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pair_28956396 | Biofilms are surface-associated communities of microorganisms embedded within self-secreted extracellular polymeric substances, and a major cause of chronic and persistent infections. Respiratory Pseudomona aeruginosa infection is the leading reason for morbidity and mortality in cystic fibrosis patients. The formation... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 生物被膜是单细胞微生物通过其分泌的胞外多聚基质粘附于介质表面并将其自身包绕其中而成的膜样微生物细胞聚集物。生物被膜的形成使细菌具有更强的适应外界环境的能力,也是导致微生物产生耐药性及慢性感染性疾病难以治疗的重要原因之一。铜绿假单胞菌在肺部的定殖是肺囊性纤维化病患者发病和死亡主要原因,其造成的感染通常与形成抗生素抗性极强的生物被膜有关。铜绿假单胞菌生物被膜的形成受控于多种复杂的细菌调控体系之下,包括群体感应系统及参与调节胞外多聚基质合成的双组分调控系统等。此外,为了利用低浓度的环境铁来维持生存并完成各种生理功能,铜绿假单胞菌进化出了一系列铁摄取系统,这些系统对其毒力因子的释放和生物被膜的形成又起着重要的调控作用。本文主要对铜绿假单胞菌... | zh-cn |
pair_28956399 | Biofilm associated Vibrio cholerae exhibits hypervirulence and supreme fitness against the harsh stresses during its infectious cycle. It is important to study the relationships between the regulation mechanism of V. cholerae biofilm development and its environmental adaption in host niche and aquatic habitat. Here, we... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 生物被膜状态的霍乱弧菌具有极强的环境适应性和超高的感染性,生物被膜的发育调控研究对霍乱弧菌的宿主感染和环境适应非常重要。本文综述了近年来霍乱弧菌生物被膜研究结果,包括霍乱弧菌生物被膜的组成、发育和环境调控,尤其着重阐述了各种环境因子对霍乱弧菌生物被膜发育的影响,包括细菌自体信号分子、自然环境因子和宿主信号分子。. | zh-cn |
pair_28956400 | Dental biofilms are composed of hundreds of bacterial species, among which Streptococcus mutans is widely recognized as the major pathogen of dental caries. The cariogenic potential of S. mutans is related to its ability to form a robust biofilm on the tooth surface and its acidogenic and acid-tolerant properties. Co-e... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 口腔生物被膜是由数百种微生物构成的复杂微生物群体。变形链球菌作为其中的重要一员,被认为是引起龋病的主要病原菌。变形链球菌在牙齿表面以生物被膜形式生长的能力和它产酸耐酸的特点赋予其致龋性。不同的变形链球菌菌株之间保留了多样的次级代谢形式,这是与宿主长期共进化的结果。迄今为止,变形链球菌中报道的次级代谢产物包括10 种细菌素 (又称变链素) 和一种聚酮/非核糖体肽类化合物。这些化合物多样的活性形式暗示了它们参与口腔生物被膜中跨种间和跨界间的相互作用。未来随着变形链球菌菌株数目的增加和更多菌株全基因组序列的完成,可以预见会有更多新颖活性次级代谢产物的出现。对变形链球菌次级代谢的研究不仅有助于治疗和预防口腔疾病,而且新颖活性次级代谢产物的发... | zh-cn |
pair_28956401 | Fungal pathogens represent an important group of human pathogenic microbes that lead to an unacceptably severe global burden especially due to exceptionally high mortality. For many fungal pathogens, they are widespread saprophytes and human host is not the exclusive niche for their proliferation. Their exceptional cap... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 人类病原真菌代表了病原微生物一个重要类群,主要感染免疫缺陷、受损和受抑制的患者,导致很高的死亡率。绝大多数的人类病原真菌属于环境病原微生物,它们与人类宿主并无长期共同进化史以及紧密的共生关系,这类真菌被称为环境病原真菌。新生隐球菌作为环境病原真菌的模式种,每年导致约60 万人死亡。与其他环境病原真菌相似,该菌的致病能力并不由宿主因素驱动,而是衍生于其对于生境压力出色的适应性策略。近几年来的研究表明,群体或社会行为可能作为一个关键环境适应策略,广泛参与新生隐球菌的感染、耐药以及有性生殖过程。本文以新生隐球菌为例,针对生物被膜以及生物被膜样群落,总结其中的群体或社会调控方式,并对其研究前景和临床应用提出了一些思考。. | zh-cn |
pair_28956403 | Myxococcus xanthus is a Gram-negative soil bacterium capable of performing sophisticated cellular behaviors and growing one of the most intricate bacterial single-species biofilms in nature. During the process of biofilm formation, social behaviors of M. xanthus cells dominate key steps of the biofilm establishment, e.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 黄色粘球菌具有多样化的细胞行为,具备典型多细胞水平的社会性特征。其形成的生物被膜是目前认知的最为复杂的单种群细菌生物被膜之一。黄色粘球菌的社会性细胞行为主导了其生物被膜形成过程中的关键环节,包括固体介质表面的细胞运动、群体细胞的捕食、亲缘细胞的识别、子实体的发育、粘孢子的分化以及细胞程序性死亡等行为过程。文中将介绍相关领域的研究进展。. | zh-cn |
pair_28956405 | Twitching motility is very important for Pseudomonas aeruginosa in the adaptation of surface environment and in the 3-D structure formation of mature biofilm. To quantitatively characterize twitching motility in situ, we developed a method by combining high-throughput data acquisition, automatic image processing and da... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 蹭行运动在生物被膜形成过程中对细菌适应表面环境以及后续生物被膜三维结构的形成起重要作用。因此,对蹭行运动的原位表征、量化是生物被膜研究中的重要科学问题之一。我们通过高通量数据采集、自动化图像处理、数据库建立以及图形化输出等技术手段,建立了一整套基于单细菌的统计分析方法。利用这一方法对蹭行运动中的行走、弹射过程进行了详细分析,发现弹射运动过程中存在以0.9 s 为周期的周期性弛豫。并定量比较了群体感知信号分子对蹭行运动的影响,发现加入信号分子后蹭行运动在高速区明显增强。该方法的建立为后续蹭行运动分子机制以及调节方式的研究奠定了基础。. | zh-cn |
pair_28956406 | Quorum sensing (QS) is a cell-cell communication mechanism that allows bacterial populations to coordinate gene expression in response to cell density. N-acylhomoserine lactones (AHL) are used as quorum-sensing signal molecules by many Gram negative bacteria. Acinetobacter sp. 77, an AHL-degrading bacterium, was isolat... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 群体感应 (Quorum sensing,QS) 是细菌在进化过程中形成的依赖于群体密度的细菌间交流方式。许多革兰氏阴性细菌以N-酰基高丝氨酸内酯 (AHL) 为信号分子,感应自身群体密度并调控致病基因表达。因此,淬灭AHLs 信号分子可防治此类细菌引起的植物病害。本实验室前期已筛选得到了一株具有AHLs 信号降解能力的不动杆菌菌株Acinetobacter sp. 77,本研究通过基因组文库筛选,自菌株77 中克隆得到具有AHLs 降解活性的基因aidE。该基因编码268 个氨基酸。序列一致性比较发现aidE 的氨基酸序列与吉伦伯不动杆菌Acinetobacter gyllenbergii CIP110306 中β-内酰胺酶一致性... | zh-cn |
pair_25516308 | Asian regions have been suffering from growing double burden of nutritional health problems, such as undernutrition and chronic diseases. National nutrition survey plays an essential role in helping to improve both national and global health and reduce health disparities. The aim of this review was to compile and prese... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 亚洲地区现在正出现双重营养健康问题,比如营养不良和慢性疾病。全国营养 普查在帮助提高国家和全球健康水平和减少健康不平等至关重要的作用。本综 述的目的是整理和呈现当前亚洲各个国家中全国营养普查信息,并对全国营养 普查出现的一些问题提出建议。亚洲有15 个国家开展了全国性的营养普查来收 集人群营养健康状况资料。每个国家营养普查的资料来源于政府文件、国际组 织、政府机构的调查网站、一些出版物,包括发表在期刊的文章、书籍、报道 以及一些小册子等。各个国家营养普查有其不同变量和程序。普查的变量包 括,社会人口和生活方式、食物和饮料、饮食习惯和个人或家庭的食品保障; 还有一些健康指标方面的变量,比如人体测量指标和生化指标。调查主要侧重 于收集5... | zh-cn |
pair_25516309 | Cambodia is among the 28 worst countries globally with the highest rates of childhood malnutrition. The aim of the assessment was to apply published evidence associating malnutrition and a variety of functional consequences to project economic implications of this high rate of childhood malnutrition. Such information i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景:柬埔寨是全球28 个儿童营养不良发生率最高的国家之一。本文的目的 是运用已发表的营养不良相关的证据及对各种功能的影响,来评估儿童营养不 良高发率的经济影响。这些信息对提出合适的方案和行动计划来降低营养不良 (从严重的发育迟缓到微量营养素缺乏)是至关重要的。方法:本研究用全 球科学文献中关于柬埔寨人的健康、人口和文化的数据,使用“结果模型”,应 用“损失系数”以评估国家与营养不良相关的经济损失。结果:据估计因营养不 良指标的影响,柬埔寨国家经济负担每年增加4 亿美元以上,约占国家GDP 的2.5%。微量营养素缺乏表明膳食质量差,每年给国家造成超过2 亿的负 担,其中母乳喂养行为占6%。57%的损失来自儿童测量指标,其他43%的损... | zh-cn |
pair_25516310 | Elderly Greek-born Australians (GA) consistently show lower rates of all-cause and CVD mortality compared with Australian-born. Paradoxically, however, this is in spite of a higher prevalence of CVD risk factors. This paper reviews the findings from the Food Habits in Later Life (FHILL) study, other studies on Greek mi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 与澳大利亚出生的老年人相比,希腊出生的澳大利亚老人全死因死亡率和心血 管疾病死亡率一直都较低,然而,这与其心血管疾病风险因子的高发率相矛 盾。本文综述了希腊人移民到澳大利亚后生活饮食习惯对后期生命的研究,其 研究结果可能能够用膳食机制解释临床研究的“发病率死亡率悖论”。本课题收 集了1988-1991 年之间关于生活饮食习惯对后期生命的研究,包括来自瑞典、 希腊、澳大利亚(希腊人和盎格鲁- 凯尔特人)、日本的818 名70 岁及其以上 老人饮食、健康和社会心理等参数资料,随访5-7 年以确定其生存状态。该研 究首次形成以得分来获得以传统植物为基础的地中海膳食模式的主要特征。较 高的得分能够提高希腊老人和非希腊老人总的生存率,并使其5... | zh-cn |
pair_25516311 | This work represents the first part of a progressive review of AuSPEN's 1999 Guidelines for Provision of Micronutrient Supplementation in Adult Patients receiving Parenteral Nutrition, in recognition of the developments in the literature on this topic since that time. A systematic literature review was undertaken and r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景:这项工作代表了澳大利亚肠内肠外营养学会自1999 年出台《对接受肠 道外营养的成年患者微量元素补充指南》以来对该领域进展的认可按文献进行 逐步综述的第一部分。方法:通过系统文献综述,基于现有证据并考虑对澳大 利亚和新西兰执业环境的具体内容提出建议。对每项建议的证据力度进行评 估。外部评审人员通过AGREE II 针对指南提供反馈。结果:相比于1999 年 的指南,建议减少锰、铜、铬和钼的剂量,增加硒的剂量。目前市面上多元微 量元素配方的成分是公认的指南实践中的障碍。现有文献的缺乏及监测微量元 素状况的方法存在局限性,使用的肠外营养中微量元素污染对临床的影响不清 楚,需要进一步研究及临床实践。结论:接受肠外营养的患者需要每天补充... | zh-cn |
pair_25516313 | It is important to identify patients who are at risk of malnutrition upon hospital admission as malnutrition results in poor outcomes such as longer length of hospital stay, readmission, hospitalisation cost and mortality. The aim of this study was to determine the prognostic validity of 3-Minute Nutrition Screening (3... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 营养不良会导致住院时间延长、再入院、住院费用增加和死亡率增加等不良预 后,因此确定住院患者是否存在营养不良风险很重要。本研究的目的是通过诊 断相关组列表(DRG)确定三分钟营养筛查(3-MinNS)在预测三级医院急性 住院患者临床结果的预后有效性。在这项研究中,有818 名成年患者在入院 24 小时内用3-MinNS 筛查了其营养不良风险。从国家登记的包括其它住院治 疗结果的医院电子档案中获得死亡率数据。结果校正了年龄、性别和种族,并 以诊断相关组进行匹配。用3-MinNS 确定的有营养不良风险的患者占37%, 与营养不良呈显著正相关的有:较长的住院时间(6.6±7.1 天 vs 4.5±5.5 天, p<0.001)、较高的住院费... | zh-cn |
