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pair_32009839 | A method is proposed that uses analysis of borehole stratigraphic logs for the characterization of shallow aquifers and for the assessment of areas suitable for manual drilling. The model is based on available borehole-log parameters: depth to hard rock, depth to water, thickness of laterite and hydraulic transmissivit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 提出了一种利用井孔地层测井资料分析浅层含水层的分析方法,并对适合人工钻孔的区域进行评估。该模型基于从可用井眼测井中提取的参数分析:浅层含水层深度与硬岩,水深,红土厚度和液压透过率。该模型适用于塞内加尔西北部的一个研究区域。钻孔日志的数据集已经使用研究期间开发的软件包(TANGAFRIC)进行处理。在指定描述岩性特征的标准类别的手动程序之后,下一步是使用文献中可用的参考值自动提取不同的结构参数和水力传导率的估计。通过与大直径井进行的一系列泵送试验的测量值进行比较,已经部分验证了从地层数据估算出的水力传导率值。结果表明,该方法能够利用该地区通用的信息,对浅层水文地质环境产生可靠的解释。该研究有助于改善条件适合手动钻孔的区域的识别。这是通... | zh-cn |
pair_32009839 | A method is proposed that uses analysis of borehole stratigraphic logs for the characterization of shallow aquifers and for the assessment of areas suitable for manual drilling. The model is based on available borehole-log parameters: depth to hard rock, depth to water, thickness of laterite and hydraulic transmissivit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Une méthode est. proposée utilisant l’analyse des logs stratigraphiques des forages pour la caractérisation des aquifères peu profonds et pour l’évaluation des zones favourable pour le forage manuel. Le modèle repose sur l’analyse des paramètres extraits des logs de forage disponibles: profondeur au socle, profondeur a... | fr |
pair_32009839 | A method is proposed that uses analysis of borehole stratigraphic logs for the characterization of shallow aquifers and for the assessment of areas suitable for manual drilling. The model is based on available borehole-log parameters: depth to hard rock, depth to water, thickness of laterite and hydraulic transmissivit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Um método é proposto usando análise estratigráfica de perfis de poços para a caracterização de aquíferos rasos e avaliação de áreas favoráveis para perfuração manual. O modelo é baseado na análise dos parâmetros extraídos de perfis de poços disponíveis: profundidade da rocha dura, profundidade da água, espessura da lat... | pt |
pair_32009839 | A method is proposed that uses analysis of borehole stratigraphic logs for the characterization of shallow aquifers and for the assessment of areas suitable for manual drilling. The model is based on available borehole-log parameters: depth to hard rock, depth to water, thickness of laterite and hydraulic transmissivit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Se propone un método que utiliza el análisis de registros estratigráficos de pozos para la caracterización de acuíferos poco profundos y para la evaluación de áreas aptas para la perforación manual. El modelo se basa en el análisis de parámetros extraídos de registros de pozos disponibles: profundidad de la roca dura, ... | es |
pair_32011012 | Chronic fatigue syndrome is an agnogenic disease worldwide. Nurses are at a high risk of chronic fatigue syndrome. However, no research has been done to examine the associations of workplace violence, organizational support, and occupational stress with chronic fatigue syndrome among Chinese nurses. This study aimed to... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 慢性疲劳综合征是一种病因不明的世界性疾病。护士患慢性疲劳综合征的风险很高。然而,目前尚无针对中国护士工作场所暴力、组织支持和职业压力与慢性疲劳综合征之间的关系的研究。本研究旨在探讨这些因素对该职业人群慢性疲劳综合征的影响。 设计: 横断面。所有参与者自愿完成问卷调查。 方法: 本研究于2017年12月至2018年1月在辽宁省进行。共向1,200 名护士发放自填问卷,包括付出收获不平衡、工作场所暴力量表、组织支持感问卷,以及年龄、性别、婚姻状况、教育程度、体育锻炼、职级、月收入、每周工作时间调查。共有1,080名(90%)参与者给出了完整答复。慢性疲劳综合征由医生根据疾病预防控制中心标准进行诊断。同时采用多变量逻辑回归对此类独... | zh-cn |
pair_32011772 | Small-scale fisheries are an important livelihood and primary protein source for coastal communities in many of the poorest regions in the world, yet many are overfished and thus require effective and scalable management solutions. Positive ecological and socioeconomic responses to management typically lag behind immed... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 小型渔业是世界上许多最贫困地区沿海社区的重要生计和主要蛋白质来源, 但许多地区存在着过度捕捞的现象, 因此需要制定有效且灵活的管理方案以应对这一问题。管理措施产生的积极的生态及社会经济响应通常滞后于渔民为渔业恢复需要减少捕捞压力而承担的直接成本。这些短期成本压力给干预措施的长期成功带来挑战。然而, 在生态和社会经济效益完全实现之前, 社会营销或有助于增进对管理效益的认知, 从而推动建立新的社会规范, 并最终实现长期可持续的行为改变。我们通过水下观测量化了水体生态条件, 并通过社区成员家庭调查量化了他们对管理支持和社会经济条件的看法, 从而评估了在巴西、印度尼西亚和菲律宾的 41 个地点实施的标准化小型渔业管理措施的影响。这些管理措施... | zh-cn |
pair_32011772 | Small-scale fisheries are an important livelihood and primary protein source for coastal communities in many of the poorest regions in the world, yet many are overfished and thus require effective and scalable management solutions. Positive ecological and socioeconomic responses to management typically lag behind immed... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Catalización del Manejo de Pesquerías Sustentables por medio de Intervenciones de Cambio de Comportamiento Resumen Las pesquerías a pequeña escala son un sustento importante y la principal fuente de proteína para las comunidades costeras en muchas de las regiones más pobres del mundo, sin embargo, muchas sufren de sobr... | es |
pair_32012257 | Impairments in family functioning are associated with more severe depressive and manic symptoms, earlier recurrences, and more suicidal behaviors in early-onset bipolar disorder. This study examined whether family-focused treatment for adolescents (FFT-A) with BD I or II disorder led to greater increases in family cohe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 家庭功能障碍与更严重的抑郁和躁狂症状, 较早的复发以及早期发作的躁郁症的更多自杀行为有关。本研究跟踪调查了患有BD I或II型疾病的青少年达两年时间, 比较两种治疗手段即家庭为中心的治疗(FFT-A)和较短时间的心理教育治疗(Enhanced Care; EC), 考察FFT-A是否能导致家庭凝聚力和适应性的更大程度的增加以及冲突的减少。参加者为144名青少年(平均年龄: 15.6±1.4岁), 在研究开始前三个月患有BD I或II级情绪障碍。青少年和父母被随机分配到FFT-A(21个疗程)或EC(3个疗程)。在整个为期2年的研究中, 患者均接受了基于指南的药物治疗。本文分析了两年时间里青少年和父母评估的家庭凝聚力, 适应性和冲突的... | zh-cn |
pair_32012257 | Impairments in family functioning are associated with more severe depressive and manic symptoms, earlier recurrences, and more suicidal behaviors in early-onset bipolar disorder. This study examined whether family-focused treatment for adolescents (FFT-A) with BD I or II disorder led to greater increases in family cohe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los problemas en el funcionamiento familiar están asociados con síntomas depresivos y maníacos más graves, recidivas en periodos más breves y más conductas suicidas en el trastorno bipolar de inicio precoz. Este estudio analizó si el “Tratamiento centrado en la familia para adolescentes” (Family-Focused Treatment for A... | es |
pair_32012334 | To determine what predicts health visitors' family-focused practice with mothers who have mental illness. To explore health visitors' experiences of family-focused practice and what factors, if any, enable and/or hinder it. A sequential mixed-methods design was employed. In Phase 1, a total of 230 health visitors, in f... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 确定哪些因素可预测健康访视人员针对患有精神疾病的母亲进行以家庭为中心的实践。探讨健康访视人员对以家庭为中心的实践的体验,以及哪些因素(如有)能够确保和/或阻碍以家庭为中心的实践。 设计: 采用序贯混合法设计。 方法: 在第一阶段,采用便利抽样法从英国五个健康和社会保健信托机构中共招募230名健康访视人员,并完成以家庭为中心的心理健康实践问卷。通过建立三个多元回归模型来检验工作量(模型一)、专业知识(模型二)以及健康访视人员的专业和个人经验(模型三)是否可预测其进行以家庭为中心的实践。在第二阶段,10名先前完成问卷调查的健康访视人员参加了半结构式访谈,描述他们以家庭为中心的实践的经验。这两个阶段的数据收集于2017年9月至20... | zh-cn |
pair_32015579 | Globally, countries have agreed to pursue the progressive realization of universal health coverage (UHC) and there is now a high level of political commitment to providing universal coverage of essential health services while ensuring that individuals are financially protected against high health spending. The aim of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在全球范围内,各国已同意逐步实现全民健康覆盖 (UHC),目前,各国在政治上高度致力于提供基本健康服务的全民覆盖范围,同时确保个人免受高额医疗支出的经济负担。本文旨在帮助政策制定者思考如何逐步实现全民健康覆盖 (UHC)。首先,讨论采用全球规范性支出目标来估算实现全民健康覆盖 (UHC) 所需的国家税收的困难。然后,对估算国家税收提出若干建议,这些建议不仅围绕全民健康覆盖 (UHC) 的成本问题,而且把重点放在推进全民健康覆盖 (UHC) 所需的国家医疗改革和政策选择上。特别是,建议将成本计算工作作为比较不同服务交付选择的工具,并建议对数据基础架构进行投资,以改进确定最佳政策所需的信息。这些建议旨在协助健康政策制定者以及正在制定逐步... | zh-cn |
pair_32015579 | Globally, countries have agreed to pursue the progressive realization of universal health coverage (UHC) and there is now a high level of political commitment to providing universal coverage of essential health services while ensuring that individuals are financially protected against high health spending. The aim of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | À l'échelle mondiale, les pays sont convenus de poursuivre la réalisation progressive de la couverture sanitaire universelle, et l'on observe désormais un fort niveau d'engagement politique en faveur de la couverture universelle des services de santé essentiels en veillant à ce que les individus soient financièrement à... | fr |
