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pair_33191706
To summarize the research progress of osteonecrosis of femoral head (ONFH) following femoral intertrochanteric fractures in adults. Relevant literature at home and abroad was extensively reviewed to summarize the pathogenesis, high-risk factors, and treatment of ONFH after femoral intertrochanteric fracture in adults. ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
总结成人股骨转子间骨折术后股骨头坏死(osteonecrosis of femoral head,ONFH)研究进展。. 广泛查阅国内外相关文献,总结成人股骨转子间骨折术后 ONFH 发病机制、高危因素及治疗方式。. 股骨转子间骨折术后 ONFH 多发生在术后 2 年内,发生率较低。目前认为高能量损伤导致的粉碎骨折及移位较大的骨折、接近基底部的骨折类型、患肢过度外旋畸形、髓内钉进针点不当,以及术中可能影响旋股内侧动脉深支血供的暴力操作,是导致股骨转子间骨折术后 ONFH 的高危因素。坏死后治疗以髋关节置换为主,可取得良好效果。. 针对以上风险,伤后要避免过度外旋、过度牵引、暴力操作,术中要解剖复位,进针点精确,避免反复钻孔,导致热损...
zh-cn
pair_33191707
To review the evaluation method of paraspinal muscle and its role in lumbar spine diseases, and offer reference for further research on paraspinal muscles. The related literature of paraspinal muscle measurement and its role in lumbar spine diseases was reviewed. The evaluation methods of paraspinal muscle were analyze...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
对椎旁肌评价方法及其与腰椎疾病发生发展的关系进行综述,为进一步开展椎旁肌相关研究提供参考。. 广泛查阅国内外关于椎旁肌评价方法及椎旁肌在腰椎疾病中作用的相关文献,对常用的椎旁肌评价方法优点和局限性、椎旁肌与腰椎疾病的关系等方面进行总结。. 临床常用 CT、MRI 评估椎旁肌退变,检测指标包括椎旁肌横截面积及脂肪浸润程度。影像学测量方法可重复性好,但是 CT 存在辐射暴露缺点,MRI 花费较高。此外,椎旁肌功能也逐渐得到学者关注,主要评价方法有表面肌电信号分析以及腰背肌力量测试。表面肌电信号分析能够定量反映神经肌肉功能,但是测量结果影响因素较多;腰背肌力量测试简单,但缺乏标准化动作。研究表明椎旁肌退变与多种腰椎疾病相关,但不同研究结果...
zh-cn
pair_33191708
To review the advances in the application of tranexamic acid (TXA) in adolescent spinal corrective surgery. The mechanism of action and pharmacokinetic, effectiveness, dosage, safety as well as methods of administration were comprehensively summarized by consulting domestic and overseas related literature about the app...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
总结氨甲环酸(tranexamic acid,TXA)在青少年脊柱矫形术中的应用研究进展。. 查阅国内外 TXA 在青少年脊柱矫形术中应用的相关文献,从其作用机制及药代动力学特点、具体疗效、使用剂量、给药方式及安全性等方面进行总结分析。. TXA 可以降低青少年脊柱矫形术中失血量、输血率、输血量及术后引流量。目前,青少年脊柱矫形术中给药方式主要采取麻醉诱导或切皮前静脉给予负荷剂量、随后给予维持剂量至手术结束,负荷剂量和维持剂量的范围分别为 10~100 mg/kg 和 1~10 mg/(kg·h),按此剂量给药暂未见药物相关不良事件报道。. 在青少年脊柱矫形术中应用 TXA 的有效性及安全性已基本得到证实,但最佳给药剂量、给药方式以...
zh-cn
pair_33191709
To summarize the research progress of ureteral injury in oblique lumbar interbody fusion (OLIF). The literature about incidence, clinical manifestations, diagnosis, and treatment of ureteral injury complications in OLIF was reviewed. OLIF surgery poses a risk of ureteral injury because its surgical approach is anatomic...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
总结斜外侧腰椎椎间融合术(oblique lumbar interbody fusion,OLIF)输尿管损伤并发症的研究进展。. 广泛查阅近年国内外相关文献,对 OLIF 手术输尿管损伤发生率、临床表现、诊断和治疗方法进行总结。. OLIF 手术通道在解剖学上与左侧输尿管相毗邻,因此存在输尿管损伤风险。术中输尿管损伤常较隐匿,临床表现无特异性,CT 尿路造影是常用的诊断方法。输尿管损伤的治疗方式取决于诊断时间、损伤位置及程度等多种因素,治疗方法涵盖内镜治疗、替代物重建等多种修复手段。. OLIF 术中应提高警惕,注意勿损伤输尿管,并及时发现异常情况。熟悉输尿管解剖、术中强调轻柔操作等对于预防输尿管损伤具有重要意义。.
zh-cn
pair_33191710
The antibacterial properties of porous medical implant materials were reviewed to provide guidance for further improvement of new medical implant materials. The literature related to the antibacterial properties of porous medical implant materials in recent years was consulted, and the classification, characteristics a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
None
zh-cn
pair_33191711
To summarize the regulatory effect of long non-coding RNA (lncRNA) on osteoarthritis (OA) cartilage injury. The molecular functions and mechanisms of lncRNA were introduced and its regulatory effects on the pathological processes of OA were elaborated by referring to the relevant literature at domestic and abroad in re...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
总结长链非编码 RNA(long non-coding RNA,lncRNA)在骨关节炎(osteoarthritis,OA)软骨损伤中的调控作用。. 广泛查阅近年国内外相关文献,介绍 lncRNA 的分子功能和作用机制,并详细阐述其对 OA 病理过程的调控作用。. OA 病理特征是关节软骨退变和滑膜组织炎症,但其病因和病理机制尚未明确。lncRNA 是一类异质性非编码 RNA,在许多炎症相关疾病中起调控作用并且发挥广泛的生物学功能。lncRNA 是参与 OA 发病机制的调节器,在 OA 软骨中异常表达,从而导致软骨细胞外基质变性。. 目前对于 lncRNA 调控 OA 的病理作用及软骨细胞生物学功能已有初步研究,但 lncRNA ...
zh-cn
pair_33197990
As the approaching of autumn and winter in northern hemisphere, COVID-19, mainly transmitted through respiratory droplets and close contact, has posed new challenge to the countries across the world. This paper summarizes the current status of COVID-19 pandemic and related responses performed in terms of the variation ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
随着北半球秋冬季节来临,以呼吸道飞沫和密切接触传播为主要途径的新型冠状病毒肺炎(新冠肺炎,2019冠状病毒病)给各国防控带来了新的挑战。本文从新冠病毒变异、全球流行形势、群体免疫问题、无症状感染对我国疫情防控的影响、疫苗的进展和治疗等方面对新冠肺炎流行及应对现状进行综述,以期为新形势下我国疫情防控策略的规划和调整提供借鉴。.
zh-cn
pair_33200507
Several studies have suggested that nonalcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease (CVD). The excretion of low-level albuminuria (LLA) elevates as the prevalence of CVD increases. However, few studies have explored the association between NAFLD and LLA. This cross-sectional study inc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景: 有多项研究表明; 非酒精性脂肪肝(NAFLD)与心血管疾病(CVD)有关。低水平蛋白尿(LLA)的排泄随着CVD患病率的升高而增加。但是; 少有研究探索NAFLD和LLA之间的相关性。 方法: 这项横断面研究包括31 147名中国成年人(7664名男性和23 483名女性)。由尿白蛋白与肌酐之比(UACR)确定白蛋白尿的“正常”水平为低于30 mg / g。 LLA被定义为“正常”蛋白尿范围内的较高水平(5.54 mg / g <LLA≤29.9mg / g)。NAFLD的定义为脂肪肝指数(FLI)≥60。FLI使用Bedogni方程计算。 结果: 通过多变量线性回归分析; UACR与FLI之间存在正相关(非标准化β±SE:...
zh-cn
pair_33200833
To systematically examine the effectiveness of music therapy on preterm infants in neonatal intensive care unit. In recent years, the application of music therapy for preterm infants in neonatal intensive care unit has attracted more and more attention because of its clinical effects. However, there still exist dispute...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 系统性地检查音乐疗法对新生儿重症监护室内的早产儿的效果。 背景: 近年来,由于临床效果显著,音乐疗法对于新生儿重症监护室内早产儿的应用受到越来越多的关注。然而,不同的研究之间仍存在争议。 设计: 采用系统评估和荟萃分析。 数据来源: 对11个数据库自1910年至2019年11月4日期间的数据进行检索。 评估方法: 根据RPISMA指南选择用于分析的论文。通过Review Manager 5.3软件进行荟萃分析。 结果: 共涉及13次试验以及1,093位参与者。荟萃分析显示,音乐疗法对早产儿心率、呼吸频率、经口喂养量、压力水平以及母亲焦虑度有显著影响,各研究间存在中等到高度异质性。但音乐疗法对氧饱和度和行为状态并无影响。 结论...
zh-cn
pair_29357966
Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors. A retrospective analysis of The Chinese Alliance...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 胸腺瘤常伴发重症肌无力(myasthenia gravis, MG),但是这些患者行胸腺切除的预后与MG的关系尚不明确。本研究旨在探讨影响胸腺瘤合并MG患者预后的因素。方法 回顾性分析中国胸腺瘤协作组(Chinese Alliance for Research of Thymoma, ChART)数据库1992年-2012年875例随访20年资料完整的胸腺瘤病例,分析世界卫生组织(World Health Organization, WHO)组织学分型、Masaoka分期、术后辅助治疗与MG及预后的关系。结果 胸腺瘤WHO组织学分型与MG有相关性,差异有统计学意义(χ²=24.908, P<0.001)。MG发生率为22...
zh-cn
pair_29357968
Malignant pleural effusion (PE) was generally defined as pleural effusion containing tumors with poor prognosis. Some kinds of undefined pleural effusions due to too small amount of effusion had poor prognosis too. This study aimed to analyze the clinical characteristics and prognostic factors of patients who suffered ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 一般将含有肿瘤细胞的胸水称为恶性胸水,预后差,因量少而无法定性胸水预后同样较差。本研究分析合并胸腔积液局限期小细胞肺癌患者的临床特点、预后因素。方法 回顾性分析了2007年10月-2016年1月期间于我院诊断为局限期小细胞肺癌542例患者,对其中初诊含有胸水患者109例的临床特点及生存时间、预后因素进行分析。主要观察指标为总生存期及无进展生存期。结果 全组患者中位总生存期、中位无进展生存期分别为29.4个月、18.2个月。治疗前合并胸水的患者较无胸水者生存期明显缩短(中位OS 21.0个月 vs 31.7个月,中位PFS 14.1个月 vs 19.1个月;Log-rank P=0.001, P=0.014),Cox多因素...
zh-cn
pair_29357969
Non-small cell lung cancer with left atrial tumor thrombus accounts for a small proportion of local advanced lung cancer. Whether surgery could bring benefits, as well as surgical options are still controversial, and have always been hot spots in surgical research. We report a single center experience of surgical treat...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 非小细胞肺癌合并左房瘤栓病例在局部晚期肺癌中占有一定比例,积极外科手术能否带来获益,以及具体术式选择均存在争议,是目前外科研究的热点。我们报告了单中心接受手术治疗的非小细胞肺癌合并左房瘤栓病例队列,结合预后分析探究合理的诊疗方法。方法 自2006年8月-2017年7月共有11例非小细胞肺癌合并左房瘤栓病例在中日友好医院胸外科确诊并行手术治疗,对其临床资料、治疗选择、病理类型、预后情况进行了回顾性研究。结果 11例患者中,男性7例,女性4例,平均年龄57.9岁,6例患者接受术前新辅助放化疗。全部患者手术过程顺利,其中行正中开胸体外循环下手术3例,体外膜肺氧合辅助下后外侧切口入路手术1例,常规后外侧切口入路手术6例,胸腔镜辅...
