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pair_34105489 | To investigate the causes, treatment options and outcomes of immune thrombocytopenia (ITP) patients with splanchnic venous thrombosis (SVT). The clinical diagnosis, treatment and outcomes data of one 26-year-old male ITP patient with SVT as initial manifestation were collected. The possible causes and treatment options... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 以SVT为首发表现免疫性血小板减少症患者的治疗选择及临床意义. 探讨免疫性血小板减少症（ITP）患者伴发内脏静脉血栓（SVT）的成因、治疗选择及转归. 采集一例26岁以SVT为首发表现的ITP男性患者的临床诊断、治疗及转归资料，结合文献探讨其可能的成因及治疗选择. 患者多次血常规提示，血小板（37-38）×10<sup>9</sup>/L，嗜酸粒细胞（EOS）46.9%-50%。B超和CT检查均提示，肝门静脉及其分支、脾静脉血栓形成，诊断为ITP伴SVT。经积极病因治疗及减低剂量低分子肝素（LMWH）抗凝，患者已痊愈. ITP伴发较大范围SVT实属罕见，治疗难度大。临床上需关注一过性高EOS可能引起的血栓风险，应积极治疗本病，平衡抗... | zh-cn |
pair_34105490 | To investigate the biological function of Cysteine rich (CysR) domain of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 (ADAMTS13) on cleavage of von Willebrand factor (vWF) and provide experimental evidence for exploring the pathogenesis of thrombotic thrombocytopenic purpura (TTP). The six am... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 血管性血友病因子裂解酶CysR结构域生物学功能的研究. 研究血管性血友病因子裂解酶（ADAMTS13）富含半胱氨酸（CysR）结构域在血管性血友病因子（vWF）裂解中的生物学功能，为探明血栓性血小板减少性紫癜（TTP）的发病机制提供实验证据. 利用点突变技术对ADAMTS13 CysR结构域中的EDGTLS氨基酸残基进行基因突变，制备质粒，表达并提纯蛋白。1% SeaKem HGT琼脂糖凝胶分离后用Western blot方法观察野生型和突变型ADAMTS13在变性条件或剪切应力作用下对底物vWF的裂解活性. 成功构建了ADAMTS13突变体质粒（M1：Glu515Ala；M2：Asp516Ala；M3：Gly517Ala；M4：T... | zh-cn |
pair_34105491 | To explore the effects of hematocrit (HCT) on the parameters of thromboelastography (TEG) in healthy adults, so as to judge coagulation and fibrinolysis more accurately. Three hundred and ninety-three healthy adults examined in Chengdu 363 Hospital Affiliated to Southwest Medical University from May 2018 to May 2019 we... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 健康成人红细胞比容对血栓弹力图检测参数的影响. 探讨健康成人红细胞比容（HCT）对血栓弹力图（TEG）检测参数的影响，以期更加准确地判断凝血和纤溶状态. 选取2018年5月- 2019年5月在西南医科大学附属成都三六三医院检查的健康成人393例，同时检测HCT和TEG，比较高HCT组与低HCT组之间TEG各参数的差异，分析HCT与TEG各参数之间的相关性，比较高原地区与平原地区健康成人的TEG各参数之间存在的差异. TEG各参数中，与低HCT组比较高HCT组的R和K明显升高，Angle、MA、CI明显降低，差异有统计学意义（P<0.05），LY30和EPL在两组之间无明显差异（P>0.05）。R、K与HCT呈正相关（r=0.112、... | zh-cn |
pair_34105492 | To investigate the recent HIV-1 infections of the blood donors in Fuzhou zone. The positive HIV antibody confirmatory samples in Fuzhou zone from 2012 to 2016 were collected and tested by LAg-Avidity EIA, and HIV long-term infections or recent infections were determined. 405 371 cases of blood donors were tested in the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 福州地区无偿献血人群HIV-1新近感染情况的回顾性分析. 了解福州地区无偿献血人群HIV-1新近感染的情况. 收集2012至2016年福州地区HIV抗体确证阳性标本，对所有标本采用限制性抗原亲和力酶联免疫法检测，以确定新近感染或既往感染的情况. 2012至2016年共对405 371份无偿献血者血液标本进行HIV项目检测，共收集HIV抗体确证阳性标本94份，经检测判定为新近感染标本共35份，每年HIV-1新近感染率分别为1.326‰、0.845‰、0.694‰、1.148‰和0.364‰，均值为0.863‰。94份确证阳性的标本中，初次献血者与重复献血者分别为58和36例，其中判定为新近感染标本分别为17份和18份，新近感染例数分别... | zh-cn |
pair_34105493 | To investigate the indentification method of samples mistyped as O phenotype and to explore the precision transfusion strategy. The blood samples from donors and patients admitted in our center from 2018 to 2019 was collected. The samples with O phenotype suspected subtypes were further determined by tube test, adsorpt... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 误判O型的疑难血型鉴定及安全输血策略的研究. 综合探讨多种误判O型的疑难血型鉴定及安全输血策略. 收集2018-2019年本中心接收的无偿献血者和临床患者疑难血型复检标本，对表型为O型但疑似亚型标本使用试管法、吸收放散法等进一步验证；并采用分子生物学方法对受检者的相关血型基因进行检测. 14例表型被误判为O型的受检者中，共鉴定出11种基因型，其中无偿献血者3例，ABO血型基因型分别为Ael02/O02、Bel03/O02及1例类孟买B101/O02（FUT1: h3h3; FUT2: Se<sup>357</sup>Se<sup>357</sup>）；临床患者11例，ABO血型基因型分别为Ael02/O01、Ael02/O02（2例... | zh-cn |
pair_34105495 | To analyze the dynamic molecular expression characteristics of single cell RNA binding proteins (RBPs) in the development of mouse embryonic hematopoitic stem cells (HSCs), and obtain the functional research target RNA splicing factor--Mbnl1, to clarify the function of Mbnl1 involved in regulating mouse embryonic HSC d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | RNA结合蛋白Mbnl1调控小鼠胚胎造血干细胞发育功能的研究. 分析小鼠胚胎造血干细胞（HSC）发育全程的单细胞RNA结合蛋白（RBPs）动态分子表达特征，筛选获得功能研究靶标RNA剪接因子--Mbnl1，并阐明Mbnl1参与调控小鼠胚胎HSC发育的功能. 生物信息学深入分析小鼠胚胎HSC发育全程的单细胞转录组数据，获得HSC发育全程的单细胞RBP动态分子表达图谱。结合差异分析以及文献调研筛选获得Mbnl1。利用CRISPER/Cas9技术构建Mbnl1基因敲除小鼠模型，采用甲基纤维素半固体培养体系,针对E11.5的Mbnl1<sup>+/+</sup>和Mbnl1<sup>-/-</sup> 两种基因型小鼠胚胎的主动脉-性腺-中肾... | zh-cn |
pair_34105496 | To explore the kinetics of infiltrated T cell in murine acute graft-versus-host disease (aGVHD) target organs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its relationship with tissue pathological damage and aGVHD progress. Male C57BL/6 (H-2K<sup>b</sup>) mice at age of 8-10 weeks were selec... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | GVHD靶器官中浸润CD3<sup>+</sup> T细胞动态变化与组织损伤关系. 探讨T细胞在小鼠异基因造血干细胞移植术后急性移植物抗宿主病（aGVHD）靶器官中的浸润及其变化趋势，并研究其与靶组织病理损伤和aGVHD进展的相关性. 以8-10周龄雄性C57BL/6（H-2K<sup>b</sup>）小鼠为供 鼠，获取骨髓细胞、脾单个核细胞，将10-12周龄雄性BALB/c（H-2K<sup>d</sup>）小鼠经7.5 Gy全身照射后作为受鼠进行移植。受鼠随机分为异基因骨髓移植（BMT）组和异基因骨髓移植联合脾细胞输注诱导aGVHD（BMT+T）组。移植后每天观察小鼠状态，动态检测各组小鼠体重变化及临床评分；HE染色观察aGVH... | zh-cn |
pair_34105497 | To establish the aGVHD mouse model，and investigate the regulatory effect and its mechanism of low-dose GSI combined with BMSC on aGVHD mice. C57BL/6 (H-2b) and BALB/c (H-2d) were selected as donor and recipient of allogeneic transplantation to establish the aGVHD mouse model. BALB/c mice were randomly divided into 6 gr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | γ分泌酶抑制剂联合BMSC对小鼠急性移植物抗宿主病的影响. 建立aGVHD小鼠模型，探讨低剂量γ分泌酶抑制剂（GSI）联合BMSC对小鼠aGVHD的调控作用及其机制. 选择C57BL/6（H-2b）→BALB/c（H-2d）作为异基因移植供、受体，建立aGVHD模型。BALB/c受鼠随机分为6组，分别为照射后输注骨髓细胞组（BM）, 照射后输注骨髓细胞与脾细胞组（BM+SC）, 照射后输注骨髓细胞与脾细胞+DMSO组（BM+SC+DMSO）（移植对照组）, 照射后输注骨髓细胞与脾细胞+GSI组（BM+SC+GSI）, 照射后输注骨髓细胞与脾细胞及骨髓基质细胞组（BM+SC+BMSC）, 照射后输注骨髓细胞与脾细胞及骨髓基质细胞+GS... | zh-cn |
pair_34105499 | To retrospectively analyze the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in hematopoietic stem cell mobilization in 71 normal healthy donors for allogeneic hematopoietic stem cell transplantation (allo-HSCT). From March 2018 to July 2019, 71 patients received... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | PEG-rhG-CSF在71例allo-HSCT健康供者HSC动员中的有效性及安全性分析. 回顾性分析聚乙二醇化重组人粒细胞集落刺激因子（PEG-rhG-CSF）在71例异基因造血干细胞移植（allo-HSCT）健康供者造血干细胞（HSC）动员中的有效性及安全性. 选择2018年3月至2019年7月在西部战区总医院接受allo-HSCT的HSC供者71例，采用PEG-rhG-CSF 12 mg单次皮下注射，d 4检测CD34<sup>+</sup>细胞数，根据细胞数于d 4或d 5采集干细胞。采集成功标准为CD34<sup>+</sup>细胞≥2×10<sup>6</sup>/kg，采集优良标准为CD34<sup>+</sup>细胞... | zh-cn |
pair_34105500 | To investigate the clinical correlation of expression level changes of miR-181b and miR-194 to the pathogenesis of acute graft-versus-host disease (aGVHD), and determine plasma miR-181b and miR-194 as the potential biomarkers for aGVHD. The plasma samples were collected from 31 patients who underwent allogeneic hematop... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 血浆miR-181b和miR-194作为急性移植物抗宿主病诊断及疗效评价的标志物的研究. 研究血浆中miR-181b和miR-194的水平变化与异基因造血干细胞移植后发生急性移植物抗宿主病（aGVHD）的关联性，确定新的aGVHD诊断及预测标志物. 采用qRT-PCR方法检测31例接受异基因造血干细胞移植的患者移植前、移植后15 d以及发生aGVHD时血浆中miR-181b和miR-194表达水平变化，利用ROC曲线及曲线下面积分析移植后第15天miR-181b和miR-194的表达量作为aGVHD早期诊断标志物的特异性和敏感性. 发生aGVHD时患者血浆miR-181b和miR-194表达水平较移植前显著上调（P＜0.05），且在... | zh-cn |
pair_34105503 | To analyze and predict the effect of coronavirus infection on hematopoietic system and potential intervention drugs, and explore their significance for coronavirus disease 2019 (COVID-19). The gene expression omnibus (GEO) database was used to screen the whole genome expression data related with coronavirus infection. ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 冠状病毒感染对造血系统影响及潜在干预药物的生物信息学分析及其对新型冠状病毒肺炎的意义. 分析预测冠状病毒感染对造血系统影响及潜在干预药物，探索其对新型冠状病毒肺炎（COVID-19）的意义. 利用基因表达数据库（GEO），筛选冠状病毒感染相关的全基因组表达数据，使用R语言包对数据进行差异表达分析及KEGG和GO富集分析。使用STRING在线分析网站进行PPI网络分析，筛选出核心基因。再应用自主研发的表观精准治疗预测平台（EpiMed）进行疾病、药物和关联靶基因的分析. 检索到1个符合标准的数据库，来源于SARS冠状病毒，共筛选出差异基因3 606个，其中表达上调2 148个，下调1 458个。GO富集主要与病毒感染、造血调节、细胞趋... | zh-cn |
pair_34105504 | Primary immune thrombocytopenia (ITP) is a blood system disease mediated by autoimmune mechanism. Currently, the goal of treatment for primary ITP is to keep patients' peripheral platelet count at a safe level to prevent severe bleeding. Recently, avatrombopag and fostamatinib have been approved by the FDA for the trea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 原发免疫性血小板减少症的治疗进展. 原发免疫性血小板减少症（ITP）是一种由自身免疫机制介导的血液系统疾病。当前，原发ITP的治疗目标是保证患者外周血小板数处于一个安全水平，以防止患者出现严重的出血症状。近两年，新型药物阿伐曲泊帕、福坦替尼已被美国食品药品监督管理局批准用于成人ITP的治疗，而rozanolixizumab、efgartigimod、PRTX-100、地西他滨以及阿托伐他汀等药物也在早期的临床试验中展现了一定的疗效。本篇综述将就当前用于成年原发ITP患者临床治疗的各类方法进行概述，并讨论近年来各新型疗法的研究进展. | zh-cn |