pair_32015579 | Globally, countries have agreed to pursue the progressive realization of universal health coverage (UHC) and there is now a high level of political commitment to providing universal coverage of essential health services while ensuring that individuals are financially protected against high health spending. The aim of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A nivel mundial, los países han acordado procurar la realización progresiva de la cobertura sanitaria universal (universal health coverage, UHC) y ahora existe un alto nivel de compromiso político para proporcionar una cobertura universal de los servicios sanitarios esenciales, al tiempo que se garantiza la protección ... | es |
pair_32015579 | Globally, countries have agreed to pursue the progressive realization of universal health coverage (UHC) and there is now a high level of political commitment to providing universal coverage of essential health services while ensuring that individuals are financially protected against high health spending. The aim of t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Страны мира пришли к соглашению о продолжении последовательной реализации программы всеобщего охвата услугами здравоохранения (ВОУЗ). В настоящее время обеспечение всеобщего охвата основными услугами здравоохранения с одновременным созданием финансовой защиты отдельных категорий лиц от высоких расходов на медицинское о... | ru |
pair_32015580 | Advancing the public health insurance system is one of the key strategies of the Senegalese government for achieving universal health coverage. In 2013, the government launched a universal health financial protection programme, <i>la Couverture Maladie Universelle</i>. One of the programme's aims was to establish a com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 推进公共医保体系是塞内加尔政府实现全民健康覆盖的关键战略之一。2013 年,政府发起了一项全民医疗财政保障计划,即 la Couverture Maladie Universelle。该计划其中的一个目标是为大部分 2013 年以前未投保的非正式部门人口建立一个以社区为基础的医保计划。该计划通过非营利性社区组织进行覆盖,截至 2016 年底,全国已建立 676 个组织。然而,这些组织现在正面临着诸如入学率低和福利方案不可大范围应用等难题。为了解决上述难题,改善社区医保计划的管理和运作,政府从 2018 年开始就计划并部分实施了两项重大改革。第一项改革包括一系列组织重组,加强风险分担。这些重组包括将风险分担和部分保险管理从个别组织转移... | zh-cn |
pair_32015580 | Advancing the public health insurance system is one of the key strategies of the Senegalese government for achieving universal health coverage. In 2013, the government launched a universal health financial protection programme, <i>la Couverture Maladie Universelle</i>. One of the programme's aims was to establish a com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Faire progresser le système public d'assurance maladie est l'une des principales stratégies du gouvernement sénégalais, qui ambitionne de rendre les soins de santé accessibles à tous. En 2013, le gouvernement a lancé un programme de protection financière global en la matière, la Couverture Maladie Universelle. L'un des... | fr |
pair_32015580 | Advancing the public health insurance system is one of the key strategies of the Senegalese government for achieving universal health coverage. In 2013, the government launched a universal health financial protection programme, <i>la Couverture Maladie Universelle</i>. One of the programme's aims was to establish a com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La promoción del sistema público de seguro médico es una de las estrategias clave del Gobierno senegalés para lograr la cobertura sanitaria universal. En 2013, el gobierno lanzó un programa de protección financiera universal de la salud, la Couverture Maladie Universelle. Uno de los objetivos del programa era establece... | es |
pair_32015580 | Advancing the public health insurance system is one of the key strategies of the Senegalese government for achieving universal health coverage. In 2013, the government launched a universal health financial protection programme, <i>la Couverture Maladie Universelle</i>. One of the programme's aims was to establish a com... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Развитие государственной системы медицинского страхования — одна из ключевых стратегий Правительства Сенегала для достижения всеобщего охвата услугами здравоохранения. В 2013 году правительство запустило универсальную программу финансовой защиты в сфере здравоохранения <i>la Couverture Maladie Universelle</i>. Одной из... | ru |
pair_32015581 | Optimizing the management of the health workforce is necessary for the progressive realization of universal health coverage. Here we discuss the six main action fields in health workforce management as identified by the Human Resources for Health Action Framework: leadership; finance; policy; education; partnership; an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 优化卫生人力管理是逐步实现全民健康覆盖的必然要求。这里我们讨论的是《卫生人力资源行动框架》中确定的卫生人力资源管理的六大行动领域:领导力;财政;政策;教育;伙伴关系;和人力资源管理系统。我们还确立并描述了发展卫生人力中有效做法的例子,强调政策制定者和规划者应注重思考问题时的广度。在这些行动领域取得成功是不可能分开进行的。相反,环环相扣、相互关联才能发挥出它们的价值,而这取决于有效管理卫生人力政策的强大能力。这种管理能力的最佳理解是由工具和因素组成的金字塔,它包括个人、组织、机构和卫生系统,每一级都取决于下一级的能力,并扶持上一级的行动。我们重点关注与卫生人力资源发展相关的组织或系统等级所涵盖的行动领域。我们认为,需要对政策和治理环境... | zh-cn |
pair_32015581 | Optimizing the management of the health workforce is necessary for the progressive realization of universal health coverage. Here we discuss the six main action fields in health workforce management as identified by the Human Resources for Health Action Framework: leadership; finance; policy; education; partnership; an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Il est nécessaire d'optimiser la gestion du personnel de santé pour parvenir progressivement à la couverture sanitaire universelle. Dans cet article, nous nous intéressons aux six grands domaines d'action en matière de gestion du personnel de santé qui sont définis dans le Cadre d'action concernant les ressources humai... | fr |
pair_32015581 | Optimizing the management of the health workforce is necessary for the progressive realization of universal health coverage. Here we discuss the six main action fields in health workforce management as identified by the Human Resources for Health Action Framework: leadership; finance; policy; education; partnership; an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La optimización de la gestión de la fuerza laboral sanitaria es necesaria para la realización progresiva de la cobertura sanitaria universal. La optimización de la gestión de la fuerza laboral sanitaria es necesaria para la realización progresiva de la cobertura sanitaria universal. En este documento se examinan los se... | es |
pair_32015581 | Optimizing the management of the health workforce is necessary for the progressive realization of universal health coverage. Here we discuss the six main action fields in health workforce management as identified by the Human Resources for Health Action Framework: leadership; finance; policy; education; partnership; an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Оптимизация управления кадровыми ресурсами в сфере здравоохранения необходима для последовательной реализации программы всеобщего охвата услугами здравоохранения. Авторы обсуждают шесть основных областей деятельности в сфере управления трудовыми ресурсами здравоохранения, которые определены в Рамочной программе действи... | ru |
pair_32015582 | Sustaining universal health coverage requires robust active public participation in policy formation and governance. Thailand's universal coverage scheme was implemented nationwide in 2002, allowing Thailand to achieve full population coverage through three public health insurance schemes and to demonstrate improved he... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 如需维持全民健康覆盖,就需要公众积极参与政策制定和治理。泰国计划于 2002 年在全国范围内实施全民健康覆盖,这将使得泰国通过三项公共健康保险计划实现全民覆盖,并有效改善公民健康状况。尽管自 1996 年以来,泰国在世界银行《全球治理指数》中的地位有所下降,但有关发言权和问责制的条款已纳入全民覆盖计划的立法和设计之中。我们探讨与公民权利和政府问责相关的法规是如何实施的。泰国宪法允许公民提交一项草案,其中关于发言权和问责制的条款已成功地纳入法规案文成为法律条文。该立法要求对受益人进行登记,开通一条 24/7 全天候服务的求助热线,每年举行公众听证会,并为经历过不良事件的患者提供无过错财政援助。相关执法机构需要有能力确保公民享有健康服务... | zh-cn |
pair_32015582 | Sustaining universal health coverage requires robust active public participation in policy formation and governance. Thailand's universal coverage scheme was implemented nationwide in 2002, allowing Thailand to achieve full population coverage through three public health insurance schemes and to demonstrate improved he... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Maintenir la couverture sanitaire universelle exige une forte participation publique à l'élaboration des politiques et à la gouvernance. En Thaïlande, le régime de couverture universelle a été mis en œuvre dans tout le pays en 2002, permettant de couvrir l'ensemble de la population grâce à trois régimes publics d'assur... | fr |