zh-cn
pair_29357971
Epidermal growth factor receptor (EGFR) mutation non-small cell lung cancer (NSCLC) is an important subtype of lung cancer. The incidence of malignant pericardial effusion (MPCE) in EGFR-mutant NSCLC patients is high. However, there are few researches on the treatmentof this type of patients. We collected data on clini...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 表皮生长因子受体(epidermal growth factor receptor, EGFR)突变的非小细胞肺癌(non-small cell lung cancer, NSCLC)是肺癌的一个重要亚型。EGFR突变的NSCLC患者合并恶性心包积液的发生率较高,但目前针对此型肺癌患者治疗方案的研究较少。方法 本研究对我院2010年1月-2016年12月期间确诊的EGFR敏感突变的NSCLC合并恶性心包积液患者的临床资料和治疗情况进行回顾性分析,具体分为以下三组治疗模式:口服吉非替尼联合心包灌注羟基喜树碱组(吉非替尼/HCPT),静脉化疗联合心包灌注羟基喜树碱组(化疗/ HCPT)及吉非替尼单药组,探讨不同治疗模式患者病...
zh-cn
pair_29357972
Lung cancer is one of the most important malignant tumors in the world. The morbidity and mortality rank the first in all kinds of cancer. Long non-coding RNA (lncRNA) is at least 200 nt long and has no protein coding capacity. It plays an important role in the epigenetic regulation, cell cycle regulation, the regulati...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
肺癌是世界上常见的恶性肿瘤之一,其发病率和死亡率都居全部恶性肿瘤的首位。长链非编码RNA(lncRNA)是一类转录长度超过200个核苷酸且无蛋白质编码功能的RNA,但在表观遗传学调控、细胞周期调控和细胞分化调控等众多生命活动中发挥重要作用。研究发现lncRNA在非小细胞肺癌(non-small cell lung cancer, NSCLC)组织和血液中异常表达,且对肿瘤细胞的增殖、迁移、侵袭和凋亡发挥了重要调节作用,与肿瘤的发生发展密切相关。探索lncRNA在NSCLC中的作用机制,有助于NSCLC的早期诊断,靶向治疗及改善预后。因此本文就lncRNA与NSCLC的发生、诊断、治疗和预后的最新研究进展做一阐述,以期为NSCLC的防...
zh-cn
pair_29357973
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death in China. In recent years, therapies for oncogenedrivers and immune checkpoints have proved inspiring. Circular RNA (circRNA), which is a kind of RNA with covalent ring structure relating to stages and metastasis of cancer, has many...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
肺癌(lung cancer)的发病率及死亡率在我国双居首位,近年来针对肿瘤驱动基因和免疫检查点的靶点治疗取得了振奋人心的成果。环状RNA(circular RNA, circRNA)是一类具有环形结构的RNA分子,研究发现其与肿瘤的分期、淋巴结转移等关系密切,在生理过程和疾病中具有特殊的生物学功能。其高度稳定性和特异性使之有望成为肿瘤潜在的预测和治疗靶点。目前环状RNA在肺癌中的生物学功能和调控机制仅有少量研究报道。本文对环状RNA的研究历史、生源机制、生物学功能以及其在肿瘤,尤其是肺癌研究中的进展作一综述,以期为环状RNA在肺癌中的研究提供理论依据和新的思路。.
zh-cn
pair_29357974
With high morbidity and mortality, lung cancer is a major threat to human health and one of the focuses of tumor researches. Lung cancer stem cells (LCSCs) are regarded as a subpopulation of cells within lung cancer tissues with the capacity of self-renewal and differentiation, and might be related to tumorigenesis and...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
肺癌发病率高、死亡率高,严重威胁人类健康,是肿瘤研究的热点之一。肺癌干细胞是指存在于肺癌组织中的一类细胞亚群,具有自我更新及分化能力并可能导致了肿瘤发生及肿瘤异质性的产生。肺癌干细胞理论可以解释肺癌复发、转移、抗化疗药物等特性,针对这类细胞的靶向治疗有一定的运用前景。本文简要介绍肺癌干细胞的标志物、其异常的信号通路等,并概述靶向肺癌干细胞的治疗策略。.
zh-cn
pair_29363737
There is growing recognition that caring for a patient with schizophrenia often results in high levels of perceived burden and poorer overall mental health for caregivers. A quantitative cross-sectional design and standardized instruments were used to collect data from 355 primary caregivers of adults in outpatient car...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
人们逐渐意识到照顾一个精神分裂症患者经常会导致照料人高水平感知到的负担和整体精神健康下降。我们使用一个定量横截设计和标准工具来收集来自中国335位成年精神分裂症门诊病人主要照料人的数据。基于综合压力视角,我们使用结构等式模型来考察照料人负担和主要照料人精神健康之间的关联以及这一关联是否受个性,应对风格以及家庭功能的影响。拟合优度指标(χ<sup>2</sup> /df = 1.406, GFI = 0.919, CFI = 0.957, etc.) 确认调整后模型和数据吻合。我们发现照料人负担直接而且明显和精神健康结果相关,这和综合压力模型以及该研究假设一致。最终模型显示人格特点,应对风格,以及家庭功能影响照料人负担和精神健康之间的...
zh-cn
pair_29363737
There is growing recognition that caring for a patient with schizophrenia often results in high levels of perceived burden and poorer overall mental health for caregivers. A quantitative cross-sectional design and standardized instruments were used to collect data from 355 primary caregivers of adults in outpatient car...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Cada vez se reconce más que cuidar a un paciente con esquizofrenia generalmente resulta en niveles altos de sobrecarga percibida y en una peor salud mental general para los cuidadores. Se utilizó un diseño transversal cuantitativo e instrumentos estandarizados para recopilar datos de 355 cuidadores principales de adult...
es
pair_29363754
Guided by a process model of parenting and the integrative model, this study examined sources of emotional support (i.e., partner, maternal, paternal) as related to stress and satisfaction resulting from the parenting role in a sample of Mexican-origin young adult parents who participated in the National Longitudinal S...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
基于一个亲职过程模型和一个整合模型,该研究考察了在由参与第4阶段全国青少年和成人健康纵向研究的墨西哥裔年轻家长构成的样本中情感支持来源(例如伴侣,母亲,父亲)和源于亲职角色压力和满意度的关联。参与者是有孩子和伴侣的男性和女性家长(年龄在26-35岁间;59%女性;N = 737)。结构等式模型结果显示来自母亲的支持突出;高水平的母亲支持和高水平亲职满意度相关。间接效果测试显示亲职满意度在母亲支持和亲职压力之间关联上扮演干预性角色。结果模式在不同语言适应一致,在不同性别之间有差异。理解在墨西哥裔人群中预测亲职压力和满意度的机制可能帮助我们确定文化敏感干预策略。.
zh-cn
pair_29363754
Guided by a process model of parenting and the integrative model, this study examined sources of emotional support (i.e., partner, maternal, paternal) as related to stress and satisfaction resulting from the parenting role in a sample of Mexican-origin young adult parents who participated in the National Longitudinal S...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Guiado por un modelo de proceso de la crianza y por el modelo integrador, el presente estudio examinó las fuentes de apoyo emocional (p. ej.: de la pareja, materno, paterno) en relación con el estrés y la satisfacción resultantes del rol de crianza en una muestra de padres adultos jóvenes de origen mexicano que partici...
es
pair_29365387
In the past few decades, considerable development was achieved in the cochlear implantation following the emergence of innovative electrode array and advances in minimally invasive surgery. Minimally invasive technique led to a better preservation of residual low-frequency hearing. The loss of residual hearing was caus...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在过去的几十年间,随着革新性耳蜗电极的出现和微创手术技术的进步,人工耳蜗植入手术取得了巨大的发展。微创人工耳蜗植入技术的应用让更好地保留低频残余听力成为可能。残余听力受损可由多因素引起,已有的研究表明,较缓慢地匀速植入电极和围手术期糖皮质激素的应用对听力保留有积极作用,但不同植入电极类型及植入径路对残余听力的保留并未体现出明显差异。.
zh-cn
pair_29365388
Upper airway patency closely contact with neuromuscular airway regulation during respiratory, especially the activity of the pharyngeal dilators. The genioglossus is the largest pharyngeal dilators with its contraction playing the most important role in keeping the pharyngeal airway open. In healthy individuals, geniog...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
正常呼吸运动中,上气道通畅性的维持与其对应扩张肌的神经肌肉调节活动密不可分,其中颏舌肌(genioglossus,GG)作为最大的上气道扩张肌,其开放上气道的作用最大。在健康个体中,颏舌肌的激活与上气道塌陷和咽腔阻力呈负相关性,吸气过程中的腔内负压可激活气道内机械感受器引发反射性肌肉活动,产生补偿性气道扩张。而在阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)患者,其颏舌肌的肌肉补偿作用并不能正常抵消气道负荷以维持通畅性,导致频繁出现阻塞性呼吸事件。已有多项研究显示,OSA患者睡眠期间上气道的易塌陷性与颏舌肌肌电(genioglossus electromyography,GGEMG)变化特点密切相关。本...
zh-cn
pair_29365389
The length of tracheal defect or stenosis exceeded 5 cm could not be treated by simple resection and end-to-end anastomosis of the remaining trachea. Various ways of tracheal replacement had appeared sequentially, such as radial forearm free flap with cartilage grafts, tracheal tissue-engineering and tracheal allotrans...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
气管缺损或狭窄长度超过5 cm无法用常规的气管切除和端端吻合方法治疗。各种气管替代治疗,如带软骨的桡侧前臂皮瓣、气管组织工程、气管移植等相继出现。在这些方法中,气管移植显示出较好的远期效果。本文综述了气管移植研究进展,重点在移植气管的再血管化和再上皮化,以及免疫抑制剂应用等方面。.
zh-cn
pair_29365410
Cancer is a major chronic disease threatening the people's health in China. We reviewed the latest advances on cancer surveillance, prevention and control in our country, which may provide important clues for future cancer control. We used data from the National Central Cancer Registry, to describe and analyze the late...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
癌症是影响中国居民健康的主要慢性病之一。本文综述中国癌症监测及防治的阶段性进展,为今后中国癌症防治工作提供参考。通过对中国癌症的流行状况和趋势进行描述分析,结合目前防治工作的进展,总结在政策制订、防治网络建设、监测体系建立、癌症预防等领域取得的成绩和所面临的挑战,提出下一步工作建议。中国居民癌症负担总体呈上升趋势。2014年,中国新发癌症人数约380.4万,全国癌症标化发病率为190.63/10万,死于癌症人数约229.6万,癌症标化死亡率为106.98/10万。癌症防治体系已逐渐建立并完善,已在全国范围内开展人群癌症监测数据收集,数据质量不断提高,覆盖面不断增加。随着人口老龄化趋势加剧及不良生活方式的广泛存在,中国癌症负担不容忽视...
