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pair_32027287 | To investigate the clinical significance of minimal residual disease (MRD) monitoring by multiparameter flow cytometry (MFC) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute leukemia. 81 cases of patients with AL treated with allo-HSCT in Department of Hematology, the First Affiliated Hosp... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 多参数流式细胞术检测移植前微小残留病灶在急性白血病患者异体造血干细胞移植治疗中的意义. 探讨异基因造血干细胞移植前多参数流式细胞术(multi-parameter flow cytometry,MFC)检测微小残留病(minimal residual disease,MRD)对于急性白血病患者预后的临床意义. 选取并回顾性分析2015年7月至2018年7月在重庆医科大学附一院血液内科首次进行异体造血干细胞移植(allo-HSCT)的急性白血病患者81例,其中移植前达形态学完全缓解的急性白血病患者79例,未达形态学完全缓解2例,分析完全缓解组(CR)与未完全缓解组(NCR)患者移植预后的差异,根据移植前的MRD情况分为阳性组(MRD<... | zh-cn |
pair_32027290 | To investigate the effect of bone marrow stromal cell glycosyltransferase B4GALT1 expression on hematopoietic cell proliferation and its upstream regulation mechanism. B4GALT1 was overexpressed in human bone marrow stromal cell line HS5, which was then co-cultured with acute myeloid leukemia cell line KG1a. And its eff... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 骨髓基质细胞中B4GALT1对与其共培养的人急性髓系白血病细胞株增殖的影响. 探讨骨髓基质细胞糖基转移酶B4GALT1的表达对造血细胞增殖的影响及其上游调控机制. 在人骨髓来源基质细胞HS5中过表达B4GALT1,并与急性髓系白血病细胞KG1a共培养,采用流式细胞术检测其对造血细胞增殖的影响;应用双荧光素酶报告基因检测、实时荧光定量PCR和蛋白免疫印迹法对调控基质细胞B4GALT1表达的上游转录因子进行预测和验证. HS5中过表达B4GALT1能显著促进共培养体系中KG1a的增殖。基质细胞中B4GALT1表达与上游c-Jun表达呈正相关,并通过JNK/c-Jun抑制剂进行了验证. 糖基转移酶及其引起的相应糖基化差异在造血微环境中起到... | zh-cn |
pair_32027291 | To investigate the related factors influencing plasma transfusion efficacy so as to improve the plasma transfusion efficiency. According to the clinical symptoms and the laboratorial results, the patients were divided into transfusion efficient and inefficient groups. A total of13090.8 units of plasma were transfused t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 4 423例次血浆输注效果的影响因素分析研究. 探讨影响血浆输注效果的相关因素,以期进一步提高患者血浆输注有效率和临床输注的合理性. 根据输血后患者临床症状改善情况和实验室凝血检测值将患者分为血浆输注有效和无效2组。对4 423例患者的基本临床资料和13 090.8 U的血浆输注过程中涉及的主要因素如输血浆前PT、APTT、血浆种类、保存时间、输注血浆体重比(kg/ml)等进行分类统计分析. 外科监护室患者血浆用量最多,占总血浆输注比例最大(30.36%),人均用血浆量最大的科室为心外科(3.96 U)。从输注效果上看,不同年龄组患者的输血效果有差别(P<0.001),<18岁组患者血浆输注有效率(53%)高于18-60岁和<60岁... | zh-cn |
pair_32027293 | To study the single nucleotide polymorphisms (SNPs) in promoter region of the Jk gene and its allele frequency as well as distribution characteristics in the Chinese Han nationality population. 127 blood samples containing 8 Jk(a-b-) and 119 samples (as control) taken randomly from voluntary blood donors of Chinese Han... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Kidd血型基因启动子区域单核苷酸多态性及其等位基因频率与分布特征研究. 分析中国汉族人群Jk基因启动子区单核苷酸多态性(SNP)及其等位基因频率与组合分布特征. 选取127例血液标本,包括8例Jk(a-b-)标本与119例随机选择的中国深圳地区汉族健康无偿献血者血样,利用血清学方法与尿素溶血试验鉴定Kidd血型表型,并对Jk基因启动子与外显子1-11及其侧翼的区域扩增后测序,分析序列信息. 8例Jk(a-b-)标本全部携带JkB/JkB等位基因,并且分属于2种中国汉族人群常见的Jk<sub>null</sub>基因型:6例为IVS5-1g>a,2例为896G>A。另外,对于Jk(a-b-)标本启动子区域的序列分析发现3个SNP:-... | zh-cn |
pair_32027294 | To analyze the clinical characteristics, pathological features, treatment response and prognosis of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), so as to provide reference for reducing clinical misdiagnosis and treatment regimens. The clinical, pathological features, treatment regimens and treatm... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 母细胞性浆细胞样树突细胞肿瘤患者的临床特点. 分析母细胞性浆细胞样树突细胞肿瘤(blastic plasmacytoid dendritic cell neoplasm,BPDCN)患者的临床特点、病理特征、治疗方案、治疗反应及预后,为减少临床漏诊误诊、治疗选择提供参考. 回顾性分析中南大学湘雅二医院2013年1月1日-2019年5月30日诊断治疗的9例BPDCN患者的临床、病理特征、治疗方案及疗效反应. 9例BPDCN患者最常见的受累部位是皮肤;病理特点均为真皮层受累,免疫组织化学阳性率最高的指标为CD4、CD43、LCA、CD123、VIM,均为100%;其次为CD56、 CD68、TDT、CD5、PAX-5、 CD3、CD8、... | zh-cn |
pair_32027296 | Abstract Currently, hematopoietic stem cell (HSC) transplantation is widely used in the therapy of hematological malignancies, non-malignant refractory anemia, genetic diseases and certain tumors with satisfactory therapeutic efficacy. HSC sources used for transplantation include bone marrow, mobilized peripheral bloo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 体外产生可移植的人造血干细胞的研究进展. 造血干细胞(hematopoietic stem cell,HSC)移植被广泛应用于恶性血液病、非恶性衰竭性血液疾病以及非血液系统疾病(遗传性疾病和某些实体瘤)的治疗,并取得了良好疗效。临床上常用的移植HSC源有骨髓、动员的外周血及脐带血。但是,由于这些组织中HSC含量很少,及组织相容性抗原特异的供者稀缺等问题,导致许多病人无法获得足够量的组织相容性匹配的HSC。因此,如何通过体外培养获得满足临床需要的HSC已成为近年来学者们研究的热点问题。目前体外产生HSC的主要来源为人多能干细胞(human pluripotent stem cell,hPSC),包括人胚胎干细胞(human embry... | zh-cn |
pair_32027297 | Abstract The Latent infection cansed by Epstein-Barr virus (EBV) closely relates with the occurrence and development of several kinds of lymphoma. Exosome (EXO) is functional bilayer membrane structural corpuscles which are secreted by cells contain proteins, lipids and nucleic acids. In recent years, researches showe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | EB病毒潜伏感染致淋巴瘤细胞外泌体分泌和功能异常的研究进展. EB病毒(EBV)潜伏感染与多种淋巴系统肿瘤发生发展有着密切关系。外泌体(EXO)是细胞分泌的包含蛋白质、脂质、核酸等的功能性双层膜结构小体。近几年来有研究表明,EXO在肿瘤发生发展过程中起着重要作用,故对比EBV阴性和EBV阳性淋巴瘤细胞在EXO分泌数量与内容物方面的差异,了解EXO对淋巴瘤细胞和免疫细胞生物学行为的影响,对EBV潜伏感染通过外泌体途径影响淋巴瘤发生发展机制的研究具有重要意义。本综述重点阐述EBV潜伏感染对淋巴瘤细胞EXO分泌数量、内容物及其功能的影响. | zh-cn |
pair_32027298 | Abstract Chimetic antigen receptor T cells (CAR-T) are a kind of novel killer cells derived from autogenous or allogeneic T cells targeting the tumor specific antigens by gene engineering transpormation. The CAR-T cells possess the advantages of high specificity, high efficiency and non-MHC restriction, thus achieving... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 流式细胞术在CAR-T细胞治疗中的应用进展. 嵌合抗原受体T细胞(chimeric antigen receptor T cell,CAR-T)是通过基因工程技术将自体或异体T细胞改造成针对肿瘤特异性抗原的新型杀伤细胞,具有特异性强、效率高、非MHC限制等优点,在复发/难治性血液系统肿瘤和部分实体瘤中取得了良好的治疗效果。CAR-T细胞制备流程包括细胞分离和纯化、活化和分化、基因修饰、体外扩增、表型质控、保存和回输。近年来,随着流式细胞术的迅速发展,使其广泛应用于CAR-T细胞治疗的各个环节,包括治疗前筛查、体外制备和回输后监测,并在其创新优化过程中发挥着重要的作用. | zh-cn |
pair_32027299 | Abstract In recent years, development of the targeted drugs according to the biological characteristics of tumors have provided more treatment options for tumor patients. It was found that the overactivation or abnormality of B cell receptor (BCR) signal pathway closely related to the occurrence and development of var... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | BTK抑制剂在B细胞肿瘤治疗中的研究进展. 近年来,根据肿瘤生物学特性研发的靶向药物已为肿瘤患者提供更多的治疗选择。有研究发现,B细胞受体(BCR)信号通路的过度活化或异常与多种B细胞肿瘤如慢性淋巴细胞白血病(CLL)、套细胞淋巴瘤(MCL)等的发生发展密切相关。BTK(Bruton酪氨酸激酶)作为BCR通路上的关键激酶,抑制其活性可产生明显的抗肿瘤效应。目前已研发的BTK抑制剂包括第一代Ibrutinib、第二代Acalabrutinib等,可靶向抑制BTK及其下游信号通路,对多种B细胞肿瘤如CLL,部分非霍奇金淋巴瘤(NHL)等具有重要治疗价值。然而其毒副作用及耐药问题亦逐渐显现,有效的药物联合治疗方案已显示出一定的临床活性。现... | zh-cn |
pair_32027300 | Abstract The minimal residual disease (MRD) is the origin element that caused the relapse and drug resistance of hematological malignancies, the immune cells play a great role to clear MRD. A variety of immune cells have anti-tumor effects. However, tumor cells antagonize anti-tumor effects by reprogramming of constit... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 外泌体通过发挥免疫调控作用影响血液肿瘤细胞生物学特性的研究进展. 微小残留病灶(minimal residual disease,MRD)是导致血液肿瘤复发及耐药的根源因素,而免疫细胞在清除微小残留病灶中发挥重要作用。多种免疫细胞具有抗肿瘤作用,但肿瘤细胞可以通过改造肿瘤微环境抑制免疫细胞的抗肿瘤作用。在肿瘤微环境中多种细胞包括免疫细胞、间充质细胞和癌细胞都可分泌外泌体(exosome)。最新研究认为,血液肿瘤细胞分泌的外泌体承载的“货物”及表面配体可调控NK细胞功能(包括迁移、活化、增殖、分泌以及NKG2D的表达)、巨噬细胞功能(迁移及分泌)及树突状细胞功能(成熟及递呈);并且调节PD-L1、CCR2的表达、CCL2的分泌及向抑制... | zh-cn |
pair_32027301 | Abstract Although the majority of patients with Hodgkin's lymphoma (HL) can be cured with upfront treatment, but a fraction of patients with advanced disease will experience refractory or recurrence leading to poor prognosis. How to treat these patients is the focus of current research. High-dose chemotherapy combined... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 复发/难治性霍奇金淋巴瘤治疗策略的研究进展. 大部分的霍奇金淋巴瘤(HL)目前已经可以达到治愈,但仍有一小部分患者出现复发难治且预后较差的情况,如何治疗这类患者是目前的研究热点。大剂量化疗桥接自体造血干细胞移植是复发难治性HL的标准挽救方案。近年来,挽救治疗联合靶向药物Brentuximab vedotin、免疫检查点抑制剂Nivolumab和Pembrolizumab等,在早期的临床试验中展现了一定的疗效。另外,伊马替尼、依维莫司等药物也有良好的应用前景。本文将就复发/难治性霍奇金淋巴瘤治疗策略的研究进展作一综述. | zh-cn |
pair_32027303 | Abstract Langerhans cell histiocytosis (LCH) is a disease originated from bone marrow dendritic cells, and classified as a tumor by the discovery of a recurrent somatic BRAF-V600E point mutation in the RAS-RAF-MEK-ERK signaling pathway. The clinical manifestations of LCH are mainly granulomatous lesions composed of cl... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 朗格汉斯细胞组织细胞增生症的研究进展. 朗格汉斯细胞组织细胞增生症(LCH)是一种起源于骨髓树突状细胞的疾病,因RAS-RAF-MEK-ERK信号通路中重现性体细胞BRAF-V600E点突变的发现,故将其归为肿瘤性疾病。LCH的临床表现广泛,以克隆性病理组织细胞组成的肉芽肿病变为特征,根据病变部位及浸润风险器官的不同分为单系统疾病、无风险器官浸润的多系统疾病和风险器官浸润的多系统疾病。通过免疫组化病理性树突状细胞特异性标志CD1α<sup>+</sup>和/或CD207<sup>+</sup>确诊,根据风险分层以制定联合化疗和靶向治疗的方案及强度,预后与风险器官浸润、初始治疗反应和BRAF突变相关。由于发病率低且缺乏系统性认识,临床... | zh-cn |