pair_32015582 | Sustaining universal health coverage requires robust active public participation in policy formation and governance. Thailand's universal coverage scheme was implemented nationwide in 2002, allowing Thailand to achieve full population coverage through three public health insurance schemes and to demonstrate improved he... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Para mantener la cobertura sanitaria universal se requiere una sólida participación activa del público en la formulación de políticas y la gobernanza. El plan de cobertura universal de Tailandia se implementó en todo el país en 2002, lo que permitió a Tailandia lograr una cobertura completa de la población a través de ... | es |
pair_32015582 | Sustaining universal health coverage requires robust active public participation in policy formation and governance. Thailand's universal coverage scheme was implemented nationwide in 2002, allowing Thailand to achieve full population coverage through three public health insurance schemes and to demonstrate improved he... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Поддержание всеобщего охвата услугами здравоохранения требует активного участия общественности в формировании политики и организации управления. Схема всеобщего охвата услугами здравоохранения Таиланда была внедрена на всей территории страны в 2002 году, что позволило Таиланду добиться полного охвата населения услугами... | ru |
pair_32015584 | Universal health coverage (UHC) means that all people can access health services of good quality without experiencing financial hardship. Three health financing functions - revenue raising, pooling of funds and purchasing health services - are vital for UHC. This article focuses on pooling: the accumulation and managem... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 全民健康覆盖 (UHC) 意味着所有人都可以享受优质医疗服务,同时不会遇到财务困难。三项医疗融资职能——提高收入、统筹资金和购买医疗服务——对于 UHC 至关重要。本文着重于统筹:积累和管理预付资金。统筹能够创造资源再分配的机会,有助于人人都能公平地享有所需的服务并且得到更大的财务保障。即使无法为 UHC 增加收入,依然会有保障。然而,在许多国家中,统筹安排非常分散,从而对再分配造成阻碍。本文的目的旨在简要概述统筹改革方案,以支持正在探索加强资金再分配方法的国家。我们概述四种类型的统筹改革并讨论其潜力以及在解决医疗融资分散问题时遇到的挑战:(i) 转为强制性或自主性全民覆盖;(ii) 合并不同的统筹方案以增加参保会员人数,同时提升参... | zh-cn |
pair_32015584 | Universal health coverage (UHC) means that all people can access health services of good quality without experiencing financial hardship. Three health financing functions - revenue raising, pooling of funds and purchasing health services - are vital for UHC. This article focuses on pooling: the accumulation and managem... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La couverture sanitaire universelle (CSU) consiste à ce que l'ensemble de la population ait accès à des services de santé de qualité sans encourir de difficultés financières. Pour cela, trois fonctions de financement de la santé sont essentielles: le recouvrement des recettes, la mise en commun des fonds et l'achat de ... | fr |
pair_32015584 | Universal health coverage (UHC) means that all people can access health services of good quality without experiencing financial hardship. Three health financing functions - revenue raising, pooling of funds and purchasing health services - are vital for UHC. This article focuses on pooling: the accumulation and managem... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La cobertura sanitaria universal (CSU) significa que todas las personas pueden acceder a servicios de salud de buena calidad sin experimentar dificultades financieras. Hay tres funciones de financiamiento de la salud que son fundamentales para la CSU: la recaudación de ingresos, la mancomunación de fondos y la compra d... | es |
pair_32015584 | Universal health coverage (UHC) means that all people can access health services of good quality without experiencing financial hardship. Three health financing functions - revenue raising, pooling of funds and purchasing health services - are vital for UHC. This article focuses on pooling: the accumulation and managem... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Всеобщий охват услугами здравоохранения (ВОУЗ) означает, что все люди могут получить доступ к качественным медицинским услугам, не испытывая финансовых трудностей. Три функции финансирования здравоохранения (сбор доходов, объединение средств и приобретение медицинских услуг) жизненно необходимы для достижения всеобщего... | ru |
pair_32015585 | The challenge of implementing contributory health insurance among populations in the informal sector was a barrier to achieving universal health coverage (UHC) in Thailand. UHC was a political manifesto of the 2001 election campaign. A contributory system was not a feasible option to honour the political commitment. Gi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 问题 如何在非正式部门人口中实施自缴型健康保险是泰国实现全民健康保险 (UHC) 的一大障碍。方法 实现全民健康保险 (UHC) 是 2001 年竞选活动的竞选宣言。自缴制度不是履行竞选宣言的可行方法。鉴于泰国的财政能力和所需有限的其他资源,泰国政府立法规定将普通税收作为全民健康计划的唯一资金来源。 当地状况2001 年以前,在 6350 万人口中,四大公共健康保险计划只覆盖了 70%(4450 万)的人口。卫生部收到预算,为低收入家庭提供医疗福利服务,并为非正式部门提供公费补贴的自愿保险。这些计划的供应方融资预算是根据历史数据编制的,而且这些数据不足以满足健康需求。财政部在预算分配决策中使用了它的自由裁量权。相关变化 税收成为为全... | zh-cn |
pair_32015585 | The challenge of implementing contributory health insurance among populations in the informal sector was a barrier to achieving universal health coverage (UHC) in Thailand. UHC was a political manifesto of the 2001 election campaign. A contributory system was not a feasible option to honour the political commitment. Gi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La difficulté de mettre en œuvre une assurance maladie contributive dans les populations du secteur informel faisait obstacle à la couverture sanitaire universelle (CSU) en Thaïlande. La CSU était au cœur de la campagne électorale de 2001. Pour respecter les engagements politiques, la mise en place d'un système contrib... | fr |
pair_32015585 | The challenge of implementing contributory health insurance among populations in the informal sector was a barrier to achieving universal health coverage (UHC) in Thailand. UHC was a political manifesto of the 2001 election campaign. A contributory system was not a feasible option to honour the political commitment. Gi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El reto de implementar un seguro de salud contributivo entre las poblaciones del sector informal era un obstáculo para lograr la cobertura sanitaria universal (universal health coverage, UHC) en Tailandia. La UHC fue un manifiesto político de la campaña electoral de 2001. Un sistema contributivo no era una opción viabl... | es |
pair_32015585 | The challenge of implementing contributory health insurance among populations in the informal sector was a barrier to achieving universal health coverage (UHC) in Thailand. UHC was a political manifesto of the 2001 election campaign. A contributory system was not a feasible option to honour the political commitment. Gi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Сложности внедрения основанной на взносах программы медицинского страхования среди групп населения в неформальном секторе препятствовали достижению всеобщего охвата услугами здравоохранения в Таиланде. Всеобщий охват услугами здравоохранения входил в политический манифест избирательной кампании 2001 года. Система взнос... | ru |
pair_32017183 | To assess the effectiveness of music therapy on the quality of life, anxiety, depression and pain of patients with cancer. Systematic review. Five electronic databases were searched in September 2018 for randomized controlled trials evaluating music therapy for patients with cancer. The quality of the studies was asses... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 评估音乐疗法对癌症患者生活质量、焦虑、抑郁情绪以及疼痛感受的效果。 设计: 系统评估。 数据来源: 2018年9月对五大电子数据库进行检索,以获取评价音乐疗法对癌症患者影响的随机对照试验。 评估方法: 采用Cochrane手册(5.1.0版)所推荐的偏倚风险评估工具对研究质量进行评估,同时使用Revman 5.3版软件进行荟萃分析。结果采用整体生活质量、焦虑、抑郁情绪和疼痛感受。 结果: 本研究共纳入19项试验,包括1,548 例患者的评价结果,其中对照组765例,实验组783例。与标准护理相比,音乐疗法能显著提高癌症患者的整体生活质量评分。此外,音乐疗法对降低焦虑、抑郁情绪和疼痛感受的评分也更为有效。 结论: 音乐疗法能提... | zh-cn |
pair_32017194 | The loss of forest is a leading cause of species extinction, and reforestation is 1 of 2 established interventions for reversing this loss. However, the role of reforestation for biodiversity conservation remains debated, and lacking is an assessment of the potential contribution that reforestation could make to biodiv... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 森林丧失是物种灭绝的主要原因, 而造林则是已确立的扭转森林丧失的两种干预措施之一。然而, 造林对生物多样性保护的作用仍存在争议, 目前尚缺乏造林对全球生物多样性保护潜在贡献的评估。我们考虑了社会经济和生态制约因素, 对 1550 个森林特有濒危物种的分布范围内可以造林的土地进行了空间重叠分析。据预测, 在至少 43% (约 3.69 亿公顷) 的可造林土地上实施造林, 将有助于受威胁脊椎动物的保护, 大约占受威胁脊椎动物分布总面积的15%。保护濒危脊椎动物的最大机会在热带地区, 特别是巴西和印度尼西亚。虽然再造林不能代替森林保护, 而且受威胁脊椎动物大部分栖息地仍是森林, 但我们的结果强调了认识到造林对生物多样性保护潜在重要贡献的全... | zh-cn |
