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pair_31379018
Culturomics is emerging as an important field within science, as a way to measure attitudes and beliefs and their dynamics across time and space via quantitative analysis of digitized data from literature, news, film, social media, and more. Sentiment analysis is a culturomics tool that, within the last decade, has pro...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
El Análisis de Opinión como Medida de la Cultura de Conservación en la Literatura Científica Lennox et al. Resumen La culturomía está emergiendo como un campo importante dentro de la ciencia pues es una manera de medir las actitudes, creencias y sus dinámicas a través del tiempo y el espacio por medio de un análisis cu...
es
pair_31381814
Culturally adapted evidence-based parenting interventions constitute a key strategy to reduce widespread mental health disparities experienced by Latinx populations throughout the United States. Most recently, the relevance of culturally adapted parenting interventions has become more prominent as vulnerable Latinx pop...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在美国拉丁族裔人口中, 文化调适后的以实证为基础的家长干预是一个非常重要的可以减少较为广泛的心理健康方面不均衡差异的关键策略。最近, 美国国内日益兴起的反移民社会大环境给脆弱的拉丁裔人口造成了各种巨大的外界压力。这种情况下文化调适后的家长干预其相关作用越来越显著。NIMH资助的较大规模调查研究旨在针对实证为基础的家长干预即GenerationPMTO<sup>©</sup> 的两个文化调适后版本的不同效果进行对比研究, 而本文的研究就是含括在该大型研究中的一部分。具体而言, 研究的对象是原籍为墨西哥的低收入移民家长, 让他们分别接触了GenerationPMTO的两种版本的一种。有的面向的是主要集中在家长培训部分的文化调适后版本, ...
zh-cn
pair_31381814
Culturally adapted evidence-based parenting interventions constitute a key strategy to reduce widespread mental health disparities experienced by Latinx populations throughout the United States. Most recently, the relevance of culturally adapted parenting interventions has become more prominent as vulnerable Latinx pop...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Las intervenciones basadas en evidencia, dirigidas a padres y adaptadas a la cultura son una estrategia clave para reducir las desigualdades en salud mental generalizadas que las poblaciones de latin@s experimentan en los Estados Unidos. Más recientemente, la relevancia de intervenciones dirigidas a padres adaptadas a ...
es
pair_31381844
The complexity of the African American community in the United States continues to evolve. The growing number of professional African Americans who grew up in the postcivil rights era combined with the persistent reminders of inequity paints a complex backdrop for understanding African American relationships. The major...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在美国,非洲裔美国人社区的复杂性不断在发展演化。在后民权运动时代成长起来的职业非裔美国人的数目不断在增加,与此同时长久的不平等仍然持续存在,这些都给理解非裔美国人的婚恋关系勾勒出了复杂的背景语境。我们关于非裔美国人伴侣的了解很大程度来自于非临床研究类的社会科学领域研究,如社会学和人口统计学等。而且,关于如何对待非裔美国人伴侣婚恋问题的学术方面的研究文献也相对匮乏。本文旨在对现存的有限的研究加以补充,为那些理解和治疗非裔美国人伴侣的临床从医者和学者提供一系列可供思考研讨的问题。具体而言,本研究提倡使用一个综合性模型,它可以非常好地应对治疗中面对的非裔美国伴侣的复杂性和那些敏感微妙的问题。因此,本文将讨论综合系统性治疗(IST)模型(P...
zh-cn
pair_31381844
The complexity of the African American community in the United States continues to evolve. The growing number of professional African Americans who grew up in the postcivil rights era combined with the persistent reminders of inequity paints a complex backdrop for understanding African American relationships. The major...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La complejidad de la comunidad afroamericana de los Estados Unidos continúa evolucionando. El número cada vez mayor de afroamericanos profesionales que crecieron en la era posterior a los derechos civiles combinado con los recordatorios constantes de inequidad pinta un telón de fondo complejo para comprender las relaci...
es
pair_31384072
To estimate of the number of children younger than 5 years who were household contacts of people with tuberculosis and were eligible for tuberculosis preventive treatment in 2017. To estimate the number of eligible children, we obtained national values for the number of notified cases of bacteriologically confirmed pul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
旨在估计 2017 年家人患有结核病且符合结核病预防治疗条件的 5 岁以下儿童人数。. 为了估计符合条件的儿童人数,我们从已出版的资料中获取了 2017 年通过细菌学方法确诊的结核病公示案例的全国性数据、2017 年 5 岁以下人口的比例和平均家庭规模数据。通过系统综述、荟萃分析和泊松回归模型,我们获得了全球数据,关于每个家庭活动性结核病病例的数量和家人感染结核病的 5 岁以下儿童感染潜伏性结核病的患病率。. 在 2017 年,全球符合结核病预防治疗的 5 岁以下儿童人数估计值为 127 万(95% 不确定区间,UI:1.24–1.31),这与全球儿童预防性治疗覆盖率最高为 23% 的估计值一致。从国家层面来看,估计值范围从冰岛、巴...
zh-cn
pair_31384072
To estimate of the number of children younger than 5 years who were household contacts of people with tuberculosis and were eligible for tuberculosis preventive treatment in 2017. To estimate the number of eligible children, we obtained national values for the number of notified cases of bacteriologically confirmed pul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Estimer le nombre d'enfants de moins de 5 ans qui étaient en contact avec des membres de la famille atteints de tuberculose et qui étaient éligibles à un traitement préventif de cette maladie en 2017. Pour estimer le nombre d'enfants éligibles, nous nous sommes procuré, à partir de diverses publications, les valeurs na...
fr
pair_31384072
To estimate of the number of children younger than 5 years who were household contacts of people with tuberculosis and were eligible for tuberculosis preventive treatment in 2017. To estimate the number of eligible children, we obtained national values for the number of notified cases of bacteriologically confirmed pul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Estimar el número de niños menores de cinco años que tuvieron contacto con personas con tuberculosis en sus hogares y que eran elegibles para el tratamiento preventivo de la tuberculosis en 2017. Para estimar el número de niños elegibles, se obtuvieron valores nacionales para el número de casos notificados de tuberculo...
es
pair_31384072
To estimate of the number of children younger than 5 years who were household contacts of people with tuberculosis and were eligible for tuberculosis preventive treatment in 2017. To estimate the number of eligible children, we obtained national values for the number of notified cases of bacteriologically confirmed pul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Оценка по состоянию на 2017 год количества детей младше пяти лет, проживающих в одной семье с больным туберкулезом и нуждающихся в профилактическом лечении. Для оценки количества детей, нуждающихся в лечении, авторы получили из опубликованных источников национальные показатели по состоянию на 2017 год о количестве пост...
ru
pair_31384074
In 2018, three independent reports were published, emphasizing the need for attention to, and improvements in, quality of care to achieve effective universal health coverage. A key aspect of high quality health care and health systems is that they are person-centred, a characteristic that is at the same time intrinsica...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
2018 年发表的 3 份独立报告强调了关注并改善护理质量的需求,以实现有效的全民健康覆盖。高质量的医疗保健和卫生系统的关键考量之一是以人为本,此特点的重要性不仅体现在本质层面上(所有人都有权得到有尊严的对待和尊重),还体现在应用层面上(以人为本的护理服务与提高医疗护理利用和改善健康效果息息相关)。在响应“2019 行动年”的号召后,我们就如何开展衡量以人为本的护理服务为政策制定者、研究人员和实施人员提供指导。理论上来说,以人为本的护理服务可衡量将使得我们可以就质量改善方面的工作进行评估,并且确保医疗体系对其服务对象负有责任。然而实际上,在以人为本不同层面设计和实施措施缺乏透明度和精准度,这限制了此类措施的实用性。针对以患者为中心的...
zh-cn
pair_31384074
In 2018, three independent reports were published, emphasizing the need for attention to, and improvements in, quality of care to achieve effective universal health coverage. A key aspect of high quality health care and health systems is that they are person-centred, a characteristic that is at the same time intrinsica...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
En 2018, la publication de trois rapports indépendants soulignait la nécessité de prêter attention à la qualité des soins et de l'améliorer pour parvenir à une réelle couverture sanitaire universelle. L'un des aspects clés de la qualité des soins et des systèmes de santé est qu'ils soient centrés sur la personne, carac...
fr
pair_31384074
In 2018, three independent reports were published, emphasizing the need for attention to, and improvements in, quality of care to achieve effective universal health coverage. A key aspect of high quality health care and health systems is that they are person-centred, a characteristic that is at the same time intrinsica...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Se publicaron tres informes independientes en 2018, en los que se hacía hincapié en la necesidad de prestar atención a la calidad de la atención sanitaria y de mejorarla para lograr una cobertura sanitaria universal eficaz. Un aspecto fundamental de la atención sanitaria y los sistemas de salud de alta calidad es que e...
es
pair_31384074
In 2018, three independent reports were published, emphasizing the need for attention to, and improvements in, quality of care to achieve effective universal health coverage. A key aspect of high quality health care and health systems is that they are person-centred, a characteristic that is at the same time intrinsica...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
В 2018 году были опубликованы три независимых отчета, которые призывали уделять особое внимание качеству лечения и всячески улучшать его, чтобы добиться эффективного охвата населения услугами здравоохранения. Ключевым аспектом высококачественных систем медико-санитарного обслуживания является их ориентированность на че...
ru
pair_31384075
The measures for long-term care prevention that the Japanese government had introduced in 2006 were unsuccessful because of the failures to identify high-risk individuals and to enrol enough participants in the community prevention programme. The Japanese government shifted its primary strategy from a high-risk strateg...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
日本政府在 2006 年采取的长期护理预防措施因未能识别高危人群和招募足够的社区预防项目参与者而失败。. 通过改革《长期护理保险法》(Long-term Care Insurance Act),日本政府在 2015 年将其基本战略从高危群体战略转变为以社区为基础的人口战略。该法案强调基于社区的护理与健康的社会决定因素。该法案和政府的长期护理预防计划的灵感来自于一项名为 <i>ikoino saron</i> 的社会参与干预项目,该项目为 65 岁以上的人群举办沙龙。这些沙龙由当地志愿者管理,每月在公共场所举办一两次,步行可达,参与费用较低。在聚会上,老年人可以通过愉悦轻松的项目与他人会面和互动,这些项目时而会颇具教育意义。. 日本是...
zh-cn
pair_31384075
The measures for long-term care prevention that the Japanese government had introduced in 2006 were unsuccessful because of the failures to identify high-risk individuals and to enrol enough participants in the community prevention programme. The Japanese government shifted its primary strategy from a high-risk strateg...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Les mesures pour la prévention des soins de longue durée qui avaient été mises en place par le gouvernement japonais en 2006 ont été inefficaces, en raison de l'impossibilité d'identifier les personnes à haut risque et de faire participer suffisamment de personnes au programme de prévention communautaire. Le gouverneme...
fr
pair_31384075
The measures for long-term care prevention that the Japanese government had introduced in 2006 were unsuccessful because of the failures to identify high-risk individuals and to enrol enough participants in the community prevention programme. The Japanese government shifted its primary strategy from a high-risk strateg...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Las medidas de prevención de cuidados a largo plazo que el gobierno japonés había introducido en 2006 no tuvieron éxito debido a que no se identificaron a las personas de alto riesgo ni se inscribió a un número suficiente de participantes en el programa de prevención comunitaria. El gobierno japonés cambió su estrategi...