zh-cn
pair_29365420
Single arm trial (SAT) was widely used for new drug application (NDA) of novel anti-cancer drugs in recent years. The listing time was greatly shortened by SAT while comparing with randomized controlled trials (RCT). Thus, the companies intended to get NDA through SAT. To encourage innovation and accelerate the develop...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
近年来单臂试验被越来越多地用于抗肿瘤新药的注册申请。与随机对照试验比较,单臂试验显著缩短了药品的上市时间,因此企业均期望以单臂数据支持新药注册。为鼓励创新,加速抗肿瘤药物研发,文章从单臂试验的产生背景、核心问题以及单臂试验支持注册的标准等方面,系统阐述了抗肿瘤药物单臂试验的设计和原则。.
zh-cn
pair_29365422
Hereditary colorectal cancer can be divded into two categories based on the presence or absence of polyps. The first category is characterized by the development of polyposis, which includes familial adenomatous polyposis (FAP); The second category is nonpolyposis colorectal cancer, which is represented by Lynch syndro...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
遗传性结直肠癌根据有无息肉大致可分为2类,第1类是以息肉病为特征,包括家族性腺瘤性息肉病(FAP)等;第2类为非息肉病性结直肠癌,Lynch综合征是其中的重要代表。本共识主要分为遗传性非息肉病性综合征、息肉病性综合征以及遗传咨询与基因检测等3部分,分别针对各个遗传综合征的定义、临床病理特征、诊断标准、治疗策略以及随访监测策略展开阐述和推荐。除了提供相应的诊断和治疗方案,更强调防治结合,注重对家系成员的遗传筛查和监测随访。希望通过专家共识的制订,推动全国临床工作者对遗传性结直肠癌的认识和多学科参与的规范化诊治,最终有效提高中国遗传性结直肠癌的临床诊治和家系管理水平。.
zh-cn
pair_29372007
Numerous reports indicate that the incidence of posttraumatic stress disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) military personnel has created a significant behavioural healthcare challenge. These findings have served to motivate research on how to better deve...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
大量报道指出创伤后应激障碍(PTSD)在‘持久自由据军事行动/伊拉克自由军事行动/新曙光军事行动(OEF/OIF/OND)’的军队人员中的发生率已经给行为医疗护理带来了不容忽视的的挑战。这些发现有助于鼓励对如何更好发展和推广 PTSD 治疗进行研究。这篇文章基于南加里佛利亚大学创造性技术研究所从2004年开始 VR 项目,展示了使用虚拟现实(VR)作为临床工具来解决评估、干预和 PTSD 治疗的问题。首先是关于 VR 临床使用的定义和原理的简短讨论,然后描述VR 在延长暴露治疗(PE)的应用。这个治疗用于患有战争和性侵犯相关的 PTSD 的服务人员(SMs)和老兵。之后呈现了对这项技术扩展应用:使用虚拟治疗模拟伊拉克和阿富汗场景进行...
zh-cn
pair_29372007
Numerous reports indicate that the incidence of posttraumatic stress disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) military personnel has created a significant behavioural healthcare challenge. These findings have served to motivate research on how to better deve...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Numerosos informes indican que la incidencia del trastorno por estrés postraumático (TEPT) en el personal militar de Operación Libertad Duradera/Operación Libertad Iraquí/Operación Nuevo Amanecer (OEF/OIF/OND, por sus siglas en inglés) ha generado un reto significativo en la atención de la salud conductual. Estos halla...
es
pair_29372010
The 11th revision to the World Health Organization's International Classification of Diseases (ICD-11) proposes two distinct sibling conditions: Posttraumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD). In this paper, we aim to provide an update on the latest research regarding the conceptual structure and measure...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
世界卫生组织发布的第11版国际疾病分类(ICD-11)提出了两种不同但相仿的疾病:创伤后应激障碍(PTSD)和复杂PTSD(CPTSD)。在本文中,我们目标是更新关于 PTSD和 CPTSD 在概念结构和测量上的研究进展。我们在英国、美国、德国和立陶宛根据 ICD-11使用国际创伤问卷(ITQ)。初步研究发现显示 CPTSD 在临床和普通人群中普遍存在,尽管在不同国家之间的流行率可能有所不同。在临床样本中,初步证据显示 CPTSD 比 PTSD 更加常见,同时也支持ITQ 分数可以有效可靠地区分 PTSD 和 CPTSD。未来还需要横向研究探索 PTSD 和 CPTSD 在不同国家之间的流行率、发生率和预测指标的区别。.
zh-cn
pair_29372010
The 11th revision to the World Health Organization's International Classification of Diseases (ICD-11) proposes two distinct sibling conditions: Posttraumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD). In this paper, we aim to provide an update on the latest research regarding the conceptual structure and measure...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La 11ª revisión de la Clasificación Internacional de Enfermedades (CIE-11) de la Organización Mundial de la Salud propone dos afecciones hermanas distintas, el trastorno por estrés postraumático (TEPT) y el TEPT Complejo (TEPT-C). En este artículo, nuestro objetivo es proporcionar una actualización sobre las últimas in...
es
pair_29372012
The bulk of the literature on effective treatments for posttraumatic stress disorder (PTSD) has focused on children, adolescents, and young adults. The evidence on treatments for older adults is sparse. This case report presents the application of narrative exposure therapy (NET) for a 70-year-old Norwegian woman suffe...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
大量文献对创伤后应激障碍(PTSD)的有效治疗集中在儿童、青少年和年轻成人。关于老年的治疗证据非常少见。这个个案报告呈现了应用叙事暴露疗法(NET)对一个70岁的因多种童年创伤和晚年生活创伤事件而患有 PTSD的挪威女性进行治疗。NET 是一个手册化的、短程的、针对PTSD 的认知行为疗法。最初是为了治疗战争幸存者和机构暴力而开发的。NET 的某些方面(包括它的简洁、简单和具体)可能适合更年老的成人。治疗的过程包括心理教育、生命线练习,想象暴露和创作连贯叙事。抑郁和创伤后应激症状在治疗过程以及治疗后得到改善。这说明 NET 可能有治疗年老成人创伤的潜力。.
zh-cn
pair_29372012
The bulk of the literature on effective treatments for posttraumatic stress disorder (PTSD) has focused on children, adolescents, and young adults. The evidence on treatments for older adults is sparse. This case report presents the application of narrative exposure therapy (NET) for a 70-year-old Norwegian woman suffe...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La mayor parte de la literatura sobre tratamientos efectivos para el trastorno de estrés postraumático (TEPT) se ha centrado en niños, adolescentes y adultos jóvenes. La evidencia sobre tratamientos para adultos mayores es escasa. Este informe de caso presenta la aplicación de la terapia de exposición narrativa (NET, p...
es
pair_29372015
In this paper we present a description of the Horizon2020, Marie Skłodowska-Curie Action funded, research and training programme CONTEXT: COllaborative Network for Training and EXcellence in psychoTraumatology. The three objectives of the programme are put forward, each of which refers to a key component of the CONTEXT...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
这篇文章中我们描述了一个新的研究和训练项目 CONTEXT(COllaborative Network for Training and EXcellence in psychoTraumatology),由‘地平线2020:玛丽·居里·斯克洛多夫斯卡行动’资助。这个项目提出了三大目标,每个目标都指向 CONTEXT项目的主要成分之一。首先,我们总结了12个独立的研究项目,它们将在三个主要人群中开展:(1)难民和庇护寻求着,(2)现场急救员,(3)童年暴力和性别暴力的施害者和受害者。其次,我们仔细叙述了 CONTEXT的核心督导和训练项目。最后,我们描述了这个研究和训练项目将如何贡献于心理创伤领域更好的政策、指导手册和实践。.
zh-cn
pair_29372015
In this paper we present a description of the Horizon2020, Marie Skłodowska-Curie Action funded, research and training programme CONTEXT: COllaborative Network for Training and EXcellence in psychoTraumatology. The three objectives of the programme are put forward, each of which refers to a key component of the CONTEXT...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
En este artículo presentamos una descripción de un nuevo programa de investigación y formación, Horizon2020, con fondos de Marie Skłodowska-Curie Action, llamado CONTEXT o ‘Red coordinadora para la formación y la excelencia en psicotraumatología’. Se presentan los tres objetivos del programa y cada uno de los cuales ha...
es
pair_29374886
Evidence-based medicine remains the best paradigm for medical practice. However, evidence alone is not decisions; decisions must also consider resources available and the values of people. Evidence shows that most of those treated with blood pressure-lowering, cholesterol-lowering, glucose-lowering and anti-cancer drug...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
循证医学仍是当今最好的医学实践模式。需要注意的是,证据本身不等于决策,决策还必须考虑现有资源和人们的价值取向。证据显示,绝大多数患者不会因使用降血压、降血脂、降血糖、抗癌药而预防重要并发症或死亡,说明现代医学的很多诊断和治疗都不精准,找到那几个为数不多的对治疗有反应的患者就成了现代医学的梦。精准医学应运而生,但它并不是新概念,也不等于孤注一掷的基因测序。精准医学依赖的大队列多因素研究由来已久,也不是新方法。医学一直在寻求精准,而且在人类认知的各个层面都有所建树,如疫苗和抗体、血型与输血、影像对病灶的定位以及白内障晶体替换手术。基因不是达到精准的唯一途径,只是提供了新的可能性。但是多数基因和疾病关联强度很低,说明基因精准指导防治的价值...
zh-cn
pair_29374903
In the studies of modern epidemiology, exposure in a short term cannot fully elaborate the mechanism of the development of diseases or health-related events. Thus, lights have been shed on to life course epidemiology, which studies the exposures in early life time and their effects related to the development of chronic...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
现代流行病学研究中,疾病或健康相关事件的发生常难以完全用短期的暴露状态来解释。生命历程流行病学着眼于生命早期阶段的暴露因素对个人整个生命历程中的健康或疾病状况所产生的长期影响,并逐渐得到重视。当对暴露因素的病因机制及其通过其他因素产生的作用大小进行分析时,由于时间因素的存在,传统统计分析方法难以满足生命历程流行病学中病因分析的需求。本文概述了能用于生命历程病因分析的动态路径分析方法,包括该模型的结构、意义及其在生命历程流行病学病因分析中的应用。同时说明了如何准备数据、进行病因机制分析,并证明动态路径分析模型可作为生命历程流行病学中有效的病因分析工具。.
zh-cn
pair_29374904
The overall details of causality frames in the objective world remain obscure, which poses difficulty for causality research. Based on the temporality of cause and effect, the objective world is divided into three time zones and two time points, in which the causal relationships of the variables are parsed by using Dir...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
客观世界因果关系的整体框架较为笼统而缺乏明晰的细节,给因果关系的研究带来困难。本文基于因果关系的时序特性结合有向无环图(DAGs),以因和果的发生时间为界,将客观世界的时间维度划分为3个时间域和2个时间点。通过对5个时间单位上变量间存在着的完整的因果关系的病因网络DAGs进行分析发现,其病因结构由两部分叠加组成:第一部分是各个时间域间/时间点上任取一变量间的组合DAGs,为因果关系的基本结构,构成病因网络的核心,仅混杂路径影响其因果效应估计;第二部分是各个时间域内/时间点上变量间的母子或祖先-后代关系,其DAGs表现为与混杂类似的结构。本文简洁明了地构建了客观世界因果关系研究的整体框架(病因网络DAGs),解释了控制混杂以解决因果效...
