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<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : there is evidence corroborating the relationship of vascular dysfunction during the first decade of life with risk factors such as familial hypercho...
### Summary: : objectivemany diseases form their basis during childhood . one example is the changes in vascular structure and function , leading to atherosclerosis . in this study , we have assessed the impact of exposure to cigarette smoke on blood pressure of elementary school children in kermanshah.methods80 el...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the present analysis was performed as part of the diabetes and informatics ( dai ) study , a multicenter cohort study conducted by the dai study gro...
### Summary: : objective the purpose of this study was to assess incidence of and risk factors for recurrent cardiovascular disease ( cvd ) in type 2 diabetes.research design and methods we estimated the incidence of recurrent cardiovascular events in type 2 diabetic patients , aged 4097 years , followed by a netwo...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : electrophysiological brain signals are widely studied to get insights into the inner function of the brain . the electro - encephalogram ( eeg ) ,...
### Summary: : electrophysiological signals such as the eeg , meg , or lfps have been extensively studied over the last decades , and elaborate signal processing algorithms have been developed for their analysis . many of these methods are based on time - frequency decomposition to account for the signals ' spectra...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : written informed consent was obtained from the patient for publication of this case report and accompanying images . a copy of the written c...
### Summary: : lumbar hernias are uncommon and about 300 cases have been reported till date . they commonly occur due to trauma , surgery and infection . they are increasingly being reported after motor vehicle collision injuries . however , spontaneous lumbar hernias are rare and are reported infrequently . it is ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : gastroesophageal reflux disease ( gerd ) is one of the most frequently occurring benign functional disorders in western industrial countries . the...
### Summary: : background and objectives : gastroesophageal reflux disease ( gerd ) is commonly associated with morbid obesity ( mo ) . antireflux surgery has a higher failure rate in mo and addresses only one of the comorbidities present . this paper reviews the results of laparoscopic rouxen - y gastric bypass ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : acute epidural hematoma ( edh ) accounts for 2.7% to 11% of traumatic brain injuries ( tbis ) , and if the size is large , the disease leads to deva...
### Summary: : objectivea small epidural hematoma ( edh ) that has been diagnosed to be nonsurgical by initial brain computed tomography ( ct ) can increase in size and need surgical removal , resulting in a poor prognosis . however , there have been few studies , which focused delayed operated edh . therefore , ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: :
### Summary: : asbestos and silica are well - known fibrogenic dusts . however , there is no comprehensive understanding of the molecular and cellular events that lead to fibrosis as a consequence of asbestos or silica inhalation . previous studies have shown that asbestos stimulates superoxide anion production in ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : duodeno - duodenal intussusception , which involves the distal invagination of a segment of the duodenum , is a rare condition owing to the retroper...
### Summary: : highlightsintussusception is not always seen on ultrasonography but can revealed by a ct-scan.any child , and especially those with previous congenital disorders , must undergo upper gi- endoscopy at the presence of intermittent upper gastrointestinal symptoms as vomiting , abdominal pain and gastro - ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : it is characterized by autoantibodies that target against liver - specific and non - organ - specific antigens ( 1 ) . corticosteroids , especiall...
### Summary: : prednisone or prednisolone are the mainstay drug treatments for autoimmune hepatitis in children . however , long - term use of corticosteroid is associated with the risk of steroid - induced toxicities , and this situation requires newer immuno - suppressive agents for the treatment of autoimmune hepa...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : congenital mitral valve anomalies are very rare clinical entities involving one or more components of the mitral valve apparatus . the majority of...
### Summary: : a 55-year - old male presented with stroke . transesophageal echocardiogram and cardiac computed tomography revealed an unrecognized congenital malformation of the anterior mitral leaflet associated with anomalous left coronary circumflex artery , arising from the right coronary artery , diagnosed fi...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : nontraumatic spontaneous intracranial hemorrhage ( ich ) causes significant morbidity and mortality throughout the world . ten to 20% of strokes a...
### Summary: : objectivespontaneous intracerebral hemorrhage ( ich ) in young adults is rare . the purpose of this study was to investigate causes , sites and other factors affecting the prognosis of ich in young adults aged 40 years.methodswe reviewed 39 consecutive patients diagnosed with spontaneous ich between j...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : given that almost three quarters of older adults lack decision - making capacity when urgent choices about life - sustaining treatment need to be ma...
### Summary: : older adults have long been encouraged to maintain their autonomy by expressing their wishes for health care before they become too ill to meaningfully participate in decision making . this study explored the manner in which community - dwelling adults aged 55 and older plan for serious illness . a...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : lung cancer is the leading cause of cancer death in most countries . although much effort has been made over the last few decades to improve the sur...