pair_32027387 | To develop a validated tool to measure nursing and midwifery documentation burden. While an important record of care, documentation can be burdensome for nurses and midwives and may remove them from direct patient care, resulting in decreased job satisfaction, associated with decreased patient satisfaction. The amount ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 开发有效工具来衡量护理和助产工作的文件记载负担。 背景: 虽然文件记载属于一项重要的护理记录工作,但其对护士和助产士来说可能很麻烦,并可能会使他们脱离直接的病人护理,导致工作满意度降低,进而病人满意度下降。在人员合理化导致病床临床医师人数减少的情况下,文件记载数量正在增加。尚无任何工具可用来衡量人员对临床文件记载负担的看法。 设计: 调查开展,然后进行两轮内容验证(2019年4月和5月)。 方法: 根据文献资料,采用6个分量表的条目,对文件记载负担的重要方面展开28个条目的调查。经临床和学术护士及助产士组成的专家小组进行两轮评估后,对条目(I-CVI)、分量表(根据分量表的平均S-CVI)以及总体的内容效度指数(平均S-CV... | zh-cn |
pair_32030779 | To construct a model addressing the pathways from baseline diabetes distress, attribution of peer reactions, parenting style and 3-month self-management to 6-month glycated haemoglobin levels in adolescents with type 1 diabetes. A prospective design was adopted. A total of 177 adolescents aged 10-19 with type 1 diabete... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 构建模型,说明患有1型糖尿病青少年从基准时间糖尿病困扰、同龄人反应归因、父母教养方式以及3个月自我管理到6个月糖化血红蛋白水平的转变途径。 设计: 采用前瞻性设计。 方法: 共选取台湾四所医院177名10-19岁患有1型糖尿病的青少年作为研究对象。于基准时间收集糖尿病困扰、同龄人反应归因和父母教养方式情况数据,于第3个月收集自我管理情况数据,于第6个月收集糖化血红蛋白水平数据。数据于2015年5月至2016年6月期间收集。 结果: 基准时间糖尿病困扰和3个月的自我管理对6个月时的糖化血红蛋白水平有直接影响。基准时间同龄人反应归因会直接影响基准时间糖尿病困扰以及3个月的自我管理情况;同时,它还通过3个月的自我管理对6个月时的糖... | zh-cn |
pair_32030792 | To define digital health services that have been studied among chronically ill adolescents and to describe e-health coaching elements that may have an impact on transition outcomes. Systematic review without meta-analysis. MEDLINE (Ovid), Pub Med, Scopus and CINAHL on 28 May 2018. Peer-reviewed articles published betwe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 明确已开展研究的针对患有慢性病青少年的数字化医疗服务,并说明可能影响过渡结果的电子医疗指导要素。 设计: 不包括荟萃分析的系统评估。 数据来源: 于2018年5月28日通过MEDLINE(Ovid)、Pub Med、Scopus和CINAHL数据库进行检索。 评估方法: 对于2008年1月至2018年5月期间发表的同行评审文章按照《Cochrane干预措施系统评价手册》的要求进行评估,并根据《系统评估和荟萃分析优先报告条目》进行报告。 结果: 共纳入12项随机对照试验。干预措施在持续时间和内容方面存在显著差异。包括人力和社会支持在内的电子指导对过渡结果产生了积极影响。将数字化医疗服务用于日常护理有助于提供高效便利的护理工作。... | zh-cn |
pair_32030796 | To determine the prevalence and magnitude of medication errors and their association with patients' sociodemographic and clinical characteristics and nurses' work conditions. An observational, analytical, cross-sectional and ambispective study was conducted in critically ill adult patients. Data concerning prescription... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 确定用药失误的发生率、程度及其与患者社会人口学、临床特征以及护士工作条件之间的关系。 设计: 对成年危重患者进行观察性、分析性、横向和双向性研究。 方法: 从病历中回顾性收集处方错误相关数据,并通过对护士在用药期间的直接观察,发现用药失误。此类数据于2015年4月至7月期间收集。 结果: 在90例患者使用的961种药物中共发现有650个处方错误(平均错误率7【SD 4.1】),发生率为47.1%(95%CI 44-50)。最为常见的一类错误是漏开处方药。重症监护病房住院时间是导致出现漏开失误的一大相关风险因素(OR2.14;1.46-3.14:p< .01)。52例患者使用的249种药物中共发现有294个用药失误(平均失误率... | zh-cn |
pair_32030942 | To summarize the clinical application and research progress in unicompartmental knee arthroplasty (UKA). The literature related to UKA in recent years was reviewed and the emerging indications, implant options, comparisons between other surgical techniques, and recent advances were summarized. Clinical studies show tha... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 总结膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)的临床应用及研究进展。. 广泛查阅近年国内外 UKA 相关文献,从 UKA 新出现的手术指征、假体类型选择、与其他术式对比以及最新进展等方面进行总结分析。. 临床研究表明 UKA 具有创伤小、恢复快、术后并发症少等诸多优点。目前该手术适应证有所扩展,体质量指数>25 kg/m <sup>2</sup>、年龄<60 岁、髌股关节炎及前交叉韧带功能不良不再属于手术禁忌证。UKA 术中假体类型的选择需要充分考虑患者情况。近年,临床逐渐开展的机器人辅助 UKA 可有效改善手术疗效,提高患者术后满意度,降低术后并发症。. 随着手术技术、假体材料... | zh-cn |
pair_32030943 | To compare differences in the maintenance of cervical curvature after anterior cervical surgery between zero-profile and self-locking intervertebral cage and plate-cage construct (PCC). A clinical data of 100 patients with single-segment cervical disc herniation who were treated with anterior cervical discectomy and fu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨零切迹椎间融合器与钛板-椎间融合器(plate-cage construct,PCC)系统在颈椎前路术后颈椎曲度维持方面的差异。. 回顾分析 2015 年 1 月—2016 年 1 月收治并行颈前路椎间盘切除减压融合术治疗的 100 例单节段颈椎间盘突出症患者临床资料,其中 50 例采用零切迹椎间融合器(A 组),50 例采用 PCC 系统(B 组)。两组患者性别、年龄、骨密度、病变节段、病程及术前疼痛视觉模拟评分(VAS)、日本骨科协会(JOA)评分、C <sub>2~7</sub> 颈椎曲度、节段 Cobb 角、相邻椎体高度等一般资料比较,差异均无统计学意义( <i>P</i>>0.05),具有可比性。记录两组手术时间及术中... | zh-cn |
pair_32030944 | To identify effect of quantitative indicators of ilium height on approach of percutaneous endoscopic lumbar discectomy (PELD) treatment in patients with L <sub>5</sub>, S <sub>1</sub> lumbar disc herniation. A retrospective study between May 2014 and March 2016 was conducted, including 100 patients with disc herniation... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 寻找有效确定 L <sub>5</sub>、S <sub>1</sub> 椎间盘突出症患者行经皮椎间孔镜技术(percutaneous endoscopic lumbar discectomy,PELD)时影响穿刺、器械放置及镜下操作的量化指标。. 回顾性分析 2014 年 5 月—2016 年 3 月 100 例术前拟行 PELD 治疗的单节段 L <sub>5</sub>、S <sub>1</sub> 椎间盘突出患者,其中 66 例(A 组)成功行 PELD 手术,余 34 例(B 组)因髂骨等周围骨性结构的影响导致穿刺、置管或镜下操作失败,改行其他手术方式。通过分析两组患者术前腰椎正位(包括双侧髂骨)X 线片,创新性地提出髂高... | zh-cn |
pair_32030945 | CT three-dimensional reconstruction technology was used to simulate the placement of the lumbar cortical bone trajectory (CBT), to determine the starting point and direction of the screw trajectory. Between February 2017 and April 2018, 24 patients with lumbar CT were selected as the study object. There were 7 males an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 通过 CT 三维重建技术模拟腰椎皮质骨螺钉(cortical bone trajectory,CBT)植钉,明确植钉起点及方向。. 选取 2017 年 2 月—2018 年 4 月 24 例患者腰椎 CT 作为研究对象。其中男 7 例,女 17 例;年龄 37~68 岁,平均 50.4 岁。将患者 CT DICOM 格式数据导入 Mimics 16.0 软件中,建立腰椎三维模型;运用软件建立直径 5 mm 圆柱体模拟腰椎 CBT,根据植钉方案不同将研究分为 A、B、C 3 组,其钉道轨迹分别经过椎弓根峡部上缘、内侧缘、下缘。将模拟螺钉与腰椎相交部分标记为感兴趣区(region of interest,ROI)并生成蒙板,应用 Mim... | zh-cn |
pair_32030947 | To investigate the effectiveness of the Evans lateral lengthening calcaneal osteotomy (E-LLCOT) in treatment of talocalcaneal coalition (TCC) with hindfoot valgus deformity. Between January 2014 and October 2017, 10 patients (13 feet) of TCC with hindfoot valgus deformities underwent E-LLCOTs. There were 6 males (8 fee... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨 Evans 跟骨外侧延长术治疗距跟联合合并后足外翻畸形的疗效。. 2014 年 1 月—2017 年 10 月,采取 Evans 跟骨外侧延长术治疗 10 例(13 足)距跟联合合并后足外翻畸形患者。男 6 例(8 足),女 4 例(5 足);年龄 13~18 岁,平均 15.8 岁。病程 10~14 个月,平均 11.5 个月。患侧跟骨外翻、前足外展、足弓低平。疼痛部位:跗骨窦 4 足、距跟联合 5 足、踝关节 4 足。Silverskiold 试验腓肠肌腱膜紧张 3 例(4 足),跟腱挛缩 7 例(9 足)。术前美国矫形外科足踝协会(AOFAS)踝与后足评分为(46.54±9.08)分,行走 1 km 后疼痛视觉模拟评分(... | zh-cn |
pair_32030946 | To evaluate the effectiveness of lesion clearance combined with Ilizarov technique for the treatment of tophi in first metatarsophalangeal (MTP) joint with bone defect. Between July 2016 and June 2018, 14 cases of tophi in the first MTP joint with bone defect were treated by lesion clearance combined with Ilizarov tech... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨病灶清除联合 Ilizarov 技术治疗第 1 跖趾关节痛风石合并骨缺损疗效。. 2016 年 7 月—2018 年 6 月,采用病灶清除联合 Ilizarov 技术治疗 14 例第 1 跖趾关节痛风石合并骨缺损患者。男 12 例,女 2 例;年龄 22~60 岁,平均 39.3 岁。病程 5~15 年,平均 11.2 年。痛风石体积 2.5 cm×2.7 cm×2.2 cm~5.2 cm×2.9 cm×2.4 cm。X 线片显示骨缺损长度 2.0~4.6 cm,平均 3.4 cm。术前疼痛视觉模拟评分(VAS)为(7.6±0.9)分,美国矫形外科足踝协会(AOFAS)评分为(47.5±4.3)分,简明健康调查量表(SF-36 ... | zh-cn |
pair_32030948 | To evaluate the effectiveness of total scapular arthroplasty after total scapulectomy for scapular tumors. A clinical data of 17 patients with scapular tumors treated with total scapulectomy and total scapular arthroplasty between January 2010 and December 2017 were retrospectively reviewed. There were 9 males and 8 fe... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 总结人工全肩胛骨置换术治疗肩胛骨肿瘤患者的疗效。. 回顾分析 2010 年 1 月—2017 年 12 月采用全肩胛骨切除联合人工全肩胛骨置换术治疗的 17 例肩胛骨肿瘤患者临床资料。男 9 例,女 8 例;年龄 13~64 岁,平均 34.4 岁。软骨肉瘤 7 例、骨肉瘤 3 例、尤文肉瘤 2 例、高级别肉瘤 1 例、多形性未分化肉瘤 1 例、纤维肉瘤 1 例、浆细胞瘤 1 例、骨巨细胞瘤 1 例。Enneking 外科分期:3 期 1 例,ⅠB 期 8 例,ⅡB 期 8 例。Malawer 分型:ⅢB 型 11 例,ⅣB 型 5 例,ⅥB 型 1 例。肿瘤体积 11.0 cm×7.5 cm×6.0 cm~18.5 cm×18.0... | zh-cn |
pair_32030949 | To summarize the effectiveness of two-stage reverse total shoulder arthroplasty for treating postoperative deep infection after internal fixation of the proximal humeral fracture. Between June 2014 and January 2018, 17 patients with deep infection and humeral head necrosis or bone nonunion after internal fixation of pr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 总结二期反式肩关节置换治疗肱骨近端骨折内固定术后感染的疗效。. 2014 年 6 月—2018 年 1 月,收治 17 例肱骨近端骨折内固定术后感染伴肱骨头坏死或骨不连患者。男 8 例,女 9 例;年龄 52~78 岁,平均 63.8 岁。初次内固定术后 19~66 个月确诊发生感染,平均 34.8 个月。关节腔液体微生物培养 14 例阳性、3 例阴性。术前 Constant 评分为(36.41±8.65)分,美国肩肘外科协会(ASES)评分为(31.06±7.43)分,疼痛视觉模拟评分(VAS)为(7.29±0.99)分。肩关节前屈(45.88±12.46)°,外展(42.18±12.31)°,外旋(16.76±4.92)°,内旋... | zh-cn |