zh-cn
pair_29374905
Family-based cohort study is a special type of study design, in which biological samples and environmental exposure information of the member in a family are collected and related follow up is conducted. Family-based cohort study can be applied to explore the effect of genetic factors, environmental factors, gene-gene ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
家系队列研究是一种特殊的队列研究方法,以家系为单位收集研究对象的生物样本和环境暴露信息,并进行随访,为探索复杂性疾病病因研究中遗传、环境、基因-基因和基因-环境交互作用提供重要资源。本文将对'北方农村地区居民常见慢性非传染性疾病的家系队列研究'的目标、方法、初步结果、机遇与挑战进行简单介绍。.
zh-cn
pair_29374907
Heavy metal is one of pollutants existed widely in the environment, its relationship with cardiovascular disease has attracted more and more attention. In this review, the concentrations of heavy metals, including lead, cadium and asenic, in the body from several national surveillance networks and the epidemiological s...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
重金属是重要环境污染物之一,其对心血管系统的损害已备受国内外学者的关注。本文基于重金属人体负荷水平、重金属暴露对心血管系统危害的相关研究成果,综述铅、镉、砷3种常见重金属暴露与心血管疾病关系的流行病学研究进展,并提出应加强全国范围一般人群重金属负荷水平的监测,以利于定量评估重金属暴露所致的心血管疾病风险。.
zh-cn
pair_29374943
The stationed system for detached medical officer, designated by the Royal Hanlin Department, was an important management system in the Song Dynasty for medical aid and epidemic prevention. The selection of the officers was based on the test results of the candidates. The dispatch of such medical officers was considere...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
驻泊医官制度是宋代政府进行医疗救助、疫情防控的一项重要管理措施,翰林医官院是驻泊医官的选派机构;选派时按照考试成绩高低管理,缺乏医官的州郡优先安排,并按医官供职先后顺序等综合考虑予以分遣;驻泊医官的主要职责是为所驻扎的地方军队提供医疗服务,同时在地方发生疫情时亦参与救治民众;驻泊医官任期为2年。该制度是一种较为成熟的医者管理制度,能够提高地方军队的医疗服务水平,有效防控地方疫情的发生、蔓延。.
zh-cn
pair_29374947
As an important part of paediatric science, paediatric diagnosis was in the initial stage of its development before the Song Dynasty. The main measures of diagnosing diseases were observation and pulse palpation, especially the latter. The rapid development of paediatrics in the Song Dynasty necessitated thepaediatric ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
儿科诊法是儿科学中重要的一部分。宋代以前,儿科诊法处于初步发展阶段,对小儿疾病的诊查主要运用望诊和脉诊,尤以脉诊为重。宋代儿科快速发展,儿科诊法重视目神望诊和指纹诊法,逐渐形成特色。金元时期,儿科诊法在继承前代的基础上有所发展,以望诊、脉诊并重。明清时期,儿科四诊内容不断丰富,医家注重多种诊法联合运用,使儿科诊法日趋完善。.
zh-cn
pair_29374948
Based on the living times, native places and medical works of Xin'an TCM physicians described in the <i>Xin an ming yi kao</i>(<i>Textual Research of Famous Physicians of Xin</i>'<i>an Region</i>), the geographical distribution of ancient TCM physicians was analyzed by using Excel software. It is found that Xin'an medi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
依据《新安名医考》一书中关于新安医家的生活年代、籍贯、医著3个方面的描述,利用Excel软件对历代新安医家的分布情况进行统计分析,发现在时间上,新安医学起于东晋,鼎盛于清,明清时期新安医家数量大于自东晋至明各朝代医家数量的总和;在空间上,新安医家的分布呈现东南多西北少的特征,形成以歙县、婺源、休宁3县为中心的分布区域。新安医学中心产生的原因与3县的经济发展、程朱理学的影响及人口数量密切相关。.
zh-cn
pair_29374949
Anti-opium-smoking had been the key policy of successive central and local governments from the late Qing Dynasty to the Republican Period. Since the establishment of the Nanjing Provisional Government in January 1912, the Anti-opium-smoking campaign had culminated across the country. Under the support of the governmen...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
禁烟是自清末至民国历届中央和地方政府的一项要政,特别是1912年1月南京临时政府成立后,全国各地掀起了禁烟运动的高潮。在政府支持下成立的全国性禁烟组织'中国国民禁烟会''中华国民拒毒会',为中国的禁烟运动做出了重要贡献。云南、陕西、黑龙江、浙江、上海等地方政府也结合当地的具体情况制定戒烟政策,严厉惩治大烟种植、贸易和吸食,使泛滥成灾的烟毒整体上开始得到控制。.
zh-cn
pair_29374950
In Shanxi Province, governed by Yan Xishan during the Republic of China, traditional Chinese medicine (TCM) is in a climate of relative tolerance on the whole, under its supporting policy. A TCM Improving Society was organized by Yan Xishan himself as president. Whereafter, a series of activities are carried out by the...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
民国时期阎锡山治理下的山西,整体对于中医的氛围较为宽容,采取了扶持的政策。阎锡山出面成立了中医改进研究会,并担任会长,研究会成立后所进行的一系列活动,如开办附属医院、医学传习所,创办《医学杂志》等,均得到了阎氏物力、人力的支持。阎锡山之所以扶持中医,除了其深受传统文化影响,对于中医疗效较为认同之外,更多地系基于现实情况,从山西省经济、民生等角度考虑的结果。阎锡山的措施不但为山西中医事业的发展提供了保障,也对当时全省的医疗格局产生了重要的影响。.
zh-cn
pair_29374951
As a kind of edible herbal plant, rose is recorded both in the literature of Han medicine and medicine of Uighur ethnic group, yet with different understanding on its function and different clinical application as well. Both Han and Uighur medicine maintain that rose possesses the functions of improving one's look and ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
玫瑰作为一种可'药食两用'的植物,在中医文献和维吾尔医文献中都有相关记载,但中医和维吾尔医对玫瑰功效的认识却不尽相同,临床应用也有所区别。中医、维吾尔医都认为玫瑰可美容润肤、芳香除臭、健脾调中,能治疗炎症损伤、吐血、疼痛、泄泻等症。但中医还用玫瑰治疗风痹证、乳痈乳癖、郁证等;而维吾尔医还用玫瑰治疗便秘、心悸、扁平疣、喉干等。.
zh-cn
pair_29374953
Japanese physicians of Edo Period (1603-1867) wrote many dietetic books, by combining the knowledge system (content and compiling style) and thoughts of diet therapy from China with local condition in Japan. Among them, the <i>Pao chu bei yong wo ming ben cao</i>(<i>Japanese Materia Medica Prepared for Kitchen</i>), wr...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
日本江户时代(1603-1867)的医家在借鉴中国食疗知识体系(内容及编撰形式)和汲取食疗思想的同时,还结合日本本土情况,撰写了诸多食疗类医著。其中,江户早期医家向井元升所撰《庖厨备用倭名本草》是日本最早的综合食物本草学著作。书中对日本食物本草的选择与使用带有明显本土化的色彩,涵盖食物本草的名称、形态、栽培、采摘、鉴别、性味、主治等诸多方面,体现出江户之初药食兼用思想的萌芽,同时反映了日本医家对于中国食疗思想的汲取特点,是了解江户早期日本食物本草学发展及其食疗文化的一手史料。.
zh-cn
pair_29380568
Limonene (C₁₀H₁₆) and bisabolene (C₁₅H₂₄) are both naturally occurring terpenes in plants. Depending on the number of C₅ units, limonene and bisabolene are recognized as representative monoterpenes and sesquiterpenes, respectively. Limonene and bisabolene are important pharmaceutical and nutraceutical products used in ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
柠檬烯和红没药烯均为植物天然产物,分别属于单萜类和倍半萜类化合物,能够预防和治疗癌症等多种疾病。以其作为前体物,还可以转化合成多种具有高附加值的工业产品,例如药品、保健品、化妆品及生物燃料等。目前柠檬烯和红没药烯的工业生产主要是通过植物提取法实现的,但从植物组织中提取柠檬烯和红没药烯存在着产物含量低和分离纯化困难等缺点。微生物代谢工程的快速发展为这些植物天然产物的生产提供了一条更具潜力的生物合成路线。利用微生物代谢工程技术构建生产这些有价值的植物天然产物的微生物细胞工厂具有绿色清洁、可持续发展和经济效益好等独特优势。文中系统综述了近年来代谢工程技术在微生物合成柠檬烯和红没药烯过程中的应用进展,包括所涉及的宿主菌株、关键酶、代谢途径及...
zh-cn
pair_29380567
Aphids are major agricultural pests that cause significant yield losses of crops each year. (E)-β-farnesene (EβF), as the main component of the aphid alarm pheromones, can interrupt aphid feeding and cause other conspecies in the vicinity to become agitated or disperse from their host plant. Furthermore, EβF can functi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
蚜虫是重要的农业害虫,每年造成数以亿计的经济损失。[反]-β-法尼烯 [(E)-β-farnesene,EβF] 是绝大多数蚜虫报警信息素的主要成分,可使蚜虫产生骚动、从植株上脱落,并吸引蚜虫天敌,有效控制蚜虫危害。EβF合成酶是催化合成EβF 的关键酶,目前该基因已从薄荷、香橙、花旗松、黄花蒿、洋甘菊等植物中得到分离鉴定。植物中表达EβF 合成酶基因以催化法呢基焦磷酸 (Farnesyl diphosphate,FPP) 合成EβF 是控制蚜虫危害的重要策略。文中概括了当前植物抗蚜转基因研究现状,综述了植物EβF 合成酶基因及其在植物抗蚜分子育种中的应用。针对当前转基因植物的EβF 生成量较低等问题,展望了EβF 合成酶基因在植物...
zh-cn
pair_29380572
Xylanase is a high-profile glycoside hydrolase with applications in brewing, feed, pharmacy and bioenergy industries, but most of xylanases are in active below 30 ℃. In order to obtain low temperature active xylanase, a xylanase gene, XYN11A, was cloned from Penicillium sp. L1 and expressed in Pichia pastoris GS115. Af...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
木聚糖酶是一种备受关注的糖苷水解酶,能够应用于酿造、饲料、制药、生物能源等多个领域,但是目前大部分木聚糖酶在低于30 ℃的环境中活力较低。为了获得在较低温度下具有高活力的木聚糖酶,从青霉L1 (Penicillium sp. L1) 中克隆到一条GH11 木聚糖酶基因XYN11A,并在毕赤酵母GS115 中进行异源表达。经过纯化和酶学性质测定,该酶的最适pH 和最适温度分别为3.5−4.0 和55 ℃,能够在酸性和中性缓冲液 (pH 1.0−7.0) 中以及40 ℃下保持稳定,同时对所有已测试的金属离子和化合物都有一定的抗性。值得注意的是,该酶具有GH11 家族中比较高的比活力6 700 U/mg,另外,该酶在较低温度20−40 ℃...
