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pair_32185882 | This study aims to investigate the association between serum creatinine and risk of type 2 diabetes mellitus (T2DM) based on a cohort analysis and meta-analysis of cohort studies. We enrolled 41 439 participants aged ≥18 years without T2DM at baseline, who had ≥2 health examinations based on an ongoing prospective coho... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_32186172 | Severe and critical coronavirus pneumonia 2019 (COVID-19) often occurs in elder patients with multiple comorbidities, and severe hypoxemia events constitute a key factor for the deterioration of some cases. The critical type of COVID-19 could progress into acute respiratory distress syndrome and multi-organ dysfunction... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 重型和危重型新型冠状病毒肺炎常常发生于高龄及多合并疾病患者,严重低氧事件是造成部分病例病情恶化的重要因素。危重型可进展为急性呼吸窘迫综合征及多器官功能障碍,是造成死亡的重要原因。针对可能的病生理异常,及早开始无创通气治疗有助于改善预后。严密监护氧合情况、降低患者氧耗量、积极心理干预、迅速处理低氧事件是无创通气成功治疗的关键因素。积极纠正凝血功能紊乱、合理的营养支持、准确的容量控制和安全个体化的血糖监控等治疗具有重要意义。. | zh-cn |
pair_32187410 | To identify trends in global health competency improvement programs for nurses and to verify their effects. Systematic review and meta-analysis. Articles published from 2000-2017 in Ovid MEDLINE, Embase, and ProQuest and the Cumulative Index to Nursing and Allied Health Literature database, Cochrane Library, Research I... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 了解全球健康能力提升计划对护士的影响趋势,并检验其影响力。 设计: 系统综述与荟萃分析。 数据来源: 在Ovid MEDLINE联机医学文献分析和检索系统、Embase荷兰医学文摘数据和ProQuest学位论文管理系统和护理学及医疗相关文献累计索引数据库、考克兰图书馆、研究信息共享服务平台、学术期刊信息数据库、韩国研究信息服务系统和国会图书馆中于2000年至2017年期间发表的文章。 审查方法: 采用Cochrane系统评价方法进行系统综述、荟萃分析和敏感性分析。 结果: 对19个研究项目进行评价。其中,12个研究项目用于荟萃分析。据荟萃分析的显示,全球健康能力提升计划会影响多元文化的自我效能和文化能力。 结论: 本研究的发... | zh-cn |
pair_32187708 | To identify and evaluate the available evidence on the effectiveness of character strengths-based intervention on the psychological well-being of patients with chronic illnesses. A systematic review with meta-analysis. Six electronic databases, including PubMed, EMBASE, EBSCO (CINAHL<sup>®</sup> and MEDLINE), Web of Sc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 通过对慢性病患者心理健康状况的调查,确定并评价基于性格优势的介入治疗的效果。 设计: 采用荟萃分析进行系统综述。 数据来源: 搜索包括PubMed因特网生物医学信息检索系统、EMBASE荷兰医学文摘数据、EBSCO文献数据库(CINAHL®护理学数据库和MEDLINE联机医学文献分析和检索系统)、Web of Science科研数据库平台和PsycINFO心理学文摘数据库在内的6个电子数据库从开始到2018年12月的文章。 审查方法: 根据乔安娜布里格斯研究所严格评价检查表和系统综述和荟萃分析优先报告的条目的标准指南,进行证据质量评估和研究总结。根据Cochrane系统评价采用RevMan 5.1进行荟萃分析。 结果: 对慢... | zh-cn |
pair_32187917 | Reports a case of diabetic foot patient with right toe pain, ulceration for 4 years and aggravation for 1 month. After rigorous medical treatment and related examinations, transeversal bone transfer of tibia was proposed. However, the skin condition on the inner side of the lower leg was not good before the operation, ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 报道1例出现右足趾肿痛、破溃4年,加重1个月的糖尿病足患者,经严格内科治疗及相关检查后,拟行胫骨横向骨搬移,但术前发现小腿内侧皮肤条件欠佳,遂行腓骨横向骨搬移。用微型截骨器在腓骨外侧中段两侧截骨,两截骨线相距约10 cm,远端截骨线距外踝尖约10 cm。术后第8天开始骨搬移,每6小时搬移1次,每天向内侧延长1 mm,搬移14 d后再往回搬移14 d。从术前术后皮温、踝肱指数、CT血管造影、CT值、疼痛视觉模拟评分(VAS)及创面愈合情况等进行对比评估。术后28 d创面完全愈合。. | zh-cn |
pair_32187919 | Image-guided percutaneous placement of breast tissue marker clip (breast marker) is mainly used for precisely marking and localizing breast cancer lesion and metastatic axillary lymph node. Until now, there is no clinical guideline in the field worldwide. This consensus established by Chinese Society of Breast Surgery,... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 影像学技术引导的可视化经皮穿刺乳腺组织定位标记夹(乳腺Marker)置入,主要用于乳腺癌病灶及腋窝转移淋巴结的精准标记定位,迄今国内外尚缺乏临床应用指南可循。中华医学会外科学分会乳腺外科学组基于临床实践总结和文献复习,对乳腺Marker的临床应用指征、关键置入操作流程与评估、并发症预防与处理等提出建议,以期推动乳腺Marker的安全和规范应用。. | zh-cn |
pair_32187921 | The 2019 coronavirus disease(COVID-19) has cost a great loss to the health and economic property of Chines people. Under such a special circumstance, how to deal with such patients with acute aortic syndrome has become a serious challenge. Rapid diagnosis of concomitant COVID-19, safe and effective transportation, impl... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 新型冠状病毒肺炎对我国人民的生命健康和经济财产造成了巨大的损失。在这样的特殊形势下,如何应对主动脉急症患者成为一个严峻的挑战。快速诊断患者是否合并新型冠状病毒肺炎、安全有效地转运患者、实施合并肺炎患者的介入手术、保护血管外科医疗团队,以及对患者的术后管理和随访等,都成为血管外科医师亟待解决的问题。结合最新的国家政策、文献报道和个人所在单位支援武汉的防控经验,本文对上述问题进行了简要阐述,希望引发全国血管外科医师对新型冠状病毒肺炎疫情下如何实施血管外科危重急症乃至常规血管疾病诊疗的思考,共同应对疫情,并在最大程度上将疫情的损害降至最低。. | zh-cn |
pair_32187922 | The cirrhotic portal hypertension is very common worldwide and poses a serious threat to the health of patients.Over past three decades, the surgical treatment for cirrhotic portal hypertension was strongly challenged by the drugs, endoscopy, interventional therapy and liver transplantation.However, under the multidisc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝硬化门静脉高压症在全球均十分常见,严重危害患者生命。近三十余年来,药物、内镜、介入及肝移植等治疗方法的兴起与临床广泛应用,使传统的门静脉高压症的外科治疗面临前所未有的严峻挑战。尽管如此,在现今多学科协作(MDT)诊疗模式中,外科手术仍发挥着不可替代的作用。腹腔镜下贲门周围血管离断术因具有手术损伤小、出血量少、术后恢复快、并发症发生率低、疗效确切等优点,得到了较好推广。应强调在MDT诊疗模式下重视新方法、新技术与新理念的开展与应用,充分发挥各学科优势,对门静脉高压症患者实施规范化、个体化与精准化治疗,使患者的临床获益最大化。. | zh-cn |
pair_32187929 | The outbreak of pneumonia caused by the novel coronavirus (2019-nCoV) in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China's public health and clinical treatment. The virus belongs to the β genus Coronavirus in the family Corornaviridae, and is closely related to SARS-CoV and MERS... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019年岁末,在武汉暴发新型冠状病毒(2019-nCoV)引起的肺炎流行,给我国公共卫生和临床救治带来巨大挑战。2019-nCoV属于冠状病毒科β冠状病毒属,与严重急性呼吸综合征相关冠状病毒(SARS-CoV)和中东呼吸综合征相关冠状病毒(MERS-CoV)近缘,都会导致严重肺炎症状。该病毒经飞沫、接触等途径传播,潜伏期患者即具备传播性。目前数据表明:2019-nCoV比SARS-CoV毒力弱,但传播力强;造成其能够跨种传播的受体可能与SARS-CoV一致,都是血管紧张素转化酶Ⅱ(ACE2)。在此疾病暴发后,我国科技人员投入大量精力开展研究,快速开发出诊断试剂,初步确定了病原特性,并已筛选出可能抑制该病毒的临床药物,也正在加快研发... | zh-cn |
pair_32187930 | The safety of prophylactic vaccine is one of the key points both in clinical trials and evaluation. Based on the review practice of vaccine registration clinical trials in recent years, we puts forward a series of thoughts and suggestions on the common problems of safety study on vaccine, including the hypothesis of sa... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 预防用疫苗(疫苗)的安全性是临床试验重点关注和评价的内容之一。本文结合近年来疫苗注册试验的审评实践,就安全性研究的常见问题提出系列思考和建议,包括安全性研究假设,入排标准及暂停/终止标准的考虑,安全性观察的常规要求和临床指标、疫苗排毒及佐剂安全性等特殊研究内容,并进一步明确了序贯入组的安全性观察要求,强调了因果相关性的科学判定和安全性监测工作质量等方面内容,供疫苗研发参考和借鉴,同时探讨适宜的解决方法,以促进我国疫苗研发和风险控制。. | zh-cn |
pair_32187931 | The safety of prophylactic vaccine is one of the key points both in clinical trials and evaluation. Based on the review practice of vaccine registration clinical trials in recent years, we summarized the common problems in safety analysis and report and accordingly puts forward a series of thoughts and suggestions, inc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 预防用疫苗(疫苗)的安全性是临床试验重点关注和评价的内容之一。本文结合近年来疫苗注册试验的审评实践,汇总了安全性分析和报告中的常见问题并相应提出系列思考和建议,包括探讨了安全性分析中统计学的作用,提出了安全性分析和报告的框架,涉及分析内容、分析指标和分析维度,其中关注了严重程度的分析;强调安全性风险信号应主动分析,鼓励基于循证的要求开展安全性评价;同时就说明书中收载安全性研究信息的基本原则、以及各期试验及不同受试者安全性数据综合考虑的问题进行了探讨,供疫苗注册申请人参考和借鉴,以促进我国疫苗临床研发和评价。. | zh-cn |
pair_32187939 | From November to December of 2018, twenty 65-year-old or older women patients with knee osteoarthritis were recruited from the Department of Physical Therapy, the First Affiliated Hospital of Anhui Medical University. Meanwhile, twenty healthy 65-year-old or older women were recruited from the local community. The resu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 于2018年11—12月在安徽医科大学第一附属医院康复科招募≥65岁女性膝骨关节炎患者。同期在社区招募≥65岁健康女性,各20名。检测结果显示,膝骨关节炎组在行走触地时,膝关节的触地角度更屈曲(<i>P=</i>0.040),在支撑期膝关节的最小角度会增加(<i>P=</i>0.008);髋和踝关节在支撑期的最大屈曲角度与对照组差异无统计学意义(<i>P></i>0.05)。在支撑期,膝骨关节炎组胫骨前肌积分肌电低于对照组(<i>P=</i>0.023)。膝骨关节炎会改变老年女性的步态以及肌电活动表现,尤对下肢膝关节的影响最大。. | zh-cn |
pair_32187940 | To conduct outbreak identification and transmission factor analysis of typhoid epidemic occurred in Xinqiao town, Jiangyin city from June to September 2016. A total of 14 strains of Salmonella typhi isolated from confirmed cases were collected, and 65 external environment samples and 13 food samples related to the outb... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 针对一起于2016年6—9月发生在江阴市新桥镇的伤寒疫情开展暴发确认和传播因素分析。首先收集分离自确诊病例的14株伤寒沙门菌;再采集与疫情相关的外环境样本65份和食品样本13份,运用实时荧光PCR法检测样本中伤寒沙门菌特异基因,采用常规分离培养法分离伤寒沙门菌。对所有伤寒沙门菌分离株进行药敏试验及脉冲场凝胶电泳(PFGE)分析。从外环境样本(K熟食店加工厂井水)中分离得到1株伤寒沙门菌。15株伤寒沙门菌均对萘啶酸耐药,经脉冲场凝胶电泳后共获得2种带型,其中13株病例分离株和环境分离株的PFGE指纹图谱完全一致,另外1株病例分离株的PFGE带型存在1个条带的差异。结合流行病学调查和实验室检测结果,判定本次暴发疫情是由同一伤寒沙门菌遗传... | zh-cn |