pair_34105505 | Novel coronavirus disease 2019 (COVID-19) has started to erupt in Wuhan since December 2019, and then the cases of COVID-19 increased rapidly, the epidemic situation spreaded to most area of China. Owing to the lack of specific drugs at present, convalescent plasma therapy becomes an alternative treatment. However, the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 康复期血浆输注对暴发性病毒性传染病的治疗作用. 自2019年12月开始出现新型冠状病毒感染肺炎（COVID-19）病例以来，数月内确认病例数迅速增加，疫情扩散至国内大部分地区。鉴于此次COVID-19暴发时缺乏明确的特效药物，新型冠状病毒感染肺炎患者康复期血浆治疗成为一种可选择的治疗方案。然而，对于其中供体的选择、适合治疗的患者、治疗的时机选择、输注剂量以及优势和缺点等不甚明确。本文就康复期血浆治疗在之前数种病毒性传染病流行期的临床研究以及病例报告中提示的以上问题作一综述，期望能对此次COVID-19的治疗提供线索. | zh-cn |
pair_34105507 | Acute intestinal graft-versus-host disease is a refractory disease which can affect implantation and become a threat to life in severe cases. Autophagy is an intracellular degradation pathway necessary for maintaining cellular energy homeostasis. In recent years, a large number of studies have found that it is closely ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 自噬在急性肠道移植物抗宿主病中的研究进展. 急性肠道移植物抗宿主病治疗困难，严重者会影响植入并危及患者生命。自噬是维持细胞能量稳态所必需的细胞内降解途径，近年来大量研究发现其与急性肠道移植物抗宿主病的发生发展密切相关，可能的主要机制是，预处理及输注供者细胞后炎性因子风暴诱发肠道免疫耐受稳态失调，异常的氧化应激损伤肠黏膜屏障，从而经由mTOR自噬信号通路、线粒体自噬相关异常等途径引发急性移植物抗宿主病的肠道排异. | zh-cn |
pair_34105508 | Emerging data have demonstrated that bone marrow mesenchymal stem cells (MSCs) play important roles in the progression of myelodysplastic syndrome (MDS). Experiments in vitro have showed that MSCs derived from MDS patients (MDS-MSC) exhibit the biological characteristics of cell senescence. Although the underlying mech... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 骨髓增生异常综合征患者来源的骨髓间充质干细胞衰老机制的研究进展. 越来越多的研究表明，骨髓间充质干细胞（MSC）在骨髓增生异常综合征（MDS）的进展过程中发挥了重要作用。体外实验显示，MDS患者的MSC（MDS-MSC）展现出细胞衰老的生物学特点。尽管调控细胞衰老的潜在机制有待深入研究，但现有的研究表明MDS-MSC细胞衰老的机制具有显著的异质性。加深对MDS-MSC衰老潜在机制的认识有助于促进MDS新治疗靶点的探索。因此，本文对MDS-MSC细胞衰老相关端粒长度内在改变、DNA甲基化状态、氧化应激、调控细胞衰老的基因和信号通路方面的研究进展进行总结. | zh-cn |
pair_34105772 | This study explores the lived experiences of Israeli parents of transgender young adults, depicting gender diversity as a family-relational phenomenon. The analysis of 18 in-depth, semi-structured interviews with Israeli parents of trans young adults suggests that the parents' experiences were characterized by a dialec... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 这项研究探讨了变性年轻人的以色列父母的生活经历，将性别多样性描述为一种家庭关系现象。本研究对18个变性年轻人的以色列父母进行了深入半结构性访谈，访谈文本分析表明，父母的经历具备脆弱感和抗挫力两方面之间的辩证关系。父母的脆弱性是由他们作为少数群体的社会定位以及他们的社会政治环境决定的，而他们应对这些困难的能力增强了他们的复原力。当父母通过创造意义、社会支持和积极的行动来发展他们的抗挫力时，他们在深感脆弱的同时也获得了新的主观能动性，这表明脆弱和复原力不是客观的、相反的二元对立，而是通过微观和宏观因素的交织不断构建的动态的种类。. | zh-cn |
pair_34105772 | This study explores the lived experiences of Israeli parents of transgender young adults, depicting gender diversity as a family-relational phenomenon. The analysis of 18 in-depth, semi-structured interviews with Israeli parents of trans young adults suggests that the parents' experiences were characterized by a dialec... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | En este estudio se analizan las experiencias vividas por padres israelitas de adultos jóvenes transgénero y se describe la diversidad de género como fenómeno relacional familiar. El análisis de 18 entrevistas profundas semiestructuradas con padres israelitas de jóvenes transgénero indica que las experiencias de los pad... | es |
pair_34105777 | There are few clinically valid tools that can be used to assess potential parent-infant relational risk. This study describes the development and initial validation of the assessment of representational risk (ARR) coding system to be applied to the parent development interview (Slade, A., Aber, J. L., Bresgi, I., Berge... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 很少有临床上有效的工具可以用来评估潜在的亲子关系风险。本研究描述了“表现风险评估” (ARR) 编码系统的开发和初步验证, 该系统将应用于“父母发展访谈” (PDI; Slade et al., 2004) , 以评估看护者对婴儿、作为父母的自己及其关系的表现的潜在风险。ARR是在英国的三个样本中开发和验证的。文献回顾为10项选择提供了依据。它具有三要素结构, 以用于开发分量表:敌对, 无助和自恋型看护表现。各分量表和总风险评分在区分高、低风险样本时具有良好的效标效度, 并与测量的父母心理病理学、亲子互动数据具有良好的共时效度。ARR是一个用于识别早期依恋关系中的风险的潜在有价值的编码系统。. | zh-cn |
pair_34105777 | There are few clinically valid tools that can be used to assess potential parent-infant relational risk. This study describes the development and initial validation of the assessment of representational risk (ARR) coding system to be applied to the parent development interview (Slade, A., Aber, J. L., Bresgi, I., Berge... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Il existe peu d'outils cliniquement valables qui peuvent être utilisés pour évaluer le risque relationnel potentiel parent-nourrisson. Cette étude décrit le développement et la validation initiale du système de codage Evaluation du Risque Représentationnel (abrégé ici ERR en français) destiné à être appliqué à l'Entret... | fr |
pair_34105777 | There are few clinically valid tools that can be used to assess potential parent-infant relational risk. This study describes the development and initial validation of the assessment of representational risk (ARR) coding system to be applied to the parent development interview (Slade, A., Aber, J. L., Bresgi, I., Berge... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Das „Assessment of Representational Risk“ (ARR): Entwicklung und psychometrische Eigenschaften eines neuen Kodierungssystems zur Bewertung von Risiken in der Eltern-Kind-Beziehung Es gibt nur wenige klinisch valide Instrumente, die zur Einschätzung eines potentiellen Eltern-Säuglings-Beziehungsrisikos verwendet werden ... | de |
pair_34105777 | There are few clinically valid tools that can be used to assess potential parent-infant relational risk. This study describes the development and initial validation of the assessment of representational risk (ARR) coding system to be applied to the parent development interview (Slade, A., Aber, J. L., Bresgi, I., Berge... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Hay pocas herramientas clínicamente válidas que pueden usarse para evaluar los posibles riesgos en la relación progenitor-infante. Este estudio describe el desarrollo y la convalidación inicial de la Evaluación del Riesgo Representacional (ARR), un sistema de codificación para aplicarse a la Entrevista del Desarrollo d... | es |
pair_34105788 | Among adolescents, Latinas are at an increased risk of experiencing suicidal ideation and attempts compared to non-Hispanic, White youth. Previous research indicates that family dynamics are influential as both protective and risk factors. Although significant research has been conducted over the past several decades e... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在青少年中，与非西班牙裔的白人青年相比，拉美裔青少年的自杀意念和有自杀企图的风险更高。以前的研究表明，家庭动态既是保护因素也是风险因素。尽管在过去的几十年里，对母女关系进行了大量的研究，但很少有研究对拉丁裔青少年中有自杀企图的人群的父女关系进行研究。与母女关系相比，拉丁裔的父亲和女儿之间的关系动态既相似又有独特性。鉴于此，有必要进行深入分析。为了解决这个研究的空白问题，本研究使用了二元主题分析来描述父女关系（N = 10对，20个单独访谈）和父亲对他们的拉丁裔女儿自杀企图的反应。研究结果分析得出了三个主题（a）动态接近，描述了父亲和女儿之间在情感和身体上的亲近程度的变化；（b）作为保护人的父亲，描述了父亲在保护或未能保护女儿方面的角... | zh-cn |
pair_34105788 | Among adolescents, Latinas are at an increased risk of experiencing suicidal ideation and attempts compared to non-Hispanic, White youth. Previous research indicates that family dynamics are influential as both protective and risk factors. Although significant research has been conducted over the past several decades e... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Entre las adolescentes, las latinas corren un mayor riesgo de tener ideación e intentos suicidas en comparación con las jóvenes blancas no hispanas. Hay investigaciones previas que indican que la dinámica familiar influye tanto como factor protector como de riesgo. Aunque se ha investigado bastante durante las últimas ... | es |
pair_34105850 | Hyperbaric oxygen therapy (HBOT) has been beneficial in treating people with nocardiosis. This report describes Nocardia spp. affecting a cat, with lesions confined to the skin. To the best of the authors' knowledge, this is the first report of HBOT, combined with amikacin, used to successfully treat feline cutaneous n... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 高压氧治疗(HBOT)对治疗诺卡菌病的病人有益。本报告描述了诺卡菌感染的猫病例，病变局限于皮肤。据作者所知，这是HBOT联合阿米卡星成功治疗猫皮肤诺卡菌病的首次报道。. | zh-cn |
pair_34105850 | Hyperbaric oxygen therapy (HBOT) has been beneficial in treating people with nocardiosis. This report describes Nocardia spp. affecting a cat, with lesions confined to the skin. To the best of the authors' knowledge, this is the first report of HBOT, combined with amikacin, used to successfully treat feline cutaneous n... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Le traitement à l’oxygène hyperbar (HBOT) a été bénéfique pour le traitement de la nocardiose chez l’homme. Cet article décrit un chat atteint par Nocardia spp. avec des lésions cantonnées à la peau. A la connaissance des auteurs, ceci est la première description de HBOT, combinée à l’amikacine, utilisée pour traiter a... | fr |