### Summary: : the purpose of this prospective study was to determine whether using magnetic resonance imaging ( mri ) for early screening for brain metastases ( bm ) can improve quality of life , survival in patients with non - small cell lung cancer ( nsclc ) . the study group comprised 183 patients newly diagnos...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : hyponatraemia is the most commonly encountered electrolyte abnormality in hospitalised patients particularly in the intensive care unit ( icu ) . in...
### Summary: : background and aims : conivaptan , a vasopressin receptor antagonist , is commonly used for the treatment of euvolaemic , hypervolaemic hyponatraemia . usually , an intravenous ( iv ) bolus followed by infusion is administered for many days . we decided to assess the effectiveness of single dose co...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the introduction and subsequent sustained global spread in the human population of influenza a viruses with a novel hemagglutinin ( ha ) subtype lea...
### Summary: : until 2001 , h6n1 influenza viruses in the hong kong bird markets were represented by a single stable a / teal / hong kong / w312/97-like lineage . beginning in 2001 , despite a reduction in overall prevalence , an increase was observed in the number of h6 viruses isolated from chickens and other hosts...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : using best evidence to inform healthcare decisions is widely recognized as a key competency for all healthcare professionals . academic institut...
### Summary: : abstractaim : medical student educators play critical roles in evidence - based healthcare ( ebhc ) teaching and learning and as role models practicing ebhc . this study assessed their confidence to practice and teach ebhc , their attitude to ebhc and barriers to practicing and teaching ebhc.me...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the regulated expression of different families of retrotransposons and dna transposons has been described in different tissues and species . however...
### Summary: : transposable elements ( retrotransposons and dna transposons ) comprise a large proportion of animal genomes , for example 20% in d. melanogaster , 36% in x. tropicalis and 45% in humans . after invading a new genome , the transposable element increases its copy number and subsequently accumulates muta...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : we obtained formalin - fixed , paraffin - embedded tissue sections from 30 leiomyosarcoma patients at the university of texas md anderson cancer cen...
### Summary: : prune2 plays an important role in regulating tumor cell differentiation , proliferation , and invasiveness in neuroblastoma . our previous study revealed that prune2/obscn two - gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor . however...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : child abuse is defined as any physical or emotional injury which causes harm or substantive risk of harm to the child 's health or welfare . it in...
### Summary: : background : family violence , including child abuse , neglect , and domestic violence , is a public health problem . the aim of this study was to provide data on prevalence and factors of orofacial lesions relating child abuse in iran to lend evidence to support preventing child abuse.materials and ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : oncocytes are observed in lesions of several organs such as the thyroid , kidney , pancreas , ovary , liver , and salivary gland . in the salivary g...
### Summary: : multifocal adenomatous oncocytic hyperplasia ( maoh ) is a non - neoplastic lesion that is classified as oncocytosis . maoh is a rare entity of the parotid gland and accounts for approximately 0.1% of salivary gland lesions . here , we report a case of maoh of the parotid gland . the patient was ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : a 59 year - old female with a family history of mcd presented to our clinic with progressive loss of vision over a 40-year period . there were mul...
### Summary: : to report a novel mutation within the chst6 gene , as well as describe light and electron microscopic features of a case of macular corneal dystrophy . a 59-year old woman with macular corneal dystrophy in both eyes who had decreased visual acuity underwent penetrating keratoplasty . further studie...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : various methods including chemical , electro - chemical , and physical deposition techniques have been employed to synthesize 1d zno nanostructures ...
### Summary: : zno nanorod arrays are prepared on a silicon wafer through a multi - step hydrothermal process . the aspect ratios and densities of the zno nanorod arrays are controlled by adjusting the reaction times and concentrations of solution . the investigation of field emission properties of zno nanorod ar...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the adverse consequences of the acquired immune deficiency syndrome ( aids ) or t cell immunodeficiency provide evidence of the vital role of cytoto...
### Summary: : cytotoxic t - lymphocytes ( ctl ) are famous for their ability to kill tumor , allogeneic and virus - infected cells . however , an emerging literature has now demonstrated that ctl also possess the ability to directly recognize and kill bacteria , parasites , and fungi . here , we review past and ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : skin tissue integrity is a crucial factor to maintain the homeostasis generated through physical barriers , separating the organism from the environ...
### Summary: : skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components , accompanied by the accumulation of a vast number of myofibroblasts . scaring is strongly associated with inflammation and wound healing to regain tissue inte...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : acinetobacter baumannii is an opportunistic pathogen that is frequently involved in outbreaks of infection occurring mostly in intensive care units....
### Summary: : background : antibiotic - resistant acinetobacter nosocomial infection is a leading problem . it acts as an opportunistic pathogen to cause a wide spectrum of infection including nosocomial pneumonia , meningitis , endocarditis , skin and soft tissue infections , urinary tract infection , conjunctivi...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : bone grafting is common in neurosurgery for spinal fusion and in orthopedic reconstruction surgery for revision hip replacement , repairing skeletal...
