermal growth factor receptor, EGFR）敏感突变NSCLC患者后线接受免疫治疗的疗效，评价真实世界免疫联合化疗在EGFR突变晚期患者后线治疗中的价值。方法 收集2018年6月-2020年11月在首都医科大学附属北京胸科医院确诊的EGFR突变的初治晚期... | zh-cn |
pair_34034458 | There is a certain correlation between vitamin nutritional status and cancer patients. Studies have shown that vitamin deficiency increases the risk of cancer. The purpose of this study is to understand the vitamin D nutritional status of cancer patients and to provide scientific basis for further nutritional intervent... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：癌症患者维生素D营养状况分析】 【中文摘要：背景与目的 维生素营养状况与癌症患者之间存在一定的关联，已有研究表明缺乏维生素会增加罹患癌症的风险，本研究的目的是了解癌症患者的维生素D营养状况，为进一步实施营养干预提供科学依据。方法 本研究回顾性分析了2017年7月-2019年6月在山东省肿瘤医院就诊的癌症患者血清25-羟维生素D的水平，采用SPSS 20.0统计软件进行单因素分析和多元线性回归分析。结果 本研究共纳入2,487例癌症患者，平均血清25-羟维生素D的浓度为（12.70±6.82）ng/mL，纳入的癌症患者中维生素D缺乏者[25（OH）D<20.00 ng/mL]占比92.20%。单因素分析显示：年龄、身体质量... | zh-cn |
pair_34034459 | Studies have shown that elevated serum lactate dehydrogenase (LDH) concentration can lead to poor prognosis in patients with small cell lung cancer and lung adenocarcinoma, but its relationship with the prognosis of patients with lung large-cell neuroendocrine carcinoma (L-LCNEC) is not clear. This study aims to explor... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：手术前后血清LDH浓度与大细胞神经内分泌
肺癌患者手术预后的相关性分析】 【中文摘要：背景与目的 血清乳酸脱氢酶（lactate dehydrogenase, LDH）浓度升高，会导致小细胞肺癌、肺腺癌患者预后不佳，但其与大细胞神经内分泌肺癌（lung large-cell neuroendocrine carcinoma, L-LCNEC）患者预后的关系并不清楚，本研究旨在探讨L-LCNEC患者术前血清LDH浓度、术后LDH浓度变化趋势对患者术后无病生存期（disease-free survival, DFS）的影响，从而为判断L-LCNEC的临床预后提供新的思路。方法 本研究共纳入49例L-LCNEC术后患者，通过医... | zh-cn |
pair_34034460 | Treatments for advanced non-small cell lung cancer (NSCLC) include chemotherapy, targeted therapy, and immunotherapy represented by immune checkpoint inhibitors. However, the efficacy of monotherapy is still limited. Nowdays, combination strategy has drawn great attention. Anti-angiogenic agents are widely used in trea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：晚期非小细胞肺癌抗血管生成药物的
联合治疗模式】 【中文摘要：晚期非小细胞肺癌的治疗方案包括化疗、针对驱动基因的靶向治疗以及以免疫检查点抑制剂为代表的免疫治疗，疗效仍待进一步提高，而联合治疗是当前研究热点。抗血管生成药物在晚期非小细胞肺癌中应用广泛，不仅能通过抑制肿瘤新生血管来抑制肿瘤的生长和转移，还能使血管正常化，调节肿瘤微环境，从而与其他抗肿瘤治疗方式协同增效，共同抑制肿瘤生长。这篇文章通过分析抗血管生成治疗与其他抗肿瘤治疗联合应用的机制，回顾关于大分子单克隆抗体、小分子抗血管生成靶向药物联合其他抗肿瘤方案的临床研究，汇总其疗效及安全性，为晚期非小细胞肺癌的治疗策略提供新的角度和思路。
】 【中文关键词：肺肿瘤；抗血... | zh-cn |
pair_34034462 | The echinoderm microtubule associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) were fractured and fused to become EML4-ALK. Most of these EML4-ALK-positive non-small cell lung cancer patients respond well to the ALK inhibitor. Many patients can benefit from drug target therapy for a long time, and som... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：经3种ALK抑制剂及化疗治疗的
1例非小细胞肺癌病例报道】 【中文摘要：棘皮动物微管相关蛋白4（echinoderm microlubule-associated protein-like 4, EML4）和间变淋巴瘤激酶基因（anaplastic lymphoma kinase, ALK）可发生断裂后融合为EML4-ALK基因。对于EML4-ALK阳性非小细胞肺癌（non-small cell lung cancer, NSCLC），一代至三代的ALK抑制剂的使用已显示出显著疗效，很多患者可以从药物治疗中实现长期获益，部分患者在优化的治疗模式下可取得超过7年的长期生存。本例患者为EML4-ALK融合基因阳性肺腺癌，治疗... | zh-cn |
pair_34034468 | Hormone receptor (HR), human epidermal growth factor receptor-2(HER-2) double positive breast cancer is a highly aggressive disease, and it is more susceptible to drug resistance and metastasis. Currently, although anti-HER-2 monoclonal antibody combined with endocrine therapy is commonly used in clinical practice, pat... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 激素受体(HR)阳性人表皮生长因子受体2(HER-2)阳性乳腺癌侵袭性强，易发生耐药而复发转移，目前临床多采用抗HER-2单抗联合内分泌治疗。但即使两药联合治疗，患者的预后仍不理想，这可能是HER-2下游的PI3K/Akt/mTOR信号通路激活所导致，因此HER-2受体胞外、胞内及其下游PI3K/Akt/mTOR信号通路多重抑制，及HER-2和HR的双重阻断，更有利于HR阳性HER-2阳性乳腺癌的治疗。小分子酪氨酸激酶抑制剂奈拉替尼不仅能抑制HER-1、HER-2和HER-4受体磷酸化，还可以阻断PI3K/Akt和Ras/Raf/MEK/ERK途径的下游信号传导。在强化辅助治疗研究中已证实，奈拉替尼可改善HER-2阳性乳腺癌患者的预... | zh-cn |