pair_25516314 | Many studies have demonstrated the efficacy of folic acid (FA) supplementation in prevention of neural tube defects (NTDs), although the extent of NTDs varies among individuals of different races and ethnic origin. China is a multi-ethnic country with no standard practice for FA-fortified food. Milk is consumed by wome... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 许多研究证明补充叶酸能够有效预防神经管畸形,然而不同种族间神经管畸形 的发生程度不同。中国是一个没有实施叶酸强化标准食物的多民族国家,尚不 清楚补充牛奶是否对中国汉族和蒙古族怀孕妇女停止服用叶酸1 个月和5 个月 后的血清和脐带血中叶酸含量有影响。本研究的目的是确定怀孕妇女停止服用 叶酸后,每天补充液体牛奶是否能够增加血液中叶酸的含量,以及汉族和蒙古 族之间是否有差别?4052 名妇女参与了此项研究,其中3526 名妇女被确认怀 孕,随机分为补充牛奶组和不补充牛奶组。结果显示补充牛奶后,无论汉族还 是蒙古族,在孕16 周和32 周及脐带血中的叶酸含量都显著升高。补充牛奶的 妇女所生婴儿的体重和身高都好于未补充牛奶妇女所生的婴儿,这可... | zh-cn |
pair_25516315 | Probiotics are microbial supplements that have shown efficacy in a wide range of applications. To assess the safety and effects of enteral probiotics in critically ill neonates. A double-blind, randomized controlled trial was conducted in 100 full-term infants with critical illness according to scores of neonatal acute... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:益生菌作为微生态调节剂应用广泛而且效果显著,本研究的目的是为了 探讨益生菌治疗危重新生儿的有效性及安全性。方法:根据急性新生儿生理 学评分选取100 名危重足月新生儿进行双盲、随机对照试验。 随机给予50 名 新生儿口服益生菌治疗,每天三次,连续8 天,另外50 名新生儿则给予安慰 剂。记录败血症、多器官功能障碍综合征、院内获得性肺炎及坏死性小肠结肠 炎的发病率,疾病好转率及住院时间,并分别在治疗后第4 天及第8 天测定患 儿血浆中IgA、IgG 和IgM 的浓度。结果:治疗组患儿医院获得性肺炎(18% 比36% ) 和多器官功能障碍综合征( 6% 比16% ) 显著低于安慰剂组 (p<0.05),住院时间(13±3.5 天比... | zh-cn |
pair_25516318 | To assess the difference between early enteral nutrition (EEN group) and total parenteral nutrition (TPN group) after total gastrectomy for gastric cancer. The nutrition index, liver function, patient generated subjective global assessment (PG-SGA) score, the post-operation complications, the hospital stay and hospital... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:评价胃癌患者全胃切除术后,早期肠内营养(EEN)与全肠外营养 (TPN)的差异。方法:收集2011 年5 月至2013 年5 月我科收治的胃癌全胃 切除患者,术后随机选择EEN 或TPN,对EEN 组和TPN 组患者术前及术后 的营养指标、肝功能、癌症患者营养评估标准(PG-SGA)、术后并发症、住 院时间以及住院费用进行对照研究。结果:符合入选标准的胃癌全胃切除患 者共72 例,其中EEN 组37 例,TPN 组35 例。EEN 组在术后3~5 天低白蛋 白血症逐渐改善,而TPN 组术后21 天才逐渐恢复。EEN 组术后14 天体重较 术前减轻,术后21 天逐渐恢复,而TPN 组在术后21 天内体重无明显恢复 (p<0.05... | zh-cn |
pair_25516319 | We aimed to prospectively assess dairy intake among adolescents, and determine the predictors of adequate dairy consumption during adolescence. 634 Sydney schoolchildren (351 girls and 283 boys) who had dietary data at both age 12 and 17 were included for analyses. Dairy consumption was assessed from validated semi-qua... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 我们前瞻性测量青少年每日摄入量,从而预测他们的日消耗量。有膳食数据的 634 位年龄在12-17 岁悉尼在校学生(351 个女孩,283 个男孩)包括在最后分 析里。乳品摄入量是用验证的半定量食物频率问卷评估的。12 岁青少年的乳品 摄入量是1.62 份/天,而到17 岁,则降为1.40 份/天(p<0.05)。青少年的日 均牛奶的摄入量从1.11 降至0.92。而且,90%的每日摄入乳品份数的下降量是 有牛奶的摄入减少引起的。12 岁时,有8.5%的儿童乳品摄入大于3.5 份/天,5 年之后,即17 岁时,降为6.2%(p=0.001)。无论是12 岁还是17 岁,女孩乳 品摄入>=3 份/天的比例都少于于男孩(p=0.005 和... | zh-cn |
pair_25516320 | Clinical practice guidelines recommend objective nutritional assessments in managing chronic kidney disease (CKD) patients but were developed while referencing to a North-American population. Specific recommendations for assessing muscle mass were suggested (mid-arm circumference, MAC; corrected mid-arm muscle area, cA... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景:在慢性肾脏病患者的管理中,临床实践指南推荐的客观营养评估是参 考北美人群开发的。具体的肌肉质量评估建议如下:中臂围(MAC)、校正 的中臂肌肉面积(cAMA)和中臂肌围(MAMC)。本研究的目的是在多民族 亚裔人群中评估健康人和慢性肾脏病患者肌肉质量与膳食蛋白质摄入量之间的 关系。方法:我们分析了所收集的参与者24 小时尿来估算总蛋白质摄入量 (TPI,克/天)。计算理想体重(IDW,千克)并评估肌肉。应用相关性和线 性回归分析,显著性定义为p<0.05。结果:共有232 名稳定的慢性肾脏病患 者和103 名健康志愿者参加,其平均年龄为53.5±15.1 岁, 51.0%为男性,其 中华人占38.5%、马来人占29.6%、印度... | zh-cn |
pair_25516321 | Iodine content in table salt was adjusted from 30-50 mg/kg to 21-39 mg/kg from March of 2012 in Henan Province, China. The vulnerable population may be at risk of iodine deficiency. To determine whether the iodine intake was sufficient in vulnerable populations and to investigate what factors may be associated with iod... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景:从2012 年3 月起,中国河南省食盐中碘浓度从30-50 mg/kg 调整到21- 39 mg/kg。由于食盐中碘浓度的下调,重点人群可能有碘缺乏的风险。目的: 了解河南省重点人群的碘营养状况是否适宜,并探索与碘营养相关的影响因 素。方法:从2012 年4 月至2012 年12 月,在中国河南省的17 个城市对重点 人群的碘营养状况开展横断面调查,包括育龄妇女2648 名、孕妇39684 名、 哺乳期妇女6859 名、0-2 岁婴幼儿16481 名和8-10 岁儿童3198 名。通过问卷 形式收集调查对象的人口学因素和膳食情况,共收集问卷4865 份。结果: 2012 年河南省育龄妇女、孕妇、哺乳期妇女、0-2 岁婴幼儿和8... | zh-cn |
pair_25516322 | The WHO recommends exclusive breastfeeding during the first 6 mo of life; however, deviations from this recommendation are widespread. The objective of the current study was to evaluate exclusive and predominant breastfeeding rates, as defined by the WHO, in a cross-sectional sample of Guatemalan children using retrosp... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 世界卫生组织(WHO)建议在出生后的6 月内进行纯母乳喂养,然而经常很 多人无法做到这一点。本研究对危地马拉儿童采用横断面研究,使用回顾记录 的时间模式,了解6 月龄之前婴儿的食物及饮料情况,根据WHO 规定的喂养 标准,来评估纯母乳喂养率以及以母乳为主的喂养率。150 名6-23 月龄的孩子 的母亲在公共卫生诊所接受了婴儿早期生活的结构问卷调查。此外,报道了自 出生以来以及目前除母乳外的为孩子提供的液体和食物的合理性。我们发现, 纯母乳喂养的情况很少,估计只有14%的婴儿接受5 个月的纯母乳喂养,只有 9%的婴儿纯母乳喂养能到达推荐的6 个月。以母乳为主,同时给予液体比如 水、果汁、仪式液体等喂养5 个月的占33%,喂养6 个月的... | zh-cn |
pair_25516323 | Childhood obesity is tracked to adulthood at a high rate. However, longitudinal studies of obesity in early childhood remain limited. This study aimed at tracking young obese children back to birth in comparison with normal-weight children, and investigating the relationship with parental obesity. A total of 2,678 (1,3... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:肥胖从儿童期持续到成年期的比例很高,然而,关于幼儿肥胖的纵向 研究仍然有限。本研究旨在与正常体重儿童相比,追踪肥胖幼儿到出生,并研 究其与父母肥胖的关系。方法:本研究纳入了日本奈良地区的学前班或幼儿 园的2,678 名(男孩1,353 名)幼儿。通过问卷获得了儿童和父母目前的身高 和体重,通过母子的健康笔记本所记录的资料获得儿童出生、1.5 岁和3.5 岁 时的身高和体重。分别用体质指数(BMI)大于或等于日本儿童参考数据的 90th 和25(kg/m²)作为儿童和父母肥胖的判断标准。结果:儿童总的肥胖患 病率从出生时的10.2%下降到5 岁时的5.6%。在回顾性追踪中,5 岁时肥胖的 儿童体重的Z 值和BMI 的百分位值从出... | zh-cn |
pair_25516325 | The association between water and nutrient intake in pregnant women, and wheeze in their 18 month old infants, was investigated in a prospective study. Volunteers (n=369) recruited from northern New Zealand were visited in months 4 and 7 of pregnancy. At each visit anthropometric measurements were taken, diet assessed ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 本研究为一项前瞻性研究,调查妇女孕期水和营养素的摄入与他们18 个月大 的婴儿哮鸣音之间的关系。从新西兰北部招募怀孕4 到7 个月的志愿者369 名。每次随访检测其志愿者的人体测量参数,采用24 小时回顾法和3 天的膳 食记录进行饮食评估,采用问卷调查确定入选者的个人资料。婴儿出生后18 个月,检查并询问其喂养和哮鸣音情况。总体而言,据母亲报告,在过去的 12 个月里,她们的婴儿中有32%的出现过气喘。校正重要的协变量和能量摄 入后,母亲摄入较多的水(p=0.009)和锰(p=0.024)与哮鸣音的降低有关, 摄入较多的葡萄糖与哮鸣音的增加有关(p=0.003)。与摄入最少的四分位数 相比,母亲水摄入最多的四分位数婴儿哮鸣音的发生率... | zh-cn |
pair_25516328 | We examined coffee consumption patterns over the past decade among Korean adults. This study was based on seven different cross-sectional data from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2001 and 2011 (17,367 men and 23,591 women aged 19-103 y, mean 48.1 y). Information on frequen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 我们在过去十年里对韩国成年人的咖啡消费模式进行了调查。此项研究基于 2001 至2011 年韩国国家健康与营养调查研究的七个横断面调查数据(17367 名男性,12591 名女性,年龄为19-103 岁,平均年龄48.1 岁)。咖啡的消费 频率和类型由频率问卷调查或24 小时回顾询问法得到。十年间,每日喝咖啡 的流行率增长了20.3%(从54.6%增加到了65.7%,p<0.001)。每日消费2 杯 和2 杯以上咖啡的人激增了48.8%(从29.1%增加到43.3%,p<0.001)。速溶 咖啡是被韩国成年人消费最频繁的,而且在中年以上人群(年龄>=40 岁)中仍 有增长趋势,但是年轻男性对咖啡的消费量放缓,年轻女性则有下降趋势。近... | zh-cn |
pair_25516329 | Food affordability and quality can influence food choice. This research explores the impact of geographic factors on food pricing and quality in Western Australia (WA). A Healthy Food Access Basket (HFAB) was cost and a visual and descriptive quality assessment of 13 commonly consumed fresh produce items was conducted ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 食品可购性和质量影响食品的选择。本研究探讨了地理因素对西澳大利亚食品 价格和质量的影响。用一个健康食品进入篮(HFAB)评估了144 家有代表性 的食品杂货店的13 种经常食用的新鲜农产品的价格、外观和质量。2010 年西 澳大利亚的零售环境为447 家食品杂货商店服务290 万人口,38%的商店是位 于人口密集地区的两大连锁超市(Coles®澳大利亚超市和Woolworths®有限公 司),50%为位于小区的小型独立经营的商店(独立杂货商协会®),另外 12%的商店是位于非常偏远地区的土著社区。非常偏远地区的HFAB 价格比大 城市高24%(p<0.0001),水果、蔬菜和奶制品分别高32%(p<0.0001)、 26.1%(p<... | zh-cn |
pair_28441814 | As arising incidence of thyroid cancer, the treatment for thyroid carcinoma is becoming increasingly standardized. But there are different opinions on the treatment for some types of thyroid cancers, including the determination of operative opportunity, surgical method, and follow-up observation plan. There are mainly ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着甲状腺癌发病率的不断攀升,甲状腺癌治疗日益规范。但部分甲状腺癌治疗方案的制订仍存在不同的理解:如手术时机、术式选择、观察策略,主要包括两类:一类是经过家系筛查确诊的家族性甲状腺癌突变基因携带者,包括甲状腺髓样癌和非髓样甲状腺癌;另一类是经过细针穿刺细胞学检查确诊并采取观察方案的甲状腺微小癌患者,本文就中国这几类患者的诊治现状进行探讨。. | zh-cn |