pair_34105850 | Hyperbaric oxygen therapy (HBOT) has been beneficial in treating people with nocardiosis. This report describes Nocardia spp. affecting a cat, with lesions confined to the skin. To the best of the authors' knowledge, this is the first report of HBOT, combined with amikacin, used to successfully treat feline cutaneous n... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die hyperbare Sauerstofftherapie (HBOT) hat sich bei der Behandlung von Menschen mit einer Nocardiose als günstig erwiesen. Dieser Fallbericht beschreibt eine Nocardia spp. Infektion bei einer Katze mit Veränderungen, die auf die Haut beschränkt waren. Nach bestem Wissen der Autoren handelt es sich hierbei um den erste... | de |
pair_34105850 | Hyperbaric oxygen therapy (HBOT) has been beneficial in treating people with nocardiosis. This report describes Nocardia spp. affecting a cat, with lesions confined to the skin. To the best of the authors' knowledge, this is the first report of HBOT, combined with amikacin, used to successfully treat feline cutaneous n... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A oxigenoterapia hiperbárica (OHB) tem sido benéfica no tratamento de pessoas com nocardiose. Este relatório descreve um caso Nocardia spp. afetando um gato, com lesões limitadas à pele. De acordo com o conhecimento dos autores, este é o primeiro relato do uso de OHB, combinado com amicacina, para tratar com sucesso a ... | pt |
pair_34105850 | Hyperbaric oxygen therapy (HBOT) has been beneficial in treating people with nocardiosis. This report describes Nocardia spp. affecting a cat, with lesions confined to the skin. To the best of the authors' knowledge, this is the first report of HBOT, combined with amikacin, used to successfully treat feline cutaneous n... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La terapia con oxígeno hiperbárico (HBOT) ha sido beneficiosa para el tratamiento de personas con nocardiosis. Este informe describe un caso de infección cutánea con Nocardia spp. que afectaba a un gato, con lesiones limitadas a la piel. A entender de los autores, este es el primer informe de HBOT, combinado con amikac... | es |
pair_34107574 | Ultrasound is a non-invasive, real-time, inexpensive, radiation-free and easily repeatable method, usually used for liver imaging. In recent years, new ultrasound examination techniques for liver diseases such as contrast-enhanced ultrasound and elastography have been rapidly developed, which can effectively identify i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 超声检查无创、实时、价廉，无辐射、便于反复进行，是最常用的肝脏影像学检查方法。近年来，超声检查新技术如超声造影、弹性成像发展迅速，可有效鉴别肝内占位性病变性质、评估肝纤维化和门静脉高压程度以及监测肝病治疗效果，在临床肝病及其介入治疗中发挥重要诊断价值。本指南规范了肝病多模态超声技术（灰阶超声、彩色多普勒超声、超声造影、弹性超声）检查的仪器调置、患者准备及医生检查方法；对肝脏弥漫性病变（炎性病变、纤维化、硬化）、多种占位性病变及肝病介入操作的多模态超声技术诊断标准进行了定义和规范，同时推荐了超声监测周期及肝脏疾病超声诊断报告书写规范。. | zh-cn |
pair_34107586 | 42 cases with gastroesophageal varices were prospectively included. The groups were treated with endoscopic band ligation or combined with tissue adhesive. The results showed that the left gastric vein internal diameter, average blood flow velocity and blood flow volume after the treatment of band ligation combined wit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 前瞻性纳入42例胃食管静脉曲张患者资料，分组采用内镜下胶圈套扎或联合组织黏合剂治疗，结果显示套扎联合组织黏合剂治疗后胃左静脉内径、平均流速及血流量的下降趋势均比单纯胶圈套扎治疗明显，差异均有统计学意义（<i>P</i>值均< 0.05）；两组治疗后脾静脉和门静脉的内径、血流量和平均流速，以及肝脾大小、剪切波速度和肝功能分级均无明显变化（<i>P</i>值均> 0.05）；套扎联合组织黏合剂治疗食管静脉曲张、胃底静脉曲张的有效率（66.67%、52.38%）均高于单纯胶圈套扎（42.85%、23.81%）（<i>P</i>值均> 0.05），后者再出血率更高（9.52%和19.05%，<i>P</i> > 0.05）。提示联合治疗更为... | zh-cn |
pair_34107590 | After partial hepatectomy (PH) or liver injury, hepatocytes in a proliferating quiescent state are activated and begin to expand to repair the damaged liver. In recent years, studies have recognized that non-coding RNA (ncRNA) represented by microRNA (miRNA) and long non-coding RNA (lncRNA) can participate in liver reg... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在肝大部分切除或肝损伤后，处于增殖静止状态的肝细胞被激活并扩增以修复受损的肝脏，近年研究发现以微小RNA（miRNA）和长链非编码RNA（lncRNA）为代表的非编码RNA可以通过调控肝细胞的增殖、凋亡、自噬以及肝脏祖细胞的增殖和迁移等来参与肝再生。现就miRNA和lncRNA与肝再生的关系进行综述，以期为肝脏疾病及肝再生领域提供新的治疗策略。. | zh-cn |
pair_34107591 | Chronic liver diseases caused by a variety of causes can lead to the formation of liver fibrosis, and further develop into liver cirrhosis, which is a serious threat to human life and health. As a new research field, lipidomics has been developing vigorously in recent years and has shown great potential in the field of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 多种病因引起的慢性肝脏疾病都可导致肝纤维化形成，并可进一步发展至肝硬化，严重威胁人类生命健康。脂质组学作为新兴研究领域在近年来蓬勃发展，已经在肝纤维化研究领域展现出巨大的潜力。现介绍脂质组学技术，以及探讨脂质在肝纤维化中的致病机制、脂肪毒性生物学标志物和新兴治疗靶点的研究，并对未来肝纤维化领域的脂质组学发展提出展望。. | zh-cn |
pair_34107592 | CircRNA is a new endogenous non-coding RNA(ncRNA ) and a member of the competitive endogenous RNA(ceRNA) family. Some researches have found that circRNA exists widely in organisms and interacts with miRNA, which has certain influence on the occurrence and development of liver diseases. This article reviews the research... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 环状RNA（circRNA）是一种新兴的内源性非编码RNA（ncRNA），同时也是竞争性内源RNA（ceRNA）家族中的成员，有研究发现circRNA广泛存在于生物体内，与微RNA（miRNA）相互作用，对肝脏疾病的发生、发展起重要作用。现就circRNA及其生物学功能、以及circRNA与肝脏疾病关系的研究进展进行综述，以期更好地阐述circRNA在肝脏疾病中的作用，更好地指导临床。. | zh-cn |
pair_34107593 | Cholangiocarcinoma is a kind of malignant tumor that originates from the bile duct epithelium. Due to its insidious nature, there is no effective early diagnosis and treatment method. Therefore, once it is detected, it is at an advanced stage and has a poor prognosis. Bile acid is the main component of bile, which acts... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胆管癌是一种起源于胆管上皮的恶性肿瘤，因发病隐匿，缺乏有效的早期诊断方法，一经发现均属于晚期，预后不良。胆汁酸是胆汁的主要成分，它可通过胆汁酸受体作用于胆管细胞，在胆管癌的发生演变中起着关键作用，而肠道微生物可通过调节胆汁酸代谢参与胆管癌的发生。现主要针对胆汁酸、胆汁酸受体在胆管癌发生和发展中的作用以及肠道微生物在其中的影响进行综述。. | zh-cn |
pair_34108751 | To determine the reasons for the lack of priority given to addressing violence against children, and to identify the challenges that proponents must address to improve prioritization of this issue. We reviewed relevant literature to identify experts to interview. We carried out a thematic analysis of the literature and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 确定对解决暴力侵害儿童问题缺乏优先考虑的原因，并确定支持者为改善这一问题的优先次序必须解决的挑战。. 我们查阅了相关文献评论以确定访谈需要邀请的专家，然后对文献和访谈记录开展了主题分析。经过反复测试，，我们对儿童遭受暴力侵害的特征、支持者对该问题的界定，以及治理问题进行了数据编码，研究支持者应如何组织开展集体行动。. 我们对我们的数据来源进行了分析，揭示了在全球优先处理暴力侵害儿童问题上的许多障碍，包括所考虑的暴力形式、描述普遍程度的数据不足，以及缺乏证据证明所提议解决方案的有效性。支持者对最近提出的如何界定对儿童的暴力存在根本分歧，包括在应列为优先事项的暴力类型和拟议的解决办法（例如预防或补救）方面存在差异。在治理方面，专注于不同... | zh-cn |
pair_34108751 | To determine the reasons for the lack of priority given to addressing violence against children, and to identify the challenges that proponents must address to improve prioritization of this issue. We reviewed relevant literature to identify experts to interview. We carried out a thematic analysis of the literature and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Définir les raisons expliquant pourquoi la violence envers les enfants n'est pas une priorité, et identifier les défis que les acteurs de cette lutte doivent relever pour améliorer sa visibilité. Nous avons effectué une revue documentaire afin de trouver des experts à interroger. Nous avons également réalisé une analys... | fr |
pair_34108751 | To determine the reasons for the lack of priority given to addressing violence against children, and to identify the challenges that proponents must address to improve prioritization of this issue. We reviewed relevant literature to identify experts to interview. We carried out a thematic analysis of the literature and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Determinar las razones por las que no se da prioridad al tratamiento de la violencia contra los niños, e identificar los retos que los defensores deben abordar para mejorar la priorización de esta cuestión. Revisamos la bibliografía pertinente para identificar a los expertos a los que entrevistar. Realizamos un análisi... | es |