zh-cn
pair_29380573
The head of the silkworm is a nerve center and a sense organ, contains antennaes and sensory hair, feels the outside signal, and responds to the external signal delivered to the brain. Juvenile hormone is mainly synthesized and secreted by corpora allata, and it needs to be played with the aid of the hormone binding pr...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
家蚕头部是一个神经中枢和感受的器官,其头部含有触角和感觉毛,感受外界的信号,并将外界信号传送到大脑进行反应。保幼激素主要是由咽侧体合成和分泌的,而保幼激素结合蛋白是保幼激素转运和发挥功能的载体,在昆虫体内具有极其重要的功能。文中通过SilkDB 和NCBI 数据库筛选并鉴定到一个新的具有保幼激素结合蛋白家族保守结构的蛋白BmTOL,其编码基因编号为BGIBMGA003404 (GenBank 登录号:KY681053)。利用原核表达系统成功表达了该蛋白,通过Ni-NTA 亲和层析的方法获得了BmTOL 的重组蛋白并制备了多克隆抗体。组织表达分析发现无论是转录水平还是蛋白水平BmTOL 在头部都是高量表达,且Bmtol 基因在起蚕时表...
zh-cn
pair_29380574
Cyclophilin A (CypA) is a member of peptidyl prolylisomerases (PPIase) family. CypA is best known as a ubiquitously distributed intracellular protein. It has also been shown to be secreted by cells in response to inflammatory stimuli and oxidative stress. Extracellular CypA (eCypA) interacts with CD147 to initiate infl...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
亲环素A(Cyclophilin A,CypA)是肽基脯氨酰顺/反异构酶家族成员,主要分布于细胞质中,当细胞受到外界刺激时会分泌到细胞间隙,与CD147 以配体-受体形式结合,促进炎症细胞的趋化。利用大肠杆菌BL21表达并纯化CypA 蛋白,利用该蛋白刺激小鼠的骨髓来源巨噬细胞(BMDM)。实时荧光定量PCR 和ELISA 试验结果发现,BMDM 分泌的IL-1β 等炎症因子的表达水平均显著上调,表明胞外CypA 具有促进炎症发生的作用。同时以CypA 蛋白为免疫原制备多克隆抗体,用于LPS 诱导的小鼠急性肺炎的治疗试验。与未治疗组相比,anti-CypA 抗体治疗组小鼠的肺组织表面出血点较少,损伤程度减轻,肺组织和血液中IL-1β...
zh-cn
pair_29380575
To prepare polyclonal antibodies (PcAb) against UspA1 of Moraxella catarrhalis (Mc), we used bioinformatic analysis to determine the surface exposed region in this protein that holds the antigen epitopes. Then the corresponding coding sequences for this fragment was artificially synthesized according to the codon usage...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
为制备抗卡他莫拉菌 (Moraxella catarrhalis,Mc)表面蛋白UspA1 胞外结构域的多克隆抗体 (PcAb),对UspA1 蛋白进行生物信息学分析,获取胞外结构域中抗原表位最为丰富的肽段,找到其对应的基因序列并引入大肠杆菌偏好性密码子,对其优化后化学合成全基因序列。将该基因序列按常规方法克隆入表达载体pET-28a(+)后表达重组UspA1-His 融合蛋白并纯化。以该纯化抗原免疫新西兰大白兔,经4 次免疫后,用Protein A 亲和层析柱从抗血清中纯化出抗UspA1-His 融合蛋白PcAb IgG。经免疫荧光法、酶联免疫吸附法及Western blotting 鉴定,抗UspA1-His 融合蛋白PcAb ...
zh-cn
pair_29380576
CD36, the major scavenger receptor, is intimately involved in the uptake of oxLDL in macrophages. To further study the function of CD36 in macrophages, we constructed CD36 gene silence cell lines (J774A.1) by lentivirus-mediated RNA interference technique, and analyzed the effect of CD36 in caveolin-1 protein expressio...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
CD36 作为重要的清道夫受体密切参与了巨噬细胞对氧化低密度脂蛋白的摄取作用,为了进一步研究CD36 的功能,本文利用慢病毒介导的shRNA 干扰技术,构建了CD36 基因沉默巨噬细胞 (J774A.1) 株,并以此为模型分析了CD36 在caveolin-1 蛋白表达过程中的作用。首先,针对CD36 基因序列设计合成5 条shRNA 片段,并构建得到pLKO.1-CD36-shRNA 慢病毒干扰载体,测序鉴定后与psiCHECK-Ⅱ-CD36 载体共转染入293T 细胞中,筛选出有效的CD36-shRNA。将慢病毒干扰载体与病毒包装质粒共转染入293T 细胞,包装得到慢病毒颗粒,之后感染J774A.1 细胞,经嘌呤霉素筛选后得到C...
zh-cn
pair_29380577
In this study, the mobilomes of nine teleost species were annotated by bioinformatics methods. Both of the mobilome size and constitute displayed a significant difference in 9 species of teleost fishes. The species of mobilome content ranking from high to low were zebrafish, medaka, tilapia, coelacanth, platyfish, cod,...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
通过生物信息学手段对9 种硬骨鱼转座组进行注释。结果表明9 种硬骨鱼类转座组大小和构成差异显著,其转座组含量从高到低分别为斑马鱼、矛尾鱼、青鳉鱼、罗非鱼、花斑剑尾鱼、大西洋鳕鱼、三刺鱼、金娃娃和红鳍东方鲀,转座子含量和基因组大小呈正相关。DNA 转座子在硬骨鱼类中具有多样性高和含量差异大的特点(0.50%–38.37%),是硬骨鱼类转座组差异的主要决定因素,其中hAT 和Tc/Mariner 超家族是硬骨鱼类主要的DNA转座子。RNA 转座子在硬骨鱼类中也具有多样性高的特点,其中LINE 转座子占硬骨鱼类基因组的0.53%–5.75%,共检测到14 个超家族分布,其中L1、L2、RTE 和Rex 转座子扩增较为明显,LTR 转座子除...
zh-cn
pair_29380578
Antibacterial peptide can be easily degraded by protease and has the lethal effect on the host Escherichia coli. In order to solve these problems and further improve the expression ability of the Escherichia coli system, the antimicrobial peptide Spinosan-C of Paa spinosa was studied. First, the codon of Spinosan-C was...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
为克服抗菌肽易被蛋白酶降解及对宿主大肠杆菌的杀伤作用,并进一步提高大肠杆菌系统的表达能力,以棘胸蛙Paa spinosa 抗菌肽Spinosan-C 为研究对象,按照大肠杆菌密码子利用频率进行密码子优化,设计合成8 拷贝的串联8×Spinosan-C 基因,将合成的串联基因克隆到大肠杆菌表达载体pET-28a,利用大肠杆菌感受态细胞Rosetta 进行原核表达,获得高效表达的串联8×Spinosan-C 重组蛋白,用甲酸专一性切割得到抗菌肽Spinosan-C单体。体外抑菌试验表明,切割后的抗菌肽Spinosan-C 单体对测试菌生长具有抑制作用,为蛙类抗菌肽的规模化制备提供了参考。.
zh-cn
pair_29380579
The effect of methanol addition on the heterologous expression of isoprenyl transferase NovQ was studied in Pichia pastoris Gpn12, with menadione and isopentenol as precursors to catalyze vitamin K2 (MK-3) synthesis. The expression of NovQ increased by 36% when 2% methanol was added every 24 h. The influence of initial...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
对异戊烯基转移酶NovQ 在毕赤酵母Gpn12 异源表达过程中诱导剂甲醇添加量进行了探究,并以毕赤酵母Gpn12 全细胞为酶源,以甲萘醌、异戊烯醇为前体,催化合成维生素K2 (MK-3)。每24 h 添加2%甲醇时,NovQ表达量提高约36%。考察摇瓶中初始pH、温度、甲醇添加量、前体 (甲萘醌、异戊烯醇) 添加量、催化时间、十六烷基三甲基溴化铵 (CTAB) 添加量等7 个因素对Gpn12 全细胞催化合成MK-3 的影响,发现催化温度、甲萘醌添加量、催化时间影响显著,对3 个显著因素进行响应面优化得出催化条件为:催化温度31.56 ℃,甲萘醌添加量295.54 mg/L,催化时间15.87 h,优化后的摇瓶MK-3 产量达到98....
zh-cn
pair_32959559
Through an analysis of the historical development of the concept of extra ordinary point, it is found that the terms of 'Qi point' 'extra ordinary point' 'Loujing point' 'extra meridian point' and 'Bie point' used in the ancient medical books in the Yuan, Ming, and Qing Dynasties actually expressed two different concep...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
通过对经外奇穴概念的历史发展脉络进行梳理,发现元、明、清古医籍中所用“奇穴”“经外奇穴”“漏经穴”“经外穴”“别穴”等名词术语,实际表达了“经穴之外奇效之穴”和“经穴之外腧穴”这两种不同的概念。前者应以“经外奇穴”为规范术语,以“奇穴”为简称;后者则应以“经外穴”为规范术语,以“漏经穴”“别穴”为别名。现代针灸学教材由于没能澄清这两种不同的概念,特别是对“经外奇穴”之“经外”的误读,在“经外奇穴”“经外穴”的定义上不能形成共识,因而在规范术语的厘定上一直徘徊不定,从早期的“经外奇穴”到中期的“奇穴”“经外穴”,近期又回到“经外奇穴”。教材中这些术语的混淆又直接影响了针灸术语国家标准和国际标准相关术语的厘定。.
zh-cn
pair_32959561
Chronic hypertension evoked aberrant myocardial remodeling is the main reason for progressive death from heart failure. It is of great clinical significance to find effective prevention and treatment methods to block this pathological process. It has been shown that imbalance of the autonomic nervous system (ANS) induc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
慢性高血压状态可引起自主神经功能失衡,主要表现为交感活动增强,副交感(迷走)活动受到抑制,从而激活由免疫细胞介导的炎性反应,加剧心肌组织的病理性重构。而迷走神经激活除具有负性心力作用外,还可发挥胆碱能抗炎效应,电针可通过激活迷走神经发挥降压和系统性抗炎效应。电针可延缓高血压—心肌肥厚的病理进程,而胆碱能抗炎通路在电针缓解慢性高血压—心肌重构病理进程中的作用犹未可知。本文通过系统梳理自主神经功能与高血压—心肌重构发生发展机制之间的联系,以及针刺对胆碱能抗炎通路中关键信号分子的调节作用,提出胆碱能抗炎通路参与介导针刺延缓高血压—心肌重构病理进程相关机制研究的新思路。.
zh-cn
pair_32959562
As a characteristic therapy in traditional Chinese medicine, acupuncture has shown potential advantages in anti-tumor therapy, and one of the therapeutic effects of acupuncture is to improve the immunosuppressive conditions in patients with tumor. Based on the immunoregulatory effect of acupuncture, this article summar...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
针灸作为中医特色疗法,在抗肿瘤治疗中已显示出潜在优势。其中,针灸的治疗作用之一体现在改善肿瘤患者免疫抑制状态。本文基于针灸免疫调节作用,从刺激自然杀伤细胞(NK)的活化、增加CD8+T细胞数量、调节辅助性T细胞1(Th1)与辅助性T细胞2(Th2)、调节性T细胞(Treg)与辅助性T细胞17(Th17)的平衡等方面总结针灸调节肿瘤免疫状态的效应机制。现有证据表明针灸能够通过多种靶点调节机体免疫抑制状态,但对肿瘤免疫微环境的调节作用及机制,亟需临床和基础研究进一步阐明。.