pair_28441815 | The prevalence of thyroid nodules, especially differentiated thyroid cancer, has increased during the past decades. With the consideration of increasing prevalence of the diseases, American Thyroid Association (ATA) updated the guidelines for adult patients with thyroid nodules and differentiated thyroid carcinoma (DTC... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 甲状腺结节特别是分化型甲状腺癌(differentiated thyroid carcinoma,DTC)近年来呈高发趋势。随着患者数量以及相关研究的增加,2015年美国甲状腺协会(American Thyroid Association,ATA)更新了甲状腺结节与DTC治疗指南。指南中明确提出其主要目标是:减小对大多数与疾病相关的死亡、复发的风险,并降低对患者的过度治疗带来的潜在危害,而给予高危险患者恰当的治疗和监控。本文对2015年ATA《成人甲状腺结节与分化型甲状腺癌诊治指南》做一解读,主要内容包括:甲状腺结节的筛查、诊断与治疗计划,分化型甲状腺癌的初始外科治疗,分化型甲状腺癌手术后的评估与治疗,分化型甲状腺癌的随访,以及病灶... | zh-cn |
pair_28442009 | Enhanced recovery after surgery (ERAS) is a paradigm shift in perioperative care, resulting in substantial improvements in clinical outcomes, shorter length of hospital stay and cost savings. But the current ERAS either by application of breadth or depth is not enough, why? The main reason is the lack of 'operability, ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 加速康复外科(enhanced recovery after surgery, ERAS)的临床实践已有充分的证据改变了外科手术的结果,缩短住院日并节约费用。但是目前ERAS无论是被应用的广度还是深度却远远不够,原因何在呢?我们分析可能主要原因是缺少'可操作、可评估、可重复'的临床方案。可操作主要是指临床方案简单易行,团队和患者依从性均好;可评估是指方案应用前、中、后均有客观评估标准及处理方案;可重复是临床方案在本单位及推广过程中重复性好。. | zh-cn |
pair_28442010 | Recent studies have indicated that Nm23-H1 is found in the nucleus, but previous studies have been based on the overexpression or suppression of Nm23-H1 in the cytoplasm. Due to the lacking nuclear localization signal of Nm23-H1, these results cannot reflect or repeat cells in which Nm23-H1 mainly positioned in nuclei ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 现有研究发现Nm23-H1还存在胞核表达,而既往的研究都是以过表达或抑制胞浆Nm23-H1为研究手段,由于Nm23-H1本身缺乏核引导序列,其研究结果并不能真实反映或重复临床中Nm23-H1以胞核定位为主的实际生物学效应。因此,本研究通过构建带有核引导序列的Nm23-H1载体并转染A549细胞以探讨Nm23-H1从胞浆向胞核转位对肺癌细胞增殖的影响。方法 采用基因重组技术构建带核定位信号序列的pLentis-CMV-NME1-IRES2-PURO慢病毒载体,酶切和测序鉴定正确后,稳定转染A549细胞后用Western blot和激光共聚焦检测Nm23-H1蛋白的定位和表达,用CCK-8法检测细胞的增殖,流式细胞术检测细胞... | zh-cn |
pair_28442012 | Surgical procedure is the main method of treating lung cancer. Meanwhile, postoperative pneumonia (POP) is the major cause of perioperative mortality in lung cancer surgery. The preoperative pathogenic airway bacterial colonization is an independent risk factor causing postoperative pulmonary complications (PPC). This ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 外科手术是目前治疗肺癌的主要手段,肺癌患者围术期死亡的主要原因仍是术后肺炎。已有的研究结果显示致病性气道定植菌被认为是术后肺部并发症的一个独立危险因素,本研究旨在探讨术前致病性气道定植菌的存在与术后发生肺炎的关系及其危险因素。方法 横断面调查2014年5月至2015年1月连续收治于成都市6家三级甲等医院胸外科行手术治疗的125例非小细胞肺癌患者,术前经纤维支气管镜取气管及支气管内液细菌学标本,并检测术前血清肺表面活性蛋白D(surfactant protein D, SP-D)水平,术后肺部相关并发症进行分析。结果 肺癌患者术前合并致病性气道定植菌的发生率为15.2%(19/125),以革兰氏阴性菌为主(19/22, 8... | zh-cn |
pair_28442013 | Lymph node metastasis is one of the important factors affecting the tumor-node-matastasis (TNM) staging of lung cancer. In patients with surgery, 13 groups and 14 groups of lymph nodes ignored because of the deep hidden in the lung. In this paper, the positive detection rate of 13 groups and the 14 groups of lymph node... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 淋巴结转移是影响肺癌肿瘤-淋巴结-转移(tumor-node-matastasis, TNM)分期的重要因素之一,在非小细胞肺癌(non-small cell lung cancer, NSCLC)患者的手术中,13组、14组淋巴结因其隐藏于肺叶的深部而忽视做病理检测,影响术后病理分期准确性。本研究旨在探讨13组、14组淋巴结在NSCLC术中的阳性检出率及其对病理分期的影响。方法 选取内蒙古医科大学附属医院100例NSCLC手术患者为研究对象,剖取胸内2组-12组、第13、14组淋巴结行病理检测,分析肿瘤的大小、部位、病理类型等因素与胸内淋巴结转移率的关系。结果 100例患者胸内淋巴结转移率为47.0%,10组-12组、... | zh-cn |
pair_28442014 | Standard operation procedure (SOP) could standardize treatment procedure and reduce medical expenses, but SOP drawn by the government may not suit all medical institutions, so individual adjustment made by surgical team is necessary. We recorded the information of patients undergoing lung resection, including postopera... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 医疗流程标准化可提高治疗规范程度、控制合并症和住院时间,但国家制定的临床路径需根据各中心实际情况进行个体化调整。方法 本研究分析单一手术组进行肺切除手术患者的围手术期信息,通过对比术后平均住院日、医疗费用、手术胸腔镜占比等多个因素,从结构性指标、过程性指标、结果性指标三个方面进行了手术质量持续改进的总结和探索,寻找适合本手术组实际情况的理想术后住院时间及质量评估指标。结果 2016年的术后平均住院日较2013年明显缩短[(4.08±1.80) d vs (6.13±3.60) d, P<0.001],全胸腔镜手术占比(17%→48%→68%→73%)及单操作孔胸腔镜占比(0%→2%→52%→66%)四年来显著提高。结论 ... | zh-cn |
pair_28442015 | Progesterone and adiponectin receptor family member 3 (PAQR3) is a recently discovered tumor suppressor gene, which affects the development of a tumor by inhibiting cell proliferation, cell malignant transformation, angiogenesis, and tumor metastasis. This study investigates the expression of PAQR3 in lung cancer and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 孕酮及脂联素受体家族成员3(progesterone and adiponectin receptor family member 3, PAQR3)是最新研究发现的抑癌基因,通过抑制细胞增殖、细胞恶性转化、抑制血管生成及肿瘤转移来影响肿瘤的发展。本研究旨在探讨PAQR3在肺癌组织中的表达及其临床意义。方法 选取天津医科大学总医院病理科2008年1月-2010年12月经病理明确诊断的106例肺癌组织标本作为实验组,同时取其癌旁正常组织作为对照。所有患者的诊断均经术后病理诊断证实,采用免疫组织化学方法检测PAQR3蛋白在肺癌组织和癌旁正常组织中的表达,并探讨其表达的临床意义。结果 PAQR3蛋白在肺癌组织中阳性表达率显著低... | zh-cn |
pair_28442017 | At present, non-small cell lung cancer is one of the highest incidence of cancers in the world, and its incidence increased year by year, this situation prompted people to continue to seek a variety of treatment in order to extend the survival of patients and improve the quality of life of patients. This review aims to... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目前非小细胞肺癌已是世界上发病率最高的癌症之一,且其发病率在逐年增加,这种现状促使人们不断寻求各种治疗手段以期延长患者的生存期,改善患者的生活质量。本综述旨在通过迄今为止有关临床数据,全面讨论贝伐珠单抗在治疗非小细胞肺癌中的应用进展,探讨该药物在临床使用中可能出现的问题、患者的更有效选择以及未来的发展方向。. | zh-cn |
pair_28460510 | Four patients with coexistence of sarcoidosis and primary Sjögren syndrome (pSS) were retrospectively analyzed.All patients were female, who were referred to our department mainly because of respiratory symptoms.Positive antinuclear antibody(ANA) was detected in 2 patients and anti-Sjögrens syndrome A (SSA) antibody po... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 回顾性分析4例结节病并存原发性干燥综合征(pSS)的临床特点并复习相关文献。4例患者均为女性,均以呼吸道症状就诊,抗核抗体阳性2例,抗SSA抗体阳性1例,所有患者均有结节病和干燥综合征的组织病理学证据支持诊断。文献复习41例(包括本组报道的4例),其中女性37例,男性4例,眼干40例,口干38例,肺门、纵隔淋巴结肿大28例,间质性肺炎15例,有呼吸道症状13例,抗核抗体阳性23例,抗SSA抗体阳性19例,抗SSB抗体阳性10例,类风湿因子阳性12例,所有患者均有两种疾病的组织病理学证据。结节病并存pSS时有多系统受累、自身抗体阳性,但最终确诊还需组织病理学依据。. | zh-cn |
pair_28460514 | A 53-year-old woman presented with arthralgia and dyspepsia on exertion.Symmetrical joint swelling and pain of bilateral hands with pigmentation sedimentation in the articular surfaces, dry cough and short of breath were the main clinical manifestations.Elevated levels of erythrocyte sedimentation rate(89 mm/1 h), C-re... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 患者女性,53岁。因多发关节肿痛,活动后气促就诊。临床表现为双手对称性关节肿痛伴关节面色素沉着,活动耐量缓慢下降。ESR(89 mm/1 h)、超敏C反应蛋白(64.45 mg/L)、IgG(31.22 g/L)、IgA(5.44 g/L)升高,类风湿因子阳性,抗环瓜氨酸多肽抗体阴性。胸部高分辨CT示双肺弥漫结节影,片状磨玻璃影,薄壁囊样影等。肺组织病理示大量浆细胞浸润及淀粉样物质沉积。诊断类风湿关节炎、肺间质病变、肺内多发结节。口服泼尼松片7.5 mg、隔日1次,口服沙利度胺50 mg、1次/d,托珠单抗560 mg、静脉输液、1次/月,治疗1个月。胸部CT示肺部结节未见明显变化,肺间质病变缓慢进展。. | zh-cn |
pair_34794215 | Liver cancer is one of the malignant tumors with the highest fatality rate in China and the 5-years survival rate is only 12.5%. Early detection to undertake early treatment can improve the survival rate of patients with liver cancer. Nowadays, the unsatisfactory performance of serum Alpha-fetoprotein (AFP) test, and t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝癌是我国病死率最高的恶性肿瘤之一,患者的5年生存率仅为12.5%,早期发现并及早治疗可提高肝癌患者的生存率。在目前临床常用的肝癌诊断方法中,血清甲胎蛋白(AFP)诊断效能仍不甚满意,而超声对小病灶不敏感,CT存在放射暴露的问题,因而亟需探索新的肝癌诊断相关标志物。在临床症状出现前,肝癌患者血清中就已存在靶向肿瘤相关抗原的自身免疫性抗体(AAB),目前文献报道较多的有抗p53、抗胰岛素样生长因子Ⅱ信使RNA结合蛋白和葡萄糖调节蛋白等AAB。单个AAB在肝癌诊断中的特异度高,但灵敏度较低,多个AAB联合检测可提高肝癌诊断的灵敏度,AAB联合AFP检测可进一步提高肝癌的检出率。目前AAB与肝癌预后关系的研究较少,是未来需要继续探索的方向... | zh-cn |
pair_34794253 | Cutaneous wound is one of the common clinical diseases. Functional materials can provide targeted wound protection and promote wound healing through the structural adjustment and functional integration. Currently, functional materials have been widely used in the field of wound repair, becoming one of the important too... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 皮肤创面是临床常见病症之一。功能材料通过结构调节和性能整合,可以针对性地对创面进行保护并促进创面愈合,目前已在创面修复领域得到广泛应用,是临床创面治疗的重要工具之一。本文分别就止血类、抗菌类、抗炎类、促血管化类及调控创面微环境类功能材料在创面修复中的应用做一总结。. | zh-cn |