pair_34108751 | To determine the reasons for the lack of priority given to addressing violence against children, and to identify the challenges that proponents must address to improve prioritization of this issue. We reviewed relevant literature to identify experts to interview. We carried out a thematic analysis of the literature and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Определить причины недостаточного внимания, уделяемого решению проблем насилия в отношении детей, и задачи, которые необходимо решать инициаторам мер для повышения приоритетности этого вопроса. Авторы изучили соответствующую литературу с целью отбора экспертов для проведения интервью. Был проведен тематический анализ л... | ru |
pair_34108752 | To assess the implementation of a mobile dispensing service to improve opioid users' access to methadone maintenance therapy. In March 2019, we started mobile methadone dispensing in an urban underprivileged locality in Delhi, India. The doctor was available only at the main community drug treatment clinic for clinical... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 评价美沙酮流动服药车的实施情况，以提高吸毒人员美沙酮维持治疗的可及性。. 我们于 2019 年 3 月在印度德里的一个贫困城市地区启动了美沙酮流动服药项目。医生只在主要的社区药物治疗诊所提供临床服务，而护士在改装的救护车上发放美沙酮。我们在确定社区领导（出于敏感性考虑）和确定配药地点及时间方面采纳了患者的意见，并对在提供临床服务期间收集到的项目数据进行了回顾性图表总结。我们比较了报名接受美沙酮治疗的患者数量，以及他们在流动服药车项目实施前和实施后 12 个月内的坚持用药情况。. 在该诊所登记接受治疗的患者从实施前一年内的 167 人增加到实施后一年内的 671 人。报名后 3 个月、6 个月和 9 个月坚持治疗的患者比例明显更高；实... | zh-cn |
pair_34108752 | To assess the implementation of a mobile dispensing service to improve opioid users' access to methadone maintenance therapy. In March 2019, we started mobile methadone dispensing in an urban underprivileged locality in Delhi, India. The doctor was available only at the main community drug treatment clinic for clinical... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Analyser la mise en œuvre d'un service de distribution mobile destiné à améliorer l'accès des consommateurs d'opiacés au traitement de maintien à la méthadone. En mars 2019, nous avons commencé la distribution mobile de méthadone dans une agglomération urbaine défavorisée à Delhi, en Inde. Le médecin restait au centre ... | fr |
pair_34108752 | To assess the implementation of a mobile dispensing service to improve opioid users' access to methadone maintenance therapy. In March 2019, we started mobile methadone dispensing in an urban underprivileged locality in Delhi, India. The doctor was available only at the main community drug treatment clinic for clinical... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Evaluar la implementación de un servicio de distribución móvil para mejorar el acceso de los usuarios de opioides a la terapia de mantenimiento con metadona. En marzo de 2019, iniciamos la distribución móvil de metadona en una localidad urbana desfavorecida de Delhi (India). El médico solo estaba disponible en la clíni... | es |
pair_34108752 | To assess the implementation of a mobile dispensing service to improve opioid users' access to methadone maintenance therapy. In March 2019, we started mobile methadone dispensing in an urban underprivileged locality in Delhi, India. The doctor was available only at the main community drug treatment clinic for clinical... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Оценить эффективность внедрения мобильной службы раздачи для повышения доступности метадоновой поддерживающей терапии для потребителей опиоидов. В марте 2019 года авторы приступили к мобильной раздаче метадона в неблагополучном городском районе Дели (Индия). Врачебная помощь была доступна только в основной наркологичес... | ru |
pair_34108753 | To assess the prevalence and exacerbating factors of violence against women and children in Germany during the coronavirus disease 2019 pandemic. We conducted a representative online survey with partnered women (18-65 years) between 22 April and 8 May 2020, when participants had been under lockdown for a month. We dete... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的 旨在评估德国新型冠状病毒肺炎期间妇女儿童遭受暴力攻击的普遍性和相关刺激因素。方法 在 2020 年 4 月 22 日至 2020 年 5 月 8 日期间，我们面向已居家隔离一个月之久的女性伴侣（18-65 岁）开展了一项具有代表性的线上调查。我们通过直接诱引和一系列实验，确定了前一个月内发生的几种普遍的暴力形式。我们进行了多变量逻辑回归分析，以评估大流行相关风险因素的影响。结果 在 3818 名调查受访者中，118 名（3.09%；95% 置信区间，CI：2.54 至 3.64）报告存在肢体冲突，293 名（7.67％；95% CI：6.83 至 8.52）报告存在精神虐待，在 1474 名有子女的受访者中，97 名（6.58... | zh-cn |
pair_34108753 | To assess the prevalence and exacerbating factors of violence against women and children in Germany during the coronavirus disease 2019 pandemic. We conducted a representative online survey with partnered women (18-65 years) between 22 April and 8 May 2020, when participants had been under lockdown for a month. We dete... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Mesurer la fréquence et les facteurs aggravant la violence envers les femmes et les enfants en Allemagne durant la pandémie de maladie à coronavirus 2019. Nous avons mené une enquête représentative en ligne auprès de femmes vivant en couple (18–65 ans) entre le 22 avril et le 8 mai 2020, au moment où les participantes ... | fr |
pair_34108753 | To assess the prevalence and exacerbating factors of violence against women and children in Germany during the coronavirus disease 2019 pandemic. We conducted a representative online survey with partnered women (18-65 years) between 22 April and 8 May 2020, when participants had been under lockdown for a month. We dete... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Evaluar la prevalencia y los factores agravantes de la violencia contra las mujeres y los niños en Alemania durante la pandemia de la enfermedad del coronavirus 2019. Realizamos una encuesta online representativa con mujeres en pareja (18-65 años) entre el 22 de abril y el 8 de mayo de 2020, cuando las participantes ll... | es |
pair_34108753 | To assess the prevalence and exacerbating factors of violence against women and children in Germany during the coronavirus disease 2019 pandemic. We conducted a representative online survey with partnered women (18-65 years) between 22 April and 8 May 2020, when participants had been under lockdown for a month. We dete... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Оценка распространенности насилия в отношении женщин и детей и усугубляющих его факторов в Германии во время пандемии коронавирусной инфекции 2019 года. Авторы провели репрезентативный интернет-опрос с участием женщин (18–65 лет) в период с 22 апреля по 8 мая 2020 года, когда участники находились в изоляции на протяжен... | ru |
pair_34108754 | To assess the characteristics of cooking-related burn injuries in children reported to the World Health Organization Global Burn Registry. On 1 February 2021, we downloaded data from the Global Burn Registry on demographic and clinical characteristics of patients younger than 19 years. We performed multivariate regress... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 旨在评估向世卫组织全球烧伤注册平台报告的烹饪相关儿童烧伤事件的特征。. 2021 年 2 月 1 日，我们从全球烧伤注册平台上下载了 19 岁以下患者的人口统计学和临床特征相关数据。通过进行多元回归分析，我们确定了风险因素，预测了因烧伤而导致的死亡率和全身表面积感染率。. 在 2957 例烧伤的儿科患者中，974 例的受伤原因与烹饪有关 (32.9%)。烧伤患者中，男孩（532 例；占 54.6％）数量多于女孩数量且 2 岁及以下儿童（489 例；占 50.2％）占比较大。大多数人是因意外接触和液化石油气（分别为 729 例；占 74.8％ 和 293 例；占 30.1％）而导致被烧伤。因烹饪区爆炸（优势比，OR：2.8；95％ 置... | zh-cn |
pair_34108754 | To assess the characteristics of cooking-related burn injuries in children reported to the World Health Organization Global Burn Registry. On 1 February 2021, we downloaded data from the Global Burn Registry on demographic and clinical characteristics of patients younger than 19 years. We performed multivariate regress... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Définir les caractéristiques des brûlures liées à la cuisine chez les enfants, et signalées au Registre des brûlures de l'Organisation mondiale de la Santé. Le 1er février 2021, nous avons téléchargé les données du Registre mondial des brûlures concernant les caractéristiques démographiques et cliniques des patients âg... | fr |
pair_34108754 | To assess the characteristics of cooking-related burn injuries in children reported to the World Health Organization Global Burn Registry. On 1 February 2021, we downloaded data from the Global Burn Registry on demographic and clinical characteristics of patients younger than 19 years. We performed multivariate regress... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Evaluar las características de las lesiones por quemaduras relacionadas con la cocina en niños notificadas al Registro Mundial de Quemaduras de la Organización Mundial de la Salud. El 1 de febrero de 2021, descargamos los datos del Registro Mundial de Quemaduras sobre las características demográficas y clínicas de los ... | es |
