Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
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 Community
1
paragraph_index
int64
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int64
cites
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pmid
int64
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sentences
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list
sent_len
int64
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float64
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1
DISCUSSION
1
Rosen et al., 1975
[ "bib22", "bib23", "bib33", "bib12", "bib14", "bib25", "bib12", "bib14", "bib25", "bib12", "bib35", "bib26", "bib31" ]
12,601,084
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Second, the recovery time course of the neutral form of flecainide is fast (too fast to accumulate the UDB) and is comparable to recovery time course of fast Na inactivation (Hille, 1977a; Yeh and Tanguy, 1985).
[ "Rosen et al., 1975", "Rosen and Wit, 1983", "Wit and Rosen, 1983", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Yeh and Tanguy, 1985", "Strichartz, 1973", "Wang et al., 1995" ]
211
41,919
0
false
Second, the recovery time course of the neutral form of flecainide is fast (too fast to accumulate the UDB) and is comparable to recovery time course of fast Na inactivation.
[ "Hille, 1977a; Yeh and Tanguy, 1985" ]
Second, the recovery time course of the neutral form of flecainide is fast and is comparable to recovery time course of fast Na inactivation.
true
true
true
true
true
7,234
1
DISCUSSION
1
Rosen et al., 1975
[ "bib22", "bib23", "bib33", "bib12", "bib14", "bib25", "bib12", "bib14", "bib25", "bib12", "bib35", "bib26", "bib31" ]
12,601,084
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
As a result, upon dissociation neutral flecainide simply diffuses away through a hydrophobic pathway.
[ "Rosen et al., 1975", "Rosen and Wit, 1983", "Wit and Rosen, 1983", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Yeh and Tanguy, 1985", "Strichartz, 1973", "Wang et al., 1995" ]
101
41,920
0
false
As a result, upon dissociation neutral flecainide simply diffuses away through a hydrophobic pathway.
[]
As a result, upon dissociation neutral flecainide simply diffuses away through a hydrophobic pathway.
true
true
true
true
true
7,234
1
DISCUSSION
1
Rosen et al., 1975
[ "bib22", "bib23", "bib33", "bib12", "bib14", "bib25", "bib12", "bib14", "bib25", "bib12", "bib35", "bib26", "bib31" ]
12,601,084
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This possibility is likely as the recovery from NU-FL block in solutions buffered to pH 5.5, when the ratio of neutral to charged forms of NU-FL are reversed, is greatly slowed, consistent with the higher UDB level at the same condition.
[ "Rosen et al., 1975", "Rosen and Wit, 1983", "Wit and Rosen, 1983", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Yeh and Tanguy, 1985", "Strichartz, 1973", "Wang et al., 1995" ]
237
41,921
0
false
This possibility is likely as the recovery from NU-FL block in solutions buffered to pH 5.5, when the ratio of neutral to charged forms of NU-FL are reversed, is greatly slowed, consistent with the higher UDB level at the same condition.
[]
This possibility is likely as the recovery from NU-FL block in solutions buffered to pH 5.5, when the ratio of neutral to charged forms of NU-FL are reversed, is greatly slowed, consistent with the higher UDB level at the same condition.
true
true
true
true
true
7,234
1
DISCUSSION
1
Rosen et al., 1975
[ "bib22", "bib23", "bib33", "bib12", "bib14", "bib25", "bib12", "bib14", "bib25", "bib12", "bib35", "bib26", "bib31" ]
12,601,084
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Thus, our results clearly indicate that the charged form of flecainide is the active form that underlies UDB, which is the reported mechanism of action of lidocaine (Strichartz, 1973; Wang et al., 1995).
[ "Rosen et al., 1975", "Rosen and Wit, 1983", "Wit and Rosen, 1983", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Hondeghem and Katzung, 1977", "Starmer et al., 1984", "Hille, 1977a", "Yeh and Tanguy, 1985", "Strichartz, 1973", "Wang et al., 1995" ]
203
41,922
0
false
Thus, our results clearly indicate that the charged form of flecainide is the active form that underlies UDB, which is the reported mechanism of action of lidocaine.