pair_34794262 | Diabetes can lead to a variety of complications, such as chronic wound (diabetic foot), which is one of the important causes of death for patients with diabetes. Unfavorable factors such as high blood glucose, high level of oxidative stress and inflammation, and susceptibility to infection lead to difficult healing and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 糖尿病会导致多种并发症如慢性创面(糖尿病足),是导致糖尿病患者死亡的重要原因之一。高血糖、高氧化应激水平、高炎症水平以及易感染等不利因素使糖尿病致慢性创面难以愈合,甚至进一步恶化。水凝胶材料由于具有含水量高、生物相容性好和理化性能可调控等优点,已成为当前创面敷料研究中的热点材料。相较于纱布等传统敷料,水凝胶敷料可为创面提供有利于愈合的湿润环境。通过负载活性物质和改变水凝胶组成及结构,水凝胶敷料可被赋予优异的组织黏附、抗菌、抗氧化以及调控炎症因子表达等功能,因此其在创面敷料应用领域中具有广阔的前景。本文基于糖尿病致慢性创面微环境和水凝胶材料的特点,总结了近年来用于治疗糖尿病致慢性创面的新型多功能水凝胶敷料的研究进展,同时探讨了当前水凝... | zh-cn |
pair_34794263 | Stitching skin wounds is one of the essential skills of a surgeon. Whether it is a traumatic wound or a surgical incision, choosing the most appropriate closure technique according to its characteristics is an important factor for good healing. Various skin wounds suturing techniques have been created and improved over... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 皮肤伤口缝合是外科医师必备技能之一。无论是外伤伤口还是手术切口,根据其特点选择合适的缝合方式是愈合良好的重要因素。多年来,各种皮肤伤口缝合技术不断地涌现,经不断改进后形成了操作简便、对合精准、降低创缘张力及减少瘢痕形成等优势。这些技术虽然为伤口的缝合提供了更多选择,但是也对术者的判断能力和操作能力提出了要求。本文就不同皮肤伤口缝合技术的优点和不足及其临床应用进行综述。. | zh-cn |
pair_34794264 | Wang Bing's perspective included two aspects. One was the annotation of the classical text, focusing on the medical interpretation and the precise interpretation of concepts and terminology, in particular, the annotation of the scriptures related to acupuncture and moxibustion which had a wide and far-reaching influenc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 王冰的“次注”包括2方面:其一,经文的注释,重在医道的阐发和概念术语的精解,对针灸相关经文的注解尤显功力,多有卓见,对宋代及宋以后的针灸文献产生了广泛而深远的影响。其二,经文的改编,可大致分为2类:出于“昭彰圣旨,敷畅玄言”目的的改编;出于“以经注我”之改编。其中第2类改编中的补文王冰刻意掩饰,未按其自定补文体例“朱书其文”。运气“七篇大论”王冰自编自注的可能性最大,是其改编《素问》的一颗重要棋子。不论是从历史还是逻辑的维度考量,王冰对《素问》大尺度的改编都是过远大于功,特别是其刻意掩饰的第2类改编对后人产生的蒙蔽和误导至今仍多不为人所察知。. | zh-cn |
pair_34794265 | The Chuo Ban Chu of Shang Si Yuan in the Qing Dynasty was an institution for Mongolian physicians who provided bone injury diagnosis and treatment for the royal family. This paper reports on an examination of the archives at the First Historical Archives of China, where 171 relevant archives were obtained. Based on thi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 清代上驷院绰班处是由蒙古医生组成的主要为皇室提供骨伤科医疗服务的机构。通过对中国第一历史档案馆馆藏上驷院绰班处相关档案史料进行实地调查,共获得171条档案史料,经整理与考证,总结了清代各朝共112位蒙古医生名录,26位蒙古医生长的承袭情况,并为其中16位蒙古医生撰写了小传。. | zh-cn |
pair_34794266 | The Putuo Mountain, as one of the four famous Buddhist mountains in China, has a long history with Buddhist medicine. Buddhist medicine at Putuo Mountain was developed extensively in the late Qing Dynasty and was shaped with a variety of characteristics resulting in some great achievements. Hua Yu Tang, as a Chinese me... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 晚清以来普陀山的佛医活动内容非常丰富,并且在不同时代呈现出不同特点。清末法雨寺创办“化育堂”中医馆,为僧俗服务,僧医心禅的著作《一得集》流传广泛;民国时期,寺庙创办医院,开设药店,遇疫情灾情开展慈善救济活动;新中国成立后,佛医活动曾一度停顿,寺庙场馆被用于医院疗养院,20世纪80年代,随着佛教组织的恢复,佛医活动也逐渐恢复,并有很大的发展,佛教协会募集资金创办医院,参与疫情灾情的救助工作。. | zh-cn |
pair_34794267 | Several training programs for the pharmacy staff in the Pharmacy Department of Beijing Union Medical College Hospital were implemented over 1910's to 1942, such as apprenticeships, prior courses on pharmaceutical sciences,vocational training, study overseas, and developing the Beiping Pharmacy Evening School in collabo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 从协和医学堂创办至北京协和医院1942年因日本侵略临时关闭,前后30余年,北京协和医院药剂科采用学徒制、药学预科、出国学习、参与创办北平药学讲习所等多种形式,探索本院药学实用型人才的培养,不仅培养出了数名中国本土药学家,保证了医院职工的执业胜任力;而且还支持医院职工面向社会兴办药学职业教育,为中国培养了一批药学专业人员。. | zh-cn |
pair_34794268 | At the beginning of the New China, the first National Health Administration Conference and the first National Health Conference established the health administration policies of the New China, but ignored the training of Chinese medicine successors. After 1954, the policy towards Chinese medicine changed gradually. In ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 新中国成立之初,首届全国卫生行政会议和首届全国卫生会议确立了新中国的卫生行政方针,但忽略了中医后继人才的培养问题。1954年后对中医的政策逐渐转向,1956年卫生部发出《关于开展中医带徒弟工作的指示》,同时公布了《1956—1962年全国中医带徒弟的规划》(草案),中医带徒弟作为政府的卫生行政政策被确立。尽管由于最初规划粗疏,各地条件差异判若霄壤,最初的执行并不顺利,但仍是新中国培养中医新生力量、保障中医后继有人的重要政策措施之一。. | zh-cn |
pair_34794269 | Smallpox was believed afferent before the Sui Dynasty. Some relatively accurate descriptions about smallpox were found in the Sui and Tang Dynasties. Smallpox was recognized as a severe infectious disease caused by pathogenic heat by the observation of its symptoms and appearance. It was believed that smallpox was caus... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 隋以前天花已经传入中国,隋唐时期对天花已经有了较为准确的描述,已经意识到其为烈性传染病,能够通过症状和天花的外观初判预后,认为天花是热毒所致,是伤寒的一种。北宋早期认为痘疮是由于脏腑积热,后期提出了天花是胎儿吸食了母体的秽液导致,为胎毒说之雏形;已经能够辨别水痘、麻疹及天花的不同。明清时期,“胎毒”外感说已成为主流;观察到感染一次天花以后不会再感染这一免疫现象;对天花的症状有了细致描述,能准确预后。可以看出古代医家们对于天花的认识是随着时间的进展不断深入的,这些认识为人痘接种术的发明奠定了基础。. | zh-cn |
pair_34794272 | The historical artifacts displayed in the Museum of Western study on Chinese Medicine at Yunnan University of Chinese Medicine came from a variety of Chinese medical schools in America and European countries. They are in the memorial galleries for some well-known figures, such as George Soulié de Morant (Su Lie), Jacqu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 中医西学博物馆坐落于云南中医药大学,2013年正式开放,基于人类学“他者”研究视角,成为世界首座展示西方中医的人类学博物馆。博物馆系统展示了欧美各式中医流派的发展与现状,有苏烈(George Soulié de Morant)、腊味爱(Jacques-André Lavier)、满福利(Felix Mann)和满晰博(Manfred Porkert)等具有代表性的西方中医药大家的纪念廊。2020年,该馆有6件藏品被认定为国家级珍贵文物,通过介绍博物馆的纪念廊及重要藏品,以期更多人了解西方人如何认识、学习和发展中医,从而更好地传播中医药文化。. | zh-cn |
pair_34796560 | The stratum corneum (SC), the outermost layer of the epidermis, serves a crucial role in maintaining body hydration and protection from environmental insults. When the stratum corneum is injured or when the genetic blueprints are flawed, the body is at risk of dehydration, secondary infections and allergen sensitizatio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 角质化是角质细胞从表皮基底层向高度特化的角质层(SC)终末分化的过程。术语cornification(角质化)和keratinisation(角质化)通常作为同义词使用;差异来自其希腊语(keras)与拉丁语(cornu)推导。完全分化的角化细胞最终以皮屑的形式脱落到环境中。在常规染色的光学显微镜下, 表皮最外层显示为薄的嗜酸性交错层 (所谓的“篮网”排列) , 这是组织处理过程中细胞间脂质损失产生的伪影 (图1) 。尽管历来SC都被忽略为组织废弃物, 但已知其对于维持身体水合和防止环境损害不可或缺。事实上, 获取疏水性SC是进化的主要成就, 允许胆大的水生哺乳动物离开水域来到陆地定居。<sup>1</sup> 应该注意的是, 我们... | zh-cn |
pair_34796560 | The stratum corneum (SC), the outermost layer of the epidermis, serves a crucial role in maintaining body hydration and protection from environmental insults. When the stratum corneum is injured or when the genetic blueprints are flawed, the body is at risk of dehydration, secondary infections and allergen sensitizatio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La cornéogénèse est le processus par lequel les kératinocytes subissent une différenciation terminale de la couche basale de l'épiderme à la couche cornée hautement spécialisée (SC). Les termes cornéogénèse et kératinisation sont souvent utilisés comme synonymes ; la différence résulte de leur dérivation grecque (keras... | fr |
pair_34796560 | The stratum corneum (SC), the outermost layer of the epidermis, serves a crucial role in maintaining body hydration and protection from environmental insults. When the stratum corneum is injured or when the genetic blueprints are flawed, the body is at risk of dehydration, secondary infections and allergen sensitizatio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Verhornung (Cornifizierung) ist der Prozess, bei dem Keratinozyten ihre terminale Differenzierung von der Basalschicht der Epidermis bis zum hochspezialisierten Stratum corneum (SC) durchlaufen. Der Ausdruck Verhornung (Cornifizierung) und Keratinisierung werden oft synonym verwendet; der Unterschied stammt aus ihr... | de |
pair_34796560 | The stratum corneum (SC), the outermost layer of the epidermis, serves a crucial role in maintaining body hydration and protection from environmental insults. When the stratum corneum is injured or when the genetic blueprints are flawed, the body is at risk of dehydration, secondary infections and allergen sensitizatio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Cornificação é o processo pelo qual os queratinócitos sofrem diferenciação terminal desde a camada basal da epiderme até o altamente especializado estrato córneo (SC). Os termos cornificação e queratinização são frequentemente usados como sinônimos; a diferença resulta de sua derivação grega (keras) versus latina (corn... | pt |