pair_34108754 | To assess the characteristics of cooking-related burn injuries in children reported to the World Health Organization Global Burn Registry. On 1 February 2021, we downloaded data from the Global Burn Registry on demographic and clinical characteristics of patients younger than 19 years. We performed multivariate regress... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Оценить характеристики ожоговых травм у детей, связанных с приготовлением пищи, зарегистрированные в Глобальном реестре ожогов Всемирной организации здравоохранения. 1 февраля 2021 года авторы загрузили данные о демографических и клинических характеристиках пациентов младше 19 лет из Глобального реестра ожогов. Для выя... | ru |
pair_34108755 | To determine the acceptability of keeping a self-written health diary among members of low-income communities, with the aim of generating needed health data. We identified three different types of impoverished communities (tribal, inner-city slum and rural) in north India, and conducted a baseline survey to establish t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 旨在确定低收入社区成员对于由自己坚持填写健康日记这种方式的接受度，并最终生成所需的健康数据。. 我们发现印度北部存在三种不同类型的贫困社区（部落、内城区贫民窟和农村），于是展开基线调查，以确定各类社区家庭成员的社会人口统计学特征，其中包括部落的 595 个家庭、贫民窟的 446 个家庭以及农村的 51 个家庭。我们设计了一种每月仅需填写一页且每页均带复写页的健康日记，然后将此类日记分发给愿意参加的家庭。在连续一年内，健康志愿者每月都会上门协助他们完成日记并收集复写页。我们将健康日记中报告的患病频率与基线调查数据进行了比较。. 共有 4881 名日记用户（部落：2205；贫民窟：2185，农村：491）参与我们这个项目。在接受度方面，... | zh-cn |
pair_34108755 | To determine the acceptability of keeping a self-written health diary among members of low-income communities, with the aim of generating needed health data. We identified three different types of impoverished communities (tribal, inner-city slum and rural) in north India, and conducted a baseline survey to establish t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Déterminer si les membres des communautés à faible revenu sont prêts à accepter de tenir eux-mêmes un carnet de santé afin de générer les données requises en la matière. Nous avons identifié trois différents types de communautés défavorisées (communautés tribales, bidonvilles en milieu urbain et communautés rurales) en... | fr |
pair_34108755 | To determine the acceptability of keeping a self-written health diary among members of low-income communities, with the aim of generating needed health data. We identified three different types of impoverished communities (tribal, inner-city slum and rural) in north India, and conducted a baseline survey to establish t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Determinar la aceptabilidad de llevar un diario de salud escrito por uno mismo entre los miembros de las comunidades de bajos ingresos, con el objetivo de generar los datos de salud necesarios. Identificamos tres tipos diferentes de comunidades empobrecidas (tribales, barrios marginales del centro de la ciudad y rurale... | es |
pair_34108755 | To determine the acceptability of keeping a self-written health diary among members of low-income communities, with the aim of generating needed health data. We identified three different types of impoverished communities (tribal, inner-city slum and rural) in north India, and conducted a baseline survey to establish t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Определить приемлемость ведения рукописного дневника здоровья среди членов общин с низким уровнем дохода с целью получения необходимых данных о состоянии здоровья. Авторы выделили три различных типа бедных общин (племенные общины, городские трущобы и сельские районы) на севере Индии и провели базовое исследование с цел... | ru |
pair_34108756 | To review misinformation related to coronavirus disease 2019 (COVID-19) on social media during the first phase of the pandemic and to discuss ways of countering misinformation. We searched PubMed®, Scopus, Embase®, PsycInfo and Google Scholar databases on 5 May 2020 and 1 June 2020 for publications related to COVID-19 ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 综述第一波新型冠状病毒肺炎疫情期间，社交媒体上相关的虚假信息，并探讨应对虚假信息的方式。. 我们于 2020 年 5 月 5 日和 2020 年 6 月 1 日通过 PubMed®、Scopus、 Embase®、PsycInfo 及谷歌学术数据库，搜索了有关新型冠状病毒肺炎的发布信息以及涉及错误信息的社交媒体，其均为主要的实证研究。我们依据系统综述首选的报告项目，以及通过元分析和衡量工具，评估系统综述指导方针。利用推荐分级的评估、制定与评价方法，对纳入研究的证据质量和偏倚风险进行分类。该综述已在国际前瞻性系统综述注册网站注册 (PROSPERO; CRD42020182154)。. 我们确定了 22 项研究纳入定性综合。社交媒体上... | zh-cn |
pair_34108756 | To review misinformation related to coronavirus disease 2019 (COVID-19) on social media during the first phase of the pandemic and to discuss ways of countering misinformation. We searched PubMed®, Scopus, Embase®, PsycInfo and Google Scholar databases on 5 May 2020 and 1 June 2020 for publications related to COVID-19 ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Analyser la désinformation autour de la maladie à coronavirus 2019 (COVID-19) sur les réseaux sociaux durant la première phase de la pandémie, et discuter des moyens de lutter contre cette désinformation. Nous avons effectué une recherche dans les bases de données de PubMed®, Scopus, Embase®, PsycInfo et Google Scholar... | fr |
pair_34108756 | To review misinformation related to coronavirus disease 2019 (COVID-19) on social media during the first phase of the pandemic and to discuss ways of countering misinformation. We searched PubMed®, Scopus, Embase®, PsycInfo and Google Scholar databases on 5 May 2020 and 1 June 2020 for publications related to COVID-19 ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Revisar la desinformación relacionada con la enfermedad por coronavirus 2019 (COVID-19) en las redes sociales durante la primera fase de la pandemia y debatir las formas de contrarrestar la desinformación. Se realizaron búsquedas en las bases de datos PubMed®, Scopus, Embase®, PsycInfo y Google Scholar el 5 de mayo de ... | es |
pair_34108756 | To review misinformation related to coronavirus disease 2019 (COVID-19) on social media during the first phase of the pandemic and to discuss ways of countering misinformation. We searched PubMed®, Scopus, Embase®, PsycInfo and Google Scholar databases on 5 May 2020 and 1 June 2020 for publications related to COVID-19 ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Составить обзор ложной информации, связанной с коронавирусным заболеванием 2019 г. (COVID-19), в социальных сетях во время первой фазы пандемии и обсудить пути противодействия распространению дезинформации. Авторы выполнили поиск публикаций, посвященных COVID-19 и социальным сетям, которые рассматривали ложную информац... | ru |
pair_34108757 | To identify and describe summarized evidence on factors associated with diet and physical activity in low- and middle-income countries in Africa and the Caribbean by performing a scoping review of reviews. We searched the Medline®, LILACS, Scopus, Global Health and Web of Science databases for reviews of factors associ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 旨在通过对综述文献进行概况性评价，确定和说明非洲和加勒比地区中低收入国家饮食和身体活动相关因素的汇总证据。. 我们搜索了 Medline®、LILACS、Scopus、全球健康和科学网数据库，以查看 1998 年至 2019 年期间发布的饮食或身体活动相关因素综述文献。在这些综述文献中，至少有 25％ 的研究项目来自非洲或加勒比地区。使用 Dahlgren 和 Whitehead 的健康社会模型对因素进行了分类。但并未进行质量鉴定。. 我们确定了 25 份综述文献：其中 13 份与饮食有关，4 份关于身体活动，8 份与两者均有关。十八篇文章采用了定量系统评价方法。在 12 份综述文献中，25-50% 的研究项目来自非洲或加勒比地区。... | zh-cn |
pair_34108757 | To identify and describe summarized evidence on factors associated with diet and physical activity in low- and middle-income countries in Africa and the Caribbean by performing a scoping review of reviews. We searched the Medline®, LILACS, Scopus, Global Health and Web of Science databases for reviews of factors associ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Identifier et décrire les synthèses de données probantes consacrées aux facteurs liés au régime alimentaire et à l'activité physique dans les pays à faible et moyen revenu en Afrique et dans les Caraïbes, en examinant la portée des revues. Nous avons examiné les bases de données Medline®, LILACS, Scopus, Global Health ... | fr |
pair_34108757 | To identify and describe summarized evidence on factors associated with diet and physical activity in low- and middle-income countries in Africa and the Caribbean by performing a scoping review of reviews. We searched the Medline®, LILACS, Scopus, Global Health and Web of Science databases for reviews of factors associ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Identificar y describir las pruebas resumidas sobre los factores asociados a la dieta y la actividad física en los países de ingresos bajos y medios de África y el Caribe mediante la realización de una revisión del alcance de las revisiones. Realizamos búsquedas en las bases de datos Medline®, LILACS, Scopus, Global He... | es |
