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pair_29888738
The human act of wandering across landscapes and cityscapes has carved the research interests of scholars in cultural, urban, and historical geography, as well as in the humanities. Here we call for-and take the first steps toward-a historical geography of wandering that is pursued in the head rather than with the legs...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
人类在地景与城市景观之间的漫游行动,开拓了文化、城市与历史地理学者以及人文学者的研究旨趣。我们于此呼吁在脑中进行、而非透过双脚进行的漫游历史地理学,并向该目标初步迈进。我们通过分析心灵漫游的视听设置,如何开启心灵历史地理学所面临的认识论与本体论问题。此一设置同时将心灵漫游模式化成为在不同历史时刻的概念化,并旨在引发拜访者的心灵巡迴。通过这麽做,本研究意图同时展现并颠覆身体与心灵、内在与外在、注意与无意、动态与静态之间的关系,以及重要的是,档案与抗拒档案取得之间的关系。我们反思自身如何以创意实践中拾获的方法,点缀传统历史与地理的学术探问。我们特别考量此般实践对于我们如何概念化档案所带来的挑战——特别是当关注焦点包含短暂易变的心灵现象之...
zh-cn
pair_29888738
The human act of wandering across landscapes and cityscapes has carved the research interests of scholars in cultural, urban, and historical geography, as well as in the humanities. Here we call for-and take the first steps toward-a historical geography of wandering that is pursued in the head rather than with the legs...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La acción humana de deambular a través de paisajes rurales y urbanos ha tallado los intereses investigativos de estudiosos en geografía cultural, urbana e histórica, lo mismo que en las humanidades. Aquí nosotros clamamos ––y damos los primeros pasos al respecto–– por una geografía histórica del deambular que se persig...
es
pair_29888784
Issues of normativity (responding in a typical or average fashion) and desirability (the tendency for raters to endorse positive characteristics rather than neutral or more negative ones) are common in areas of the social sciences that frequently utilize profile correlations to measure dyadic similarity. They have impl...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
常态(以典型或一般方式回应)以及可取性(评估者认同正面而不是中性或负面特点的 倾向)是经常运用刨面相关性来测量二元相似性的社会科学领域中普遍存在的问题。这些问题对于家庭问题学者也有影响。该研究中,我们使用既存数据来对常态以及可取性对于家庭互动宏观层面观测的潜在影响进行初步,有限的考察。我们提出了一个实证案例,该案例使用家庭互动q-sort 评估并将观测评估中差异分解为不同部分。我们发现较高水平的常态以及可取性,表明评估中可能存在的可靠性以及有效性。虽然结果提出了一个有意思的开始,但由于使用q-sort方法以及实验工具有限的背景和应用,这些研究结果有局限性。我们讨论了这些局限性以及对于常态和可取性的其他解释还有对未来研究的意义。.
zh-cn
pair_29888784
Issues of normativity (responding in a typical or average fashion) and desirability (the tendency for raters to endorse positive characteristics rather than neutral or more negative ones) are common in areas of the social sciences that frequently utilize profile correlations to measure dyadic similarity. They have impl...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Las cuestiones de normatividad (responder de una forma típica o promedio) y de deseabilidad (la tendencia de los calificadores a avalar características positivas en lugar de neutras o más negativas) son comunes en las áreas de las ciencias sociales que con frecuencia utilizan las correlaciones de los perfiles para medi...
es
pair_29890865
Elevated progesterone levels on the day of trigger negatively impact the outcome of assisted reproductive technique (ART) treatment and forced ovarian stimulation might be a cause of progesterone elevation during ovarian stimulation. To analyze the impact of forced and prolonged stimulation on the progesterone elevatio...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
摘要 诱发当天孕酮水平升高对辅助生殖技术(ART)的结果产生负面影响, 强的卵巢刺激可能是卵巢刺激过程中孕酮过早升高的原因。为了分析强的和长时间刺激对孕酮升高的影响, 来自Ensure研究的数据对卵巢刺激第8天后单用卵泡刺激素a进行刺激(CFA组)、与用CFA+重组(rec)卵泡刺激素(FSH)进行激素刺激( CFA-plus组)进行了分析比较。在Ensure研究中, 268名患者接受了100μg CFA的卵巢刺激, 128名患者接受了重组FSH的卵巢刺激。来自CFA组的总共35名患者(13.1%)在单用CFA刺激后接受hCG诱发, 233名患者(86.9%)从第8天开始需要额外的rec FSH以满足诱发标准。CFA-plus组的9...
zh-cn
pair_29890868
Pheochromocytoma (PH) is a tumor that arises from chromaffin cells of the adrenal medulla. Though being this benign neoplasm very rare in pregnancies, lack of treatment nevertheless causes high mortality rates for both the mother and the fetus. Classic symptoms related to PH are hypertension, abdominal pain, diaphoresi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
摘要 嗜铬细胞瘤(PH)是由肾上腺髓质的嗜铬细胞产生的肿瘤。虽然这种良性肿瘤在怀孕期间非常罕见, 但治疗不合适会导致母亲和胎儿的高死亡率。与PH相关的典型症状是高血压、腹痛、发汗和头痛, 但它很容易被误诊为妊娠期高血压或先兆子痫。表面上看, 该病是散发的, 但有一些遗传性疾病易发此病(例如多发性内分泌腺瘤病2A型和2B型)。该病需要进行个体管理, 因为没有一种方案适合这种复杂和罕见的情况。本文描述了我们在一位合并PH的年轻妊娠患者身上的临床和外科方面的治疗经验, 事实证明用具有特异性和唯一性药物疗效的多沙唑嗪、用皮质类固醇和密切监测胎儿健康是有效的治疗方法。.
zh-cn
pair_29893071
In recent years, gene engineering is developing rapidly and many recombinant proteins have been expressed. The use of plant bioreactor to express specific pharmaceutical proteins provides a new way for the prevention and treatment of some important diseases in human beings. Nowadays, chloroplast genetic transformation ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
近年来,基因工程技术发展迅速,许多重组蛋白得以表达。其中利用植物生物反应器表达特异药物蛋白为人类一些重要疾病的预防和治疗提供了新途径。植物叶绿体遗传转化和表达系统成为目前植物生物反应器的研究热点。因结构和遗传上的特殊性,高等植物叶绿体在重组蛋白表达方面具有独特优势,外源基因表达量高、定点整合,而且叶绿体母系遗传特性保证了生物安全性。很多重要药用蛋白质在植物叶绿体中表达成功。烟草作为高等植物叶绿体转化模式植物,在疫苗抗原、抗体等药物蛋白和其他重要重组蛋白表达方面取得显著进展。高等植物叶绿体遗传转化也为叶绿体基因的表达和调控机制的研究提供新的技术和方法。文中从叶绿体遗传转化原理、载体构建、重组蛋白和重要药物蛋白在叶绿体中的表达以及重组蛋...
zh-cn
pair_29893072
Stem cell research has become a frontier in the field of life sciences, and provides an ideal model for exploring developmental biology problems such as embryogenesis, histiocytosis, and gene expression regulation, as well as opens up new doors for clinical tissue defective and inheritance diseases. Among them, menstru...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
干细胞研究已成为当今生命科学领域中的前沿和热点问题,该研究为探讨胚胎发生、组织细胞分化以及基因表达调控等生物学问题提供了理想的模型,同时也为临床组织缺陷性疾病和遗传性疾病的细胞治疗和基因治疗开辟了新的手段。其中,经血源性子宫内膜干细胞 (Menstrual blood-derived stem cells,MenSCs) 来源丰富,具有多向分化潜能和较低的免疫排斥的特性,可以实现个体化治疗,是临床最具有应用优势的干细胞。脑与脊髓作为中枢神经系统,其损伤极为常见,致死率和致残率居各类创伤之首。与周围神经系统损伤相比,中枢神经受损后恢复较为困难,其治疗仍缺乏突破。而MenSCs的治疗有希望解决此难题,故结合近年来国内外对MenSCs 的...
zh-cn
pair_29893073
Spt proteins are defined as a large family of transcription regulators of the yeast Saccharomyces cerevisiae. They are crucial components of the SAGA complex that regulates transcription through interaction with the TATA box in the upstream region of the target genes. About 10% of total gene transcriptions are related ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Spt 是一大类参与酿酒酵母转录调控的蛋白质。Spt 蛋白是SAGA 复合体的组成部分,该复合体与基因上游TATA 框区域相互作用而发挥调控作用。根据目前的研究,约有10%的酿酒酵母基因转录受到Spt 蛋白的调控,且与环境压力下上调基因的调控密切相关。Spt 蛋白参与的庞大的调控网络及其复杂的调节机制是当前一个研究热点。Spt 蛋白还具有转座子抑制的功能,是转座子功能调控和适应性进化意义上的重要“开关”。除此之外,一些Spt 蛋白可以直接调控不饱和脂肪酸的合成,从而直接影响细胞膜重塑,对于酵母广泛抗性具有重要意义。文中从以上3 个维度对迄今为止Spt 蛋白的研究进展进行综述,结合前期研究工作,对于Spt 蛋白通过转录调控、细胞膜转变...
zh-cn
pair_29893074
Oligonucleotides are widely used as effective tools to regulate gene expression and drugs for targeted gene therapy. Therefore, they are potentially useful for the treatment of viral, tumor and hereditary diseases. Therapeutic oligonucleotides include antisense oligonucleotide, small interference RNA (siRNA), Ribozyme,...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
寡核苷酸是生物医学和生命科学研究中调节基因表达的基本工具,并被开发为基因靶向治疗药物,用于治疗病毒、肿瘤和遗传病。寡核苷酸药物主要包括反义寡核苷酸、小干扰RNA、核酶、脱氧核酶、反基因、CpG寡核苷酸、转录因子诱饵和核酸适配体等。天然的寡核苷酸在体内很容易被降解,特异性低,且有毒副作用。因此,药物寡核苷酸通常带有特定的修饰基团,如硫代磷酸二酯键、氟代、甲基以及锁核酸等,以增强寡核苷酸在体内的稳定性,提高特异性,并降低其毒副作用。目前,寡核苷酸主要采用化学方法合成,但化学合成的寡核苷酸初产物纯度低,而纯化十分困难。大规模核酸合成仪和纯化设备十分昂贵,因而大量合成和纯化寡核苷酸的成本高昂,大大限制了寡核苷酸药物的研究和应用。尽管已经涌现...
zh-cn
pair_29893075
The aim of this study is to quantify the 146S antigen in foot-and-mouth disease virus (FMDV) inactivated vaccine by size-exclusion chromatography (SEC). The analysis was performed on a TSKgel G4000SWXL column (7.8 mm×30 cm), with a pH 7.2 buffer salt system as the mobile phase. The flow rate was 0.6 mL/min, the injecti...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
旨在应用体积排阻色谱法测定口蹄疫灭活疫苗中的146S 抗原含量。使用TSKgel G4000SWXL (7.8 mm×30 cm)色谱柱,以pH 7.2 的缓冲盐体系作为流动相,流速为0.6 mL/min,进样量为100 μL,检测波长为259 nm。以口蹄疫病毒 (O 型) 灭活146S 抗原纯化样品建立标准曲线;使用灭活抗原液配制3 份口蹄疫灭活疫苗,并进行精密度、重复性、特异性、耐受性验证;应用该方法快速测定16 批疫苗的146S 含量。结果表明,抗原浓度在0.56–67.42 μg/mL范围内,其峰面积与浓度的线性关系良好 (R2=0.996,n=10),3 份疫苗146S 抗原测定回收率分别为93.6% (RSD=2.7%...
