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Diazepam binds with high affinity to glial cells in animal cell cultures. Diazepam at high doses has been found to decrease histamine turnover in mouse brain via diazepam's action at the benzodiazepine-GABA receptor complex. Diazepam also decreases prolactin release in rats.
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Benzodiazepines are positive allosteric modulators of the GABA type A receptors (GABA). The GABA receptors are ligand-gated chloride-selective ion channels that are activated by GABA, the major inhibitory neurotransmitter in the brain. Binding of benzodiazepines to this receptor complex promotes the binding of GABA, wh...
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The GABA receptor is a heteromer composed of five subunits, the most common ones being two αs, two βs, and one γ (α2β2γ). For each subunit, many subtypes exist (α1–6, β1–3, and γ1–3). GABA receptors containing the α1 subunit mediate the sedative, the anterograde amnesic, and partly the anticonvulsive effects of diazepa...
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Diazepam appears to act on areas of the limbic system, thalamus, and hypothalamus, inducing anxiolytic effects. Benzodiazepine drugs including diazepam increase the inhibitory processes in the cerebral cortex.
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The anticonvulsant properties of diazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems limited by benzodiazepines' effect of slowing recovery of sodium channels from inactivation.
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The muscle relaxant properties of diazepam are produced via inhibition of polysynaptic pathways in the spinal cord.
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Diazepam can be administered orally, intravenously (must be diluted, as it is painful and damaging to veins), intramuscularly (IM), or as a suppository.
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The onset of action is one to five minutes for IV administration and 15–30 minutes for IM administration. The duration of diazepam's peak pharmacological effects is 15 minutes to one hour for both routes of administration. The half-life of diazepam in general is 30–56 hours. Peak plasma levels occur between 30 and 90 m...
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Diazepam is highly lipid-soluble, and is widely distributed throughout the body after administration. It easily crosses both the blood–brain barrier and the placenta, and is excreted into breast milk. After absorption, diazepam is redistributed into muscle and adipose tissue. Continual daily doses of diazepam quickly b...
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Diazepam is stored preferentially in some organs, including the heart. Absorption by any administered route and the risk of accumulation is significantly increased in the neonate, and withdrawal of diazepam during pregnancy and breast feeding is clinically justified.
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Diazepam undergoes oxidative metabolism by demethylation (CYP 2C9, 2C19, 2B6, 3A4, and 3A5), hydroxylation (CYP 3A4 and 2C19) and glucuronidation in the liver as part of the cytochrome P450 enzyme system. It has several pharmacologically active metabolites. The main active metabolite of diazepam is desmethyldiazepam (a...
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Diazepam is a 1,4-benzodiazepine. Diazepam occurs as solid white or yellow crystals with a melting point of 131.5 to 134.5 °C. It is odorless, and has a slightly bitter taste. The British Pharmacopoeia lists it as being very slightly soluble in water, soluble in alcohol, and freely soluble in chloroform. The United Sta...
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Diazepam should be stored at room temperature (15–30 °C). The solution for parenteral injection should be protected from light and kept from freezing. The oral forms should be stored in air-tight containers and protected from light.
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Diazepam can absorb into plastics, so liquid preparations should not be kept in plastic bottles or syringes, etc. As such, it can leach into the plastic bags and tubing used for intravenous infusions. Absorption appears to depend on several factors, such as temperature, concentration, flow rates, and tube length. Diaze...
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Diazepam may be quantified in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest, or to assist in a medicolegal death investigation. Blood or plasma diazepam concentrations are usually in a range of 0.1–1.0 mg/L in persons receiving the drug ther...
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Diazepam was the second benzodiazepine invented by Leo Sternbach of Hoffmann-La Roche at the company's Nutley, New Jersey, facility following chlordiazepoxide (Librium), which was approved for use in 1960. Released in 1963 as an improved version of Librium, diazepam became incredibly popular, helping Roche to become a ...
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The benzodiazepines gained popularity among medical professionals as an improvement over barbiturates, which have a comparatively narrow therapeutic index, and are far more sedative at therapeutic doses. The benzodiazepines are also far less dangerous; death rarely results from diazepam overdose, except in cases where ...