pair_34108757 | To identify and describe summarized evidence on factors associated with diet and physical activity in low- and middle-income countries in Africa and the Caribbean by performing a scoping review of reviews. We searched the Medline®, LILACS, Scopus, Global Health and Web of Science databases for reviews of factors associ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Выявить и описать обобщенные данные о факторах, связанных с питанием и физической активностью, в странах Африки и Карибского бассейна с низким и средним уровнем доходов путем составления обзора проведенных исследований. Авторы выполнили поиск информации в базах данных Medline®, LILACS, Scopus, Global Health и Web of Sc... | ru |
pair_34114656 | Over the past decades, mindfulness-based interventions have been shown to improve individual health and well-being in clinical and nonclinical settings. More recently, secular contemplative trainings were adapted to the couple context as research showed satisfying couple relationships to be one of the strongest predict... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在过去的几十年里，基于正念的干预措施已被证明可以在临床和非临床环境中改善个人健康和幸福。最近，非临床的冥想训练被用来为伴侣关系服务，因为研究表明，伴侣关系的幸福满意度是身体和心理健康的最有力预测因素之一。因此，基于正念的干预措施似乎是临床和非临床环境中伴侣咨询和伴侣治疗的一种有前途的治疗方法。因此，我们进行了一次系统性的回顾，对新近的以正念为基础的伴侣干预和其他二元关系人群的干预措施方面的研究文献进行了概述。总体而言，有16项研究符合纳入标准。关于个人结果的异质性定量文献综述来看，伴侣间的正念干预似乎可以增加正念、自我同情、幸福感和生活质量。此外，我们发现初步证据表明，冥想对缓解心理病理症状和心理生物压力的措施有好处。关系质量的测量... | zh-cn |
pair_34114656 | Over the past decades, mindfulness-based interventions have been shown to improve individual health and well-being in clinical and nonclinical settings. More recently, secular contemplative trainings were adapted to the couple context as research showed satisfying couple relationships to be one of the strongest predict... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Durante las últimas décadas, se ha demostrado que las intervenciones basadas en la conciencia plena mejoran la salud y el bienestar en entornos clínicos y no clínicos. Recientemente, se adaptaron capacitaciones contemplativas seculares al contexto de la pareja, ya que las investigaciones demostraron que las relaciones ... | es |
pair_34117381 | Glaucoma, its early diagnosis, and monitoring of interventions remain an ongoing challenge. We here review developments in functional assessment and its relation to morphology, evaluating recent insights in electrophysiology in glaucoma and highlighting how glaucoma research and diagnostics benefit from combined approa... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 摘要: 青光眼的早期诊断和干预的监测仍然是一个持续性的挑战。在此, 我们回顾了功能评估及其与形态学关系的进展, 评价了青光眼电生理学的最新观点和见解, 并强调了联合使用OCT以及无创电生理在青光眼的研究方面获益。在简要综述了OCT和无创电生理学在青光眼中的应用后, 我们评估了OCT和电生理学在我们理解青光眼方面的共同点和互补性。除此之外, 我们将各种技术的动态范围 (天花板效应) 作为一个特定的主题进行了讨论。. | zh-cn |
pair_34117382 | Clinical electrophysiological assessment of optic nerve and retinal ganglion cell function can be performed using the Pattern Electroretinogram (PERG), Visual Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other more specialised techniques. In this review, we describe these electrophysiologica... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 摘要: 使用图形视网膜电流图 (Pattern Electroretinogram, PERG)、视觉诱发电位 (Visual Evoked Potential, VEP) 和感光阴性反应 (Photopic Negative Response, PhNR) 以及其他更专业的技术可以进行视神经和视网膜神经节细胞功能的临床电生理评估。本文中, 我们描述了这些电生理技术及其在除青光眼以外的影响视神经和视网膜神经节细胞疾病中的应用。讨论的疾病组包括遗传性、应力性、毒性/营养性、外伤性、血管性、炎性和颅内原因导致的视神经或视网膜神经节细胞功能障碍。本文讨论了客观的、电生理测量视网膜神经节细胞和视神经的优势, 以及它们在疾病的临床诊断、评估预... | zh-cn |
pair_34117388 | Varied options are available for the implantation of secondary intraocular lens implants in the absence of zonular or capsular support. Loss of the capsule can occur in the context of complicated cataract surgery, trauma or inherited conditions such as Marfan syndrome or pseudoexfoliation. Approaches to overcome this i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 摘要: 经巩膜缝线固定的眼内人工晶状体植入术——手术技术的演变与未来发展摘要在缺乏晶状体悬韧带或囊膜支撑的情况下, 二期人工晶状体植入有多种选择。在复杂性白内障手术、外伤或遗传性疾病 (如马凡氏综合征或假性脱落) 的白内障手术中, 可能会出现晶状体囊膜缺失的情况。而光学治疗措施 (佩戴框架眼镜或隐形眼镜) 以及手术方法 (结合使用前房、虹膜固定或巩膜固定的人工晶状体) 可以解决问题。自20世纪80年代首次发表关于巩膜内固定术的文章以来, 植入经巩膜缝线固定人工晶体的外科技术经历了各种各样的改进。然而, 尽管外科手术技术有了进步, 但由于研究为回顾性、样本量小和最重要的随访时间短, 研究结果不尽人意。本综述旨在深度探讨经巩膜缝线固定人... | zh-cn |
pair_34117390 | Ophthalmic surgery requires a highly dexterous and precise surgical approach to work within the small confines of the eye, and the use of robotics offers numerous potential advantages to current surgical techniques. However, there is a lag in the development of a comprehensive training and credentialing system for robo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 摘要: 眼科手术需要高度灵敏和精确的方法在眼部小范围工作, 而机器人的使用为当前的手术技术提供了许多潜在优势。然而, 机器人眼科手术的全面培训和认证体系的发展还很滞后, 机器人技能熟练程度的认证在很大程度上依赖于行业的领先地位。我们对已建立的机器人培训项目的课程内容进行了文献回顾, 并从各个机构获取了临床指南, 概述了眼科手术机器人外科医生的培训和认证的关键组成部分。基于我们的文献回顾和作者与其他机器人眼科专家之间的非正式讨论, 我们建议机器人眼科受训人员的整体培训框架以逐步的、基于能力的方式进行, 从教学式学习, 到模拟练习, 到最后的手术实践。非技术技能, 如设备故障排除和跨专业团队合作, 也应正式教授和评估。此外, 我们还开发... | zh-cn |
pair_34117702 | Traditional Chinese medicine (TCM) has a long history of serving the Chinese people's health since its birth, including playing an important role in treating and preventing COVID-19 in 2020. The fact that TCM has been used in China for thousands of years shows the value and reason why it must exist. Although TCM has be... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 中医药历史悠久, 自诞生以来一直为中国人民的健康服务, 包括此次在抗击新冠肺炎疫情中也发挥着重要作用。中医在中国已经使用了数千年, 这一事实说明了中医存在的价值。尽管中医曾经或仍在受质疑, 但就疗效而言, 其重要性毋庸置疑。本文通过与西医解剖学知识的比较, 论述了中医对人体的认识, 并从人体观和理论创新两方面论述了中医的发展和进步, 旨在让国外学者从此角度更好地认识中医。. | zh-cn |
pair_29424131 | L-arginine (L-Arg) is an alkaline amino acid that possesses various function groups and acts as an important precursor for useful chemical synthesis. L-Arg derivatives are widely applied in pharmaceutical, food and cosmetic industries. Environment friendly and cost-effective production of L-Arg derivatives by enzymatic... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | None | zh-cn |
pair_29424132 | Lignocellulose is the most abundant renewable biomass resource. Enzymatic breakdown of lignocellulose into oligosaccharides or monosaccharides is the key to exploit lignocellulosic biomass. However, traditional glycoside hydrolases are insufficient to degrade lignocellulose. The emergence of lytic polysaccharide monoox... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 木质纤维素是地球上储藏量最为丰富的可再生生物资源。将木质纤维素酶解成寡糖或单糖是生物质利用的关键。然而，传统的糖苷水解酶很难对其进行有效降解。溶解性多糖单加氧酶是一种全新的生物质降解酶，丰富了生物质降解的模式。它以氧化方式作用于糖链，产生更多的还原端以便糖苷水解酶能进一步进行催化。本文综述了LPMO 的发现历史、分类、作用机制与活性测定方法，并讨论了LPMO 在饲料添加剂、功能性食品与生物能源等领域的应用前景。. | zh-cn |
pair_29424133 | Enzyme is an efficient and green biocatalyst, and widely used in many areas. Immobilized enzyme is superior to its free form in a variety of properties. Enzyme immobilization studies started in the 1970s in China. Till now, immobilized enzymes are widely applied in the fields of food, medical, energy, environmental man... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 酶是一种高效、绿色、应用广泛的生物催化剂，因其固定化形态在多种性质上均优于游离态，酶固定化技术应运而生并不断发展。我国固定化技术研究始于20 世纪70 年代，目前固定化酶在食品、医疗、能源、环境治理等领域得到了广泛的应用，但现有固定化技术仍存在适用范围小、成本较高等缺陷。因此，在较为成熟的传统固定化技术基础上，研究者们对新型固定化技术的研究与创新进行了大量尝试，形成了一批以固定化载体和固定化方式为核心的新型固定化技术。文中作者结合团队十余年对固定化技术的研究和理解，归纳介绍了新型酶固定化技术的发展方向和应用趋势，并阐述了对固定化技术未来发展的理解和建议。. | zh-cn |
pair_29424135 | Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is a devastating viral disease in swine, leading to significant economic losses to the pig husbandry. C-strain is one of the best modified live vaccines against CSF. The vaccine is highly safe and efficacious and can provide rapid and complete p... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 猪瘟 (CSF) 是由猪瘟病毒 (CSFV) 引起的一种毁灭性传染病，给养猪业造成重大经济损失。猪瘟兔化弱毒疫苗 (C 株) 是一株非常安全、有效的优秀弱毒疫苗，对各年龄和品种的猪都极其安全，同时对不同基因亚型的CSFV均能提供有效的免疫保护。在现地，CSFV 和猪圆环病毒2 型 (PCV2) 混合感染的现象时常发生，有必要研制针对这两种病毒混合感染的二价疫苗。本研究首次构建了表达PCV2 Cap 蛋白的重组C 株，并评价了其在体内外的特性。结果表明，该重组病毒与C 株具有相近的体外增殖特征，能够稳定表达Cap 蛋白，在家兔体内具有与C 株相似的生物学表型，在免疫家兔后10 d，抗CSFV E2 抗体全部转阳，然而抗Cap 抗体未能... | zh-cn |
pair_29424137 | Cyclic lipopeptide has extensive application prospect in the field of medicine due to its unique chemical structure and biological activity. This study aims to obtain high purity of cyclic lipopeptide monomer from Bacillus amyloliquefaciems strain Q-426, and illuminate preliminary antitumor mechanism of C-15 Bacillomyc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 环脂肽化合物因其独特的结构特点和生物活性在医药领域具有广泛的应用前景。本研究旨在从解淀粉芽孢杆菌Q-426 发酵液中分离纯化获得高纯度的环脂肽单体，并对分离得到的环脂肽C-15 Bacillomycin D 和C-16 Bacillomycin D 的抗肿瘤活性及机制进行初步研究。首先，联合使用酸沉淀和双树脂层析去除大量杂质，然后通过制备型HPLC 分离得到纯度较高的两种环脂肽，经ESI-MS/MS 对其进行结构鉴定，分别确定为C-15 Bacillomycin D 与C-16 Bacillomycin D。其次，将两种环脂肽单体及其1：1 混合液 (摩尔比) 按不同浓度梯度作用于人癌细胞 (Hela、MG、Hep-G2、HT-29... | zh-cn |