pair_32187941 | In recent years, the high infection rate of Helicobacter pylori and its impact on cardiovascular disease have attracted public attention. It may directly affect coronary heart disease, stroke, etc. through various mechanisms such as inflammation, immune response, and damage to endothelial cells. It could also play an i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年来,幽门螺杆菌的高感染率及其对心血管疾病的影响引发了人们的关注,其可能通过炎症反应、免疫反应和损伤内皮细胞等多种机制直接参与冠心病、脑卒中等心血管疾病的发生发展,同时也可在动脉粥样硬化、高血压、高同型半胱氨酸血症和血脂异常等心血管疾病危险因素的形成中发挥重要作用。但目前国内外研究结果尚不一致,仍需要通过大量实验进一步确证,以采取有效措施控制心血管疾病的发生率。本文现就幽门螺杆菌与心血管疾病的流行情况、国内外研究现状及其相互作用机制进行综述。. | zh-cn |
pair_32187942 | Thallium is a highly toxic heavy metal. The adverse maternal and infant health effects caused by thallium exposure during pregnancy have also attracted more and more scholars' attention. This study focused on the sources of thallium exposure and its influencing factors, the association between thallium exposure during ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 铊是一种剧毒重金属,孕期铊暴露引起的不良母婴健康效应也得到了越来越多的学者关注。本研究从铊暴露的来源及其影响因素、孕期铊暴露与妊娠并发症及新生儿不良出生结局的关联、孕期铊暴露对儿童出生后生长发育的影响以及孕期铊暴露引起不良母婴健康效应的潜在机制等方面,综述了相关研究进展,可为深入研究孕期铊暴露的危害、预防和控制提供新的依据。. | zh-cn |
pair_32187943 | On the occasion of the 70(th) anniversary of the founding of Chinese Journal of Ophthalmology, we review the establishment and development of Chinese Association for Pediatric Ophthalmology and Strabismus (CAPOS) and the major advances in the diagnosis and treatment of pediatric eye diseases in China since 1949, so as ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 时值《中华眼科杂志》创刊70周年之际,回顾我国斜视与小儿眼科专业的学科发展和建设历程、专业诊疗技术进展历程,一方面再现新中国斜视与小儿眼科专业诊疗技术方面所取得的辉煌成绩,同时也为国内斜视与小儿眼科专业同道今后的临床和科研工作提供参考,并以此缅怀前辈,激励后人,为中国眼科事业发展砥砺前行!(中华眼科杂志,<i>2020</i>,<i>56</i>:<i>161</i>-<i>165</i>). | zh-cn |
pair_32187944 | There are many pathogenic factors of strabismus. In addition to the changes of alignment and ocular movement, there may be abnormal pathways and development of extraocular muscles, abnormalities of orbital and intraorbital connective tissue, paralysis of cranial nerves (oculomotor nerve, trochlear nerve, and abductor n... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 斜视的发病因素诸多,除了眼位和眼球运动发生改变外,可能同时存在眼外肌走行和发育异常、眼眶和眶内结缔组织异常以及颅神经(动眼神经、滑车神经、展神经)麻痹或核性和核上性病变,或伴有其他颅脑发育异常等。近年来影像学技术不断进步,影像学图像因可清晰显示斜视患者眼部、眶部、眼外肌及其支配神经的改变,临床多用于明确斜视及眼外肌相关疾病的病因,为斜视的诊断和治疗提供依据。本文通过阐述MRI在斜视检查中的价值和重要性、CT在非共同性斜视检查中的意义、眼球运动障碍相关的头颅MRI基本特征,指出斜视专业医师应重视影像学检查的应用,做到深入学习,精准治疗,从而提高临床斜视的诊断和治疗水平。(中华眼科杂志,<i>2020</i>,<i>56</i>:<i>... | zh-cn |
pair_32187945 | Horizontal strabismus, the most common type of strabismus, can be complicated by the disorder of inferior oblique muscle or superior oblique muscle. It may cause problems such as compensatory head posture, vertical diplopia, torsional diplopia, and abnormal binocular fusion. In horizontal strabismus cases, the disorder... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 水平性斜视是斜视中最常见的类型,可伴发上、下斜肌功能异常以及A-V型斜视,并可能由此引发代偿头位、垂直性复视、旋转性复视、双眼融合功能异常等问题,故在水平性斜视的诊治过程中应避免遗漏斜肌异常,避免因斜肌手术指征把握不准而导致治疗不当。本文从注意发现水平性斜视伴发的下斜肌功能亢进、正确掌握水平性斜视伴发上斜肌功能异常的诊疗原则、识别A-V型斜视相关疾病等方面进行阐述,指出临床应正确认识水平性斜视伴发的斜肌异常问题,采取恰当的手术方式,在矫正水平性斜视的同时正确治疗斜肌异常,以期治疗后获得最佳眼位及双眼视功能。(中华眼科杂志,<i>2020</i>,<i>56</i>:<i>171</i>-<i>175</i>). | zh-cn |
pair_32187952 | Intermittent exotropia is a common form of childhood strabismus, which is mainly treated by surgery. However, there are still controversies about the natural course of the disease, the assessment of the disease severity, the choice of the surgery time, the determination of the target eye position and the choice of the ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 间歇性外斜视是一种常见眼病,临床以手术治疗为主。但是,针对间歇性外斜视的自然病程、病情严重程度的评估、手术时机的选择和目标眼位的确定以及治疗方法的选择等问题还存在争议。本文对间歇性外斜视的临床研究进展作一综述,希冀为间歇性外斜视的早期发现、科学诊断和规范治疗提供依据。(中华眼科杂志,<i>2020</i>,<i>56</i>:<i>231</i>-<i>234</i>). | zh-cn |
pair_32189345 | To explore voluntary immigrant parents' experiences of child healthcare services in host countries. Thomas and Harden's qualitative thematic synthesis method. Five electronic databases (CINAHL, Medline, PubMed, Psych INFO and Web of Science), were systematically searched from January 2000 - October 2018. Included studi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨自愿移民的父母在移民接受国经历的儿童保健服务。 设计: 托马斯和哈登的定性主题综合法。 数据来源: 对5个电子数据库在2000年1月至2018年10月期间的内容进行系统性的检索(CINAHL护理学数据库、Medline联机医学文献分析和检索系统、PubMed因特网生物医学信息检索系统、Psych INFO心理学文摘数据库和Web of Science科研数据库平台)。 审查方法: 纳入侧重自愿移居/移民父母经历的儿童保健服务的研究。由两位作者独立提取数据。应用文献严格评价项目工具和使用定性主题综合法。 发现: 9个研究项目符合纳入标准。确定了五个描述性主题:(a)寻求信息和宽慰,(b)向“同经历的人”寻求信息,(c)原籍... | zh-cn |
pair_32189368 | To establish an understanding of the experiences of newly qualified nurses' working in hospices from the perspective of both newly qualified and senior nurses. A qualitative interview study. Semi-structured interviews with six newly qualified nurses and five senior nurses from four UK hospices were conducted between Ma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 从新合格护士和老护士的角度处罚,了解新护士在医院中的工作经历。 设计: 访谈式的定性研究。 方法: 在2017年3月至7月间,对来自英国4家医院的6名新合格护士和5名老护士进行半结构式的访谈。 结果: 参与本研究的临终关怀机构是最早招募新合格护士的机构之一。受访者认为,新合格护士能很好地应对临终关怀工作,取得独特的职业发展机会。受访者确认了正式和非正式支持的价值,不过,新合格护士会面临来自一些老员工的负面的态度。新合格护士表达了缺少技术临床技能培训的顾虑。然而,他们强调指出其收获了临终关怀和沟通技能,而这些技能可以转用于其他的环境。受访者还强调,最好在教育和正式的支持,包括指导在内,分配更多的时间。老职员并不一定期望新合格护... | zh-cn |
pair_32189370 | The aims of this study were to develop an understanding of the lived experience of the Post Anaesthetic Unit Recovery Nurse facilitating Advanced Directives and implications for patient-centred care. Interpretive phenomenological analysis. Homogenized purposive sampling of six Registered Nurses using in-depth semi-stru... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 本研究的目的是了解麻醉恢复室护士在推进预立医疗指示的真实经历以及以患者为中心的护理启示。 设计: 解释现象的分析方法。 方法: 采用半结构式访谈的方式对6名注册护士进行相似的立意抽样。访谈时间为2018年6月至7月。并采用解释现象的分析方法。 结果: 麻醉恢复室护士在推进麻醉后预立医疗指示时会经历一个“灰色地带”。这个“灰色地带”的定义分为四个主题:以生理不稳定为特征的麻醉的“触发”;平衡医生和患者麻醉后主张者之间角色的“困惑和挫败”;医务人员在考虑预立医疗指示时的“一贯的家长式作风”;护士面对主张、个人苦恼、缺失书面内容或协议、信息交接等问题的“去权”。 结论: 护士在推动麻醉后预立医疗指示的真实经验可能充满沮丧感。需要进... | zh-cn |
pair_32189374 | Amphibian populations globally are in decline. One great threat is the abstraction of water resources that alter surface-water hydrology. Conservation actions aimed at restoring or manipulating surface water are employed as a management tool, but empirical evidence on the effectiveness of these approaches is scarce. In... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 全球两栖动物的数量正在下降。一个巨大的威胁是水资源开发, 这改变了地表水文。旨在恢复或控制地表水的保护行动已被用作一种管理工具, 但是相关方法有效性的经验证据尚且很少。在这篇综述中, 我们总结了全球利用水资源保护两栖动物的经验。我们探索了利用水资源保护两栖动物物种及群落的例子。各种方法的实施频率和成功与否各不相同。延长水文周期以适应幼虫需求的方法, 以及在非生产季节干燥土壤以控制捕食者的方法, 都获得了喜人的成果;向环境中喷水也表现出潜在应用价值, 但成功的例子还很有限。尽管采取了一些有前景的干预措施, 但我们只确定了少数成功控制水资源使两栖动物受益的经验支持的例子 (n = 17) 。目前还不清楚这是否源于文献发表偏倚或是对论文语... | zh-cn |
pair_32189374 | Amphibian populations globally are in decline. One great threat is the abstraction of water resources that alter surface-water hydrology. Conservation actions aimed at restoring or manipulating surface water are employed as a management tool, but empirical evidence on the effectiveness of these approaches is scarce. In... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Manipulación del Agua para la Conservación de Anfibios Resumen Las poblaciones mundiales de anfibios están en declinación. Una gran amenaza es la extracción de los recursos hídricos que alteran la hidrología superficial. Las acciones de conservación enfocadas en la restauración o manipulación del agua superficial se em... | es |
pair_32190928 | To identify activities performed by Nursing Assistants in acute and primary healthcare. Systematic review. The databases MedLine/PubMed, ProQuest and Google Scholar were searched for empirical studies published in the English language between 2008 and 2018 that addressed the work of Nursing Assistants. From an initial ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 了解助理护士在急性护理和初级保健领域所开展的活动。 设计: 系统综述。 数据来源: 在MedLine联机医学文献分析和检索系统/PubMed文献服务检索系统、ProQuest学位论文管理系统和Google Scholar谷歌学术搜索数据库中搜索2008年至2018年期间发表的涉及助理护理工作的英语类实证研究。 审查方法: 从最初的2944份发表文章中,保留了71份发表文章进行全文审查,最后选择出20份发表文章纳入本次的评价研究。从中摘取出8个国家助理护理所开展的活动,并划分六大类。 结果: 在全球范围内,指派被助理护士的活动识别出200多个。其中许多活动超出了助理护士的培训范畴,需要在注册护士有限的监督下进行。 结论: 他们... | zh-cn |