pair_34034469 | Osteosarcoma is a kind of primary malignant tumor of bone originated from mesenchymal tissue, which mainly occurs in children and adolescents, and presents the characteristics of high malignancy, rapid growth, early metastasis and poor prognosis. Currently, most of the studies at home and abroad mainly focused on thera... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 骨肉瘤是间叶组织起源的原发性骨恶性肿瘤，主要发生于儿童和青少年，具有恶性程度高、生长迅速、早期转移、预后较差等特点。当前，国内外的研究方向均主要集中在治疗上，但可靠的预测指标或评价系统对监测病情变化、指导治疗和预后评估等也非常重要。与骨肉瘤预后相关的临床预测指标较多，根据其特点可大致分为9大类，每类指标均有其优点和不足。充分认识和了解这些指标的特点，有针对性地选择应用，将有助于改善骨肉瘤的预后。. | zh-cn |
pair_34035489 | Intraocular liquids tamponade agents, such as perfluorocarbon liquids (PFCLs), semifluorinated alkanes (SFAs), silicone oils (SOs) and heavy silicone oils (HSOs), are a crucial intraoperative and/or postoperative tool in vitreoretinal surgery, in particular for the management of complex vitreoretinal diseases. However,... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 摘要: 眼内液体填充剂, 如全氟化碳液体 (PFCLs) 、半氟化烷烃 (SFAs) 、硅油 (SOs) 和重硅油 (HSOs), 是玻璃体视网膜手术中及术后重要的玻璃体填充物, 对于复杂的玻璃体视网膜疾病的治疗尤其重要。然而, 这些填充剂可产生甚至严重的并发症。因此, 人们越来越关注这些化合物的生物相容性以及现行法规是否足以保证其使用的安全性。显然, 不仅对玻璃体视网膜疾病的外科医生来说, 或是对任何参与眼内液体填充患者治疗的眼科医生来说, 对眼内液体填充剂的研究结果和潜在风险有最新的认识和了解是必不可少的。有鉴于此, 本文就眼内液体填充剂的理化性质、临床应用现状及可能产生的并发症作一综述。此外, 本文还对这些填充剂的安全性进行了... | zh-cn |
pair_34037992 | The working alliance has been shown to be a robust predictor of couple therapy outcomes. However, there are still questions regarding the best way to conceptualize and analyze the association between the alliance and outcomes in the couple therapy context. This study presents results from a relatively novel analytic ap... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 关系联盟可以比较准确地预测伴侣治疗的结果，这都是已经被证实过了的。然而，在伴侣治疗的背景下，如何理解和分析这种联盟与治疗结果之间的关系，依然还存在问题。本研究采用了一种相对新颖的分析方法，通过共享影响模型 (即共同命运统计方法)来评估联盟和治疗结果。研究对象为93对至少参加过三次治疗会谈的伴侣。通过这种方式来考察伴侣治疗中的联盟，可以认识更多伴侣和伴侣治疗师之间的联盟过程中出现的细微差别。在实证经验上，仍然存在的问题是伴侣共同经历的联盟关系是否会比独特的个人单方面体验的联盟关系更能预测治疗结果。这种方法还没有被使用在建立伴侣联盟-结果的关系模型中去。研究结果显示，共同影响模型能展现联盟与治疗结果之间的显著关联。具体而言，从伴侣与治疗... | zh-cn |
pair_34037992 | The working alliance has been shown to be a robust predictor of couple therapy outcomes. However, there are still questions regarding the best way to conceptualize and analyze the association between the alliance and outcomes in the couple therapy context. This study presents results from a relatively novel analytic ap... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Se ha demostrado que la alianza terapéutica es un predictor fiable de los resultados de la terapia de pareja. Sin embargo, aún quedan preguntas con respecto a la mejor manera de conceptualizar y analizar la asociación entre la alianza y los resultados en el contexto de la terapia de pareja. Este estudio presenta result... | es |
pair_34038576 | John Weir Perry's influence on the understanding of the psychotic process through his research in San Francisco between 1950 and 1981 was groundbreaking, because it both verified and expanded upon C.G. Jung's research at the Burghölzli Hospital in Switzerland in the early 1900's. The author explores both the brilliance... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’influenza di John Weir Perry sulla comprensione dei processi psicotici con le sue ricerche a San Francisco tra il 1950 ed il 1981 fu rivoluzionaria, perchè verificava e sviluppava le ricerche di Jung al Burghölzli ai primi del ‘900. L’Autrice esplora l’originalità del contributo di Perry come psichiatra e come analis... | it |
pair_34038576 | John Weir Perry's influence on the understanding of the psychotic process through his research in San Francisco between 1950 and 1981 was groundbreaking, because it both verified and expanded upon C.G. Jung's research at the Burghölzli Hospital in Switzerland in the early 1900's. The author explores both the brilliance... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 对J.W. Perry, M.D的个人评论, 以及对“自性的心理病理学中的重构过程”的介绍 John Weir Perry对于精神疾病过程的理解具有开创性对影响, 这来自于其1950-1981年间在旧金山的研究。其影响具有开创性, 是因为它是荣格在瑞士Burghölzli 医院1900年早期研究的论证与发展。作者探索了Perry作为精神科医生和荣格分析师所做出的了不起的贡献, 同时也展现了一个有瑕疵的人类, 他具有罕见的敏感性, 也有经历了精神病的历程, 把一生的工作奉献给了精神分裂症的群体, 以及他们对于意义的不幸探寻。文章呈现了他如何创造性地投入到自性发现的分析性历程, 及最终导致他违反了分析的边界, 最后, 他因此被当地荣格社... | zh-cn |