pair_29424136 | Glycolic acid is an important industrial compound. To improve glycolic acid yield, we knocked out ldhA (lactate dehydrogenase) in Escherichia coli MG1655 (DE3) to get the strain Mgly1. Then, we regulated expression levels of isocitrate lyase (aceA), glyoxylic acid reductase (ycdW) and isocitrate dehydrogenase kinase/ph... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 乙醇酸 (Glycolate) 是一种在工业上有多种用途的重要化合物。本研究首先在大肠杆菌MG1655(DE3)中敲除了ldhA (乳酸脱氢酶)，获得菌株Mgly1，作为出发菌株。然后通过调节乙醇酸合成途径的关键酶——异柠檬酸裂解酶 (aceA)、乙醛酸还原酶 (ycdW)、异柠檬酸脱氢酶激酶/磷酸化酶 (aceK) 的表达水平，得到乙醇酸产率为0.24 g/g 葡萄糖 (占理论产率的28.2%)。过量表达柠檬酸合成酶 (gltA)，乙醇酸产率提高到0.326 g/g 葡萄糖(占理论产率的38.3%)。然后在Mgly1 中敲除了glcB 和aceB (苹果酸合成酶)，减少了乙醇酸合成的前体乙醛酸的消耗。最终获得的工程菌株Mgly33... | zh-cn |
pair_29424138 | In order to study the role of cofactor engineering in enhancing the production of S-adenosylmethionine (SAM), we altered the form and concentration of cofactor in Saccharomyces cerevisiae through gene recombination. Effects of cofactor on product synthesis, carbon and energy metabolism were analyzed aiming to provide a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 通过代谢工程策略改造酿酒酵母胞内辅因子的形式和浓度，分析辅因子NADPH 对于产物S-腺苷蛋氨酸(SAM) 合成的作用并总结能量代谢和其他物质代谢的规律，为高产SAM 菌株的代谢工程改造提供理论基础。由于酿酒酵母中的NADPH 在线粒体和细胞质中的代谢相对独立，因此以酿酒酵母 BY4741 单倍体模式菌株为研究对象，研究了不同亚细胞结构内NADPH 对于产物合成的影响。通过激光共聚焦显微镜证实了NADH 激酶在酿酒酵母线粒体和细胞质中的表达。实验结果表明NADPH 的提高有利于酿酒酵母胞内SAM 的合成。发酵24 h，菌株NBYSM-1 胞内SAM 浓度较对照菌提高3.28 倍，菌株NBYSM-2 胞内SAM 浓度提高1.79 倍。... | zh-cn |
pair_29424139 | We used in vitro molecular evolution technology by error-prone PCR and high-throughput screening to improve thermostability of Bacillus flexus CCTCC 2015368 β-amylase. Mutant D476N with significant thermostability increase was selected by LB agar starch plate colorimetric assay and 96-well plate enzyme activity assay. ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 运用体外分子进化技术易错PCR 方法，高通量筛选热稳定性提高的弯曲芽孢杆菌Bacillus flexus CCTCC 2015368 β-淀粉酶突变体。利用LB 琼脂淀粉板显色、96-孔板DNS 法测酶活和酶标仪检测等，最终筛选到了一株热稳定性显著提高的突变体D476N。野生型和突变体D476N 分别纯化后，酶学性质测定表明：突变体D476N的最适pH 为6.5，与野生型相比降低了0.5。突变体D476N 和野生型的最适温度均为55 ℃，突变体D476N 在55 ℃下的半衰期为35 min，比野生型提高了95%。突变体D476N 的T₅₀ 值比野生型提高4 ℃。突变体D476N 的Km 值为97.98 μmol/L，是野生型 (85... | zh-cn |
pair_29424140 | Glutamine synthetase is a key enzyme in plant nitrogen assimilation. To study the structure of wheat glutamine synthetase isoenzymes, GS1, GSr, GSe, GS2 and GS2p of wheat were cloned into pET-21a, and the expression condition was optimized. Although wheat glutamine synthetase isoenzymes had 70%-80% amino acid sequence ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 谷氨酰胺合成酶 (GS) 是植物氮同化的关键酶，为了研究小麦GS 同工酶的结构及其表达特点，我们构建了小麦GS1、GSr、GSe、GS2 和GS2 前体GS2p 的原核表达载体，并对表达条件进行了优化。结果表明，尽管小麦GS 同工酶氨基酸序列同源性达70%–80%，蛋白质表达却各具特点。30 ℃诱导3 h 后，GSr、GSe 及GS2表达量达最大，诱导7 h 后GS1 表达量达最大，GS2p 不表达，表达量依次为GS1 (22%) >GSr (15%) >GS2(12%)>GSe (5%)；且GSe 可溶性表达，GS1 主要为可溶性表达，而GSr 和GS2 为包涵体。30 ℃诱导3 h，GS 同工酶相对转录量为GSr (7.59) ... | zh-cn |
pair_29424141 | Tea is one of the most popular drinks in the world, but counterfeit or adulterated tea can be found now and then on the tea market. The traditional methods dependent on sensory, physical and chemical tests cannot identify the composition of adulterated plant species accurately. We developed therefore a method for ident... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 茶叶是世界上最受人们欢迎的饮品之一，但茶叶中掺杂其他植物成分的现象时有发生。依靠传统的感官和理化检验方法难以准确判断茶叶中掺杂的植物种类。报道一种基于植物核酮糖-1,5-二磷酸羧化酶/加氧酶大亚基 (rbcL) 基因序列进行茶叶掺杂定性检测的方法，包括rbcL 基因片段的扩增、测序和序列分析等步骤。利用所 建立的方法对7 份茶叶样品进行分析，发现岳阳黄茶 (黄茶) 和信阳毛尖 (绿茶) 未掺杂其他植物成分，而正山小种 (红茶)、铁观音 (乌龙茶)、太姥银针(白茶)、六堡茶和普洱茶 (黑茶) 均一定程度上混杂有其他植物成分。所建立的检测方法对样品的需求量小，操作简便，检测结果可靠性高，能定性检测各类茶叶中是否掺杂及掺杂了何种植物成分。... | zh-cn |
pair_29424142 | In heterologous protein productions by Pichia pastoris, methanol induction is generally initiated when cell density reaches very high level. However, this traditional strategy suffers with the problems of difficulty in DO control, toxic by-metabolites accumulation and low targeted protein titer. Therefore, initiating m... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 重组毕赤酵母生产表达外源蛋白的过程中，一般在细胞达到高密度后开始启动甲醇诱导。也有报道指出，在较低细胞浓度下，启动甲醇诱导可以有效地控制整个发酵过程的溶解氧浓度，缓解毒副产物的积累，促进目标蛋白的表达。但是，该操作策略下，甲醇/能量调控机制不明，相关研究报道很少。文中以生产表达monellin (甜味蛋白) 的重组毕赤酵母为模式菌株，通过在线分析计量甲醇消耗速率、CO₂ 释放速率和O₂ 摄取速率，探讨了不同细胞浓度下启动甲醇诱导和外源蛋白表达体系的甲醇/能量代谢模式。结果表明，在较低细胞浓度 (50 g DCW/L)启动诱导并将温度控制在30 ℃，走向合成monellin 前体物质途径的碳流最大 (65%)，且能与用于ATP 再生的... | zh-cn |
pair_29424143 | Primary hepatocytes are widely used in drug metabolism and toxicity assessment. As the culture of primary hepatocytes in vitro is a process of dedifferentiation, hepatocytes lose normal metabolic detoxification function gradually. The mechanism of hepatocyte dedifferentiation has been not clear so far. TFs play an impo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 原代肝实质细胞被广泛应用到药物代谢和毒性评估中，但其体外培养呈现去分化状态，表现为逐渐失去正常形态和代谢解毒功能，到目前为止对去分化的分子机制并不清楚。在肝实质细胞体外去分化过程中转录因子(Transcription factor，TF) 起重要作用，而且非实质细胞可以在体外维持肝实质细胞功能。然而目前的技术手段不能有效地鉴定和定量分析大量TFs。本文建立了单层肝实质细胞单独培养以及肝实质细胞与非实质细胞共培养系统，细胞培养到24、48、72 h。利用TF 富集技术 (Transcription factor response elements on tip，TOT) 和质谱技术研究在肝实质细胞体外培养过程中TFs 变化。本研究3 ... | zh-cn |
pair_29429190 | Tinnitus is a subjective symptom of phantom sound in the ear or brain without sound or electrical stimulation in the environment. The mechanism of tinnitus is complicated and mostly unclear. Recent studies suggested that the abnormal peripheral auditory input lead to neuroplasticity changes in central nervous system fo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 耳鸣是指在周围环境中无相应声刺激或电刺激存在的情况下，患者自觉耳内或颅内有声音的一种主观症状。耳鸣病因复杂机制大多不清。随着近年研究认为外周听觉传入的异常导致中枢可塑性改变而产生耳鸣，对耳鸣中枢机制的研究逐渐成为热点。功能性磁共振成像技术(fMRI)的快速发展，使其应用于耳鸣中枢机制的研究也不断深入、完善，在获得新发现的同时，也显示出在技术和认知上的不足。本文通过总结近年来fMRI用于耳鸣机制研究的成果，探讨存在的问题及其应用前景。. | zh-cn |
pair_29429232 | To evaluate the clinical results of reconstruction orbital defect with craniomaxillofacial implant. Three patients with orbital defect were treated with ten implants. The magnetic abutments were attached six months after one stage operation and the prostheses were fabricated. Within 11 to 47 months of follow up, all im... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 评价颅颌面种植体修复眶部缺损的临床意义。3例眶内容物剜除术后患者局部麻醉下于眶周缘植入骨内种植体。Ⅰ期术后6个月以磁性基台接出，在基台上方制作赝复体，共植入10枚种植体，随访11~47个月，种植体骨结合良好，未出现松动和脱落；赝复体固位良好，效果满意。以颅颌面骨内种植体为支持的眶部缺损修复术是一种疗效满意的整复方式，有较好的临床应用前景。. | zh-cn |
pair_29429233 | This article introduces the combined application of vacuum sealing drainage (VSD) and chymotrypsin in the treatment of post-operative mandibular osteomyelitis. The lesion was washed by chymotrypsin (4000U) and saline (500 ml). VSD is effective in the treatment of traumatic mandibular osteomyelitis. This study investiga... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 下颌骨创伤后骨髓炎的治疗以手术和药物联合治疗为主。本文介绍采用封闭负压引流技术（vacuum sealing drainage，VSD）为主的病灶清理术，术后同时行4 000 U糜蛋白酶+500 ml生理盐水持续冲洗的治疗方法。初步探讨VSD联合糜蛋白酶在下颌骨创伤后骨髓炎病例中的应用效果，证实其对保证引流、控制感染、保留内固定有良好作用并可为骨折愈合创造良好环境。以期为下颌骨创伤后骨髓炎的有效治疗提供更简便有效的新方法。. | zh-cn |
pair_29429236 | Several systematic reviews and many clinical articles have shown that maxillary sinus floor elevation through lateral window approach (LSFE) is a predictable and reliable procedure, which has been routinely performed for more than 30 years. The complication rate is low, but some cases may require additional surgery, an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 经外侧壁入路的上颌窦底提升植骨术应用于临床已30余年，证实为疗效可靠的上颌后牙区骨增量技术。虽然该术式的并发症发生率较低，但处理不当仍有可能植骨或种植失败。术中并发症的发生并非一定放弃骨手术，恰当处理后仍可获得良好的骨增量效果。对于术后并发症，尤其是术后感染，早诊断、早干预并进行妥善处理，种植体的近期存留率仍较高。本文就经外侧壁入路的上颌窦外提升术的主要并发症的发生率、预防及处理进行讨论。. | zh-cn |
pair_29429237 | The p75 neurotrophic factor receptor is a low affinity receptor for neurotrophic factors and plays an important role in nerve growth, development and function integrity. It is closely related to dental development, oral and maxillofacial tumor, nerve repair and tissue engineering. It shows good prospect for application... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | p75神经营养因子受体属低亲和力神经营养因子受体，在神经生长、发育和维持功能完整性等方面发挥着重要作用，其与牙齿发育、口腔颌面部肿瘤、神经创伤修复、组织工程等密切相关，显示了良好的应用前景。本文就p75神经营养因子受体在口腔医学中的研究进展作一综述。. | zh-cn |
pair_29429238 | Tooth preparation is a basic operation in prosthodontics treatment and the quality of preparation influences the effect of treatment directly. How to achieve a precise and quantitative tooth preparation is always one of the main aims of dental prosthodontics. The known types of tooth preparation guide technique can be ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 牙体预备是口腔修复治疗的基本操作，预备体的质量直接影响修复治疗的效果。如何实现精确定量的牙体预备，一直是口腔修复的主要研究目标。目前，牙体预备定量引导技术主要分为视觉引导、被动约束引导和主动约束引导（自动化牙体预备）3大类，分别以硅橡胶寄存记录法、牙体预备导板和计算机数控切削系统为代表，引导精度逐级增加。近年，学者们也开始探索将机器人系统、数控超短脉冲激光等先进制造技术应用于自动化牙体预备领域。本文归纳总结各类牙体预备定量引导技术的研究现状，并探讨其应用效果及其局限性，以期为相关研究与相关方法的临床选择应用提供参考。. | zh-cn |