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Marketed by Roche using an advertising campaign conceived by the William Douglas McAdams Agency under the leadership of Arthur Sackler, diazepam was the top-selling pharmaceutical in the United States from 1969 to 1982, with peak annual sales in 1978 of 2.3 billion tablets. Diazepam, along with oxazepam, nitrazepam and...
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Diazepam is a medication with a high risk of misuse and can cause drug dependence. Urgent action by national governments has been recommended to improve prescribing patterns of benzodiazepines such as diazepam. A single dose of diazepam modulates the dopamine system in similar ways to how morphine and alcohol modulate ...
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Diazepam has been shown to be able to substitute for the behavioral effects of barbiturates in a primate study.
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Diazepam drug misuse can occur either through recreational misuse where the drug is taken to achieve a high or when the drug is continued long term against medical advice.
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Sometimes, it is used by stimulant users to "come down" and sleep and to help control the urge to binge. These users often escalate dosage from 2 to 25 times the therapeutic dose of 5 to 10 mg.
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A large-scale study in the US, conducted by SAMHSA, using data from 2011, determined benzodiazepines were present in 28.7% of emergency department visits involving nonmedical use of pharmaceuticals. In this regard, benzodiazepines are second only to opiates, the study found in 39.2% of visits. About 29.3% of drug-relat...
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Diazepam was detected in 26% of cases of people suspected of driving under the influence of drugs in Sweden, and its active metabolite nordazepam was detected in 28% of cases. Other benzodiazepines and zolpidem and zopiclone also were found in high numbers. Many drivers had blood levels far exceeding the therapeutic do...
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Classified as a controled drug, listed under Schedule IV, Part I (CD Benz POM) of the Misuse of Drugs Regulations 2001, allowing possession with a valid prescription. The Misuse of Drugs Act 1971 makes it illegal to possess the drug without a prescription, and for such purposes it is classified as a Class C drug.
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Classified as a prescription-drug, or in high dosage as a restricted drug ("Betäubungsmittelgesetz, Anlage III").
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Diazepam is a Schedule-4-substance under the Poisons Standard (June 2018). A schedule-4-drug is outlined in the Poisons Act 1964 as, "Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on presc...
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The states of California and Florida offer diazepam to condemned inmates as a pre-execution sedative as part of their lethal injection program, although the state of California has not executed a prisoner since 2006. In August 2018, Nebraska used diazepam as part of the drug combination used to execute Carey Dean Moore...
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Diazepam is used as a short-term sedative and anxiolytic for cats and dogs, sometimes used as an appetite stimulant. It can also be used to stop seizures in dogs and cats.
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In telecommunications, 5G is the fifth-generation technology standard for broadband cellular networks, which cellular phone companies began deploying worldwide in 2019, and is the planned successor to the 4G networks which provide connectivity to most current cellphones. 5G networks are predicted to have more than 1.7 ...
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Like its predecessors, 5G networks are cellular networks, in which the service area is divided into small geographical areas called "cells". All 5G wireless devices in a cell are connected to the Internet and telephone network by radio waves through a local antenna in the cell. The new networks have higher download spe...
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5G networks are cellular networks, in which the service area is divided into small geographical areas called "cells". All 5G wireless devices in a cell communicate by radio waves with a cellular base station via fixed antennas, over frequency channels assigned by the base station. The base stations, termed nodes, are c...
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The industry consortium setting standards for 5G, the 3rd Generation Partnership Project (3GPP), defines "5G" as any system using 5G NR (5G New Radio) software - a definition that came into general use by late 2018.
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Several network operators use millimeter waves called FR2 in 5G terminology, for additional capacity and higher throughputs. Millimeter waves have a shorter range than the lower frequency microwaves, therefore the cells are of a smaller size. Millimeter waves also have more trouble passing through building walls. Milli...
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The increased data rate is achieved partly by using additional higher-frequency radio waves in addition to the low- and medium-band frequencies used in previous cellular networks. For providing a wide range of services, 5G networks can operate in three frequency bands low, medium, and high.