zh-cn
pair_29893076
We aimed to obtain the recombinant aminopeptidase encoded by Listeria monocytogenes (L. monocytogenes) gene lmo1711, and characterized the enzyme. First, the amino acid sequences of Lmo1711 from L. monocytogenes EGD-e and its homologues in other microbial species were aligned and the putative active sites were analyzed...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
对单核细胞增多性李斯特菌 (简称单增李斯特菌) lmo1711 基因编码的氨基肽酶进行克隆表达与纯化,并研究该重组蛋白的体外酶学特性。首先通过生物信息学分析预测Lmo1711 与氨基肽酶家族成员的亲缘关系及关键活性位点的保守性。利用SWISS-MODEL 模拟预测该蛋白的空间结构;构建Lmo1711 原核表达载体并转化入E. coli Rosetta 中,诱导表达重组目的蛋白,并利用镍离子亲和层析方法纯化目的蛋白;以氨基酸-对硝基苯胺偶联物为底物,Lmo1711 通过水解底物N 端氨基酸残基产生游离对硝基苯胺单体,405 nm 处检测吸光值对该产物进行检测从而分析Lmo1711 的酶学特性。在此基础上系统研究Lmo1711 对不同氨...
zh-cn
pair_29893077
To study the immunogenicity of EsxA protein of Staphylococcus aureus, the EsxA-pET-28a recombinant plasmid was constructed and the expression product was analyzed by SDS-PAGE and Western blotting after the positive recombinant plasmid was induced by IPTG. Mice were immunized with purified EsxA protein and then the IgG,...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
为分析牛乳源金黄色葡萄球菌 (Staphylococcus aureus) EsxA 蛋白的免疫原性,构建EsxA-pET-28a 重组表达质粒,重组质粒经诱导表达后进行SDS-PAGE 和Western blotting 鉴定。用纯化后重组EsxA 蛋白免疫小鼠,用间接ELISA 检测免疫小鼠血清中的IgG、IgG1 和IgG2a 水平;免疫小鼠经S. aureus 菌株攻击后,检测小鼠肝、脾、肾组织荷菌数和免疫保护率,观察S. aureus 菌株攻击后小鼠肝、脾、肾病理组织学变化。结果表明,成功诱导表达了EsxA 重组蛋白,该重组蛋白免疫小鼠后血清抗体效价可达1∶900,与对照相比,重组蛋白免疫后可减少小鼠肝、脾、肾组织的荷菌数...
zh-cn
pair_29893078
Carotenoids are a class of terpenes of commercial interest and exert important biological functions. Engineering morphological and biosynthetic aspects of Escherichia coli cell membrane could improve its storage capacity for β-carotene. However, how the synthesis of phosphatidylethanolamine, the major component of the ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
β-胡萝卜素是类胡萝卜素家族中的典型代表,属于疏水性较强的化合物,前期研究表明,改变细胞膜形态以及增加3-磷酸甘油二酯的供给,均可容纳更多的β-胡萝卜素,从而提高其产量。然而在之前的研究中,没有对细胞膜的磷脂中主要组分磷脂酰乙醇胺的合成途径对β-胡萝卜素积累的影响进行系统的讨论。本研究将磷脂酰乙醇胺的合成途径分为上中下游3 个模块,对它们的多种表达组合策略进行比较。首先过表达了上游模块1,菌株CAR016的β-胡萝卜素的产量与单位细胞的β-胡萝卜素产量均有显著提高,分别可达到44 mg/L 以及13.7 mg/g DCW。与对照菌株相比,分别提高30.5%与35.6%。过表达磷脂酰乙醇胺合成的中游模块,β-胡萝卜素的产量以及单位细胞...
zh-cn
pair_29893079
Pichia pastoris is a versatile protein expression system. At present, the expression plasmids are integrated plasmids whereas the episomal plasmids are rarely used. In this study, the autonomously replicating sequence derived from yeast itself was ligated into the integrative expression vector pGAP to generate an auton...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
巴斯德毕赤酵母是用途广泛的蛋白表达系统。目前用于毕赤酵母的质粒主要以整合型质粒为主,很少见到游离的质粒用于外源基因的表达。文中通过将来源于酵母自身的自主复制序列连接到酵母整合型表达载体pGAP 中构成自主复制的游离型表达载体pGAPZαA-PARS,将该载体用于表达木聚糖酶基因。转化毕赤酵母后同传统的整合型表达菌株相比,以甘油为碳源时最高酶活达到343 U/mL,比整合型表达提高了45.9%。同时游离载体表达重组酶比活相对整合表达提高了81.2%。为了节约发酵成本,进一步研究了分别以甘油、葡萄糖、蔗糖、混合碳源 (蔗糖︰甘油=1︰2) 等不同碳源下游离型重组菌株的表达水平。发现甘油表达水平最高,蔗糖最低,但是以工业葡萄糖为碳源时产酶...
zh-cn
pair_29893080
Perillyl alcohol, [4-isopropylene-1-cyclohexene] methanol, is a monocyclic monoterpene alcohol with special odorous similar to that of linalool and terpineol. It has application potential in pharmaceutical, daily chemical and food industries. In this study, one method for the synthesis of perillyl alcohol through the M...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
紫苏醇,即[4-异丙烯基-1-环己烯]甲醇,是一种具有类似芳樟醇和松油醇特殊气味的单环单萜烯醇。在医药、食品和化妆品等行业具有广阔市场空间和研究价值。文中研究了以工程大肠杆菌通过甲羟戊酸途径合成紫苏醇的方法。首先在大肠杆菌中构建来源于粪肠球菌的MVA代谢途径合成柠檬烯,随后柠檬烯通过细胞色素P450烷烃羟化酶的羟基化转化为紫苏醇。然后将构建的紫苏醇合成菌株在摇瓶发酵条件下进行优化,研究发现工程大肠杆菌以葡萄糖为原料,通过MVA 代谢途径可合成约50.12 mg/L 的紫苏醇。本研究构建合成紫苏醇的MVA 代谢途径也可用于其他萜类化合物的合成,为今后生物法合成萜类化合物提供了理论依据和技术支持。.
zh-cn
pair_29893081
CAR-T cell therapy that targets surface antigens to kill tumor cells specifically has recently become another cornerstone in tumor immunotherapy. In this study, a lentiviral expression plasmid of CAR targeting human epidermal growth factor receptor 2 (HER2) was constructed by genetic engineering. The recombinant plasmi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
CAR-T 细胞疗法通过靶向识别肿瘤细胞表面抗原,特异性杀伤肿瘤细胞,近年来已经成为肿瘤免疫疗法的研究热点。通过基因工程方法构建靶向人类表皮生长因子受体2 (HER2) 的CAR 慢病毒表达质粒,以磷酸钙沉淀辅助多质粒共转染HEK293T 细胞包装,制备CAR 慢病毒颗粒lenti-car,感染人外周血单核细胞获得HER2靶向的CAR-T 细胞,并分析其对HER2 阳性和阴性肿瘤细胞的特异性抑制效果。研究结果表明,构建的CAR-T细胞可被HER-2 阳性的肿瘤细胞特异性激活,分泌大量炎症性细胞因子IFN-γ 和IL-2。在同样效靶比等处理条件下,构建的HER2 靶向CAR-T 细胞对HER2 阳性的人卵巢癌细胞株SK-OV-3 的生...
zh-cn
pair_29893082
To develop and evaluate an ELISA kit for Anti-PLA2R IgG. Recombinant M-type phospholipase A2 receptor (PLA2R) protein expressed in HEK293 was taken as coating antigen, HRP-labeled rabbit anti-human IgG was taken as a tracer, to test the anti-PLA2R IgG on the basis of the principle of ELISA. The detection linear range, ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
旨在自制能够辅助诊断原发性膜性肾病的抗磷脂酶A2 受体 (PLA2R) 抗体酶联免疫吸附试验 (ELISA)定量检测试剂盒;通过包埋HEK293 细胞表达的重组抗原、患者血清与抗原反应、酶的催化放大效应测定样本中抗PLA2RIgG 滴度,通过临床数据分析、与市售试剂盒的比对,评价该试剂盒的临床应用价值及性能。研究发现自制试剂盒与国外试剂盒检测阳性一致率97.2%,阴性一致率100%;检测限不高于2 RU/mL;准确度的测量相对偏差在±15%区间内;试剂盒线性范围在2–500 RU/mL,线性相关系数r 值不低于0.990 0;重复性检测的变异系数 (CV) 小于15%;于37 ℃恒温箱放置1 周后,2–8 ℃放置1 年后,检测性能无...
zh-cn
pair_29893085
In this study, we established a rapid and efficient HPLC method to determine the accumulation of Huperzine A and Huperzine B in the fermentation broth of endophytic fungus Colletotrichum gloesporioides from Huperzia serrate. The chloroform extracts of fermentation broth were dissolved in methanol and filtered before in...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
建立了高效液相色谱 (HPLC) 测定蛇足石杉 (Huperzia serrate) 内生真菌胶胞炭疽发酵液中石杉碱甲 (Huperzina A) 和石杉碱乙 (Huperzine B) 含量的方法,并以此方法检测胶胞炭疽发酵液中石杉碱甲和石杉碱乙含量的积累。内生真菌发酵液经氯仿萃取、甲醇溶解、过滤后进行高效液相检测分析,选用Agilent Eclipse plus-C18 色谱柱 (250 mm×4.6 mm, 5 μm),以0.015 mol/L乙酸铵 (pH 6.8) 和甲醇溶液 (70∶30) 为流动相进行等度洗脱,流速1 mL/min,检测波长为308 nm,连续检测内生真菌胶胞炭疽发酵液中第6–15天石杉碱甲和石杉碱乙的...
zh-cn
pair_29893086
An in vitro synthesized random ssDNA library was subjected to 12 rounds of selection against anti-screening cells and sieving cells by SELEX. Normal and inflammatory cervical exfoliation cells were selected as anti-screening cells, and the cervical exfoliation cells of low-grade squamous intraepithelial lesion (CIN1), ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
构建随机ssDNA 文库,通过SELEX 技术,以正常、炎性宫颈脱落细胞为反筛细胞,以上皮内低级别病变 (CIN1)、上皮内高级别病变 (CIN2、CIN3) 和鳞状细胞癌脱落细胞为正筛细胞,经过12 轮筛选特异性适配子高度富集得到宫颈癌前病变适配子库,经特异性、亲和力分析和细胞免疫荧光确立高特异性适配子CIN-Ap4 可作为诊断宫颈癌前病变生物标志物,为宫颈癌前病变分子诊断奠定理论基础,提供新思路。利用Prime Premier 5.0设计构建了随机ssDNA 文库并根据文库两端固定序列设计引物,对对称PCR 和间接不对称PCR 中的退火温度、循环数以及上、下游引物浓度比等条件进行优化,分析确定50 μL 反应体系中对称PCR 的...
zh-cn
pair_29893087
Pyrroloquinoline quinone (PQQ) is a bacterial dehydrogenase coenzyme. PQQ can promote body growth and regulate the function of free radical level of the body. It could be applied in food, medicine and other fields. Due to the extremely high cost of chemical synthesis, the production of PQQ by microbial fermentation att...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
None
zh-cn
pair_29893088
As a platform chemical, acetoin has a great potential of application in medicine and food industries. In order to improve the efficiency of acetoin production, Bacillus amyloliquefaciens was treated by atmospheric and room temperature plasma and gamma rays. Two-round screening was adopted for obtaining positive mutants...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
3-羟基丁酮 (Acetoin) 作为一种重要的食用香料和平台化合物被广泛应用于医药、食品等领域。为改善解淀粉芽孢杆菌Bacillus amyloliquefaciens 的3-羟基丁酮生产能力,采用常压室温等离子体 (ARTP) 和⁶⁰Co γ 射线进行复合诱变,以3-羟基丁酮产量为分析指标,筛选获得最优突变株B. amyloliquefaciens H-5,3-羟基丁酮产量为68.2 g/L。为进一步实现3-羟基丁酮的高效生产,对此突变株进行5 L 发酵罐水平的培养条件优化,并于30 L发酵罐上进行放大培养,最终3-羟基丁酮产量达85.2 g/L,较出发菌株B. amyloliquefaciens FMME088 提高了26.8...