pair_29429239 | Cobalt-chromium alloys have been applied to dental porcelain fused to metal (PFM) restorations over the past decades owing to their excellent corrosion resistance, good biocompatibility and low price. The production of CoCr metal-ceramic restorations has always been based on traditional lost-wax casting techniques. How... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 钴铬合金因其优良的耐腐蚀性、生物安全性以及价格低廉等优势而长期用于口腔金属烤瓷基底冠桥的制作。钴铬合金烤瓷修复体的制作一直以传统失蜡铸造技术为主；近年，选区激光熔化（selective laser melting，SLM）技术因其个性化、精准化以及高效等优势而越来越受到义齿制作中心和临床医师的重视与青睐。本文重点就SLM钴铬合金烤瓷基底冠的制作流程、组织结构、力学性能、金-瓷结合强度、基底冠适合性以及耐腐蚀性和生物安全性的最新研究进展进行综述。. | zh-cn |
pair_29429278 | The human gastro-intestinal tract is not only the habitat of gut microbiota, but also the main place that the body gets available nutrients. Therefore, the gut microbiota of human can be inseparable associated with the human nutrition. The common technologies used among gut microbiota research included metageonomic, me... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肠道是肠道菌群的聚集地，更是机体获取营养的最主要场所。因此，肠道菌群与营养及营养相关疾病之间必定存在着密不可分的关系。肠道菌群常用的研究方法包括宏基因组学、宏转录组学、宏蛋白质组学和代谢组学。基于各种组学技术的肠道菌群研究证实膳食是影响肠道菌群组成和表达的主要因素；肠道菌群的比例、数量、稳定状态及其代谢产物的变化与肥胖、糖尿病、心血管疾病等多种营养相关疾病密切相关。通过膳食干预改变肠道微生物的种类和活性表达，能够实现预防和治疗肥胖、糖尿病、冠心病等营养相关疾病的目的。尽管，上述单一组学方法能研究肠道菌群的某一方面的问题，但是为了达到上述目的，需要多组学联合进一步了解肠道菌群与人类营养和健康之间的关系。. | zh-cn |
pair_29429279 | Biomonitoring can be applied to assess internal exposure and environmental exposure by exposure markers with providing internal exposure to biological characterization and individual exposure information, which is a key tool to evaluate the risk exposure to disease by biological alternation information. With the develo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 生物监测通过观察体内生物学信息改变，提供内暴露的生物表征和个体暴露信息，应用暴露标志物来评价内暴露和环境外暴露，是评价暴露-疾病风险的关键工具。随着高通量、广谱、高效的甄别检测技术的发展，生物监测可以分为传统生物监测(有目标的监测)和非目标性的监测分析(暴露组)。暴露组生物监测方法旨在识别对健康和疾病有影响的所有潜在暴露指征，但其生物样品的可及性和质量，以及对新物质特别是非持久性化学物质的识别与监测，乃至如何综合运用统计学处理暴露组复杂的数据集仍面临巨大挑战。结合新兴技术、无目标性的生物监测方法与传统的生物监测技术，结合生物信息学，发展低丰度化学物质的检测方法，提高内源性分子与外源性分子的区分能力，实现内暴露广泛的识别及健康结局的表... | zh-cn |
pair_29429280 | Electronics industry is a typical labor-intensive industry in China. There are a lot of female workers and various occupational hazard factors in the workplace. This article reviewed the characteristics of employment of women in electronics industry, occupational hazards of exposure, protective measures, occupational d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 电子行业是我国典型的劳动密集型行业，女工人数众多，工作场所中职业危害因素复杂。本文针对电子行业女工的用工特点、职业危害暴露与防护、职业病发病情况、生殖健康与心理健康影响、职业健康管理等方面进行了综述，需要重点关注电子行业女工的生殖、心理健康等问题。另外，女工的卫生防护水平低，更需要通过政策和制度来促进电子行业女工健康促进和管理的开展。. | zh-cn |
pair_29429281 | Alveolar and cystic echinococcosis are important zoonotic diseases caused by the dog/fox tapeworms of Echinococcus granulosus and E. multilocularis, which are distributed in almost whole the world. The diseases remarkably impact on the people's health and economic development of communities. Echinococcus tapeworms need... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 由细粒棘球绦虫和多房棘球绦虫引起的棘球蚴病在全世界范围内流行，严重危害了人群的身体健康和社会发展。棘球绦虫生理学特点和生理指标是设计控制方案，解决诊断、治疗和预防等方面问题的基础。棘球绦虫有其复杂的生活史，需要寄生于两个哺乳类动物，经历不同发育的阶段（成虫、虫卵、包囊和原头蚴），每个阶段都有各自不同的生理学特点。本文系统总结和归纳了棘球绦虫主要生理学特点并强调了与控制方案有关的生理学参数。从生活史可以看出，棘球绦虫有两个感染阶段，一是虫卵,它是引起人和中间宿主原发性感染的唯一阶段；二是原头蚴，唯一感染犬等终末宿主的发育阶段。虫卵产生于寄生在终末宿主小肠里的成虫，虫卵在成虫体内的成熟时限是确定对犬驱虫间隔期的生理参数。细粒棘球绦虫在犬... | zh-cn |
pair_29429282 | Corneal refractive surgery, as one of the common visual correction methods, has been increasingly accepted in China. There are a large number of people in China who undergo the corneal refractive surgery due to the high incidence of myopia in the country. It is essential that the safest and most effective surgery shoul... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 角膜屈光手术作为视觉矫正方式之一，已被越来越多屈光不正患者接受。近视眼在我国的发病率较高，使得接受角膜屈光手术的患者数量庞大。面对相对健康的角膜等眼部组织，需要选择最为安全而有效的手术方式。近年来角膜屈光手术新技术不断涌现，但仍存在许多未知。本文在介绍各类新技术的同时，指出角膜屈光手术面临的问题，强调需要进行大量的临床和基础研究，包括组织病理学、分子生物学等结合数学、物理学、计算机学、化学以及角膜生物力学等，通过多学科相互交叉、渗透，才能更加深入了解新技术的内涵及本质，正确掌握和选择手术方式，使角膜屈光手术达到组织损伤最小，从而获得最佳的临床视觉矫正效果。<i>（中华眼科杂志，2018，54：3-6）</i>. | zh-cn |
pair_29429283 | With the development of excimer laser and femtosecond laser equipment, application of diversified and customized surgical decision in modern corneal refractive surgery has been an inevitable trend. However, how to make a personalized decision with an accurate surgical design to achieve better visual quality becomes the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着准分子激光设备和飞秒激光设备的不断研发和更新，多元化及个性化治疗已成为现代角膜屈光手术的必然趋势。但面对不同的手术设备，如何个性化选择手术方式并精准设计手术方案，以求术后获得高水平视觉质量，是临床医师和患者倍加关注的焦点问题。目前临床广泛开展的飞秒激光辅助准分子激光原位角膜磨镶术（LASIK）及飞秒激光小切口角膜基质透镜取出术孰优孰劣？应如何进行选择？本文以此为焦点，深入阐述两种术式的特点及其利弊，目的在于为临床理性地个性化选择角膜屈光手术方式，并合理及规范开展临床治疗工作提供参考。<i>（中华眼科杂志，2018，54：7-10）</i>. | zh-cn |
pair_29429290 | 3D printing is a kind of technology that makes 3D models from computer-aided designs through additive manufacturing, in which successive layers of the material are deposited onto underlying layers to construct 3D objects. In recent years, 3D printing is gradually applied in the field of ophthalmology, such as the corne... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 三维打印技术是一种在计算机辅助设计下，通过三维打印机将添加材料分层打印，最后叠加形成完整三维物体的一种累积制造技术。近年来，该技术在眼科领域中得到逐步推广，广泛用于角膜和视网膜研究、眼眶手术、眼肿瘤放射治疗、眼科植入物和眼科教学等方面。本文就三维打印技术在眼科临床和基础研究方面的应用进行综述，以期为临床开展相关工作提供参考。<i>（中华眼科杂志，2018，54：72-76）</i>. | zh-cn |
pair_29429291 | Dry eye has become the most common ophthalmic disease besides ametropia. As a chronic ophthalmic disease, dry eye, which in serious cases might even lead to blindness, not only affects the life quality of the patient, but also poses adverse impact on social productivity and work efficiency, and moreover influences the ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目前干眼已成为除屈光不正以外临床最常见的眼科疾病。作为一种慢性眼科疾病，干眼不仅影响患者的生活质量，严重者甚至致盲，影响社会生产力和工作效率，进而影响社会经济的发展。近年来由于视频终端的广泛使用，干眼的发病率进一步上升，这使我们面临更大的挑战。为此本文通过阐述干眼的危害及其对社会经济的影响，提出对干眼进行慢性疾病管理的概念和重要性，以期临床给予关注和重视，提前谋划，满足我国干眼患者的需求。<i>（中华眼科杂志，2018，54：81-83）</i>. | zh-cn |
pair_29429292 | Making oneself more beautiful has always been part of humans' civilized life. Accordingly, the side effects of various cosmetic product and cosmetic procedure long exist. The ocular-surface problems induced by cosmetology mainly include cornea and conjunctiva damages, and tear film damages. Specifically, cornea and con... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 人类对外貌改善的需求一直以来都是社会生活及文化的重要组成部分，相应的各种美容产品和美容手段所带来的不良作用也如影随形。现有的美容产品及技术引起的眼表问题主要分为对角结膜的损伤和对眼表泪膜的破坏。角结膜损伤包括不规范操作造成的物理性损伤、美容产品自身的不良反应、美容性角膜接触镜引起的感染等。眼表泪膜的破坏主要包括眼睑解剖学结构破坏、泪腺分泌功能下降、睑板腺腺体及功能受损等。通过从眼科的角度揭示美容所致眼表疾病的现状、原因及预防措施，警示临床应关注并积极预防眼部美容和化妆造成的眼表损伤。<i>（中华眼科杂志，2018，54：84-86）</i>. | zh-cn |
pair_29429299 | Intense pulsed light (IPL) is a broad spectrum incoherent light which is produced by high-output xenon lamp. Since the invention of the first-generation IPL in 1994, IPL technology has been developing rapidly and extensively utilized in multiple fields relevant to dermatology across the world. In 2004, the fourth-gener... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 强脉冲光是指高输出功率氙灯产生的宽谱非相关光。自1994年第一代强脉冲光技术推出后，该技术迅速发展，推广至皮肤科多个领域。2004年优化脉冲技术被推出后，强脉冲光更是在全世界美容领域得到广泛应用。2002年Toyos发现经过强脉冲光治疗后的酒糟鼻患者的睑板腺功能障碍及干眼症状得到了明显改善，开始将强脉冲光应用于眼科领域。近年来临床研究显示，强脉冲光可以明显改善睑板腺功能障碍及其相关干眼患者的眼部症状及体征。但相关研究较少，且作用机制尚不完全清楚，仍需更加深入的研究。本文阐述了强脉冲光的临床应用历程、一般作用原理以及治疗睑板腺功能障碍及蒸发过强型干眼的相关应用。<i>（中华眼科杂志，2018，54：140-143）</i>. | zh-cn |
pair_29429300 | Dry eye is one of the most common ocular problems in ophthalmology clinic. With the change of social environment and people's life style, the prevalence of dry eye disease is increasing. Currently, the diagnosis criteria for dry eye is controversial, diagnosis of dry eye mainly rely on the comprehensive assessment of s... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 干眼是眼科门诊常见病。随着周围环境和生活方式的改变，该病的发生率逐年升高。目前尚无干眼的诊断金标准，主要依靠结合患者症状、体征进行综合评估。然而干眼症状体征分离现象常给临床诊疗带来压力。近年来的研究发现，干眼感觉神经性疼痛在干眼症状体征分离现象中的作用不可忽视。本文就疼痛的概念、眼表神经的分布与功能、疼痛的发生机制、干眼疼痛的流行病学及镇痛治疗等方面进行简要综述。<i>（中华眼科杂志，2018，54：144-148）</i>. | zh-cn |
pair_29429301 | Dry eye disease (DED) is the most common ocular surface diseasenowadays. DED can be divided into different types based on the pathogenesis. The progression of DED is strongly related to chronic ocular surface inflammation, regardless of the type of DED. The corneal Langerhans cells (LC) are the dedicated antigen presen... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 干眼为目前发病率最高的眼表疾病，其核心病理机制为泪液渗透压升高及眼表慢性炎性反应。角膜朗格汉斯细胞是眼表免疫系统中的专职抗原提呈细胞，随着认识的深入，逐步发现其在眼表疾病过程中的双面性，既可进行抗原吞噬导致免疫耐受，又可完成抗原呈递导致免疫激活，进而引起效应T细胞放大炎性反应。以往对干眼炎性反应机制方面的研究主要着重于T淋巴细胞的作用，而对角膜朗格汉斯细胞研究较少。但实际上，角膜朗格汉斯细胞的功能状态对眼表免疫过程的发生、发展及转归有着深刻的影响。本文将对近年来角膜朗格汉斯细胞在干眼发病机制方面的研究进展进行总结，以期为临床开展相关研究提供参考。<i>（中华眼科杂志，2018，54：149-153）</i>. | zh-cn |
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