pair_32017194 | The loss of forest is a leading cause of species extinction, and reforestation is 1 of 2 established interventions for reversing this loss. However, the role of reforestation for biodiversity conservation remains debated, and lacking is an assessment of the potential contribution that reforestation could make to biodiv... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Reforestación Mundial y Conservación de la Biodiversidad Resumen La pérdida de los bosques es una de las causas principales de la extinción de especies y la reforestación es una de las dos intervenciones establecidas para revertir esta pérdida. Sin embargo, el papel de la reforestación en la conservación de la biodiver... | es |
pair_32017199 | To explore Advanced Nurse Practitioners' (ANP) (Emergency) perceptions of their role, positionality and professional identity. Advanced nursing practice was formally established in the Republic of Ireland in 2001 with 336 ANPs currently registered, projection increasing to a critical mass of 750 by 2021. Advanced pract... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究高级执业护士(急诊部)对其角色、定位和职业认同的认知。 背景: 爱尔兰共和国于2001年正式发布高级护理实践,目前共注册了336名高级执业护士,预计到2021年人数将增加至750名。高级执业医师(急诊部)为一组计划外、未分化和未确诊的情况的特殊病人提供全面的急诊护理。 设计: 采用布迪厄的惯习、场域和资本概念为理论框架开展定性叙事研究。 方法: 通过10次深入访谈和专题分析来收集数据资料。 结果: 共出现了五大关键主题:参与者的职涯路径、个人和职业转变、角色维度和核心概念,以及在组织中的地位和自发职业认同。角色转换和惯习、场域、资本的变化揭示了护理角色具备独特性。尽可能缩短等待时间、及时的患者护理以及患者满意度为关键绩效... | zh-cn |
pair_32022301 | The Convention on Biological Diversity's (CBD) strategic plan will expire in 2020, but biodiversity loss is ongoing. Scientists call for more ambitious targets in the next agreement. The nature-needs-half movement, for example, has advocated conserving half of Earth to solve the biodiversity crisis, which has been tran... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 《生物多样性公约》的战略计划将于 2020 年到期, 但生物多样性丧失仍在继续。科学家们呼吁, 应在下一份协议中制定更宏伟的目标。例如, “自然需要一半” 运动主张保护半个地球以解决生物多样性危机, 这已经转化为保护每个生态区的 50%。本研究评估了《生物多样性公约》签署方之一的欧盟境内目前的生态区保护水平, 并探讨了将 Natura 2000 网络扩大到覆盖欧盟成员国保护区网络中 30% 或 50% 的生态区的可能性。根据最近的土地使用数据, 我们评估了各个生态区是否有足够的自然面积来实现如此之高的覆盖率目标。我们利用空间显式混合整数规划模型, 基于三种分别强调总保护成本、生态系统的生态代表性和成员国之间的责任均分的不同情景, 估... | zh-cn |
pair_32022301 | The Convention on Biological Diversity's (CBD) strategic plan will expire in 2020, but biodiversity loss is ongoing. Scientists call for more ambitious targets in the next agreement. The nature-needs-half movement, for example, has advocated conserving half of Earth to solve the biodiversity crisis, which has been tran... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Evaluación y Expansión de la Red de Áreas Protegidas de la Unión Europea hacia Objetivos Potenciales de Cobertura Post 2020 Resumen El plan estratégico del Convenio sobre la Diversidad Biológica (CBD) expirará en 2020, pero la pérdida de la biodiversidad continúa. Los científicos exigen objetivos más ambiciosos para el... | es |
pair_32022305 | The ongoing biodiversity crisis becomes evident in the widely observed decline in abundance and diversity of species, profound changes in community structure, and shifts in species' phenology. Insects are among the most affected groups, with documented decreases in abundance up to 76% in the last 25-30 years in some te... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 当前的生物多样性危机表现为物种数量和丰度的普遍下降、群落结构的明显变化和生物物候学的转变。昆虫是受影响最严重的群体之一; 记录表明, 过去25-30年间一些陆地生态系统昆虫丰度的下降高达 76% 。然而, 确定潜在的驱动因素仍阻碍重重, 因为大多数生态系统同时受到多种压力的影响, 且又常常缺少对环境变量的现场测量。本研究调查了德国最常见河流类型中的一条源头溪流, 它位于一个自然保护区内, 除气候变化外没有受到重大的人为影响。我们利用了目前水生昆虫最全面的长期定量数据集, 包括每周测量的昆虫物种丰度、每日水温和溪流流量, 以及42年来 (1969-2010年) 其它物理化学变量的观测数据。总体而言, 水温升高1.88°C , 流量就会... | zh-cn |
pair_32022305 | The ongoing biodiversity crisis becomes evident in the widely observed decline in abundance and diversity of species, profound changes in community structure, and shifts in species' phenology. Insects are among the most affected groups, with documented decreases in abundance up to 76% in the last 25-30 years in some te... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Cambios Complejos y No Lineales Causados por el Clima en Comunidades de Insectos de Agua Dulce durante 42 Años Resumen La continua crisis de la biodiversidad se vuelve evidente en la ampliamente documentada declinación en la abundancia y diversidad de especies, cambios profundos en la estructura de las comunidades y mo... | es |
pair_32023680 | The epidemic of the 2019 Novel Coronavirus (2019-nCoV) infection has presented as a grim and complex situation recently. More than 11,000 cases of 2019-nCoV infection has been confirmed in China until February 1<sup>st</sup> 2020, which are causing great impact to economy and society, and seriously interfering with ord... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目前2019新型冠状病毒(2019 Novel Coronavirus, 2019-nCoV)感染的疫情进入了一个严峻而复杂的局面。截止2020年2月1日,全国已有超过11000例新型冠状病毒感染确诊病例,给社会和经济带来极大影响,也严重影响着耳鼻咽喉头颈外科的日常医疗运行。本文针对耳鼻咽喉头颈外科的门诊及病房手术各个环节所需的医务防护措施进行讨论和建议,以期减少在2019-nCoV爆发和流行期耳鼻咽喉头颈外科医护人员的感染。. | zh-cn |
pair_32023681 | Since December 2019, China has been experiencing an outbreak of new infectious disease caused by 2019 novel coronavirus (2019-nCoV). The clinical features include fever, coughing, shortness of breath, and inflammatory pulmonary infiltration revealed by X ray. China rapidly identified 2019-nCoV-related pneumonia a statu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019年12月以来,我国陆续出现2019新型冠状病毒(2019-nCoV)感染引起的以肺部病变为主的新型传染病。临床特征是发热、干咳、气促及X线胸片炎症性改变等。我国已将2019-nCoV感染的肺炎定为法定传染病。为规范这一新发突发传染病的诊疗,特制订北京协和医院关于'2019-nCoV感染的肺炎'诊疗建议方案。. | zh-cn |
pair_32023682 | The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China's public health and clinical treatment. The virus belongs to the β genus Coronavirus in the family Corornaviridae, and is closely related to SARS-CoV and MERS-C... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019年岁末,在武汉暴发新型冠状病毒(2019-nCoV)引起的肺炎流行,给我国公共卫生和临床救治带来巨大挑战。2019-nCoV属于冠状病毒科β冠状病毒属,与严重急性呼吸综合征相关冠状病毒(SARS-CoV)和中东呼吸综合征相关冠状病毒(MERS-CoV)近缘,都会导致严重肺炎症状。该病毒经飞沫、接触等途径传播,潜伏期患者即具备传播性。目前数据表明:2019-nCoV比SARS-CoV毒力弱,但传播力强;造成其能够跨种传播的受体可能与SARS-CoV一致,都是血管紧张素转化酶Ⅱ(ACE2)。在此疾病暴发后,我国科技人员投入大量精力开展研究,快速开发出诊断试剂,初步确定了病原特性,并已筛选出可能抑制该病毒的临床药物,也正在加快研发... | zh-cn |
pair_32023684 | At the end of 2019, sporadic and clustered case with 'pneumonia of unknown origin' emerged in Wuhan, Hubei province. The causative pathogen was quickly confirmed as '2019-nCoV' . The epidemic soon spread throughout the country and became a pandemic in over a month. Government and medical institutions across the country... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019年末湖北武汉,首先发现以'不明原因发热伴肺炎'为主要症状的散发和聚集性病例,经确认是由2019-nCoV新型冠状病毒感染所致,疫情由早期确诊病例逐渐增加到近一月余全国各省份和其他国家出现蔓延态势。全国各医疗机构、各部门动员力量,采取多种措施,积极救治病人、扼制疫情进展。笔者用现有研究发现和资料,对此新型病毒的特点、对疾病的临床规律和诊疗重点、对确诊和疑似病例的临床科学管理以及对传染病防控的科学管理,进行了总结归纳并提出了思考。. | zh-cn |
pair_32023685 | The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV, which is genetically close to a bat-derived coronavirus. 2019-nCoV is categorized as beta genus coronavirus, same as the two other strains - severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle E... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019新型冠状病毒(2019-nCoV)是武汉不明原因肺炎的致病原。2019-nCoV在遗传学上与一种蝙蝠来源的新型冠状病毒比较接近,与SARS-CoV、MERS-CoV同为β属冠状病毒。目前临床上常用的抗病毒药物,包括神经氨酸酶抑制剂(奥司他韦、帕拉米韦、扎那米韦等)、更昔洛韦、阿昔洛韦、利巴韦林等药物对2019-nCoV均无效,不建议临床应用。目前研究证实可能有效的药物包括:瑞德西韦、洛匹那韦/利托那韦、洛匹那韦/利托那韦联合干扰素-β、恢复期血浆、单克隆抗体。但这些药物在2019-nCoV肺炎患者中的疗效和安全性有待进一步临床实验证实。. | zh-cn |
pair_32023687 | A recent epidemic of pneumonia cases in Wuhan China was caused by a novel coronavirus with strong infectivity, the 2019 novel coronavirus (2019-nCoV). The article provides the pulmonary rehabilitation (PR) methods in the principle of 4S (simple, safe, satisfy, save) for patients with pneumonia caused by the novel coron... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019新型冠状病毒(2019-nCoV)感染的肺炎具有高度传染性,本文结合4S(simple,safe,satisfy,save)呼吸康复内容和2019新型冠状病毒肺炎的诊治标准,对2019-nCoV所致的肺炎患者提供可行的呼吸康复指引。. | zh-cn |
pair_32023689 | The five-year overall survival rate with liver cancer currently ranks the second lowest among seventeen common malignant tumors in China. The occurrence and development of liver cancer is a process of progressive exacerbation. Nowadays, the clinical research is mainly aimed at the intermediate stage, that is, the explo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 当前肝癌的五年总生存率居我国十七种常见恶性肿瘤的倒数第二。肝癌的发生和发展是一个进行性加重的过程。目前的临床研究主要是针对中间阶段,即医院内阶段的诊疗原理及方法的探索。尤其是针对肝癌发生的癌前阶段和治疗后的康复阶段的研究现在还严重不足。提出阶梯式防治的策略旨在强调只有对肝癌患者进行全病程的防治研究,才有可能显著改善我国肝癌的总体疗效。. | zh-cn |
pair_32023690 | The concept of precancerous lesions was first proposed in 1948. With the progress of animal models, genetic analysis, clinical pathology, and imaging studies, precancerous lesions have received much attention, and the reversion of precancerous lesions has also attracted widespread concern. Precancerous lesions are not ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 癌前病变的概念最早于1948年被提出,随着动物模型、基因分析、临床病理学及影像学研究的发展,癌前病变备受重视,对癌前病变的逆转也被广为关注。癌前病变并不是癌,也不是癌的早期,它们与癌有质的区别;癌前病变仅是其中的小部分可能演变为癌症。重视癌前病变的诊治管理对防癌、治癌和维护人们身心健康有重要意义。. | zh-cn |