pair_32192294 | In December 2019, a new outbreak of corona virus disease 2019 began to occur. Its pathogen is 2019-nCoV, which has the characteristics of strong infectivity and general susceptibility. The current situation of prevention and control of new coronavirus pneumonia is severe. In this context, as front-line medical workers ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019年12月,新型冠状病毒肺炎开始暴发流行,其病原体为2019-nCoV,具有感染力强,人群普遍易感的特点。目前新型冠状病毒肺炎的防控形势严峻。在这样的背景下,作为一线的医务工作者肩负着重要的责任和压力,但是通过我们严格的管理策略,可以尽可能地减少感染暴露的风险。笔者通过对近几年的研究进展和指南的归纳总结,从结直肠癌的疾病筛查、治疗策略(包括早期结直肠癌、局部晚期结直肠癌、梗阻性结直肠癌、转移性结直肠癌以及新辅助治疗后患者的治疗)、辅助治疗的药物选择和时限选择、急诊手术患者的防护措施、术后患者复查以及医务人员的防护等方面,进行了治疗策略的改进,以期在新型冠状病毒肺炎疫情严峻的形势下,为广大患者提供更多的选择,以获得最佳的治疗,也... | zh-cn |
pair_32192295 | Pneumonia caused by 2019-nCoV infection has been reported in Wuhan since December 2019, and spread rapidly across the country. The radical operation of colorectal cancer is semi-elective operation. Patients with colorectal cancer should receive operation as soon as possible after elective operation is resumed in each h... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 自2019年12月以来,新型冠状病毒肺炎(新冠肺炎)在武汉暴发,并迅速向全国蔓延。新冠肺炎病毒可经由无症状感染者传播,并已被证实可经飞沫传播与接触传播,但粪口传播和气溶胶传播尚未除外。结直肠癌患者根治性手术属限期性手术,笔者根据本中心近期开展腹腔镜结直肠癌手术的经验,提出在新冠肺炎疫情条件下结直肠癌患者的手术策略。包括术前严格执行筛选流程、以减少后期院内传染风险;推荐对结直肠癌患者根治性手术采用腹腔镜辅助手术的方式进行治疗;严格进行术中气溶胶管理;慎重开展经自然腔道取标本手术和经肛全直肠系膜切除术;科学、合理进行预防性造口和严格切实加强病房及手术室人员防护。. | zh-cn |
pair_32192296 | Corona virus disease 2019 (COVID-19) is currently raging in China. It has been proven that COVID-19 can be transmitted from human to human and cause hospital infection, which seriously threatens surgical staffs and inpatients. Although colorectal surgery is not a front-line subject in the fight against the epidemic, bu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 新型冠状病毒肺炎(新冠肺炎)目前正在我国肆虐。已经证实,新冠肺炎存在明显的院内感染现象,给外科医护人员和住院患者造成严重威胁。虽然结直肠外科并不是此次抗击疫情的一线学科,但在特殊的形式下,如何最大限度地在保护患者、家属、医务工作者自身的健康以及病区和医院医疗安全的前提下,为患者提供最优质的医疗服务,保证以往临床工作的有序开展,是当下的艰巨任务。笔者参照我国《新型冠状病毒感染的肺炎诊疗方案》,结合《上海仁济医院新型冠状病毒文件汇总》的实际工作情况,总结了新冠肺炎疫情防控形势下,如何开展结直肠外科临床工作,分享了如何在疫情防控情况下,针对结直肠肿瘤急诊患者的诊疗流程、对结直肠肿瘤的诊断和准备择期入院手术结直肠癌患者的处理、病房的防护、围... | zh-cn |
pair_32192297 | The outbreak of corona virus disease 2019 (COVID-19) makes the medical treatment of colorectal cancers difficult. Cancer patients are more susceptible to infection and tumor history is defined as an important factor of poor prognosis, which challenges both doctors and patients. For metastatic colorectal cancer (CRC) pa... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 新型冠状病毒肺炎疫情的爆发给结直肠癌的治疗带来了困难。肿瘤患者作为感染的高危人群,肿瘤病史作为新冠肺炎不良预后的重要因素,都是当下医患双方共同面临的挑战。对于复发转移性结直肠癌患者,低强度的维持治疗是更好的选择,病情变化或恶性度较高的肿瘤患者仍需接受联合化疗。对于根治术后的患者,鉴于辅助化疗获益程度的相对有限,可降低治疗强度并减少治疗时间。面对发热的肿瘤化疗患者,需要对患者的发热原因进行分析,按国家《新型冠状病毒感染的肺炎诊疗方案(试行第六版)》文件规定的流程接受排查。病情稳定、一般状况良好及治疗有效的患者可择期推迟影像学评估的时间。临床医师应根据每例患者的具体情况作出个体化的临床决策。. | zh-cn |
pair_32192298 | As an emerging treatment method, watch and wait (W&W) strategy is not the standard treatment for rectal cancer patients but recommended by some guidelines. The legal risk of W&W is that once the medical behavior fails to achieve the desired effect, the patient may think that it is because of the wrong choice of treatme... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 直肠癌新辅助治疗后等待观察策略(W&W)作为新兴的治疗方法,目前并非直肠癌患者标准治疗方案,但已被部分指南接受。开展W&W的法律风险在于,一旦医疗行为未达到预期效果,患方可能认为是由于医方治疗方案的选择错误,延误其接受直肠癌根治性切除术,从而引发医疗争议。对于上述法律风险,开展直肠癌新辅助治疗后W&W策略时,医务人员应尽到更高的责任义务,包括确认该治疗方法具备相对可靠的循证医学证据、充分履行告知义务并取得患方知情同意、制定标准化的诊疗程序以确保诊疗行为的规范性。同时,通过患者教育及沟通,使患者知悉、配合医务人员为改善患者结局及生活质量所做的努力,了解接受此治疗策略可能的获益及风险,以及接受常规治疗的疗效及损害,以共同做出治疗选择。. | zh-cn |
pair_32192299 | The comprehensive treatment of solid tumor has become a mature treatment model. Under this model, many tumors, such as breast cancer, anal squamous cell carcinoma, rectal gastrointestinal stromal tumor and rectal cancer, are undergoing the evolutionary process of reducing the extent of surgery and witnessing an increas... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 实体瘤的综合治疗业已成为成熟的治疗模式。在此模式下,诸多肿瘤如乳腺癌、肛管鳞癌、直肠胃肠间质瘤、直肠癌等都在经历手术范围缩小、器官保留需求增加的演变过程。直肠癌新辅助放化疗(nCRT)后等待观察(W&W)是近年关注的热点话题。现有资料显示,对临床完全缓解(cCR)或预期有可能达到病理学完全缓解(pCR)的患者,采用W&W的策略多可获得与手术相近的肿瘤学结局,但生活质量显著改善。从肿瘤外科沿革的历程看,对直肠癌nCRT后W&W策略的获益人群筛选、方法改进、评估优化、风险防控等需要深入研究。鼓励医患共同决策、充分沟通及知情同意、谨慎开展临床研究及实践、积累高级别循证医学证据等,对推动此项工作至关重要。'主动性等待观察'理念的提出将有助于... | zh-cn |
pair_32192300 | In 2004, Habr-Gama reported a new group of rectal cancer patients achieving clinical complete response (cCR) after neoadjuvant chemoradiotherapy, who were able to get a satisfactory curative effect after a non-operative watch and wait (W&W) strategy. Since then, W&W has attracted more and more public attention. Althoug... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Habr-Gama于2004年率先报道了一组新辅助放化疗后达到临床完全缓解(cCR)直肠癌患者在进行非手术的等待观察(W&W)后,获得满意的疗效。自此,W&W走入人们视线并日益受到关注。虽然越来越多的临床研究结果表明,W&W策略对部分直肠癌患者安全可行,但目前仍然缺乏足够的循证医学证据。因此,对该方案的实施及安全性仍然受到质疑。主要的焦点在于什么是最优化的放化疗方案;cCR的判断时间及判断标准;目前仍然缺乏更精准的手段对cCR进行准确的预测和评估;对局部肿瘤再生后补救手术的实施方案及其安全性;肿瘤远处转移的风险是否会增加;目前尚缺乏患者长期的肿瘤学及功能学随访结果。本文将根据文献并结合本中心的经验,对目前W&W开展现状及存在问题加以... | zh-cn |
pair_32192301 | Watch and wait (W&W) after neoadjuvant treatment of rectal cancer has been a focus in the field of rectal cancer in recent years. Many Chinese or international centers have accumulated valuable experience through conducting clinical research, but there are many disputes about the details of developing W&W, and there is... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 直肠癌新辅助治疗后'等待观察'策略(W&W)是近年直肠癌领域的焦点问题,国内外各医疗中心通过开展临床研究,已积累了宝贵经验;但对于开展W&W的细节存在着诸多争议,也存在着证据级别不足的问题。数十位编审专家集思广益,分享了开展W&W的经验,共同编写了《直肠癌新辅助治疗后等待观察策略共识(2020版)》(《共识》)。本文就《共识》中易引起困惑的五个问题,即近临床完全缓解(near-cCR)与延长等待时间、临床完全缓解与病理学完全缓解的关系、活检在W&W中的作用、局部切除术以及接触性X线近距离治疗做进一步的分析和解读,同时阐述《共识》中根据国情做出的调整。. | zh-cn |
pair_32192302 | After neoadjuvant chemoradiotherapy(nCRT), 15%-40% of rectal cnacers has a pathological complete response (pCR), with non-malignant cells demonstrated in histological assessment of the surgical resection specimen. Since these patients have excellent oncological outcomes, there has been a rapidly growing interest in org... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 局部进展期直肠癌经新辅助治疗后,有15%~40%的患者可达到病理学完全缓解(pCR),此类患者肿瘤相关结局极好。越来越多的研究表明,此类患者有可能避免根治性切除,代之以等待观察策略。施行等待观察策略的主要挑战之一就是如何准确识别pCR患者。目前,针对临床等待观察策略中完全缓解(CR)患者的检出,主要有两种不同的影像评估方案:一是美国纪念斯隆凯物琳癌症中心(MSKCC)提出的三维度评估方案;二是Mercury提出的核磁肿瘤退缩分级(mrTRG)标准。但现有的影像学评估方法存在显着异质性,证据主要来自回顾性队列研究,且缺乏长期生存的数据。如何在术前准确地筛查pCR患者,是临床关注的重点及难点问题。. | zh-cn |
pair_32192303 | Some studies have demonstrated promising results of watch and wait (W&W) approaches in carefully selected patients with locally advanced rectal cancer who get a clinical complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT). This approach of organ- preservation helps patients avoid surgery and its related ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 研究表明,局部进展期直肠癌患者新辅助放化疗(nCRT)后,会发生临床完全缓解(cCR)。部分精心挑选的患者经等待观察后,获得很好的疗效。这种保留器官的方法,有助于患者避免手术及其相关的发病率和死亡率。nCRT会导致肿瘤细胞的退变和残留肿瘤细胞的不均匀分布。由于假阴性率高,活检的可靠性在等待观察策略中仍不尽如人意。因此,对病理组织学检查阴性的患者,也应严格随访。今后,免疫微环境和分子标记、源于患者的类器官培养、循环肿瘤细胞(CTC)和血浆游离DNA(cfDNA)等技术,可能有助于等待观察患者的筛查和监测。. | zh-cn |
pair_32192304 | For locally advanced (T3-4/N+M0) rectal cancer (LARC), radiation-based neoadjuvant therapy followed by total mesorectal excision (TME) is the standard treatment. For those who achieved clinical complete response (cCR), a non-operative management called 'watch and wait' (W&W) strategery can preserve organ function and i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 以放疗为基础的新辅助治疗联合全直肠系膜切除术(TME)是局部晚期直肠癌的标准治疗模式。对于获得临床完全缓解(cCR)的患者,采取非手术的'等待观察(W&W)'策略,能最大限度地保留器官功能、提高生活质量。对于W&W,放射治疗仍是其新辅助治疗不可或缺的核心环节,进一步提高肿瘤退缩程度及cCR率是其努力方向。本文着重对放射治疗在直肠癌新辅助治疗后W&W策略中的作用进行总结,同时从放疗、化疗、免疫治疗、间隔期等方面,对增加cCR率的优化策略进行阐述,如加强放疗同化疗、局部腔内加量、增加诱导和巩固化疗、联合免疫治疗以及延长放疗后间隔期等,期待能给患者带来更高的生存时间和生活质量。. | zh-cn |
pair_34098664 | The common chronic disorders in the world, such as cardiovascular diseases, diabetes mellitus, cancers, etc., are all the multi-factorial diseases. They are caused by the interactions of various risk factors among which inflammation plays an important role in the pathogenesis of all these chronic disorders. Any factor ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 心血管疾病、糖尿病、肿瘤等人类罹患的最普遍的慢性病,都是多因素疾病,这些疾病的发生发展是由多个危险因素共同作用的结果。炎症是这些系统性疾病的共同病理机制,任何造成或增强机体炎症状态的因素都可能成为这些系统性疾病的危险因素。牙周炎症过程中,无论是进入血液循环中的牙周致病菌和细菌组分(如细菌脂多糖)激发宿主的免疫炎症反应、产生一系列炎症因子,还是牙周病变组织局部产生的这些炎症因子进入血液循环,都可增强机体系统性的炎症状态,成为一系列以炎症为病理机制的系统性疾病的危险因素。. | zh-cn |