pair_32030950 | To investigate the method and effectiveness of transosseous suture <i>in situ</i> technique in repairing anterior cruciate ligament (ACL) avulsion injury for the multiple ligament injuries with knee dislocation (MLIKD). The clinical data of 27 patients (27 knees) with MLIKD between September 2010 and April 2016 were an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨膝关节多发韧带损伤脱位(multiple ligament injuries with knee dislocation,MLIKD)中采用穿骨原位缝合修复前交叉韧带(anterior cruciate ligament,ACL)止点撕脱损伤的方法及疗效。. 回顾分析 2010 年 9 月—2016 年 4 月收治并符合选择标准的 27 例(27 膝)MLIKD 患者临床资料。其中男 21 例,女 6 例;年龄 24~60 岁,平均 42 岁。致伤原因:交通事故伤 9 例,重物砸伤 9 例,运动扭伤 6 例,高处坠落伤 3 例。受伤至手术时间 1~19 d,平均 10.8 d。ACL 股骨止点撕脱损伤 20 例、胫骨止点撕脱损伤... | zh-cn |
pair_32030951 | To compare the cost changes of total knee arthroplasty (TKA) before and after the cancellation of medical consumables addition, so as to provide reference for the national medical reform policy. The patients treated with TKA between September 2018 and February 2019 were admitted as objects of study, and 372 of them met... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 比较医用耗材加成取消前后人工全膝关节置换术(total knee arthroplasty,TKA)费用,为国家医疗政策改革提供参考。. 以 2018 年 9 月—2019 年 2 月接受 TKA 治疗的患者作为研究对象,其中 372 例符合标准纳入研究。根据医用耗材取消加成时间节点(2018 年 12 月 24 日)分为取消前和取消后两组,各 186 例。收集患者资料,包括性别、年龄、住院时间、疾病分类,以及各项治疗费用(诊疗费、检查费、化验费、材料费、麻醉费、床位费、护理费、手术费、药费和其他),分析取消加成前后各项费用及构成比变化情况。. 两组患者性别、年龄及疾病分类构成比较,差异均无统计学意义( <i>P</i>>0.05)... | zh-cn |
pair_32030952 | To discuss the clinical application and effectiveness of autologous costal cartilage transplantation in the repair of upper lip depression in the secondary repair of cleft lip. The clinical data of 10 patients of secondary repair of upper lip depression with cleft lip by autologous costal cartilage transplantation betw... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨自体肋软骨移植在唇裂二期修复上唇凹陷中的临床应用效果。. 回顾分析 2017 年 1 月—2019 年 1 月采用自体肋软骨移植修复的 10 例唇裂二期上唇凹陷患者临床资料。其中男 7 例,女 3 例;年龄 18~33 岁,平均 24 岁。双侧唇裂 8 例,单侧唇裂 2 例,均于 2~3 岁行早期唇裂修补术。术前及术后即刻采用定位侧位照片测量分析法,对患者上唇软组织侧貌变化进行定量分析,测量指标包括:软组织面型角(G-Sn-Pg’),鼻唇角(Cm-Sn-UL),颏唇角(UL-LL-Pg’),上唇最突点到审美平面的距离(UL-E),额部最高点、上唇最突点在眶耳平面上的投影距离(G-UL),上唇突度(ULP)。. 术后 1 例出现切... | zh-cn |
pair_32030953 | To explore the effect of icariin on early steroid-induced osteonecrosis of the femoral head in rabbits. Fifty mature New Zealand rabbits (weighing, 2.5-3.0 kg) were randomly divided into control group ( <i>n</i>=10), model group ( <i>n</i>=20), and experimental group ( <i>n</i>=20). The rabbits of model and experimenta... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨淫羊藿苷对激素诱导的兔早期激素性股骨头坏死干预效果。. 50 只成年新西兰兔(体质量 2.5~3.0 kg)随机分为对照组( <i>n</i>=10)、模型组( <i>n</i>=20)及实验组( <i>n</i>=20)。模型组和实验组采用脂多糖联合甲泼尼龙注射制备早期激素性股骨头坏死模型;实验组首次注射甲泼尼龙开始每日灌服淫羊藿苷药液 1 次,对照组及模型组灌服等量生理盐水,连续 6 周。于 6 周后取左侧股骨头行大体观察;Micro-CT 扫描观察骨小梁微结构,测量骨小梁相对体积(bone volume to total volume,BV/TV)、骨小梁数量(trabecular number,Tb.N)、骨小梁厚度(t... | zh-cn |
pair_32030955 | To investigate the effect of circulating estrogen level on the outcome of free fat grafting in nude mice. Eighteen female nude mice aged 6-8 weeks (weighing, 20-25 g) were randomly divided into 3 groups ( <i>n</i>=6). The nude mice in the ovariectomized group were treated with ovariectomy. The nude mice in the high est... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨循环雌激素水平对裸鼠颗粒脂肪移植转归的影响。. 取 6~8 周龄雌性裸鼠 18 只(体质量 20~25 g),随机分为 3 组( <i>n</i>=6)。去势组采用卵巢切除术制备去势裸鼠模型,高雌激素组及正常雌激素组仅作相同切口进入腹膜后,不切除卵巢组织。术后高雌激素组每 3 天灌胃雌二醇(0.2 mg/g)1 次,共持续 30 d;其他两组同时间点等量 PBS 灌胃。术后 30 d 取 3 组裸鼠尾静脉血经 ELISA 检测雌二醇浓度后,将接受抽脂术的健康女性捐赠的颗粒脂肪注入裸鼠头皮下(0.3 mL/只)。脂肪移植后 8 周取材大体观察、称重后,制备切片行 HE 染色、CD31-围脂滴蛋白荧光染色、解耦联蛋白 1(uncou... | zh-cn |
pair_32030956 | To explore the possibility of constructing tissue engineered adipose by adipose tissue derived extracellular vesicles (hAT-EV) combined with decellularized adipose tissue (DAT) scaffolds, and to provide a new therapy for soft tissue defects. The adipose tissue voluntarily donated by the liposuction patient was divided ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨人脂肪源细胞外囊泡(human adipose tissue derived extracellular vesicle,hAT-EV)联合脱细胞脂肪组织支架(decellularized adipose tissues,DAT)构建组织工程脂肪的可能性,为临床上软组织缺损修复提供新方案。. 将吸脂手术患者自愿捐赠的脂肪组织分为 2 份,1 份脂肪组织进行脱细胞处理,并采用组织学(HE、Masson 染色)、扫描电镜观察,Ⅰ、Ⅳ 型胶原及层粘连蛋白免疫组织化学染色和 Western blot 检测进行表征。另 1 份脂肪组织使用去外泌体的完全培养基孵化 48 h,离心收集培养基上清并使用超高速离心法获取 hAT-EV。使用透射电... | zh-cn |
pair_32030960 | To review the research progress of total endoscopic minimally invasive technique in treating cervical nerve root canal stenosis (CNRCS). The related literature at home and abroad was extensively reviewed. The research history, current situation, research progress, advantages and disadvantages of minimally invasive trea... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 综述全内镜下微创治疗颈神经根管狭窄(cervical nerve root canal stenosis,CNRCS)的研究进展。. 广泛查阅近年国内外相关文献,总结全内镜下微创治疗 CNRCS 的研究历史、现状、进展以及优缺点。. 随着近几年脊柱外科全内镜微创技术的不断发展,CNRCS 手术治疗方法也不断革新。与传统开放手术比较,全内镜下微创治疗 CNRCS 在获得较好临床疗效的同时最大限度保留了术后颈段稳定性,减少了对颈椎活动度的影响以及相关手术并发症的发生,是一种有效的微创技术。. 全内镜下微创治疗 CNRCS 取得了一定效果,仍需完善,但其利远大于弊,有望成为治疗 CNRCS 不可或缺的手段之一。. | zh-cn |
pair_32030961 | To review the research progress in the treatment of proximal humeral fractures with fibular allograft and locking plate. The literature about the treatment of proximal humeral fractures with fibular allograft and locking plate was reviewed and analyzed from the aspects such as the biomechanics, imaging prognosis, and c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 对同种异体腓骨移植联合锁定钢板治疗肱骨近端骨折的研究进展进行综述。. 广泛查阅国内外同种异体腓骨移植联合锁定钢板治疗肱骨近端骨折的相关文献,从生物力学、影像学预后以及临床预后等多个方面进行总结分析。. 与单纯应用锁定钢板相比,同种异体腓骨移植联合锁定钢板治疗肱骨近端骨折,可以对肱骨近端提供有效的内侧支撑,并增加内固定系统强度;同时可以更好地维持术后肱骨颈干角以及肱骨头高度,恢复更好的术后肩关节活动度及肩关节功能,并且不会增加相关并发症发生风险。. 同种异体腓骨移植联合锁定钢板可能成为一种新的有效的治疗肱骨近端骨折手术方式,但目前中远期随访结果报道有限,移植腓骨的长期预后仍然不确定,同时该治疗方式可能引起的长期潜在不良反应仍不够明确。... | zh-cn |
pair_32030962 | To summarize the research progress of the greater tubercle fixation and the rotator cuff repair in humeral head replacement. The literature about proximal humerus fracture and humeral head replacement in recent years was extensively consulted and analyzed. The greater tubercle fixation and the attached rotator cuff rep... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 总结肱骨头置换术中肱骨大结节固定及肩袖修复方式的研究进展。. 广泛查阅近年来国内外肱骨头置换以及肱骨近端骨折治疗相关文献,并进行总结分析。. 肱骨大结节固定及其附着肩袖修复对肱骨头置换术后肩关节功能有明显影响。为促进肱骨大结节愈合,学者就肱骨大结节固定方法及材料进行了研究,但针对不同固定方法及材料缺少随机对照研究及统一的评分量表,同时由于病例数有限,难以进行客观比较。. 肱骨大结节良好复位固定是肱骨头置换术获得较好疗效的重要因素。但就肩关节功能恢复方面,肱骨头置换时一期修复肩袖比大结节复位固定更重要。. | zh-cn |
pair_32033513 | the National Health Commission of the People's Republic of China publish the guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection (trial version 5) .With the awareness and understanding of the disease, the guidelines have been revised for recognize, treat, and prevent diseases. Then, wh... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 国家卫生健康委员会(以下简称卫健委)发布了《新型冠状病毒感染的肺炎诊疗方案(试行第五版)》,随着对疾病不断地认识和了解,诊疗方案也随之进行修订。诊疗方案(以下简称方案)的发布指导我们认识疾病、治疗疾病、预防疾病。那么,卫健委发布的第五版诊疗方案较第四版具体更新了哪些内容,本文进行了解读。. | zh-cn |
pair_32033514 | Infection with 2019 Novel Coronavirus (2019-nCoV) is mainly transmitted by respiratory droplets, airborne transmission and direct contact. However, conducting bronchoscopy on patients with 2019-nCoV is a high-risk procedure in which health care workers are directly exposed to the virus, and the protection and operation... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 2019新型冠状病毒(2019 novel coronavirus,2019-nCoV)感染感染主要通过呼吸道飞沫传播、空气传播及接触传播,结合支气管镜操作的特点,制订了当前疫情下支气管镜诊疗操作的流程、要求及注意事项。进行支气管镜诊疗操作时须严格执行传染病防控相关标准,强调了支气管镜检查不作为诊断新冠感染采样的常规手段,在按要求做好防护的基础上,严格掌握支气管镜诊疗适应证,如非病情急需,建议暂缓检查。. | zh-cn |
pair_29658230 | To prepare a polyclonal antibody against human lysozyme-like protein 4 (LYZL4) expressed in the prokaryotic system and identify the distribution of LYZL4 in the testis. The full-length cDNA of LYZL4 was cloned into the pET32a plasmid and the expression of the recombinant LYZL4 (rLYZL4) was induced by IPTG. The rLYZL4 w... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 以原核表达的人源类溶菌酶蛋白4(LYZL4)为免疫原制备多克隆抗体,检测LYZL4在睾丸组织中的定位,为阐明其生理功能提供依据。 方法: 将 LYZL4编码基因克隆于原核表达载体pET32a,IPTG诱导重组LYZL4(rLYZL4)表达。分别使用Ni-NTA树脂和甲壳素亲和层析纯化rLYZL4,采用双层琼脂平板扩散法检测 杀菌活性。以Ni-NTA树脂纯化产物为免疫原制备兔抗rLYZL4多克隆抗体,通过ELISA测定抗体效价,Western印迹检测抗体特异性后,检测LYZL4蛋白在人体各组织的分 布及其在精子和精浆中存在情况,免疫组化确认LYZL4在人睾丸组织中的定位。 结果: 原核表达系统可有效表达rLYZL4,其对溶壁微... | zh-cn |
pair_29658231 | To investigate whether androgens can regulate the expression of eNOS in rat corpus cavernosum through AKT3, PIK3CA, CALM, and CAV1 and influence erectile function. Thirty-six 8-week-old male SD rats were randomly divided into groups A (4-week control), B (6-week control), C (4-week castration), D (6-week castration), E... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究雄激素是否通过蛋白激酶B-3(AKT3)、I类磷脂酰肌醇-3-激酶的p110催化亚单位(PIK3CA)、钙调蛋白(CALM)、小窝蛋白1(CAV1)调控大鼠阴茎海 绵体组织内皮型一氧化氮合酶(eNOS)的表达,并影响阴茎勃起功能。方法: 8周龄健康雄性SD大鼠36只,随机均分为6组:4周对照组(A组)、6周对照组(B组)、4 周去势组(C组)、6周去势组(D组)、4周去势+睾酮(T)替代组(E组)、6周去势+T替代组(F组)。C、D、E、F组切除双侧睾丸及附睾,1 d后E、F组隔日1次丙酸 睾酮3 mg/kg皮下注射,其余各组等量植物油皮下注射。4周后(A、C、E组)、6周后(B、D、F组)分别检测各组大鼠海绵体内压(I... | zh-cn |