### Summary: : abstractbone grafting is a commonly used orthopedic surgical procedure that will provide bone formation in bone defects or regions of defective bone healing . a major complication following bone grafting is a postoperative recipient graft site infection that is associated with substantial mortality a...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : globally , mother - to - child transmission of hiv-1 results in approximately 370 000 infant infections each year . hiv-1 early infant diagnosis ...
### Summary: : objectivethe purpose of this study is to assess the utility of web - based mobile technology monitoring tool , for ensuring linkages , and tracking of hiv - exposed child until 18 months of age.methodsthe early infant diagnosis ( eid ) follow - up system was designed as a tool for reminding the field ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : regulation of gene expression is fundamental for the coordinate synthesis , assembly and localization of the macromolecular structures of cells . ...
### Summary: : abstract.post-transcriptional regulation of gene expression plays important roles in diverse cellular processes such as development , metabolism and cancer progression . whereas many classical studies explored the mechanistics and physiological impact on specific mrna substrates , the recent developm...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : fetus in fetu ( fif ) was first described by meckel in the early 19th century , and it was defined as a mass containing a vertebral axis often assoc...
### Summary: : fetus - in - fetu ( fif ) is a rare congenital condition in which a fetiform mass is detected in the host abdomen and also in other sites such as the intracranium , thorax , head , and neck . this condition has been rarely reported in the literature . herein , we report the case of a fetus presenting...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : during october 1 , 2010july 31 , 2011 , the centers for disease control and prevention ( cdc ; atlanta , georgia , usa ) asked all state public heal...
### Summary: : during october 2010july 2011 , 1.0% of pandemic ( h1n1 ) 2009 viruses in the united states were oseltamivir resistant , compared with 0.5% during the 200910 influenza season . of resistant viruses from 201011 and 200910 , 26% and 89% , respectively , were from persons exposed to oseltamivir before spec...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the incidence of cutaneous melanoma ( cm ) is rapidly increasing in europe , especially in the caucasian population . incidences are known to vary...
### Summary: : background . the incidence of cutaneous melanoma is rapidly increasing in europe . active research is directed toward the identification of naevi as a risk factor . objective . the aim of our case - control study was to observe different numbers of moles and different mole typology associations i...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : head and neck squamous cell carcinoma ( hnscc ) is one of the most prevalent and lethal cancers worldwide ( argiris et al . , 2008 ) . despite recen...
### Summary: : human papillomavirus ( hpv ) infection is well established as an etiological agent responsible for a number of pathologies affecting the stratified epithelia of skin and anogenital sites . more recently , the infection by ( mucosal ) high - risk hpv types has also been found to be causally associated...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : crohn 's disease ( cd ) is a form of inflammatory bowel disease ( ibd ) affecting the entire gastrointestinal ( gi ) tract [ 14 ] . cd is characte...
### Summary: : crohn 's disease ( cd ) is a chronic inflammatory bowel disease that can be diagnosed at any age . there are two major patient groups based on diagnosis of this disease , before or after the age of 20 ( juvenile / adolescent or adult ) , with disease progression in adults usually milder than in juven...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : contaminated sites are extensively present in europe where approximately 250,000 sites require cleanup interventions , as listed by the european env...
### Summary: : the national environmental remediation programme in italy includes sites with documented contamination and associated potential health impacts ( national priority contaminated sites npcss ) . sentieri project , an extensive investigation of mortality in 44 npcss , considered the area of taranto , a ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : simultaneous bipolar dislocation of the clavicle is uncommon and unusual , although it has been documented as panclavicular dislocation , floating c...
### Summary: : introduction : simultaneous bipolar dislocation of the clavicle is uncommon and unusual , although it has been documented as panclavicular dislocation , floating clavicle , and complete dislocation of the clavicle . a review of the recent literature indicated that most bipolar clavicular dislocations...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : neural stem cells ( nscs ) are multipotent cells that can give rise to various cell types in the central nervous system ( cns ) , including neurons ...
### Summary: : in adult mammals , neural stem cells ( nscs ) are found in two niches of the brain ; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus . neurogenesis is a complex process that is tightly controlled on a molecular level . recently , mi...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : torus hyperplasia is a very rare condition also known as focal pyloric hypertrophy ( 1 ) . this lesion is caused by a circular muscle hypertrophy ...
### Summary: : primary or idiopathic hypertrophy of the pyloric muscle in adult , so called torus hyperplasia , is an infrequent but an established entity . it is caused by a circular muscle hypertrophy affecting the lesser curvature near the pylorus . since most of the lesions are difficult to differentiate from...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the incidence of non - hodgkin lymphoma ( nhl ) is rising worldwide and is higher in developed countries than in africa and asia . b cell non - ho...
### Summary: : b cell non - hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with hepatitis c virus ( hcv ) infection . the mechanism by which hcv infection leads to lymphoproliferative disorder remains unclear . our group established hcv transgenic mice that expressed the full hcv g...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : we studied 22 samples , from dogs , cattle , wildlife , and humans in cear , obtained from 1997 to 2003 ( table ) . samples were antigenically cha...