pair_34098665 | Gingival enlargement or hypertrophy is one of the common clinical symptoms in patients with periodontitis. Plaque stimulation, hormones and drug use could be the promoting factors for the occurrence of gingival enlargements. This paper reviews the literature on the pathogenesis, treatment methods and the effect of plaq... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 牙龈肥大是临床上常见的一种症状,菌斑刺激、激素、药物等均可导致牙龈肥大。本文通过回顾文献,对牙龈肥大的发病机制、治疗方法、控制菌斑和炎症对各种类型牙龈肥大的治疗效果等方面进行阐述,同时结合病例展示,进一步论述了控制菌斑和炎症对各种类型牙龈肥大的治疗效果,提出牙龈肥大的治疗方案建议,以期为临床工作提供参考。. | zh-cn |
pair_34098674 | To explore the technical process and the therapeutic effect of using sequential surgical guide with independent intellectual property rights assisting immediate implantation and restoration of the full arch, with the support from the periodontal splint for mobile supporting teeth, patients with severe periodontitis who... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 选取2019年8月至2020年12月于北京大学口腔医学院·口腔医院修复科、牙周科、种植科和门诊部就诊的、计划进行全牙弓即刻种植即刻修复的重度牙周炎患者,探讨牙周夹板结合序列手术导板辅助全牙弓即刻种植即刻修复治疗的技术流程和治疗效果。通过术前颌面部数据采集、系统性诊断设计、牙周夹板固定、导板制作、导板辅助下手术完成全牙弓即刻种植即刻修复8例,上颌7例,下颌1例;男性2例,女性6例,年龄(49.0±9.3)岁(38~65岁);共植入48枚种植体,其中直立植入44枚,倾斜植入4枚;前牙区16枚,后牙区32枚。配准术后锥形束CT和术前设计,测量种植体实际三维位置与术前设计位置的差异,以2 mm为临床可接受的安全范围。术中未见导板折裂或重要解... | zh-cn |
pair_34098676 | Periodontitis is closely related to systemic health, especially cardiovascular disease. Periodontal pathogens from periodontal infection actively participate in the formation and development of coronary atherosclerosis. At present, accumulcted evidences show that periodontal pathogen infection is an independent risk fa... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 牙周炎与全身健康特别是心血管疾病关系密切,牙周致病菌积极参与了动脉粥样硬化的形成与发展。目前已有研究证据表明,牙周致病菌感染是心血管事件的独立危险因素,其通过多种免疫炎症以及代谢相关分子机制促进动脉粥样硬化病变的发生发展。本文从牙周炎及牙周致病菌与心血管疾病的相关性、牙周致病菌影响动脉粥样硬化的机制等方面,对这一主题进行综述。. | zh-cn |
pair_34098677 | Periodontitis is a common chronic infectious oral disease, which is characterized by gingival inflammation,pocket formation, alveolar bone loss and tooth mobility. Psoriasis is a common chronic inflammatory skin disease, whose pathological features in skin lesions are excessive proliferation of epidermal cells, paraker... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 牙周炎是口腔常见的慢性感染性疾病,以牙龈炎症、牙周袋形成、牙槽骨吸收和牙齿松动为主要表现。银屑病是一种常见的慢性炎性皮肤病,皮损部位基本病理特点为表皮细胞过度增殖、皮肤角化不全及炎性细胞浸润。上述两种慢性炎性疾病的免疫病理机制均与炎性通路白介素(interleukin,IL)-23(IL-23)/辅助性T细胞17(helper T cell 17,Th17)/IL-17轴密切相关。银屑病的常见危险因素有吸烟、维生素D缺乏、肥胖和精神压力等,这些因素大多也是牙周炎的危险因素。鉴于此,本文将从临床研究、IL-23/Th17/IL-17通路、共同危险因素3个方面探究二者的联系以及相互影响的可能机制,以期为临床诊疗提供新思路。. | zh-cn |
pair_34098678 | Tissue clearing is a novel technique developed within recent years, which could make the tissue optical transparency using physical or chemical methods by refractive index matching. Combined with fluorescence imaging and three-dimensional reconstruction technology, it could achieve three-dimensional observing and analy... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 组织透明化技术是一项新兴技术,其原理是使用物理或化学的方法,通过匹配折射率使组织达到光学透明。组织透明化技术结合荧光成像及三维重建技术,可在细胞水平对组织的内容物和结构进行三维观察及分析。组织透明化技术多运用于软组织,对硬组织的研究相对较少。近年,很多学者改进了透明化技术,使之适用于骨和牙齿等硬组织。本文将对组织透明化技术在硬组织中的应用进展作一综述。. | zh-cn |
pair_34098679 | Dental pulp stem cell (DPSC), with a high capacity of multidirectional differentiation, is the key and preferred cell in the study of dental pulp and dentin regeneration. The effect of trace elements on the differentiation of DPSC is one of the research hotspots in the field of oral tissue engineering in recent years. ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_34098681 | Microorganism exerts a profound impact on the development and function of human immunity. Vice versa, immunity also affects the constitution and function of human microbiota. Hence, a new concept, immunomicroecology, has been put forward as an inevitable consequence of the development in the fields of microecology and ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 人体内的微生物可通过多种机制调控机体免疫系统的发育和功能,从而影响人类健康以及疾病的发生发展。反之,免疫系统也可影响人体微生态的构成和功能。随着微生态学和免疫学相关研究的深入,衍生出一个新的概念——免疫微生态学。本文对免疫微生态学的概念、发展历程、免疫系统和微生态之间的相互作用以及应用前景进行阐述。. | zh-cn |
pair_34098688 | Pathological myopia, an important blinding eye disease worldwide, has caused a heavy social burden. The patients have become younger in recent years. In general, people have limited knowledge of pathological myopia. They often confuse pathological myopia with high myopia, and do not fully realize that pathological myop... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 病理性近视眼已成为全球范围内重要的致盲性眼病,近年来有逐渐年轻化的趋势,造成了沉重的社会负担。人们对病理性近视眼认识普遍不足,常将病理性近视眼和高度近视眼相混淆,未充分认识到病理性近视眼不只是一类屈光不正性疾病,更是一类可致盲的眼底疾病。病理性近视眼眼底并发症是导致视力损伤的主要原因,主要包括后巩膜葡萄肿、黄斑退行性病变以及继发性脉络膜新生血管等,均与眼轴长度密切相关,可终身进展,且治疗手段有限。当下近视眼防控已上升至国家战略高度,病理性近视眼是近视眼防控中的重点和难点,全社会都应重视病理性近视眼眼底并发症的预防和治疗,采取针对性的综合防治措施,加大科研投入和成果转化,共同呵护国民眼健康<i>。(中华眼科杂志,2021,57:401... | zh-cn |
pair_34098689 | Day surgery is currently a rapidly developing medical service mode. Ophthalmology is more suitable for day surgery due to its disease characteristics. To promote the healthy development of ophthalmic day surgery in China, and to improve its standardized management to ensure the medical quality and patients' safety, the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 日间手术是目前发展迅速的手术医疗服务模式,眼科因其疾病诊疗特点更适合开展日间手术。为促进我国眼科日间手术推广和健康发展,提升眼科日间手术的规范化管理水平,保障医疗质量和患者安全,中国医药教育协会眼科委员会、中国老年医学学会眼科分会会同解放军医学科学技术委员会眼科学分会,在《我国眼科日间手术流程专家共识(2018年)》的基础上,针对眼科日间手术的设施建设、组织管理模式、手术执行的具体实施、质量与安全管理等环节,通过认真、全面、充分讨论达成共识性意见,为我国眼科临床开展日间手术提供更多指导。<i>(中华眼科杂志,2021,57:406-414)</i>. | zh-cn |
pair_34098695 | The proband was a 5-year-old boy with binocular esotropia since childhood. Ocular examination showed the binocular optic cup was wide and deep excavated with radial emergence of the retinal vessels and retinal detachment was seen in the left eye. The father of the proband with worse vision of the right eye from a child... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 先证者为5岁男童,自幼双眼内斜视,眼部检查示:双眼视杯宽而深,有多发睫状视网膜血管自盘周呈放射状发出,左眼可见视网膜神经上皮脱离。对先证者父母及妹妹行眼科检查,其父自述自幼右眼视力极差,10年前有肾移植病史。眼部检查示先证者父亲右眼视盘增大,血管走行异常,左眼视盘大小正常,多发视网膜血管自盘周放射状发出,可见黄斑区及视盘周围视网膜劈裂,右眼黄斑区视网膜神经上皮浅脱离。先证者妹妹双眼视杯宽而深,血管走行大致正常,黄斑区无明显异常。肾脏彩超及尿常规检查示先证者及其妹妹均可见双侧肾脏钙化灶及肾盂分离,轻度蛋白尿。基因检测结果示:先证者及其父亲、妹妹均存在PAX2基因c.419_421delGGA杂合突变。结合上述检查结果,诊断为:肾-视神... | zh-cn |
pair_34098696 | Choroidal thinning is an important feature of high myopia and has a negative correlation with the degree of myopia. However, due to the limitations of choroidal imaging, specific changes in choroidal thickness and vasculature are unclear. In recent years, the development of optical coherence tomography technology and o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 脉络膜变薄是高度近视眼的重要特征之一,且与近视程度相关。但因脉络膜显像技术具有局限性,有关脉络膜厚度及微血管系统改变的具体特征尚不清楚。近年来相干光层析成像术(OCT)和相干光层析血管成像术(OCTA)发展以及脉络膜厚度和微血管变化客观量化指标出现,有助于临床进一步探讨高度近视眼的发病机制,进而为治疗近视眼并评估预后提供新途径。本文综述近年来OCT和OCTA在高度近视眼脉络膜形态学改变研究中的应用及进展,并讨论其与人工智能相结合进行脉络膜显像时存在的问题与发展前景,以期为临床开展相关工作提供参考。<i>(中华眼科杂志,2021,57:459-464)</i>. | zh-cn |
pair_34098697 | The application of artificial intelligence (AI) in ophthalmology will greatly reduce the workload of ophthalmologists. Machine learning is an important branch of AI, and deep learning is the most important algorithm in machine learning. At present, AI is well applied in the ophthalmic field. This article summarizes the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 人工智能在眼科的应用将极大减轻眼科临床医师的工作量。机器学习是人工智能的重要分支,深度学习是机器学习中最重要的算法。目前人工智能在眼科已有了成熟的应用。本文汇总近年文献,总结人工智能在眼科的应用,探讨眼科人工智能的不足并展望其未来,以期为在眼科临床进一步发挥人工智能作用提供参考。<i>(中华眼科杂志,2021,57:465-469)</i>. | zh-cn |
pair_34098698 | Myopia has become an important global public health problem, especially in East Asia. Due to its high prevalence and multiple ocular complications, it is imperative to take effective measures against the development of myopia. Recent studies have shown that outdoor activity is one of the protective factors for myopia a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近视眼已成为一个重要的全球性健康问题,在东亚地区尤为严重。鉴于其患病率高,眼部并发症多,目前急需采取有效措施遏止近视眼患病人数的迅猛发展。近期研究结果表明,户外活动是近视眼的保护因素,且日光可以延缓近视眼的进展,因而作为日光与近视眼之间潜在媒介的维生素D便逐渐进入人们的视野中。维生素D是一种脂溶性维生素,主要负责调节钙磷代谢,此外它还与多种眼病相关,例如糖尿病视网膜病变、年龄相关性黄斑变性、青光眼等。本文总结了与维生素D和近视眼相关的流行病学研究和遗传学研究成果,并探讨了可能的生物学机制,为利用维生素D进行近视眼防治提供理论参考<i>。(中华眼科杂志,2021,57:470-476)</i>. | zh-cn |
pair_34098699 | Lee T'ao(1901-1959),studied at Beijing National Medical Institute in 1921.He worked at the Chinese Department of Concord Medical Institute from 1928-1942. He studied medical history and taught the history of western and Chinese medicines. He finished <i>Medical History Profile</i> in 1940.During this period, he and Con... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 李涛(1901—1959)于1921年就读于国立北京医学专门学校。1928—1942年供职于协和医学院中文部,讲授中外医学历史,从事医史研究,并于1940年完成《医学史纲》。此期间李涛曾积极为协和医学院图书馆搜罗中医古籍,并成为中华医史学会主要领头人之一。1946年后供职北京大学医学院(后更名北京医学院),担任医史教研室主任、教授,参与编辑《医史杂志》,编制最早的中医图书联合目录,发表了一批视野开阔、角度新颖的中国医学史研究论文。在医史教学与科研方面,李涛特别注重实物及实地考察所得的医学史料,深入调查历代医史遗迹。1954年,李涛兼任中央卫生研究院医史研究室主任,1956年与陈邦贤联袂举办医史高级师资进修班,为医史学科培养了一批接班... | zh-cn |