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5G can be implemented in low-band, mid-band or high-band millimeter-wave 24 GHz up to 54 GHz. Low-band 5G uses a similar frequency range to 4G cellphones, 600–900 MHz, giving download speeds a little higher than 4G: 30–250 megabits per second (Mbit/s). Low-band cell towers have a range and coverage area similar to 4G t...
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Due to their higher cost, plans are to deploy these cells only in dense urban environments and areas where crowds of people congregate such as sports stadiums and convention centers. The above speeds are those achieved in actual tests in 2020, and speeds are expected to increase during rollout.
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Rollout of 5G technology has led to debate over its security and relationship with Chinese vendors. It has also been the subject of health concerns and misinformation, including discredited conspiracy theories linking it to the COVID-19 pandemic.
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The ITU-R has defined three main application areas for the enhanced capabilities of 5G. They are Enhanced Mobile Broadband (eMBB), Ultra Reliable Low Latency Communications (URLLC), and Massive Machine Type Communications (mMTC). Only eMBB is deployed in 2020; URLLC and mMTC are several years away in most locations.
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Enhanced Mobile Broadband (eMBB) uses 5G as a progression from 4G LTE mobile broadband services, with faster connections, higher throughput, and more capacity. This will benefit areas of higher traffic such as stadiums, cities, and concert venues.
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Ultra-Reliable Low-Latency Communications (URLLC) refer to using the network for mission critical applications that require uninterrupted and robust data exchange. The short-packet data transmission is used to meet both reliability and latency requirements of the wireless communication networks.
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Massive Machine-Type Communications (mMTC) would be used to connect to a large number of devices. 5G technology will connect some of the 50 billion connected IoT devices. Most will use the less expensive Wi-Fi. Drones, transmitting via 4G or 5G, will aid in disaster recovery efforts, providing real-time data for emerge...
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5G speeds will range from around 50 Mbps to 1,000 Mbps (1 Gbps) depending on the RF channel and BS load. The fastest 5G speeds would be in the mmWave bands and can reach 4 Gbit/s with carrier aggregation and MIMO (assuming a perfect channel and no other BS load).
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Sub-6 GHz 5G (mid-band), by far the most common, can deliver between 10 and 1,000 Mbps; it will have a much further reach than mmWave bands. In the sub-6 bands, C-Band (n77/n78) will be deployed by various U.S. operators in 2022. C-Band had been planned to be deployed by Verizon and AT&T in early January 2022 but was d...
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Low bands (such as n5) offer a greater range, thereby a greater coverage area for a given site, but their speeds are lower than the mid and high bands.
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In 5G, the ideal "air latency" is of the order of 8–12 milliseconds i.e., excluding delays due to HARQ retransmissions, handovers, etc. Retransmission latency and backhaul latency to the server must be added to the "air latency" for correct comparisons. Verizon reported the latency on its 5G early deployment is 30 ms. ...
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Latency is much higher during handovers; ranging from 50 to 500 milliseconds depending on the type of handover. Reducing handover interruption time is an ongoing area of research and development.
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5G uses adaptive modulation and coding scheme (MCS) to keep the bit error rate (BLER) extremely low. Whenever the error rate crosses a (very low) threshold the transmitter will switch to a lower MCS, which will be less error-prone. This way speed is sacrificed to ensure an almost zero error rate.
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The range of 5G depends on many factors: transmit power, frequency, and interference. For example, mmWave (e.g.:band n258) will have a lower range than mid-band (e.g.: band n78) which will have a lower range than low-band (e.g.: band n5)
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Given the marketing hype on what 5G can offer, simulators and drive tests are used by cellular service providers for the precise measurement of 5G performance.
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Initially, the term was associated with the International Telecommunication Union's IMT-2020 standard, which required a theoretical peak download speed of 20 gigabits per second and 10 gigabits per second upload speed, along with other requirements. Then, the industry standards group 3GPP chose the 5G NR (New Radio) st...