pair_29658232 | To observe the effects of swimming plus medication on the expressions of cytokines in rats with chronic abacterial prostatitis (CAP). Forty healthy adult male SD rats were randomly divided into five groups of equal number, normal control, CAP model control, medication, exercise therapy, and exercise + medication. The C... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 观察游泳运动与药物综合治疗对慢性非细菌性前列腺炎(CAP)大鼠前列腺组织中TNF-α、IL-1β和IL-6水平的影响。 方法: 成年雄性健康 SD大鼠40只,随机分为正常对照组、CAP模型对照组、药物治疗组、运动治疗组及运动与药物综合治疗组,每组8只。注射消痔灵制备CAP大鼠模型,造模期7 d后药物 治疗组和综合治疗组每天给予前列舒通胶囊水溶液(0.016 g/ml)灌胃治疗(剂量为20 ml/kg);运动治疗组和综合治疗组每天于固定时间进行1次游泳运动,第1天35 min/次,每天递增5 min,直至50 min/次,每周6 d,持续4周;正常对照组、CAP模型对照组及运动治疗组给予无菌生理盐水灌胃(剂量同上)。于治疗过程... | zh-cn |
pair_29658233 | To investigate the anti-prostate cancer (PCa) effect of roemerine in vitro and in vivo in the mouse model of PCa. We detected the effects of roemerine on the proliferation, apoptosis and migration of PCa cells DU145, LNCaP, PC-3 and 22RV1, screened out the sensitive cell line and constructed a tumor-bearing model in mi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 构建体外、体内模型,探讨罗默碱抗前列腺癌活性。方法: 检测罗默碱对多种前列腺癌细胞(DU145、LNCaP、PC-3和22RV1)增殖、凋亡和迁移的影 响,筛选敏感肿瘤细胞系,构建裸鼠荷瘤模型,进一步验证罗默碱的体内抗肿瘤药效。 结果: 罗默碱对DU145、LNCaP、PC-3和22RV1细胞增殖和迁移均具有不同程 度的抑制作用,对其细胞凋亡亦具有不同程度的诱导作用,其中以LNCaP细胞最为敏感。裸鼠荷LNCaP肿瘤模型中,罗默碱单独干预组肿瘤重量[(1.99±0.95) g ]显著低于对照组[(2.95±1.04) g],P<0.01;而高剂量罗默碱(30 mg/kg)和紫杉醇联合干预组肿瘤重量[(0.90±0.16) g... | zh-cn |
pair_29658234 | To investigate the application of Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) in the treatment of early-stage prostate cancer. We retrospectively analyzed the clinical data about 10 cases of early-stage prostate cancer treated by RS-RARP with the Da Vinci Robot Surgical System from September to Octob... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨保留Retzius间隙的机器人辅助腹腔镜下根治性前列腺切除术的初步应用。方法: 2016年9~10月,入组早期前列腺癌10例,实施保留Retzius间隙的 机器人辅助腹腔镜下根治性前列腺切除术。结果: 10例手术均获成功,手术切缘均为阴性。完成手术时间170~250(196±25) min,术中出血量150~500 (260±128) ml,术后住院日6~7 d,术后拔除导尿管时间14 d,仅1例患者存在尿失禁(每天1块尿垫),术后1个月完全恢复。结论: 保留Retzius间隙的机器人辅 助腹腔镜下根治性前列腺切除术安全、有效、可靠,有利于早期恢复控尿。. | zh-cn |
pair_29658235 | To investigate the effect of modified Bianchi (single incision in the midline of the scrotum) orchiopexy (MBO) versus that of traditional surgery in the treatment of median or low cryptorchidism. Eighty-two children with median or low cryptorchidism were treated from February 2013 to February 2014, 46 (53 testes) by MB... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨改良Bianchi(阴囊中缝切口)睾丸下降固定术与传统(腹股沟联合阴囊切口)睾丸下降固定术的优缺点。方法: 2013年2月至2014年2月收治的 所有82例中低位隐睾患儿中,随机对其中46例(53侧睾丸)行改良Bianchi睾丸下降固定术作为观察组;传统方法即经腹股沟联合阴囊切口治疗36例(40侧)作为对照组。 比较2组手术时间、术后并发症等方面的差异。结果: 观察组与对照组患儿的手术时间分别为(25±6) min和(35±4) min,两组比较差异有统计学意义 (P<0.01);经过1~2年的随访比较,均未出现睾丸萎缩情况;观察组患儿出现3例睾丸上缩情况,对照组出现2例术后睾丸上缩,发生率的差异没有统计学意义;术 后均... | zh-cn |
pair_29658236 | To evaluate the safety, efficacy and tolerability of China-made sildenafil citrate (Jinge) in the treatment of ED. We conducted a multi-center, randomized, double-blind and placebo-controlled clinical trial among 222 ED patients in five urological or andrological clinics of China. The patients were randomly assigned to... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 评价国产枸橼酸西地那非(金戈)治疗男性勃起功能障碍(ED)的安全性、有效性和耐受性。方法: 采用多中心、随机、双盲、安慰剂对照研究方法 ,在国内5家医院泌尿外科或男科门诊纳入222例ED患者,随机分为西地那非组(111例)和安慰剂组(111例),进行为期8周的临床治疗观察。以国际勃起功能问卷( IIEF)评分、性交成功率作为有效性评价指标,以不良事件发生率作为安全性评价指标。结果: 西地那非组和安慰剂组患者年龄分别为(47.20±11.32)岁和( 46.67±13.08)岁(P>0.05),ED病因分别为心理性(27.93% vs 23.42%)、器质性(21.62% vs 29.73%)和混合性ED(50.45% vs ... | zh-cn |
pair_29658237 | To study the correlation of the gene expressions of Chk1 and Chk2 with sperm concentration and motility. According to sperm concentration and motility (percentage of progressively motile sperm), we divided 80 semen samples into four groups of equal number: normal control, oligozoospermia (OS), asthenospermia (AS), and ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究精子中细胞周期检测点激酶1/2(Chk1和Chk2)基因的表达对精子浓度及活力的影响。方法: 将精液样本根据精子浓度和活力(前向运动精子百 分率)分为正常对照组、少精子症组、弱精子症组和少弱精子症组,每组20例。分别检测各组精子DNA碎片指数(DFI)、精子存活率,采用RT-PCR和Western印迹方法 分别检测各组精子Chk1、Chk2的表达。 结果: ①4组DFI分别为21.24±6.93、19.67±7.64、21.52±6.92、19.28±11.55,无显著差异 (P>0.05);4组精子存活率分别为(83.48±9.87)%、(63.86±9.16)%、(50.45±16.99)%、(39.21±15.74... | zh-cn |
pair_29658238 | To investigate the routine semen parameters and sperm morphological indexes of the patients with partial globozoospermia (PGZ). We included in this study 100 infertile males with PGZ and another 180 non-PGZ infertile men as controls. According to the proportion of round-headed sperm (RHS) in the semen, we classified th... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 分析部分型圆头精子症患者精液常规参数及精子形态。方法: 选取 2013年1月至2016年5月100例部分型圆头精子症患者作为病例组,对照组为非圆 头精子症的不育患者180例。根据精液中圆头精子所占比例不同将病例组分成5组:1组(25%~40%)、2组(41%~55%)、3组(56%~70%)、4组(71%~85%)、5组 (86%~99%),根据WHO《人类精液检查与处理实验室手册》第5版标准对其进行精液常规分析,包括精子浓度、活动率、前向运动精子百分率,及对不同畸形精子进行 计数并计算畸形精子指数(TZI)及精子畸形指数(SDI)。结果: 病例组与对照组的精子活动率[(35.76±24.88)% vs (62.03±10.... | zh-cn |
pair_29658239 | To investigate the association of the polymorphisms of the gene of estrogen receptor α 1 (ESR1) with the risk of hypospadias in children of Northeast China. This study included 95 hypospadias patients aged 3.2±0.6 years and 105 children aged 3.1±0.7 years as normal controls. Using PCR and gene sequencing, we determined... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究雌激素受体α基因(ESR1) rs2077647和rs6932902位点多态性与中国东北地区儿童尿道下裂遗传易感性之间的关联。方法: 选取尿道下裂组儿 童95例,年龄(3.2±0.6)岁;对照组儿童105例,年龄(3.1±0.7)岁。采用PCR和基因测序检测所有研究对象ESR1基因 rs2077647和rs6932902位点的基因型, 进行病例对照研究。结果: 经PCR和基因测序检测,尿道下裂组和正常对照组rs2077647和rs6932902位点基因型及等位基因分布频率,差异有统计学意义(χ2=8.552 ,χ2=16.251,P<0.05);尿道下裂组rs2077647位点单核苷酸多态性的C等位基因比例显著高于正常对... | zh-cn |
pair_29658240 | To explore the relationship between the clinical and genetic features of a short-statured azoospermia male with the karyotype of 45,X. Using GTG-banded chromosome analysis, we performed karyotyping for a 150 cm-high infertile male with azoospermia and investigated the presence and location of the genes on the Y chromos... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨1例身材矮小合并无精子的45,X不育男性的临床表型与核型的关系。方法: 采用外周血染色体G显带进行核型分析,PCR及FISH对Y染色体上SRY、 AZF等基因进行检测和定位。结果: 外周血染色体G显带分析显示该患者核型为45,X,add(14)(p11)。PCR结果显示该患者SRY基因存在,AZFa、AZFb、AZFc、AZFd全部 缺失。FISH结果证实该患者Y染色体短臂及着丝粒区存在,且易位至14号染色体短臂,Y染色体长臂大部分片段丢失,断裂位点位于q11近着丝粒区。该患者核型描述为 45,X,der(Y)t(Y;14)(q11;q11.2),-14 .ish (SRY+, CEP Y+, DYZ1-)。结论: 该患... | zh-cn |
pair_29658241 | To investigate the nursing care of prostate cancer (PCa) patients againstradioactive proctitisinduced byCyberKnifetreatment. Sixty-eightPCapatients undergoingCyberKnife treatment in the observation group receivedspecialnursing care againstradioactive proctitis. The nursing measures includedthoserelevant toCyberKnife tr... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨射波刀治疗前列腺癌放射性直肠炎的护理及对其效果的影响方法: 选取68例前列腺癌患者作为观察组行特色放射性直肠炎护理、射波刀护理、皮 肤护理,出院指导等各项针对性护理措施,提高射波刀治疗效果,同时以54例前列腺癌患者作为对照组,采用传统护理方法。比较两组患者射波刀治疗过程中放射性 直肠炎的发生率及严重程度。 结果: 观察组患者放射性直肠炎发生率显著低于对照组 (2.9% vs 13.0%, P< 0.05) ; 两组放射性直肠炎严重程度比较,差异无统 计学意义 (P>0.05) 。结论: 放射性直肠炎特色护理措施,可明显降低射波刀治疗过程中放射性直肠炎发生率,提高射波刀治疗前列腺癌的效果,值得在临床上广 泛运用。. | zh-cn |
pair_29658242 | To study the effect of transcutaneous electrical acupoint stimulation (TEAS) in the treatment of asthenozoospermia. We randomly divided 72 asthenozoospermia patients into a 2 Hz TEAS (n = 29), a 100 Hz TEAS (n = 20), and a blank control group (n = 23), those in the former two groups treated by 30 minutes of TEAS at 2 H... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究经皮穴位电刺激(TEAS)对弱精子症患者的治疗效果。方法: 将72例弱精子症患者随机分为:2 Hz TEAS治疗组(29例)、100 Hz TEAS治疗组 (20例)及空白对照组(23例)。TEAS治疗组选取双侧肾俞穴、左侧足三里穴及关元穴4个穴位;TEAS参数:施以连续波,频率2 Hz或100 Hz,每日1次,每次30 min 。空白对照组不采取任何治疗手段,时间均为60 d。通过计算机辅助精子分析(CASA)观察2 Hz及100 Hz TEAS治疗对弱精子症患者的精子活动率、浓度、a级精子百分 率及a+b级精子百分率等指标的影响。 同时采用意向治疗分析(ITT)和符合方案数据分析(PP)对临床疗效进行评判。结果: 与... | zh-cn |
pair_29658243 | Over 80% of the patients with prostate cancer (PCa) develop bone metastasis, which seriously affects the patients' quality of life and remains a major cause of morbidity. Radium-223 (Ra-223), a newly approved agent targeting bone metastasis of PCa, can improve the quality of life and prolong the overall survival of the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 骨是前列腺癌最常见的远处转移部位,超过 80%的前列腺癌患者发生骨转移。晚期骨转移严重影响患者的生存质量,同时也是导致其死亡的重要因素。镭- 223(Ra-223)是最近批准上市用于治疗骨转移性前列腺癌的新药,具有既能改善患者生活质量,又能延长患者总体生存期的优势。本文将对近年来Ra-223治疗前列腺癌 骨转移临床研究进展作一综述。. | zh-cn |