pair_34796560 | The stratum corneum (SC), the outermost layer of the epidermis, serves a crucial role in maintaining body hydration and protection from environmental insults. When the stratum corneum is injured or when the genetic blueprints are flawed, the body is at risk of dehydration, secondary infections and allergen sensitizatio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La cornificación es el proceso mediante el cual los queratinocitos experimentan una diferenciación terminal desde la capa basal de la epidermis hasta el estrato córneo (SC) altamente especializado. Los términos cornificación y queratinización se utilizan a menudo como sinónimos; la diferencia resulta de su derivación g... | es |
pair_34796561 | Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro-organisms. Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S. pseudintermedius.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 假中间型葡萄球菌是犬脓皮病的主要病原。全基因组测序是获得微生物相关基因组信息最全面的方式。 假设/目的: 纳米孔技术能够对假中间型葡萄球菌的全基因组进行质量测序和从头组装。对假中间型葡萄球菌进行全基因组分析可能有助于更好地了解犬脓皮病的发病机制。 方法和材料: 从5只健康犬皮肤中分离的22株,以及从33只脓皮病犬皮肤中分离的33株假中间型葡萄球菌,对其进行分析。使用纳米孔 MinION提取DNA并测序,这是一种手持设备,这种新技术可传递更长的测序片段。用ANVI'O 6.1分析全基因组并将其可视化。 结果: 从健康犬和脓皮病犬中分离的55株假中间型葡萄球菌,用纳米孔技术对其基因组进行测序和从头组装。假中间型葡萄球菌的平均基因... | zh-cn |
pair_34796561 | Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro-organisms. Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S. pseudintermedius.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Staphylococcus pseudintermedius est le principal agent étiologique de la pyodermite canine. Le séquençage du génome entier est le moyen le plus complet d'obtenir des informations génomiques pertinentes sur les micro-organismes. HYPOTHÈSE/OBJECTIFS: La technologie Oxford Nanopore permet un séquençage de qualité et un as... | fr |
pair_34796561 | Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro-organisms. Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S. pseudintermedius.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Staphylococcus pseudintermedius stellt die hauptsächliche ätiologische Ursache für die canine Pyodermie dar. Eine Gesamtgenomsequenzierung ist der umfassendste Weg, um relevante Genominformation über Mikroorganismen zu erhalten. Die Oxford Nanopore Technologie ermöglicht eine qualitative Sequenzierung und eine de novo ... | de |
pair_34796561 | Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro-organisms. Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S. pseudintermedius.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Staphylococcus pseudintermedius é o principal agente etiológico da piodermite canina. O sequenciamento completo do genoma é a forma mais aprofundada de se obter informações genômicas relevantes sobre microrganismos. HIPÓTESE/OBJETIVOS: A tecnologia de Oxford Nanopore permite o sequenciamento de boa qualidade e montagem... | pt |
pair_34796561 | Staphylococcus pseudintermedius is the main aetiological agent of canine pyoderma. Whole genome sequencing is the most comprehensive way of obtaining relevant genomic information about micro-organisms. Oxford Nanopore technology enables quality sequencing and de novo assembly of the whole genome of S. pseudintermedius.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Staphylococcus pseudintermedius es el principal agente etiológico de la pioderma canina. La secuenciación del genoma completo es la forma más completa de obtener información genómica relevante sobre microorganismos. HIPÓTESIS/OBJETIVOS: la tecnología Oxford Nanopore permite la secuenciación de calidad y el ensamblaje d... | es |
pair_34796563 | Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. The antimicrobial effect of olanexidine was evaluated using minimal inhibit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 外部治疗可能有益于管理犬浅表脓皮病。一种新型抗菌剂奥兰西丁最近可用于人,其作为外部治疗对犬脓皮病的疗效尚不清楚。 目的: 通过对假中间型葡萄球菌的最小抑菌浓度(MIC),评价奥兰西丁的抗菌作用。此外,在一项随机、单盲研究中,评估其在犬浅表脓皮病中的临床有效性。 动物: 28只患有特应性皮炎和浅表脓皮病的宠物犬。 方法和材料: 通过96孔微量肉汤稀释法的系列稀释,测定假中间型葡萄球菌分离株(n = 73)的奥兰西丁 MIC。临床试验中,所有招募的犬被随机分为两组;一组接受1.5%奥兰西丁喷雾剂,每日一次治疗,另一组接受3%氯己定香波每周一次治疗,连续2次。根据日本动物抗菌剂协会的指导原则,在第0天和第14天进行临床评估。 结果... | zh-cn |
pair_34796563 | Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. The antimicrobial effect of olanexidine was evaluated using minimal inhibit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les traitements topiques peuvent être bénéfiques pour la gestion de la pyodermite superficielle canine. Un nouvel agent antiseptique, le gluconate d'olanexidine, est devenu disponible récemment pour une utilisation chez l'homme, et son efficacité pour la pyodermite canine en tant que thérapie topique est inconnue. L'ef... | fr |
pair_34796563 | Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. The antimicrobial effect of olanexidine was evaluated using minimal inhibit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Topische Behandlungen können sich beim Management der superfiziellen Pyodermie des Hundes günstig auswirken. Ein neuer antiseptischer Wirkstoff, Olanexidin Gukonat, steht in der letzten Zeit für die Verwendung beim Menschen zur Verfügung. Seine Wirksamkeit bei caniner Pyodermie als topische Therapie ist unbekannt. ZIEL... | de |
pair_34796563 | Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. The antimicrobial effect of olanexidine was evaluated using minimal inhibit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | INTRODUÇÃO: Os tratamentos tópicos podem ser benéficos para o manejo da piodermite superficial canina. Um novo agente anti-séptico, gluconato de olanexidina, tornou-se recentemente disponível para uso em humanos, e sua eficácia para piodermite canina como terapia tópica é desconhecida. O efeito antimicrobiano da olanex... | pt |
pair_34796563 | Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. The antimicrobial effect of olanexidine was evaluated using minimal inhibit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | los tratamientos tópicos pueden ser beneficiosos para controlar la pioderma superficial canina. Un nuevo agente antiséptico, el gluconato de olanexidina, se ha aprobado recientemente para su uso en humanos, y se desconoce su eficacia para la pioderma canina como terapia tópica. OBJETIVO: se evaluó el efecto antimicrobi... | es |
pair_34796564 | To optimise the interleukin (IL)-31-blocking therapy in atopic dermatitis (AD), an understanding of the chronology in the expression of IL-31 and its receptor (IL-31RA) is needed. (i) To assess the chronological expression of IL-31 in canine AD skin lesions, (ii) to compare it with serum IL-31 levels and macroscopic sk... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 为了优化特应性皮炎(AD)中的白介素(IL)-31阻断治疗, 需要了解IL-31及其受体(IL-31RA)表达的时间顺序。 假设/目的: (i)评估犬AD皮肤病变中IL-31的时间表达顺序, (ii)将其与血清IL-31水平和肉眼可见皮肤病变评分进行比较, 以及(iii)测定IL-31和IL-31RA阳性细胞的一致性。 动物: 4只对室内尘螨过敏的特应性皮炎患犬。 方法: 过敏原激发后0h、24h、48h和96h采集皮肤和血液样本。进行IL-31和IL-31RA单染免疫荧光(IF),以及IL-31/CD3、IL-31/CD4和IL-31RA/β3-微管蛋白双染IF。对IL-31阳性细胞进行主观计数。 结果: 3/4的犬在激发... | zh-cn |
pair_34796564 | To optimise the interleukin (IL)-31-blocking therapy in atopic dermatitis (AD), an understanding of the chronology in the expression of IL-31 and its receptor (IL-31RA) is needed. (i) To assess the chronological expression of IL-31 in canine AD skin lesions, (ii) to compare it with serum IL-31 levels and macroscopic sk... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Pour optimiser la thérapie bloquant l'interleukine (IL)-31 dans la dermatite atopique (DA), une compréhension de la chronologie de l'expression de l'IL-31 et de son récepteur (IL-31RA) est nécessaire. HYPOTHÈSE/OBJECTIFS: (i) Évaluer l'expression chronologique de l'IL-31 dans les lésions cutanées de la DA chez le chien... | fr |
pair_34796564 | To optimise the interleukin (IL)-31-blocking therapy in atopic dermatitis (AD), an understanding of the chronology in the expression of IL-31 and its receptor (IL-31RA) is needed. (i) To assess the chronological expression of IL-31 in canine AD skin lesions, (ii) to compare it with serum IL-31 levels and macroscopic sk... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Um die blockierende Therapie mit Interleukin (IL)-31 bei atopischer Dermatitis (AD) zu optimieren, ist ein besseres Verständnis der Chronologie bei der Exprimierung von IL-31 und seines Rezeptors (IL-31RA) nötig. HYPOTHESE/ZIELE: (i) Eine Erfassung der chronologischen Exprimierung von IL-31 in Hundehaut mit AD Veränder... | de |