pair_34098701 | The creation of oral contraceptives goes back 60 years. It has gone through a long and complex process from the discovery of sex hormones to their development into drugs to market. A correct understanding of the developmental history of oral contraceptives is of great importance for human reproduction. Gregory G Pincus... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 从性激素的发现到将其研制成口服避孕药直至上市,经历了漫长而又曲折的过程。口服避孕药诞生已有61周年,第一种口服避孕药“异炔诺酮(以Enovid为商标)”于1960年5月由美国联邦药物管理局(FDA)批准上市。目前口服避孕药仍是一种非常流行的节育形式。口服避孕药的研发是人类历史上的一项重大成就。在这期间,一大批优秀的内分泌学家和化学家为口服避孕药的诞生和发展作出卓越的贡献。口服避孕药的诞生不仅缓解了第二次世界大战后世界人口爆炸式增长的局面并且提高了女性的社会地位,但同时也催化出了性解放运动。. | zh-cn |
pair_34098702 | Intelligent medicine is a discipline system developed and established in the background of a rapid development of science and technology. Information technology represented by artificial intelligence, VR(virtual reality) technology and the 1G (first-generation) communication laid a foundation for intelligent medicine. ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 智能医学是在科技迅猛发展的时代背景下快速发展并壮大成形的学科体系。早期人工智能,VR技术,移动通信等信息化技术为其发展奠定了基础;手术机器人,3D打印,可穿戴设备等促进智能医学进一步发展;如今智能医学已应用于医学影像、辅助诊断、手术操作、医院管理、药物研发、健康体系等医疗体系的各个方面。以5G医疗、医学云平台/大数据、先进材料合成、4D打印、AR/MR、超级智能等为代表的一系列前沿科技将推动人类全面进入智能医学时代。. | zh-cn |
pair_34098703 | The quarantine and treatment plays an important role in prevention and control of respiratory infectious diseases. It has been nearly 200 years since sanatorium model was adopted to isolate and treat patients with tuberculosis(TB). The era of the Republic of China was an important period for the model to sprout and exp... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 隔离治疗对于呼吸道传染病的防控有重要作用,采取疗养院模式隔离治疗结核病患者距今已有近200年历史,民国时期是中国该模式从萌芽到发展的重要时期。中国结核病疗养院在20世纪初开始建立,30年代达到顶峰。研究民国时期北平、上海、杭州等地结核病疗养院创立与变迁的情况,对于梳理中国结核事业发展的历史线索,探索结核病防控的历史规律,总结历史经验具有重要意义。. | zh-cn |
pair_34098705 | The Macau Baimahang Hospital (Hospital de S. Rafael), took more than 400 years from 1569 to 1975 to develop as a comprehensive western medicine hospital , and is believed to be one of the earliest western medicine hospitals in China. Up to now, very little has been written about it as most of the records are kept in Ma... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 澳门白马行医院从1569年开办至1975年关闭,历时400余年,是迄今为止中国历时最长、历史最悠久的西医院。由于留存文献在澳门,中文资料少,很少被关注介绍。笔者综合利用各档案文献,并实地考察,为诸同道进一步研究提供参考与借鉴。. | zh-cn |
pair_34098706 | The concept of 'Xing & Shen'(Body and spirit) and their relationship are important philosophical categories and basic issues in life cognition. The view of 'body and spirit' in Chinese medicine is the inheritance and development of the concept of 'form and spirit' in ancient Chinese philosophy; the view of body-spirit ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | “形神”概念及其关系,是重要的哲学范畴,也是生命认知中的基本问题。中医学的形神观,是对中国古代哲学“形神”思辨的继承与发展;“形神一体”的形神观反映了中医学的整体观念,是中医原创思维模式的要素之一。以金元四大家对于中医“形神观”的阐发为切入点,结合当时社会背景,发现他们的学术创新与其儒医身份及经典研习之间存在重要关联。. | zh-cn |
pair_34102722 | Pancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf of the Group of Pancreatic Surgery, Chinese Society of Surgery, Chinese Medical Association, which consisted of surgical... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胰腺神经内分泌肿瘤具有高度的异质性,患者的临床管理存在一定难度。为了应对这一挑战,中华医学会外科学分会胰腺外科学组牵头成立了由肿瘤外科、消化内科、肿瘤内科、内分泌科、影像科、病理科、核医学科等多领域学者组成的专家委员会。该委员会回顾了与胰腺神经内分泌肿瘤诊断和治疗相关的重要问题,并基于循证医学证据提出了相应的诊疗建议,以期进一步改进中国胰腺神经内分泌肿瘤患者的诊疗流程。. | zh-cn |
pair_34102723 | To further improve the standard of diagnosis and treatment of acute biliary tract infections in China, the Branch of Biliary Surgery, Society of Surgery, Chinese Medical Association has revised the guidelines for the diagnosis and treatment of acute biliary tract infections (2011).The guidelines describe the risk facto... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 为规范和提高我国急性胆道系统感染诊断和治疗水平,中华医学会外科学分会胆道外科学组依据最新文献和循证医学证据更新修订了《急性胆道系统感染的诊断和治疗指南(2011版)》。本指南阐述了急性胆道系统感染发病的危险因素及诊断和严重程度分级标准,并明确了急性胆道系统感染的治疗方法,希望能进一步规范抗菌药物的使用。急性胆道系统感染的治疗应综合外科干预、抗菌药物治疗和全身管理,在专科医师主导下,采取合理诊疗措施,准确把握手术方式和时机,规范使用抗菌药物,使患者获得最佳治疗获益。. | zh-cn |
pair_34102724 | Prosthetic joint infection is one of the most serious complications after artificial joint replacement.Accurate diagnosis and proper standardized treatment are the keys to improve the cure rate of prosthetic joint infection,reduce the rate of recurrence and disability,and restore limb function.Regarding the diagnosis a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 人工关节感染(PJI)是人工关节置换术后的严重并发症,准确的诊断与合理规范的治疗是提高PJI治愈率、降低复发率与致残率、恢复肢体功能的关键。尽管近年来关于PJI的诊断与治疗方面的研究进展迅速,但仍有许多问题尚未得到很好的理解与阐释,许多方面存在较大的意见分歧与争议,临床医师的诊疗工作存在诸多困惑。为了使国内PJI的诊疗工作更加规范,中华医学会骨科学分会关节外科学组组织国内相关领域专家,检索文献资料,整合专家意见,制定本指南,就PJI的诊断标准、规范化诊断流程、重要辅助检查的合理应用、治疗原则及各类治疗方案的选择等重点、难点问题进行阐述,并提出具有针对性和可操作性的建议,希望为国内同道在PJI的诊治方面提供参考。. | zh-cn |
pair_34102725 | In recent years, the endovascular procedures has considerably evolved in concepts, technologies, materials and devices on cardiovascular surgery, and influenced the development and the future direction of cardiovascular surgery technology. Endovascular aorta repair is well recognized as the optimal therapy for patients... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年来,心血管外科领域经导管腔内治疗的理念、技术、材料发展迅速,适应证不断扩展,深刻影响着心血管外科技术的发展方向。主动脉腔内修复术已成为急、慢性远端主动脉弓或胸部降主动脉、腹主动脉病变的常规治疗方法,在升主动脉疾病包括升主动脉瘤、假性动脉瘤及急慢性夹层、壁间血肿、穿透性溃疡等的治疗中亦受到关注并有相应报道。相比于经典外科开放手术,腔内修复术具有微创优势,增加了高危患者的治疗选择。由于升主动脉和主动脉根部解剖结构特殊,支架材料和手术器械选择有限,腔内修复术还存在很多亟待解决的问题。该术式的中长期疗效亦缺乏可靠的临床证据,其安全性和有效性尚需进一步研究。. | zh-cn |
pair_34102726 | Hepatocellular carcinoma(HCC) is a common malignant tumor with high morbidity and mortality in China and even in the world.Due to its tumor heterogeneity and dissemination and distant metastasis,prognosis of patients with HCC is often poor.Surgical treatment such as radical hepatectomy is still the first choice for pat... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝细胞癌是我国乃至世界上发病率和死亡率较高的常见恶性肿瘤。由于其具有肿瘤异质性且易发生远处播散转移,患者的预后往往较差。目前,以根治性肝切除术为主的外科治疗仍是肝癌患者治疗的首选方案,但术后的高复发转移率仍然阻碍着患者生存预后的改善。因此,在靶向免疫治疗时代,肝癌外科治疗策略的转变就显得尤为关键。本文聚焦新辅助治疗的定义、在肝癌中的可行性、评估标准等方面,旨在为今后肝癌外科治疗提供新的视角。. | zh-cn |
pair_34102727 | With the popularization of minimally invasive concept in the treatment of lumbar degenerative disease,minimally invasive lumbar interbody fusion has gradually developed into the mainstream technique of lumbar fixation and fusion.At present,there are many types of minimally invasive lumbar interbody fusion. In this pape... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着微创理念在腰椎疾病诊疗中的普及,微创腰椎椎间融合术逐渐发展为腰椎固定融合术的主流术式。微创腰椎椎间融合术种类繁多,本文从适应证选择、技术特点、临床疗效和并发症防治等方面,系统阐述了当前临床上应用较为广泛的微创前路腰椎椎间融合术、微创经椎间孔入路腰椎椎间融合术、极外侧入路腰椎椎间融合术和斜外侧入路腰椎椎间融合术等4种微创腰椎椎间融合术。为了以最小创伤获得最佳的治疗效果,需要术者在严格把握适应证的基础上,详细制订手术策略,并根据自己的临床经验和技能来选择融合方式,使不同术式发挥出最大优势。. | zh-cn |
pair_34102741 | Unicompartmental knee arthroplasty(UKA) is an important surgical technique for the treatment of end-stage knee osteoarthritis, which has high requirement for the position and angle of the prosthesis. The application of three-dimensional(3D) printed in UKA reflects several characteristics such as accuracy,efficiency and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 单髁置换术(UKA)是治疗终末期膝关节骨关节炎的一种重要的外科手段,其对假体位置和角度的精准度要求较高。三维打印导板应用于UKA可以提高手术精准性,术中操作便捷,安全性高。但目前导板的设计、假体位置参数等尚缺乏统一标准。本文梳理了UKA术中三维打印导板的历史、制作要求和过程,以及目前的临床研究结果。三维打印导板是否可以安全、有效地提高无经验医师在UKA术中的假体安放精准度,以及长期结果是否值得在临床上进行推广仍有待进一步的验证。. | zh-cn |
pair_34102742 | Curcumin is the main active component of Curcuma longa,which has a variety of biological activities and pharmacological properties.Clinical studies have shown that curcumin and its derivatives can improve the pathological progress of osteoarthritis. The mechanism mainly includes enhancing the activity of antioxidant en... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 姜黄素是姜黄的主要活性成分。姜黄素及其衍生物可以减缓骨关节炎的病理进展,其作用机制包括增强抗氧化酶活性,抑制氧化应激和软骨细胞凋亡,发挥软骨保护作用;通过阻断炎症相关的信号转导通路,减少炎性因子生成并降低活性,减轻炎症反应;通过与免疫细胞和免疫分子的相互作用调节免疫功能等。姜黄素可减轻骨关节炎患者疼痛症状、改善关节功能和患者生活质量,已成为潜在的抗骨关节炎药物之一。. | zh-cn |