pair_29658244 | Lipoic acid (LA) is widely present in the body as a disulfide compound with an extensive biological activity and a strong antioxidant capacity. LA plays an antioxidant role by removing oxygen free radicals, chelating metal ions, and regenerating other antioxidants in the body. Recent studies have shown the effects of L... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 硫辛酸(LA)享有“万能抗氧化剂”之称,在生物体内广泛存在,是一种具有广泛生物学活性的二硫化合物,具有很强的抗氧化活性。LA可以清除体内氧自 由基、螯合金属离子、再生体内其他抗氧化剂来发挥抗氧化作用。近年来研究发现,将LA应用于男性生殖健康问题的预防或治疗,如特发性弱精子症、糖尿病合并勃 起功能障碍及不育、生殖系统严重感染的治疗,预防化疗药物、电离辐射、环境毒物、睾丸缺血再灌注和剧烈运动等多种原因所致的生殖系统损伤,均取得良好的效 果。本文就LA在男性不育中的研究进展做一综述。. | zh-cn |
pair_29658245 | The majority of men with spinal cord injury (SCI) suffer from different types and degrees of erectile dysfunction (ED). The impact of SCL on erectile function depends on the severity and location of the injury. Some patients can restore the residual sexual potential in the period of SCI recovery. Treatments of ED in me... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 大多数脊髓损伤(SCI)的男性患者存在不同类型及程度的勃起功能障碍(ED),这主要取决于SCI的部位和严重程度。SCI康复期,部分男性患者可恢复残留的性功能。SCI后ED的治疗包括心理治疗、口服PDE5抑制剂、海绵体注射血管活性药物(ICI)、经尿道给药、真空勃起装置(VED)及阴茎缩窄环、阴茎假体植入手术、骶神经调节等,首选口服PDE5抑制剂治疗。高位SCI患者口服PDE5抑制剂,可能获得较好的疗效;而低位的SCI患者,采用ICI或者联合治疗的效果较好。. | zh-cn |
pair_29658246 | To investigate the expression characteristic of the Daxx gene in the mouse testis and its role in spermatogenesis. Real-time PCR, Western blot and immunofluorescence were used in examining the expression characteristics of DAXX in the testis tissue from wild-type, Sertoli cell-specific androgen receptor knockout (SCARK... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究死亡结构域相关蛋白(Daxx)基因在小鼠睾丸精子发生过程中的表达特征,初步探讨其在生精过程中的作用。方法: 通过实时荧光定量PCR(qPCR)、Western印迹及免疫荧光等方法检测Daxx在不同周龄野生型小鼠睾丸组织以及成年睾丸支持细胞雄激素受体特异性敲除(SCARKO)和雄激素受体敲除(ARKO)小鼠睾丸中的表达特征。结果: qPCR、Western印迹和免疫荧光结果表明,Daxx基因在出生4周后小鼠睾丸中高表达,且主要定位于细胞核;与野生型小鼠相比,SCARKO小鼠睾丸中DAXX的表达差异不显著(0.853±0.058 vs 1.000±0.015),但在生精细胞细胞核中呈极性分布;DAXX在ARKO小鼠睾丸表达显... | zh-cn |
pair_29658247 | To screen lentiviral vectors carrying siRNA which can specifically down-regulate the gene expression of the sphingosine-1-phosphate receptor 3 (S1PR3) in the corpus cavernosum smooth muscle (CCSM) cells of rats with spontaneous hypertension (SHT) and investigate the influence of the vectors on the signaling pathways of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 筛选出能够高效特异性沉默自发性高血压大鼠(SHR) 阴茎海绵体平滑肌细胞(CCSMC)内1-磷酸鞘氨醇受体3(S1PR3)基因表达的 siRNA 慢病毒载体,并观察其对SHR CCSMC ROCK1、ROCK2、eNOS表达的影响。方法: 以大鼠S1PR3基因 mRNA序列作为干扰靶点,设计并合成3对靶向S1PR3的siRNA序列(siRNA1、siRNA2、siRNA3)及1对阴性对照序列,构建并包装成慢病毒载体。体外培养SHR CCSMC及魏-凯二氏大鼠(WKY)CCSMC,随机分为A组(SHR对照组)、B组(携带阴性对照病毒的SHR CCSMC转染组) 、 C~E组(分别携带靶向S1PR3基因 siRNA 1~3号靶点... | zh-cn |
pair_29658248 | To study the expression of long noncoding RNA (lncRNA) H19 in human prostate cancer tissue and its effect on the glycometabolism and growth of human prostate cancer cells. Realtime quantitative RTPCR (qRTPCR) was employed to detect the expression of lncRNA H19 in human prostate tissues from 20 patients with prostat... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨长链非编码RNA H19在前列腺癌组织中的表达及其对前列腺癌细胞DU145和PC-3糖代谢和生长的影响。方法: 采用实时荧光定量PCR(qPCR)检测20例前列腺癌组织(高分化和低分化各10例)和5例良性前例腺增生组织中H19的表达水平。H19小干扰RNA(siRNA)转染前例腺癌细胞DU145和PC-3,以不转染载体和转染阴性载体作为空白对照组和阴性对照组,MTT法检测转染后DU145和PC-3细胞的生长情况,qPCR检测转染细胞中H19的表达水平,通过测定培养液中葡萄糖和乳酸的含量分析前例腺癌细胞糖代谢的变化。结果: 高分化和低分化前例腺癌组织中H19的相对表达量(0.725±0.385、2.086±0.542)均显... | zh-cn |
pair_29658249 | To explore the longterm influence of vasectomy on the levels of serum androgens in aging males. Using stratified random sampling, we conducted a questionnaire survey and physical examinations among 437 adult males aged ≥40 years, 232 with and 205 without the history of vasectomy. In addition, we measured the levels of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨输精管结扎术对男性中老年期血清雄激素水平的远期影响。 方法: 采用分层整群抽样的方法,抽取遵义地区40岁及以上成年男性437例(有输精管结扎史232例,无结扎史205例)进行问卷调查、体格检查,并检测其血清总睾酮(TT)、性激素结合球蛋白(SHBG)和黄体生成素(LH),计算游离睾酮(cFT)、睾酮分泌指数(TSI)、游离睾酮指数(FTI)。结果: 结扎组TT(17.39±6.57) nmol/L、SHBG(70.28±40.90) nmol/L和LH(10.85±11.73) IU/L均显著高于非结扎组的(16.01±5.41) nmol/L、(58.91±36.89) nmol/L和(8.86±6.49) IU/L,... | zh-cn |
pair_29658250 | To investigate the dynamic changes of serum reproductive hormone levels in old and middleaged males in health examination and their correlation with age and lipid profile. This study included 4 333 men in health examination from January 2011 to December 2014. The men were aged from 40 to 85 years old and divided into ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 调查中老年男性体检人群生殖激素水平的动态变化及与年龄、血脂的关系。方法: 2011年1月至2014年12月40岁以上正常健康体检男性4 333例,年龄40~85岁,70岁以下者按5年间隔分组,70岁以上者为1组,共分为7组。测定血清睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、孕酮(P)、催乳素(PRL)和总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC),并计算睾酮分泌指数(TSI=T/LH)。 结果: 7个年龄组的LH、FSH、E2和TSI水平有显著性差异(P均< 0.05)。≥70岁组的LH、FSH和E2水平显著高于其他6个年龄组(P均< 0.... | zh-cn |
pair_29658251 | To investigate the correlation of the single nucleotide polymorphism (SNP) rs4880 of the superoxide dismutase 2 (SOD2) gene with the risk of male infertility. This casecontrol study included 519 male patients with idiopathic infertility (aged 19-40 [28.93±4.93] years) in the case group and 338 fertile men (aged 19-40 ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨超氧化物歧化酶2(SOD2)基因rs4880位点单核苷酸多态性与男性不育发病风险的相关性。 方法: 采用病例对照研究的方法,选取519例特发性男性不育患者作为病例组,年龄19~40(28.92 ± 4.37)岁,并按精子浓度和前向运动(PR)精子百分率分为无精子症组(n=143)、严重少精子症组(n=175)、少精子症组(n=89)和弱精子症组(n=112)4个亚组;以338例正常生育的男性作为对照组,年龄19~40(28.40 ± 4.25)岁,进行临床数据的采集。用Sequenom MassArray技术对SOD2 rs4880位点进行基因分型,用Logistic回归模型分析SOD2 rs4880位点不同基因型与男... | zh-cn |
pair_29658252 | To investigate the correlation of the single nucleotide polymorphism (SNP) rs1042522 of the tumor protein p53 (TP53) gene with the risk of male infertility. This casecontrol study included 380 male patients with idiopathic infertility and 398 normal fertile men as controls from the Nanjing area. We genotyped the SNP r... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨肿瘤蛋白p53(TP53)基因rs1042522位点单核苷酸多态性与男性不育的关系。方法: 采用病例对照研究,收集南京地区特发性男性不育患者380例(病例组),有生育史的健康男性398例(对照组);并将病例组分为无精子症组(n=140)和少精子症组(n=240)。用Sequence MassArray技术检测TP53基因rs1042522位点的基因型,通过Logistic回归分析该位点多态性与男性不育的相关性。 结果: 病例组与对照组前向运动精子百分率[(10.38 ± 5.57)% vs (42.55 ± 9.57)%]、精子浓度[(13.13 ± 24.96)×10⁶/mlvs (77.34 ± 49.24)×10... | zh-cn |
pair_29658253 | To investigate the effect of surgery on advanced penile cancer without distant metastasis and the factors influencing the prognosis. Between September 2007 and July 2015, we treated 8 cases of advanced penile cancer without distant metastasis by penectomy and lymph node dissection. The patients were aged 37-67 (mean 51... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨无远处转移的晚期阴茎癌的手术疗效及影响预后的因素。方法: 分析2007年9月至2015年7月行阴茎切除术及淋巴结清扫术的无远处转移晚期阴茎癌8例患者的临床资料,患者年龄37~67岁,平均51.1岁,术后随访4~60个月,平均19.25个月,分析影响患者预后的因素及手术疗效。结果: 术后3例存活至今,另5例死亡,死亡率62.5%,从手术到死亡时间4~13个月,平均9个月。术后无明显并发症,4例大面积缺损患者术后皮瓣均预后良好。结论: 无远处转移的晚期阴茎癌患者预后不佳,淋巴结转移是影响预后的重要因素,手术是一种相对有效的治疗手段,皮瓣可以修复肿瘤切除后的大面积皮肤缺损,尚无足够资料证明综合疗法是否有效。. | zh-cn |
pair_29658254 | To investigate the clinical significance of sperm acrosin activity detection in selecting the method of assisted reproduction for patients with unexplained infertility (UI). This retrospective study included 49 UI couples treated by IVFET (49 cycles) after three failures in intrauterine insemination (IUI) and another ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨精子顶体酶检测对不明原因不孕(UI)夫妇选择助孕治疗方案的临床意义。 方法: 回顾性分析2013年1月至2015年12月诊断为UI,并经3次宫腔内人工授精(IUI)治疗失败改行体外受精胚胎移植(IVFET)助孕的49对夫妇共49个周期的临床资料,并对比分析同期因输卵管阻塞因素行常规IVF治疗的95对夫妇的131个周期的临床资料,比较两组实验室数据、临床结局和顶体酶活性差异;进一步根据UI夫妇男方精子顶体酶活性将UI组分成2个亚组:< 36 IU/106精子组共20个周期,≥36 IU/106精子组共29个周期,比较两亚组之间受精率的差异。 结果: ①行IVFET治疗的UI夫妇,比同期因输卵管阻塞行常规IVF的夫妇受... | zh-cn |
pair_29658255 | To study the effects of muskolibanum combination on the proliferation and differentiation of prostate stem cells. We cultured prostate epithelial cells and urogenital sinus mesenchymal (UGSM) cells from 7-10 d old C57BL/6 mice and 16-18 d old pregnant C57BL/6 mice, transplanted the mixed suspension of the two types of... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 研究麝香、乳香配伍处理对前列腺干细胞增殖分化的影响。方法: 选用7~10天龄的C57BL/6雄性幼鼠和16~18天龄的孕鼠,分别分离培养出前列腺上皮细胞和泌尿生殖窦间质(UGSM)细胞,并将二者混悬液移植到SCIDCB.17雄性小鼠的肾包膜下,30 d后收获移植物。将SCIDCB.17小鼠随机分为4组:麝香组、乳香组、麝香+乳香组、空白对照组,每组8只,按组别分别予麝香、乳香、麝香+乳香、生理盐水连续灌胃14 d后,取肾脏组织。通过HE染色形态学观察麝香配伍乳香对前列腺干细胞移植后腺管分化形成、各亚群干细胞分化状态影响,免疫组化和Western印迹检测前列腺干细胞抗原标志物P63、CD133、CD117、sca1的表达分布... | zh-cn |
pair_29658256 | To study the safety and efficacy of Bushen Daozhuo Granules (BDG) in the treatment of type Ⅲ prostatitis. This multicenter randomized controlled clinical trial included 478 patients with type Ⅲ prostatitis, 290 in the trial group and 188 as controls, the former treated with BDG at 200 ml bid and the latter with tamsul... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 探讨补肾导浊颗粒治疗Ⅲ型前列腺炎的安全性和有效性。 方法: 采用多中心随机对照研究,对照组口服盐酸坦索罗辛缓释胶囊,0.2 mg/次,每天1次;治疗组口服补肾导浊颗粒,每次200 ml,每日2次,两组的治疗期为4周。分别于治疗前、治疗4周、停药4周行慢性前列腺炎症状评分(CPSI),评估两组的安全性和有效性。 结果: 共有478例患者完成本研究,其中对照组188例,治疗组290例。对照组在治疗4周后的CPSI为(15.67±3.65)分,显著低于治疗前(21.42±4.02)分(P < 0.05),停药4周后CPSI为(19.03±3.86)分,与治疗前相比较,无显著差异(P >0.05)。治疗组在治疗4周、停药4周的CPS... | zh-cn |