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5G NR can include lower frequencies (FR1), below 6 GHz, and higher frequencies (FR2), above 24 GHz. However, the speed and latency in early FR1 deployments, using 5G NR software on 4G hardware (non-standalone), are only slightly better than new 4G systems, estimated at 15 to 50% better.
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The 5G system architecture is defined in TS 23.501. The packet protocol for mobility management (establishing connection and moving between base stations) and session management (connecting to networks and network slices) is described in TS 24.501. Specifications of key data structures are found in TS 23.003.
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IEEE covers several areas of 5G with a core focus in wireline sections between the Remote Radio Head (RRH) and Base Band Unit (BBU). The 1914.1 standards focus on network architecture and dividing the connection between the RRU and BBU into two key sections. Radio Unit (RU) to the Distributor Unit (DU) being the NGFI-I...
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5G NR (New Radio) is a new air interface developed for the 5G network. It is supposed to be the global standard for the air interface of 3GPP 5G networks.
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In the Internet of things (IoT), 3GPP is going to submit evolution of NB-IoT and eMTC (LTE-M) as 5G technologies for the LPWA (Low Power Wide Area) use case.
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Beyond mobile operator networks, 5G is also expected to be used for private networks with applications in industrial IoT, enterprise networking, and critical communications, in what being described as NR-U (5G NR in Unlicensed Spectrum)
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Initial 5G NR launches depended on pairing with existing LTE (4G) infrastructure in non-standalone (NSA) mode (5G NR radio with 4G core), before maturation of the standalone (SA) mode with the 5G core network.
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As of April 2019, the Global Mobile Suppliers Association had identified 224 operators in 88 countries that have demonstrated, are testing or trialing, or have been licensed to conduct field trials of 5G technologies, are deploying 5G networks or have announced service launches. The equivalent numbers in November 2018 ...
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When South Korea launched its 5G network, all carriers used Samsung, Ericsson, and Nokia base stations and equipment, except for LG U Plus, who also used Huawei equipment. Samsung was the largest supplier for 5G base stations in South Korea at launch, having shipped 53,000 base stations at the time, out of 86,000 base ...
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The first fairly substantial deployments were in April 2019. In South Korea, SK Telecom claimed 38,000 base stations, KT Corporation 30,000 and LG U Plus 18,000; of which 85% are in six major cities. They are using 3.5 GHz (sub-6) spectrum in non-standalone (NSA) mode and tested speeds were from 193 to 430 Mbit/s down....
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Nine companies sell 5G radio hardware and 5G systems for carriers: Altiostar, Cisco Systems, Datang Telecom/Fiberhome, Ericsson, Huawei, Nokia, Qualcomm, Samsung, and ZTE.
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Large quantities of new radio spectrum (5G NR frequency bands) have been allocated to 5G. For example, in July 2016, the U.S. Federal Communications Commission (FCC) freed up vast amounts of bandwidth in underused high-band spectrum for 5G. The Spectrum Frontiers Proposal (SFP) doubled the amount of millimeter-wave unl...
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, there are reportedly 52 countries, territories, special administrative regions, disputed territories and dependencies that are formally considering introducing certain spectrum bands for terrestrial 5G services, are holding consultations regarding suitable spectrum allocations for 5G, have reserved spectrum for 5G, h...
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In March 2019, the Global Mobile Suppliers Association released the industry's first database tracking worldwide 5G device launches. In it, the GSA identified 23 vendors who have confirmed the availability of forthcoming 5G devices with 33 different devices including regional variants. There were seven announced 5G dev...
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In the 5G IoT chipset arena, as of April 2019 there were four commercial 5G modem chipsets and one commercial processor/platform, with more launches expected in the near future.
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On March 6, 2020, the first-ever all-5G smartphone Samsung Galaxy S20 was released. According to "Business Insider", the 5G feature was showcased as more expensive in comparison with 4G; the line up starts at US$1,000, in comparison with Samsung Galaxy S10e which started at US$750. On March 19, HMD Global, the current ...
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Many phone manufacturers support 5G. Apple iPhone 12 and later versions support 5G. Google Pixel phones support it, since version 5.