es
pair_31384075
The measures for long-term care prevention that the Japanese government had introduced in 2006 were unsuccessful because of the failures to identify high-risk individuals and to enrol enough participants in the community prevention programme. The Japanese government shifted its primary strategy from a high-risk strateg...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Меры по профилактике долгосрочного ухода, внедренные японским правительством в 2006 году, потерпели неудачу из-за того, что не удалось выявить лиц с высоким риском и включить достаточное количество участников в профилактическую программу по месту жительства. Правительство Японии сменило ранее существовавшую основную ст...
ru
pair_31384073
To generate estimates of the global prevalence and incidence of urogenital infection with chlamydia, gonorrhoea, trichomoniasis and syphilis in women and men, aged 15-49 years, in 2016. For chlamydia, gonorrhoea and trichomoniasis, we systematically searched for studies conducted between 2009 and 2016 reporting prevale...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
旨在估计 2016 年 15-49 岁男女泌尿生殖系统感染衣原体病、淋病、滴虫病和梅毒的全球患病率和发病率。. 对于衣原体病、淋病和滴虫病,我们系统搜索了 2009 年至 2016 年间的患病率报告研究。我们还咨询了区域专家。为了生成估计值,我们使用了贝叶斯荟萃分析。对于梅毒,我们汇总分析了使用 Spectrum-STI 生成的全国估计值。. 对于衣原体病、淋病和/或滴虫病,符合要求的有 130 项研究。对于梅毒, Spectrum-STI 数据库包含了同一时期的 978 个数据点。2016 年,全球女性患病率估计值为:衣原体病 3.8%(95% 不确定区间,UI:3.3-4.5);淋病 0.9%(95% UI:0.7–1.1);滴...
zh-cn
pair_31384073
To generate estimates of the global prevalence and incidence of urogenital infection with chlamydia, gonorrhoea, trichomoniasis and syphilis in women and men, aged 15-49 years, in 2016. For chlamydia, gonorrhoea and trichomoniasis, we systematically searched for studies conducted between 2009 and 2016 reporting prevale...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Produire des estimations de la prévalence et de l'incidence mondiales des infections urogénitales dues à la chlamydiose, à la gonorrhée, à la trichomonase et à la syphilis chez les femmes et les hommes de 15 à 49 ans, en 2016. Pour la chlamydiose, la gonorrhée et la trichomonase, nous avons systématiquement recherché l...
fr
pair_31384073
To generate estimates of the global prevalence and incidence of urogenital infection with chlamydia, gonorrhoea, trichomoniasis and syphilis in women and men, aged 15-49 years, in 2016. For chlamydia, gonorrhoea and trichomoniasis, we systematically searched for studies conducted between 2009 and 2016 reporting prevale...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Generar estimaciones de la prevalencia y la incidencia mundiales de la infección urogenital por clamidia, gonorrea, tricomoniasis y sífilis en mujeres y hombres de 15 a 49 años de edad en 2016. Para la clamidia, la gonorrea y la tricomoniasis, se realizaron búsquedas sistemáticas de estudios realizados entre 2009 y 201...
es
pair_31384073
To generate estimates of the global prevalence and incidence of urogenital infection with chlamydia, gonorrhoea, trichomoniasis and syphilis in women and men, aged 15-49 years, in 2016. For chlamydia, gonorrhoea and trichomoniasis, we systematically searched for studies conducted between 2009 and 2016 reporting prevale...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Оценить распространенность в мировом масштабе и частоту урогенитальных инфекций, вызываемых хламидией, а также гонореи, трихомониаза и сифилиса у мужчин и женщин в возрасте от 15 до 49 лет по состоянию на 2016 год. Для хламидиоза, гонореи и трихомониаза авторы провели систематический поиск исследований, выполненных в п...
ru
pair_31385324
The purpose of this study was to explore the relationship of social networking sites (SNSs) addiction on nurses' performance and how this relationship was mediated by task distraction and moderated by self-management. This cross-sectional study is designed to empirically test the relationship of SNSs addiction, task di...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的: 此项研究旨在探讨沉迷社交网站(SNSs)与护士表现之间的关系,并探讨注意力分散和自我管理如何调解这种关系。 设计: 此项横断面研究的目的是为了实证检测沉迷社交网站(SNSs)、注意力分散和自我管理与护士表现之间的关系。 方法通过使用一份基于网络的问卷针对全球护士进行在线调查,收集到了数据,其中调查问卷是通过“谷歌Docs”开发的,并且于2018年8月13日至2018年11月17日在Facebook上发布。Facebook组是通过搜索选定关键词完成。共有45组数据与本研究相关;因此要求这些组的管理员参与这项研究,并在他们的组中发布链接。只有19名小组管理员积极响应,在他们的小组页面上发布了研究工具的链接,共461名小组成员参与...
zh-cn
pair_31385343
To develop enhanced prediction models to update the QUiPP App prototype, a tool providing individualized risk of spontaneous preterm birth (sPTB), for use in women with symptoms of threatened preterm labor (TPTL), incorporating risk factors, transvaginal ultrasound assessment of cervical length (CL) and cervicovaginal ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
QUiPP App v.2预测模型的开发与验证:先兆早产症状妇女的早产预测工具 目标: 开发增强型预测模型,完善先兆早产症状(TPTL)妇女的QUiPP App原型,结合危险因素、经阴道超声评估宫颈长度(CL)和宫颈阴道液定量胎儿纤维粘连蛋白(qfFN)检测结果预测自然早产个体化风险(sPTB)。 方法: 试验参与者是一群妊娠23+0至34+6周显示TPTL症状的孕妇,她们被招募参加2010年10月至2017年10月之间在英国16家医院进行的四项前瞻性群组研究中的一项或几项。训练集包括2017年5月得出结果的所有孕妇(n=1032)。验证集包括2017年6月至2018年3月间收集结果的孕妇(n=506)。针对三种预测变量组合开发了几...
zh-cn
pair_31385343
To develop enhanced prediction models to update the QUiPP App prototype, a tool providing individualized risk of spontaneous preterm birth (sPTB), for use in women with symptoms of threatened preterm labor (TPTL), incorporating risk factors, transvaginal ultrasound assessment of cervical length (CL) and cervicovaginal ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Desarrollo y validación de modelos predictivos para la Aplicación QUiPP v.2: herramienta para predecir el parto pretérmino en mujeres con síntomas de amenaza de parto prematuro OBJETIVO: Desarrollar modelos de predicción mejorados para actualizar el prototipo de la Aplicación QUiPP, una herramienta que proporciona el r...
es
pair_31385368
A species is not native outside its native range, but native range is not precisely defined. The invasion literature contains wide discussion of the core concepts such as naturalization, invasiveness, and ecological impact, but the concept of native range has received so little attention that a formal definition does n...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
物种在其原生地之外的地区会被看作是外来种, 但原生地这个概念本身尚没有准确的定义。入侵生物学相关文献对这个问题的核心概念 (如归化、入侵能力和生态影响) 有广泛的讨论, 然而却很少关注原生地的概念, 以至于对其没有正式的定义。本文探讨了对原生地进行正式定义的诸多阻碍中, 用于划定原生地的时间和空间限制的随意性问题。此外仍存在一些宽泛的问题, 如入侵理论能否用于定义没有非原生地的物种的原生地。翻译:胡怡思;审校:聂永刚.
zh-cn
pair_31385368
A species is not native outside its native range, but native range is not precisely defined. The invasion literature contains wide discussion of the core concepts such as naturalization, invasiveness, and ecological impact, but the concept of native range has received so little attention that a formal definition does n...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Replanteamiento del Concepto de Distribución Nativa Resumen Una especie es no nativa fuera de su distribución nativa, pero este último concepto no está definido con precisión. La literatura sobre las especies invasoras contiene amplias discusiones sobre los conceptos centrales, como la naturalización, la invasividad y ...
es
pair_31385623
Environmental solutions require a decision-making process that is ultimately political, in that they involve decisions with uncertain outcomes and stakeholders with conflicting viewpoints. If this process seeks broad alignment between the government and public, then reconciling conflicting viewpoints is a key to the le...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
环境解决方案需要一个最终落实到政策的决策过程, 其中包括结果不确定的决策和利益相关者的观点冲突。如果要在决策过程中寻求政府和公众之间的广泛共识, 那么协调那些不一致的观点则是决策正当性的关键。我们认为生态基准可以作为强有力的工具, 为推行解决方案所需要的公众支持 (正当性) 和对新条规的遵守 (合法性) 创造共同认识。这是因为生态基准通过提供对共同期望 (如栖息地恢复) 的概念模型, 将围绕解决方案的讨论化抽象为具体。此外, 生态基准包含的对过去 (生态历史) 的叙述重新调整了人们对认知和响应新政策的预期。生态基准为科学家提供了生态系统功能恢复的基准, 同时也为公众和政府提供了讨论解决方案的标准。这种公众问题的社会规范化可能有助于政...
zh-cn
pair_31385623
Environmental solutions require a decision-making process that is ultimately political, in that they involve decisions with uncertain outcomes and stakeholders with conflicting viewpoints. If this process seeks broad alignment between the government and public, then reconciling conflicting viewpoints is a key to the le...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Article impact statement: Ecological history provides legitimacy and confidence for government to collaborate on finding new policies for environmental conservation. Soluciones Ambientales Detonadas por la Historia Ambiental Resumen Las soluciones ambientales requieren un proceso de toma de decisiones que es básicament...
es
pair_31385631
Habitat fragmentation is a primary driver of wildlife loss, and establishment of biological corridors is a common strategy to mitigate this problem. A flagship example is the Mesoamerican Biological Corridor (MBC), which aims to connect protected forest areas between Mexico and Panama to allow dispersal and gene flow o...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
生境破碎化是野生动物数量下降的首要原因, 而应对这一问题的常用策略则是建设生物廊道。一个典型的例子是中美洲生物廊道 (Mesoamerican Biological Corridor), 它的建立旨在连接墨西哥和巴拿马之间的森林保护地, 帮助森林中的生物进行扩散和基因交流。然而, 由于中美洲范围内的森林在持续退化, 中美洲生物廊道的功能已受到质疑, 但目前仍没有该地区物种分布的可靠评估。大型哺乳动物可以作为森林功能的指示种, 因此, 我们评估了中美洲生物廊道最狭窄的地区--巴拿马地峡大型哺乳动物的保护状况。我们利用大规模红外相机调查和贝叶斯框架下的分级多物种占有模型, 估计了九种中大型哺乳动物的分布情况, 并发展出一个生境占有率加权...
zh-cn
pair_31385631
Habitat fragmentation is a primary driver of wildlife loss, and establishment of biological corridors is a common strategy to mitigate this problem. A flagship example is the Mesoamerican Biological Corridor (MBC), which aims to connect protected forest areas between Mexico and Panama to allow dispersal and gene flow o...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Efectividad de Panamá como un Puente Terrestre Intercontinental para Mamíferos Mayores Resumen La fragmentación del hábitat es un causante primario de la pérdida de biodiversidad, y el establecimiento de corredores biológicos es una estrategia común para mitigar este problema. El Corredor Biológico Mesoamericano (CBM) ...