pair_32023691 | Hepatocarcinogenesis is a multi-step process in which detection of precancerous lesions and advanced hepatocellular carcinoma in its progressive stage is crucially important for predicting tumor behavior, estimating the extent of lesions, implementing the optimal treatment strategy, and improving the survival of patien... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝细胞癌(HCC)发生是一个多步骤过程,在其发展中检测出HCC癌前病变和进展期HCC,对预测肿瘤行为、判断病变程度、采用最佳治疗策略、改善患者生存至关重要。肝脏成像技术的快速进展和广泛应用,尤其是肝细胞特异性对比剂钆塞酸二钠MRI(Gd-EOB-DTPA MRI)可提供肝结节血管变化、肝细胞功能信息,能够精确区分肝硬化再生结节、低度异型增生结节、高度异型增生结节、早期HCC(early HCC)和HCC,从而进行恶性进展的风险度分层。现综述Gd-EOB-DTPA MRI在HCC早期诊断中的价值,分析HCC多步发展过程中的关键概念,以及癌前病变最终可能转化成典型HCC的影像学表现。. | zh-cn |
pair_32023692 | Hepatocellular carcinoma (HCC) currently holds the second position for cause of cancer-related deaths in China. Most of the pathogenic characteristics of HCC in China follow the tri-step model of hepatitis B-cirrhosis-liver cancer. The screening of precancerous lesions of stomach cancer, colorectal cancer and cervical ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝癌目前占我国癌症死因的第二位。我国肝癌的发病特点大多遵循乙型肝炎-肝硬化-肝癌的'三步曲'模式。癌前病变的筛查在胃癌、大肠癌和宫颈癌等恶性肿瘤的诊治中已取得了显著的成果。肝硬化状态下的不典型增生结节具有较强的恶变潜能,尤其是高级别不典型增生结节癌变率极高。基于国内外在这一领域的研究成果和专家临床经验,《肝细胞癌癌前病变的诊断和治疗多学科专家共识(2020版草案)》经多学科协作对肝脏高级别不典型增生结节作为肝癌的癌前病变,从概念、筛查、诊断、治疗和随访等各方面进行了归纳和界定,旨在提出和建立肝癌癌前病变的概念和诊疗原则,为降低我国肝癌的发病率和提高肝癌的总体治疗效果作出贡献。. | zh-cn |
pair_32023694 | Recently, the Society of Infectious Diseases of Chinese Medical Association and Chinese GRADE Center jointly released the '2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission' . We concerned several issues in the Guideline, including the improper citation o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 中华医学会感染病学分会和GRADE中国中心最近发布了《中国乙型肝炎病毒母婴传播防治指南(2019年版)》。该指南存在参考文献引用不当,对预防乙型肝炎病毒母婴传播的部分关键策略缺乏推荐意见,部分推荐意见证据不足或缺乏证据等问题。本着学术争鸣原则,现对该指南提出一些管见,愿与作者和读者商榷。. | zh-cn |
pair_32023707 | The early diagnosis and effective treatment of hepatocellular carcinoma (HCC) still remains a difficult problem that plagues the medical community. Exosomes are microvesicles with a diameter of 40~100 nm, and contains proteins, lipids and nucleic acids (mRNAs, lncRNAs, circRNAs, and microRNAs). They serve as an informa... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝细胞癌(HCC)早期诊断和有效治疗,仍然是困扰医学界的难题。外泌体是直径为40~100 nm的微小囊泡,内含蛋白质、脂质和核酸,作为信息物质交换的转运载体,在调控生物分子功能、维持细胞内环境中起重要作用。HCC外泌体功能包括胞间信息交换、新血管生成、癌细胞转移与多药耐药等,可介导微小RNA(miRNA)转化以调控肿瘤进展的微环境,进而影响癌细胞的病理生理学行为。外泌体源性miRNA可用于HCC监测或为早期诊断潜在特异标志物,且可作为HCC治疗靶目标,具有开发应用前景。现综述HCC外泌体源性miRNA研究的新进展。. | zh-cn |
pair_32023709 | Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells, and hence ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 细胞外囊泡是双层脂质膜小囊泡,可以由大多数类型的细胞释放,并在大多数体液中可检测到,细胞外囊泡可将其生物活性成分转移到受体细胞或激活靶细胞中的信号转导,发挥细胞间通讯的关键功能,从而参与多种疾病包括肝脏疾病的发生和发展。近年来非酒精性脂肪性肝病患病率上升,除有创的肝活组织检查外,目前还没有可靠的肝脏炎症诊断或纤维化分期方法,寻求相应的无创循环标志物的研究持续活跃,细胞外囊泡是其中较受关注者之一。为此综述了目前关于细胞外囊泡的物理特征、生物成分和分离方法的知识,并介绍了利用循环细胞来源囊泡作为非酒精性脂肪性肝病诊断新标志物的概念。. | zh-cn |
pair_32023711 | Phages can fight against sepsis through directly lysing the bacteria and influence the patients' self-response to the pathogens through the immunomodulation effects in a coordinated way. Under the situation of the rising antimicrobial resistance, phage has attracted wide attention of researchers at home and abroad. Alo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 噬菌体可以直接裂解细菌对抗脓毒症,同时还可以通过免疫调节效应影响患者自身对病原菌的反应,起到协同对抗感染的作用。在抗生素的耐药性逐渐升高的情况下,噬菌体受到了中外研究者的广泛关注。随着噬菌体研究的深入,以及相关临床试验的不断开展,我们相信将噬菌体应用于脓毒症的治疗指日可待。. | zh-cn |
pair_32023712 | Cold injury is very damaging. This article summarizes the mechanism, types, and rehabilitation of cold injury, focusing on the degree and clinical treatment of frostbite. Frostbite can mainly cause damage of microcirculation and capillary structure, while burn injury can mainly cause damage of cutaneous tissues. Based ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 冻伤是一种危害较大的损伤。为此本文总结冻伤的损伤机制、类型及康复,并介绍冻结伤分度与临床治疗。冻结伤主要造成微循环以及血管结构的破坏,而烧伤主要造成皮肤组织的损伤。冻结伤的治疗关键是适当的复温、微循环治疗,烧伤则以创面修复为主。目前冻结伤导致的截肢率仍然很高,其后遗症的康复治疗是现代医学面临的一大挑战,值得同仁们更多研究关注。. | zh-cn |
pair_32023721 | On 18th October 2018, a 49 years old man with right thigh proximal medial swelling and pain was received in the Department of Pathology, People's Hospital of Deyang of Sichuan Province. The patient had experienced amputation twice because of burn in right lower limb 46 years ago. Cicatricial squamous cell carcinoma met... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2018年10月18日四川省德阳市人民医院病理科接诊1例右大腿近端内侧肿胀疼痛的49岁男性患者。患者因46年前右下肢烧伤已行2次截肢术,在笔者科室行细针穿刺细胞学检查诊断为右大腿内侧瘢痕性鳞状细胞癌转移,患者于上一级医院行局部活检后伤口仍溃烂不愈,患者要求化学治疗,于行第1周期化学治疗后10 d死亡。该病例提示临床医师针对烧伤后瘢痕溃疡应及早进行病理学检查,避免延误治疗时机,导致癌变恶化及转移。. | zh-cn |
pair_32023722 | On October 23, 2017, a 52-year-old male patient with 3 recurrences of dermatofibrosarcoma protuberans in the left shoulder and chest was admitted to the Department of Burns and Plastic Surgery of Dali Bai Autonomous Prefecture People's Hospital. Dermatofibrosarcoma protuberans on the skin were completely resected, leav... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 大理白族自治州人民医院烧伤整形外科于2017年10月23日收治1例左肩胸部隆凸性皮肤纤维肉瘤3次复发的52岁男性患者。手术完全切除皮肤隆凸性纤维肉瘤,创面缺损10 cm×10 cm,预计用右股前外侧穿支分叶皮瓣游离移植修复创面,但切取皮瓣时见股前外侧穿支部分缺如,仅见1条细小穿支,并且分离困难,遂放弃。通过相同的切口向内侧寻找股前内侧穿支血管,见1条粗大穿支,由独立的源动脉供血,血管蒂长度、口径与受区血管匹配。利用该穿支切取10 cm×10 cm的股前内侧穿支皮瓣修复缺损,供瓣区直接缝合。术后9个月随访,皮瓣颜色、质地、厚薄好,两点辨别觉距离30 mm,右大腿供瓣区遗留线状瘢痕。. | zh-cn |
pair_32023723 | Fournier gangrene is a relatively rare clinical critical disease, and its clinical symptoms are not specific and easily unrecognized by some clinicians. It has the features of acute onset, quick development, severe illness, and often accompanied by infection shock which is seriously life-threatening. It is difficult in... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Fournier坏疽是临床上较罕见的急危重症,其症状不具特异性,极易误诊,又具有起病急、进展快、病情重、常伴随感染性休克而严重危及患者生命的特点。Fournier坏疽治疗难度大、医疗成本高,患者住院时间长,既增加了患者及家属的痛苦,也为患者、社会及医务工作者带来了沉重的经济和心理负担。笔者查阅国内外文献并结合临床经验,从Fournier坏疽的定义、流行病学、临床表现、诊断、治疗等方面进行总结,供广大临床工作者参考。. | zh-cn |
pair_32023724 | Children are a high-risk group of burn, and burn pain is a special type of pain. Because children of different ages have different cognitive ability and behavioral response to pain, thus it is particularly difficult to effectively evaluate the pain. It is very important for medical staff to understand the pain of child... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 小儿是发生烧伤的高危人群,烧伤疼痛是一种特殊类型的疼痛。由于不同年龄段的患儿对疼痛的认知能力及行为反应存在差异,故针对小儿进行有效疼痛评估尤为困难。了解患儿的疼痛,明确疼痛的不良反应,及时有效地评估及采取合适的疼痛干预措施对于医护人员至关重要。本文针对小儿烧伤疼痛的不同评估方法及非药物干预相关措施进行综述,以期为临床提供参考。. | zh-cn |
pair_32023764 | Immune checkpoint inhibitors have been approved for clinical application in China. However, the increased immune-related adverse event (irAE) needs more attention. This review summarized the incidence, characteristic clinical manifestation and treatment of irAEs associated with programmed cell death protein-1(PD-1) and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 免疫检查点抑制剂已在我国被批准进入临床应用,随之而来的免疫相关不良反应(irAE)需引起临床医师的关注。文章总结了针对抗程序性细胞死亡蛋白和程序性细胞死亡蛋白配体抗体引起的irAE发病率、特征性临床表现以及治疗方法,探讨了其可能的发病机理、不同类型恶性肿瘤发病率的差别、影响因素以及未来的研究方向,为临床肿瘤医师对肿瘤irAE的识别和监控加以指导。. | zh-cn |
pair_32023765 | The successful application of tyrosine kinase inhibitor (TKI) has kicked off the targeted therapy of epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) since the discovery of EGFR gene mutations. Patients harboring the two most classic representative mutations of EGFR gene including exon ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 自表皮生长因子受体(EGFR)基因突变被发现以来,酪氨酸激酶抑制剂(TKI)的应用拉开了EGFR阳性非小细胞肺癌精准靶向治疗的序幕。携带EGFR基因常见的两类经典代表性突变,即第19号外显子框内缺失突变和第21号外显子L858R点突变(约占所有EGFR突变的90%)的非小细胞肺癌患者,接受TKI靶向治疗的临床获益远远优于传统化疗。EGFR基因第20号外显子插入突变却与众不同,在剩余10% EGFR少见基因突变中为最常见的类型,且这类突变中的绝大多数对目前临床应用的第一、二、三代TKI原发耐药,临床预后差。目前,国际上亦缺乏针对此突变的深入研究和临床治疗指南。文章介绍了EGFR基因20号外显子插入突变型非小细胞肺癌的发病机制、氨基酸序... | zh-cn |
pair_32023774 | Gene mutations can impair the sensitivity of cancer cells to targeted drugs, and lead to individual differences of clinical therapeutic effects. Epidermal growth factor receptor (EGFR) mutation plays an important role in therapeutic decision-making. Furthermore, some co-existing gene mutations, such as TP53 mutation, c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 基因突变能够影响肺癌细胞对靶向药物的敏感性,导致个体化临床治疗效果出现差异。表皮生长因子受体(EGFR)的突变状态在内科药物治疗决策中具有重要意义。此外,其他并存的基因突变均可影响疾病的治疗效果和患者的远期临床预后。EGFR突变合并TP53突变是否可改变肺癌细胞对酪氨酸激酶抑制剂治疗的敏感性和对远期预后的影响一直受到人们的关注。目前在临床实践中,TP53的突变状态并不是临床治疗决策中的参考依据,因此需要进一步的证据阐明TP53(包括各亚型)突变状态对EGFR靶向治疗潜在获益的影响,以指导非小细胞肺癌的治疗。. | zh-cn |