pair_34102743 | The anti-tumor mechanism of tumor treating fields (TTFields) is mainly through interfering with the dynamics of microtubule subunits in mitosis,which blocks the normal process of cell division and eventually leads to cell death.In recent years,relevant studies have found that TTFields still have immunological,molecular... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肿瘤电场治疗(TTFields)的抗肿瘤机制主要是通过干扰有丝分裂中微管亚基的动力学行为,使细胞正常分裂过程受阻,最终导致细胞死亡。近年来,相关研究发现TTFields尚存在免疫学、分子生物学等相关抗肿瘤机制,并可诱导细胞膜和血脑屏障通透性可逆性升高,在与抗肿瘤药物联合使用时发挥协同作用。随着多系统研究的不断开展,TTFields在不同瘤种治疗中的特异性治疗频率、时间和场强等将不断被揭示,进一步扩展TTFields的应用领域,惠及更多患者。. | zh-cn |
pair_34105194 | Serological allergen testing (SAT) is used widely to formulate allergen-specific immunotherapy for atopic dogs. Serum immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) can produce false-positive reactions, creating discrepancy between SAT and intradermal allergen test (IDAT) results. The ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 血清学过敏原检测(SAT)广泛用于制定特应性犬的过敏原特异性免疫治疗。交叉反应性碳水化合物决定簇(CCD)特异性血清免疫球蛋白(Ig)E可产生假阳性反应, 导致SAT和皮内过敏原试验(IDAT)结果之间的差异。 目的: 主要目的是确定在商业检测中抑制抗CCD IgE是否改善与IDAT的相关性。次要目的是评估犬和临床特异性因素、环境因素、假定过敏原暴露和既往用药对皮内和SAT反应性的影响。 动物: 211只客户拥有的犬来自北美的8个皮肤专科诊所。 方法和材料: 在同一天进行血清样本采集和IDAT。在用抗CCD IgE的专用抑制剂处理前后, 测定血清中25种过敏原特异性IgE的检测。通过兽医人员填写的调查问卷收集每只犬的数据。 ... | zh-cn |
pair_34105194 | Serological allergen testing (SAT) is used widely to formulate allergen-specific immunotherapy for atopic dogs. Serum immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) can produce false-positive reactions, creating discrepancy between SAT and intradermal allergen test (IDAT) results. The ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Les tests allergologiques sériques (SAT) sont largement utilisés pour composer l’immunothérapie spécifique d’allergènes des chiens atopiques. Les immunoglobulines (Ig) E sériques spécifiques des CCD (cross-reactive carbohydrate determinants) peuvent engendrer des faux positifs, créant un décalage entre les résultats de... | fr |
pair_34105194 | Serological allergen testing (SAT) is used widely to formulate allergen-specific immunotherapy for atopic dogs. Serum immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) can produce false-positive reactions, creating discrepancy between SAT and intradermal allergen test (IDAT) results. The ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Serologische Allergentests (SAT) werden weithin eingesetzt, um eine Allergen-spezifische Immuntherapie für atopische Hunde zu formulieren. Serum Immunglobulin (Ig)E spezifisch für kreuzreaktive Kohlenhydratdeterminanten (CCD) können falsch-positive Reaktionen verursachen, was eine Diskrepanz zwischen SAT und Intraderma... | de |
pair_34105194 | Serological allergen testing (SAT) is used widely to formulate allergen-specific immunotherapy for atopic dogs. Serum immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) can produce false-positive reactions, creating discrepancy between SAT and intradermal allergen test (IDAT) results. The ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | O teste sorológico de alérgenos (TAS) é amplamente utilizado para formular imunoterapia alérgeno-específica para cães atópicos. A imunoglobulina (Ig)E sérica específica para determinantes de carboidratos de reação cruzada (CCD) pode produzir reações falso-positivas, criando discrepância entre os resultados do TAS e do ... | pt |
pair_34105194 | Serological allergen testing (SAT) is used widely to formulate allergen-specific immunotherapy for atopic dogs. Serum immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) can produce false-positive reactions, creating discrepancy between SAT and intradermal allergen test (IDAT) results. The ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la prueba serológica de alérgenos (SAT) se usa ampliamente para formular inmunoterapia específica de alérgenos para perros atópicos. La inmunoglobulina (Ig)E sérica específica para determinantes de carbohidratos de reacción cruzada (CCD) puede producir reacciones positivas falsas, creando discrepancias entre los result... | es |
pair_34105453 | To investigate the expression of WTAP gene in acute myeloid leukemia (AML) and its clinical significance. 74 acute myeloid leukemia patients with non-M3 type and 19 normal donors were selected, and real-time quantitative polymerase chain reaction was used to detect the mRNA expression level of WTAP gene in their bone m... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | WTAP基因在初诊急性髓系白血病中的mRNA表达及其临床意义. 探讨WTAP基因在初诊急性髓系白血病(AML)中的表达及其临床意义. 选取本院初诊非M3类型的AML患者的骨髓样本74例,以正常供体骨髓样本19例作为对照组。应用实时定量聚合酶链反应技术检测骨髓细胞中WTAP基因mRNA的表达水平,并分析WTAP基因mRNA表达水平与患者疾病亚型、初诊时临床特征和预后之间的关系. 非M3型的AML组WTAP mRNA相对表达量明显高于健康对照,比较差异有统计学意义(P< 0.01)。按照法、美、英协作组(FAB)分型,各亚型间表达差异无统计学意义(均P>0.05)。在非M3型AML患者中,FLT3-ITD基因突变阳性组的WTAP mRN... | zh-cn |
pair_34105454 | To analyze the efficacy of CCLG-ALL-2008 protocol and the related factors of treatment failure in children with acute lymphoblastic leukemia (ALL). The clinical data of 400 children newly-diagnosed ALL in Children's Hospital of Soochow University from March 1, 2008 to December 31, 2012 was retrospectively analyzed. All... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 儿童急性淋巴细胞白血病治疗失败的相关因素分析. 分析儿童急性淋巴细胞白血病(ALL)接受CCLG-ALL-2008方案治疗的临床疗效和治疗失败的相关因. 回顾性分析2008年3月1日至2012年12月31日在苏州大学附属儿童医院新诊断为ALL并接受CCLG-ALL- 2008方案治疗的400例患儿的临床资料,并随访到2019年10月,记录患儿复发和死亡时间及死亡原因。治疗失败定义为复发、非复发性死亡和二次肿瘤. 随访10年,共有152例患儿出现复发或者非复发性死亡,治疗失败率为38%,其中复发122例(80.3%),非复发性死亡30例(19.7%)。非复发性死亡包括治疗相关性死亡7例(占23.3%,感染死亡4例,出血死亡3例),骨髓... | zh-cn |
pair_34105455 | To analyze the changes in the gene expression profile of T cells in CML patients after TCRζ up-regulation expression, and to explore the molecular mechanism of T cell reactivation after transgenic up-regulation of TCRζ. The peripheral blood mononuclear cells(PBMCs) from 3 newly untreated chronic-stage CML patients were... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_34105456 | To analysis the relationship between different BMI (body mass index) and the clinical characteristics, laboratory examination indexes of newly diagnosed adult patients with acute myeloid leukemia (AML), so as to investigate the effects of BMI to the efficacy of first induction chemotherapy. The clinical data of 145 new... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 体质量指数与成人急性髓系白血病关系的分析. 分析不同体质量指数(BMI)与成人初诊急性髓系白血病(AML)患者的临床特征、实验室检查指标的关系及对首次诱导化疗效果的影响. 回顾性分析兰州大学第一医院血液科2015年8月至2019年8月初诊的成人AML患者145例(急性早幼粒细胞白血病除外)的临床资料。根据中国成人超重和肥胖症预防控制指南,计算入选的AML患者诱导化疗前的BMI(kg/m<sup>2</sup>)值,分为低体质量组(BMI<18.5)、正常体质量组(18.5≤BMI≤23.9)、超重及肥胖组(BMI≥24)。收集患者性别、年龄、危险分层、白血病类型、基因突变、合并症、住院时间等临床特征,白细胞(WBC)、血红蛋白(Hb... | zh-cn |
pair_34105457 | To investigate the effect of V-9302 (an antagonist of transmembrane glutamine flux) on the proliferation and apoptosis of acute myeloid leukemia cells HL-60 and KG-1. HL-60 and KG-1 cells at logarithmic phase were treated by different concentrations of V-9302. CCK-8 assay was used to detect the proliferation of the cel... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 跨膜谷氨酰胺通量的竞争性拮抗剂V-9302对急性髓系白血病细胞系HL-60、KG-1凋亡的影响. 研究跨膜谷氨酰胺通量的拮抗剂V-9302对急性髓系白血病细胞增殖、凋亡的影响. 取对数生长期的HL-60、KG-1细胞,给予不同浓度V-9302处理,CCK-8检测细胞增殖情况,采用Annexin V-FITC/PI双染色流式细胞术检测细胞的凋亡率,采用RT-qPCR、Western blot检测凋亡相关基因BAX、BCL-2、Caspase3的表达. V-9302可以显著抑制HL-60、KG-1细胞的生长(P<0.05),10和20 μmol/L的V-9302分别作用于HL-60、KG-1细胞系后,能显著促进细胞的凋亡(P<0.05)... | zh-cn |
pair_34105458 | To investigate the relationship between single nucleotide polymorphisms (SNPs) of IKAROS family Zinc finger 3 (IKZF3) gene and the risk of acute lymphoblastic leukemia (ALL) in children. The peripheral blood samples from 286 children with ALL and 382 healthy children were collected and divided into ALL group and contro... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | IKZF3基因单核苷酸多态性与儿童急性淋巴细胞白血病的关系. 探讨IKAROS家族锌指蛋白3(IKZF3)基因单核苷酸多态性与儿童急性淋巴细胞白血病(ALL)发病风险的关系. 收集286例ALL患儿以及382例健康儿童的外周血样本,分别作为ALL组和对照组。采用TaqMan探针实时定量PCR技术检测IKZF3基因rs62066988 C > T和rs12946510 C > T 两个单核苷酸多态性位点的基因型分布情况,并分析二者与ALL的相关性. rs62066988位点的CC、CT和TT基因型在ALL组的分布频率分别为58.39%、37.06%和4.55%,在对照组的分布频率分别为69.19%、27.68%和3.13%。rs129... | zh-cn |
pair_34105459 | To observe the clinical efficacy of allogeneic peripheral blood stem cell transplantation(allo-HSCT) on the treatment of adult acute leukemia patients, moreover, to establish and evaluate a Logistic model to predict the risk of relapse in adult acute leukemia patients after allo-HSCT. The clinical data of 145 adult acu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 异基因外周血造血干细胞移植治疗成人急性白血病疗效及移植后复发风险预测模型的建立. 观察成人急性白血病异基因外周血造血干细胞移植的临床疗效,并建立预测急性白血病移植后复发风险的Logistics模型. 选取西安交通大学第一附属医院2010年1月至2019年12月收治的行异基因外周血造血干细胞移植的成人急性白血病患者145例及其供者的临床资料,观察移植后并发症及生存情况;通过多因素Logistics回归分析患者年龄、诊断、起病时白细胞数、危险度分层、移植前微小残留病灶、诊断到移植的时间、HCT-CI、供受者性别关系、HLA配型相合程度、移植物抗宿主病(GVHD)预防方案、供者年龄、输注单个核细胞及CD34+细胞数、造血重建时间、有无急慢... | zh-cn |