es
pair_31386221
Brazil hosts the largest expanse of tropical ecosystems within protected areas (PAs), which shelter biodiversity and support traditional human populations. We assessed the vulnerability to climate change of 993 terrestrial and coastal-marine Brazilian PAs by combining indicators of climatic-change hazard with indicator...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
巴西是保护地体系中热带生态系统面积最大的国家, 这里的保护地支撑着生物多样性及当地的传统人群。我们结合气候变化灾害指标与保护地恢复力指标 (面积、原生植被覆盖、气候驱动植被转变的可能性), 评估了巴西 993 个陆地和近岸海域保护地对气候变化响应的脆弱性。这些指标的结合有助于确定广泛的气候变化适应机制。结果显示, 有十七个保护地 (20,611 平方公里) 被评为高度脆弱, 它们主要分布在大西洋森林 (7 个保护地) 、塞拉多 (6 个) 和亚马逊 (4 个); 两百五十八个主要位于亚马逊流域的保护地 (756,569 平方公里) 被评为中度脆弱。在亚马逊和塞拉多西部, 虽然保护地的保护情况总体良好, 但预测的气候变化严峻且气候驱动...
zh-cn
pair_31386221
Brazil hosts the largest expanse of tropical ecosystems within protected areas (PAs), which shelter biodiversity and support traditional human populations. We assessed the vulnerability to climate change of 993 terrestrial and coastal-marine Brazilian PAs by combining indicators of climatic-change hazard with indicator...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Evaluación de la Vulnerabilidad y Adaptación al Cambio Climático de Áreas Protegidas en Brasil Resumen Brasil alberga la mayor extensión de ecosistemas tropicales dentro de áreas protegidas (AP), que protegen la biodiversidad y sustentan a poblaciones humanas tradicionales. Evaluamos la vulnerabilidad al cambio climáti...
es
pair_23668200
To explore the efficacy and prognosis of first-line autologous hematopoietic stem cell transplantation (ASCT) for newly diagnosed patients with multiple myeloma(MM). From January 2005 to December 31, 2012, 60 patients with MM were enrolled. All patients received thalidomide or/and bortezomib-based induction therapy, th...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 评价一线自体造血干细胞移植(ASCT)治疗初诊多发性骨髓瘤(MM)患者的疗效,分析其预后相关因素。方法 对给予沙利度胺和(或)硼替佐米为基础的诱导化疗并获得部分反应以上疗效的60例初诊MM患者,进行一线ASCT治疗,分析其总生存(OS)和无进展生存(PFS),并探讨国际分期系统(ISS)分期、治疗反应、荧光原位杂交(FISH)检测细胞遗传学异常与患者预后的相关性。结果 随访至2012年12月31日,中位随访36.8(12.0~102.5)个月。全组患者预期中位OS和PFS时间分别为未达到和 86.5个月。60例患者移植后均获得≥非常好的部分反应(VGPR),其中34例(56.7%)为完全反应(CR)。获得CR者的PFS时间较获...
zh-cn
pair_23668201
To explore the efficacy and safety of bortezomib (btz) based chemotherapy in multiple myeloma (MM) patients with renal-function impairment (RI). Fifty-six MM patients with impaired renal function treated with bortazomib based regimens in our single center were retrospectively analyzed. The median age was 59 (ranged 30-...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 观察以硼替佐米(Btz)为基础的化疗方案在合并肾功能不全的多发性骨髓瘤(MM)患者中的疗效及安全性。方法 回顾性分析56例伴有肾功能不全且接受以Btz为基础方案化疗的MM患者的临床资料。结果 56例患者中位年龄59(30~77)岁,κ型22例(39.3%),λ型32例(57.1%);其中IgD型9例(16.1%),轻链型14例(25.0%)。中位内生肌酐清除率(CrCl)为25.33(7.23~59.55)ml/min,轻、中、重度肾功能损害者分别为6、35、15例。34例可判断MM疗效的患者中总体反应率为82.4%,其中完全反应(CR)率32.4%,非常好的部分反应(VGPR)率为17.6%,部分反应(PR)率为26.5%。...
zh-cn
pair_23668202
To evaluate the efficacy and safety of bortezomib retreatment in 76 patients with relapsed/refractory multiple myeloma (MM), who previously responded to bortezomib. Retrospective analysis of 76 MM patients, who had achieved at least a partial response (PR) on initial bortezomib therapy in our hospital from May 2006 to ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨硼替佐米再治疗多发性骨髓瘤(MM)的疗效及安全性。方法 回顾性分析2006年5月至2011年8月收治的76例硼替佐米初次治疗疗效达部分反应(PR)以上,复发或疾病进展后予以硼替佐米再治疗的MM患者,评价硼替佐米再治疗的疗效及不良反应。结果 硼替佐米再治疗MM的总有效率(ORR)为60.5%,其中完全反应(CR)率 6.5%,非常好的部分反应(VGPR)率15.8%,PR率38.2%。按硼替佐米初治后疗效分为CR、VGPR、PR组,3组患者再治疗后ORR分别为84.6%、73.1%和43.2%。按患者硼替佐米再治疗后疗效分成2组,达到PR及以上的为有效组,未达到PR的为无效组,两组自硼替佐米再治疗后中位疾病无进展生存期分别为...
zh-cn
pair_23668203
To evaluate the efficacy and safety of dose-reduced intravenous busulfan, cyclophosphamide and etoposide (BCV) as conditioning for autologous stem cell transplantation (ASCT) in multiple myeloma (MM). From September 2007 to September 2010, thirty-two ASCT-eligible patients with MM received high dose melphalan (HDM) as ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 评价BCV(白消安+环磷酰胺+足叶乙甙)预处理方案在多发性骨髓瘤(MM)自体造血干细胞移植(ASCT)患者的疗效和安全性。方法 2007年9月至2010年9月采用大剂量马法兰对32例MM患者行ASCT预处理(HDM组),中位年龄53.5(30~63)岁;2010年10月至2012年10月采用BCV方案(白消安静脉给药、总剂量9.6 mg/kg)对38例MM患者行ASCT预处理(BCV组),中位年龄54(35~64)岁。结果 两组患者MM分型、Durie-Salmon分期、国际分期体系(ISS)分期及接受一、二、三线以上治疗患者比例差异均无统计学意义。BCV组与HDM组比较,中性粒细胞植入时间[10.5(9~15)d对11(9~...
zh-cn
pair_23668204
To study the humoral immunity reconstitution and its relationship with infection in patients with multiple myeloma (MM) after undergoing autologous hematopoietic stem cell transplantation (auto-HSCT). Forty-two MM patients undergoing auto-HSCT were included in this study. Peripheral blood were obtained for immunoglobul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 观察多发性骨髓瘤(MM)患者在接受自体造血干细胞移植(auto-HSCT)后体液免疫重建的规律及其与移植后感染的关系。方法 分析接受auto-HSCT的42例MM患者,分别检测其在移植前、移植后1、3、6、12、18、24个月的外周血IgG、IgA、IgM水平,并记录其在移植后1~24个月间感染的发生情况。结果 IgA水平在移植后6个月内[(0.75±0.59)g/L]显著低于移植前水平[(1.04±0.70)g/L],之后缓慢上升,移植后9个月[(0.99±0.52) g/L]达到移植前水平。IgM水平在移植后1个月内[(0.28±0.15)g/L]低于移植前水平[(0.45±0.26)g/L],在移植后3个月[(0.50±...
zh-cn
pair_23668205
To investigate the effect of nuclear receptor inhibitor importazole (IPZ) on cell cycle and apoptosis of multiple myeloma (MM) cells and its regulatory mechanisms. MM cell lines RPMI 8226 and NCI-H929 cells were treated with different concentrations of IPZ. Cell viability was detected through MTT method. Cell cycle and...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨入核受体抑制剂Importazole(IPZ)对多发性骨髓瘤(MM)细胞周期、凋亡的影响及其可能的作用机制。方法 用不同浓度IPZ处理骨髓瘤细胞系RPMI 8226和NCI-H929细胞,用四甲基偶氮唑盐比色(MTT)法检测细胞活性,用流式细胞术测定细胞周期和细胞凋亡,Western blot法和凝胶迁移实验(EMSA)检测核内NF-κB的蛋白表达和DNA结合活性。结果 IPZ以时间浓度依赖方式抑制RPMI 8226和NCI-H929细胞增殖及诱导凋亡,作用48 h的半数抑制浓度(IC50)分别为(4.43±0.41)、(4.78±0.35)μmol/L。4 μmol/L IPZ分别作用RPMI 8226和NCI-H929...
zh-cn
pair_23668206
To study the clinical significance of abnormal protein bands (APB) in multiple myeloma (MM) patients treated with bortezomib-based induction regimen and autologous stem cell transplantation (ASCT). Sixty-eight MM patients submitted to bortezomib-based induction therapy and ASCT from January 2007 to July 2012 were retro...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 研究接受含硼替佐米方案诱导序贯自体造血干细胞移植(ASCT)治疗多发性骨髓瘤(MM)患者出现异常蛋白条带(APB)的临床意义。方法 回顾性分析2007年1月至2012年7月接受含硼替佐米方案诱导序贯ASCT治疗68例MM患者的资料,采用免疫固定电泳方法检测M蛋白。结果 33例(48.5%)MM患者出现APB,2例轻链型在诱导化疗达完全缓解(CR)后移植前首次出现APB,31例患者在移植后中位时间104(33~404)d首次出现APB,APB出现例次中位数为2(1~7)次,持续中位时间为105(35~801)d。33例出现APB组患者移植后疗效显著高于35例未出现APB(Non-APB)组患者,CR+非常好的部分缓解(VGPR)...
zh-cn
pair_23668207
To investigate the relationship between the expression level of microRNA 92a (miR-92a) and del(13q14) and the prognosis of MM patients, and to explore the pathway that miR-92a involved. Bone marrow samples from 53 newly diagnosed MM patients were collected, del(13q14) was analyzed by interphase fluorescence in situ hyb...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨多发性骨髓瘤(MM)患者微小RNA-92a(miR-92a)的表达水平及其与染色体del(13q14)和患者预后的关系,并进一步探索miR-92a作用的信号通路。方法 收集53例初诊MM患者骨髓标本,用CD138磁珠分选浆细胞,然后用间期荧光原位杂交技术检测染色体del(13q14)情况;用实时定量 PCR检测浆细胞中miR-92a的表达;用miR-92a前体转染MM细胞株(LP-1、U266和JJN3),Western blot法检测c-jun蛋白表达水平。结果 53例MM患者中31例(58.5%)染色体del(13q14)阳性;伴有和不伴有del(13q14)的患者miR-92a相对中位表达水平分别为27.36±2.6...