zh-cn
pair_29895113
Ocular chemical burns are common and serious ocular emergencies which require immediate and intensive evaluation and treatment. Loss of vision and disfigurement affect the victims, bringing great sufferings to themselves and their families. China is the biggest developing country in the world with a large number of suc...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
眼化学烧伤是需要紧急处理、评估和治疗的眼科急症,是我国常见眼部疾患。眼化学烧伤可造成视力丧失和毁容等,给患者及其家庭带来极大痛苦,因此需要从不同层面采取各种措施加以预防,而一旦发生须将损伤程度降至最低。本文从转变眼化学烧伤的治疗观念、关注眼化学烧伤分级及与预后关系的变化、提高我国眼化学烧伤的预防水平、积极应对眼化学烧伤救治中的问题和挑战4个方面进行阐述,以期为进一步提高我国眼化学烧伤的防治水平指明方向、提供参考。(中华眼科杂志,<i>2018</i>,<i>54</i>:401-405).
zh-cn
pair_29895114
Dry eye has become the most common ocular surface disease in China's clinical ophthalmology. However, dry eye in children has not achieved enough attention. It lacks related information of basic data and diagnostic criteria, and there is no standard for the clinical diagnosis and treatment. As dry eye in children has i...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
干眼已成为我国眼科临床最常见的眼表疾病,而儿童干眼的诊断和治疗并未受到足够关注,缺乏相关的基础数据和诊断标准,临床诊断和治疗不规范现象明显。儿童干眼有其自身的特点,因而诊断和治疗应与成人不完全相同。近年来电子产品的普及和广泛应用,加上部分全身性因素,导致儿童干眼的发病人数呈快速上升趋势。本文以儿童干眼诊断和治疗现状为背景,从儿童干眼临床诊断和治疗面临的困难入手,提出大力加强儿童干眼的研究,拓展基础研究,建立相关基础数据,提高我国儿童干眼临床诊断和治疗的水平。(中华眼科杂志,<i>2018</i>,<i>54</i>:<i>406</i>-<i>408</i>).
zh-cn
pair_29895121
Diabetic keratopathy is a common ocular complication of patients with a long-term history of diabetes and it will have a negative effect on the visual quality and function. A study reported that the incidence of diabetic keratopathy in diabetic patients ranged from 47% to 64%, but the precise underlying pathogenesis re...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
糖尿病角膜病变是常见的糖尿病眼部并发症之一,47%~64%患者在糖尿病病程中会出现该眼部疾患,严重影响患者的视觉质量和视功能。目前发病机制尚不完全明确。大量研究结果证实晚期糖基化终末产物(AGEs)是引起糖尿病慢性并发症的重要因素之一,同时AGEs参与糖尿病高血糖记忆效应的发生。本文就AGEs与糖尿病角膜病变的研究现状及研究前景进行总结和分析,以期为临床进行相关研究提供参考。(中华眼科杂志,<i>2018</i>,<i>54</i>:<i>475</i>-<i>480</i>).
zh-cn
pair_29897622
Although numerous studies have indicated the significance of parental support and parent-child communication in alleviating the adverse effects of parental departure on left-behind children, researchers have rarely addressed the impact of parent education on migrant parents. On the basis of the results of a pilot rando...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
虽然很多研究都表明家长支持和家长-儿童沟通对于缓解家长离开对于留守儿童不利影响的意义,研究者们很少涉及家长教育对于移民家长的影响。基于一个随机控制试点试验结果,该研究涉及考察一个针对中国留守儿童由农村迁居到城市的移民母亲的家长教育项目可能的结果和可行性。基于针对家长教育的存在-叙事方法,该项目由6个2.5小时环节构成。样本包括56个从中国深圳社会服务中心应召来的移民母亲构成。这些母亲被随机分配到即时组(n = 28, M = 34.82 年, SD = 4.12, 年龄在23到43岁之间)或候补控制组(n = 28, M = 34.68 年, SD = 4.53, 年龄在28到43岁之间)。实验有两个假设:项目会正面影响参与者的家长...
zh-cn
pair_29897622
Although numerous studies have indicated the significance of parental support and parent-child communication in alleviating the adverse effects of parental departure on left-behind children, researchers have rarely addressed the impact of parent education on migrant parents. On the basis of the results of a pilot rando...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Aunque numerosos estudios han indicado la importancia del apoyo de los padres y de la comunicación entre los padres y los hijos a la hora de aliviar los efectos desfavorables de la partida de los padres en los niños que estos dejan en las zonas rurales, los investigadores rara vez han abordado la influencia que tiene l...
es
pair_29902858
Congenital ear deformities are common diseases in infants and can be effectively corrected by ear molding. However, the current knowledge about the auricular othosis is still insufficiency. As the new type of ear correction system has been produced, non-surgical correction of ear deformities is increasingly popular. To...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
先天性耳廓畸形发生率高,耳廓矫形器对新生儿耳廓畸形治疗效果确切,但目前认知不足,推广有限。近年随着新一代小儿耳廓矫形器的引入,非手术矫正新生儿耳廓畸形逐渐受到重视。为规范该类技术在临床中的应用,提高治疗成功率,本文根据国内外文献资料总结先天性耳廓畸形的类别、发生率、自愈率和发病机制,并对耳廓矫形器的材料、治疗时机、有效率以及并发症的发生和处理进行归纳,以期指导临床更好地开展该类技术,促进其推广应用。.
zh-cn
pair_29902859
Stem cell is critical to regeneration of tissue or organ of human. How to promote repair or regeneration in the tissues/organ using its pluripotency is always an important issue. Lgr5-possitive cell is one type of the stem cell-like cells capable of pluripotent differentiation in various tissues/organs of both humans a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
干细胞是人体中组织器官再生的基石,如何充分利用其多能性促进机体细胞、组织和器官的修复或再生是生物医学研究中长久以来的热点和重点。Lgr5阳性细胞是机体中具有多能性分化能力的干细胞样细胞之一,存在于小鼠或人类的多种器官或组织中。目前研究表明,单个或少量的Lgr5阳性干细胞可以在3D培养体系中生长形成多种类器官(organoid),这些类器官的某些生物学及生理学特性与其来源的器官类似或一致。这些实验拓宽了研究者的视野,同时也开辟了一种新的干细胞研究方向。对于内耳细胞再生研究来说,Lgr5阳性内耳干细胞正是近年来刚被证实的内耳多能性细胞群。如何从来源于Lgr5阳性干细胞的类器官研究中获得灵感或经验,对于内耳干细胞的研究具有前瞻性指导意义。...
zh-cn
pair_29902860
Recurrent laryngeal nerve (RLN) injury is a serious complication of thyroidectomy. Intraoperative neuro-monitoring(IONM) is a technology for identifying the integrity of nerves during operation by electrophysiological means, which included the intermitted IONM and the continuous IONM.This paper aims to compare the supe...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
喉返神经损伤是甲状腺手术严重并发症。术中喉返神经监测技术应用电生理技术监测喉返神经的功能完整性,主要包括间断性术中监测和持续术中神经监测2种技术,两者各有利弊。本文对此2种技术在甲状腺手术中喉返神经保护的研究现状及进展进行综述。.
zh-cn
pair_29902942
Women during perimenopausal period experience a range of symptoms, which interfere with physical, sexual, and social life. About 65-75% of symptoms connected with postmenopausal period are vasomotor symptoms (VMS), such as hot flushes and night sweats. Hot flushes are subjective sensation of heat associated with cutane...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
摘要 围绝经期的妇女会出现一系列症状, 这些症状会干扰身体, 性生活和社交。绝经期间约65-75%的症状是血管舒缩症状(VMS), 如潮热和盗汗。潮热是与皮肤血管舒张和核心温度下降相关的主观热感。VMS被怀疑与促性腺激素释放激素(GnRH)脉冲式释放过多和随后的黄体生成素(LH)分泌密切相关。同时研究显示, 卵巢中合成的类固醇激素缺乏负反馈导致位于漏斗核中的肥大Kisspeptin /神经激肽B /强啡肽(KNDy)神经元过度活化。 Kisspeptin(KISS1)和神经激肽B(NKB)的过度分泌以及强啡肽的下调在GnRH脉冲的产生中起主导作用, 反之导致VMS的发生。给予NK3受体特异性激动剂, 高效选择性NK3R激动剂导致绝经...
zh-cn
pair_29904220
To raise awareness about the importance of public pharmaceutical standards, identify if and, if so, where current pharmacopeias are falling short in the development of new and complete monographs and foster collaboration among the various pharmacopeias, to prioritize, develop and make available standards for those key ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
旨在提高人们对公共药物标准重要性的意识,明确现有药典是否落后于最新完整专著的发展。如落后,明确具体落后在哪些方面,并促进不同药典之间的合作,从而优先考虑发展没有完整专著的关键药物,并为其制定标准。. 2017 年 8 月,我们采纳了八部药典以明确第 20 版世界卫生组织《基本药物示范目录》 669 种药品中的哪些药物涵盖在完整或不完整专著中。我们纳入的药典包括《巴西药典》、《英国药典》、印度药典委员会出版的《印度药典》、《国际药典》、《日本药典》、《墨西哥药典》、《中华人民共和国药典》和《美国药典》。. 在研究的八部药典中,共有 99 (15%) 种列于《基本药物示范目录》中的药物尚无专著。目录中的心血管药物只列出了 3% (1/3...
zh-cn
pair_29904220
To raise awareness about the importance of public pharmaceutical standards, identify if and, if so, where current pharmacopeias are falling short in the development of new and complete monographs and foster collaboration among the various pharmacopeias, to prioritize, develop and make available standards for those key ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Sensibiliser à l'importance des normes pharmaceutiques publiques, déterminer si certaines pharmacopées actuelles présentent des lacunes concernant l'élaboration de nouvelles monographies complètes et, si tel est le cas, lesquelles, et encourager la collaboration entre les différentes pharmacopées pour hiérarchiser, éla...
fr
pair_29904220
To raise awareness about the importance of public pharmaceutical standards, identify if and, if so, where current pharmacopeias are falling short in the development of new and complete monographs and foster collaboration among the various pharmacopeias, to prioritize, develop and make available standards for those key ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Concienciar sobre la importancia de los estándares farmacéuticos públicos, identificar si, y, si es así, las farmacopeas actuales no son suficientes para el desarrollo de monografías nuevas y completas y fomentar la colaboración entre las distintas farmacopeas, para priorizar, desarrollar y poner a disposición estándar...
es
pair_29904220
To raise awareness about the importance of public pharmaceutical standards, identify if and, if so, where current pharmacopeias are falling short in the development of new and complete monographs and foster collaboration among the various pharmacopeias, to prioritize, develop and make available standards for those key ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Повысить осведомленность о важности государственных фармацевтических стандартов, определить, где текущие фармакопеи не справляются с разработкой новых и полных монографий, и способствовать сотрудничеству между различными фармакопеями, чтобы определить приоритеты, разработать и предоставить доступные стандарты для ключе...