### Summary: : rabies viruses circulating in cear , brazil , were identified by molecular analysis to be related to variants maintained by dogs , bats , and other wildlife . most of these viruses are associated with human rabies cases . we document the emergence of a rabies virus variant responsible for an indepe...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : toxoplasma gondii ( t. gondii ) is an obligate intracellular protozoan parasite that causes toxoplasmosis , a usually asymptomatic disease in most i...
### Summary: : macrophage migration inhibitory factor ( mif ) mediates immunity against toxoplasma gondii infection by inducing inflammatory cytokines required to control the parasite replication . however , the role of this inflammatory mediator in the cell - mediated immune response against this infection is stil...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : implantation always involves penetration to the skin and damage of smaller or larger blood vessels through the surgical procedure and the implanted ...
### Summary: : design of blood compatible surfaces is required to minimize platelet surface interactions and increase the thromboresistance of foreign surfaces when they are used as biomaterials especially for artificial blood prostheses . in this study , single wall carbon nanotubes ( swcnts ) and zein fibrous nan...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the purpose of this study was to investigate the efficacy and safety of fixed dose combination ( fdc ) of olanzapine 5 mg and fluoxetine 20 mg in in...
### Summary: : objective : the purpose of this study was to investigate the efficacy and safety of fixed dose combination ( fdc ) of olanzapine 5 mg and fluoxetine 20 mg in indian patients with severe or treatment resistant depression.design : this was an open , non - comparative study of seven weeks duration with an...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : for ensuring post - endodontic restorations which provide tooth function and form with adequate force distribution , placement of fiber posts to the...
### Summary: : purposethe aim of this study was to evaluate whether the push - out bond strength varies between oval and circular fiber posts , and to examine the effect on the resin cement thicknesses around the posts.materials and methodseighteen mandibular premolar roots were separated into two groups for oval and...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : pediatric soft - tissue sarcomas ( stss ) account for approximately 7% of all childhood tumors . out though surgery is the mainstay of treatment ,...
### Summary: : infantile fibrosarcoma ( ifs ) is a rare soft - tissue sarcoma originating from extremities and occasionally from axial soft tissue . the prognosis is good with favorable long - term survival . it is rarely metastasizing tumor , the chances being lesser with ifs originating from extremities . use...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : we studied 1,297 patients with type 1 diabetes from the nationwide finnish diabetic nephropathy study ( finndiane ) . patients were required to ha...
### Summary: : objectivemannose - binding lectin ( mbl ) is an essential component of the acute - phase immune response and may thus play a role in the pathogenesis of type 1 diabetes and diabetic nephropathy . the serum concentration of mbl is mainly genetically determined , and elevated concentrations have been a...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : gwas2 included 450 unrelated generalized vitiligo patients ( cases ) of non - hispanic / latino european ancestry ( eur ) from north america and eur...
### Summary: : in previous linkage and genome - wide association studies we identified 17 susceptibility loci for generalized vitiligo . by a second genome - wide association study , meta - analysis , and independent replication study , we have now identified 13 additional vitiligo - associated loci , including oca...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : now they need more attention because as the average life expectancy , elderly population , and subsequent resulting osteoporosis continue to increas...
### Summary: : background . intertrochanteric fractures of the proximal femur are one of the most common fractures encountered , and dynamic hip screw with a side plate is the standard treatment . we compared a minimally invasive surgical technique with the conventional surgical technique used in the fixation of in...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : nucleic acids are highly attractive class of therapeutics due to their potential to regulate any selected gene of interest . given their capacity to...
### Summary: : nucleic acid therapy can be beneficial for the local treatment of gastrointestinal diseases that currently lack appropriate treatments . indeed , several oligonucleotides ( ons ) are currently progressing through clinical trials as potential treatments for inflammatory bowel diseases . however , due ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : increasing numbers of aesthetic procedures - especially cosmetic nonsurgical injection procedures - are performed every year ( 1 ) . these procedu...
### Summary: : cosmetic facial filler - related ophthalmic artery occlusion is rare but is a devastating complication , while the exact pathophysiology is still elusive . cerebral angiography provides more detailed information on blood flow of ophthalmic artery as well as surrounding orbital area which can not be c...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : with the ever increasing importance of clinical effectiveness , audit and quality assurance ; it is becoming mandatory to grade one 's own treatm...