pair_34105460 | To investigate the regulatory effects of RBM47 on HMGA2 and the function of RBM47 in human chronic myeloid leukemia cell K562. K562 cells were transduction by the overexpressed and knockdown RBM47 lentiviral vector. CCK-8 assay was used to detect the effect of RBM47 on the proliferation of K562 cells. Flow cytometry as... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | RNA结合蛋白RBM47通过调节HMGA2抑制K562细胞的增殖. 研究RBM47对下游基因HMGA2的调控作用,以及对人慢性髓系白血病细胞株K562增殖的调控作用. 使用过表达、敲低RBM47的慢病毒载体感染K562细胞,CCK-8法检测RBM47对K562细胞增殖的影响,流式细胞术检测RBM47对K562细胞周期的影响;通过RNA免疫共沉淀结合方法检测RBM47与HMGA2 mRNA的结合情况,逆转录实时定量PCR方法检测RBM47对HMGA2 mRNA稳定性的影响,Western blot检测RBM47对HMGA2蛋白表达的影响. 在K562细胞内过表达RBM47可抑制K562细胞的增殖和周期运行,抑制RBM47则可显著促进K... | zh-cn |
pair_34105461 | To investigate the relationship between average interval time of chemotherapy and prognosis in patients with acute leukemia (AL) during intensive treatment. Data of 92 newly treated adult AL patients who received chemotherapy in The First Hospital of Lanzhou University from January 2010 to June 2019 were analyzed retro... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 急性白血病患者化疗间隔时间与预后的相关性分析. 探讨急性白血病患者强化治疗期间平均化疗间隔时间与预后的关系. 回顾性分析2010年1月至2019年6月在兰州大学第一医院接受化学治疗的92例初治成人急性白血病患者的资料,依据强化治疗期间平均化疗间隔时间进行分组并分析其对预后的影响. 强化治疗期间平均化疗间隔时间中位水平为38(20-64)d,依据化疗平均间隔时间水平将患者分为<30 d、30-39 d、40-49 d、≥50 d组,4组患者3年总生存率分别为(84.9±8.0)%、(73.5± 8.7)%、(56.5±11.1)%和(41.8±13.6)%(P=0.008),3年无进展生存率分别为(63.6±11.1)%、(52.8±... | zh-cn |
pair_34105463 | To retrospective analyze the reason of death in children with acute lymphoblastic leukemia (ALL) treated with CCLG-ALL 2008 protocol, and the experience was summarized in order to reduce the mortality. 916 children diagnosed as ALL and accepted CCLG-ALL 2008 protocol from April 2008 to April 2015 in our hospital were e... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | CCLG-ALL2008方案治疗儿童急性淋巴细胞白血病死亡病例分析. 回顾性分析应用CCLG-ALL2008方案治疗儿童急性淋巴细胞白血病(ALL)患者的死亡原因,总结经验,以期降低患儿死亡率. 2008年4月至2015年4月在本院诊断并接受CCLG-ALL2008方案治疗的儿童ALL患者共计916例,选取其中死亡的病例进行回顾性分析. 死亡患者共169例,男性111例(65.7%),女性58例(34.3%)。复发为主要的死亡原因,由复发导致死亡的患者有150例(88.7%),其中86例(57.3%)复发后家属直接放弃治疗。第二死亡原因为感染,感染部位主要集中在呼吸系统和消化系统,以细菌感染为主(多见于革兰氏阴性杆菌). 加强经济支... | zh-cn |
pair_34105464 | To investigate the predictive value of methyltransferase EZH2 expression level on the clinical efficacy and long-term prognosis of patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL). 161 patients with newly treated PGI-DLBCL in our hospital from August 2013 to July 2019 were selected. The ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 甲基转移酶EZH2表达水平对原发性胃肠道弥漫大B细胞淋巴瘤患者临床疗效及远期预后的预测价值分析. 探讨甲基转移酶EZH2表达水平对原发性胃肠道弥漫大B细胞淋巴瘤(PGI-DLBCL)患者的临床疗效及远期预后的预测价值. 选择2013年8月-2019年7月本院161例初治的PGI-DLBCL患者,检测其EZH2蛋白表达水平,比较不同水平EZH2患者的近期疗效及远期生存差异;Log-rank检验及COX风险比例回归模型统计分析EZH2表达水平对PGI-DLBCL预后的预测价值;卡方检验及Logistic回归法分析EZH2表达水平的影响因素. EZH2高表达患者完全缓解率、总缓解率均明显低于低表达患者(P<0.001)。EZH2高、低水平... | zh-cn |
pair_34105465 | To explore the value of interim <sup>18</sup>F-FDG PET/CT in the prognosis of patients with extranodal NK/T-cell lymphoma, nasal type (ENKTL). Twenty-one patients with ENKTL who were pathologically diagnosed at Shanghai General Hospital of Nanjing Medical University (Shanghai General Hospital) from January 2015 to Dece... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 中期 <sup>18</sup>F-FDG PET/CT评估结外鼻型NK/T细胞淋巴瘤的预后价值. 探讨中期<sup>18</sup>F-FDG PET/CT在结外鼻型NK/T细胞淋巴瘤(ENKTL)患者预后评估中的价值. 回顾性收集2015年1月至2018年12月在南京医科大学附属上海一院临床医学院(上海市第一人民医院)病理确诊的ENKTL患者21例,在治疗前和中期(2-4个化疗疗程后第3周或放疗后第6周)行<sup>18</sup>F-FDG PET/CT显像。随访患者完整临床资料,通过韩国预后指数计算、多维尔评分、最大标准摄取值减少率(ΔSUVmax)半定量分析评估患者的无进展生存率及总生存率,并通过COX回归分析影响生存的独... | zh-cn |
pair_34105466 | To investigate the clinical characteristics of patients with extranodal NK/T-cell lymphoma (ENKL), and to analyze the factors that affecting the survival and prognostic of patients treated with pegaspargase based chemotherapy. The clinical data of 61 ENKL patients treated in Peking Union Medical College Hospital from J... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 单中心结外NK/T细胞淋巴瘤患者临床特点及基于培门冬酶化疗的预后分析. 探讨结外NK/T细胞淋巴瘤患者的临床特点,以及应用以培门冬酶为基础的化疗方案的患者的疗效、生存情况及预后影响因素. 回顾性分析2015年1月至2019年6月于北京协和医院病理确诊和治疗的61例结外NK/T细胞淋巴瘤患者的临床资料,探究其临床特点、生存情况及预后的影响因素. 整组患者男女比例为2.8∶1,中位发病年龄为46(17-67)岁。Ann Arbor分期I/II期患者30例,III/IV期患者31例,鼻型与非鼻型的比例为4.1∶1。结外受累常见部位为皮肤及皮下组织(26.2%)、肝脏(14.8%)、肺(13.1%)及胃肠道(13.1%)。中枢受累比例为9.... | zh-cn |
pair_34105467 | To analyze gene expression profile of T cell lymphoma Jurkat cell line treated with paclitaxel by computational biology based on next generation sequencing and to explore the possible molecular mechanism of paclitaxel resistance to T cell lymphoma at gene level. IC50 of paclitaxel on Jurkat cell line was determined by ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 基于高通量测序及公共数据库探索紫杉醇抑制T细胞淋巴瘤机制. 通过二代测序技术对紫杉醇作用下T细胞淋巴瘤细胞株Jurkat基因表达谱进行计算生物学分析,以在基因层面探讨紫杉醇抗T细胞淋巴瘤的可能分子机制. 采用CCK-8法确定紫杉醇作用于Jurkat细胞的IC50,应用二代测序技术获得紫杉醇作用Jurkat细胞后基因表达谱,同时从GEO数据库中筛出与人T细胞淋巴瘤相关的基因芯片数据(其中包括720例T细胞淋巴瘤和153例正常对照组织),结合测序数据结果二者取交集并筛选差异表达基因(DEG);使用DAVID数据库进行GO功能和KEGG通路富集分析,确定和可视化DEG的功能条目,并绘制DEG的蛋白质相互作用网络图。使用RT-qPCR验证基... | zh-cn |
pair_34105468 | To investigate the clinical characteristics and risk factors of nosocomial infection in patients with non-Hodgkin lymphoma (NHL), in order to guide better clinical prevention and treatment of nosocomial infection. The incidence of nosocomial infection, infection site, characteristics of pathogenic bacteria, drug sensit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 472例非霍奇金淋巴瘤患者医院感染的临床特征及危险因素分析. 探讨非霍奇金淋巴瘤(NHL)患者医院感染的临床特征及危险因素,指导临床更好地防治医院感染. 回顾性分析2015年1月至2020年9月由福建医科大学附属第二医院收治的472例NHL患者医院感染的发生率、感染部位、病原菌特点、药敏实验结果及感染危险因素. 472例患者中有97例(20.6%)发生医院感染,感染部位以下呼吸道为主,占41.2%,其次为口腔、上呼吸道、泌尿生殖道及血液。共分离出病原菌71株,革兰阴性(G<sup>-</sup>)菌占52.1%,革兰阳性(G<sup>+</sup>)菌占28.2%,真菌占19.7%。超广谱β-内酰胺酶在肺炎克雷伯菌及大肠埃希菌中的检... | zh-cn |
pair_34105469 | To investigate the relationship between the polymorphism of miR-155 and its target gene MyD88 and clinicopathological features of diffuse large B-cell lymphoma (DLBCL). 135 cases of DLBCL patients in our hospital from March 2015 to August 2017 were selected, and 90 cases of reactive hyperplasia of lymph nodes were sele... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | miR-155及其靶基因MyD88基因多态性与弥漫大B细胞淋巴瘤临床病理特征的关系. 探讨分析miR-155及其靶基因MyD88基因多态性与弥漫大B细胞淋巴瘤(DLBCL)临床病理特征的关系. 选择2015年3月-2017年8月本院收治的DLBCL患者135例,另外选择淋巴结反应性增生标本90例作为对照组。检测2组受试者miR-155相对表达量及MyD88基因多态性,并分析miR-155及MyD88基因多态性与DLBCL临床病理特征的关系. DLBCL患者miR-155相对表达量显著高于对照组(P<0.05)。DLBCL组患者MyD88 L265P位点突变率显著高于对照组(P<0.05)。MyD88 L265P位点突变型DLBCL患... | zh-cn |
pair_34105470 | To analyze the influence of bone marrow involvement (BMI) in patients with malignant lymphoma (ML) on laboratory indexes, and evaluate the laboratory markers that can be used to predict/diagnose BMI. The clinical characteristics and laboratory indexes of 137 ML patients were analyzed retrospectively, from which the ind... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 实验室指标对恶性淋巴瘤患者骨髓浸润的预测价值分析. 分析恶性淋巴瘤(ML)患者骨髓浸润(BMI)对实验室检测指标的影响,并评估可用于预测/诊断BMI的实验室标志物. 回顾性分析137例ML患者的临床特征和实验室指标检测结果,研究ML患者合并BMI对实验室指标的影响,使用逻辑回归分析和受试者工作曲线(ROC)评估ML患者BMI的独立危险因素和预测变量的诊断价值. 与非BMI组相比,BMI组的红细胞分布宽度、C反应蛋白、血沉、D-二聚体、乳酸脱氢酶、碱性磷酸酶、β<sub>2</sub>-微球蛋白、转铁蛋白、CA153、CA125、可溶性白介素2受体(sIL-2R)水平均升高,而血小板计数(PLT)降低,差异具有统计学意义(P<0.05... | zh-cn |
pair_34105471 | To summarize the clinical and Laboratory characteristics of patients with multiple myeloma (MM) and analyze the prognostic factors. Two hundred MM patients were retrospectively analyzed for the following parameters, including peripheral blood, bone marrow morphology, cytogenetics, clinical staging, and response to the ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 多发性骨髓瘤患者的临床特征及预后因素分析. 总结多发性骨髓瘤(MM)患者的临床及实验室特征资料并分析影响预后的因素. 回顾性分析苏州大学附属第一医院收治的200例初诊MM患者外周血、骨髓象、细胞遗传学、临床分期、疗效等方面的特点,总结影响患者总体生存(OS)的相关因素. 200例MM患者按照初诊时骨髓涂片获取的骨髓浆细胞百分比(BMPC%)分为3组,<10%组占37.0%(74例),10%-50%组占37.5%(75例),>50%组占25.5%(51例);相较于其他两组,<10%组的患者各项临床分期级别偏低,13q14缺失、t(11;14)阳性率低,对化疗更敏感,3年OS率更高。单因素分析结果显示,初诊时年龄≤55岁、BMPC%<1... | zh-cn |