ru
pair_29904221
To develop and test a simple system for recording and reporting the diagnosis and treatment of latent tuberculosis infection and to compare the effects of passive and active tracing of child contacts on indicators of such infection. We revised Burkina Faso's latent tuberculosis infection register and quarterly tubercul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
研发并测试一个简易系统,用于记录和报告潜在结核病感染的诊断与治疗,并对此类感染指标下针对儿童接触者分别进行被动追踪和主动追踪的效果进行比较。. 我们修订了布基纳法索潜在结核病感染登记和季度结核病申报表。随后,在 2016 年 4 月 1 日至 2017 年 3 月 31 日之间,针对年龄不足 5 岁的活动性结核病患者进行常规性筛查并对此类符合条件的接触者开始实施预防性治疗,分别测量其在全国范围内的覆盖率和相应的百分比。2016 年,我们先评估了上盆地大区潜在结核病感染指标,之后,社区健康工作者开始积极追踪年龄不足 5 岁的儿童接触者。. 在我们研究期间,经过常规性筛查和被动接触追踪,据报告称,布基纳法索有 3717 例结核病案例和 ...
zh-cn
pair_29904221
To develop and test a simple system for recording and reporting the diagnosis and treatment of latent tuberculosis infection and to compare the effects of passive and active tracing of child contacts on indicators of such infection. We revised Burkina Faso's latent tuberculosis infection register and quarterly tubercul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Élaborer et tester un système simple pour enregistrer et déclarer le diagnostic et le traitement des cas d'infection tuberculeuse latente et comparer les effets de la recherche passive et active des contacts enfants sur les indicateurs de cette infection. Nous avons passé en revue le registre des infections tuberculeus...
fr
pair_29904221
To develop and test a simple system for recording and reporting the diagnosis and treatment of latent tuberculosis infection and to compare the effects of passive and active tracing of child contacts on indicators of such infection. We revised Burkina Faso's latent tuberculosis infection register and quarterly tubercul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Desarrollar y probar un sistema simple de registro y presentación de informes sobre el diagnóstico y el tratamiento de la infección tuberculosa latente y comparar los efectos del seguimiento pasivo y activo de los contactos infantiles con indicadores de dicha infección. Se revisó el registro de infección tuberculosa la...
es
pair_29904221
To develop and test a simple system for recording and reporting the diagnosis and treatment of latent tuberculosis infection and to compare the effects of passive and active tracing of child contacts on indicators of such infection. We revised Burkina Faso's latent tuberculosis infection register and quarterly tubercul...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Разработать и протестировать простую систему регистрации и отчетности для диагностики и лечения латентной туберкулезной инфекции и сравнить влияние пассивного и активного отслеживания детей, находившихся в контакте с инфицированным человеком, на показатели такой инфекции. Авторы изучили реестр лиц, больных латентным ту...
ru
pair_29904222
To develop and test a method that allows an objective assessment of the value of any health policy in multiple domains. We developed a method to assist decision-makers with constrained resources and insufficient knowledge about a society's preferences to choose between policies with unequal, and at times opposing, effe...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
开发并测试一种可客观评估多领域任意卫生政策价值的方法。. 我们开发了一种方法,在资源有限且对社会偏好缺乏足够了解的情况下,协助决策者在对多个结果有不平等(时而相反)效果的政策间做出选择。我们的方法拓展了标准的数据包络分析以解决卫生政策的现实问题,例如产生多种相反结果、缺乏针对这些结果的群体偏好信息。我们对标准分析作了 4 次修改:(i) 将政策本身视为分析对象;(ii) 可采用该方法为政策排序;(iii) 任何结果既可作为输出信息,又可作为输入信息;和 (iv) 可测量浮动回报。我们采用之前发布的三种低收入国家卫生政策分析来测试该方法。. 我们的新方法用于先前分析时,比传统成本效益分析和标准数据包络分析的效果更好。调整后的分析可从任...
zh-cn
pair_29904222
To develop and test a method that allows an objective assessment of the value of any health policy in multiple domains. We developed a method to assist decision-makers with constrained resources and insufficient knowledge about a society's preferences to choose between policies with unequal, and at times opposing, effe...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Développer et tester une méthode permettant d'évaluer objectivement la valeur de toute politique sanitaire dans de multiples domaines. Nous avons développé une méthode pour aider les décideurs qui possèdent des ressources limitées et des connaissances insuffisantes concernant les préférences d'une société à choisir ent...
fr
pair_29904222
To develop and test a method that allows an objective assessment of the value of any health policy in multiple domains. We developed a method to assist decision-makers with constrained resources and insufficient knowledge about a society's preferences to choose between policies with unequal, and at times opposing, effe...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Desarrollar y probar un método que permita una evaluación objetiva del valor de cualquier política de salud en múltiples dominios. Se desarrolló un método para ayudar a los responsables de la toma de decisiones con recursos limitados y conocimientos insuficientes sobre las preferencias de una sociedad para elegir entre...
es
pair_29904222
To develop and test a method that allows an objective assessment of the value of any health policy in multiple domains. We developed a method to assist decision-makers with constrained resources and insufficient knowledge about a society's preferences to choose between policies with unequal, and at times opposing, effe...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Разработать и протестировать метод, который позволил бы объективно оценивать значение любой политики в различных сферах деятельности в области здравоохранения. Авторы разработали метод, содействующий принятию решений при выборе между политиками с неравными и порой противоположными последствиями уполномоченными лицами в...
ru
pair_29904224
Kidney disease has been described as the most neglected chronic disease. Reliable estimates of the global burden of kidney disease require more population-based studies, but specific risks occur across the socioeconomic spectrum from poverty to affluence, from malnutrition to obesity, in agrarian to post-industrial set...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
肾病被视为全球最被忽视的慢性疾病。全球肾病负担的可靠预估需要更多基于人群的研究,但是特定风险的发生横跨社会各经济范围,从贫困到富裕,从营养不良到肥胖,从农耕时代到后工业时代,生命周期从新生儿到老年人。肾脏并发症导致一系列可传染和不可传染的疾病,许多患有肾病的人缺乏治疗途径。肾病的成因、结果和成本对所有国家的公众健康政策都有影响。肾病的风险也受种族、性别、地点和生活方式的影响。日益扩大的经济健康差距、移民、人口转型、不安全的工作条件和环境威胁、自然灾害与污染可能会阻碍试图降低肾病发病率和死亡率的努力。解决全球肾病负担需要多部门合作。可持续发展目标强调多部门合作解决健康问题的重要性。我们列出达成可持续发展目标所采取的措施,这些措施有提升...
zh-cn
pair_29904224
Kidney disease has been described as the most neglected chronic disease. Reliable estimates of the global burden of kidney disease require more population-based studies, but specific risks occur across the socioeconomic spectrum from poverty to affluence, from malnutrition to obesity, in agrarian to post-industrial set...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La maladie rénale est décrite comme la maladie chronique la plus négligée. Si d'autres études en population sont nécessaires pour établir des estimations fiables de la charge mondiale de la maladie rénale, les risques spécifiques sont présents dans l'ensemble du spectre socioéconomique, à la fois en situation de pauvre...
fr
pair_29904224
Kidney disease has been described as the most neglected chronic disease. Reliable estimates of the global burden of kidney disease require more population-based studies, but specific risks occur across the socioeconomic spectrum from poverty to affluence, from malnutrition to obesity, in agrarian to post-industrial set...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La insuficiencia renal se ha descrito como la enfermedad crónica más olvidada. Serían necesarios más estudios basados en la población para obtener estimaciones fiables de la carga mundial de la insuficiencia renal, pero existen riesgos específicos en todo el espectro socioeconómico desde la pobreza hasta la prosperidad...
es
pair_29904224
Kidney disease has been described as the most neglected chronic disease. Reliable estimates of the global burden of kidney disease require more population-based studies, but specific risks occur across the socioeconomic spectrum from poverty to affluence, from malnutrition to obesity, in agrarian to post-industrial set...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Хроническая болезнь почек известна как одно из тех хронических заболеваний, которым уделяется меньше всего внимания. Надежные оценки глобального бремени хронической болезни почек требуют проведения исследований, более ориентированных на популяционный уровень, но определенные риски возникают во всем социально-экономичес...
ru
pair_29904223
To conduct a systematic review to estimate the prevalence of asymptomatic Zika virus infection in the general population and in specific population groups. We searched PubMed®, Embase® and LILACS online databases from inception to 26 January 2018. We included observational epidemiological studies where laboratory testi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
对一般人群和特定人群中无症状寨卡病毒感染的患病率进行系统评审。. 自 2018 年 1 月 26 日起,我们检索了 PubMed®、Embase® 和 LILACS 的在线数据库。我们纳入观察性流行病学研究,使用实验室测试确认参与者接触寨卡病毒的测试结果为阳性并且还记录了塞卡病毒症状状态。我们排除将塞卡病毒症状作为纳入标准的研究。主要评估结果是所有无症状的塞卡病毒阳性参与者的百分比。我们使用质量效应方法和双反正弦变换进行元分析。. 我们评估了 753 项研究,其中 23 项被纳入元分析,共计 11305 位塞卡病毒阳性参与者。研究中的高度异质性 (<i>I<sup>2</sup></i>  = 99%) 表明,无症状塞卡病毒阳性参与...
zh-cn
pair_29904223
To conduct a systematic review to estimate the prevalence of asymptomatic Zika virus infection in the general population and in specific population groups. We searched PubMed®, Embase® and LILACS online databases from inception to 26 January 2018. We included observational epidemiological studies where laboratory testi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Réaliser une revue systématique afin d'estimer la prévalence des infections à virus Zika asymptomatiques dans la population générale et dans des groupes de population spécifiques. Nous avons fait des recherches en ligne dans PubMed®, Embase® et LILACS afin de trouver des références parues depuis la date de création de ...
fr
pair_29904223
To conduct a systematic review to estimate the prevalence of asymptomatic Zika virus infection in the general population and in specific population groups. We searched PubMed®, Embase® and LILACS online databases from inception to 26 January 2018. We included observational epidemiological studies where laboratory testi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Llevar a cabo una revisión sistemática para estimar la prevalencia de una infección asintomática del virus de Zika en la población general y en grupos de población específicos. Se realizaron búsquedas en las bases de datos en línea de PubMed®, Embase® y LILACS desde el origen hasta el 26 de enero de 2018. Se incluyeron...
es
pair_29904223
To conduct a systematic review to estimate the prevalence of asymptomatic Zika virus infection in the general population and in specific population groups. We searched PubMed®, Embase® and LILACS online databases from inception to 26 January 2018. We included observational epidemiological studies where laboratory testi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Провести систематический обзор для оценки распространенности бессимптомной инфекции, вызываемой вирусом Зика, в общей популяции и в определенных группах населения. Авторы провели поиск в онлайн-базах данных PubMed®, Embase® и LILACS с момента их создания до 26 января 2018 года. В обзор были включены наблюдательные эпид...
ru
pair_29904225
The burden of trauma and injuries in Uganda is substantial and growing. Two important gaps that need addressing are the shortage of trained people and a lack of national data on noncommunicable diseases and their risk factors in Uganda. We developed and implemented a new track within an existing master of public health...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
乌干达的创伤和伤害负担巨大且仍在不断增加。乌干达有两个严峻的问题亟需解决,一是缺乏训练有素的人员,二是缺乏国家层面上关于非传染性疾病及其风险因素的数据资料。. 我们在现有的公共健康硕士项目中开发并设置了一个新的分支,旨在培养达到硕士级别能力的人才,并促进对创伤和伤害类国家重点优先医疗项目的研究。我们还向更广泛的受众提供培训机会,并成立了一个高水平的国家级伤害论坛,以促进国家对话,并解决创伤、伤害和残疾的负担。. 乌干达坎帕拉的马凯雷雷大学公共卫生学院与位于美国巴尔的摩的约翰·霍普金斯大学的布隆博格公共卫生学院合作,于 2012 年实施了一项针对乌干达的创伤、伤害和残疾的慢性后果的项目。. 2012 至 2017 年间,我们支持了四批...