pair_34796564 | To optimise the interleukin (IL)-31-blocking therapy in atopic dermatitis (AD), an understanding of the chronology in the expression of IL-31 and its receptor (IL-31RA) is needed. (i) To assess the chronological expression of IL-31 in canine AD skin lesions, (ii) to compare it with serum IL-31 levels and macroscopic sk... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Para otimizar a terapia bloqueadora de interleucina (IL)-31 na dermatite atópica (DA), é necessária a compreensão da cronologia da expressão de IL-31 e de seu receptor (IL-31RA). HIPÓTESE/OBJETIVOS: (i) avaliar a expressão cronológica de IL-31 na pele lesional de cães com DA, (ii) comparar aos níveis séricos de IL-31 e... | pt |
pair_34796564 | To optimise the interleukin (IL)-31-blocking therapy in atopic dermatitis (AD), an understanding of the chronology in the expression of IL-31 and its receptor (IL-31RA) is needed. (i) To assess the chronological expression of IL-31 in canine AD skin lesions, (ii) to compare it with serum IL-31 levels and macroscopic sk... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | para optimizar la terapia de bloqueo de interleucina (IL) -31 en la dermatitis atópica (AD), se necesita una comprensión de la cronología en la expresión de IL-31 y su receptor (IL-31RA). HIPÓTESIS / OBJETIVOS: (i) Evaluar la expresión cronológica de IL-31 en lesiones cutáneas de la EA canina, (ii) compararla con los n... | es |
pair_34796565 | In human medicine, narrow-band ultraviolet B (NB-UVB) phototherapy has been used to treat various T-cell-mediated skin diseases. However, the effect of NB-UVB on inflamed canine skin remains uncertain. To investigate the effect of NB-UVB phototherapy on the skin of dogs with hapten-induced contact dermatitis. Seven hea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 在人类医学中, 窄谱中波紫外线(NB-UVB)光疗已被用于治疗各种T细胞介导的皮肤病。然而, NB-UVB对犬发炎皮肤的影响仍不确定。 目的: 半抗原诱导出犬接触性皮炎,研究NB-UVB光疗对皮肤的影响。 动物: 7只健康比格犬, 无皮肤问题。 方法和材料: 用不同剂量的NB-UVB照射犬, 测定最小红斑剂量(MED)。在确定了6只犬的MED后 (不包括1只皮肤无可见反应的犬) , 我们研究NB-UVB对发炎皮肤的影响,通过局部涂抹2,4-二硝基氯苯(DNCB),引起1型辅助性T细胞(Th1)和细胞毒性T细胞(Tc)1诱导的皮肤炎症。然后我们用NB-UVB照射皮肤。我们通过组织病理学和免疫组织化学方法分析了治疗的皮肤样本, ... | zh-cn |
pair_34796565 | In human medicine, narrow-band ultraviolet B (NB-UVB) phototherapy has been used to treat various T-cell-mediated skin diseases. However, the effect of NB-UVB on inflamed canine skin remains uncertain. To investigate the effect of NB-UVB phototherapy on the skin of dogs with hapten-induced contact dermatitis. Seven hea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | En médecine humaine, la photothérapie ultraviolette B (NB-UVB) à bande étroite a été utilisée pour traiter diverses maladies de la peau à médiation par les lymphocytes T. Cependant, l'effet de NB-UVB sur la peau canine enflammée reste incertain. Étudier l'effet de la photothérapie NB-UVB sur la peau de chiens atteints ... | fr |
pair_34796565 | In human medicine, narrow-band ultraviolet B (NB-UVB) phototherapy has been used to treat various T-cell-mediated skin diseases. However, the effect of NB-UVB on inflamed canine skin remains uncertain. To investigate the effect of NB-UVB phototherapy on the skin of dogs with hapten-induced contact dermatitis. Seven hea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | In der Humanmedizin wird die Schmalband Ultraviolet B (NB-UVB) Phototherapie verwendet, um verschiedene T-Zell-mediierte Hauterkrankungen zu behandeln. Die Auswirkung von NB-UVB auf entzündete Hundehaut bleibt jedoch noch unklar. Eine Untersuchung der Auswirkung von NB-UVB Phototherapie auf die Haut von Hunden mit Hapt... | de |
pair_34796565 | In human medicine, narrow-band ultraviolet B (NB-UVB) phototherapy has been used to treat various T-cell-mediated skin diseases. However, the effect of NB-UVB on inflamed canine skin remains uncertain. To investigate the effect of NB-UVB phototherapy on the skin of dogs with hapten-induced contact dermatitis. Seven hea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Na medicina humana, a fototerapia ultravioleta B de banda curta (NB-UVB) tem sido usada para tratar várias doenças cutâneas mediadas por células T. No entanto, o efeito de NB-UVB na pele canina inflamada permanece incerto. Investigar o efeito da fototerapia NB-UVB na pele de cães com dermatite de contato induzida por h... | pt |
pair_34796565 | In human medicine, narrow-band ultraviolet B (NB-UVB) phototherapy has been used to treat various T-cell-mediated skin diseases. However, the effect of NB-UVB on inflamed canine skin remains uncertain. To investigate the effect of NB-UVB phototherapy on the skin of dogs with hapten-induced contact dermatitis. Seven hea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | en medicina humana, la fototerapia ultravioleta B de banda estrecha (NB-UVB) se ha utilizado para tratar diversas enfermedades de la piel mediadas por células T. Sin embargo, el efecto de NB-UVB sobre la piel canina inflamada sigue siendo incierto. OBJETIVOS: investigar el efecto de la fototerapia NB-UVB en la piel de ... | es |
pair_34802205 | The International Agency for Research on Cancer (IARC) published the World Health Organization (WHO) classification of thoracic tumors (5th edition) in May 2021, only six years after the 4th edition of WHO Classification. With the application of low-dose spiral computed tomography (CT) as an early screening method for ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:肺腺癌的最早期:
原位腺癌的病理诊断和临床意义】 【中文摘要:第五版《世界卫生组织(World Health Organization, WHO)胸部肿瘤分类》(2021版分类)已于2021年5月正式出版,距离上一版2015版WHO分类不过只有短短6年时间。随着近年来低剂量螺旋计算机断层扫描(computed tomography, CT)作为早期肺部肿瘤筛查手段的应用,肺腺癌早已成为许多医院手术治疗的优势病种。WHO分类作为指导病理诊断的权威指南,任何一处细微的变动都牵扯病理、临床及患者的心弦。原位腺癌为2015版分类新增加的腺癌诊断,也是近年来国内外临床及研究的焦点,因新版分类对其目录位置进行了一定调整,由此在临床医... | zh-cn |
pair_34802206 | Segmentectomy has gradually become one of the standard surgical methods for small pulmonary nodules with early lung cancer on imaging. This study aimed to investigate the perioperative outcomes of patients who underwent uniport video-assisted thoracoscopic surgery (VATS) segmentectomy for identifying the intersegmental... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:荧光法在单孔胸腔镜解剖性肺段切除术中
识别段间交界线的可行性研究】 【中文摘要:背景与目的 肺段切除术逐渐成为影像学上表现为早期肺癌的肺部小结节的标准手术方式之一。本研究通过对比单孔胸腔镜下荧光法与改良膨胀萎陷法在界定段间交界线的围手术期结果,评估荧光法应用于肺段切除术的有效性和可行性。方法 回顾性分析2018年2月-2020年8月期间在南京胸科医院胸外科接受单孔胸腔镜肺段切除术的连续198例患者的围手术期数据。在三维智能交互式定性和定量分析(intelligent/interactive qualitative and quantitative analysis-three dimensional, IQQA-3D)图... | zh-cn |
pair_34802208 | As the main type of lung cancer, non-small cell lung cancer (NSCLC) is a common cancer which is characterized by low 5-year survival rate and worse prognosis. Nowadays, some studies show that the low survival rate and worse prognosis are due to the resistance to radiotherapy caused by circRNA. Therefore, to find out th... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:环状RNA在非小细胞肺癌放疗抵抗中的
研究进展】 【中文摘要:非小细胞肺癌(non-small cell lung cancer, NSCLC)作为临床上较为常见的癌症,主要特点是患者5年生存率低、预后偏差。目前有部分研究认为生存率低、预后偏差是由于环状RNA(circluar RNA, circRNA)引起了放疗抵抗。因此,找出circRNA与NSCLC放疗抵抗之间的联系,可为改善临床治疗提供理论基础。通过查阅相关文献,找出circRNA与NSCLC放疗抵抗的关系。CircRNA在NSCLC细胞的侵袭、转移、增殖和治疗抵抗中起着重要的作用,其中它所诱导的肿瘤细胞放疗抵抗已经成为放射治疗上的一个重点关注问题。CircRN... | zh-cn |
pair_34802209 | Lung cancer is a malignant tumor with the highest mortality in the world. The most common pathological type of lung cancer is non-small cell lung cancer (NSCLC). In recent years, immunotherapy has brought about epoch-making changes in the treatment of NSCLC. In particular, immune checkpoint inhibitors (ICIs) targeting ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:非小细胞肺癌免疫治疗生物标志物的
研究进展】 【中文摘要:肺癌是全球死亡率最高的恶性肿瘤,非小细胞肺癌(non-small cell lung cancer, NSCLC)是其最常见的病理类型。近年来,免疫治疗给NSCLC的治疗带来划时代的变革,尤其是针对程序性死亡受体1(programmed cell death 1, PD-1)/程序性死亡配体1(programmed cell death ligand 1, PD-L1)的免疫检查点抑制剂(immune checkpoint inhibitors, ICIs),目前已被批准用于转移性NSCLC或部分局部晚期NSCLC患者的一线治疗和二线治疗。然而,仅15%-30%晚... | zh-cn |
pair_34802210 | Pulmonary neuroendocrine tumors (PNETs) are a kind of epithelial tumors originating from pulmonary neuroendocrine cells, accounting for about 20% of primary lung tumors, including typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. The morphologic and clinical character... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:晚期肺神经内分泌肿瘤免疫检查点抑制剂