pair_29658257 | To investigate the effects of Ningmitai Capsules (NMT) combined with doxycycline hydrochloride (DH) on chronic prostatitis induced by Ureaplasma urealyticum (Uu). This randomized controlled trial included 240 male patients with Uupositive chronic prostatitis, treated orally with NMT at 4 capsules tid (n= 35), DH at 10... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 观察宁泌泰胶囊联合盐酸多西环素片对溶脲脲原体(Uu)引起的慢性前列腺炎的疗效。方法: 采用随机对照研究方法,选取Uu阳性的慢性前列腺炎患者240例,随机分为中药组(35例)、西药组(78例)和联合组(127例),连续用药2周,观察临床疗效。中药组口服宁泌泰胶囊,4粒/次,3次/日;西药组口服盐酸多西环素片,100 mg/次,2次/日;联合组口服宁泌泰胶囊,4粒/次,3次/日,并联用盐酸多西环素片,100 mg/次,2次/日。结果: 中药组、西药组和联合组Uu转阴率分别为54.3%(19/35),71.8%(56/78)和89.0%(113/127),联合组明显高于中、西药组(P均< 0.05)。联合组、西药组和中药组的治愈率... | zh-cn |
pair_29658258 | To investigate the clinical effects of traditional Chinese medicine (TCM) fumigation on type ⅢA prostatitis with the symptoms of damp heat and blood stasis. We randomly divided 72 cases of type ⅢA prostatitis with the symptoms of damp heat and blood stasis into an experimental and a control group of equal number, the f... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的: 观察中药熏蒸联合盐酸左氧氟沙星治疗ⅢA型前列腺炎(湿热瘀滞证)的临床疗效。方法: 将72例ⅢA型前列腺炎(湿热瘀滞证)患者随机分成两组,其中治疗组36例,对照组36例。治疗组采取中药熏蒸联合盐酸左氧氟沙星胶囊口服治疗,对照组单纯使用盐酸左氧氟沙星胶囊口服治疗。治疗4周后,对比两组疗效及治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIHCPSI)、中医症状评分、最大尿流率(Qmax)、平均尿流率(Qave)的变化情况。结果: 治疗组总有效率(91.7%)显著高于对照组(61.1%),差异有统计学意义(P< 0.01)。总NIHCPSI:治疗组治疗后为(14.5±8.2)分,显著低于治疗前的(26.5±9.3)分和对照组... | zh-cn |
pair_29658259 | Glycogen synthase kinase3 (GSK3α and GSK3β) are serine/threonine protein kinases acting on numerous substrates and involved in the regulation of various cellular functions such as their proliferation, survival, glycogen metabolism, and autophagy. Accumulating evidence indicates that the expression of GSK3α is incre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 糖原合成酶激酶3 (GSK3α和GSK3β)是一种高度保守的丝氨酸/苏氨酸蛋白激酶,它能作用于多种底物,参与细胞增殖与存活、糖原代谢和自噬等调控。免疫组化研究发现GSK3的两个亚型中, GSK3α主要在雄激素依赖性前列腺癌表达增强,而GSK3β则在雄激素非依赖前列腺癌中表达升高,且GSK3β参与雄激素受体的转录活性调控和体内前列腺癌的生长。动物实验研究证实氯化锂等GSK3特异性抑制剂对前列腺癌异植瘤生长具有显著抑制作用。GSK3抑制剂有可能作为晚期前列腺癌的辅助治疗药物。. | zh-cn |
pair_29663337 | This study examined the role of parenthood and parental influences on substance use patterns for 710 stimulant users age 18-61 living in the rural Midwest and Mid-south U.S. Longitudinal growth analyses showed that a maternal history of drug use was associated with increased baseline drug use severity, lesser declines ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 该研究考察了父母角色和家长影响在710位年龄在18到61岁之间生活在美国中西和中南部兴奋剂使用者药物使用模式。纵向成长分析显示母亲药物使用史和药物使用严重度基线增长,严重度较少的降低,以及随时间推移药物使用严重度较大稳定期相关联。家长冲突和药物使用严重度较少降低相关联。药物使用严重度在身为父母的参与者中明显降低。父母双方均有酒精使用史的参与者酒精使用严重度基线较高。而父亲药物使用史和酒精使用严重度较低基线相关联。这些发现表明确认家长影响对于评估成年人药物使用的重要性,并指出要将家长包括在预防和治疗药物使用紊乱的努力中。. | zh-cn |
pair_29663337 | This study examined the role of parenthood and parental influences on substance use patterns for 710 stimulant users age 18-61 living in the rural Midwest and Mid-south U.S. Longitudinal growth analyses showed that a maternal history of drug use was associated with increased baseline drug use severity, lesser declines ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Este estudio analizó el papel que desempeñan la paternidad y las influencias de los padres en los patrones de consumo de sustancias de 710 consumidores de estimulantes de entre 18 y 61 años que viven en el Medio Oeste y Centro-Sur rural de Estados Unidos. Los análisis longitudinales de crecimiento demostraron que los a... | es |
pair_29663349 | Although self-concept has been identified as salient to the psychosocial adjustment of adolescents dealing with a chronic illness (CI), little research has focused on its predictors it. Given that depression and parent-child attachment have been linked to self-concept in the population at large, the goal of this study ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 虽然自我概念已被确认为青少年应对慢性疾病心理社会调试的一个突出因素,然而很少有研究着重预测自我概念。鉴于抑郁和家长-儿童依恋在人群中和自我概念相关,该研究的目的即在一个有慢性病青少年样本中纵向评估这些关系。我们使用从”掌握每个新方向” (MEND)项目(一个为期三个月的针对有慢性病青少年的以家庭为基础的心理社会)中得来的参与者数据和多层面模型来测试自我概念在由50位参与MEND项目青少年(M<sub>age</sub> = 14.56, SD<sub>age</sub> = 1.82)由抑郁症状 和家长-儿童依恋预测的纵向改变。”在项目中度过的时间”和抑郁症状减少都和自我概念随时间推移的增长相关。和母亲与父亲回避依恋的较高基线水... | zh-cn |
pair_29663349 | Although self-concept has been identified as salient to the psychosocial adjustment of adolescents dealing with a chronic illness (CI), little research has focused on its predictors it. Given that depression and parent-child attachment have been linked to self-concept in the population at large, the goal of this study ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Aunque el autoconcepto se cosidera muy importante para la adaptación psicosocial de los adolescentes que sufren una enfermedad crónica (EC), pocas investigaciones se han centrado en qué lo predice. Teniendo en cuenta que la depresión y el apego entre padres e hijos se ha asociado con el autoncepto en la población en ge... | es |
pair_30623981 | Global demand for elephant ivory is contributing to illegal poaching and significant decline of African elephant (Loxondonta africana) populations. To help mitigate decline, countries with legal domestic ivory markets were recommended by the Convention on International Trade in Endangered Species of Wild Fauna and Flor... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 全球范围内对象牙的需求导致了对非洲象 (Loxondonta africana) 的非法偷猎及其种群数量的显著下降。为减缓这一趋势, 《濒危野生动植物种国际贸易公约 (CITES) 》建议允许在国内合法交易象牙的国家关闭国内的象牙商业贸易市场。然而, 对野生动植物贸易执行了更严格的法规也并不一定意味着法规会得到遵守。我们通过在线问卷调查, 分析了英国一百一十五名象牙贸易商自我报告的对象牙贸易法规的遵守情况与被认为会影响对保护法规遵守情况的四个维度 (控制、威慑、合法性和社会规范) 之间的关系。研究发现, 虽然大多数贸易商都声称支持这些法规, 但许多人在交易含有象牙的商品时, 并不总是检查自己是否遵守了这些法规。影响象牙贸易法规遵守情... | zh-cn |
pair_30623981 | Global demand for elephant ivory is contributing to illegal poaching and significant decline of African elephant (Loxondonta africana) populations. To help mitigate decline, countries with legal domestic ivory markets were recommended by the Convention on International Trade in Endangered Species of Wild Fauna and Flor... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Cumplimiento de las Regulaciones del Mercado de Marfil entre Comerciantes del Reino Unido Resumen La demanda mundial por el marfil de elefante está contribuyendo a la caza ilegal y a la declinación significativa de la población del elefante africano (Loxondonta africana). Para ayudar a mitigar la declinación, la Conven... | es |
pair_30624797 | Science denialism retards evidenced-based policy and practice and should be challenged. It has been a particular concern for mitigating global environmental issues, such as anthropogenic climate change. But allegations of science denialism must also be well founded and evidential or they risk eroding public trust in sc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 否定科学主义阻碍了基于证据的政策和实践, 应受到挑战。它特别关注的一个内容是应对全球环境问题, 如人类导致的气候变化。然而, 对否定科学主义的指控也必须有理有据, 否则会损害公众对科学及科学家的信任。最近, 77 篇由学者、科学家和科学作家发表的文章被认为包含入侵物种否定主义的思想(即拒绝接受关于入侵物种的确凿事实, 特别是其负面影响的全球科学共识)。我们对其中 75 篇文章进行了重新评估, 但没有发现其中存在反对科学事实的例子, 只有 5 篇文章可能符合否定科学主义五项特征中的一项。因此, 我们认为对入侵物种否定主义的指控存在不妥之处。出现这些对否定主义的谴责, 可能是因为入侵生物学对其研究对象--入侵物种的定义基于许多主观、规范... | zh-cn |
pair_30624797 | Science denialism retards evidenced-based policy and practice and should be challenged. It has been a particular concern for mitigating global environmental issues, such as anthropogenic climate change. But allegations of science denialism must also be well founded and evidential or they risk eroding public trust in sc... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Sobre Argumentos de la Negación de Especies Invasoras Resumen La negación de la ciencia retrasa las prácticas y políticas basadas en evidencias, por lo que debería ser cuestionada. Esta negación ha sido una preocupación particular para la mitigación de los temas ambientales a nivel mundial, como el cambio climático ant... | es |
pair_30630260 | In the 19th century, modern stomatology education were introduced into China with the impact of the west medicine and education. The apprenticeship of modern stomatology education were carried out by missionaries firstly, and then changed to dental schools established by the missionaries or foreigners, which was replac... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 19世纪,随着近代西方医学及教育的传入,近代口腔医学及口腔医学教育也传入我国。从早期的以传教士师授徒式的口腔医学教育模式,到20世纪初传教士及外籍人士创办牙医教育学校,以及中国牙科医生主持的师授徒、办学等形式的教育,完成了中国近代口腔医学教育的初步实践和积累。. | zh-cn |