zh-cn
pair_29904225
The burden of trauma and injuries in Uganda is substantial and growing. Two important gaps that need addressing are the shortage of trained people and a lack of national data on noncommunicable diseases and their risk factors in Uganda. We developed and implemented a new track within an existing master of public health...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La charge de morbidité liée aux traumatismes et aux blessures en Ouganda est importante et en augmentation. La pénurie de personnes formées et le manque de données nationales sur les maladies non transmissibles et leurs facteurs de risque en Ouganda constituent deux lacunes importantes qui doivent être comblées. Nous a...
fr
pair_29904225
The burden of trauma and injuries in Uganda is substantial and growing. Two important gaps that need addressing are the shortage of trained people and a lack of national data on noncommunicable diseases and their risk factors in Uganda. We developed and implemented a new track within an existing master of public health...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La carga de traumatismos y lesiones en Uganda es notable y sigue creciendo. Dos deficiencias importantes que deben abordarse son la escasez de personal formado y la falta de datos nacionales sobre las enfermedades no contagiosas y sus factores de riesgo en Uganda. Se ha desarrollado e implementado un nuevo curso dentro...
es
pair_29904225
The burden of trauma and injuries in Uganda is substantial and growing. Two important gaps that need addressing are the shortage of trained people and a lack of national data on noncommunicable diseases and their risk factors in Uganda. We developed and implemented a new track within an existing master of public health...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Уганда характеризуется значительным и растущим бременем травматизма. Две важные проблемы, требующие решения, — это нехватка квалифицированных специалистов и отсутствие национальных данных о неинфекционных заболеваниях и их факторах риска в Уганде. В рамках существующей программы магистратуры в области общественного здр...
ru
pair_29904226
With limited global supplies of oral cholera vaccine, countries need to identify priority areas for vaccination while longer-term solutions, such as water and sanitation infrastructure, are being developed. In 2017, Malawi integrated oral cholera vaccine into its national cholera control plan. The process started with ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
由于全球口服霍乱疫苗的供应有限,各国需要确定接种疫苗的优先区域,而长期的解决方案(例如饮水和卫生基础设施)尚在发展中。. 2017 年,马拉维将口服霍乱疫苗纳入其全国霍乱控制计划。进程开始于书面材料审查和对之前监控与风险因素数据的分析。在一次协商会议上,研究人员、全国健康与水资源官员和来自非政府组织与国际组织的代表评估了数据以及对当地流行病的认识,决定了口服霍乱疫苗的优先地区。最终阶段是非紧急用途下为全球口服霍乱疫苗储备申请做准备。. 马拉维收集了霍乱的年度数据,自 20 世纪 70 年代以来,绝大部分地区都汇报过至少一次病例。. 截至 2017 年 4 月,政府在 20 多个月内为 12 个地区提供 320 万支疫苗的申请被批准。...
zh-cn
pair_29904226
With limited global supplies of oral cholera vaccine, countries need to identify priority areas for vaccination while longer-term solutions, such as water and sanitation infrastructure, are being developed. In 2017, Malawi integrated oral cholera vaccine into its national cholera control plan. The process started with ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
En raison de stocks mondiaux réduits de vaccins anticholériques oraux, les pays doivent identifier les zones prioritaires en matière de vaccination tout en développant des solutions à plus long terme, telles que des infrastructures d'alimentation en eau et d'assainissement. En 2017, le Malawi a intégré la vaccination a...
fr
pair_29904226
With limited global supplies of oral cholera vaccine, countries need to identify priority areas for vaccination while longer-term solutions, such as water and sanitation infrastructure, are being developed. In 2017, Malawi integrated oral cholera vaccine into its national cholera control plan. The process started with ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Con suministros mundiales limitados de la vacuna oral contra el cólera, los países deben identificar las áreas prioritarias para la vacunación mientras se desarrollan soluciones a más largo plazo, como las infraestructuras de agua y el saneamiento. En 2017, Malawi integró la vacuna oral contra el cólera en su plan naci...
es
pair_29904226
With limited global supplies of oral cholera vaccine, countries need to identify priority areas for vaccination while longer-term solutions, such as water and sanitation infrastructure, are being developed. In 2017, Malawi integrated oral cholera vaccine into its national cholera control plan. The process started with ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
В условиях ограниченного глобального обеспечения пероральной вакциной против холеры странам необходимо определить приоритетные области для вакцинации одновременно с разработкой долгосрочных решений, таких как объекты инфраструктуры водоснабжения и санитарии. В 2017 году Малави включила пероральную вакцину против холеры...
ru
pair_29905039
Spinal cord injury (SCI), especially the complete SCI, usually results in complete paralysis below the level of the injury and seriously affects the patient's quality of life. SCI repair is still a worldwide medical problem. In the last twenty years, Professor DAI Jianwu and his team pioneered complete SCI model by rem...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
脊髓损伤修复迄今仍是世界性的医学难题。戴建武教授团队近 20 年来专注脊髓损伤再生修复研究,建立了哺乳动物脊髓大段缺损全横断损伤模型,包括啮齿类、犬及非人灵长类全横断脊髓损伤模型,并于 2015 年 1 月 16 日在国际上首先开展了神经再生胶原支架材料修复完全性脊髓损伤的临床研究。文章依据领域研究进展,分析了脊髓完全性损伤后运动功能恢复的 3 种可能机制:① 运动神经长轴突再生通过损伤区域;② 损伤区新生的神经元连接损伤的两个断端,形成连接;③ 前述两种机制都存在。大量不同动物全横断脊髓损伤模型及再生修复研究结果均表明,神经再生胶原支架移植治疗全横断脊髓损伤动物是通过引导内源神经元形成桥接改善运动功能。在不同脊髓损伤模型中,特别是...
zh-cn
pair_29905041
To research the biological characteristics of different generations of rabbit nucleus pulposus cells (NPCs) that were cultured with natural culture and subculture method. The thoracolumbar segments of New Zealand white rabbits (6-8 weeks old and weighing 1.5-2.5 kg) were obtained and nucleus pulposus were isolated from...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
通过兔髓核细胞(nucleus pulposus cells,NPCs)自然传代培养退变模型,观察不同代次 NPCs 生物学特性。. 取 6~8 周龄新西兰大白兔(体质量 1.5~2.5 kg)胸腰椎节段髓核组织,采用酶消化法获取原代 NPCs,计为 P0 代;胰蛋白酶消化法传代获取第 1~3 代 NPCs,依次计为 P1、P2、P3 代。倒置相差显微镜观察各代 NPCs 形态特征;膜联蛋白 Ⅴ/碘化丙啶双染流式细胞术检测细胞凋亡率;免疫细胞荧光染色法和 Western blot 检测各代 NPCs 的缺氧诱导因子 1α(hypoxia-inducible factor 1α,HIF-1α)、聚集蛋白多糖(Aggrecan)、Ⅱ 型...
zh-cn
pair_29905043
To evaluate the short-term effectiveness of percutaneous endoscopic lumbar discectomy (PELD) in treatment of buttock pain associated with lumbar disc herniation. Between June 2015 and May 2016, 36 patients with buttock pain associated with lumbar disc herniation were treated with PELD. Of 36 cases, 26 were male and 10 ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨经皮脊柱内窥镜治疗以臀部疼痛为主的腰椎间盘突出症的近期疗效。. 2015 年 6 月–2016 年 5 月,采用经皮脊柱内窥镜治疗以臀部疼痛为主的腰椎间盘突出症患者 36 例。男 26 例,女 10 例;年龄 18~76 岁,平均 35.6 岁。病程 3 个月~10 年,平均 14 个月。单纯臀部疼痛 2 例,臀部疼痛伴大腿疼痛 6 例,伴同侧下肢疼痛 28 例。单节段椎间盘突出 34 例(L <sub>4</sub><sub>、</sub><sub>5</sub> 15 例,L <sub>5</sub>、S <sub>1</sub> 19 例),L <sub>4</sub><sub>、</sub><sub>5</sub> 合并...
zh-cn
pair_29905044
To analyze the correlation between the polymorphism on interleukin 6 (IL-6) gene promoter region-174 locus and adolescent idiopathic scoliosis (AIS), including the susceptibility, the bracing effectiveness, and the possible mechanism. The 182 AIS patients and 210 healthy controls who met the inclusion criteria between ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨 IL-6 基因启动子区-174 位点多态性与青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)易感性、支具矫形疗效的相关性,分析其可能的机制。. 以 2013 年 1 月–2016 年 1 月收治并符合选择标准的 182 例 AIS 患者,以及同期体检的无脊柱异常青少年 210 例,作为研究对象。检测所有研究对象 IL-6 基因启动子区-174 位点基因型,血清 IL-6 水平,股骨颈及腰椎骨密度(bone mineral density,BMD),骨代谢参数骨碱性磷酸酶(bone alkaline phosphatase,BALP)、骨钙素(bone gla protein,BGP...
zh-cn
pair_29905045
To investigate the mid-term effectiveness of debridement with prosthesis retention for periprosthetic joint infection (PJI) after total hip arthroplasty (THA) and total knee arthroplasty (TKA), and analyze the influence factors that affected the effectiveness. A clinical data of 45 cases with PJI after THA (16 cases) a...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨应用保留假体清创术治疗人工全髋关节置换术(total hip arthroplasty,THA)及人工全膝关节置换术(total knee arthroplasty,TKA)后假体周围感染(periprosthetic joint infection,PJI)的中期疗效以及导致清创失败的危险因素。. 回顾分析 2011 年 1 月—2015 年 1 月,应用保留假体清创术治疗的 45 例 THA 及 TKA 后 PJI 患者临床资料。男 19 例,女 26 例;年龄 23~78 岁,平均 58.4 岁。THA 16 例,TKA 29 例。40 例为初次关节置换术后、5 例为翻修术后发生感染。关节置换或者翻修术至出现感染症状时间为...
zh-cn
pair_29905046
To explore the effectiveness of high strength suture fixation in treatment of patellar transverse fracture. Between June 2014 and June 2016, 38 patients with the patellar transverse fracture were treated with high strength suture internal fixation. There were 24 males and 14 females with the age of 26 to 64 years (mean...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨高强度缝线内固定治疗髌骨横形骨折的疗效。. 2014 年 6 月–2016 年 6 月,采用高强度缝线内固定治疗 38 例髌骨横形骨折患者。男 24 例,女 14 例;年龄 26~64 岁,平均 45 岁。致伤原因:交通事故伤 6 例,摔伤 32 例。受伤至手术时间为 2~8 d,平均 5 d。术前疼痛视觉模拟评分(VAS)为(84.3±8.4)分,Lysholm 评分为(44.5±7.2)分,膝关节活动度为(62±12)°。. 术后患者切口均Ⅰ期愈合,无神经血管损伤、下肢深静脉血栓形成、局部异物刺激反应等并发症发生。术后 2 d X 线片检查示,髌骨骨折均达满意复位与稳定固定。患者术后均获随访,随访时间 12~18 个月,平均...