治疗进展】 【中文摘要:肺神经内分泌肿瘤(pulmonary neuroendocrine tumors, PNETs)是一种源于肺神经内分泌细胞的上皮性肿瘤,约占原发性肺肿瘤的20%,包括典型类癌、非典型类癌、小细胞癌和大细胞神经内分泌癌。这四类PNETs之间的形态学和临床特征具有较大的异质性。免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)已在多种实体瘤中被证实具有很强的抗肿瘤活性。晚期PNETs治疗方案在过去十年内已有了很大的发展,但ICIs在PNETs领域的应用才刚刚起步。本文主要阐述目前PNETs中ICIs临床试验和研究的格局以及免疫... | zh-cn |
pair_34802211 | Small cell lung cancer (SCLC) is a neuroendocrine tumor with fast progression, high malignancy, easy recurrence, and extremely poor prognosis. In the past 30 years, the clinical treatment strategy of SCLC has been mainly chemotherapy and radiotherapy, but the curative effect is not significant; the current immunotherap... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:免疫检查点抑制剂在小细胞肺癌治疗中的
应用与临床试验进展】 【中文摘要:小细胞肺癌(small cell lung cancer, SCLC)是一种神经内分泌型肿瘤,病情进展快、恶性程度高、易复发、预后极差。在过去的30余年中,SCLC的临床治疗策略以化疗和放疗为主,但疗效并不显著;当前SCLC的免疫治疗逐渐进入临床,并取得了一定的进展。肿瘤的免疫治疗包括免疫检查点抑制剂、肿瘤疫苗、细胞因子、嵌合抗原受体T细胞免疫疗法(chimeric antigen receptor T-cell immunotherapy, CAR-T)等,目前以免疫检查点抑制剂的应用最为广泛。本文总结了免疫检查点抑制剂的原理和相关药物,汇总了它们... | zh-cn |
pair_34802212 | Lung cancer is a leading cause of cancer-related morbidity and mortality globally, which is the biggest menace to the health and life of the population. Screening and early detection of lung cancer are effective in reducing its mortality, and the measurement of volatile organic compounds (VOCs) has become a promising c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:VOCs采集与分析技术在肺癌诊疗中的
研究进展】 【中文摘要:肺癌是全球范围内发病率和死亡率最高,对人群健康和生命威胁最大的恶性肿瘤之一。筛查与早诊早治是降低人群肺癌死亡率的有效措施。挥发性有机化合物 (volatile organic compounds, VOCs)检测以快捷性、无创性、采样方便成为一种具有广泛前景的检测手段,可用于肺癌的早期发现,病程检测及预后管理。目前国内外涌现出了多种VOCs采集设备及分析技术,本综述主要从VOCs采集技术、分析技术以及在肺癌诊疗中的应用研究进展三方面探讨VOCs研究目前所存在的问题及研究前景。
】 【中文关键词:肺肿瘤;挥发性有机化合物;采集与分析;早期诊断】. | zh-cn |
pair_34802213 | Osimertinib-induced interstitial lung disease (ILD) is an uncommon, but fatal pulmonary toxicity in some patients. We report a case of a 64-year-old male with stage IV adeno-non-small cell lung cancer (NSCLC) harboring an exon 19 deletion in the epidermal growth factor receptor (EGFR) treated with osimertinib 80 mg/d f... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:EGFR突变非小细胞肺癌患者奥希替尼诱导间质性肺疾病后奥希替尼再挑战:病例报道】 【中文摘要:奥希替尼诱导的间质性肺疾病(interstitial lung disease, ILD)是一种罕见的、致命的肺毒性疾病。我们报道1例64岁男性IV期肺腺癌患者,伴有表皮生长因子受体(epidermal growth factor receptor, EGFR)外显子19缺失,使用奥希替尼80 mg/d作为一线靶向治疗。奥希替尼开始治疗后第60天患者出现ILD。立即停用奥希替尼,并开始口服泼尼松60 mg/d,ILD在13 d内得到改善。权衡风险和获益后,再次开始奥希替尼与泼尼松治疗。奥希替尼治疗16个月以上,患者既没有疾病进展... | zh-cn |
pair_34802214 | Small cell lung cancer (SCLC) is the most malignant lung cancer with the highest mortality. At present, the first-line standard treatment is still based on Etoposide and Platinum chemotherapy. However, for SCLC that progresses after first-line therapy, the treatment options are still very limited. Since the molecular m... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目:小细胞肺癌合并腺癌MDT治疗报道及
文献综述】 【中文摘要:小细胞肺癌(small cell lung cancer, SCLC)是肺癌中恶性程度和死亡率最高的类型。目前的一线标准治疗方式仍是以依托泊苷和铂类为主的化疗方案。然而,对于一线治疗后进展的SCLC,治疗方式仍非常有限。由于目前对SCLC一线耐药的分子机制尚未明了,而且一线耐药后的精准医疗策略仍处于临床前期阶段,因而在SCLC一线治疗进展后,进行二次活检及基因检测的比例很低。本文通过报道1例初次诊断为SCLC的中年女性,病程中多次活检发现肿瘤组织病理学类型出现具有敏感基因突变的腺癌以及小细胞癌的反复转变,提示其可能为SCLC中的特殊亚型——混合型小细胞肺癌(mi... | zh-cn |
pair_34808743 | Minimally invasive interventional analgesia technique is one of the core diagnosis and treatment techniques of the pain department. It can diagnose and treat many pain diseases such as chronic musculoskeletal pain, chronic neuropathic pain and chronic cancer pain with less trauma and good effect. With the emergence of ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 微创介入镇痛技术是疼痛科的核心诊疗技术,能对慢性肌肉骨骼疼痛、慢性神经病理性疼痛、慢性癌性疼痛等疾病进行创伤小、效果好的临床诊治,随着新理念、新材料的涌现,微创介入镇痛在慢性疼痛疾病诊疗中的应用范围越来越广,以实现慢性疼痛疾病的精准诊疗和全程质量管理。. | zh-cn |
pair_34808744 | Knee osteoarthritis (KOA) is a worldwide disease, and also the main cause of pain and disability in the motor system. Due to the aging population in China, extension of life expectancy and increased number of obese people, the number of people affected by KOA continues to surge. Neither surgical nor non-surgical treatm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 膝骨关节炎(KOA)是一种全球性疾病,也是运动系统疼痛和残疾的主要原因。由于中国人口普遍老龄化、预期寿命延长和肥胖人数增加,受KOA影响的人数不断增加。手术治疗和非手术治疗都不能改变疾病进程,但这些干预措施可以减轻疼痛和残疾。KOA的治疗原则是从非手术治疗开始,因其并发症少、创伤小、医疗费用低等优点被认为是KOA患者的首选治疗方法。本文对KOA的非手术治疗方面进行了阐述,旨在为临床上KOA的治疗提供思路。. | zh-cn |
pair_34808755 | The data of clinical characteristics, medical cost and prognosis of 22 anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis children from the Department of Neurology, Capital Institute of Pediatrics between May 2018 and January 2021 were analyzed, and 6 of them occurred paroxysmal sympathetic hyperactivity synd... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 分析了2018年5月至2021年1月首都儿科研究所附属儿童医院神经内科收治的22例抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎中,6例伴发交感神经过度兴奋综合征(PSH)患儿的临床特征、花费及预后,发现伴PSH的抗NMDAR脑炎意识障碍重(入院时GCS中位评分7.5分)、意识障碍持续时间长(中位天数53 d)、住院花费高(中位花费23.0万元)、起病时神经功能损伤重(入院时mRS中位分数4分)、神经功能恢复时间长(mRS恢复至0~2分,中位时间7个月),与不伴PSH的抗NMDAR脑炎患儿比较差异均有统计学意义(<i>P</i><0.05)。故应重视抗NMDAR脑炎的交感神经兴奋症状,早期识别并干预PSH,以期减少疾病对患者神经功能... | zh-cn |
pair_34814382 | Clinically, chronic hepatitis B and C are the main common chronic liver diseases that lead to cirrhosis and liver cancer, followed by drug-induced liver injury, alcohol and metabolic-associated fatty liver disease, and autoimmune liver disease in adult, but, by contrast, some special liver diseases, including pregnancy... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 临床上常见的成人慢性肝病主要是慢性乙型和丙型肝炎以及其导致的肝硬化和肝癌,其次是药物性肝损伤、酒精及代谢相关脂肪性肝病、自身免疫性肝病等。除常见的慢性肝病外,一些特殊肝病,包括妊娠相关肝病、肝内分泌功能异常相关肝损伤、成人遗传性肝病和非嗜肝病毒引起的肝炎等也在逐渐增加。只有对这些特殊肝病进行早期识别和诊断,才能给予及时正确的治疗。. | zh-cn |
pair_34814383 | Epstein-Barr virus (EBV) infection is closely associated to liver injury with diverse clinical features in adolescents and adults. It is often manifested as infectious mononucleosis syndrome, sometimes causing self-limited acute hepatitis, with mild to moderate elevation of liver transaminases, and relative increase in... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | EB病毒(EBV)感染与青少年和成人肝损伤密切相关,临床特征多样。常表现为传染性单核细胞增多症时的急性自限性肝炎,特点是以转氨酶轻、中度升高为主,随年龄增加病情相对加重。EBV感染还可致淤胆型肝炎,以碱性磷酸酶和γ-谷氨酰转移酶升高为主要表现,伴不同程度黄疸。少数EBV感染严重者可出现肝衰竭,如果不能及时治疗,病死率较高。此外,EBV感染与慢性肝炎、肝硬化、自身免疫性肝病等有一定关联。. | zh-cn |
pair_34814384 | There are many types of inherited metabolic liver diseases, with diverse and non-specific clinical manifestations. Therefore, the problem of misdiagnosis and missed diagnosis is more prominent in clinical practice, and it is a problematic issue encountered by clinicians. The dependency of diagnosis is on comprehensive ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 遗传代谢性肝病种类繁多,临床表现多样且无特异性,临床上误诊、漏诊问题较为突出,是临床医师面临的棘手问题。其诊断依赖于对临床表现、实验室检查、影像学检查、肝活检以及基因检测的综合分析。现将遗传代谢性肝病的诊断思路进行总结。. | zh-cn |
pair_34814385 | Pregnancy-related liver disease is a group of severe diseases that usually resulting in worsening clinical outcome in pregnant women and fetuses. Therefore, diagnosis and treatment at early-stage are essential. This paper reviews the early-stage clinical features, pathogenesis, diagnosis and treatment key points of com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 妊娠相关肝病是严重危害孕妇和胎儿健康的一组严重疾病,早期诊断和治疗至关重要。现将临床常见的妊娠相关肝病:妊娠剧吐、妊娠肝内胆汁淤积症、溶血肝酶增高血小板减少综合征和妊娠急性脂肪肝等的临床特点、发病机制、早期诊断及治疗要点进行综述,帮助临床医师提高对妊娠相关肝病的认知。. | zh-cn |
pair_34814386 | The thyroid gland is the largest endocrine gland in the human body, which mainly secretes thyroid hormones. Thyroid hormone acts on almost all tissues and cells at different level regulating growth and development, metabolism and other functional activities of the body. Therefore, abnormal thyroid function can affect t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 甲状腺是人体最大的内分泌腺,主要分泌甲状腺激素。甲状腺激素几乎作用于机体所有组织及细胞,多层次、多水平地调节机体的生长发育、新陈代谢等功能活动。甲状腺功能出现异常时,可累及全身多脏器,而肝脏作为全身最大的生化工厂,广泛地受到甲状腺激素的调节,是甲状腺重要的靶器官之一。甲状腺功能亢进症(简称甲亢)是内分泌系统常见病,可引起肝脏损害,表现为肝肿大、肝功能异常、黄疸甚至肝硬化、肝衰竭等,称为甲亢性肝损伤,多见于新发或未治疗或治疗不当的甲亢患者。在开始抗甲状腺药物(ATD)治疗前,应检查基础肝功能,一方面用于明确甲亢本身导致的肝损伤程度,另一方面用以鉴别ATD引起的药物性肝损伤。治疗甲亢性肝损伤的核心应是迅速控制甲亢,当甲亢得到控制时肝功能... | zh-cn |
pair_34814387 | Hepatocellular carcinoma is a common malignant tumor with a very heavy disease burden in China. Screening and surveillance are effective measures to improve the early diagnosis and treatment and survival rate of patients with hepatocellular carcinoma. Chronic hepatitis B virus infection is the main cause of hepatocellu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝细胞癌是我国常见恶性肿瘤,疾病负担十分沉重。筛查和监测是提高肝细胞癌患者早诊早治和生存率的有效措施。慢性乙型肝炎病毒感染是我国肝细胞癌的主要病因,有必要制定专门的筛查和监测策略。中国肝炎防治基金会组织国内有关专家,参考国内外相关指南,并结合当前研究进展和临床实践经验共同讨论后达成一致意见,旨在为规范开展慢性乙型肝炎病毒感染者肝细胞癌的筛查和监测提供参考,进而改善我国肝细胞癌的防控效果和患者预后。. | zh-cn |