### Summary: : objective : the aim of the study was to evaluate the effect of post- treatment critical evaluation on the quality of orthodontic care in a postgraduate orthodontic clinic.materials and methods : orthodontic treatment outcome of 109 consecutively treated cases was evaluated in phase - i evaluation . fol...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: :
### Summary: : concentrations of ambient pm2.5 ( particulate matter < 2.5 microm in aerodynamic diameter ) were associated with increased mortality in two prospective cohort studies . in this paper , i assess whether the weight of the evidence supports a causal association . i assumed the study population in each...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: :
### Summary: : beryllium was released into the air from routine operations and three accidental fires at the rocky flats plant ( rfp ) in colorado from 1958 to 1989 . we evaluated environmental monitoring data and developed estimates of airborne concentrations and their uncertainties and calculated lifetime cancer ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the motility of nk cells in tissue or tumor microenvironment is likely driven by chemotactic signaling resulting in an approximation to key sites of...
### Summary: : natural killer ( nk ) cell - mediated cytotoxicity is governed by the formation of a lytic immune synapse in discrete regulated steps , which give rise to an extensive array of cellular checkpoints in accessing nk cell - mediated cytolytic defense . appropriate progression through these cell biologic...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : appropriate timing of treatment is the key to successful intensive care ; treatment that is delayed could be as detrimental as treatment that is pre...
### Summary: : appropriate timing of treatment assumes particular importance in critical care . lange and colleagues recently reported on the time course of the different nitric oxide synthase ( nos ) isoforms , nitrosative stress , and poly(adp - ribosylation ) during pseudomonas aeruginosa pneumonia - induced ovi...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : steroid hormones have been traditionally associated with regulation of peripheral organs , associated with stress ( corticosterone ) or with gonadal...
### Summary: : several new observations have shifted the view of the hippocampus from a structure in charge of cognitive processes to a brain area that participates in the formation of emotional memories , in addition to its role in cognition . specifically , while the dorsal hippocampus is involved in the processing...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : primary amenorrhea is the absence of menstruation and secondary sexual characteristics in phenotypic women aged 14 years or older . common hormona...
### Summary: : background : primary amenorrhea is defined as the absence of menstruation and secondary sexual characteristics in phenotypic women aged 14 years or older . hormonal disorders are main causes of primary amenorrhea . common hormonal cause of primary amenorrhea includes pituitary dysfunction and absen...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : we report the case of a 13yearold boy with neuromuscular proximal thoracic scoliosis who was found to have significant torsion of the left main bron...
### Summary: : key clinical messagepulmonary function tests such as flowvolume loops and reconstructive radiological imaging may aid the detection of large airway obstruction prior to corrective surgery for severe scoliosis . intraoperative use of halogravity traction may help to reduce the severity of the scoliosi...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : portal hypertension , always accompanies by cirrhosis , can lead to lots of complications including varices hemorrhage , ascites , hypersplenism and...
### Summary: : background : the purpose of this article was to clarify the optimal management concerning transjugular intrahepatic portosystemic shunts ( tipss ) and surgical shunting in treating portal hypertension.methods:all databases , including cbm , cnki , wfpd , medline , embase , pubmed and cochrane up to feb...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the frequency of prenatal hydronephrosis diagnosed by ultrasound has been reported to be 0.65.4% of newborns [ 39 ] . among infants with hydronephro...
### Summary: : backgroundhydronephrosis is a common congenital condition . the detection of fetal hydronephrosis by ultrasound presents a treatment dilemma . this study aims to examine postnatal follow - up and treatment for hydronephrosis diagnosed prenatally.material/methodsthis was a retrospective study of 210...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : d - penicillamine has been known as one of the agents that are able to induce pemphigus ( 1,2 ) . n-(2-mercapto-2-methylpropionyl)-l - cysteine ] ...
### Summary: : bucillamine is a disease modifying anti - rheumatic drug , structurally similar to d - penicillamine . although d - penicillamine - induced pemphigus has been not infrequently demonstrated , pemphigus associated with bucillamine was rarely reported . we describe a patient complicating pemphigus vul...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the - and -lactam scaffolds are found in various biologically relevant compounds . additionally , these core structures are crucial intermedia...
### Summary: : sulfone - substituted - and -lactams have been prepared in a single step with high diastereoselectivity . sulfonylglutaric anhydrides produce intermediates that readily decarboxylate to provide -lactams with high diastereoselectivity . substituents at the 3- or 4-position of the glutaric ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : almost 40%60% of patients with colorectal cancer ( crc ) develop metastasis , predominantly in the liver . tumor angiogenesis has been implicated ...
### Summary: : background . colorectal cancer ( crc ) is the most common form of cancer diagnosed in australia across both genders . approximately , 40%60% of patients with crc develop metastasis , the liver being the most common site . almost 70% of crc mortality can be attributed to the development of liver met...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : carotid blow - out syndrome is the most feared complication in head and neck surgery . the syndrome occurs in 3% to 4% of all head and neck cancer...
### Summary: : abstractthe patient had thyroid cancer and underwent subtotal thyroidectomy . local recurrence occurred on both sides 5 years and 6 months later . the sterno - hyoid muscle and sterno - thyroid muscle were severed and the tumor around the cricoid cartilage was removed . the tumor extended into th...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : errors in the health care system are due to a diverse interaction of human behavior , socio - cultural aspects , technical aspects of the system , a...