zh-cn
pair_29905047
To analyze the treatment of Gartland type Ⅱ and Ⅲ supracondylar fracture of the humerus in children. Between January 2015 and January 2017, 45 cases of Gartland type Ⅱ and Ⅲ supracondylar fracture of the humerus were treated. There were 28 boys and 17 girls with an age of 1-13 years (mean, 5.7 years). The causes of inj...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
总结儿童 Gartland Ⅱ、Ⅲ 型肱骨髁上骨折治疗经验。. 2015 年 1 月—2017 年 1 月收治 45 例肱骨髁上骨折患儿,其中男 28 例,女 17 例;年龄 1~13 岁,平均 5.7 岁。致伤原因:运动摔伤 43 例,高处坠落伤 2 例。骨折按 Gartland 分型,Ⅱ型 12 例,Ⅲ 型 33 例。受伤至手术时间 2~12 h,平均 4.6 h。先行闭合复位,其中 12 例 Gartland Ⅱ型闭合复位均获得成功;Gartland Ⅲ 型患儿中 20 例闭合复位成功,11 例复位失败者及 2 例合并桡神经损伤者改行前方横切口辅助复位。复位成功后行经皮交叉克氏针固定。. 手术时间 16~52 min,平均 3...
zh-cn
pair_29905048
To investigate pathogenesis, diagnosis, and treatment of crush syndrome of chest and arm. Between January 2010 and January 2015, 5 cases of crush syndrome of chest and arm caused by pressing oneself in a coma after CO poisoning or alcoholic intoxication were treated. There were 4 males and 1 female with an average age ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨上臂及胸壁挤压综合征的发病机制、诊断及治疗方法。. 2010 年 1 月—2015 年 1 月,收治 5 例由于 CO 中毒及饮酒昏迷后自身压迫导致的上臂及胸壁挤压综合征患者。其中男 4 例,女 1 例;年龄 28~46 岁,平均 36.7 岁。左上臂及左胸壁 2 例,右上臂及右胸壁 3 例。受压时间 4~12 h,平均 7 h。 5 例入院后急诊给予筋膜切开减压术联合封闭式负压引流,术后转入 ICU 给予连续性肾替代治疗(continuous renal replacement therapy,CRRT),待患者病情稳定后,肢体创面行游离植皮修复。. 患者住院时间 26~48 d,平均 33 d。1 例植皮术后皮片部分坏死,经...
zh-cn
pair_29905049
To explore the clinical application of combined transverse upper gracilis flap and adductor magnus perforator flap in breast reconstruction of breast cancer patients after mastectomy. Between August 2016 and February 2017, the combined transverse upper gracilis flap and adductor magnus perforator flap was used in 12 ca...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨股薄肌皮瓣联合大收肌穿支皮瓣在乳腺癌术后乳房重建中的应用及疗效。. 2016 年 8 月—2017 年 2 月,应用股薄肌皮瓣联合大收肌穿支皮瓣对 12 例乳腺癌患者行乳房重建。患者均为女性;年龄 32~59 岁,平均 41.5 岁。左侧 7 例,右侧 5 例。一期乳房重建 8 例,病理诊断为浸润性导管癌 4 例、浸润性小叶癌 4 例;病程 2~9 个月,平均 4.5 个月。二期乳房重建 4 例,乳腺癌改良根治术至该次手术时间为 12~70 个月,平均 37.4 个月。术中切取股薄肌皮瓣联合大收肌穿支皮瓣长 20~28 cm、宽 5.5~7.5 cm、厚 2.5~4.5 cm;股薄肌皮瓣血管蒂长度为 6.5~9.2 cm、大收肌...
zh-cn
pair_29905050
To investigate the effectiveness of levator muscle resection combined with Mustarde's double Z-plasty to correct blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). Between March 2015 and June 2017, one-stage operation of levator muscle resection combined with Mustarde's double Z-plasty were performed on 26 ch...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨提上睑肌缩短术联合 Mustarde 双 Z 形切除术矫正儿童小睑裂综合征(blepharophimosis-ptosis-epicanthus inversus syndrome,BPES)的疗效。. 2015 年 3 月—2017 年 6 月,采用提上睑肌缩短术联合 Mustarde 双 Z 形切除术一期矫正 26 例儿童双眼 BPES。其中,男 16 例,女 10 例;年龄 4~14 岁,平均 7 岁。均有典型的小睑裂四联征。7 例伴有鼻梁低平,20 例伴有弱视和斜视。睑裂长度(19.5±4.5)mm,睑裂宽度(2.5±1.6)mm,内眦间距(42.1±6.5)mm,提上睑肌肌力(5.5±1.3)mm。. 术后切口均Ⅰ期愈...
zh-cn
pair_29905051
To evaluate the effectiveness of a new type of sutured titanium wire combined with titanium nail internal fixation in correction of serious old medial canthus deformity. Between March 2012 and June 2015, 18 patients with unilateral serious old medial canthus deformity were treated. There were 14 males and 4 females. Th...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨新型缝合钛丝联合钛钉内固定矫正严重陈旧性内眦畸形的疗效。. 2012 年 3 月—2015 年 6 月,收治 18 例单侧严重陈旧性内眦畸形患者。男 14 例,女 4 例;年龄 23~62 岁,平均 42 岁。病因:交通事故伤 10 例,拳击伤 4 例,锐器划伤 3 例,动物咬伤 1 例。伤后患者均于外院采用缝线或钢丝内固定行内眦畸形矫正术但复发。该次手术与首次手术间隔 6 个月~2 年,平均 16 个月。术中采用鼻根部或内眦部皮肤瘢痕切口入路,充分松解内眦韧带与邻近组织瘢痕粘连,将新型缝合钛丝尾钩端固定于内眦韧带残端处,缝针端穿过陈旧瘢痕组织后缠绕固定于泪前嵴骨壁处钛钉,通过调节钛丝松紧确定内眦角的位置及形态。. 18 例患者...
zh-cn
pair_29905052
To evaluate the biomechanical effect of a nickel-titanium (Ni-Ti) three-dimensional memory alloy mesh in treating a canine tibial plateau collapse fracture model and to lay a foundation for further experiments <i>in vivo</i>. Sixteen tibial plateau specimens of 8 adult Beagle dogs were harvested. Twelve specimens were ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
通过将镍钛三维记忆合金网用于体外犬胫骨平台塌陷骨折模型并行生物力学试验,评价其生物学效能,为进一步动物体内实验奠定基础。. 取 8 只成年比格犬共 16 个胫骨平台标本,其中 12 个标本制备胫骨平台塌陷骨折(Schatzker Ⅲ型)模型后随机分为 A、B、C 组,每组 4 个;剩余 4 个正常胫骨平台标本作为空白对照组(D 组)。A、B 组分别于骨缺损处植入镍钛三维记忆合金网复合自体骨和自体骨,外侧钢板螺钉固定;C 组骨缺损处不植骨,外侧直接行钢板螺钉固定。使用 INSTRON-8874 生物力学测试系统由股骨髁上方垂直向下连续加载递增负荷(0~1 700 N),记录最大失效载荷,根据载荷-位移曲线计算刚度。. A、B、C、D ...
zh-cn
pair_29905053
To investigate the effect of human adipose-derived stem cells (hADSCs) on pressure ulcers in mouse. The subcutaneous adipose tissue from voluntary donation was harvested. Then the hADSCs were isolated and cultured by mechanical isolation combined with typeⅠcollagenase digestion. The 3rd generation cells were identified...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨人脂肪来源干细胞(human adipose-derived stem cells,hADSCs)对小鼠压疮创面愈合的影响。. 取自愿捐赠的人脂肪组织,采用机械分离联合胶原酶消化法获取 hADSCs 并传代。取第 3 代细胞行成骨、成脂、成软骨分化以及流式细胞仪鉴定。取健康自愿者捐赠的外周血,采用离心法制备富血小板血浆(platelet rich plasma,PRP),并行血小板计数。取 45 只 C57BL/6 小鼠采用磁铁夹压法于背部制备压疮模型,随机分为 3 组( <i>n</i>=15);hADSCs 组、PRP 组及对照组创面分别注射 100 μL 经携带绿色荧光蛋白(green fluorescent protei...
zh-cn
pair_29905054
To investigate the early effects of acellular xenogeneic nerve combined with adipose-derived stem cells (ADSCs) and platelet rich plasma (PRP) in repairing facial nerve injury in rabbits. The bilateral sciatic nerves of 15 3-month-old male Sprague-Dawley rats were harvested and decellularized as xenografts. The allogen...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨复合脂肪来源干细胞(adipose-derived stem cells,ADSCs)的脱细胞异种神经联合富血小板血浆(platelet rich plasma,PRP)修复兔面神经损伤的早期效果。. 取 15 只 3 月龄雌性 SD 大鼠双侧坐骨神经进行脱细胞处理,作为异种神经移植体。取成年新西兰大耳白兔颈背部脂肪垫,采用Ⅰ型胶原酶单独消化法分离培养 ADSCs;兔耳静脉采血后经两步离心法提取 PRP;观察不同体积分数 PRP 对 ADSCs 增殖的影响,以及诱导其为类雪旺细胞可行性。取第 3 代 ADSCs,CM-Dil 活细胞染色剂标记后,荧光显微镜观察细胞标记及传代后荧光衰减情况。另取 32 只新西兰大耳白兔建立左侧面神...
zh-cn
pair_29905055
To investigate the possibility and effect of chitosan porous scaffolds combined with bone marrow mesenchymal stem cells (BMSCs) in repair of neurological deficit after traumatic brain injury (TBI) in rats. BMSCs were isolated, cultured, and passaged by the method of bone marrow adherent culture. The 3rd generation BMSC...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
探讨壳聚糖多孔支架复合 BMSCs 移植修复大鼠创伤性脑损伤(traumatic brain injury,TBI)的可行性。. 取成年 SD 大鼠胫骨及股骨骨髓,采用全骨髓贴壁培养法分离培养 BMSCs,并传代。取第 3 代细胞行表面抗原 CD29、CD45 鉴定及 BrdU 标记。采用冷冻干燥法制备壳聚糖多孔支架,并与 BrdU 标记的第 3 代 BMSCs 进行体外共培养;扫描电镜观察细胞黏附情况,MTT 法检测支架内细胞生长情况。取 50 只成年 SD 大鼠,随机分为 A、B、C、D、E 组( <i>n</i>=10)。A~D 组大鼠采用 Feeney 自由落体打击致伤原理制备 TBI 模型,造模后 72 h 分别移植 BM...
zh-cn
pair_29905056
To review the basical research progress of porous tantalum in bone tissue engineering. The related basical research in fabrication, cytobiology, and surface modification of porous tantalum was reviewed and analyzed. The outstanding physiochemical properties of porous tantalum granted its excellent performance in biocom...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
对多孔钽在骨组织工程中的研究进展作一综述。. 查阅近年多孔钽在制备、细胞生物学、表面修饰等领域的基础研究文献,并总结分析。. 多孔钽自身特有的理化性质赋予其良好的组织相容性、骨整合能力,并可诱导软骨、肌腱修复再生。目前因多孔钽制备条件苛刻、成本较高等因素,限制了其临床广泛应用;新的制备方法及表面修饰技术的发展,为拓展多孔钽的应用范围,优化其骨组织修复再生能力提供了新的路径。. 多孔钽在修复骨缺损方面具有独特优势,但仍需在材料制备及表面修饰方面有进一步突破。.
zh-cn
pair_29905057
To summarize the research progress of rehabilitation after autologous chondrocyte implantation (ACI). The literature related to basic science and clinical practice about rehabilitation after ACI in recent years was searched, selected, and analyzed. Based on the included literature, the progress of the graft maturation ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
总结膝关节自体软骨细胞移植术(autologous chondrocyte implantation,ACI)术后康复的研究进展。. 查阅近年来国内外 ACI 术后康复相关的基础及临床研究,并进行总结分析。. 研究表明,ACI 术后移植物成熟分为 4 个阶段:增生期(术后 0~6 周)、过渡期(术后 6~12 周)、重塑期(术后 12~26 周)、成熟期(术后 26 周~2 年)。为了避免早期移植物损伤,适当刺激移植物和骨骼的整合过程,更快恢复关节功能,临床需针对术后不同阶段移植物的生物力学特性设计康复锻炼方案,主要体现在术后负重、运动范围、康复训练方式的过渡和调整。. 膝关节 ACI 术后应科学地逐步增加负重和运动范围,在不同阶段...