pair_32025191 | The Indo-Gangetic aquifer is one of the world's most important transboundary water resources, and the most heavily exploited aquifer in the world. To better understand the aquifer system, typologies have been characterized for the aquifer, which integrate existing datasets across the Indo-Gangetic catchment basin at a ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 印度-恒河含水层是世界上最重要的跨界水资源之一,也是世界上开采量最大的含水层。为了更好地了解含水层系统,结合现有的印度-恒河流域盆地数据,第一次在跨界尺度上对含水层的类型进行了特征描述,提供了这个含水层系统供选择的概念模型。传统上,被认为并被绘制为可比较含水层特性的单一均质含水层及跨界尺度上地下水资源,类型学阐明了这个跨界尺度上含水层系统补给、透水率、储存量和地下水化学上的重要空间差别。这些变化显示与更新世和全新世冲积含水层、气候和最近灌溉实践沉积学上的大尺度变化是系统性的、也是一致的。展示了含水层的七个类型,每个类型都具有一套独特的地下水开发的挑战和机会以及针对抽水和气候变化的不同恢复力。七个类型为:(1)山前边缘;(2)印度河上... | zh-cn |
pair_32025191 | The Indo-Gangetic aquifer is one of the world's most important transboundary water resources, and the most heavily exploited aquifer in the world. To better understand the aquifer system, typologies have been characterized for the aquifer, which integrate existing datasets across the Indo-Gangetic catchment basin at a ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’aquifère de l’Indus et du Gange est une des ressources en eau transfrontalière la plus importante au monde et un des aquifères le plus exploité au monde. Pour mieux comprendre le système aquifère, des typologies ont été caractérisées pour cet aquifère ; elles intègrent pour la première fois un jeu de données disponib... | fr |
pair_32025191 | The Indo-Gangetic aquifer is one of the world's most important transboundary water resources, and the most heavily exploited aquifer in the world. To better understand the aquifer system, typologies have been characterized for the aquifer, which integrate existing datasets across the Indo-Gangetic catchment basin at a ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | O aquífero do Indo-Gangético é um dos recursos hídricos transfronteiriços mais importantes do mundo, e o mais explorado. Para melhor entender o sistema aquífero, tipologias foram caracterizadas para o aquífero, que integram pela primeira vez bancos de dados existentes sobre a bacia de abastecimento Indo-Gangética em um... | pt |
pair_32025191 | The Indo-Gangetic aquifer is one of the world's most important transboundary water resources, and the most heavily exploited aquifer in the world. To better understand the aquifer system, typologies have been characterized for the aquifer, which integrate existing datasets across the Indo-Gangetic catchment basin at a ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El acuífero Indo-Gangético es uno de los recursos hídricos transfronterizos más importantes y el acuífero más explotado del mundo. Para comprender mejor el sistema acuífero, por primera vez se han caracterizado tipologías para el acuífero, integrando los conjuntos de datos existentes a través de la cuenca hidrográfica ... | es |
pair_32026484 | To analyse the effect of mindfulness training on levels of burnout among nurses. Burnout syndrome is a common occupational hazard for nursing staff. Mindfulness training has been proposed as a valid intervention for burnout. Systematic review and meta-analysis. The CINAHL, LILACS, Medline, ProQuest, PsycINFO, Scielo an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 分析正念训练对护士职业倦怠程度的影响。 背景: 倦怠综合征对护理人员来说是一种常见的职业危害。而正念训练被认为是一种有效的职业倦怠干预措施。 设计: 系统评估与荟萃分析。 数据来源: 通过使用搜索方程‘Nurs*和倦怠与正念’在CINAHL、LILACS、Medline、ProQuest、Psychinfo、Scielo和Scopus数据库中进行检索(不限制文献出版年份)。 评估方法: 根据PRISMA指南选择论文进行分析。使用Review Manager 5.3软件进行荟萃分析。 结果: 共选取17篇文献,包括632名护士。结果显示,正念训练可降低职业倦怠程度,而情绪衰竭和人格解体得分较低,个人成就感得分较高。干预组和对照... | zh-cn |
pair_32026486 | To explore next of kin satisfaction with cancer care, map next of kin suggestions for involvement and combine this information to create a basis for improving quality and safety in hospitals. Convergent parallel mixed-methods design applying the 20-item FAMCARE Scale survey instrument for quantitative measurement of sa... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨直系亲属对癌症护理的满意度,绘制直系亲属参与建议图,并结合此类信息,为提高医院护理质量和安全性奠定基础。 设计: 采用集合并行混合法设计,使用20个条目FAMCARE量表对护理满意度进行定量测量,并采用开放式问题进行定性分析。 数据来源: 238名直系亲属(2016年11月至2017年11月)的回复。 方法: 探索性因素分析、回归分析与定性内容分析相结合。 结果: 两所医院在医疗方面的得分(中位数,四分位数范围:1.5,1.1-2.0)均高于直系亲属对信息和参与度的满意度得分(1.9,1.3-2.4),p< .001(威尔科克森符号秩检验)。在调整了人口统计学和临床变量的差异后,其中一家医院的FAMCARE总分高出13%... | zh-cn |
pair_32026506 | To examine the effects of a tailored telehealth educational intervention on medication adherence and disease activity in discharged patients with rheumatoid arthritis (RA). An un-blinded randomized controlled trial. A total of 92 eligible patients were recruited from January 2015-December 2015. Participants were random... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨针对性的远距照护教育干预对类风湿性关节炎(RA)出院患者用药依从性和疾病活动性的影响。 设计: 非盲随机对照试验。 方法: 自2015年1月至2015年12月期间共招募92名符合条件的患者。将参与者随机分为两组:干预组(N=46)和对照组(N=46)。干预组在为期12周的干预措施中通过电话共接受了4次照护教育。教育内容主要包括:受试者疾病知识指导;治疗目标;正确服药的重要性;副作用管理;记住服药。而对照组仅接受标准护理,包括出院指导。结果指标包括用药依从性和疾病活动性。 结果: 干预组在第12周和第24周的用药依从性明显高于对照组。两组在第12周和第24周的疾病活动性无显著差异。 结论: 通过电话进行的针对性的教育干预可... | zh-cn |
pair_32026509 | The purpose of this paper was to perform a bibliometric analysis of the production of qualitative research in scientific journals through aggregation by levels and to identify factors of diversity, such as types of designs, in qualitative research on the experience of having an intestinal stoma between 2002 and 2018. D... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 本文旨在通过分级汇总对科学期刊定性研究成果进行文献计量分析,从而确定2002年到2018年期间发表的有关肠造口术后患者的定性研究中设计类型等多样性因素。 设计: 描述性文献计量研究侧重于在微观、中观和宏观三个层面上对研究对象展开定性研究。 方法: 通过PubMed、CINAHL、Web of Knowledge、Scopus、SciELO、CUIDEN、Lilacs和谷歌学术搜索等数据库对2018年8月至11月间发表的文献数据进行检索。 结果: 护理是一大主要知识领域。巴西是主要来源国。最有成效的期刊为《创面、造口及自制护理杂志》。英语和葡萄牙语是科学交流的两大主要用语。作者人数通常在2到6人之间。作者还开展了描述性和现象学... | zh-cn |
pair_32027245 | To investigate the incidence, clinical features of U2AF1 gene mutation in patients with acute myeloid leukemia(AML) and its effect of prognosis. A total of 161 patients with AML were enrolled. The second-generation sequencing method was used to detect U2AF1 gene mutation, and the relationship between U2AF1 mutation and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 急性髓系白血病患者U2AF1基因突变的临床特征及预后分析. 探讨U2AF1基因突变在急性髓系白血病(AML)患者中的发生率、临床特点和其对预后的影响. 选取161例AML患者,应用二代测序方法检测U2AF1基因突变情况并分析其临床特征和治疗预后的关系. 161例AML患者中,U2AF1基因突变率为3.73%。U2AF1基因突变组外周血白细胞数和血小板数较野生型组低。U2AF1基因突变组完全缓解率为66.67%,野生型组为55.48%,两者无统计学差异(P=0.70)。U2AF1基因野生型组和突变组的中位无事件生存期分别为未达到和133 d(P=0.03),中位总生存时间分别为未达到和210 d(P=0.01). 在急性髓系白血病中,... | zh-cn |
pair_32027246 | To compare the gene mutational spectrum between elderly and young adults with acute myeloid leukemia(AML) based on next generation sequencing(NGS). The specimens of 250 AML patients in first affiliated hospital of Zhengzhou University from January 2018 to November 2018 were collected and analyzed retrospectively. The m... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 基于二代测序的老年和年轻成人急性髓系白血病患者突变基因谱比较. 比较基于二代测序(NGS)的老年和年轻急性髓系白血病(AML)患者突变基因谱,探讨老年AML的分子生物学特点. 回顾性分析2018年1月至2018年11月在郑州大学第一附属医院进行了基于22个基因突变谱的NGS检测初治AML(非急性早幼粒细胞白血病)患者的突变基因数据,并比较老年(≥60岁)和年轻(<60岁)AML患者之间的差异. 250例患者常见突变频率依次为NPM1(22.4%)、FLT3-ITD(18.8%)、NRAS(17.2%)、DNMT3A(14.4%)、TET2(11.6%)、IDH2(9.6%)、CEBPA双突变(8.8%)、CEBPA单突变(8.4%)... | zh-cn |
pair_32027247 | To investigate the clinical efficacy, related side-effectt and long-term survival condition of Philadelphia chromosome positive acute lymphoblastic leukemia (Ph<sup>+</sup> ALL) patients treated with second generation TKI dasatinib and chemotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HS... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 达沙替尼联合化疗序贯异基因造血干细胞移植治疗Ph染色体阳性急性淋巴细胞白血病的临床分析. 观察第二代酪氨酸激酶抑制剂(TKI)达沙替尼联合化疗并序贯异基因造血干细胞移植(allo-HSCT)治疗Ph染色体阳性急性淋巴细胞白血病(Ph<sup>+</sup> ALL)患者的临床疗效、治疗相关副反应及长期生存情况. 选取2012年1月至2018年9月于北京大学第一医院确诊为Ph<sup>+</sup> ALL,并应用达沙替尼联合化疗及序贯allo-HSCT治疗的19例患者, 收集病历资料并进行相关数据统计分析. 19例患者中,男性10例,女性9例,中位年龄29(3-48)岁。P190阳性14例,P210阳性5例,3例为复杂染色体核型,3... | zh-cn |
pair_32027248 | To investigate the clinical manifestations and laboratory features of B-ALL patients with EP300-ZNF384 fusion gene positive, so as to improve the understanding of this subtype disease. The clinical data of 3 B-ALL patients with EP300-ZNF384 fusion gene positive admitted in Department of Hematology, the first medical ce... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 伴EP300-ZNF384融合基因阳性的急性B淋巴细胞白血病临床特点分析. 探讨与分析对EP300-ZNF384融合基因阳性的急性B淋巴细胞白血病(B-ALL)患者的临床及实验室特征,以期提高对此少见类型疾病的认识. 收集并回顾性分析本院自2017年2月至2018年2月收治的37例B-ALL的临床资料,对检出EP300-ZNF384融合基因阳性3例患者的临床、实验室特征及治疗情况进行深入分析. 8.1%的B-ALL患者检测出EP300-ZNF384融合基因。3例患者R显带核型分析均为正常核型,在免疫分型上均表达有CD13或CD33等髓系标志。3例患者均对于传统化疗敏感. EP300-ZNF384阳性的B-ALL可能是一类具有独特临床... | zh-cn |