### Summary: : background : a limited framework of incident reporting exists in most of the health care system in pakistan . this poses a risk to the patient population and therefore there is a need to find the causes behind the lack of such a system in healthcare settings in pakistan.aims:to determine the attitude...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : sulfonamides and sulfones serve both as useful intermediates in organic synthesis and as important target molecules in their own right . for e...
### Summary: : the development of efficient methods for the generation of enantioenriched sulfonamides and sulfones is an important objective for fields such as organic synthesis and medicinal chemistry ; however , there have been relatively few reports of direct catalytic asymmetric approaches to controlli...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : gold nanorods ( gnrs ) are anisotropic particles whose surface plasmon modes can be tuned as a function of aspect ratio , with optical resonance...
### Summary: : stable aqueous dispersions of citrate - stabilized gold nanorods ( cit - gnrs ) have been prepared in scalable fashion by surfactant exchange from cetyltrimethylammonium bromide ( ctab)-stabilized gnrs , using polystyrenesulfonate ( pss ) as a detergent . the surfactant exchange process was...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : many psychoactive substances have therapeutic function as analgesics or anesthetics and high addiction potential ( 1 ) . are commonly used on the ...
### Summary: : background : psychoactive substances affect mainly central nervous system and brain function causing changes in behavior.objectives:the purpose of this study was to determine the effects of different psychoactive substances on serum biochemical parameters.patients and methods : the study included 324 d...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : research interest is increasing in biomaterials with the potential to stimulate bone healing have gained interest to improve treatment outcome for p...
### Summary: : backgroundthe aim of the current study was to measure and compare the effect of various biomaterials for the healing of osteoporotic bone defects in the rat femur using 18f - sodium fluoride dpet-ct.material/methodsosteoporosis was induced by ovariectomy and a calcium - restricted diet . after 3 mont...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : m. tuberculosis isolates were obtained from the laboratory of mycobacteriology of the institut pasteur de tunis as part of the national tuberculosis...
### Summary: : multidrug - resistant tuberculosis was diagnosed in 21 hiv - negative , nonhospitalized male patients residing in northern tunisia . a detailed investigation showed accelerated transmission of a mycobacterium tuberculosis clone of the haarlem type in 90% of all patients . this finding highlights th...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the goals of surgical management include correction and maintenance of sagittal and coronal alignment , establishment of length and rotation , and e...
### Summary: : aim . to evaluate the clinical use of blocking screws as a supplement to stability in distal tibial metaphyseal fractures treated with statically locked intramedullary nail . main outcome measurement . alignment and reduction preoperatively , postoperatively , and at healing were the main outcome m...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : this was a retrospective study that included consecutive cases undergoing surgery for primary rhegmatogenous rd in patients with pseudophakia after ...
### Summary: : purposeto evaluate the clinical features and surgical outcomes for primary rhegmatogenous retinal detachments ( rds ) in patients with pseudophakia after phacoemulsification.methodsthe medical records of patients with pseudophakia after phacoemulsification and intraocular lens implantation who had unde...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the patient was an 11-year - old boy with no family history of optic neuropathy or dystonia . he presented with focal dystonia in the right upper ...
### Summary: : this article reports the case of an 11-year - old boy with progressive dystonia caused by the homoplasmic g14459a mitochondrial dna mutation . the patient presented with focal dystonia in the right upper limb at 3 years of age , which progressed over 4 years to exhibit dystonia in both the upper and ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : fibrous dysplasia of bone is characterized by the replacement of medullary bone with fibro - osseous tissue . this results in the distortion and o...
### Summary: : mccune albright syndrome ( mas ) comprises a triad of fibrous dysplasia of bone , caf - au - lait macule , and endocrinopathy . the disease is due to activating mutation of g protein - coupled receptor leading to hyperfunction of glands . hansen 's disease is caused by infection with mycobacterium...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : pseudouridine ( ) is the most abundant post - transcriptional rna base modification and the enzymes responsible for this isomerization of uridine a...
### Summary: : pseudouridine synthase 1 ( pus1p ) is an unusual site - specific modification enzyme in that it can modify a number of positions in trnas and can recognize several other types of rna . no consensus recognition sequence or structure has been identified for pus1p . human pus1p was used to determine w...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : midfacial defects are classified as midline midfacial defects , that include the nose and/or upper lip ; and lateral defects , which include the orb...
### Summary: : facial prosthesis is generally considered over surgical reconstruction to restore function and appearance in patients with facial defects that resulted from cancer resection . retention of the prosthesis is challenging due to its size and weight . retention can be achieved by using medical grade ad...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the incidence of well - differentiated thyroid carcinoma , particularly papillary cancer , has been increasing since the last 2030 years . the surve...