zh-cn
pair_23668209
To improve the understanding of the clinical and laboratory features of the IgM multiple myeloma (MM). The clinical data of four cases of IgM MM patients were collected, their clinical and laboratory features were summarized and analyzed. Four patients met the criteria of IgM MM. They were all male. The age at the diag...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 提高对IgM型多发性骨髓瘤(MM)患者临床及实验室特征的认识。方法 收集4例IgM型MM患者的临床资料,对其临床及实验室特征进行总结、分析。结果 4例患者符合IgM型MM的诊断。4例均为男性,年龄54~69岁,初发症状包括骨痛、高黏滞血症、出血,3例轻链为κ型,1例为λ型,Durie-Salmon(D-S)分期均为ⅢA期,国际分期系统(ISS)分期:Ⅰ期1例,Ⅱ期3例。平均IgM 83.6(52.9~111.0)g/L,HGB 79.5(61.0~105.0)g/L,血钙3.20(2.11~6.00)mmol/L,肌酐104.3(56.0~171.0)μmol/L,骨髓浆细胞比例0.558(0.290~0.775),3例存在骨...
zh-cn
pair_23668210
To analyze the efficacy and side effects of the combination regimen containing bortezomib, cyclophosphamide and dexamethasone(BCD) in the treatment of primary systemic amyloidosis (PSA). The clinical manifestation, efficacy and side effects of 22 PSA patients after treatment were retrospectively analyzed. Of the 22 PSA...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨硼替佐米联合地塞米松、环磷酰胺治疗原发系统性淀粉样变性的疗效以及不良反应。方法 回顾性分析22 例原发系统性淀粉样变性患者临床表现、使用硼替佐米联合地塞米松、环磷酰胺治疗的疗效以及不良反应。结果 22例患者中初治9例,复发13例,中位血清游离轻链140 mg/L。PCR法检测黑色素瘤相关基因(MAGE C1/CT7)阳性率88.9%,可先于骨髓细胞流式细胞术以及形态学检测方法检出阳性克隆性浆细胞的存在。中位治疗2个疗程。初治患者总有效率88.9%;脏器缓解率55.6%,2例猝死。复发患者总有效率46.2%,脏器缓解率30.7%。22例患者中出现周围神经病变10例,无Ⅲ~Ⅳ级神经病变出现。1例出现肝功能衰竭。1例因置入气管支...
zh-cn
pair_23676979
The improved survival of patients with lung cancer depends on early diagnosis of lung cancer. However, the traditional diagnostic techniques have several limitations. Mass spectrometry (MS) has been applied as a core technology for cancer diagnosis in preliminary proteomic studies. The aim of this study is to explore t...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 早期诊断是提高肺癌生存率的关键,传统的肺癌诊断技术仍存在一定局限性。鉴于近年来以质谱为核心技术的肿瘤蛋白组学在癌症诊断方面的初步研究,本研究探索性应用基质辅助激光解析电离飞行时间质谱(matrix assisted laser desorption ionization-time of flight-mass spectrometry, MALDI-TOF-MS)分析非小细胞肺癌(non-small cell lung cancer, NSCLC)患者和健康人群的血清差异多肽,以建立NSCLC的血清分类模型。方法 将年龄和性别匹配的133例NSCLC患者和132例健康者血清标本按照3:1的比例随机分为两组:训练组由100...
zh-cn
pair_23676980
Icotinib hydrochloride is the third single target EGFR-TKI used in clinical treatment of advanced non-small cell lung cancer (NSCLC). Clinical research reports on its efficacy and survival in patients with Recurrent Advanced NSCLC are still little.The aim of this study is to evaluate the efficacy and survival of Icotin...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 盐酸埃克替尼是第三个在临床上应用于晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)治疗的单靶点表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor tyrosine kinase inhibitor, EGFR-TKI),关于其在复发肺癌患者中的疗效及生存的临床研究报道仍甚少。本研究回顾性分析盐酸埃克替尼在晚期复发NSCLC中的疗效及安全性,并探讨影响因素。 方法 对2009年3月-2012年7月北京胸科医院收治的60例接受盐酸埃克替尼治疗的晚期复发NSCLC患者的临床资料进行回顾性分析。结果 60例均可评价疗效,总有效率45%,疾病控制...
zh-cn
pair_23676981
Treatment of pulmonary carcinoid is a comprehensive modality focusing on surgery. Thus, accurate and timely preoperative and intraoperative pathological diagnoses are very crucial. The aim of this study is to retrospectively analyze the pathological characteristics of pulmonary carcinoid, its natural history, and patte...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 肺类癌采取以手术为主的多学科治疗,准确及时的病理诊断至关重要。本研究探讨肺类癌的病理特质,结合回顾性分析患者的转归预后,为临床决策提供依据。方法 收集支气管肺内发生的类癌手术标本32例,回顾性分析患者相关的临床病理资料,系统研究病灶病理学表现与临床诊断和治疗效果的相关性。结果 32例肺类癌患者中,典型类癌18例,不典型类癌14例;男女性别比为2.2:1;平均年龄(44±15)岁;近半数患者无症状;肿瘤最大径(3.1±1.3) cm;绝大多数为I期患者(84.4%, 27/32),余IIa期2例,IIIa期2例,IV期1例;随访时间为5.2年-9.7年;其中典型类癌随访15例,5年无进展生存率为100%;不典型类癌随访12...
zh-cn
pair_23676982
The clinical evidences are not sufficient on the proton beam therapy of lung cancer for lacking of the RCTs on the comparing the proton with the photon beam in lung cancer radiotherapy. The aim of this study is to evaluate the dosimetry superiority of the proton beam and provide more valuable evidences to the clinical ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
背景与目的 由于缺乏质子治疗与传统光子治疗比较的临床随机对照研究,导致质子治疗在肺癌放疗中的应用没有充足的临床证据。本研究旨在探讨质子射线在肺癌放疗中的剂量学优势,以期为临床提供有价值的循证医学依据。方法 计算机检索Cochrane Library、PubMed、EMbase、中国生物医学文献数据库、中国学术期刊全文数据库和中国科技期刊数据库,同时辅助其它检索,搜集所有比较质子射线与光子射线治疗肺癌的剂量学研究的文章,应用RevMan 5.2软件对满足条件的数据进行meta分析。结果 6篇文献纳入本次研究。质子射线与光子射线三维适形放疗(three-dimensional conformal radiotherapy, 3D-CRT...
zh-cn
pair_23676984
Interstitial lung disease is one of the most serious side effects caused by lung cancer treatment. Due to the complexity diagnosis and variability of the disease, it is often not diagnosied and treated in time, even endanger the patient's life and affect the patient's prognosis. The mechanism of interstitial pneumonia ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
间质性肺病是肺癌相关治疗引起的严重副反应之一,因诊断的复杂性及病情的多变性往往不能及时诊治甚至危及患者的生命,严重影响患者的预后。放、化疗及靶向治疗导致间质性肺炎的机制及相关因素尚不完全清楚。因此,如何减少、早期发现及诊治肺癌相关治疗引起的间质性肺病成为今后肺癌治疗过程中不可忽略的一个问题。
zh-cn
pair_23678195
To describe breastfeeding practices in rural China using globally recommended indicators and to compare them with practices in neighbouring countries and large emerging economies. A community-based, cross-sectional survey of 2354 children younger than 2 years in 26 poor, rural counties in 12 central and western provinc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
使用全球推荐的指标描述中国农村的母乳喂养实践,并将其与邻国和大型新兴经济体的实践进行比较。 对12 个中西部省份贫穷乡村的2354 名2 岁以下儿童开展以社区为基础的横断面调查。探讨婴幼儿喂养和社会经济、人口和卫生服务因素之间的关联,并将比例与来自中国和其他国家的最新数据进行比较。 总体而言,98.3%的婴儿接受母乳喂养。然而,新生儿早开奶率只有59.4%(即在出生后的1小时内);分别只有55.5%和9.4%的婴儿持续接受母乳喂养到1 至2 岁,6 个月以下的婴儿纯母乳喂养率只有28.7%。早开奶与至少五次产前检查呈正相关(调整后的优势比,aOR:3.48;P < 0.001),与剖宫产(aOR:0.53;P<0.001)或在县级及...
zh-cn
pair_23678195
To describe breastfeeding practices in rural China using globally recommended indicators and to compare them with practices in neighbouring countries and large emerging economies. A community-based, cross-sectional survey of 2354 children younger than 2 years in 26 poor, rural counties in 12 central and western provinc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Décrire les pratiques d'allaitement maternel dans la Chine rurale en utilisant des indicateurs recommandés au niveau mondial et en les comparant avec les usages des pays voisins et des grandes économies émergentes. Une étude transversale a été menée, sur base communautaire, auprès de 2354 enfants âgés de moins de 2 ans...
fr
pair_23678195
To describe breastfeeding practices in rural China using globally recommended indicators and to compare them with practices in neighbouring countries and large emerging economies. A community-based, cross-sectional survey of 2354 children younger than 2 years in 26 poor, rural counties in 12 central and western provinc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Describir las prácticas de lactancia en las zonas rurales de China por medio de los indicadores recomendados a nivel internacional y compararlas con las prácticas de los países vecinos y de las grandes economías emergentes. Se llevó a cabo una encuesta transversal comunitaria de 2354 niños menores de 2 años en 26 conda...
es
pair_23678195
To describe breastfeeding practices in rural China using globally recommended indicators and to compare them with practices in neighbouring countries and large emerging economies. A community-based, cross-sectional survey of 2354 children younger than 2 years in 26 poor, rural counties in 12 central and western provinc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Описать практику грудного вскармливания в сельских районах Китая, используя всемирно рекомендованные индикаторы, и сравнить их с практикой в соседних странах и крупных странах с переходной экономикой. Было проведено перекрестное обследование на уровне общины 2354 детей в возрасте до двух лет в 26 бедных сельских района...
ru
pair_23678196
To determine smoking trends in Japan in comparison with lung cancer mortality. Age-specific smoking prevalence among cohorts born between 1897 and 1985 were determined for the period 1949-2010. The percentages of the cohorts born between 1893 and 1979 who initiated smoking early (e.g. before the age of 20 years) were d...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
比较肺癌死亡率,确定日本的吸烟趋势。 确定1949 至2010 年期间在1897 至1985 年间出生的出生队列中特定年龄人群的吸烟率。确定1893 至1979 年间出生并且早期开始吸烟(例如,20 岁之前)的出生队列的百分比。将结果与1868 至1968 年间出生、年龄在40-84 岁的出生队列的肺癌死亡率进行比较。 在男性中,吸烟率普遍较高,出生在20 世纪50 年代末之前的男性尤为如此,而早期开始吸烟的情况则相当少见。最近出生的男性群体中早期开始吸烟的情况最为常见,他们表现出相对较低的吸烟率。在女性中,吸烟率普遍较低,早期开始吸烟的情况非常罕见,尤其是出生在20 世纪30 年代末和20 世纪40 年代末之前的女性。最近出生的女...
zh-cn
pair_23678196
To determine smoking trends in Japan in comparison with lung cancer mortality. Age-specific smoking prevalence among cohorts born between 1897 and 1985 were determined for the period 1949-2010. The percentages of the cohorts born between 1893 and 1979 who initiated smoking early (e.g. before the age of 20 years) were d...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Déterminer les tendances du tabagisme au Japon comparées à la mortalité par cancer du poumon. Les taux de prévalence du tabagisme en fonction de l'âge, parmi les cohortes nées entre 1897 et 1985, ont été déterminés pour la période 1949-2010. Les pourcentages des cohortes nées entre 1893 et 1979, ayant commencé à fumer ...