zh-cn
pair_29905059
To summarize the current progress of laser-assisted cartilage reshaping (LACR) for prominent ear. The domestic and abroad article concerning the LACR in treatment of prominent ear was reviewed and analyzed. As a new technique, there were three types of LACR therapies that been used for prominent ear. LACR with the 1 06...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
总结激光辅助软骨重塑形技术(laser-assisted cartilage reshaping,LACR)在临床矫正招风耳中的应用进展。. 查阅近年国内外有关 LACR 矫正招风耳的相关文献,并进行总结分析。. 作为一项临床新技术,目前 LACR 矫正招风耳方法主要有 3 种,其中 1 064 nm Nd/YAG 激光穿透性高,但组织损伤大,疼痛明显;1 540 nm Er/Glass 激光被耳廓软骨吸收率较高,对周围组织损伤小,不会造成明显疼痛;CO <sub>2</sub> 激光联合外科手术矫正招风耳,疗效确切,复发率低,但过程繁琐。术后坚持佩戴耳模是获得满意疗效的关键。此外,LACR 矫正招风耳也存在皮炎、皮肤灼伤、穿孔、感...
zh-cn
pair_29909692
The objective of this study is to investigate the association between oxytocin (OT) levels and repeated implantation failure (RIF) during in vitro fertilization-embryo transfer (IVF-ET) cycles. Blood samples were collected from 108 women undergoing IVF-ET treatment at the following time points: gonadotrophin (Gn) admin...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
摘要 目的:本研究的目的是评估IVF-ET周期中反复种植失败(RIF)和缩宫素(OT)水平之间的关系。 方法:收集了108名IVF-ET 患者四个时间点的血样:启动日 (Gn Day 0), 扳机日 (hCG Day 0), 胚胎移植日 (ET Day 0), 和胚胎移植后5天。测量三组的血清缩宫素和类固醇并比较: A组包括38名有RIF病史的女性, B组包括41名初次种植新鲜胚胎并怀孕的女性, C组包括29名初次种植新鲜胚胎但未怀孕的女性。 结果:三组不同时间点的OT水平无统计学差异。扳机日、胚胎移植日、移植后5天的OT值明显高于启动日, 而且与移植日的雌二醇水平有相关性。 结论:RIF患者在IVF-ET周期中OT水平没有明显升高...
zh-cn
pair_24415685
From October 2010 to October 2012 (total 126 days), we used the line transect method combined with interviews applied during seven individual surveys to explore the bird resources of Qomolangma National Nature Reserve (QNNR). Based on the historical records and the present results, a total of 390 bird species belonging...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
珠穆朗玛峰国家级自然保护区拥有世界第一峰珠穆朗玛峰,地跨古北界和东洋界。但一直以来由于缺乏详细调查而未能掌握其区系特点,影响了对珠峰生物资源的深入认识。2010年10月―2012年10月(126 d),采用样线法在保护区全境范围内对鸟类进行了7次系统实地调查,将原有记录从227种增加至390种。区系组成中,东洋界物种数多于古北界,分别为172和113种。南北坡区系差异明显,北坡以古北种为多,共55种,占北坡物种数的71.4%;南坡以东洋种为多,共168种,占南坡物种数的56.8%。在南坡,随海拔的升高,东洋种不断减少,而古北种先增加,在4 000 m后开始减少;两者在海拔3 100~4 000 m时数量相当。据此认为珠峰地区东洋界和...
zh-cn
pair_24415688
Animal coloration has many adaptive functions and plays an important role in signal communication both among intra- and interspecies. For example, it has been widely used in mate choice, intrasexual competition, and as aposematic or cryptic coloration in predator avoidance. Many colors and pigments also function in mic...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
体色是动物进行种内和种间信息交流的重要性状特征。与人类的三基色视觉系统不同,许多动物都具有四面体颜色系统,包括人眼无法探测的紫外光区域。动物体色是动物生态学中的一项重要研究内容,以人类主观角度对动物体色进行描述和分类,可能会导致研究结果的偏差,甚至得出错误结论。该文以赤红山椒鸟(<i>Pericrocotus flammeus</i>)为实例,通过分段光谱分析,对动物体色的色调、色度、亮度以及各波段的亮度进行量化;通过构建先进的动物视觉模型以考虑环境光线的影响和动物视网膜对不同波段光线的敏感度和捕获能力,同时将颜色斑块直观投射在四面体颜色空间和罗宾逊投影中,以量化颜色跨度和空间容量等参数,真正实现从动物的视觉角度分析动物体色。
zh-cn
pair_24415689
Periods of restricted food intake that lead to lower body weight are often followed by rapid regaining of the lost weight after ad libitum refeeding, an event generally known as the 'compensatory growth'. To explore the physiological mechanisms underlying 'compensatory growth', we evaluated a series of energetic parame...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
为阐明限食和重喂食(SFR-Re)诱导的体重“补偿性增长”生理机制,该文测定了SFR-Re驯化的KM小鼠能量摄入与支出、身体成分以及血清瘦素水平。结果显示,随机限食使体重显著降低,重喂食后体重增加至对照组水平。驯化结束后,SFR-Re驯化小鼠基础代谢率增加,产热降低,褐色脂肪组织(BAT)细胞色素c氧化酶(COX)活性和解偶联蛋白1(UCP1)水平显著降低,摄入能、消化率和脂肪重量均显著高于自由取食的对照组小鼠,但血清瘦素水平组间差异不显著。即在食物资源丰富的条件下,经历食物短缺的动物将增加能量摄入和消化吸收效率以及脂肪组织能量贮存,从而导致体重的“补偿性增长”,同时,血清瘦素可能在该过程中发挥重要作用。
zh-cn
pair_24415691
In this study, one-trial step-through task was applied to reveal the effect of prefrontal infralimbic cortex GABAA receptor agitating on passive avoidance memory consolidation in rats. Immediately after training (with shock), GABAA receptor agonist, muscimol (0.5 μg/0.25 μL) or saline (0.25 μL) was infused into the tes...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
该研究采用一次性步入法测试大鼠被动回避行为,以局部EEG功率变化作为蝇蕈醇失活前额叶下边缘区的效果指标,观察训练期和24 h后重测试时大鼠进入暗箱的潜伏期,旨在探讨激活前额叶下边缘区GABA<sub>A</sub>受体,可逆性失活该区神经元对大鼠被动回避记忆巩固过程的影响。结果发现,蝇蕈醇可显著降低大鼠前额叶下边缘区EEG总功率,但其被动回避作业重测试潜伏期与对照组无明显差异;即大鼠前额叶下边缘区GABA<sub>A</sub>受体被激活,导致该区神经兴奋性可逆性降低,但不影响被动回避记忆的巩固过程。
zh-cn
pair_24415693
Surveys about the breeding bird guild structure in karst forest of Nonggang Nature Reserve, Guangxi Zhuang Autonomous Region, were conducted successively in May-July 2010, 2011 and 2012. The feeding modes, foraging strata and foraging heights of 44 breeding bird species were analyzed by clustering and principal compone...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
于2010、2011和2012年5—7月在广西弄岗国家级自然保护区对喀斯特森林繁殖鸟类群落的集团结构进行了研究。对44种繁殖鸟类的取食方式、取食基层和取食高度进行聚类分析和主成分分析。其结果如下:(1)鸟类群落可分为6个取食集团,分别为地面取食集团、下层取食集团、上层取食集团、多层取食集团、树干取食集团和空中出击集团;(2)与其他森林类型的鸟类群落集团结构相比,喀斯特季节性雨林的鸟类群落以中、下层取食鸟类为主,多层取食集团次之。其原因可能是:弄岗喀斯特森林植被结构和鸟类食性特点形成了中下层取食的鸟类种数占优势的现象;鸟类以扩展各自生态位宽度方式来缓解竞争压力,从而形成了多层取食集团这一特点。
zh-cn
pair_24415694
The recently popularized non-denaturing fluorescence in situ hybridization (ND-FISH) is a new technique that is both quick and efficient, in part because denaturing of both of the probes and the chromosomes is unnecessary. Synthetic simple sequence repeats (SSRs) labeled with fluorescein are used as probes to detect SS...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
非变性荧光原位杂交(ND-FISH)是近年来兴起的一种技术,一般使用带有荧光标记的简单序列重复(SSRs)作为探针,杂交中不需要进行探针和染色体的变性使得检测简单快捷。SSRs探针可检测出染色体上SSR富集的区域,可以帮助辨识染色体,SSRs分布的多态性还可以为遗传多态性的研究提供信息。(1)该研究首次将ND-FISH运用于两栖动物中,得到了5个可运用于多态性研究的标记。(2)研究发现,有别于其他类群,当ND-FISH应用于两栖动物时,染色体标本必须进行变性。(3)该研究还对双色荧光原位杂交流程进行了较大的改进,在一个杂交体系中同时使用直接和间接标记探针,通过一次实验获得双色信号,从而使步骤简化。
zh-cn
pair_24415696
During April, July to August and November of 2012,three surveys were conducted to estimate the early-stage fish resources in the area of Liyuan power station on Jinshajiang River of Yunnan Province. During the survey conducted at the crossing of Daju Town, Yulong County, Yunnan Province, from July to August, 2012, two ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
该研究分别于2012年4月、7—8月及11月针对云南省金沙江梨园电站影响区域的鱼类早期资源进行了3次监测。并于2012年7—8月对云南省玉龙县大具乡大具渡口金沙江的监测中,发现中华金沙鳅(<i>Jinshaia sinensis</i>)卵汛两次,分别为8月1日8:00—4日10:00和8月9日23:00—13日6:00。结果发现,中华金沙鳅鱼卵卵径3.37~4.41 mm,平均3.89 mm,自然受精率为91.5%,模拟培养出膜率为97.1%,畸形率为2.2%;产卵场共3处,分别位于云南省玉龙县龙蟠镇、黎明乡和巨甸镇;三处产卵场两次产卵共计~1.49×10<sup>7</sup> ind.。此次产卵场的发现是对以往中华金沙鳅生物学...
zh-cn
pair_24415697
Ottelia acuminata was a dominant macrophyte in Dianchi Lake prior up through the 1970s, when it was thought to have gone extinct in 1976. Various theories have been proposed as to its extinction, with a particular focus on pollution-driven factors. By comparing the historical records on pollution and fish yields of Dia...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
1976年,曾经繁盛在滇池的海菜花群落消亡并引起了广泛讨论。该文通过对相关文献的整理和分析,重建了1950—2000年滇池水环境、水生植物与鱼产量变化趋势图,发现滇池外海海菜花消失的时间早于污染爆发,而与滇池鱼产量增加的时间基本一致,并由此提出:滇池外海海菜花群落消失主要归因于20世纪60年代草鱼的过量放养,而围湖造田和后期污染则使海菜花种群难以恢复。
zh-cn
pair_24415699
The prototype phylogenetic tree, i.e., evolutionary 'tree' or 'tree of life', was first conceived by Charles Darwin in his seminal book 'The Origin of Species', and its reconstructions have been approached by generations of biologists ever since. In this article, we briefly reviewed the major algorithms and software pa...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
系统发育树又称进化树、生命树等,在达尔文的“进化论”一书中首次出现,之后系统发育树的重构被广大生物学家所接受。该文阐述了构建系统发育树的基本流程,对目前用于构建系统发育树的四类算法(距离法、最大简约法、最大似然法和贝叶斯法)进行了详细地分析和比较,并介绍了一些常用系统发育树构建和分析软件(PHYLIP、MEGA、MrBayes)的特点。
zh-cn
pair_24415700
Social network analysis (SNA) is a framework used to study the structure of societies. As an umbrella term that encompasses various tools of graph theory and mathematical models to visualize networks, SNA allows researchers to detect and quantify patterns in social networks. Within SNA, individuals are not independent,...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
社会关系网络分析(social network analysis,SNA)是综合运用图论、数学模型,来研究个体与个体、个体与其所处社会网络、以及一个社会网络与另一社会网络之间关系的研究方法。SNA不仅仅是一套技术、而是一种关于关系网的方法论。该方法论认为每一个个体都不是独立的,而是通过信息、行为、空间分布、生态因素等连结共生。这让我们以全局视野理解一个动物群体,从两方关系、三方关系、个体与群体间关系、到动态网络模型等角度进行研究,为验证性行为与性选择理论、互惠与合作理论、信息流动与疾病传播理论、个体策略与种群选择理论、界定一个群、预测社会关系网络稳定性等行为生态学领域提供可靠的量化数据,极大地推动了行为生态学的发展。相对于国外的快速...