### Summary: : clinical and pathological characteristics of incidental papillary thyroid microcancer cases , surgical , medical , and nuclear treatment methods , and patients ' outcome were studied during follow - up period of 102 months . we studied 37 patients with incidental papillary thyroid microcancer ( i - p...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : misdiagnosis of bipolar disorder is a potentially serious problem for patients , which sometimes leads to inappropriate treatment.1 however , it is ...
### Summary: : misdiagnosis of bipolar disorder is a serious , but not unusual problem for patients . nevertheless , there are few biomarkers for distinguishing unipolar and bipolar disorder . near - infrared spectroscopy ( nirs ) is a noninvasive and useful method for the measurement of hemoglobin concentration ch...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : chronic subdural hematoma ( csdh ) is a rare complication of unruptured aneurysm clipping surgery5,12 ) . because csdh signs and symptoms may appear...
### Summary: : objectivechronic subdural hematoma ( csdh ) is a rare complication of unruptured aneurysm clipping surgery . the purpose of this study was to identify the incidence and risk factors of postoperative csdh after surgical clipping for unruptured anterior circulation aneurysms.methodsthis retrospective s...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : helicobacter pylori have infected nearly half of the world s population . in the developing countries , more than 90% of adults are typically infe...
### Summary: : background : persistent helicobacter pylori infection confers an increased risk for serious illnesses such as peptic ulcers and gastric cancer . various cytokines are involved in the regulation of inflammatory immune response in h. pylori - infected gastric mucosa.objectives:the current study aimed t...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : tuberous sclerosis complex ( tsc ) is a genetic disorder that can affect almost all organ systems . renal manifestations occur with high frequency...
### Summary: : renal calculi in patients with renal angiomyolipomas are difficult to treat because of the hemorrhagic potential of these tumors . we describe the case of a 65-year - old man having tuberous sclerosis complex - associated multifocal renal angiomyolipomas with a large renal calculus . the patient pres...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the diagnosis of unexplained syncopal episodes and sustained palpitations remains a difficult task in clinical cardiology . standard 24 h holter m...
### Summary: : aimssynarr - flash study ( monitoring of syncopes and/or sustained palpitations of suspected arrhythmic origin ) is an international , multicentre , observational , prospective trial designed to evaluate the role of external 4-week electrocardiogram ( ecg ) monitoring in clinical work - up of unexplain...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : conflict of interest : jjf is a consultant for nkt therapeutics and receives research funding from nkt therapeutics and astellas . red cell transf...
### Summary: : in patients with sickle cell disease , hyperhemolysis is a rare but life - threatening complication of transfusion . in this case report , we describe a 61 year - old woman with hemoglobin sickle cell ( sc ) disease and history of alloimmunization who developed hyperhemolysis associated with a transfus...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the vertebral fractures is the most common complications of osteoporosis.13 ) these fractures result in significant mortality and morbidity includin...
### Summary: : we experienced a 73-year - old male with lumbar nerve root compression due to leakage of bone cement after vertebroplasty . he was underwent vertebroplasty for acute osteoporotic l4 compression fracture at our hospital . after vertebroplasty , his back pain was improved but right leg pain was newly...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : stridor in children is usually due to airway pathology but neurological conditions causing stridor are not infrequent . in cases with an underlying ...
### Summary: : stridor in children is usually , but not always caused by airway pathology . the anesthesiologists should have a sound knowledge of the neurological associations of stridor and its management . in such cases , prompt treatment of the neurological pathology usually resolves the stridor and may preve...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the success of dental implant is primarily based on good osseointegration , which depends on the biocompatibility of the implant material and implan...
### Summary: : purposethis study was performed to define attachment and growth behavior of osteoblast - like cells and evaluate the gene expression on zirconia compared to titanium.materials and methodsmc3t3-e1 cells were cultured on ( 1 ) titanium and ( 2 ) zirconia discs . the tetrazolium - based colorimetric ass...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : techniques for instrumented fixation and fusion of the cervical spine have rapidly advanced in the past 30 years . these techniques have helped su...
### Summary: : study design : a multicenter , retrospective case series.objective:in the past several years , screw fixation of the cervical spine has become commonplace . for the most part , this is a safe , low - risk procedure . while rare , screw backout or misplaced screws can lead to morbidity and increased c...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : biological variation allows for a unique craniofacial character and many asymmetries found in each individual . a neurodevelopmental disorder has ...
### Summary: : background : abnormal brain development due to neurodevelopmental disorders in children has always been an important concern , but yet has to be considered as a significant public health problem , especially in the low- and middle - income countries including nigeria.aims:the aim of this study is to de...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : the verbal informed patient consent was acquired for the case report publication during the acute rehabilitation . institutional review board appr...