fr
pair_23678196
To determine smoking trends in Japan in comparison with lung cancer mortality. Age-specific smoking prevalence among cohorts born between 1897 and 1985 were determined for the period 1949-2010. The percentages of the cohorts born between 1893 and 1979 who initiated smoking early (e.g. before the age of 20 years) were d...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Conocer las prevalencias del tabaquismo en Japón respecto a la mortalidad por cáncer de pulmón. Se determinaron los índices de prevalencia del tabaquismo por edad entre cohortes nacidas entre 1897 y 1985 para el periodo 1949–2010. Se establecieron los porcentajes de las cohortes nacidas entre 1893 y 1979 que iniciaron ...
es
pair_23678196
To determine smoking trends in Japan in comparison with lung cancer mortality. Age-specific smoking prevalence among cohorts born between 1897 and 1985 were determined for the period 1949-2010. The percentages of the cohorts born between 1893 and 1979 who initiated smoking early (e.g. before the age of 20 years) were d...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Исследовать тенденции курения в Японии в сравнении с уровнем смертности от рака легких. Были определены средние уровни распространенности курения среди когорт детей, родившихся между 1897 и 1985 гг., в период с 1949 по 2010 годы. Рассчитаны проценты от когорт, родившихся между 1893 и 1979 гг., начавших курение рано (т....
ru
pair_23678197
To assess how changes in socioeconomic and public health determinants may have contributed to the reduction in stunting prevalence seen among Cambodian children from 2000 to 2010. A nationally representative sample of 10 366 children younger than 5 years was obtained from pooled data of cross-sectional surveys conducte...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
评估社会经济和公众健康决定因素的变化对降低2000 至2010 年柬埔寨儿童发育迟缓发病率可能有何种贡献。 从2000、2005 年和2010 年进行的横断面调查的汇总数据中获取未满5 岁的10366 名儿童的全国代表性样本。作者采用多元层次逻辑模型考查儿童发育迟缓发病率与时间以及某些决定因素之间的关联。他们对在2010 年通过进一步改善公众健康指标可能实现的发育障碍发病率的变化进行估计。 儿童发育迟缓的相关因素有:儿童的性别和年龄、出生类型、产妇身高、产妇身体质量指标、之前的出生时间间隔、家庭成员人数、家庭财富指数得分、卫生设施更好的普及、出现腹泻情况、父母的教育程度、孕产妇吸烟与否以及母亲是否出生在红色高棉饥荒期间。在过去的十年...
zh-cn
pair_23678197
To assess how changes in socioeconomic and public health determinants may have contributed to the reduction in stunting prevalence seen among Cambodian children from 2000 to 2010. A nationally representative sample of 10 366 children younger than 5 years was obtained from pooled data of cross-sectional surveys conducte...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Évaluer comment les changements dans les déterminants socio-économiques et de santé publique peuvent avoir contribué à la réduction de la prévalence du retard de croissance chez les enfants cambodgiens de 2000 à 2010. Un échantillon national représentatif de 10 366 enfants de moins de 5 ans a été obtenu à partir de don...
fr
pair_23678197
To assess how changes in socioeconomic and public health determinants may have contributed to the reduction in stunting prevalence seen among Cambodian children from 2000 to 2010. A nationally representative sample of 10 366 children younger than 5 years was obtained from pooled data of cross-sectional surveys conducte...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Evaluar cómo los cambios en los factores determinantes socioeconómicos y relativos a la salud pública pueden haber contribuido en la disminución de la prevalencia del retraso en el crecimiento entre niños camboyanos observada entre 2000 y 2010. Se obtuvo una muestra representativa a nivel nacional de 10 366 niños menor...
es
pair_23678197
To assess how changes in socioeconomic and public health determinants may have contributed to the reduction in stunting prevalence seen among Cambodian children from 2000 to 2010. A nationally representative sample of 10 366 children younger than 5 years was obtained from pooled data of cross-sectional surveys conducte...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Оценить, как изменения в социально-экономической и общественной детерминантах здоровья способствовали сокращению отставания в росте, наблюдаемого среди камбоджийских детей с 2000 по 2010 годы. Из объединенных данных перекрестных опросов, проведенных в Камбодже в 2000, 2005 и 2010 годах, были получены данные национально...
ru
pair_23678198
To describe the use of episiotomy among Vietnamese-born women in Australia, including risk factors for, and pregnancy outcomes associated with, episiotomy. This population-based, retrospective cohort study included data on 598 305 singleton, term (i.e. ≥ 37 weeks' gestation) and vertex-presenting vaginal births between...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
描述澳大利亚的越南女人接受会阴侧切手术的情况,包括会阴切开术的风险因素和相关的妊娠结局。 这项基于人群的回顾性队列研究包括2001 年至2010 年之间598305 个单胎、足月(即37 孕周)和头位阴道分娩的数据。数据来源于经链接、确证的群体水平出生和住院数据集。使用列联表和多变量分析比较接受和不接受会阴切开术的女性的风险因素及妊娠结局。 较之生于澳大利亚的女性15.1% 的手术比率,在12208 名生于越南的女性中的会阴侧切手术比率为29.9%。在越南出生的女性中,较之不接受会阴切开术的患者,接受此手术的患者在私人医院进行分娩时更有可能引产或接受器械助产。在这些女性中,会阴切开术与产后出血(调整后的优势比,aOR:1.26;95...
zh-cn
pair_23678198
To describe the use of episiotomy among Vietnamese-born women in Australia, including risk factors for, and pregnancy outcomes associated with, episiotomy. This population-based, retrospective cohort study included data on 598 305 singleton, term (i.e. ≥ 37 weeks' gestation) and vertex-presenting vaginal births between...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Décrire le recours à l'épisiotomie chez les femmes nées au Viet Nam et accouchant en Australie, y compris les facteurs de risque et les répercussions sur la grossesse associées à l'épisiotomie. Cette étude de cohorte rétrospective axée sur la population a inclus des données de 598 305 singletons nés par voie vaginale, ...
fr
pair_23678198
To describe the use of episiotomy among Vietnamese-born women in Australia, including risk factors for, and pregnancy outcomes associated with, episiotomy. This population-based, retrospective cohort study included data on 598 305 singleton, term (i.e. ≥ 37 weeks' gestation) and vertex-presenting vaginal births between...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Describir el uso de la episiotomía entre mujeres vietnamitas en Australia, incluidos los factores de riesgo y los resultados en el embarazo asociados a esta. Este estudio de cohortes retrospectivo basado en la población incluyó datos de 598 305 partos vaginales únicos, prematuros (esto es, ≥ 37 semanas de gestación) y ...
es
pair_23678198
To describe the use of episiotomy among Vietnamese-born women in Australia, including risk factors for, and pregnancy outcomes associated with, episiotomy. This population-based, retrospective cohort study included data on 598 305 singleton, term (i.e. ≥ 37 weeks' gestation) and vertex-presenting vaginal births between...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Описать применение эпизиотомии среди вьетнамских женщин в Австралии, включая факторы риска эпизиотомии и связанных с ней исходов беременности. Данное проспективное когортное исследование населения включало данные по 598 305 одноплодным беременностям, срокам (т.е. вынашивание ≥ 37 недель) и родоразрешениям при затылочно...
ru
pair_23678199
To evaluate the risk of recurrence of adverse perinatal outcomes in second pregnancies in developing countries. Data from the 2004-2008 Global Survey on Maternal and Perinatal Health were used to determine the outcomes of singleton second pregnancies for 61 780 women in 23 developing countries. The mother-infant pairs ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
评估发展中国家第二次怀孕围生期不良结局复发的风险。 使用孕产妇和围生期卫生2004–2008 年全球调查的数据确定在23 个发展中国家61780 名妇女单胎第二次怀孕的结局。对母婴对随访至出院或者进行7 天的产后随访。 在第二次怀孕结束时,在第一次怀孕中有过死产的妇女(n = 1261)或者新生儿死亡(n = 1052)的妇女比没有经历此类结局的妇女的婴儿更有可能生产体重< 1500 g(优势比,OR:分别为2.52 和2.78)或者体重为1500–2499 g(OR:分别为1.22 和1.60)的婴儿,或生出的婴儿更可能需要进入特护病房(OR:分别为1.64 和1.68)。在其第二次妊娠晚期,在第一次怀孕时发生过死产的妇女再次发生...
zh-cn
pair_23678199
To evaluate the risk of recurrence of adverse perinatal outcomes in second pregnancies in developing countries. Data from the 2004-2008 Global Survey on Maternal and Perinatal Health were used to determine the outcomes of singleton second pregnancies for 61 780 women in 23 developing countries. The mother-infant pairs ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Évaluer le risque de récidive des issues périnatales indésirables lors des deuxièmes grossesses dans les pays en développement. Les données de l'Enquête mondiale sur la santé maternelle et périnatale menée sur la période 2004-2008 ont été utilisées pour déterminer les résultats des deuxièmes grossesses uniques auprès d...
fr
pair_23678199
To evaluate the risk of recurrence of adverse perinatal outcomes in second pregnancies in developing countries. Data from the 2004-2008 Global Survey on Maternal and Perinatal Health were used to determine the outcomes of singleton second pregnancies for 61 780 women in 23 developing countries. The mother-infant pairs ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Evaluar el riesgo de recurrencia de los resultados perinatales adversos de los segundos embarazos en países en desarrollo. Se emplearon datos de la Encuesta Global en Salud Materna y Perinatal realizada entre 2004 y 2008 para determinar los resultados del segundo embarazo de feto único de 61 780 mujeres en 23 países en...
es
pair_23678199
To evaluate the risk of recurrence of adverse perinatal outcomes in second pregnancies in developing countries. Data from the 2004-2008 Global Survey on Maternal and Perinatal Health were used to determine the outcomes of singleton second pregnancies for 61 780 women in 23 developing countries. The mother-infant pairs ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Оценить риск повторения неблагоприятных перинатальных исходов в ходе второй беременности в развивающихся странах. Данные, полученные из проведенного в 2004-2008 годах Глобального обследования материнского и перинатального здоровья, были использованы для определения исходов одноплодной второй беременности 61 780 женщин ...
ru
pair_23678200
To evaluate the screening measures that would have been required to assess all travellers at risk of transporting A(H1N1)pdm09 out of Mexico by air at the start of the 2009 pandemic. Data from flight itineraries for travellers who flew from Mexico were used to estimate the number of international airports where health ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
对评估2009 年流感大流行初期有可能从墨西哥向外传播甲型H1N1 pdm09 的所有航空旅客所需的筛查措施进行评价。 使用从墨西哥起飞的旅客的飞行旅程数据估计需要卫生检查措施的国际机场数量,以及必须接受检查的旅客数量,以评估在2009 年甲型H1N1 流感初始阶段可能从墨西哥向外传播H1N1 流感病毒的所有航空旅客。 在墨西哥36 个机场进行出境检查,或者在26 个其他国家的82 个机场对墨西哥飞来的直达航班的入境旅客进行检查,从而实现对流感大流行初始阶段可能从墨西哥向外传播甲型H1N1 pdm09 的所有航空乘客的评估。要评估每个具有传播甲型H1N1 pdm09 风险的乘客,需要对来自墨西哥的直航或转机的116 名旅客进行入境检...