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The air interface defined by 3GPP for 5G is known as New Radio (NR), and the specification is subdivided into two frequency bands, FR1 (below 6 GHz) and FR2 (24–54 GHz)
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Otherwise known as sub-6, the maximum channel bandwidth defined for FR1 is 100 MHz, due to the scarcity of continuous spectrum in this crowded frequency range. The band most widely being used for 5G in this range is 3.3–4.2 GHz. The Korean carriers use the n78 band at 3.5 GHz.
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Some parties used the term "mid-band" frequency to refer to higher part of this frequency range that was not used in previous generations of mobile communication.
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The minimum channel bandwidth defined for FR2 is 50 MHz and the maximum is 400 MHz, with two-channel aggregation supported in 3GPP Release 15. The higher the frequency, the greater the ability to support high data-transfer speeds. Signals in this frequency range with wavelengths between 4 and 12 mm are called millimete...
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5G in the 24 GHz range or above use higher frequencies than 4G, and as a result, some 5G signals are not capable of traveling large distances (over a few hundred meters), unlike 4G or lower frequency 5G signals (sub 6 GHz). This requires placing 5G base stations every few hundred meters in order to use higher frequency...
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MIMO systems use multiple antennas at the transmitter and receiver ends of a wireless communication system. Multiple antennas use the spatial dimension for multiplexing in addition to the time and frequency ones, without changing the bandwidth requirements of the system.
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Massive MIMO (multiple-input and multiple-output) antennas increases sector throughput and capacity density using large numbers of antennas. This includes Single User MIMO and Multi-user MIMO (MU-MIMO).
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In general, more antennas equal better performance. But more antennas also require bigger arrays that draw more power. Some of the places service providers deploy radio links have very tight constraints, so finding the right solution means weighing tradeoffs. For in-building coverage, the performance gain is often wort...
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Edge computing is delivered by computing servers closer to the ultimate user. It reduces latency, data traffic congestion and can improve service availability.
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Small cells are low-powered cellular radio access nodes that operate in licensed and unlicensed spectrum that have a range of 10 meters to a few kilometers. Small cells are critical to 5G networks, as 5G's radio waves can't travel long distances, because of 5G's higher frequencies.
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One expected benefit of the transition to 5G is the convergence of multiple networking functions to achieve cost, power, and complexity reductions. LTE has targeted convergence with Wi-Fi band/technology via various efforts, such as License Assisted Access (LAA; 5G signal in unlicensed frequency bands that are also use...
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Initially, cellular mobile communications technologies were designed in the context of providing voice services and Internet access. Today a new era of innovative tools and technologies is inclined towards developing a new pool of applications. This pool of applications consists of different domains such as the Interne...
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The channel coding techniques for 5G NR have changed from Turbo codes in 4G to polar codes for the control channels and LDPC (low-density parity check codes) for the data channels.
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In December 2018, 3GPP began working on unlicensed spectrum specifications known as 5G NR-U, targeting 3GPP Release 16. Qualcomm has made a similar proposal for LTE in unlicensed spectrum.
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A report published by the European Commission and European Agency for Cybersecurity details the security issues surrounding 5G. The report warns against using a single supplier for a carrier's 5G infrastructure, especially those based outside the European Union. (Nokia and Ericsson are the only European manufacturers o...
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On October 18, 2018, a team of researchers from ETH Zurich, the University of Lorraine and the University of Dundee released a paper entitled, "A Formal Analysis of 5G Authentication". It alerted that 5G technology could open ground for a new era of security threats. The paper described the technology as "immature and ...
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IoT Analytics estimated an increase in the number of IoT devices, enabled by 5G technology, from 7 billion in 2018 to 21.5 billion by 2025. This can raise the attack surface for these devices to a substantial scale, and the capacity for DDoS attacks, cryptojacking, and other cyberattacks could boost proportionally. In ...
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Due to fears of potential espionage of users of Chinese equipment vendors, several countries (including the United States, Australia and the United Kingdom as of early 2019) have taken actions to restrict or eliminate the use of Chinese equipment in their respective 5G networks. Chinese vendors and the Chinese governme...