pair_30630261 | In recent years, robot-assisted surgery (RAS) has developed rapidly and become one of the hot topics in clinical research. Compared with traditional surgery, RAS has advantages in terms of minimal invasiveness, aesthetics, and functional preservation, and has been gradually applied in clinical practice such as neurosur... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年,机器人辅助手术(robot-assisted surgery,RAS)发展迅速,已成为外科学领域的研究热点之一。与传统手术相比,RAS在微创、美观和功能保存等方面具有明显优势,已逐步应用于神经外科、泌尿外科和头颈外科等领域的临床治疗。在头颈肿瘤的治疗中,RAS可有效降低手术损伤,加快患者术后恢复。本文就RAS在头颈肿瘤原发病灶的切除、颈淋巴结清扫术以及组织缺损修复重建三方面的应用作一综述。. | zh-cn |
pair_30630262 | No matter what kind of therapies you choose, clear aligner treatment (CAT) or fixed orthodontic treatment (FOT), the therapy must be performed on the basis of periodontal health and follow the rule that the treatment cannot be harmful to the periodontal tissues. Doctors and patients prefer the clear aligner treatment b... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 无论是采用无托槽隐形矫治还是固定托槽矫治进行正畸治疗,都必须在牙周健康的基础上进行,且以不损害牙周组织健康为原则。无托槽隐形矫治器因其美观、可摘戴、易清洁的特点深受医师和患者欢迎。有关无托槽隐形矫治对牙周组织健康影响的研究较多,大部分研究得出的结论较一致:与固定矫治相比,无托槽隐形矫治更有利于患者的牙周健康维护。但仍有部分不同观点认为只要进行充分的菌斑控制,矫治器的种类对牙周健康的影响不大。目前牙周炎患者的隐形矫治相关研究较缺乏,尤其是有关重度牙周炎患者的隐形矫治,现阶段研究多为病例对照研究,各项研究观点并不一致。本文主要综述无托槽隐形矫治对牙周健康及牙周炎患者牙周状态的影响,为伴错■畸形的牙周炎患者正畸治疗时矫治器的选择提供参考。... | zh-cn |
pair_30630263 | With the progress of technology, three-dimensional (3D) printing technology has become more and more widely used in stomatology. 3D printed template has played an irreplaceable role in oral implantation; at the same time, 3D printed template, which has been successfully applied to the calcified root canal negotiation, ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 随着科技的进步,三维打印技术在口腔医学中的应用越来越广泛。三维打印导板已在口腔种植中发挥着不可替代的作用;同时,三维打印导板也为牙体牙髓疾病的诊疗提供了新的理念和治疗模式,已成功应用于钙化根管疏通、牙内陷的根管治疗、根尖外科及自体牙移植等。本文从牙体牙髓病的治疗角度,综述三维打印导板在牙体牙髓专业领域中的研究和应用。. | zh-cn |
pair_30637093 | The societal burden of psychiatric disorders that result after exposure to psychological trauma is enormous. The study of trauma-related disorders using neurobiological and public health approaches is often disjointed. It is critical to emphasize the translational potential of neurobiological work and its relevance to ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 暴露于心理创伤后导致的精神疾病带来巨大的社会负担。使用神经生物学和公共卫生方法对创伤相关疾病的研究通常是脱节的。强调神经生物学工作的转化潜力及其与心理创伤的公共卫生负担的相关性至关重要。使用公共卫生模型应用于包括初级、二级和三级水平的创伤学,我们强调了推进神经生物学领域可以为扩展干预措施铺平道路,这些干预措施可以改善结果并帮助解决公共卫生问题。. | zh-cn |
pair_30637093 | The societal burden of psychiatric disorders that result after exposure to psychological trauma is enormous. The study of trauma-related disorders using neurobiological and public health approaches is often disjointed. It is critical to emphasize the translational potential of neurobiological work and its relevance to ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La carga social de los trastornos psiquiátricos que resultan después de la exposición al trauma psicológico es enorme. El estudio de los trastornos relacionados con el trauma que utilizan enfoques neurobiológicos y de salud pública a menudo es inconexo. Es fundamental enfatizar el potencial de traslación del trabajo ne... | es |
pair_30641669 | Neuro-ophthalmology is an interdisciplinary that covers neurology and ophthalmology. Neuro-ophthalmology involves not only visual afferent system disorders but also visual efferent system disorders. We have recognized that any disturbance in afferent system may result in vision decrease or loss. However, our understand... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 任何兼有神经系统和眼部异常的疾病均属神经眼科研究范畴,神经眼科疾病分为视觉传入系统障碍和视觉传出系统障碍两大类。视觉传入系统障碍主要引起视力下降或丧失,而视觉传出系统障碍引起的神经眼科疾病,由于主要表现为斜视、复视、眼球运动异常以及异常头位等,故常首诊于斜视与小儿眼科,而部分眼科医师仅从眼外肌疾病角度思考问题,易忽略视觉传出系统障碍导致的神经眼科问题,给诊断和治疗带来困扰。因此须从掌握常见视觉传出系统障碍性神经眼科疾病的临床特征和多条颅神经麻痹在颅脑中定位的意义入手,重视眼球震颤和瞳孔检查及其临床意义,关注首诊于眼科的传出系统障碍性神经眼科疾病,才能给予患者准确、及时的诊疗指导和干预,从而提高临床诊疗水平。(中华眼科杂志,<i>20... | zh-cn |
pair_30641676 | Synergistic divergence is a rare condition characterized by complete absence of adduction that is associated with simultaneous abduction of the affected eye on attempted adduction. This causes the affected eye to move further into abduction on gaze to the normal side and results in extreme divergence of both eyes. It i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 协同分开是指患眼不能内转,且企图内转时同时伴有外转,导致双眼水平向非患侧方向注视时,双侧外直肌同时收缩,双眼极度分开的一种罕见眼部疾患表现,临床也称为眼球后退综合征合并协同分开或眼球后退综合征4型、先天性眼外肌纤维化合并协同分开。具有协同分开症状的疾病归类于先天性颅神经支配异常性疾病,部分患者同时合并Horner综合征、视盘发育不良等多种眼部或全身异常。治疗协同分开的常用手术包括患眼外直肌后徙或离断联合内直肌缩短术,上、下斜肌同时减弱术以及患眼外直肌眶巩膜固定联合内直肌缩短术,但手术效果有待于大样本临床研究进行观察总结。本文汇总分析了近年国内外文献中有关协同分开的基本概念、病因、临床表现及治疗等的研究进展,以期为临床研究及治疗提供参... | zh-cn |
pair_30641677 | Macular telangiectasia type 2 (MacTel 2) is an idiopathic entity which is characterized by dilated capillary network near, or around, the fovea of the macula. The spectrums secondary to macular retinal vascular inflammation or obstruction are excluded. It is a binocular disease in general. MacTel 2 is now widely recogn... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 特发性黄斑视网膜血管扩张症是一种特发的、非继发于炎性反应或阻塞等已知原因、以黄斑区毛细血管网异常扩张、周围微动脉和微静脉异常扩张以及神经纤维层萎缩为特征的双眼获得性疾病的总称,目前被广泛认为是一种黄斑区神经退行性疾病。本文针对特发性黄斑视网膜血管扩张症的流行病学特征、临床分型及特征、分期、发病机制以及治疗方法进行总结和分析,以期为临床深入研究和探讨提供参考。(中华眼科杂志,<i>2019</i>,<i>55</i>:<i>68</i>-<i>73</i>). | zh-cn |
pair_30643043 | To explore the differential expression of serum miRNAs in patients of advanced non- small cell lung cancer (NSCLC) treated by gifitinib before and after acquiring drug resistance.
Methods: A total of 4 patients with advanced NSCLC from Affiliated Hospital of Yueyang Vocational Technical College, who acquired drug resi... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:研究吉非替尼治疗晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)发生继发性耐药前后患者血清microRNA(miRNAs)表达的差异。方法:选择2013年6月至2015年6月岳阳市职业技术学院附属医院收治的4例经吉非替尼常规治疗出现获得性耐药的晚期NSCLC患者作为研究对象。收集研究对象治疗前和出现获得性耐药后的血清样本。采用miRNA芯片技术对血清样本中miRNAs表达谱进行检测,实时RT-PCR对差异性表达显著的miRNAs进行定量验证。针对筛选出的miRNAs构建抑制剂和拟似剂并转染至肺癌细胞中,检测肺癌细胞对敏感性的变化。结果:发生继发性耐药前后患者血清miRNAs表达发生明显改变。... | zh-cn |
pair_30643044 | To analyze the differentially expressed exosomal miRNAs in subchondral osteoblasts in patients with osteoarthritis (OA) and to investigate the key miRNAs potentially involved in the occurrence and progression of OA.
Methods: Subchondral bones were harvested from 6 patients with OA. All subjects were divided into two g... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:通过分析骨关节炎(osteoarthritis,OA)患者软骨下骨组织中成骨细胞胞外体miRNAs的表达差异,探究OA发生发展过程中可能涉及的关键胞外体miRNAs。方法:共纳入6名膝OA患者,收集其膝关节软骨下骨组织,选取磨损严重侧为OA组,取磨损较少侧为正常对照组。细胞培养后提取成骨细胞胞外体,进行特征鉴定。提取胞外体miRNAs,用高通量测序并筛选两组间表达差异显著者(log2Ratio≥2)进行靶基因预测分析,并进一步行定量反转录PCR分析。结果:提取物经鉴定为胞外体,在扫描电镜下呈囊泡状双层膜结构,直径30~200 nm,体积峰度50~150 nm。高通量测序共筛出5个OA组表达显著上调的miRNAs,差异倍数最大者... | zh-cn |
pair_30643047 | To explore the feasibility and efficacy of artificial neural network for differentiating high-grade glioma and low-grade glioma using image information.
Methods: A total of 130 glioma patients with confirmed pathological diagnosis were selected retrospectively from 2012 to 2017. Forty one imaging features were extract... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:探讨利用人工神经网络对脑胶质瘤进行分级的可行性和有效性。方法:回顾性纳入2012至2017年经病理证实的130例脑胶质瘤患者,基于磁共振增强T1加权相二维图像提取的共41个影像学特征。建立人工神经网络并进行特征选择以得到最优化的神经网络模型,随机抽取一半病例的影像学特征数据对神经网络进行训练,并用另一半特征数据对训练完成后的神经网络进行胶质瘤分级效果验证。对神经网络重复进行100次训练和验证,将结果进行平均。结果:经过特征选择后的神经网络模型共选取5个特征作为输入特征,神经网络对脑胶质瘤分级的平均准确率为90.32%,平均敏感度为87.86%,平均特异度为92.49%,受试者操作曲线的曲线下面积为0.9486。结论:人工神经网... | zh-cn |
pair_30643048 | To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS).
Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017.
Results: All 46 patients had mucocutaneous melanin pigmentation and mu... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:探讨黑斑息肉综合征(Peutz-Jeghers syndrome,PJS)的临床特点、病理特征、基因检测结果、诊断治疗及预后。方法:对2007—2017年收治的46例PJS患者的临床资料进行回顾性分析。 结果:46例患者均存在口唇黏膜黑斑及消化道多发息肉,黑斑多于5岁以内出现,14例有家族史。临床上表现为黑斑、腹痛、便血、贫血等。病理学检查可表现为错构瘤(20例)、腺瘤(18例)、炎性息肉(14例)及锯齿状息肉(10例)等。11例患者行遗传性结直肠癌易感基因(20个)检测,结果提示5例有丝/苏氨酸蛋白激酶(serine/threonine kinase 11,STK11)基因突变,其中3例STK11基因致病证据明确者均有肠套叠... | zh-cn |
pair_30643051 | To explore the risk factors for and the pathogenic mechanisms of pelvic organ prolapse and urinary incontinence.
Methods: A total of 2 668 females who completed pelvic floor functional detection from July 2014 to October 2015 in the Physical Examination Center of the Third Xiangya Hospital of Central South University.... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:分析女性盆腔脏器脱垂和尿失禁的危险因素并探讨其发病机制。方法:选取2014年7月至2015年10月在中南大学湘雅三医院健康管理中心行盆底功能筛查的女性共2 668人,按照有无尿失禁、盆腔脏器脱垂将其分为尿失禁组、盆腔脏器脱垂组、两者均有组及正常组;比较各组年龄、BMI、绝经率、孕产次、分娩方式、盆腹协调性的差异。结果:4组年龄、BMI差异均有统计学意义(P<0.05);正常组的绝经率、孕产次与其他3组差异均有统计学意义(P<0.05),脏器脱垂组的绝经率、孕产次与两者均有组差异有统计学意义(P<0.05),而尿失禁组的绝经率、孕产次与脏器脱垂组、两者均有组差异无统计学意义(P>0.05);正常组的分娩方式与其他3组差异均有统计... | zh-cn |
pair_30643052 | To develop an intervention protocol for children's unintentional injury risk behaviors, and to evaluate the feasibility of the protocol.