zh-cn
pair_32959563
Gastrointestinal motility dysfunction is not only a pathogenic factor but also a pathological manifestation. The authors summarize the recent studies on the mechanism of acupuncture and moxibustion in regulating gastrointestinal motility and analyze the effect of acupuncture and moxibustion on the brain-vagus-enteric n...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
胃肠动力功能异常既是发病因素,又是病理表现。笔者对近年针灸调节胃肠动力机制的相关研究进行分析与总结,发现针灸通过对脑-迷走神经-肠神经系统、Cajal间质细胞、胃肠肽、胃肠平滑肌及信号通路的调节改善胃肠动力。围绕胃肠动力功能,未来应开展针灸调节胃肠动力防治疾病的研究、腧穴特异性的研究、针灸双向调节的研究;针对针灸对肠道微生物群、肠神经元兴奋性影响因素的调控,开展研究探索针灸调节胃肠动力功能的潜在机制,以期为今后的研究提供参考与借鉴。.
zh-cn
pair_32959592
Under the guidance of the theory and technique of arrival of <i>qi</i> of heat-sensitive moxibustion, the technical elements of umbilical refining of moxibustion proposed in <i>The Guide to Medicine</i> by <i>LI Yan</i> were analyzed. It is believed that the parameters of moxibustion temperature and time are the key po...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在热敏灸得气理论与技术的指导下,解析李梴《医学入门》中炼脐灸法的技术要素,认为灸温与灸时参数是关键,并建立“量化艾绒、定量加绒”的标准以达到适宜灸温与灸时,创立热敏灸炼脐术,再现了李梴炼脐灸法“一身烘热、一身微汗、一身轻松”的神奇效应。热敏灸炼脐术临床多用于胃脘痛、泄泻、便秘、痛经、阳痿等病证的治疗,疗效显著。.
zh-cn
pair_32959601
The application of special acupoints for different primary symptoms of chronic gastritis in ancient literature of acupuncture and moxibustion was analyzed and summarized. With keywords, electronic and manual retrieval of ancient literature being performed to establish a database, the association rules were performed wi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
分析针灸古代文献中关于慢性胃炎的不同主症的特定穴运用特点,并探讨总结其规律。确定主题词,通过电子检索及手动检索相关古籍以建立数据库,采用SPSS Modeler 18.0对数据进行关联分析。结果表明: ①纳入条文2243条,含特定穴(除外仅为交会穴者)共109个,特定穴使用频次2554次(占71.7%),以足太阴脾经、足阳明胃经、任脉特定穴最多见,五输穴使用频次最高,其次为募穴。②“胃脘痛”“哕、呕、反胃”“嗳气、吐酸”“痞满”4类主症特定穴均常选取足三里、内关、中脘、公孙、太白,除“痞满”外其他主症还常取背俞穴,“嗳气、吐酸”还常配以章门穴,配伍上诸症均以内关-公孙的关联性最强,主症不同配伍有所侧重。.
zh-cn
pair_32963311
Ultrasound biomicroscopy (UBM) is the only available option for noninvasive, high-resolution imaging of the intricate iridociliary complex, and for anterior segment imaging with corneal haze or opacity. While these unique features render UBM essential for specific types of trauma, congenital anomalies, and anterior seg...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
摘要: 对于复杂的虹膜睫状体结构以及合并角膜混浊或不透明的眼前节进行非侵入性、高分辨率成像, 超声生物显微镜(UBM)是唯一选择。虽然这些特征使UBM对于特定类型的创伤、先天性畸形和眼前节肿瘤的诊断是必要的, 但人们已经在广泛的疾病谱中, 发现了UBM成像在结构评估中的临床用途。其不仅可用于眼内前节解剖, 也可用于眼睑和眼眶解剖的评估。在儿童群体中, 无论伴有角膜混浊或是云翳的眼前节疾病, 该成像工具都有非常特殊的地位。对于儿科患者的诊断, 医生会面临额外的挑战。儿童通常无法提供详细病史也无法全力配合相关检查, 因此对高分辨率成像的需求更大。本综述的目的是针对涉及应用UBM对儿童眼病进行描述、评估、诊断或优化治疗的文献进行筛选与整合...
zh-cn
pair_32965688
The goal of this study was to examine the effects of preterm birth and maternal childbirth-related posttraumatic stress and parenting stress on maternal mind-mindedness (MM). The study also investigated the effects of perceived social support on parenting stress and MM. Sixty-five preterm (N = 32) and full-term (N = 33...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
本研究旨在探讨早产、母亲分娩相关的创伤后压力和育儿压力对母亲心智 (MM) 的影响。本研究还调查了领悟社会支持对育儿压力和心智的影响。在6个月龄时观察了65个早产 (N = 32) 和足月 (N = 33) 的母婴二人组。从母婴互动的观察中获得了对母亲MM的测量。母亲们还通过在线调查提供了他们的PTSD症状, 育儿压力和领悟社会支持的等级。经历早产并不影响母亲在母婴互动过程中使用心理状态描述词。分娩相关的创伤后压力和育儿压力都不会直接影响母亲对孩子心理状态的恰当评价。但是, 在中等和较高的领悟社会支持水平下, 观察到育儿压力和心智之间呈负相关。在那些表现出较低或中等水平育儿压力的母亲中, 得到另一半情感支持的母性知觉会提高其心智, ...
zh-cn
pair_32965688
The goal of this study was to examine the effects of preterm birth and maternal childbirth-related posttraumatic stress and parenting stress on maternal mind-mindedness (MM). The study also investigated the effects of perceived social support on parenting stress and MM. Sixty-five preterm (N = 32) and full-term (N = 33...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Le but de cette étude était d'examiner les effets du stress posttraumatique lié à la naissance avant terme et à l'accouchement maternel et le stress de parentage sur l'Etat d'esprit/Orientation mentale (abrégé ici EE/OM). L’étude s'est aussi penchée sur les effets du soutien social perçu du stress de parentage et de l'...
fr
pair_32965688
The goal of this study was to examine the effects of preterm birth and maternal childbirth-related posttraumatic stress and parenting stress on maternal mind-mindedness (MM). The study also investigated the effects of perceived social support on parenting stress and MM. Sixty-five preterm (N = 32) and full-term (N = 33...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Ziel dieser Studie war es, die Effekte von Frühgeburten, geburtsbedingtem mütterlichen posttraumatischem Stress und elterlichem Stress auf mütterliche Mind-Mindedness (MM) zu untersuchen. Außerdem untersuchte die Studie den Effekt von wahrgenommener sozialer Unterstützung auf elterlichen Stress und MM. 65 Mutter-Kind D...
de
pair_32965688
The goal of this study was to examine the effects of preterm birth and maternal childbirth-related posttraumatic stress and parenting stress on maternal mind-mindedness (MM). The study also investigated the effects of perceived social support on parenting stress and MM. Sixty-five preterm (N = 32) and full-term (N = 33...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
El propósito de este estudio fue examinar los efectos del nacimiento prematuro y el estrés materno postraumático relacionado con dar a luz, y el estrés de la crianza sobre la disposición de la mente (MM). El estudio también investigó los efectos que la percepción del apoyo social tiene en el estrés de la crianza y la d...
es
pair_32969049
Tidal flats are a globally distributed coastal ecosystem important for supporting biodiversity and ecosystem services. Local to continental-scale studies have documented rapid loss of tidal habitat driven by human impacts, but assessments of progress in their conservation are lacking. With an internally consistent esti...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
滩涂是分布在全球的海岸带生态系统, 对支持生物多样性和生态系统服务十分重要。从局部到大陆尺度的研究报道了人类影响导致滩涂栖息地的快速丧失, 但是对它们保护进展的评估还较为有限。本研究基于目前全球滩涂已有的 Landsat 卫星图像, 获得对分布和变化内部一致的估计, 进而分析了保护区中滩涂的代表情况及人类对滩涂的压力。我们通过将滩涂分布图和全球保护区数据库进行空间叠加, 确定了保护区中滩涂的代表情况及其净变化。同样地, 我们将最近的滩涂分布图 (2014-2016年) 与人类改造地图 (human modification map, HM<sub>c</sub> , 无人类压力为 0, 非常高的人类压力为1) 相叠加, 以估计人类对...
zh-cn
pair_32969049
Tidal flats are a globally distributed coastal ecosystem important for supporting biodiversity and ecosystem services. Local to continental-scale studies have documented rapid loss of tidal habitat driven by human impacts, but assessments of progress in their conservation are lacking. With an internally consistent esti...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Cobertura Mundial de Áreas Protegidas y la Presión Humana sobre las Planicies Mareales Resumen Las planicies mareales son un ecosistema costero con distribución global e importancia para el mantenimiento de la biodiversidad y los servicios ambientales. Existen estudios, desde locales hasta continentales, que han docume...
es
pair_32969092
To compare morning and evening salivary melatonin levels, sleep quality and chronotype between nurses working fixed day shifts and those working rotating night shifts. Rotating night shift work is an inevitable part of nursing and is a major reason for disrupted sleep. Cross-sectional comparative design. We used cluste...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 比较固定白班和轮值夜班护士的早晚唾液褪黑素水平、睡眠质量和作息类型。 背景: 轮值夜班工作是护理工作中不可避免的,也是影响睡眠的一个重要原因。 设计: 横截面对比研究。 受试者和环境: 我们采用整群抽样方式,在阿联酋招募了520名固定日班和轮值夜班的女护士。 方法: 从相应的唾液样本中测量早晚褪黑素。睡眠质量评估用匹兹堡睡眠质量指数和首选昼夜时间自我评估用于评估受试者的作息类型。数据收集时间为2017年10月至2018年12月。 结果: 与固定白班护士相比,轮值夜班护士的晚间褪黑素显著降低。尽管轮值夜班组受试者(N=110,42.31%)比固定日班组受试者(N=90,36.00)的睡眠质量更好,但组间睡眠质量没有显著差异。与...
zh-cn
pair_32970338
Constructionist approaches in the field of systemic family therapy prioritize reflexivity to promote personal development within training, often leaning on group processes. Drawing from a qualitative study we conducted to address the lack of related research, we present how systemic family therapy trainees experience r...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
系统家庭治疗领域的建构主义方法优先考虑反身性来促进训练过程中的个人发展,通常依赖于团体过程。针对解决相关研究比较匮乏的问题,我们进行了一项质的研究,并从该研究中总结出系统性家庭治疗学员是如何通过群体过程体验反身性方面的发展的。10名系统的家庭治疗学员参与了半结构式访谈,并对其进行了解释现象学分析。这里的分析报告了三个超级主题: 通过挑战和奖励发展自反性,在训练小组内创造有条件的自反性空间,通过群体的自反性过程经历身份的动态变化发展。我们的研究结果表明,受训者经历的反身性发展是一个复杂的、和个人发展相关的过程,这突出了训练组的关键作用,尽管它依赖于某些先决条件。本研究强调在心理治疗训练中,推进探索团体过程对反身性发展的潜力非常有必要。...
zh-cn
pair_32970338
Constructionist approaches in the field of systemic family therapy prioritize reflexivity to promote personal development within training, often leaning on group processes. Drawing from a qualitative study we conducted to address the lack of related research, we present how systemic family therapy trainees experience r...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Lo enfoques construccionistas en el ámbito de la terapia familiar sistémica priorizan la reflexividad para promover el desarrollo personal dentro de la capacitación, generalmente apoyándose en procesos grupales. Valiéndonos de un estudio cualitativo que realizamos para abordar la falta de investigaciones relacionadas, ...