pair_34038576 | John Weir Perry's influence on the understanding of the psychotic process through his research in San Francisco between 1950 and 1981 was groundbreaking, because it both verified and expanded upon C.G. Jung's research at the Burghölzli Hospital in Switzerland in the early 1900's. The author explores both the brilliance... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’influence de John Weir Perry sur la compréhension du processus psychotique à travers ses recherches à San Francisco entre 1950 et 1981 fut considérable. Elle confirma et élargit les recherches de C.G. Jung au Burghölzli en Suisse au début du XXème siècle. L’auteur explore d’une part l’intelligence de la contribution ... | fr |
pair_34038576 | John Weir Perry's influence on the understanding of the psychotic process through his research in San Francisco between 1950 and 1981 was groundbreaking, because it both verified and expanded upon C.G. Jung's research at the Burghölzli Hospital in Switzerland in the early 1900's. The author explores both the brilliance... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | John Weir Perrys Einfluß auf das Verständnis des psychotischen Prozesses durch seine Forschungen in San Francisco zwischen 1950 und 1981 war bahnbrechend, da er C.G. Jungs Forschung der Klinik Burghölzli in der Schweiz Anfang des 20. Jahrhunderts sowohl verifizierte als auch erweiterte. Die Autorin untersucht sowohl di... | de |
pair_34038576 | John Weir Perry's influence on the understanding of the psychotic process through his research in San Francisco between 1950 and 1981 was groundbreaking, because it both verified and expanded upon C.G. Jung's research at the Burghölzli Hospital in Switzerland in the early 1900's. The author explores both the brilliance... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La influencia de John Weir Perry a la comprensión de los procesos psicóticos a través de su investigación en San Francisco entre 1950 y 1981 fue pionera, al verificar y expandir las investigaciones de C.G. Jung en el Hospital Bürgholzli, en Suiza a comienzos de l900. La autora explora tanto la brillantez de las contrib... | es |
pair_34038576 | John Weir Perry's influence on the understanding of the psychotic process through his research in San Francisco between 1950 and 1981 was groundbreaking, because it both verified and expanded upon C.G. Jung's research at the Burghölzli Hospital in Switzerland in the early 1900's. The author explores both the brilliance... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Новаторские идеи Джона Виира Перри и его вклад в понимание психотического процесса, которого он достиг в ходе своих исследований, проведенных с 1950 по 1981 года в Сан Франциско, имел колоссальное значение, потому что они подтверждали и расширяли исследования К.Г. Юнга в клинике Бургольци в начале 1900 годов. Автор ста... | ru |
pair_34038577 | This paper is based on one idea and built around one clinical experience that helped me to broaden my comprehension of it. The idea, underlying the work of several authors, is that when the analytic field is saturated with primitive and unintegrated mental contents, the analyst's somatic countertransference is a precio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Questo articolo si fonda su di un’unica idea, e si sviluppa attorno ad un’unica esperienza clinica che mi ha aiutato ad allargarne la comprensione. L’idea, alla base del lavoro di diversi autori, è che quando il campo analitico è saturo di contenuti mentali primitivi non integrati, il controtransfert somatico dell’anal... | it |