zh-cn
pair_23678200
To evaluate the screening measures that would have been required to assess all travellers at risk of transporting A(H1N1)pdm09 out of Mexico by air at the start of the 2009 pandemic. Data from flight itineraries for travellers who flew from Mexico were used to estimate the number of international airports where health ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Évaluer les mesures de dépistage qui auraient été nécessaires pour dépister tous les voyageurs potentiellement porteurs du virus A(H1N1)pdm09 au départ du Mexique par avion au début de la pandémie de 2009. Les données provenant des itinéraires de vol des voyageurs qui ont quitté le Mexique en avion ont été utilisées po...
fr
pair_23678200
To evaluate the screening measures that would have been required to assess all travellers at risk of transporting A(H1N1)pdm09 out of Mexico by air at the start of the 2009 pandemic. Data from flight itineraries for travellers who flew from Mexico were used to estimate the number of international airports where health ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Evaluar las medidas de detección sistemática que tendrían que haberse aplicado con el fin de analizar a todos los pasajeros de avión con riesgo de transportar el virus de la gripe A (H1N1) pdm09 desde México al principio de la pandemia de 2009. Se analizaron los datos de los itinerarios de vuelo de los pasajeros que vo...
es
pair_23678200
To evaluate the screening measures that would have been required to assess all travellers at risk of transporting A(H1N1)pdm09 out of Mexico by air at the start of the 2009 pandemic. Data from flight itineraries for travellers who flew from Mexico were used to estimate the number of international airports where health ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Оценить меры по скринингу, которые могли бы потребоваться для проверки всех пассажиров на предмет риска переноса A(H1N1)pdm09 из Мексики по воздуху в начале пандемии 2009 г. Данные о маршрутах полетов пассажиров, которые вылетели из Мексики, были использованы для оценки числа международных аэропортов, где требовались м...
ru
pair_23678201
To establish estimates of viral suppression in low- and middle-income countries (LMICs) in patients who received antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection. Data on viral suppression after 12 months of ART in LMICs were collected from articles published in 2003 to 2011 and from abstra...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
估计中低收入国家(LMIC)接受艾滋病病毒(HIV)感染抗逆转录病毒治疗(ART)的患者的病毒抑制率。 从2003 至2011 年发表的文章以及2009 至2011 年之间举行的会议摘要中收集中低收入国家患者在接受ART的12 个月之后的病毒抑制数据。使用治疗和意向治疗人群的集合比例作为汇总估计值。对研究(<i>I</i><sup>2</sup> > 75%)的异质群体使用随机效应模型。 总体而言,涉及48 个群组和30016 名个人的49 项研究符合纳入标准。在抑制阈值为每毫升血浆病毒核糖核酸(RNA)拷贝数为300 至500 时,84.3%(95% 置信区间,CI:80.4–87.9)的集合治疗人群和70.5%(95% CI:6...
zh-cn
pair_23678201
To establish estimates of viral suppression in low- and middle-income countries (LMICs) in patients who received antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection. Data on viral suppression after 12 months of ART in LMICs were collected from articles published in 2003 to 2011 and from abstra...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Estimer la suppression virale dans les pays à revenu faible et intermédiaire (PRFI) chez des patients ayant reçu un traitement antirétroviral (TAR) contre l'infection due au virus de l'immunodéficience humaine (VIH). Des données sur la suppression virale après 12 mois de TAR dans les PRFI ont été recueillies à partir d...
fr
pair_23678201
To establish estimates of viral suppression in low- and middle-income countries (LMICs) in patients who received antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection. Data on viral suppression after 12 months of ART in LMICs were collected from articles published in 2003 to 2011 and from abstra...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Calcular la supresión viral en países de renta baja y media (PRBM) en pacientes que recibieron terapia con antiretrovirales (TAR) para tratar la infección por el virus de inmunodeficiencia humana (VIH). Se recabaron datos sobre la supresión viral tras 12 meses de TAR basados en artículos publicados entre 2003 y 2011, a...
es
pair_23678201
To establish estimates of viral suppression in low- and middle-income countries (LMICs) in patients who received antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection. Data on viral suppression after 12 months of ART in LMICs were collected from articles published in 2003 to 2011 and from abstra...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Оценка частоты вирусной супрессии в странах с низким и средним уровнем дохода (СНСД) у пациентов, которые прошли антиретровирусную терапию (АРТ) против инфекции вируса иммунодефицита человека (ВИЧ). Данные о вирусной супрессии через 12 месяцев после начала АРТ в СНСД были собраны из статей, опубликованных в период с 20...
ru
pair_23683412
To explore the feasibility of magnetic resonance cell imaging technology by using polyethylene imine (PEI)-coated magnetic nanoparticles of Fe₄O₄ (PEI-Fe₄O₄-MNPs) to track cell biology behavior. Endocytic PEI-Fe₄O₄-MNPs in SHI-1 cells were observed by transmission electron microscopy (TEM) . Iron contents of nano-label...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 初步探讨利用聚乙烯亚胺包被的四氧化三铁(PEI-Fe₄O₄)磁性纳米颗粒进行磁共振细胞影像技术跟踪细胞生物学行为的可行性。方法 以人急性单核细胞白血病细胞株SHI-1为对象,用透射电镜观察PEI-Fe₄O₄磁性纳米颗粒能否被细胞内吞;用电感耦合等离子发射光谱仪及普鲁士蓝染色观察影响细胞磁性纳米颗粒载量的因素;用CCK-8法检测PEI-Fe₄O₄对SHI-1细胞增殖的影响;用流式细胞术(FCM)检测PEI- Fe₄O₄磁性纳米颗粒对细胞分化的影响;以甲基纤维素半固体培养基培养法检测PEI-Fe₄O₄对细胞集落形成能力的影响。以未经PEI-Fe₄O₄磁性纳米颗粒处理的SHI-1细胞作为对照组。结果 PEI-Fe₄O₄磁性纳米颗粒能...
zh-cn
pair_23683413
To investigate the function of abnormal fibrinogen in two inherited dysfibrinogenemia pedigrees. Routine coagulation tests were conducted in the probands and related family members. The antigen and activity levels of fibrinogen were detected by immunoturbidimetry assay and clauss assay, respectively. All the exons and ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 对两个遗传性异常纤维蛋白原血症家系的突变纤维蛋白原(Fg)进行功能研究。方法 常规筛查凝血功能;Fg抗原和活性分别用免疫比浊法和Clauss法测定;抽提DNA,对Fg 3个基因(FGA、 FGB和FGG)以及抗凝血酶基因(AT3)所有外显子及侧翼序列进行PCR扩增、测序及分析;采用常规血栓弹力图(TEG)和功能性Fg TEG检查对家系B先证者及其父亲进行凝血功能的综合评价及血浆功能性Fg评估;应用Western blot 检测血浆Fg肽链分子量;采用Fg动态聚集曲线和纤维蛋白溶解曲线实验检测血浆Fg的功能。结果 2例先证者凝血酶原时间(TT)和爬虫酶凝固时间(RT)明显延长,Fg活性仅为0.5 g/L和0.6 g/L,但其抗原...
zh-cn
pair_23683414
To establish a feasible protocol to provide genetic diagnosis and prenatal diagnosis in Chinese hemophilia patients and their relatives by direct exon sequencing. In our study, genetic diagnosis was performed on 5 unrelated families with informed consent, which included 3 pregnant women who asked for prenatal diagnosis...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探索应用FⅨ基因全外显子测序技术进行血友病B(HB)基因携带者检测和产前基因诊断。方法 在取得5个无血缘关系的汉族HB家系成员知情同意后,采集相关家系成员标本。3个产前诊断标本中,2例为胎儿脐血标本,1例为羊水标本。从标本中提取基因组DNA,通过PCR扩增FⅨ基因所有外显子及其侧翼序列,将产物进行全外显子直接测序。结果 5个家系的HB患者以及FⅨ基因携带者共检出5种突变:c.484 C>T (p.R162X)、c.1022G>A (p.R341Q)、c.1135C>T (p.R379X)、c.799C>T (p.H267Y)和c.1232G>T (p.S411I)。在产前诊断中,发现1例c.484 C>T (p.R162X)突...
zh-cn
pair_23683415
To identify the genotype and pathogenesis in four Chinese pedigrees with Factor Ⅻ deficiency. Activated partial thromboplastin time (APTT), FⅫ procoagulant activity (FⅫ∶C), FⅫ antigen(FⅫ∶Ag)and other coagulant parameters were detected. The FⅫ deficiency Pedigree members,all exons,boundary introns including the splice j...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨4个遗传性凝血因子Ⅻ(FⅫ)缺陷症家系基因突变及分子发病机制。方法 检测凝血酶原时间(PT)、APTT、FⅫ促凝活性(FⅫ∶C)和FⅫ抗原(FⅫ∶Ag)等凝血指标;PCR扩增FⅫ基因的全部外显子及侧翼序列,PCR产物纯化后测序;在野生型pIRES2-EGFP FⅫ表达质粒上构建突变体FⅫ表达质粒,瞬时转染COS7细胞,测定细胞裂解液和培养上清中FⅫ∶Ag水平和FⅫ∶C。结果 4例先证者APPT均明显延长,FⅫ∶C均<2%,FⅫ∶Ag亦同步下降至1%。4个家系均检出常见的FⅫ46C/T多态性。家系A先证者检出5741-5742delCA(His101Gln)及7142insertC(Lys346Gln)双重杂合突变;家系B先...
zh-cn
pair_23683416
To analyze coincidence rate of acute myeloid leukemia (AML) sub-typing between transmission electron microscopy (TEM) and clinical discharge diagnosis. Reviewing sub-typing results of TEM, light microscopy, flow cytometric analyzing, molecular biological detection and karyotype in 793 AML cases, comparing their coincid...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 分析透射电子显微镜(电镜)对急性髓系白血病(AML)诊断分型的临床符合率。方法 回顾性分析793例AML患者经电镜、细胞形态学、细胞化学、流式细胞术、分子生物学和染色体核型等方法分型结果,比较电镜及其他检测方法对AML分型与临床诊断的符合率,分析电镜对AML分型的优势。结果 6种检测方法AML分型符合率由高到低依次为电镜检测(63%)、细胞化学分析(59%)、细胞形态学分析(52%)、流式细胞术分析(47%)、染色体核型分析(26%)和分子生物学检测(23%)。电镜检测对M1、M2a、M4、M5、M6、M7、t(8;21) 和t(15;17)亚型的符合率分别为39%、34%、17%、74%、50%、73%、87%和89%。结论...
zh-cn
pair_23683417
This study was aimed to observe the efficacy of autologous stem cell transplantation (ASCT) for adult patients with acute lymphoblastic leukemia (ALL), and investigate related prognostic factors. A total of 86 adult ALL patients underwent ASCT in Institute of Hematology and Blood Disease Hospital from November 2001 to ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 观察成人急性淋巴细胞白血病(ALL)患者行自体造血干细胞移植(auto-HSCT)的疗效,并探讨相关的预后危险因素。方法 对2001年11月至2012年1月行auto-HSCT的86例成人ALL患者进行随访,并对所有患者的临床特征及治疗转归进行回顾性分析,应用Kaplan-Meier法进行生存分析,用COX回归模型评估独立预后因素。结果 可评价疗效的81例auto-HSCT患者中标危47例,高危34例。标危组患者1、3、5、10年无病生存(LFS)率分别为(82.3±5.7)%、(76.9±6.5)%、(74.1±6.8)%、(67.4±8.9)%;累积复发(RR)率分别为(13.6±5.2)%、(21.6±6.4)%、(24...