es
pair_32972062
Shock is one of the major complications and causes of death in the early stage of burns. Although burn shock is an old problem, its clinical treatment is often not timely nor standardized, resulting in the shock to pass unsteadily or even be difficult to correct, leading to early infection and organ complications. To s...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
休克是烧伤早期主要并发症和死亡原因之一。虽然烧伤休克是一个老问题,但其临床治疗常不及时、不规范,致使休克期度过不平稳甚至休克难以纠正,导致早期感染和脏器并发症。为规范烧伤休克防治,专家组从主要病理生理、临床表现与诊断、防治、监测以及有关注意事项等方面讨论形成了本共识,作为烧伤休克防治的参考,具体应用时应根据患者实际情况而定。.
zh-cn
pair_32972063
This article is based on the spirit of the National Postgraduate Education Conference that has just been held. The newly added interdisciplinary subjects will bring new opportunities to the construction of burns and wound repair disciplines. This article discusses the intersecting progress of wound repair and the relat...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
本文基于刚召开的全国研究生教育会议精神,新增的交叉学科将为烧伤和创面修复学科建设带来新的机遇,由此探讨了创面修复与相关领域交叉进展,引出关于'创面修复基础研究可以关注哪些基础科学问题'和'如何借鉴其他学科领域进展解决创面修复科学问题'等思考和建议,旨在把握机遇,利用学科交叉进一步拓展和深入开展创面修复基础研究,促进学科发展。.
zh-cn
pair_32972064
In recent years, the incidence of chronic wound has been on the rise. This disease has a high rate of disability and is difficult to treat, therefore its prevention and treatment needs the attention of modern medicine. After decades of development, although advances have been made in the treatment of chronic wounds, ma...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
近年来,慢性创面发生率呈上升趋势,该病致残率高、治疗难度大,其预防和治疗应当得到现代医学的重视。经过几十年的发展,慢性创面的治疗尽管已取得诸多进展,但仍存在许多问题,要实现慢性创面的快速修复还有很长的路要走。本文总结了慢性创面的定义及治疗的理论基础、创面敷料及治疗技术的应用,旨在与业内同仁们探讨慢性创面治疗的理论和策略。.
zh-cn
pair_32972074
From September 2013 to October 2018, 39 patients (28 males and 11 females, aged 21 to 76 years) with stage 4 pressure ulcers were admitted to the General Hospital of Xinjiang Military Command. The area of pressure ulcers ranged from 2 cm×2 cm to 20 cm×12 cm on admission. The two-stage method of debridement and skin fla...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
2013年9月—2018年10月,新疆军区总医院收治39例4期压疮患者,其中男28例、女11例,年龄21~76岁。入院时创面面积2 cm×2 cm~20 cm×12 cm,均采用清创联合皮瓣转移'两步法'修复压疮创面。第1步,创面彻底清创(清创次数1次26例、2次10例、3次3例);6~12 d后行第2步皮瓣转移术(局部皮瓣16例、带血管蒂的岛状皮瓣8例、筋膜皮瓣5例、臀大肌肌皮瓣5例、股二头肌肌皮瓣5例),皮瓣面积4 cm×2 cm~16 cm×10 cm,部分供区直接拉拢缝合,无法缝合的切取大腿外侧中厚皮片覆盖。本组患者压疮创面均愈合,且无窦道形成。随访6个月~5年,原手术部位无压疮复发,皮瓣质地柔软、外形较佳。清创联合皮瓣转移...
zh-cn
pair_32972075
On January 10, 2018, a 35-year-old male patient with a 3 day stingray stinger injury in his left thigh was admitted to Xuzhou Central Hospital. At the time of admission, the patient's left thigh was red, swollen, and painful. On the day of admission, the patient underwent emergency operation in the outpatient operating...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
2018年1月10日徐州市中心医院收治1例魟鱼刺伤左大腿3 d的35岁男性患者。入院时患者左大腿红肿、疼痛明显,入院当天即在门诊手术室急诊行局部清创,去除感染坏死组织。常规换药创面好转后行手术清创、负压伤口疗法,最终采用局部皮瓣修复创面。皮瓣修复术后14 d患者拆线出院。随访半年,患者术区恢复良好。本病例提示魟鱼刺伤后及时正确的院前处理、入院后及时彻底清创、全身抗生素应用是减少毒素进一步损害重要手段,负压伤口疗法完善'创面床'准备后采用局部皮瓣移植方式修复创面可达到较佳效果。.
zh-cn
pair_32972076
On April 11, 2019, a 36-year-old female patient was admitted to Hunan Cancer Hospital. Five years after the modified radical mastectomy for right breast cancer, she planned to undergo scar releasing and reconstruction of right chest wall and free deep inferior epigastric artery perforator (DIEP) flap transfer, right br...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
2019年4月11日,湖南省肿瘤医院收治1例36岁女性患者。接受右侧乳腺癌改良根治术后5年,患者入院后计划行右侧胸壁瘢痕整复+游离腹壁下动脉穿支(DIEP)皮瓣移植+右侧乳房再造+左侧乳房上提术。右侧胸壁瘢痕切除后创面面积为18 cm×10 cm,术中误伤DIEP血管蒂,转而设计左侧大腿内侧股深动脉穿支(PAP)皮瓣,皮瓣面积为20 cm×11 cm、厚4.5 cm、穿支血管蒂长度为7.6 cm,皮瓣质量为360 g。转移皮瓣修复右侧乳房缺损并填塞深部腔隙,PAP血管蒂与右侧胸廓内血管近端吻合。术中见皮瓣血运良好,同期完成左侧乳房上提术,大腿及腹部皮瓣供区直接拉拢闭合。术后皮瓣存活良好,供区愈合良好。术后随访7个月,大腿供区外观功能...
zh-cn
pair_32972077
In November 4, 2016, a 1 year and 3 months old male patient with face and neck scald complicated with severe scald of oropharynx was admitted to Guangzhou Red Cross Hospital 1 hour after injury. The child developed upper respiratory tract obstruction 2 hours after injury, therefore tracheotomy and intubation were perfo...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
2016年11月4日,广州市红十字会医院收治1例伤后1 h入院的面颈部烫伤合并口咽部严重烫伤的1岁3个月男性患儿。伤后2 h患儿即出现上呼吸道梗阻表现,立即予以气管切开置管建立人工气道,并予以抗感染、补液、换药等对症治疗。伤后第10天,患儿拔管前试堵管过程中出现呼吸困难,难以拔管,继续予以呼吸机辅助通气、加强抗感染等对症治疗。伤后第17天予以调整拔管方案,拔管前30 min肌内注射苯巴比妥镇静、应用阿托品减少气道分泌物,之后拔管成功。经过21 d治疗,患儿痊愈出院。本病例强调了拔管困难的原因中儿童精神因素的重要影响,为临床处理儿童气管切开术后拔除气管套管提供了参考。.
zh-cn
pair_32972078
Angiogenesis is the core step of wound repair, and vascular endothelial progenitor cells (EPC) play an extremely important role during wound repair. Recent studies have shown that vascular EPC-derived exosomes (EPC-Exo) can protect vessels, promote the proliferation and migration of vascular endothelial cells, and have...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
血管新生是创面修复的核心步骤,血管内皮祖细胞(EPC)在其中发挥着极其重要的作用。新近研究显示,血管EPC源性外泌体(EPC-Exo)能保护血管,促进血管内皮细胞增殖、迁移及对血管内皮细胞具有抗炎、抗氧化及抗凋亡等作用。本文就近年来血管EPC-Exo在血管新生的作用机制及创面修复领域的潜在应用研究方面进行综述。.
zh-cn
pair_32974923
Relationship distress and divorce are major risk factors for the development or exacerbation of psychopathology and psychosocial impairments. Given that heightened negative emotions within couples' interactions may portend negative relationship outcomes, it is critical to understand how emotions unfold across a convers...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
关系紧张和离婚是精神病理和社会心理障碍发展或恶化的主要风险因素。考虑到在伴侣互动中强烈的负面情绪可能预示着负面的关系结果,了解情绪是如何在对话中展开,以及伴侣是如何影响彼此的即时情绪体验至关重要。这项研究检验了在一次互动中这些调节动力是否能同时预测25年后的关系满意度。在25对伴侣谈论感情问题时,我们测量了声音编码的情绪唤起(f0)。通过不同的分析策略,结果表明一方的f0动态与另一方的满意度有直接和长期的联系。如果另一方(a)整体表现出更高的f0,以及(b)在谈话中不断升级f0,那么另一方的满意度就会降低。然而,当谈话中他们的f0升级时,双方会更满意。而且,如果f0在恢复到情绪基线之前保持更长时间的升高,女性会更满意。因此,f0越高...
zh-cn
pair_32974923
Relationship distress and divorce are major risk factors for the development or exacerbation of psychopathology and psychosocial impairments. Given that heightened negative emotions within couples' interactions may portend negative relationship outcomes, it is critical to understand how emotions unfold across a convers...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
El distrés relacional y el divorcio son grandes factores de riesgo para el desarrollo o la exacerbación de alteraciones psicopatológicas y psicosociales. Teniendo en cuenta que las emociones negativas intensificadas dentro de las interacciones de las parejas pueden predecir consecuencias negativas en las relaciones, es...
es
pair_32975336
Habitat loss and fragmentation can negatively influence population persistence and biodiversity, but the effects can be mitigated if species successfully disperse between isolated habitat patches. Network models are the primary tool for quantifying landscape connectivity, yet in practice, an overly simplistic view of s...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
生境丧失和破碎化会对种群续存和生物多样性产生负面影响, 但如果物种成功扩散到孤立的栖息地斑块, 则可以缓解这种影响。网络模型是量化景观连接度的主要工具, 但在实际应用中, 物种扩散往往被过度简化。这些模型通常假设所有个体以相同的概率移动相同的固定距离, 而忽略了个体扩散能力的变异。本研究开发了一种建模方法来解决这个问题。我们在网络模型中加入了个体扩散函数, 以确定个体扩散能力差异如何改变对景观尺度连接度的理解, 并把我们的方法应用在明尼苏达州的一个破碎化的草原景观中。结果显示, 忽略个体扩散的变异会导致高估种群产生局部灭绝的稳健性, 且低估种群应对局部栖息地丧失能力的稳健性。此外, 简化扩散模型还会低估小种群栖息地亚结构的数量, 并...
zh-cn
pair_32975336
Habitat loss and fragmentation can negatively influence population persistence and biodiversity, but the effects can be mitigated if species successfully disperse between isolated habitat patches. Network models are the primary tool for quantifying landscape connectivity, yet in practice, an overly simplistic view of s...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Consecuencias de la Omisión de la Variación en la Dispersión en los Modelos de Redes para la Conectividad de Paisajes Resumen La pérdida y la fragmentación del hábitat pueden influir negativamente la persistencia de poblaciones y biodiversidad. Sin embargo, estos efectos pueden ser mitigados si las especies tienen una ...