### Summary: : this case report describes the detection of homonymous hemianopsia and delirium during the admission physical examination of a patient with esophageal adenocarcinoma , resulting in the new diagnosis of subacute hemorrhagic stroke . the poststroke visual field defect can result in significant disabili...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : higher energy intake than expenditure causes excessive accumulation of fat and leads to the development of obesity and associated metabolic disorder...
### Summary: : backgroundfibroblast growth factor 21 ( fgf21 ) belongs to the large family of fibroblast growth factors ( fgfs ) . even though fgf signaling has been mainly implicated in developmental processes , recent studies have demonstrated that fgf21 is an important regulator of whole body energy expenditure ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : endometriosis affecting the rectum accounts for a small but significant group of women with severe pelvic pain . perhaps because of the inadequacy o...
### Summary: : background : anterior rectal resection is sometimes necessary to treat deeply infiltrating rectovaginal endometriosis . we describe a completely laparoscopic approach as a new way of excising rectal endometriosis that can be used without opening any part of the rectum . this avoids opening the abdome...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : thymic carcinoma is an aggressive anterior mediastinal malignancy that can cause severe chest pain , although its incidence is rare . echocardiogr...
### Summary: : we report a case of thymic carcinoma that was initially detected by echocardiography in an 80-year - old male who visited the emergency room for chest pain and had a history of myocardial infarction and percutaneous coronary intervention . transthoracic echocardiography showed a huge extracardiac mas...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : bromodomains are epigenetic readers that specifically recognize acetyl - lysine ( kac ) marks on proteins . targeting this protein interaction...
### Summary: : the p300/cbp - associated factor plays a central role in retroviral infection and cancer development , and the c - terminal bromodomain provides an opportunity for selective targeting . here , we report several new classes of acetyl - lysine mimetic ligands ranging from mm to low micromolar ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : every human voice is unique as it was found to be quantitatively composed of components called phonemes that have a pitch , cadence , and inflecti...
### Summary: : voice biometrics has a long history in biosecurity applications such as verification and identification based on characteristics of the human voice . the other application called voice classification which has its important role in grouping unlabelled voice samples , however , has not been widely stu...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : medical doctors move across borders being motivated by higher salaries , better working conditions , new professional experience , and training and ...
### Summary: : this chapter aims at providing an insight into some major aspects linked to migration of medical doctors within europe . the article describes main factors which contribute to doctors migration . further , the current and future mobility trends in europe are discussed . a major part of this chapt...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : imipramine was found to improve mood while being used in a protocol to search for an antipsychotic : ' iproniazid , a drug used in the treatment of ...
### Summary: : the current clinical use of psychotropic drugs is transnosologically oriented . this is facilitated by the current classification of mental disorders ( international classification of diseases , 10th revision [ icd-10 ] ) and is perhaps justified if depression and psychosis ( taken here as examples )...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : africa , the population size of the city of tshwane in 2011 was roughly equal to 3 million . the city is home to over 5,000 businesses out of whic...
### Summary: : objective . the objective was to investigate factors that affect the efficient management of solid waste produced by commercial businesses operating in the city of pretoria , south africa . methods . data was gathered from 1,034 businesses . efficiency in solid waste management was assessed by us...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : parkinson 's disease ( pd ) is a neurodegenerative condition characterised clinically as a movement disorder consisting of bradykinesia , rigidity a...
### Summary: : parkinson 's disease ( pd ) is a neurodegenerative condition which causes a characteristic movement disorder secondary to loss of dopaminergic neurons in the substanitia nigra . the motor disorder responds well to dopamine - replacement therapies , though these result in significant adverse effects d...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : panoramic radiography is a cost - effective , low - dose method used in dental radiology for evaluating oral health status in routine dental practic...
### Summary: : purposethe aim of this study was to determine the frequency of significant panoramic radiographic findings and eventual treatment requirements before conventional or implant supported prosthetic treatment in asymptomatic edentulous patients.materials and methodsa total of 743 asymptomatic edentulous pa...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : spinal epidural lipomatosis ( sel ) is a rare disease that is characterized by pathologic overgrowth of lumbar or thoracic epidural fat tissue . a...
### Summary: : spinal epidural lipomatosis ( sel ) is an abnormal localized accumulation of fat tissues in the epidural space . it is strongly related with steroid administration . the symptoms of sel are various and range from back pain to paraplegia . in severe cases , decompressive laminectomy is the choice ...
<s> [INST] <<SYS>> You a helpful assistant capable of providing accurate and concise responses. You will assist me in generating Summary.<</SYS>> [/INST] <s> ### Text: : increased long - term survival following effective treatment of childhood lymphomas has placed greater emphasis on residual sequelae of therapy for ...
### Summary: : objectives . we studied long - term effects of therapy for childhood lymphoma on cardiac function . design and patients . we prospectively evaluated 45 survivors of childhood lymphoma , using clinical parameters , electrocardiography and echocardiography . further comparisons were made between lymp...