zh-cn
pair_23683418
To investigate mesenchymal stem cells (MSCs) immunosuppressive activity in the presence of interferon-gamma (IFN-γ) to reveal synergistic immunomodulatory effects of IFN-γ and MSCs. ① MSCs were cultured in the presence or absence of IFN-γ(100 ng/ml), the supernatants were collected for measurements of PGE2、HGF and TGF-...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨干扰素-γ(IFN-γ)对正常人骨髓间充质干细胞(MSC)免疫活性的影响,阐明IFN-γ与MSC在免疫抑制中的协同作用。方法 ① ELISA法检测IFN-γ(终浓度100 ng/ml)对正常人骨髓来源MSC前列腺素E2(PGE2)、肝细胞生长因子(HGF)和转化生长因子β1(TGF-β1)表达水平的影响。②RT-PCR法检测100 ng/ml IFN-γ作用下MSC内吲哚胺2,3-双加氧酶(IDO)基因表达水平变化。③ 体外刺激正常人外周血T细胞增殖,并与正常人骨髓来源MSC共培养,检测T细胞增殖水平;在共培养体系中分别加入重组人IFN-γ(100 ng/ml)及鼠抗人IFN-γ单克隆抗体(单抗,5 μg/ml),检测T细...
zh-cn
pair_23683419
To observe the therapeutic effect and major complications of haploidentical nonmyeloablative allogeneic peripheral blood stem cell transplantation (NST) for refractory or relapsed leukemia. The results of 30 patients, including 14 cases of acute myeloid leukemia (AML), 11 cases of acute lymphoblastic leukemia (ALL), 5 ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 观察单倍体非清髓造血干细胞移植(NST)治疗难治复发性白血病的疗效及主要并发症。方法 对我中心2000年8月至2009年4月进行单倍体NST治疗的30例难治复发性白血病结果进行分析。其中急性髓系白血病14例,急性淋巴细胞白血病11例,慢性髓性白血病(加速、急变期)5例。预处理方案为氟达拉滨、抗胸腺细胞球蛋白、环磷酰胺、全身照射联合阿糖胞苷或白消安。移植物抗宿主病(GVHD)预防方案为环孢素、霉酚酸酯、CD25单抗联合间充质干细胞。结果 植入情况:30例患者中26例为完全供者嵌合,4例为混合嵌合转变为完全供者嵌合。移植后中性粒细胞>0.5×109/L恢复平均时间为11(9~16)d,PLT>20×109/L恢复平均时间为17(1...
zh-cn
pair_23683420
To investigate leukemia transformation rate in myelodysplastic syndrome (MDS) and the relationship with quantitative and type of chromosomal abnormality. This study retrospectively analyzed and rediagnosed 138 MDS patients with complete data, investigated the rate and time of leukemia transformation, and analyzed chara...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨骨髓增生异常综合征(MDS)患者向急性髓系白血病(AML)的转化率与染色体异常核型数量及类型的关系。方法 对138例资料完整的MDS患者进行回顾性分析,按WHO 2001标准重新诊断分型,统计MDS患者AML转化率(转白率)、MDS转化为AML时间(转白时间),G显带分析患者初治时染色体核型。结果 138例MDS患者中29例转化为AML,转白率为21.01%,中位转白时间为8(3~24)个月。其中正常核型、染色体异常核型分裂相≤5个、染色体异常核型分裂相>5个的转白率分别为6.2%、23.8%、38.5%,中位转白时间为17(13~22)、13(5~23)、7(3~10)个月。随着染色体异常核型数量增多,转白率有升高的趋势...
zh-cn
pair_23683421
To further understand the clinical features of non-gastric mucosa-associated lymphoid tissue (MALT) lymphoma and investigate its suitable treatment. A retrospective survey of 57 non-gastric MATL lymphoma patients pathologically confirmed in our hospital from 1999 to 2011. The median age was 58 years (range 14-86 years)...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 进一步了解非胃黏膜相关淋巴组织(MALT)淋巴瘤患者的临床特点并探讨合理的治疗方法。方法 回顾性分析57例经病理确诊的非胃MALT淋巴瘤患者资料,对其临床特点和治疗疗效进行分析。结果 57例患者中,男32例、女25例,中位年龄58(14~86)岁,常见发病部位为肺及支气管(17例,29.8%)、肠道(16例,28.1%)、涎腺(8例,14.0%)、眼及附属器(7例,12.3%)等。临床分期为Ⅰ~Ⅱ期者35例(61.4%),Ⅲ~Ⅳ期者22例(38.6%),淋巴结受累者26例(45.6%),多个结外器官受累者7例(12.5%)。56例接受治疗的患者完全缓解率为66.0%,总反应率85.7%。中位随访时间52个月,患者5年总生存(O...
zh-cn
pair_23683422
To report the diagnosis, differential diagnosis and treatment of a rare case of primary bone marrow CD8+ cytotoxic T-cell lymphoma coexpressed CD20. The clinical characteristics, therapeutic course and the outcome of this patient were reviewed. Meanwhile, a series of examinations including morphology, flow cytometry, i...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 报道1例罕见的原发于骨髓伴CD20表达的CD8阳性细胞毒性T细胞淋巴瘤患者的诊断、鉴别诊断和治疗经过。方法 分析患者的发病经过、临床特点、治疗反应和转归,对患者的骨髓和皮肤标本进行包括形态学、流式细胞术、免疫组织化学和分子生物学在内的系列检测以助诊断和鉴别诊断。结果 患者骨髓中有大量异常T淋巴细胞浸润,骨髓和皮肤标本经流式细胞术和免疫组化检查发现CD20弱表达、CD8、CD2、CD3、CD5及TIA阳性,PAX-5、CD4、CD56、CD57、CD30、ALK-1、P53及TdT等均阴性,Ki-67阳性≈5%,诊断为伴CD20表达的CD8阳性细胞毒性T细胞淋巴瘤,原发于骨髓,临床呈惰性经过,3年后侵犯皮肤和其他脏器并迅速进展,...
zh-cn
pair_23683423
To study improvement of detection of paternally herited fetal mutant genes for β-globin in maternal plasma by PNA clamp to seek a noninvasive prenatal diagnostic method for β-thalassemia. A total of 38 maternal blood samples were collected at 7 to 20 weeks of gestation, samples in which the father carried CD41-42 mutat...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨利用肽核酸夹提高孕妇血浆胎儿父源性β珠蛋白突变基因的检出率,为地中海贫血(地贫)无创性产前诊断提供依据。方法 选择妊娠7~20周的孕妇共38例,丈夫基因型为41-42M/N,而孕妇基因型正常或为其他β地贫基因突变。以羊水、脐带血或出生后婴儿外周血标本的检测结果作为金标准对照。用QIAamp DNA Blood Mini试剂盒提取孕妇血浆总游离DNA,再将总游离DNA经过10 g/L琼脂糖凝胶电泳后回收长度100~300 bp的DNA,然后应用回收后的DNA并加肽核酸夹进行PCR扩增,最后采用反向斑点杂交确定基因型并与金标准检测结果进行比较。同时设置扩增方法不同的A、B对照组,对照组A应用总游离DNA并加肽核酸夹,对照组B应...
zh-cn
pair_23683424
To detect p15(INK4B) methylation levels and the kinetics of the methylation status before and after decitabine to explore its influences on prognosis and response to decitabine in myelodysplastic syndromes (MDS) patients. We examined 261 MDS patients (143 male and 118 female) with the median age of 52 years (32-78). Of...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 通过检测初诊骨髓增生异常综合征(MDS)患者p15(INK4B)甲基化水平,观察地西他滨治疗前、后p15(INK4B)甲基化状态变化,探讨p15(INK4B)甲基化水平与预后的关系及其对地西他滨疗效的影响。方法 261例初诊MDS患者,其中男143例,女118例,中位年龄52(32~78)岁。低危组172例(低危104例、中危-1 68例),高危组89例(中危-2 52例、高危37例)。收集患者骨髓单个核细胞,采用甲基化特异性PCR(MSP)检测p15(INK4B)甲基化水平,按p15(INK4B)甲基化程度对患者进行生存分析。采用MSP方法分别检测58例MDS患者地西他滨治疗前及治疗2个疗程后骨髓p15(INK4B)甲基化水...
zh-cn
pair_23683425
To analyze the clinical characteristics and risk factors on responses and survival of myelodysplastic syndromes (MDS) patients with paroxysmal nocturnal hemoglobinuria (PNH) clones. The clinical data of 31 MDS cases with PNH clones from October 2004 to June 2012 were retrospectively analyzed to reveal the influence of ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 分析伴阵发性睡眠性血红蛋白尿症(PNH)克隆的骨髓增生异常综合征(MDS)的临床特点及其对疗效和预后的影响。方法 回顾性分析2004年10月至2012年6月诊断明确的31例伴PNH克隆的MDS患者临床资料,分析其临床特点及PNH克隆大小对疗效和生存的影响。结果 ①31例患者均行染色体核型分析,未见分裂象者1例,正常核型23例(76.7%),异常核型7例(23.3%)。其中+8者3例,-Y 2例,del(7q) 1例,Xp+1例。根据IPSS积分系统,低危组1例,中危-1组27例,中危-2组2例,高危组1例,治疗有效组与无效或稳定组间感染发生率、中性粒细胞绝对计数(ANC)、网织红细胞(Ret)计数及IPSS积分差异均有统计学意...
zh-cn
pair_23683426
To investigate thiopurine S-methyltransferase (TPMT) activity and gene promoter polymorphism to probe its significance of individual chemotherapy in acute lymphoblastic leukemia (ALL) children. HPLC method was carried out to determine TPMT activity (n=100), which activity at newly diagnosed. At the same time determinat...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨巯基嘌呤甲基转移酶(TPMT)活性和其遗传多态性在儿童急性淋巴细胞白血病(ALL)个体化治疗中的临床意义。方法 运用高效液相色谱法(HPLC)对100例初诊ALL患儿、180名健康儿童进行TPMT活性检测。采用在线Primer3 软件设计引物,对30例具有临床事件的患儿进行TPMT基因DNA测序。分析TPMT活性、遗传多态性与临床不良反应的相关性。TPMT活性以在单位时间(1 h)内单位质量的血红蛋白(Hb,g)催化生成的2-氨基-6-甲基巯基嘌呤(6-MTG)的量(nmol)表示。结果 100例初诊ALL患儿TPMT活性为(31.72±10.31)nmol·g⁻¹Hb·h⁻¹,180名健康儿童TPMT活性为(30.70±...
zh-cn
pair_23688745
To investigate the clinicopathological features of primary gastrointestinal non-Hodgkin's lymphomas (PGI-NHL) and their prognostic values. The clinical and pathological data of 216 patients diagnosed as PGI-NHL from Zhejiang Cancer Hospital were analyzed retrospectively. χ² test, log-liner model analysis, COX proportio...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 探讨原发胃肠道非霍奇金淋巴瘤(Primary gastrointestinal non-Hodgkin’s lymphomas,PGI-NHL)患者病理特征及其与预后的关系。方法 回顾性分析216例PGI-NHL患者病理特征和临床资料,采用SAS 8.2统计学软件对统计数据进行χ²检验、对数线性模型、COX比例风险模型及Life Table生存分析。结果 216例患者中男121例,女95例,男女比例为1.27∶1,中位发病年龄56.5(8~89)岁。原发于胃147例(68.1%)、回盲部25例(11.6%)、大肠20例(9.3%)、小肠17例(7.9%)、食管及阑尾各1例(共0.9%)、5例同时累及多个部位(2.3%)。B细胞...