es
pair_32975354
It has been demonstrated recently that immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) is present in the serum of allergen-sensitized dogs and cats, and that these CCD-specific antibodies might confound serological testing. The objective was to document the prevalence of CCD detectable ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景: 最近已经证明,交叉反应性碳水化合物决定簇(CCD)特异性免疫球蛋白(Ig)E存在于过敏原致敏犬和猫的血清中,并且这些CCD特异性抗体可能混淆血清学检测。 假设/目的: 目的是记录在基于单克隆鸡尾酒的酶联免疫吸附试验中可检测到CCD的概率,该试验设计用于检测犬和猫血清中的过敏原特异性IgE,并定义成功抑制这些CCD的方法。 方法和材料: 100份犬血清样本,在用RIDA-CCD和含源自菠萝蛋白酶的碳水化合物的专有抑制剂(BROM-CCD)抑制前后,评价了对菠萝蛋白酶和市售碳水化合物特异性抗体抑制剂(RIDA-CCD)的反应性发生率。随后,使用含和不含BROM-CCD的血清稀释剂评价600只犬和600只猫的血清。 结果: RID...
zh-cn
pair_32975354
It has been demonstrated recently that immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) is present in the serum of allergen-sensitized dogs and cats, and that these CCD-specific antibodies might confound serological testing. The objective was to document the prevalence of CCD detectable ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Il a été démontré récemment que les immunoglobulines (Ig)E spécifiques des CCD (cross-reactive carbohydrate determinants) sont présents dans le serum des chiens et chats sensibilisés aux allergènes et que ces anticorps spécifiques-CDD peuvent perturber les tests sérologiques. HYPOTHÈSES/OBJECTIFS: L’objectif était de d...
fr
pair_32975354
It has been demonstrated recently that immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) is present in the serum of allergen-sensitized dogs and cats, and that these CCD-specific antibodies might confound serological testing. The objective was to document the prevalence of CCD detectable ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Es wurde kürzlich gezeigt, dass Immunglobulin (Ig)E spezifisch gegen kreuzreaktive Kohlenhydratdeterminanten (CCD) im Serum Allergen-sensibilisierter Hunde und Katzen vorkommt und dass diese CCD-spezifischen Antikörper die serologische Testung stören könnten. Das Ziel dieser Studie war es, die Prävalenz von CCD zu doku...
de
pair_32975354
It has been demonstrated recently that immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) is present in the serum of allergen-sensitized dogs and cats, and that these CCD-specific antibodies might confound serological testing. The objective was to document the prevalence of CCD detectable ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Demonstrou-se recentemente que a imunoglobulina (Ig) E específica para determinantes de carboidratos com reatividade cruzada (CCD) está presente no soro de cães e gatos sensibilizados com alérgenos, e que esses anticorpos específicos para CCD podem confundir os testes sorológicos. HIPÓTESE/OBJETIVO: O objetivo foi docu...
pt
pair_32975354
It has been demonstrated recently that immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) is present in the serum of allergen-sensitized dogs and cats, and that these CCD-specific antibodies might confound serological testing. The objective was to document the prevalence of CCD detectable ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
se ha demostrado recientemente que la inmunoglobulina (Ig) E específica para determinantes de carbohidratos de reacción cruzada (CCD) está presente en el suero de perros y gatos sensibilizados a alérgenos, y que estos anticuerpos específicos de CCD pueden confundir las pruebas serológicas. HIPÓTESIS/OBJETIVO: el objeti...
es
pair_32975729
Fibroblast activation protein (FAP) as a specific marker of activated fibroblasts can be visualized by positron emission tomography (PET) using Ga-68-FAP inhibitors (FAPI). Gallium-68-labeled FAPI is increasingly used in the staging of various cancers. In addition, the first cases of theranostic approaches have been re...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景 : 成纤维细胞活化蛋白(FAP)作为活化成纤维细胞的一种特异性标志物,可以通过Ga-68-FAP抑制剂(FAPI)的正电子发射断层扫描(PET)显像进行活体可视化。Ga-68标记的FAPI已被越来越多地用于各种癌症的分期。并且已有第一个诊疗一体化的病例报道。本文在接受Ga-68 FAPI PET进行肿瘤分期患者中研究了心肌FAPI摄取结果。 方法和结果 : 回顾性分析了Ga-68 FAPI PET检查癌症分期的心脏示踪剂摄取情况。摄取值(SUV)作为因变量,临床资料作为协变量,纳入单变量回归模型。 从2018年9月到2019年11月,共纳入32例在我院接受了FAPI PET检查的患者。其中6例患者(18.8%)表现为局灶性心肌...
zh-cn
pair_32975729
Fibroblast activation protein (FAP) as a specific marker of activated fibroblasts can be visualized by positron emission tomography (PET) using Ga-68-FAP inhibitors (FAPI). Gallium-68-labeled FAPI is increasingly used in the staging of various cancers. In addition, the first cases of theranostic approaches have been re...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La protéine d’activation des fibroblastes (FAP) activés et matures peut être visualisée par tomographie à émission de positons (TEP) à l’aide d’inhibiteurs de l’activation des fibroblastes (FAPI). FAPI marqué au gallium 68 est de plus en plus utilisé dans la stratification de divers cancers. De plus, les premiers exemp...
fr
pair_32975729
Fibroblast activation protein (FAP) as a specific marker of activated fibroblasts can be visualized by positron emission tomography (PET) using Ga-68-FAP inhibitors (FAPI). Gallium-68-labeled FAPI is increasingly used in the staging of various cancers. In addition, the first cases of theranostic approaches have been re...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Proteína de activación de fibroblastos (FAP) como marcador específico de fibroblastos maduros activados se puede visualizar mediante tomografía por emisión de positrones (PET) usando inhibidores de Ga-68-FAP (FAPI). El FAPI marcado con galio 68 se usa cada vez más en la estatificación de varios tipos de cáncer.Además, ...
es
pair_32978996
Knowledge and understanding about the impact of cumulative adverse experiences on the health and wellbeing of children, adolescents, and adults has rapidly expanded over the past 30 years. Despite the invaluable attention and support this proliferation has drawn to the importance of early childhood experiences, we beli...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在过去的30年里, 人们对累积的不良经历作用于儿童、青少年和成人的健康福祉影响的认识和理解迅速增加。尽管儿童早期经历的重要性受到了宝贵的关注和支持, 但我们认为, 现在是时候超越广义风险指标, 更具体和个性化地理解风险暴露与幼儿临床结果的关系。在婴儿心理健康方面, 需要更具体地将早期生活中的不良护理经历与儿童的精神病理学联系起来。我们强调区分创伤经历和剥夺经历的观点, 并以创伤后应激障碍和反应性依恋障碍为例, 来证明我们对早期不良护理的理解中, 更高的特异性可以为幼儿提供更准确、更有针对性的诊断和治疗。研究人员和临床医生都从一种方法中受益, 这种方法可以更深入地了解我们所服务的儿童其特定类型的经历和结果之间的联系。.
zh-cn
pair_32978996
Knowledge and understanding about the impact of cumulative adverse experiences on the health and wellbeing of children, adolescents, and adults has rapidly expanded over the past 30 years. Despite the invaluable attention and support this proliferation has drawn to the importance of early childhood experiences, we beli...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Les connaissances et la compréhension sur l'impact d'une accumulation d'expériences adverses sur la santé et le bien-être des enfants, des adolescents et des adultes se sont rapidement étendues au fil des 30 dernières années. En dépit de l'attention précieuse et du soutien de cette prolifération qui ont montré l'import...
fr
pair_32978996
Knowledge and understanding about the impact of cumulative adverse experiences on the health and wellbeing of children, adolescents, and adults has rapidly expanded over the past 30 years. Despite the invaluable attention and support this proliferation has drawn to the importance of early childhood experiences, we beli...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Widrige Bedingungen im frühen Leben: Die Unterscheidung zwischen Trauma und Deprivation bei kleinen Kindern Das Wissen um die Auswirkungen kumulativer widriger Erfahrungen auf die Gesundheit und das Wohlbefinden von Kindern, Jugendlichen und Erwachsenen hat in den letzten 30 Jahren rapide zugenommen. Trotz der unschätz...
de
pair_32978996
Knowledge and understanding about the impact of cumulative adverse experiences on the health and wellbeing of children, adolescents, and adults has rapidly expanded over the past 30 years. Despite the invaluable attention and support this proliferation has drawn to the importance of early childhood experiences, we beli...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
El conocimiento y la comprensión acerca del impacto de experiencias adversas acumuladas sobre la salud y bienestar de los niños, adolescentes y adultos se ha expandido rápidamente durante los pasados 30 años. A pesar de la inestimable atención y apoyo que esta proliferación ha derivado con respecto a la importancia de ...
es
pair_32979029
We have previously shown that serum testosterone was associated with impaired fasting glucose (IFG) and type 2 diabetes (T2D). Testosterone can be acting through binding the androgen receptor (AR). Therefore, we aimed to explore the independent associations of AR DNA methylation (ARm) with IFG and T2D and the moderatio...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
None
zh-cn
pair_32981035
The present study aimed to describe patterns of risk and protective factors affecting U.S. Army families and their association with mental health diagnoses among military-connected children. Wartime military service is associated with increased adverse outcomes for military-connected youth, but few studies have explore...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
本研究旨在描述影响美国军人家庭的风险模式和保护性因素,以及与部队相关联的青少年其心理健康诊断的相关性。战时服兵役与很多和部队相关联青少年其不良后果有所增加有关,但很少有研究探讨两者同时出现的风险和获得保护因素的影响。使用大数据方法连接现有的数据集,保护因素(如婚姻和家庭功能)是从1630名美国军人配偶完成的自愿调查中得出的。风险因素(如父母心理健康、家庭迁移、部署)取自美国国防部(DoD)档案数据。青少年的精神健康诊断率来自于国防部的医疗记录。采用分三步的潜在剖面分析方法,得到了5个具有不同风险和保护因素的剖面。最大的一组(40%的样本)有相当多的保护因素和有限的风险暴露。通过对不同的剖面观察分析得到,与部队相关联的年轻人其心理健康...
zh-cn
pair_32981035
The present study aimed to describe patterns of risk and protective factors affecting U.S. Army families and their association with mental health diagnoses among military-connected children. Wartime military service is associated with increased adverse outcomes for military-connected youth, but few studies have explore...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
el presente estudio tuvo como finalidad describir los patrones de riesgo y los factores protectores que afectan a las familias del Ejército de los Estados Unidos y su asociación con los diagnósticos de salud mental entre niños relacionados con los militares. El servicio militar en tiempos de guerra está asociado con ma...
es
pair_32981036
There is a well-established bidirectional, negative association between couple satisfaction and depressive symptoms. Yet, a family systems perspective emphasizes the role of the therapist in interrupting this recursive cycle between couple satisfaction and depressive symptoms. The current study utilized longitudinal da...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
伴侣满意度和抑郁症状之间存在一种明确的双向负相关关系。然而,家庭系统的观点强调治疗师的干预作用,因为治疗师可以打破伴侣满意度和抑郁症状之间的反复循环。本研究利用纵向数据来探索抑郁症状和伴侣满意度之间的双向联系,这种相关性受到治疗过程中建立起来的治疗联盟的调节影响。这项研究包括了108对在大学培训诊所接受伴侣治疗的伴侣。在接受治疗前和第四次治疗结束这两个时间点,伴侣们分别评估了他们的抑郁症状和夫妻满意度,在第二和第三次治疗结束时,他们也报告了他们与治疗师的个人治疗联盟。主导行为者-对象相互依赖调节模型分析揭示了几种调节效应。一般来说,在治疗联盟度较低的情况下,与初始症状较少的夫妻相比,初始症状较高的夫妻(如抑郁症状和伴侣满意度较低)在...
zh-cn