pair_34105472 | To explore the influence of controlling nutritional status (CONUT) score on the prognosis of newly diagnosed patients with multiple myeloma (MM). The clinical data 119 patients with MM who were diagnosed according to the international myeloma diagnostic criteria in Lanzhou University Second Hospital from April 2010 to ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | CONUT评分对多发性骨髓瘤患者预后的影响. 探讨营养状况(CONUT)评分对初诊多发性骨髓瘤(MM)患者预后的影响. 收集并回顾性分析2010年4月至2018年10月在兰州大学第二医院根据国际骨髓瘤诊断标准明确诊断为MM的119例患者的临床资料,分析患者的年龄、性别、MM分型、淋巴细胞绝对数、中性粒细胞绝对数、单核细胞绝对数、血红蛋白、血小板数、β<sub>2</sub>-微球蛋白、乳酸脱氢酶、白蛋白、球蛋白、胆固醇、血肌酐等临床指标与CONUT评分之间的关系,探讨上述指标对初诊MM患者的预后价值。使用SPSS 25.0软件进行统计学分析。用Kaplan-Meier曲线计算各亚组之间无进展生存期(PFS)、总生存期(OS),生存曲... | zh-cn |
pair_34105473 | To analyze one case of multiple myeloma (MM) initially presenting cold agglutinin syndrome (CAS), so as to improve clinical understanding and screening of this disease. The clinical data, laboratory examination, bone marrow result, diagnosis and treatment of the patient were analyzed and summarized to provide ideas and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 以冷凝集素综合征为首发表现的多发性骨髓瘤患者的早期诊断. 分析1例以冷凝集素综合征(CAS)为首发表现起病的多发性骨髓瘤(MM)患者的临床资料,以提高对该病的认识和临床筛查. 对患者一般资料、实验室检查及骨髓结果、治疗方案做阐述和总结,为MM继发CAS的早期诊治提供思路. 患者出现乏力、血尿、黄疸、全身网状青斑等临床表现为MM继发CAS所致,与一般的雷诺现象不同,根据骨髓象及免疫固定电泳等明确诊断为IgMκ型MM,给予BAD方案化疗3个疗程,并加强保暖支持治疗后,贫血纠正,M蛋白减低,冷凝集现象明显减轻,疗效评估达非常好的部分缓解. 以CAS为首发表现的MM极为罕见,临床易漏诊。因此早期确诊及个体化治疗显得格外重要,需要临床医生进一... | zh-cn |
pair_34105475 | To investigate the effects of autophagy inhibitor ROC-325 and its combination with bortezomib on the proliferation, apoptosis and autophagy of multiple myeloma cell lines. Multiple myeloma cells were treated with ROC-325 at different concentration. The cell proliferation was detected by CCK-8. Apoptosis was determined ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 自噬抑制剂ROC-325抗多发性骨髓瘤作用的研究. 探讨自噬抑制剂ROC-325对人多发性骨髓瘤细胞株增殖、凋亡、自噬的影响及其与硼替佐米联合用药的细胞学效应. 不同浓度的ROC-325作用于骨髓瘤细胞,用CCK-8法检测药物对细胞增殖的作用,用Caspase-3/7、Caspase-9活性测定法检测药物对细胞凋亡的影响,用单丹磺酰戊二胺染色观察自噬小体数量,Western blot检测各组细胞凋亡相关蛋白(PARP和Caspase-3)和自噬相关蛋白(P62、Beclin-1和LC3A/B)的表达情况,用CCK-8法检测ROC-325联合硼替佐米对硼替佐米耐药细胞株的抑制作用. ROC-325可呈剂量依赖性抑制RPMI 8226、... | zh-cn |
pair_34105478 | To investigate the effect of complement C3 on the prognosis of patients with multiple myeloma (MM), and to establish a predictive model to evaluate the overall survival. Eighty newly diagnosed MM patients were enrolled, and clinical characteristics, such as sex, age, platelet count, white blood cell count, ISS stage, F... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 补体C3水平对多发性骨髓瘤患者生存的影响及模型预测. 探讨多发性骨髓瘤(MM)患者补体C3水平对其生存预后的影响,并以此构建生存模型预测患者的长期生存。方法:。结果:。结论:。. 回顾性分析80例初治MM患者的性别、年龄、血小板计数、白细胞数、ISS分期、FISH 、患者血清kappa轻链、lammda轻链、补体C3、C4水平等指标,通过Cox回归生存分析模型,对影响患者生存的危险因素进行单因素以及多因素分析。以补体C3水平为基础,构建疾病生存预测模型(Nomogram图). MM患者平均年龄(63.15±10.41)岁,其中男36 例,女44例。中位总生存期(OS)36.3个月,中位无进展生存期(PFS)35.2个月,3年OS率为... | zh-cn |
pair_34105477 | To summarize and compare the clinical baseline characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS), primary light chain amyloidosis (pAL), multiple myeloma (MM), or MM with concurrent amyloidosis, especially the differences in cytogenetic abnormalities. The clinical data of 15 cas... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | MGUS、原发性轻链型淀粉样变、MM及MM继发淀粉样变性患者的临床分析. 总结并比较意义未明的单克隆丙种球蛋白血症(MGUS)、原发性轻链(pAL)型淀粉样变、多发性骨髓瘤(MM)以及MM继发淀粉样变性患者的临床基线特点,尤其是细胞遗传学异常的差异. 回顾性分析和比较2006年2月至2019年8月于中国医学科学院血液病医院淋巴瘤诊疗中心就诊,并完善了细胞遗传学异常检测的15例MGUS、34例pAL、842例MM和23例MM继发淀粉样变性患者的临床资料. 细胞遗传学统计显示,4组(MGUS vs pAL vs MM vs MM继发淀粉样变性)中t(11;14)易位发生率分别为0%、33.3%、16.4%和15.8%(P=0.037);... | zh-cn |
pair_34105481 | To investigate the clinical characteristics and prognosis of patients with medium and high risk myelodysplastic syndrome (MDS). 97 MDS patients above the age of 60 treated in Nanfang Hospital, Southern Medical University from February 2011 to August 2020 were enrolled. The clinical characteristics and prognosis of the ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 老年中高危骨髓增生异常综合征患者的临床特点及预后研究. 探讨老年中高危骨髓增生异常综合征(MDS)患者的临床特点及预后. 回顾性分析2011年2月至2020年8月在南方医科大学南方医院就诊的97例年龄≥60岁、IPSS-R危险分层为中危/高危/极高危MDS患者的临床特点及预后情况。根据采取治疗方案的不同,将患者分为移植、化疗和其他治疗3组,分析评估不同治疗组患者之间疗效的差别. 老年中高危MDS患者以MDS伴原始细胞增多型(MDS-EB)为主,47.4%的患者合并染色体核型异常,其中复杂核型(≥3个)占23.7%。97.3%的患者至少存在一种基因突变,TP53突变在老年中高危MDS患者中检出率近20%。多因素分析显示,IPSS-R危... | zh-cn |
pair_34105482 | To explore the value of red cell distribution width (RDW), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and hemoglobin (Hb) A2 combined determination scheme for screening thalassemia. The RDW levels of thalassemia group and healthy control group were detected and compared. The efficiency of RDW for ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | RDW筛查地中海贫血诊断界值的建立及其与MCV、MCH、HBA <sub>2</sub>联合筛查的价值. 探讨红细胞分布宽度(RDW)与红细胞平均体积(MCV)、平均红细胞血红蛋白含量(MCH)、血红蛋白(Hb)A2联合筛查方案在地中海贫血(简称地贫)筛查中的应用价值. 检测地贫患者和体检健康者(健康对照组)的RDW水平,比较两组RDW水平变化。绘制受试者工作曲线(ROC),计算约登指数,评价RDW的诊断性能,建立RDW筛查地贫诊断界值。另外选取621例疑似地贫患者,设置3组筛查方案,分别为MCV+MCH+HBA <sub>2</sub>、MCV+MCH+RDW(>16.0)+HBA <sub>2</sub>和MCV+MCH+RDW... | zh-cn |
pair_34105483 | To observe and compare the therapeutic effects of hydroxypropyl chitosan ferrous ion complex solution and ferrous sulfate solution in iron deficiency anemia rats and their effects on gastric mucosa. Seven rats were randomly selected from thirty five SPF grade SD rats as control group, and were fed with normal diet, dis... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 羟丙基壳聚糖亚铁离子配合物和硫酸亚铁对缺铁性贫血大鼠治疗的对比研究. 观察比较羟丙基壳聚糖亚铁离子配合物和硫酸亚铁对缺铁性贫血大鼠的治疗效果及对其胃黏膜的影响. 从35只SPF级别SD大鼠中随机选取出7只设为正常对照组(E),给予普通饲料和蒸馏水喂养。其余SD大鼠采用低铁饲料和蒸馏水喂养,加尾静脉连续放血法进行缺铁性贫血建模。建模成功后,随机分成4组,分别为胃黏膜空白对照组(A)、缺铁性贫血对照组(B)、硫酸亚铁组(C)、羟丙基壳聚糖亚铁离子配合物(HPCTS-Fe<sup>2+</sup>)组(D),A组处死并取胃组织制作病理切片,E组继续予普通饲料和蒸馏水喂养,B、C、D组继续予低铁饲料和蒸馏水,另外C组和D组分别予硫酸亚铁溶液... | zh-cn |
pair_34105484 | To analyze the gene defect types and distribution characteristics of α- and β-thalassemia in Lingui District of Guilin City, Guangxi, so as to provide scientific basis for genetic consultation and prevention measures. A total of 6 496 suspected cases for screening the thalassemia during physical examination, premarital... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 桂林市临桂地区地中海贫血基因缺陷类型分析. 分析广西桂林市临桂地区人群α和β地中海贫血基因类型及分布特征,为遗传咨询及防治措施提供科学依据. 以2016年5月—2019年10月在桂林医学院第二附属医院进行体检、婚检、孕检和住院期间疑似地中海贫血的患者共计6 496例作为分析对象,采用Gap-PCR、PCR-RDB及DNA测序技术检测并分析α、β地中海贫血阳性病例的基因类型及其构成比. 在6 496例就诊人群中检出地中海贫血基因阳性携带者1 363例,总阳性率20.98%。其中缺失型α地贫基因单缺失677例、双缺失26例;非缺失型α地贫基因突变115例、α缺失加突变型4例, α地贫基因阳性率为12.66%;出现的11种α地贫基因异常以... | zh-cn |
pair_34105485 | To understand the genotypes and distribution characteristics of thalassemia in Baise, Guangxi Zhuang Autonomous Region, to provide references for the prevention and diagnosis of thalassemia in the region and improve the quality of eugenics. 3 482 pregnant women and their spouses from January 2019 to August 2019 in Bais... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 广西百色地区地中海贫血的基因诊断回顾分析. 了解广西百色地区地中海贫血的基因型及分布特征,为本地区的地中海贫血预防和诊断提供参考,提高优生质量. 选择2019年1至8月在百色市妇幼保健院做产前基因诊断的3 482例孕妇及其配偶,通过Gap-PCR和PCR与DNA反向点杂交进行α、β地中海贫血基因检测,确认地中海贫血基因携带者,并对其进行统计学分析. 2 260例(64.90%)样本确认携带地中海贫血基因,其中,α地中海贫血1 459例(64.56%),β地中海贫血617例(27.30%),α复合β地中海贫血184例(8.14%)。1 459例α地中海贫血中,以--SEA/αα(637例,43.66%)、-α3.7/ αα(306例,... | zh-cn |
pair_34105486 | To investigate the correlation between pretransplant serum ferritin (SF) level and prolonged or prolonged isolated thrombocytopenia (PT) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 35 patients with PT after allo-HSCT were retrospectively analyzed, and 35 patients were matc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 异基因造血干细胞移植患者血清铁蛋白水平在移植后血小板减少中的临床意义. 探讨血清铁蛋白水平(SF)在异基因造血干细胞移植(allo-HSCT)后血小板减少中的临床意义. 回顾性分析本院35例移植后血小板减少患者临床资料及移植情况,并从血小板计数正常的424例患者中按照年龄及性别匹配方式选取35名同时期移植患者作为对照,参照移植前SF水平,通过卡方检验和Fisher精确检验,以及单因素、多因素Logistic回归分析分析危险因素。采用Kaplan-Meier模型估算生存曲线以探讨其临床意义,并应用ROC曲线验证SF的预测效能. 移植后血小板减少组与对照组相比,移植前SF水平显著增高(P=0.001)。多因素分析结果显示,移植前SF水平... | zh-cn |
pair_34105488 | To explore the influencing factors in children with chronicity immune thrombocytopenia (ITP), and to provide basis for judging the prognosis and treatment in children with ITP. The clinical data of children with ITP admitted to The Second Affiliated Hospital of Anhui Medical University in the past 5 years were retrospe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 儿童免疫性血小板减少症病程慢性化影响因素的研究. 探讨儿童原发免疫性血小板减少症(ITP)慢性化进程中的相关影响因素,为临床判断疾病转归及治疗提供参考依据. 回顾性分析安徽医科大学第二附属医院近5年收治的ITP患儿初诊时的临床资料,并随访1年以上,按纳入标准选取符合要求的病例328例,通过病历系统检索、门诊及电话随访等方式收集可能与ITP慢性化进程相关的临床指标,通过单因素、多因素logistic分析得出影响患儿预后的独立影响因素,并评估其对ITP患儿预后的预测价值. 328例ITP患儿中,新诊断ITP 208例(nITP, 64%),持续性ITP 54例(pITP, 16%),慢性ITP 66例(cITP, 20%),1年内缓解率... | zh-cn |
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