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pair_23688746
To evaluate the efficacy and safety of a chemoimmunotherapy regimen of rituximab, fludarabine and cyclophosphamide (FCR) for patients with chronic lymphocytic leukemia(CLL). The clinical data of 26 CLL patients receiving FCR regimen in our hospital from April 2003 to January 2012 were analyzed retrospectively. Patients...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
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目的 评价利妥昔单抗联合氟达拉滨和环磷酰胺(FCR)方案治疗慢性淋巴细胞白血病(CLL)的疗效和安全性。方法 回顾性分析2003年4月至2012年1月应用FCR方案治疗的26例CLL患者病例资料。根据患者的Rai危险度分层、β2-微球蛋白(β2-MG)、LDH、ZAP-70表达、CD38表达、细胞遗传学和免疫球蛋白重链可变区基因(IgVH)突变状态等指标进行分组,行疗效和生存分析。同时评价FCR方案的安全性。结果 26例患者完全缓解(CR)10例(38.5%),部分缓解(PR)10例(38.5%),总反应率(ORR)76.9%。中位随访30(3~98)个月,中位无进展生存(PFS)时间 42(16~68)个月,总生存(OS)时间63...
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pair_23688747
To investigate and compare the clinical implications of p16 deletion in childhood and adult B-lineage acute lymphoblastic leukemia (B-ALL). A total of 129 cases of de novo childhood (73 cases) and adult (56 cases) B-ALL were examined genetically and immunologically using G-banding techniqhe, interphase fluorescence in ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
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目的 探讨p16基因缺失对儿童与成人急性B淋巴细胞白血病(B-ALL)预后的影响。方法 采用流式细胞术、G显带核型分析和间期荧光原位杂交(I-FISH)技术,对73例儿童和56例成人B-ALL患者进行免疫学和细胞遗传学检测,并回顾分析其临床资料。结果 I-FISH检测发现儿童组患者中p16基因纯合性缺失、杂合性缺失和无缺失的发生率分别为24.7%(18例)、6.8%(5例)、68.5%(50例),成人组患者分别为14.3%(8例)、8.9%(5例)、76.8%(43例);儿童组与成人组p16基因缺失发生率比较差异无统计学意义(P=0.338);分别对两组患者中p16基因缺失与无缺失者临床特征进行比较,外周血WBC、骨髓原始细胞比例、...
zh-cn
pair_23688748
To explore efficacy of imatinib for patients with chronic myeloid leukemia(CML) and its resistance-related factors during the treatment. The clinical data of 214 CML patients received imatinib were analyzed respectively in our hospital from April 2005 to December 2010. The therapy history and efficacy of regular follow...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
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目的 探讨伊马替尼治疗慢性髓性白血病(CML)过程中发生耐药的相关因素。方法 回顾性分析2005年4月至2010年12月接受伊马替尼治疗的214例CML患者临床资料,随访患者治疗情况、疗效,分析影响耐药的各种因素。应用COX比例风险回归模型对影响耐药的各种因素进行单因素和多因素分析。结果 截至随访终点,31例(14.5%)患者出现伊马替尼耐药,其中1例为加速期患者,2例为急变期患者;完全细胞遗传学反应(CCyR)率为69.2%,主要分子学反应(MMR)率为31.3%。以207例慢性期患者进行COX分析,单因素分析显示,治疗前病程、HGB水平、WBC、是否获得CCyR、是否获得MMR为伊马替尼耐药的影响因素。多因素COX回归分析表明,...
zh-cn
pair_23688749
To analyze outcomes and prognostic factors of children with B-cell non-Hodgkin lymphoma (B-NHL). One hundred and four newly diagnosed B-NHL children were enrolled in protocol of B-NHL 2001. The statistics were performed by SPSS 13.0. Of 104 children (79 males, the median age of 7.1 years), 60, 32 and 4 patients were di...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 总结分析儿童B细胞非霍奇金淋巴瘤 (B-NHL)短程化疗方案的远期疗效及预后影响因素。方法 前瞻性制定B-NHL的诊断与治疗方案。收集接受短程B-NHL 2001化疗方案治疗和随访的104例B-NHL患儿资料,并进行统计学分析。结果 104例B-NHL患儿中,男79例、女25例,中位年龄7.1(0.9~16.0)岁;96例病理类型明确的患儿中,Burkitt淋巴瘤60例、弥漫大B细胞淋巴瘤32例、介于弥漫大B细胞淋巴瘤与霍奇金淋巴瘤的B细胞淋巴瘤4例;另有8例为通过体液形态学和免疫表型分析诊断。诊断时Ⅰ、Ⅱ、Ⅲ和Ⅳ期患儿分别为4、27、55和18例;低危、中危和高危组患儿分别为1、26和77例。采用短程B-NHL 2001化疗...
zh-cn
pair_23688750
To evaluate the expression of interleukin-6 (IL-6) and its clinicopathological significance in Castleman's disease (CD). Clinical data and paraffin blocks of 92 CD patients and 20 cases of lymph node reactive hyperplasia (LRH) as a control group were collected from department of pathology of Peking University Health Sc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 研究Castleman病(Castleman’s disease,CD)患者IL-6的表达情况,并分析其临床病理学意义。方法 收集92例CD患者标本,免疫组化法检测其IL-6的表达情况,并以20例淋巴结反应性增生(Lymph node reactive hyperplasia,LRH)患者标本作为对照组。结果 92例CD患者中男56例,女36例,中位年龄41(4~90)岁。其中多中心型(MCD)42例,单中心型(UCD)50例;浆细胞型(PC-CD)62例,透明血管型(HV-CD)30例。所有患者HIV检测均阴性。92例CD患者中77例(83.7%)IL-6表达阳性,20例LRH患者仅1例(5.0%)表达阳性。各型CD患者中I...
zh-cn
pair_23688751
To compare the efficacy and safety of low-dose rituximab combined with different dosage of glucocorticoids for immune thrombocytopenia (ITP). Seventy-four patients (35 male, median age 34 years, range 18-70 years) including 60 newly-diagnosed, 6 persistent, 5 chronic and 3 refractory patients were enrolled in this stud...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
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目的 比较两种糖皮质激素联合小剂量利妥昔单方案治疗成人原发免疫性血小板减少症(ITP)的疗效。方法 74例ITP患者,男35例、女39例,中位年龄34(18~70)岁,新诊断的ITP 60例、持续性ITP 6例、慢性ITP 5例、难治性ITP 3例。按糖皮质激素治疗方案随机分为①对照组(36例):地塞米松40 mg/d 第1~4天口服; 利妥昔单抗100 mg 第7、14、21、28天静脉滴注。②试验组(38例):地塞米松40 mg/d 第1~4天口服;泼尼松60 mg/d 第5~7天、30 mg/d 第8~14天、20 mg/d 第15~21天、10 mg/d 第22~28天口服;利妥昔单抗100 mg第7、14、21、28天静脉...
zh-cn
pair_23688752
To evaluate the efficacy and safety of itraconazole for secondary prophylaxis of previous proven or probable invasive fungal infection (IFI) in patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation (HSCT) in agranulocytosis state. A phase IV prospective, open-label, multicenter trial wa...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 对有侵袭性真菌感染(IFI)病史的血液系统疾病患者在接受化疗或造血干细胞移植处于粒细胞缺乏(粒缺)状态时予以伊曲康唑二次预防,以评估其疗效及安全性。方法 研究对象均为血液系统疾病接受化疗或造血干细胞移植患者,入组年龄18~65 岁,并在以往治疗过程中存在IFI、有现症真菌感染、严重脏器功能受损者均予以排除。所有患者均在中性粒细胞<1.5×10⁹/L开始予以伊曲康唑二次预防,伊曲康唑静脉滴注200 mg,每日2次,第1、2天作为负荷剂量,第3天起伊曲康唑静脉针剂200 mg,每日1次,直到真菌感染危险期结束(化疗患者中性粒细胞>0.5×10⁹/L,骨髓移植患者中性粒细胞>1.0×10⁹/L)。主要终点是在二次预防结束时及结束7 ...
zh-cn
pair_23688753
To study the effect of transforming growth factor-β activated kinase-1 (TAK1) gene silencing on the proliferation and apoptosis of Kasumi-1 cells induced by arsenic trioxide (As₂O₃). Acute myeloid leukemia with t(8;21) cell line Kasumi-1 cells were treated with As₂O₃ or in combination with TAK1 siRNA interference techn...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
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目的 利用RNA干扰技术研究沉默转化生长因子β激活激酶(TAK1)对三氧化二砷(As₂O₃)诱导的急性髓系白血病(AML)细胞增殖和凋亡的影响。方法 以伴t(8;21)的AML细胞株Kasumi-1为对象,用CCK-8法检测As₂O₃对Kasumi-1细胞的增殖抑制作用;Western blot方法检测As₂O₃作用不同时间后Kasumi-1细胞磷酸化c-Jun N端激酶(P-JNK)的表达;以TAK1 特异的siRNA转染Kasumi-1细胞后用As₂O₃处理细胞作为实验组,同时设立对照组,检测P-JNK表达水平,比较不同处理条件下细胞凋亡率、集落形成率。结果 不同浓度As₂O₃作用于Kasumi-1细胞后,细胞增殖抑制率呈浓度依...
zh-cn
pair_23688754
To develop a novel real-time PCR for sensitively quantitative detection of JAK2 V617F allele burden in peripheral blood. Based on the real-time allele-specific PCR (AS-qPCR), the locked nucleic acid (LNA)-modified oligonucleotide probe was used for selectively blocking amplification of wild-type alleles in AS-qPCR, and...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的 建立一种定量检测外周血细胞酪氨酸激酶2(JAK2)基因V617F突变率的等位基因特异性实时荧光定量PCR(AS-qPCR)方法。方法 在AS-qPCR基础上,引入1条锁核酸(LNA)修饰的寡核苷酸探针,用以选择性抑制AS-qPCR中突变引物对野生等位基因的非特异性扩增,定量检测JAK2 V617F突变率,称之为AS-LNA-qPCR法。通过AS-LNA-qPCR法测定样本的循环阈值(Ct值),根据AS-LNA-qPCR法检测不同JAK2 V617F突变率标准品的Ct值,绘制标准曲线,根据标准曲线直接获得检测样本中JAK2 V617F突变率。我们对该方法标准品的批内、批间检测结果进行了评价,并对623名表观健康人外周血细胞基因组...
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