pair_34038577 | This paper is based on one idea and built around one clinical experience that helped me to broaden my comprehension of it. The idea, underlying the work of several authors, is that when the analytic field is saturated with primitive and unintegrated mental contents, the analyst's somatic countertransference is a precio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 钟表停下的那一天:未整合的原始状态, 多层次的修通以及分析性主体的诞生 这篇文章是基于我围绕一个观念获得的临床经验, 这个经验又帮助我进一步理解了这个观念。这个构成许多作者工作基础的观念是:当分析的场域被原始和未整合的心理内容浸染之时, 分析师身体层面的反移情就成为了珍贵的指标, 带来深层的、分裂形式的沟通。这个临床经验涉及对一个情结困难的精细描绘, 关系到在分析早期阶段多层面的反移情, 期间我面对了一位敏感的, 以让我难以承载的非常分裂的方式进行沟通的来访者。文中详细描述了这一经验, 它让我形成了一个临床的观点:移情场域由多个不同的层面构成 (精神的, 情绪的, 语言的), 而每一层都可能包含分裂的, 甚至相对立的信息。其必然的结... | zh-cn |
pair_34038577 | This paper is based on one idea and built around one clinical experience that helped me to broaden my comprehension of it. The idea, underlying the work of several authors, is that when the analytic field is saturated with primitive and unintegrated mental contents, the analyst's somatic countertransference is a precio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Cet article est fondé sur une idée et construit autour de l’expérience clinique qui m’a aidé à en élargir la compréhension. Cette idée - qui sous-tend le travail de plusieurs auteurs - est la suivante: quand le champ analytique est saturé de contenus mentaux primitifs et non-intégrés, le contretransfert somatique de l’... | fr |
pair_34038577 | This paper is based on one idea and built around one clinical experience that helped me to broaden my comprehension of it. The idea, underlying the work of several authors, is that when the analytic field is saturated with primitive and unintegrated mental contents, the analyst's somatic countertransference is a precio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Dieser Beitrag basiert auf einer speziellen Idee und baut auf einer klinischen Erfahrung auf die mir geholfen hat, mein Verständnis zu erweitern. Diese Idee, die der Arbeit mehrerer Autoren zugrunde liegt, besteht darin, daß, wenn das analytische Feld mit primitiven und nicht integrierten mentalen Inhalten gesättigt is... | de |
pair_34038577 | This paper is based on one idea and built around one clinical experience that helped me to broaden my comprehension of it. The idea, underlying the work of several authors, is that when the analytic field is saturated with primitive and unintegrated mental contents, the analyst's somatic countertransference is a precio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El presente trabajo se basa en una idea y se construye en base a una experiencia clínica que me ayudó a ampliar mi comprensión sobre la misma. La idea, que subyace al trabajo de varios autores, es que cuando el campo analítico está saturado con contenidos mentales primitivos y no integrados, la contratransferencia somá... | es |
pair_34038577 | This paper is based on one idea and built around one clinical experience that helped me to broaden my comprehension of it. The idea, underlying the work of several authors, is that when the analytic field is saturated with primitive and unintegrated mental contents, the analyst's somatic countertransference is a precio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Эта статья основана на идее и клиническом опыте, который расширил мое понимание. Идея, лежащая в основе работы нескольких авторов, заключается в следующем: когда аналитическое поле насыщено примитивными и неинтегрированными психическими содержаниями, то соматический контрперенос аналитика является драгоценным показател... | ru |
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