pair_32027252 | To investigate the effects of IRF1 on the homeostasis and differentiation of K562 cells. Three different vectors were constructed to screen the best strategy for IRF1 overexpression. The effect of IRF1 on cell proliferation and apoptosis was explored by cell count and apoptotic surface marker detection. Likely, the eff... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 过表达干扰素调节因子IRF1重塑K562细胞的稳态特征. 考察干扰素调节因子IRF1对K562细胞稳态及分化的影响. 构建3种不同的过表达载体以筛选实现IRF1增强表达的最佳方式;通过细胞计数考察IRF1对细胞增殖的影响;通过凋亡标记分析IRF1对药物诱导凋亡的影响;通过分化标记分析IRF1对红系分化的影响;通过RT-qPCR初步探索IRF1的调控机制. 利用P2A-T2A方式构建的单一开放阅读框具有最明显的表达效果,是实现IRF1增强表达的最佳方式;细胞计数结果发现,IRF1对K562的增殖无明显影响;Annexin V和7-AAD联合标记发现,IRF1过表达显著抑制细胞的凋亡进程;流式结果显示,IRF1同样可进一步提升CD71<... | zh-cn |
pair_32027253 | To investigate the expression and significance of B and T lymphocyte weakening factor (BTLA) in patients with chronic myelomonocytic leukemia (CMML). Real-time PCR was used to detect the expression of BTLA and its ligand HVEM mRNA in 11 patients with chronic myelomonocytic leukemia and 11 normal donors. Flow cytometry ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 慢性粒-单核细胞白血病患者BTLA及其配体HVEM的表达及其意义. 探讨 B 和 T 淋巴细胞弱化因子(BTLA)在慢性粒单核细胞白血病(CMML)患者中的表达情况及其意义. 采用real-time PCR方法检测11例慢性粒单核细胞白血病患者和11 例正常供者外周血BTLA及其配体HVEM mRNA的表达情况;流式细胞术检测外周血T淋巴细胞及γδ T 细胞表面BTLA及其HVEM的表达. CMML患者外周血BTLA及其配体HVEM mRNA表达水平的中位值分别为0.009% 和559.4%,明显低于正常对照组(0.053% 和1031%)(P<0.001);外周血T淋巴细胞表面BTLA其配体HVEM的表达水平较正常对照组无明显差异... | zh-cn |
pair_32027255 | To explore the clinical characteristics and therapeutic efficacy of patient with adult acute lymphoblastic leukemia(ALL). Seventy-seven ALL patients diagnosed in the first affiliated hospital of Zhengzhou University from 2018 to 2019 were selected. The immunotyping, fusion gene and gene mutation were detected by flow c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 成人急性淋巴细胞白血病患者的临床特点与疗效分析. 结合白血病的免疫分型、融合基因和突变基因探讨初治急性淋巴细胞白血病(ALL)患者的临床特点和治疗反应. 选择2018-2019年郑州大学第一附属医院确诊的77例成人ALL患者,应用流式细胞术、实时荧光定量PCR技术(RT-PCR)、二代测序技术(NGS)进行免疫学及分子生物学检测. 77例ALL患者中, B-ALL患者66例,T-ALL患者9例。CD7、cCD3对于T-ALL最具有诊断价值,CD19、cCD79a对于B-ALL最具有诊断价值,另外,B-ALL中高表达CD58、CD123。RT-PCR检测出了BCR-ABL(20.8%)、MLL-AF4(5.19%)、E2A-PBX1(... | zh-cn |
pair_32027256 | To investigate the mutation rate and distribution of Homo sapiens neuroblastoma RAS viral oncogene homolog (NRAS) gene in the patients with acute myeloid leukemia. The genomic DNA of bone marrow was screened by polymerase chain reaction (PCR) and sequencing for NRAS mutations. At the same time, the mutations of ASXL1, ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | NRAS基因突变在成人急性髓系白血病中的表达及临床意义. 探讨神经母细胞瘤RAS病毒致癌基因(NRAS)在急性髓系白血病患者中的突变率及分布情况. 提取骨髓基因组DNA,采用聚合酶链式反应技术(polymerase chain reaction, PCR)扩增目的基因片段,应用基因测序分析NRAS基因突变情况。同时检测FLT3-ITD、DNMT3A、NPM1、CEBPA、TET2、IDH2、ASXL1及c-KIT基因突变情况,分析其与NRAS突变之间的关系. 108例初发急性髓系白血病患者中共发现NRAS突变11例,突变率为10.2%,其中G12D 6例、G13D 3例、G61K 2例。突变组患者外周血白细胞计数偏高(P<0.05)... | zh-cn |
pair_32027257 | To provide clinical basis for the diagnosis and treatment of chronic neutrophilic leukemia (CNL) and to provide possible molecular targets for the treatment. By summarizing the clinical data of 14 patients with CNL, the clinical characteristics, gene mutation types and possible prognostic factors were analyzed. Among t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 慢性中性粒细胞白血病患者的临床特征及预后分析. 为慢性中性粒细胞白血病(chronic neutrophilic leukemia,CNL)诊断和治疗提供临床依据,为其治疗提供可能的分子靶标. 总结14例CNL患者的临床资料,分析其临床特点、基因突变类型及影响患者预后的因素. 14例CNL患者中男性(9例)多于女性(5例),中位年龄57岁。CSF3R突变检出率为92.86%(13/14),包括12例(85.71%)T318I突变和1例Y799X突变,另1例未检测到CSF3R突变;42.86%(6/14)患者检测到ASXL1突变,且均为无义突变,分别为R693X(4例)和E705X(2例);14.29%(2/14)患者检测出SETBP... | zh-cn |
pair_32027259 | To analyze the correlation of the minimal residual disease level with the prognosis of the AML patients with NPM1 gene mutation positive after chemotherapy. The clinical data of 112 newly diagnosed adult AML patients with positive NPM1 gene were collected and retrospectively analyzed. The correlation of the transcripts... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | NPM1突变阳性AML患者化疗后早期微小残留病水平与预后的关系. 分析NPM1基因突变阳性的急性髓系白血病(AML)患者经化疗后,早期微小残留病水平与患者预后状况的相关性. 收集本院112例NPM1基因突变阳性的初诊成人AML患者的临床资料,分析患者化疗后NPM1基因突变转录本水平与患者预后状况的相关性. 在112例AML患者中,初诊时NPM1基因突变转录本中位水平为83.68%(5.86%-486.57%),FLT3-ITD突变阳性44例(39.29%),染色体核型异常22例(19.64%),完全缓解96例(85.71%);多因素Logistic回归分析结果发现,初始诱导治疗方案和白细胞计数(WBC)与完全缓解密切相关(P<0.0... | zh-cn |
pair_32027263 | To analyze the expression level of miR-429 in patients with acute lymphoblastic leukemia(ALL) and its clinical prognostic value. One hundred and Twenty-six patients with ALL treated in our hospital from April 2016 to February 2018 were selected, and 100 healthy persons in the same period were selected as control group.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 急性淋巴细胞白血病患者miR-429表达水平及其预后价值. 分析急性淋巴细胞白血病(ALL)患者miR-429表达水平及其临床预后价值. 选择2016年4月-2018年2月在本院血液科诊治的ALL患者126例,并选择同期100例体检健康者作为对照,收集研究对象的骨髓单个核细胞,采用RT-PCR检测单个核细胞的miR-429水平,同时分析miR-429表达水平与患者临床特征及疗效的相关性,采用Kaplan-Meier法及多因素Cox回归模型分析miR-429水平与ALL患者预后的相关性. ALL患者中,miR-429相对水平为2.47±0.07,显著高于对照组(P<0.05)。miR-429水平与ALL患者的白细胞水平(r=0.994... | zh-cn |
pair_32027264 | To analyze relation of ASXL2 gene mutation with the clinical characteristics, prognosis and C-KIT gene mutation in acute myeloid leukemia (AML) patients with AML1-ETO fusion gene. The clinical data of 63 primary AML patients with AML1-ETO fusion gene were collected and retrospectively analyzed. The mutation of ASXL2 ge... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | ASXL2基因突变与伴AML1-ETO融合基因的AML患者的临床特征、预后及C-KIT基因突变的关系. 分析ASXL2基因突变与伴AML1-ETO融合基因的急性髓系白血病(AML)患者的临床特征、预后及C-KIT基因突变的关系. 收集并回顾性分析本院63例伴有AML1-ETO融合基因的初发AML患者的临床资料,根据PCR直接测序技术对患者ASXL2基因突变情况进行检测。比较ASXL2基因突变(A组)患者与无突变患者(B组)的临床特征、c-kit基因突变率及预后状况. 63例患者中,发生ASXL2基因突变8例(12.70%)。A组患者初诊时外周血血红蛋白水平较B组患者明显下降(P<0.01),2组性别、年龄、骨髓原始细胞比例、淋巴结肿... | zh-cn |
pair_32027265 | To study the expression level of TGFβ1 and VEGF gene in patients with acute myeloid leukemia (AML) and its clinical prognostic value. Seventy-eight AML patients treated in our hospital from July 2016 to September 2018 were selected. After isolation of bone marrow mononuclear cells from the patients, the levels of TGFβ1... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | TGFβ1及VEGF基因在急性髓系白血病患者中的表达水平及其临床预后价值. 研究TGFβ1及VEGF基因在急性髓系白血病(AML)患者中的表达水平及其临床预后价值. 选取2016年7月至2018年9月间在本院接受治疗的78例AML患者,分离患者骨髓单个核细胞后,采用RT-PCR实验检测样本TGFβ1及VEGF基因水平,并分析TGFβ1及VEGF基因表达与AML患者临床特征的相关性;采用Kaplan-Meier评估患者的OS及EFS;采用Cox风险比例模型分析患者的预后危险因素. AML患者TGFβ1基因相对表达水平为0.32±0.04,显著低于对照组(P<0.05)。VEGF基因相对表达水平为2.65±0.15,显著高于对照组(P<... | zh-cn |
pair_32027266 | To analyze the relationship between cytogenetic changes and the progression in the patients with chronic myeloid leukemia (CML) during the treatment with tyrosine kinase inhibitor (TKI). The chromosome G banding of 150 patients with CML treated in our hospital, was carried out to analyze the karyotype by the 24 h short... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | CML患者在TKI治疗过程中的细胞遗传学变化与病程演进的关系分析. 分析慢性髓系白血病(CML)患者在酪氨酸激酶抑制剂(TKI)治疗过程中的细胞遗传学变化与病程演进的关系. 对本院收治的150例初诊CML患者,通过骨髓细胞24 h短期培养法或直接法,行染色体G显带技术核型分析;经ABL激酶区点突变检测,分析细胞遗传学变化与其病程演进的相关性. 间接荧光原位杂交技术检测结果发现,150例患者BCR-ABL融合基因均为阳性,其中费城(Ph)染色体阳性142例(94.67%),阴性8例(5.33%);142例Ph染色体阳性患者中,初诊Ph阳性且伴有额外染色体异常14例(9.86%),变异易位4例(2.82%),标准易位t(9;22)(q3... | zh-cn |
pair_32027267 | To investigate the proliferation, differentiation potential and autophagic mechanism HL-60 cells via ULK1 protein targeted by Haishengsu extracted from Tegillarca granosa. The HL-60 cells were divided into five groups: Haishengsu of 10,100,1000 mg/L-treated group, all-trans retinoic acid (ATRA) 5 μmol/L-treated group a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 海生素靶向ULK1蛋白诱导HL-60细胞分化机制的研究. 探讨泥蚶提取物海生素通过靶向调控ULK1蛋白诱导HL-60细胞增殖和分化潜能,以及自噬机制. 实验分为海生素10、100和1000 mg/L处理组、全反式维甲酸(ATRA)5 μmol/L处理组和对照组,共5组,分别培养HL-60细胞12、24、48和72 h,采用MTT法检测各组细胞增殖率,采用流式细胞术检测细胞分化成熟标志分子CD11b和CD15的表达,采用Western blot法检测自噬分子ULK1、LC-3蛋白的表达. 海生素100和1000 mg/L处理HL-60细胞48和72 h,HL-60细胞增殖率均显著低于ATRA组(P<0.05)和海生素10 mg/L组和... | zh-cn |
pair_32027268 | To investigate the effect of sorafenib combined with decitabine on the viability and apoptosis of diffuse large B-cell lymphoma cell line OCI-LY1 and its mechanism. Sorafenib at 1.5μmol/L or decitabine at 25μmol/L was used to treat the cells alone or in combination. The viability of OCI-LY1 cells was detected by CCK8 a... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 索拉非尼联合地西他滨协同作用诱导弥漫大B细胞淋巴瘤凋亡的机制研究. 探讨索拉非尼联合地西他滨对弥漫大B细胞淋巴瘤OCI-LY1细胞活力和凋亡的影响及其机制. 采用索拉非尼(1.5 μmol/L)和地西他滨(25 μmol/L)单独或联合作用于OCI-LY1细胞,CCK8法检测细胞存活率,并使用碘化丙啶(Propidium Iodide,PI)染色,通过荧光显微镜观察阳性细胞比例。通过流式细胞术检测细胞增殖能力及细胞内活性氧水平。采用Western blot检测凋亡相关蛋白的表达水平. 与对照组相比,索拉非尼和地西他滨单独或联合处理均可抑制细胞增殖,激活氧自由基产生,最终诱导细胞凋亡,并且索拉非尼和地西他滨具有协同作用。通过Weste... | zh-cn |