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The spectrum used by various 5G proposals, especially the n258 band centered at 26 GHz, will be near that of passive remote sensing such as by weather and Earth observation satellites, particularly for water vapor monitoring at 23.8 GHz. Interference is expected to occur due to such proximity and its effect could be si...
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The concerns prompted U.S. Secretary of Commerce Wilbur Ross and NASA Administrator Jim Bridenstine in February 2019 to urge the FCC to delay some spectrum auction proposals, which was rejected. The chairs of the House Appropriations Committee and House Science Committee wrote separate letters to FCC chairman Ajit Pai ...
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At the 2019 quadrennial World Radiocommunication Conference (WRC), atmospheric scientists advocated for a strong buffer of −55 dBW, European regulators agreed on a recommendation of −42 dBW, and US regulators (the FCC) recommended a restriction of −20 dBW, which would permit signals 150 times stronger than the European...
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The United States FAA has warned that radar altimeters on aircraft, which operate between 4.2 and 4.4 GHz, might be affected by 5G operations between 3.7 and 3.98 GHz. This is particularly an issue with older altimeters using RF filters which lack protection from neighboring bands. This is not as much of an issue in Eu...
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On December 31, 2021, U.S. Transportation Secretary Pete Buttigieg and Steve Dickinson, administrator of the Federal Aviation Administration asked the chief executives of AT&T and Verizon to delay 5G implementation over aviation concerns. The government officials asked for a two-week delay starting on January 5, 2022, ...
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The FAA rushed to test and certify radar altimeters for interference so that planes could be allowed to perform instrument landings (e.g. at night and in low visibility) at affected airports. By January 16, it had certified equipment on 45% of the U.S. fleet, and 78% by January 20. Airlines complained about the avoidab...
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A number of 5G networks deployed on the radio frequency band of 3.3–3.6 GHz is expected to cause interference with C-Band satellite stations, which operate by receiving satellite signals at 3.4–4.2 GHz frequency. This interference can be mitigated with low-noise block downconverters and waveguide filters.
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In regions like the US and EU, the 6 GHz band is to be opened up for unlicensed applications, which would permit the deployment of 5G-NR Unlicensed, 5G version of LTE in unlicensed spectrum, as well as Wi-Fi 6e. However, interference could occur with the co-existence of different standards in the frequency band.
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There have been concerns surrounding the promotion of 5G, questioning whether the technology is overhyped. There are questions on whether 5G will truly change the customer experience, ability for 5G's mmWave signal to provide significant coverage, overstating what 5G can achieve or misattributing continuous technologic...
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There is a long history of fear and anxiety surrounding wireless signals that predates 5G technology. The fears about 5G are similar to those that have persisted throughout the 1990s and 2000s. They center on fringe claims that non-ionizing radiation poses dangers to human health. Unlike ionizing radiation, non-ionizin...
https://en.wikipedia.org/wiki?curid=23475353
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Many popular books of dubious merit have been published on the subject including one by Joseph Mercola alleging that wireless technologies caused numerous conditions from ADHD to heart diseases and brain cancer. Mercola has drawn sharp criticism for his anti-vaccinationism during the COVID-19 pandemic and was warned by...
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According to the "New York Times", one origin of the 5G health controversy was an erroneous unpublished study that physicist Bill P. Curry did for the Broward County School Board in 2000 which indicated that the absorption of external microwaves by brain tissue increased with frequency. According to experts this was wr...
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In April 2019, the city of Brussels in Belgium blocked a 5G trial because of radiation rules. In Geneva, Switzerland, a planned upgrade to 5G was stopped for the same reason. The Swiss Telecommunications Association (ASUT) has said that studies have been unable to show that 5G frequencies have any health impact.
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According to CNET, "Members of Parliament in the Netherlands are also calling on the government to take a closer look at 5G. Several leaders in the United States Congress have written to the Federal Communications Commission expressing concern about potential health risks. In Mill Valley, California, the city council b...
https://en.wikipedia.org/wiki?curid=23475353