pair_34814388 | The disease burden of hepatocellular carcinoma in our country is serious, and the prognosis is not ideal. Therefore, early screening of high-risk groups of hepatocellular carcinoma through simple methods is the key to achieving early diagnosis and treatment and improving survival. At present, alpha fetoprotein (AFP) an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 我国原发性肝癌(肝癌)疾病负担严重,预后不理想。通过简便的方法对肝癌高危人群进行早期筛查,是实现早期诊断和早期治疗,提高肝癌生存率的关键。目前在肝癌的早期筛查方面,甲胎蛋白等血液学检查仍是主要手段,但是其灵敏度及特异度有限,存在高漏诊风险。近年来随着科学技术的不断发展,对传统检测方法的改进以及新兴标志物如甲基化DNA、微小RNA等的出现,为进一步提高早期肝癌筛查的灵敏度和特异度带来了希望。此专家共识总结了传统及新型血液学检查手段的研究进展,并提出了在肝癌早期筛查中应用的专家指导意见,旨在为肝癌早期筛查中血液学检查的应用提供依据,改善我国肝癌防控水平。. | zh-cn |
pair_34814389 | With the development of anti-HBV and HCV therapy, experts in related fields organized by the Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association updated 'Experts Consensus on Antiviral Therapy for HBV/ HCV-related Hepatocellular Carcinoma' . On the basis of previous expert recommendatio... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着抗HBV、HCV治疗学的进展,中华医学会肝病学分会肝癌学组组织相关领域专家对《HBV/HCV相关肝细胞癌抗病毒治疗专家共识》进行了更新。此版共识在以往专家建议/共识基础上,对近年新证据结果进行分析并形成相关推荐意见,以期为肝病专科、感染科以及这些科室以外从事与肝癌诊疗工作相关的临床医生及社区服务中心、基层医疗机构等相关工作人员提供指导和参考。. | zh-cn |
pair_34814402 | Gilbert's syndrome is a kind of benign inherited disease of bilirubin binding disorder, mainly due to the homozygous polymorphism A(TA)7TAA in the promoter of the gene for uridine diphosphate -glucuronosyltransferase 1A1 (UGT1A1), which is a TA insertion into the promoter, designated as UGT1A1*28, with UGT activity red... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 吉尔伯特综合征是一种胆红素结合障碍的良性遗传性疾病。主要是由于尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)基因启动子中的纯合多态性A(TA)7TAA插入启动子UGT1A1*28中,使UGT活性降低至正常值的30%,不能将循环中的脂溶性间接胆红素转化为水溶性的结合胆红素,导致高间接胆红素血症。胆红素对红细胞膜磷脂有很强的亲和力,并且可以干扰膜的组成和动力学,使红细胞的脆性增加,容易破裂,存活时间逐渐缩短,但没有明显溶血或铁代谢异常的迹象,红细胞和骨髓形态保持正常。慢性少量的溶血,可能刺激髓外(骨髓形态保持正常)造血活跃,代偿性增加循环中红细胞和血红蛋白的量;高胆红素血症也有可能减弱胃肠动力,增加肠黏膜的跨上皮被动扩散吸收胆红素,使... | zh-cn |
pair_34814403 | Patients with liver cirrhosis are prone to infection due to various reasons such as weakened immunity and intestinal bacteria translocation. Among them, bacterial infections are the most common and are the main cause for liver failure progression, leading to increased mortality, while fungal infections, mainly caused b... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝硬化患者由于机体免疫力低下、肠道细菌移位等多种原因,很容易诱发感染。其中,细菌感染最常见,是进展为肝功能衰竭、导致病死率增加的主要原因;而真菌感染,主要由假丝酵母菌(念珠菌)引起,通常与诊断延误有关。高度警惕、及时诊断和治疗感染是提高终末期肝病患者救治率的重要手段。现重点介绍肝硬化患者细菌和真菌感染的主要特点和处理方法。. | zh-cn |
pair_34814404 | Molecular targeted drugs are the first choice for systemic treatment of liver cancer. In the past decade, several anti-liver cancer targeted drugs have been launched. More recently, immunotherapy has become a dazzling nova in the field of systemic treatment of liver cancer. Nivolumab and pembrolizumab have been approve... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 分子靶向药物是肝癌系统治疗的首选方法,在过去的10年里,已有数种抗肝癌靶向药物问世。近年来,免疫治疗成为肝癌全身治疗领域一颗耀眼的新星,先后有纳武单克隆抗体和帕博利珠单克隆抗体获批二线治疗索拉非尼经治的晚期肝细胞癌患者。但是,晚期肝癌单药物治疗效果总是差强人意,越来越多的证据显示肝癌的分子靶向药物具有重要的免疫调节作用,已有数种靶向联合免疫治疗方式显示了不错的临床效果。现将肝癌领域几种分子靶向药物的免疫调节作用进行综述。. | zh-cn |
pair_34814405 | Hepatitis B virus (HBV) is an important pathogen that causes different liver diseases such as viral hepatitis and liver cirrhosis. HBV pregenomic RNA (pgRNA) plays a crucial role in HBV life cycle, which is not only the translation template of core (C) and polymerase (P), but also the template of reverse transcription.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 乙型肝炎病毒(HBV)是导致肝炎、肝硬化等肝脏疾病的重要病原体。HBV前基因组RNA(pgRNA)在其生命周期中发挥着重要作用,它既是翻译病毒核心蛋白和聚合酶蛋白(polymerase,P)的信使RNA,也是病毒进行逆转录的模板。作为HBV的重要结构蛋白,P蛋白和core蛋白的比例在HBV复制中受到严格调控。由于二者均由pgRNA翻译产生,且P蛋白的开放阅读框(ORF)位于核心蛋白ORF的下游,P蛋白的翻译如何启动是一个十分关键的科学问题。既往研究认为,P蛋白可能通过泄露扫描、翻译再起始等机制来启动翻译。本文通过文献阅读与推演,对HBV pgRNA选择性翻译P蛋白的机制进展进行综述,并尝试总结了起始P蛋白翻译的可能机制。. | zh-cn |
pair_34814431 | With the rapid changes in lifestyle, natural and social environment, the reproductive health status of couples in childbearing age continues to decline, and long-term outcomes of the rapidly increasing offspring conceived by assisted reproductive technology (ART) needs to be evaluated urgently. Therefore, the focus of ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着生活行为方式、自然和社会环境的急剧变化,育龄人口生殖健康状况持续下降,快速增加的由辅助生殖技术(ART)孕育的子代的远期健康状况亟待评估。因此,妇幼保健和生殖健康相关研究关注的重点亟需从妊娠期、围产期的死亡和严重疾病表型逐渐向全生命周期和全疾病谱拓展。为了满足这样的研究需求,在我国12个省(自治区、直辖市)启动了中国国家出生队列(China National Birth Cohort)建设,计划以家庭为单位,招募3万个自然妊娠家庭和3万个ART家庭的人群,并对夫妻双方以及孕育的子代开展长期随访,收集夫妻和子代的环境暴露、生殖生育、精神心理、行为习惯等多方面暴露数据。同时采集外周血、尿液、脐血、卵泡液和精浆、精子等多种类型的生物样... | zh-cn |
pair_34814432 | Birth cohort is an effective method to explore the relationship between various prepregnant and pregnant exposures and the health of fetuses, infants and young children. It is a long construction period to build a birth cohort and the quality of research may be affected by many factors. This paper reviews the quality a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 出生队列是研究孕前和孕期各种环境暴露因素与胎儿、婴幼儿、青少年健康之间关系的有效方法。出生队列建设周期长、环节众多,研究质量可能受到多种因素的影响。本文对中国国家出生队列建设过程中的各项质量保证和质量控制措施进行梳理,归纳总结建设经验。以期为相关队列研究提供经验,减少相关因素对队列研究的影响,提升队列研究质量。中国国家出生队列在质量保证的顶层设计方面采取一系列措施保障研究质量,包括研究中心筛选、成员管理系统开发、标准化操作流程制定及工作人员规范化培训;在质量控制方面,包括针对队列数据产生过程的实时、及时、定时质控,针对生物样本采集、处理及保存的全周期质控,以及针对参与工作人员的培训、督查和量化考核的全面立体质控。. | zh-cn |
pair_34814434 | Birth cohort is an important observational study which can continuously and dynamically collect the exposure changes and health outcomes from gametophyte development to adolescence and even old age. However, because of its complex design and difficult implementation, how to construct birth cohort with high quality and ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 大型出生队列是持续、动态地收集个体生命早期暴露信息,探讨暴露与生命远期健康结局因果关联的一种重要的队列研究类型。但由于其设计复杂、实施难度大,如何保证出生队列建设的高质量高效率是国内外流行病学研究者面临的主要挑战。2016年,国家重点研发计划资助的中国国家出生队列(China National Birth Cohort)建设正式启动。该队列在设计实施过程中,不断积累经验,充分运用网络和信息化手段,探索并建立了一套“云端信息平台”,以支撑覆盖全国16家单位的出生队列建设。经过四年的发展,该系统平台在“出生队列人群招募和随访管理、数据的实时交互、队列质量控制、多级权限管理和职能划分”等多个方面已经发展出一整套完善的建设方案。该平台的设计... | zh-cn |
pair_34814435 | Autism spectrum disorder (ASD), a representative disease of children's neurodevelopmental disorders, brings huge pressure and financial burden to families and society. It is of great significance to explore its etiology and pathogenesis. Therefore, we established an ASD Cohort based on the existing China National Birth... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 孤独症谱系障碍作为儿童神经发育障碍的代表性疾病,发病率呈现不断上升的趋势,给家庭和社会带来巨大压力和经济负担,探讨其病因及发病机制意义重大。本研究依托中国国家出生队列开展孤独症谱系障碍亚队列建设,并利用该出生队列采用的辅助生殖和自然妊娠同期纳入并随访的平行设计,评价辅助生殖技术对子代神经行为发育的影响,并结合队列采集的多种母体孕期和子代生命早期临床及行为相关信息,综合探究孤独症谱系障碍的发病危险因素。本文将从研究目标、内容、初步进展、优势与不足及进一步展望对该亚队列进行简要介绍,重点展现本研究的总体设计和现阶段进展。. | zh-cn |
pair_34814436 | The importance of gut microbes to human health has gradually attracted attention. With the use of animal models, it has been revealed that maternal microbes during pregnancy could influence their children's health outcomes through shaping their microbial composition and regulating the development of their metabolic and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肠道微生物对人类健康的重要性逐渐被人们关注。动物模型揭示了孕期母体微生物通过对子代微生物、代谢和免疫发育的作用影响了子代健康结局。然而,人体生理机制更为复杂,并受到多种暴露因素的交互影响,在动物模型中得到的研究结果往往与人群研究不一致。目前,孕期母体肠道微生物对子代微生物定植和健康的影响尚不明确。在大型前瞻性出生队列的基础上建设微生物亚队列,检测母亲孕期和子代发育多时点微生物组状态,并进一步与人群环境、行为暴露等宏观信息结合,能更好地为人体健康和疾病的机制研究提供可靠支撑。本研究从研究目标、内容、进展及优势与潜在问题等方面对该亚队列研究进行简要介绍,着重呈现本研究的总体设计和进展情况。. | zh-cn |
pair_34814454 | Antibiotic resistance (AR) is a severe and fast-growing public health challenge with rapid globalization, especially in China. Although some monitoring systems were established in different fields, fragmentation of information failed to show the overall trend and spread of AR. It is necessary to establish a national mo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 当前我国病原菌耐药性问题严重,我国在多领域已分别建立的耐药监测网络,由于监测技术方法不统一,信息碎片化,无法显示我国病原菌耐药的整体流行趋势和传播规律。因此需构建全国多领域的病原菌耐药监测网络平台,揭示我国病原菌耐药发生、发展和传播规律。监测平台中需要使用相匹配的分析指标评价体系。本研究拟探索出一套科学合理的耐药监测分析指标,适用于包括人群、畜牧养殖、环境和食品相关环节等在内的耐药性数据监测与分析。经对我国5个耐药监测网络的调查分析,结合文献及专家调研,初步构建了包含15个病原菌耐药监测分析指标的评价体系,为我国的病原菌耐药监测网络数据收集、整理、评价及预测、预警体系的构建提供基础。. | zh-cn |
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