Methods: By theoretically analyzing the influential factors for children's unintentional injury risk behaviors, children's cognitive development characteristics and the social learni... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:构建儿童非故意伤害危险行为干预方案,评价该方案的可行性,减少儿童非故意伤害危险行为及非故意伤害事件。方法:通过理论分析儿童非故意伤害危险行为的影响因素、儿童认知发展特征及社会学习理论,建立以改变非故意伤害归因、危险行为后果负性信息传递为基础的干预方案,采用随机整群抽样抽取一所长沙市市区小学,对抽取的学生进行连续5周,每周1次的社区随机对照试验。通过干预前、干预后3个月及干预后6个月非故意伤害危险行为得分的比较,以及干预前及干预后6个月非故意伤害次数比较评价干预效果。结果:194名儿童完成了随访,其中男童96人(49.5%),女童98人(50.5%),年龄7~8岁;干预组98人,对照组96人。干预后3个月、6个月干预组儿童非故意... | zh-cn |
pair_30643053 | Apolipoprotein A5 (Apo A5) is a novel member in apolipoprotein family, which is proven to be an important regulator in triglyceride metabolism, especially in adjusting the TG content in plasma. Apo A5 gene polymorphisms affect triglyceride metabolism and atherosclerotic cardiovascular diseases. The research focuses on ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 载脂蛋白A5(apolipoprotein A5,Apo A5)是载脂蛋白家族成员之一。它是三酰甘油代谢的重要调控因子,调控血浆中三酰甘油含量。Apo A5的基因多态性影响人体三酰甘油代谢,与动脉粥样硬化性心血管疾病密切相关,其中对–1131T>C,c.56C>G,c.553G>T研究最多。. | zh-cn |
pair_30643054 | Sepsis-induced cardiac dysfunction is a serious complication of sepsis with no effective treatment. AMP-activated protein kinase (AMPK) is a regulator for energy metabolism in cells and plays a key role in the energy balance. Recent studies have shown that AMPK exerted a protective effect on sepsis-induced cardiac dysf... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 脓毒症心功能不全是脓毒症的严重并发症,但是目前缺乏有效的治疗方法。腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是细胞的能量代谢调节器,在能量平衡中起关键作用。AMPK对脓毒症心功能不全起保护作用,其机制与调控炎症、内皮细胞损伤、能量代谢、心肌细胞凋亡及自噬相关。因此,AMPK是脓毒症心功能不全的治疗靶点。. | zh-cn |
pair_30643055 | Systemic sclerosis (SSc) is an autoimmune disease with unknown etiology, characterized by vasculopathy, inflammation, and extensive fibrosis in the skin and organs. Fibrosis is the hallmark of SSc and contributes to its high mortality. In recent years, with the in-depth study of the epigenetics of SSc (DNA methylation,... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 系统性硬化症(systemic sclerosis,SSc)是一类病因不明的自身免疫性疾病,以血管病变、炎症和皮肤及各器官广泛纤维化为主要特征。纤维化是SSc的标志,也是导致其高病死率的主要原因。近年来,SSc的表观遗传学(DNA甲基化、组蛋白修饰和非编码RNA)得到了深入的研究,其中以DNA甲基化和微小RNA(microRNA,miRNA)的研究最为广泛。DNA甲基化异常可影响SSc的血管内皮细胞、CD4+T细胞和成纤维细胞的功能。血清中的miRNAs与自身抗体、SSc疾病活动度和并发症密切相关,成纤维细胞中的miRNAs可直接影响成纤维细胞的活化。. | zh-cn |
pair_30643056 | Platinum drugs are widely used in the treatment of various solid tumors, but their resistance to platinum is the most significant obstacle to successful treatment. Copper transporter 1 (CTR1) is the specific transporter for copper, and it mainly locates at the plasma membrane and plays a role in pumping copper into the... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 铂类药物广泛应用于多种实体瘤的治疗,耐药是导致治疗失败最主要的因素之一。铜离子转运体(copper transporter 1,CTR1)是铜离子的特异性转运体,主要位于细胞膜,负责将铜离子泵入细胞。CTR1也是铂类药物的主要转运体,在铂类药物耐药的发生中起重要的作用。CTR1的表达量、基因多态性及降解均会影响铂类药物耐药,因此其可能成为预测铂类药物耐药的生物标志分子和克服铂类药物耐药的新靶标。. | zh-cn |
pair_30643057 | Photodynamic therapy is mainly used in dermatology to treat skin tumors, precancerous lesions, and condyloma acuminatum. Due to its excellent tissue selectivity, easy operation and good cosmetic effect, it has been gradually applied to the treatment of various non-neoplastic skin diseases, such as verruca acuminata, ac... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 光动力疗法在皮肤科主要用于治疗皮肤肿瘤、癌前病变及尖锐湿疣。由于其具有良好的组织选择性和美容效果,且操作简单方便,现在已经逐渐应用于多种非肿瘤性皮肤病的治疗,包括尖锐湿疣、痤疮、玫瑰痤疮、慢性皮肤溃疡、真菌性皮肤病、瘢痕疙瘩等,并取得了良好的治疗效果。. | zh-cn |
pair_30643058 | To investigate the clinical manifestations, imaging features, and diagnosis for non-Hodgkin's lymphoma in the jaw, we retrospectively analyzed 3 cases of non-Hodgkin's lymphoma in the jaw and reviewed relevant literature. Three patients' lesion occurred in the maxilla with early painless masses. Two patients were diagn... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 回顾性分析3例颌骨非霍奇金淋巴瘤患者的临床资料,并复习相关文献。探讨发生于颌骨的非霍奇金淋巴瘤的临床表现、影像学特点及诊断方法。3例均发生于上颌骨,早期为无痛性包块,CT表现为溶骨性病变。2例行活体标本检查示弥漫大B细胞淋巴瘤,1例行上颌骨扩大切除术后病理检查结果示浆母细胞瘤。颌骨非霍奇金淋巴瘤临床及影像学表现无特异性,早期行病变区组织活体标本检查术并病理检查可辅助诊断。. | zh-cn |
pair_30643062 | To investigate the effect of ursolic acid on the invasion and migration of hepatocellular carcinoma (HCC) cells co-cultured with macrophages, and to explore the underlying mechanisms.
Methods: The migration and invasion ability of HCC cells in the co-culture system with or without ursolic acid intervention were evalua... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:研究熊果酸对巨噬细胞-肝癌细胞共培养体中肝癌细胞迁移和侵袭能力的影响,并初步探讨其作用机制。方法:采用Transwell迁移和侵袭试验检测熊果酸处理与非处理的巨噬细胞-肝癌细胞共培养体中肝癌细胞的迁移和侵袭能力的变化;Western印迹法检测共培养体中肝癌细胞上皮-间质转化蛋白E-cadherin,N-cadherin和vimentin的表达情况。结果:共培养后的肝癌细胞的迁移和侵袭能力显著增强,并发生了上皮-间质样表型转变,上皮-间质转化的标志蛋白E-cadherin的表达下调,而N-cadherin和vimentin的表达均上调;熊果酸处理的巨噬细胞-肝癌细胞共培养体中,肝癌细胞的迁移和侵袭能力降低,E-cadherin表... | zh-cn |
pair_30643064 | To investigate the effect of Brucea javanica oil emulsion on proliferation, migration and autophagy of non-small cell lung cancer A549 cells.
Methods: First, A549 cells were divided into a control group and a low, medium or high dose of Brucea javanica oil emulsion groups (0, 2.5, 5.0 or 10.0 mg/mL); then, the cells w... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:探讨鸦胆子油乳对人非小细胞肺癌A549细胞增殖、迁移和自噬的影响及机制。方法:以A549细胞为研究对象,先采用不同浓度的鸦胆子油乳处理,并将其分为对照组和低、中、高剂量鸦胆子油乳组(0,2.5,5.0,10.0 mg/mL);再采用5.0 mg/mL鸦胆子油乳或3-甲基腺嘌呤(3-methyladenine,3-MA)+5.0 mg/mL鸦胆子油乳处理,并将其分为鸦胆子油乳组和3-MA+鸦胆子油乳组。采用细胞计数试剂盒(cell counting kit-8,CCK-8)和克隆形成实验检测细胞增殖,划痕实验和Transwell实验测量细胞迁移;应用细胞免疫荧光和Western印迹分析细胞自噬。结果:与对照组(0 mg/mL)相... | zh-cn |
pair_30643067 | To investigate the feasibility and therapeutic effect of laparoscopy combined with total intersphincteric resection (Total-ISR) for extremely low rectal cancer.
Methods: We performed laparoscopy combined with Total-ISR in 45 patients with extremely low rectal cancer (1.0 cm≤the lower edge of tumor to the anal edge≤3.0... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:探讨腹腔镜联合经肛门完全内括约肌切除术(total intersphincteric resection,Total-ISR)治疗极低位直肠癌的可行性及疗效。方法:对2014年1月至2016年12月45例极低位直肠癌患者(1.0 cm≤肿瘤下缘距肛缘≤3.0 cm)实行腹腔镜联合Total-ISR。观察手术时间、出血量、手术切缘及术后并发症总体发生率;中位随访时间为20.5个月,观察术后局部复发及远处转移情况;比较术后3,6,12个月的肛门功能情况。结果:45名患者均顺利完成手术,无围手术期死亡病例。手术时间(220±33) min。出血量(110±31) mL。手术切缘均阴性。术后并发症的总体发生率为6.7%(3/45),无... | zh-cn |
pair_30643068 | To observe the clinical efficacy of dopamine modulator methylphenidate (MPH) of extended-release formulations (MPH-ER) augmentation of ongoing fluvoxamine treatment in refractory obsessive-compulsive disorder (OCD) and its effects on patient's anxiety and sleep quality.
Methods: A pilot randomized, placebo-controlled,... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:观察氟伏沙明联合长效哌甲酯治疗难治性强迫症的临床效果,探讨该治疗对患者焦虑情绪和睡眠质量的影响。方法:采取随机、双盲、安慰剂对照研究,将44例强迫症患者随机分成两组,每组22例,研究组服用氟伏沙明和长效哌甲酯缓释片,对照组服用氟伏沙明和安慰剂,随访时间均为8周。采用耶鲁-布朗强迫症状量表(Yale-Brown Obsessive Compulsive Scale,Y-BOCS)、汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评定临床疗效,采用匹兹堡睡眠质量指数量表(Pittsburgh Sleep Quality Index,PSQI)评定睡眠质量,采用不良反应量表(Treatment Emerge... | zh-cn |
pair_30643069 | To investigate the efficacy of manipulation combined with electrical stimulation and biofeedback on the treatment of female sexual dysfunction.
Methods: Seventy-two female patients with sexual dysfunction were recruited from the Third Xiangya Hospital of Central South University from January 2014 to December 2015. Su... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:探讨手法联合电刺激和生物反馈治疗女性性功能障碍的疗效。方法:选取2014年1月至2015年12月在中南大学湘雅三医院康复科门诊就诊的72例女性患者,均诊断为产后性功能障碍,按照数字法随机分为A,B,C 3组,每组24名。A组进行手法治疗,B组进行电刺激和生物反馈治疗,C组进行手法联合电刺激和生物反馈治疗。检测3组患者盆底肌肌电位及I,II类肌纤维肌力,并采用问卷调查的方法调查患者治疗前后性生活次数及性高潮次数,比较3组患者治疗前后盆底肌肉功能及性功能客观指标的评分。治疗时间周期为1个月,在治疗结束1个月后进行随访。结果:与A,B两组比较,C组患者盆底电生理指标肌力和肌电位均较高(P<0.05);并且性功能改善情况更优(P<0.... | zh-cn |
pair_30643070 | To observe the results of different treatment of congenital heart disease (CHD) complicated with severe pneumonia in infants.
Methods: A total of 27 infants with CHD and severe pneumonia were admitted to the Department of Pediatrics, Xiangya Hospital from January 2014 to December 2014, of whom 18 were male and 9 were ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的:研究先天性心脏病婴幼儿合并重症肺炎的不同治疗方法及预后,探讨最佳的治疗策略。方法:中南大学湘雅医院儿科2014年1月至12月共收治27例先天性心脏病合并重症肺炎的患儿,其中男18例,女9例;年龄2.0~19.0(5.9±4.3)个月,体重3.3~10.0(5.8±1.8) kg;均采用完全控制肺部感染后再考虑手术治疗的策略(内科治疗组)。2015年1月至12月共收治29例先天性心脏病合并重症肺炎的患儿,其中男15例,女14例;年龄2.0~27.0(6.1±3.9)个月,体重3.1~8.0(4.8±1.0) kg;积极采用抗生素及对症支持治疗,无明显改善则安排手术治疗(联合治疗组)。结果:内科治疗组患儿住院时间为3~26(11±... | zh-cn |
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