pair_32027270 | To investigate the expression and clinical significance of microRNA-195 in patients with diffuse large B cell lymphoma(DLBCL). Sixty patients with DLBCL were selected from nearly four years in our hospital, and at the same time 30 healthy people with physical examination of the same period and with the same age in our ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | microRNA-195在弥漫大B细胞淋巴瘤患者中的表达及临床意义. 探讨微小RNA 195(miR-195)在弥漫大B细胞淋巴瘤(DLBCL)患者中的表达及其临床意义. 选取本院近4年诊治的60例DLBCL患者,并选取同时期同年龄段于本院行健康体检的健康人群30例作为对照,采用实时荧光定量PCR(qRT-PCT)分别测定两组患者miR-195的表达量,分析其表达与患者临床病理特征及患者生存时间的关系. miR-195在DLBCL患者中的表达量较对照组显著降低(P<0.001);miR-195的表达水平与DLBCL患者肿瘤直径、IPI指数评分及Ann Arbor分期密切相关;高表达miR-195的DLBCL患者总体生存时间显著高于低... | zh-cn |
pair_32027273 | To investigate the effect of atractylenolide I on proliferation and apoptosis of U266 cells, and anti-multiple myeloma effect of bortezomib. Bortezomib, bortezomib combined atractylenolide I and atractylenolide I at different concentrations were added into U266 cells respectively, cellular proliferation toxicity was ev... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 白术内酯I能诱导U266细胞凋亡和增强硼替佐米的作用. 探讨白术内酯I对U266细胞增殖和凋亡的作用及其对硼替佐米抗多发性骨髓瘤的作用. 分别将不同浓度的白术内酯I、硼替佐米以及硼替佐米+白术内酯I作用于U266细胞,并应用CCK-8法检测细胞增殖活性,Annexin V-FITC/PI染色及流式细胞术检测细胞凋亡率及细胞周期,应用RT-PCR及Western blot分别检测目标基因Caspase-3、Caspase-9、BCL-2、BAX、JAK2、STAT3及IL-6的mRNA及相应蛋白的表达. 白术内酯I能呈浓度依赖性抑制U266细胞的增殖(r=-0.98)和促进细胞凋亡(r=0.99),调控线粒体介导的凋亡途径;联合用药能... | zh-cn |
pair_32027274 | To investigate the expression and clinical significance of long non-coding RNA PRAL in patients with multiple myeloma(MM). Clinical data of 60 MM patients and 60 healthy people with the same age(as controls) were selected. Real time-quantitative fluorescence PCR (RT-qPCR) was used to determine the expression levels of ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 长链非编码RNA PRAL在多发性骨髓瘤患者中的表达及其临床意义. 探讨长链非编码RNA PRAL(LncRNA PRAL)在多发性骨髓瘤(MM)患者中的表达及其临床意义. 收集本院收治的60例MM患者临床数据资料,并选取同年龄段健康人群60例作为对照,采用实时荧光定量PCR(RT-qPCR)分别测定2组患者血清LncRNA PRAL的表达量,分析其表达与患者临床病理特征及患者预后的关系. LncRNA PRAL在MM患者中的表达较健康者显著下降(F=13.294,P<0.001)。LncRNA PRAL的表达与MM患者D-S分期及ISS分期相关;高表达LncRNA PRAL的MM患者PAD疗效显著提高,中位生存时间显著延长(P<0... | zh-cn |
pair_32027275 | To analyzed the prognostic value of serum free light chain kappa/lambda ratio detection combined with immunofixation electrophoresis in multiple myeloma (MM) patients. 72 patients with MM treated in our hospital from January 2017 to December 2018 were selected. Serum free light chain kappa/lambda ratio (sFLCR) and immu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 血清游离轻链κ/λ比值联合免疫固定电泳在多发性骨髓瘤患者预后评估中的价值. 分析血清游离轻链κ/λ比值联合免疫固定电泳在多发性骨髓瘤患者预后评估中的价值. 选取2017年1月-2018年12月期间本院收治的多发性骨髓瘤(MM)患者72例,分别检测患者的血清游离轻链κ/λ比值(sFLCR)及免疫分型,比较不同患者的临床特点及生存时间。采用COX回归分析患者预后的影响因素. 72例患者中高sFLCR组38例,低sFLCR组34例。与低sFLCR组患者相比,高sFLCR组患者DS分期升高,患者β2-MG、Scr水平升高,Hb水平下降,差异均具有统计学意义(P<0.05)。72例患者中IgG型40例(55.56%), IgA型 27例(37... | zh-cn |
pair_32027276 | To investigate the distribution of peripheral blood lymphocytes and natural killer (NK) cells, and its influence on the prognosis of patients with myelodysplastic syndromes (MDS). The lymphocytes proportion, absolute lymphocyte counts (ALC), NK cell proportion and absolute NK cell counts (ANKC) as well as the related d... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 初诊骨髓增生异常综合征患者自然杀伤细胞分布特点及与预后的相关性. 分析骨髓增生异常综合征(MDS)患者外周血淋巴细胞及自然杀伤(NK)细胞的分布及其对预后的影响. 回顾性分析2013年-2017年就诊的95例初诊MDS患者的淋巴细胞比例和绝对值(ALC),NK细胞比例和绝对值(ANKC)及相关临床资料,分析各指标与预后的关系,应用曲线下面积(AUC)评估预后模型的精确度. 与低ALC的MDS患者相比,初诊MDS患者中,ALC≥0.885×10<sup>9</sup>/L的患者治疗后的总体反应(OR)率较高(66.7% vs 35.8%)(P<0.01);治疗有效的患者,ALC较初诊时显著增高(0.959±0.510)×10<sup>... | zh-cn |
pair_32027277 | To investigate the mutation of RUNX1 gene in patients with myelodysplastic syndrome (MDS) and its correlation with other gene mutations and some clinical parameters. The mutations of RUNX1, DNMT3A, TET2, IDH1/2, NPM1, FLT3-ITD and C-KIT in 170 patients with MDS were detected by direct and indirect sequencing of genomic... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 骨髓增生异常综合症患者RUNX1基因突变分析. 探讨骨髓增生异常综合症(MDS)患者中RUNX1基因突变情况,以及与其他基因突变和部分临床参数间的相关性. 采用基因组DNA-PCR扩增产物直接测序法检测170例MDS患者中RUNX1、DNMT3A、TET2、IDH1/2、NPM1、FLT3-ITD、C-KIT突变情况. 170例患者中RUNX1基因突变检测率为13.5%(23/170),其他基因突变率依次为:TET2(11.2%,19/170)、DNMT3A(9.4%,16/170)、NPM1(8.2%, 14/170)、IDH2(4.1%,7/170)、FLT3-ITD(2.9%,5/170)、IDH1(1.7%,3/170)、c... | zh-cn |
pair_32027278 | To investigate the expression characteristics and clinical value of OTC4 gene in patients with myelodysplastic syndrome (MDS). Sixty-five patients with MDS were selected from June 2017 to April 2018, and 39 healthy subjects were selected as control group. Mononuclear cells were isolated from bone marrow collected by as... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | OTC4基因在骨髓增生异常综合征患者中的表达水平及临床意义. 探讨OTC4基因在骨髓增生异常综合征(MDS)患者中表达特征及临床价值. 选自2017年6月-2018年4月在本院诊治的65例MDS患者,同时选择39例在本院体检健康者作为对照组,通过无菌穿刺收集受试者的骨髓后分离单个核细胞,RT-PCR实验检测MDS患者OTC4基因水平, Western blot实验检测MDS患者OTC4蛋白水平,Kaplan-Meier法绘制MDS患者生存曲线。Cox多因素分析患者独立的预后因素. OTC4基因在MDS患者中的相对表达量显著高于对照组(P<0.05)。MDS患者中OTC4蛋白表达水平高于对照组(P<0.05)。OTC4基因表达与MDS... | zh-cn |
pair_32027280 | To study the level and clinical value of Th17 cell subset in the peripheral blood of the patients with aplastic anemia (AA). Eighty-five patients with aplastic anemia in our hospital from May 2017 to February 2018 were selected. Among them, 51 patients with poor curative effect were enrolled in group A. and the 34 pati... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 再生障碍性贫血患者外周血Th17细胞亚群水平及临床意义. 研究再生障碍性贫血(AA)患者外周血Th17细胞亚群水平及其临床价值. 选择2017年5月-2018年2月在我院治疗的85例再生障碍性贫血患者,其中51例患者疗效较差,纳入A组;34例患者疗效较好,纳入B组。同时选取35名体检健康者作为对照。采用ELISA实验分析患者血清IL-17、IL-6、IL-4及IFN-β水平;采用流式细胞术分析患者外周血Th17细胞亚群水平;采用RT-PCR分析淋巴细胞RORγt和 STAT3的mRNA表达水平;采用Western blot分析淋巴细胞RORγt和 STAT3蛋白水平. A组与B组患者的性别、年龄、WBC、并发症的差异无统计学意义(P... | zh-cn |
pair_32027281 | To analyze the clinical efficacy and side effects of reduced-dose of cyclophosphamide combined cyclosporine A for severe aplastic anemia(SAA) children. Ten pediatric patients with SAA from January 2008 to May 2012 were enrolled. All the patients were treated with reduced dose of cyclophosphamide combined cyclosporine A... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 减低剂量环磷酰胺联合环孢菌素A治疗重型再生障碍性贫血患儿的疗效分析. 观察减低剂量环磷酰胺联合环孢菌素A治疗重型再生障碍性贫血(以下简称重型再障)患儿的疗效及副反应. 自2008年1月到2012年5月就诊的10例重型再障患儿均接受减低剂量的环磷酰胺联合环孢菌素A治疗,具体应用剂量为环磷酰胺30 mg/(kg·d)×4 d,环孢菌素A起始剂量为4 mg/(kg·d), 后根据血药浓度调整用药剂量,使环孢菌素A谷浓度在150 ng/ml以上. 中位随访时间为 100 (6-126) 个月,10例患儿中有4例获得完全缓解,3例获得部分缓解,总有效率为70%,其余3例无效。1例难治的重型再障患儿在应用环磷酰胺治疗后25个月进展为阵发性血红蛋... | zh-cn |
pair_32027282 | to explore the value of capillary electrophoresis in screening β- thalassemia of children, and to establish the cutoff values of HbA2 and HbF in our laboratory. The data of hemoglobin capillary electrophoresis and genetic diagnosis of β- thalassemia from 886 examined children were retrospectively analyzed. The cutoff v... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 毛细管电泳筛查小儿β地中海贫血的应用研究. 探讨毛细管电泳在小儿β地中海贫血筛查中的价值,并建立本实验室HbA2、HbF的截断值. 分析886例血红蛋白电泳的结果以及它们对应的β地中海贫血基因结果,通过ROC曲线确定HbA2、HbF的截断值. HbA2筛查轻型β地中海贫血的截断值是3.65%,特异度是0.996,敏感度是0.995。 HbF筛查轻型β地中海贫血的截断值是1.45%,特异度是0.751、敏感度是0.675;由此还检出了1例Codon5(CCT→C)突变、1例 SEA-HPFH β缺失、1例-28(A→G)合并IVS-Ⅰ-128(T→G)双重杂合突变、1例尚未见报道47bp的β缺失. 毛细管电泳在筛查小儿β地中海贫血中具... | zh-cn |
pair_32027284 | To investigate the preventive and therapeutic effects of endothelial progenitor cells on monocrotaline-induced hepatic vein occlusion disease in mice. C57BL/6 mice were randomly divided into 3 groups: saline group (n=15), monocrotaline group (n=15), and endothelial progenitor cell infusion group (n=15). Liver function ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 内皮祖细胞对野百合碱诱导的肝静脉闭塞病的防治作用研究. 探讨内皮祖细胞对野百合碱诱导的小鼠肝静脉闭塞病的防治作用. 将C57BL/6小鼠随机分为3组:生理盐水组(n=15)、野百合碱组(n=15)、野百合碱+内皮祖细胞输注组(n=15)。灌胃后d 8检测各组小鼠肝功能(TBIL、ALT、AST)、肝脏指数及TNF-α、IL-6水平; HE 染色及免疫组织化学染色观察肝血窦内皮细胞、肝中央静脉内皮细胞及肝细胞的损伤情况,Masson 染色了解肝脏纤维化的程度. 在光学显微镜下可见野百合碱组小鼠肝脏中至重度肝血窦内皮细胞、中央静脉内皮细胞损伤及肝小静脉淤血;Masson染色可见中至重度肝中央静脉、肝血窦纤维化。野百合碱+内皮祖细胞组在光... | zh-cn |
pair_32027285 | To investigate the therapeutic efficacy of using decitabine as maintenance therapy for patients with relapsed MDS/AML and as prophylactic therapy for patients with high-risk AML after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Clinical data of 10 patients with MDS/AML from November 2016 to May 2018... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 地西他滨治疗移植后复发MDS/AML及高危AML患者的临床疗效分析. 探讨异基因造血干细胞移植(allo-HSCT)后复发的骨髓增生异常综合征/急性髓系白血病(MDS/AML)患者应用含地西他滨的化疗方案缓解后继续维持治疗的效果及高危AML在allo-HSCT后进行预防性输注地西他滨的疗效. 对2016年11月至2018年5月于本院行allo-HSCT术后的10例MDS/AML患者进行回顾性分析,包括AML 4例,MDS 2例,MDS转化的AML(t-AML)4例。10例患者中移植后复发8例,高危AML移植后应用地西他滨预防2例。复发组患者应用地西他滨+化疗达完全缓解(CR)后,继续应用地西他滨维持治疗;预防组患者在移植后30至45... | zh-cn |
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