zh-cn
pair_24415702
Since water is a perfect medium for both bacteria and parasitic microbes, fish skin is constantly exposed to pathogen attacks. It is generally believed that skin mucus serves a mechanical as well as biochemical barrier. Lectins, an important part of the mucus, are carbohydrate-binding proteins that are neither antibodi...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
鱼类体表粘液是保护鱼体与水环境接触的一道物理和化学屏障,除包围入侵微生物外,还含有抗菌物质。其中,凝集素作为不同于免疫球蛋白且不具酶催化活性的糖蛋白,为体表粘液中所含有的重要免疫活性物质,在保护鱼体免遭外界环境中的病菌、寄生物和病毒侵袭中至关重要。该文以鱼类体表粘液凝集素为研究对象,结合国内、外研究成果,对其研究简史、分类、生物学性质和功能等进行阐述,为其今后的研究及应用提供参考。
zh-cn
pair_24415703
According to the extant records, there are a total of 165 species of fish along the middle and lower Langcangjiang River. However, in recent years, only 71 of these species have been be collected, indicating that fish resources of the middle and lower Langcangjiang River are declining, especially the medium-large and r...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
据记载,分布于澜沧江中下游的鱼类达165种,而近几年的调查结果显示,能采集到的仅71种,鱼类资源呈下降趋势。目前,澜沧江中下游的鱼类种类和数量减少(尤以大、中型及珍稀特有鱼类为甚),而外来种种类和数量增加。据此,该文提出了严防外来种逃逸、限制捕捞强度及开展增殖放流等建议。
zh-cn
pair_24415704
Chinese chiropterologists have made significant improvements into research on bat taxonomy and distribution. Overall, scholars recorded 6 new species of bats, alongside 11 species recorded species in the Chinese Mainland and 4 new bat species of Murina in Taiwan. Chinese chiropterologists intensively cooperated with th...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
21世纪以来,中国在蝙蝠区系分类、分布及生存现状的调查与研究方面突飞猛进,大陆学者已发表6个新种和11个中国新记录种,台湾学者也发表了4个管鼻蝠新种,区系面貌渐趋明晰;人才队伍逐渐壮大,国内与国际合作日益增多;研究内容与方法日趋深化和综合;物种保护意识明显增强;我国翼手目动物的研究呈现欣欣向荣的景象。然而总体上,中国目前的翼手目动物调查与研究还需进一步深入和精细化,一些隐蔽种仍有待揭示,今后在中国广大区域内特别是边境区域还很有可能发现新种或某些蝙蝠物种新的分布;已知的一些物种可能要进行新的分类修订和新的描述;需要绘制新的分布图和进行新的区划研究,还需尽快建立专门的翼手目物种信息网络交流平台,进一步加强国内外更广泛的学术交流与合作。中...
zh-cn
pair_24415705
As important traditional Chinese medicine materials, medicinal animals have been highly appreciated due to their strong bioactivities. Among these, medicinal insects have been thought to be significant, especially in preventing and treating modern diseases and tumors. Some of the most famous medicinal insects, such as ...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
动物药生物活性强、显效快,是中国医药学的重要组成部分,历来以“血肉有情”之品而备受重视。昆虫类中药药材在中国传统药物研究和利用中占有重要地位,特别是在治疗现代文明病和肿瘤方面具独特疗效。代表性昆虫类中药药材包括虻虫(牛虻)、斑蝥及美洲大蠊(<i>Periplaneta americana</i>)等,因具有显著抗血栓、治疗肿瘤等功效而得到长期应用。其药用功能和物质基础认知经历了从简单肤浅到深入清晰的过程,其利用也经历了由野外捕捉到人工规模化养殖、纯种品系培育,由简单、粗放加工全虫到精细利用单一成分、去害存益的历程。该文通过对牛虻的认识和利用变迁历程的初步梳理,揭示传统中药研究和应用与西药研发的相互影响,为中药现代化模式提供参考。
zh-cn
pair_24416661
Assess platelet rich plasma (PRP) injection for rotator cuff tendinopathy (RCT). Prospective open label study with 1-year follow-up. Participants recruited from an outpatient sports medicine clinic had clinically and magnetic resonance image (MRI)-demonstrated RCT refractory to physical therapy and corticosteroid injec...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目标:评估针对肩袖肌腱病的富 含血小板血浆 (PRP) 注射。设计:预期的开放标签研究,附 1 年跟进期。方法: 从运动医学门诊诊所招募 的参与者历经临床及磁共振成像 (MRI),证明物理治疗和糖皮质激 素注射治疗对RCT 呈现出难治性 他们接受了一次超声波 (US) 引导 的注射,对病变和周围肌腱进行 1% 利多卡因的 3.0 mL 注射和后 续 PRP 的 3.5 mL 注射。主要结 果:0–10 可视模拟量表(VAS;基 线、8、12 和 52 周)。次要结 果:评估肩袖强度和耐受力的肩 部功能测试(基线、 8 和 12 周)、MRI 严重度(1–5 分;(基 线、4 和 8 周)和患者满意度 (52 周)。结果:对 18 名...
zh-cn
pair_24416661
Assess platelet rich plasma (PRP) injection for rotator cuff tendinopathy (RCT). Prospective open label study with 1-year follow-up. Participants recruited from an outpatient sports medicine clinic had clinically and magnetic resonance image (MRI)-demonstrated RCT refractory to physical therapy and corticosteroid injec...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
Evaluar la inyección de plasma rico en plaquetas (PRP) para la tendinopatía del manguito de los rotadores. Estudio abierto prospectivo con I año de seguimiento. Métodos: Los pacientes captados de un consultorio ambulatorio de medicina deportiva presentaban pruebas clínicas y por resonancia magnética (RM) de tendinopatí...
es
pair_24416664
Healthcare in the United States is expensive and becoming more so every year. Policy and decision makers increasingly need information on costs, as well as effectiveness and safety, in order to formulate health-care strategies that are both clinically effective and financially responsible. Many people believe the benef...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
在美国进行医疗保健很昂贵,且年 年递增。政策和决策制定者越来越 需要获取关于费用,有效性和安全 性的信息,以制定临床有效且经济 的医疗保健政策。许多人相信补充和整合医学 (CIM) 的益处超过其成本。调查已显示美 国人口中有相当一部分使用 CIM 并直接为之付款。<sup>1</sup><sup>–</sup><sup>4</sup>最近的估算 显示美国 CIM 现款支付总额为 340 亿美元,占美国全部现款支付医疗 保健开支的 11%。<sup>1</sup>但是,如果要 在更宽泛的医疗保健策略中考虑 CIM,则必须确定其经济影响。理论上讲,CIM 似乎是有效控制成 本的良好候选,其甚至可节省成 本,因为其不用高科技,提供价廉 和...
zh-cn
pair_24416664
Healthcare in the United States is expensive and becoming more so every year. Policy and decision makers increasingly need information on costs, as well as effectiveness and safety, in order to formulate health-care strategies that are both clinically effective and financially responsible. Many people believe the benef...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La atención sanitaria en Estados Unidos es costosa y su coste aumenta cada año. Los encargados de la elaboración de las políticas y de la toma de decisiones necesitan cada vez más información sobre los costes, así como de la seguridad y eficacia, para formular estrategias de atención sanitaria que ofrezcan eficacia clí...
es
pair_24416663
Information about the safety of herbal medicine often comes from case reports published in the medical literature, thus necessitating good quality reporting of these adverse events. The purpose of this study was to perform a systematic review of the comprehensiveness of reporting of published case reports of adverse ev...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
目的:关于草药安全性的信息往 往来自医疗文献中发布的病例报 告,因而对这些不良事件进行高 质量的报告极为必要。本研究旨 在针对已发布的病例报告(对该 群体(儿童)使用草药相关的不 良事件的报告),就其全面性进 行系统性的审查。方法:包括对 7 个数据库进行电 子文献搜索和对从 2010 年以来检 索到的文章进行手动搜索。我们 纳入了已发布的病例报告和病例 系列,它们报告了与年龄不满 18 周岁的儿童接触草药制品有关的 不良事件。我们使用了描述性的 统计数据。根据国际流行病学会 “针对准备对外发布的不良事件 报告的提交指导方针”,我们向 每个病例报告制定并分配了指导 方针的遵从性得分 (0-17)。结果:96 篇独一无二的期刊论文 确...
zh-cn
pair_24416663
Information about the safety of herbal medicine often comes from case reports published in the medical literature, thus necessitating good quality reporting of these adverse events. The purpose of this study was to perform a systematic review of the comprehensiveness of reporting of published case reports of adverse ev...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La información sobre la seguridad de los productos fitoterapéuticos procede con frecuencia de informes de caso incluidos en publicaciones médicas, por lo que se necesita una notificación de buena calidad de estos acontecimientos adversos. El propósito de este estudio era realizar una revisión sistemática de la exhausti...
es
pair_24416665
The usefulness of clinical research depends on an assessment of causality. This assessment determines what constitutes clinical evidence. Case reports are an example of evidence that is frequently overlooked because it is believed they cannot address causal links between treatment and outcomes. This may be a mistake. C...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
此评估确定临床证据的构成。病 例报告是经常被忽视的证据,因 为人们相信这些报告无法解决治 疗与结果之间的因果链。这可能 是个错误。阐明因果关系及其评 估的主题对于研究人员和临床医 生将会大有裨益。临床研究的有 用性取决于对因果关系的评估。 此评估确定临床证据的构成。病 例报告是经常被忽视的证据,因 为人们相信这些报告无法解决治 疗与结果之间的因果链。这可能 是个错误。阐明因果关系及其评 估的主题对于研究人员和临床医 生将会大有裨益。本文概述了因果关系和因果关系 评估的整体系统。推荐的系统涉 及两个维度:横向和纵向;其中 每个维度都包含三种不同类型的 因果关系及因果关系评估的三种 对应类型。本系统中所包含的是 以日常生活和临床医学的例...
zh-cn
pair_24416665
The usefulness of clinical research depends on an assessment of causality. This assessment determines what constitutes clinical evidence. Case reports are an example of evidence that is frequently overlooked because it is believed they cannot address causal links between treatment and outcomes. This may be a mistake. C...
en
lexi-ml/wmt_22_dataset_en_zh-cn
train
text
La utilidad de la investigación clínica depende de una evaluación de la causalidad. Esta evaluación determina qué constituyen pruebas clínicas. Los informes de caso son un ejemplo de pruebas que suele pasarse por alto con frecuencia, ya que se cree que no pueden resolver las relaciones causales entre tratamiento y resu...
es