[ "Strichartz, 1973; Wang et al., 1995" ]
Thus, our results clearly indicate that the charged form of flecainide is the active form that underlies UDB, which is the reported mechanism of action of lidocaine.
true
true
true
true
true
7,234
2
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
If flecainide is 99% ionized at physiological pH, how does external flecainide application result in internal access of the charged form of the drug to the inner mouth of the channel pore?
null
188
41,923
0
false
null
null
If flecainide is 99% ionized at physiological pH, how does external flecainide application result in internal access of the charged form of the drug to the inner mouth of the channel pore?
true
true
true
true
true
7,235
2
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
The results presented in Fig.
null
29
41,924
0
false
null
null
The results presented in Fig.
true
true
true
true
true
7,235
2
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
9 provide a clue to this question.
null
34
41,925
0
false
null
null
9 provide a clue to this question.
false
false
true
true
false
7,235
2
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
Because flecainide, applied outside the area under the patch electrode, blocked channels recorded in cell-attached patches, the drug had to diffuse across the cell membrane in order to reach the patched channels.
null
212
41,926
0
false
null
null
Because flecainide, applied outside the area under the patch electrode, blocked channels recorded in cell-attached patches, the drug had to diffuse across the cell membrane in order to reach the patched channels.
true
true
true
true
true
7,235
2
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
This must occur via the neutral flecainide component, which crosses the membrane and then equilibrates in the intracellular solution again in neutral (1%) and charged (99%) forms.
null
179
41,927
0
false
null
null
This must occur via the neutral flecainide component, which crosses the membrane and then equilibrates in the intracellular solution again in neutral (1%) and charged (99%) forms.
true
true
true
true
true
7,235
2
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
A similar sequence must also occur across the membrane of the patch, but in this case both the difference in membrane area (patch to whole cell) and the volume of the absorbing solution (pipette volume compared with volume of the cell), would limit the drug concentration of the pipette solution.
null
296
41,928
0
false
null
null
A similar sequence must also occur across the membrane of the patch, but in this case both the difference in membrane area (patch to whole cell) and the volume of the absorbing solution (pipette volume compared with volume of the cell), would limit the drug concentration of the pipette solution.
true
true
true
true
true
7,235
2
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
That this is likely the case is evidenced by the rapid reversibility of drug block, which occurs when the extra-patch flecainide is removed in these experiments (Fig.
null
166
41,929
0
false
null
null
That this is likely the case is evidenced by the rapid reversibility of drug block, which occurs when the extra-patch flecainide is removed in these experiments (Fig.
true
true
true
true
true
7,235
3
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
An indirect role of the neutral flecainide component in the development of use-dependent block of externally applied drug is also supported by the experiments of Figs.
null
167
41,930
0
false
null
null
An indirect role of the neutral flecainide component in the development of use-dependent block of externally applied drug is also supported by the experiments of Figs.
true
true
true
true
true
7,236
3
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
8 and 9, which show that QX-FL is not effective when applied externally outside of the patched area (Fig.
null
105
41,931
0
false
null
null
8 and 9, which show that QX-FL is not effective when applied externally outside of the patched area (Fig.
false
false
true
true
false
7,236
3
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
9), but when applied intracellularly, as effectively as extracellularly applied flecainide (Fig.
null
96
41,932
0
false
null
null
9), but when applied intracellularly, as effectively as extracellularly applied flecainide (Fig.
false
false
true
true
false
7,236
3
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
The simplest interpretation of these results is that neutral flecainide diffuses across the lipid bilayer of the cell membrane, equilibrates in the intracellular compartment where, as in the extracellular solution, 99% of the flecainide molecules in equilibrium are ionized.
null
274
41,933
0
false
null
null
The simplest interpretation of these results is that neutral flecainide diffuses across the lipid bilayer of the cell membrane, equilibrates in the intracellular compartment where, as in the extracellular solution, 99% of the flecainide molecules in equilibrium are ionized.
true
true
true
true
true
7,236
3
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
Use-dependent block that occurs
null
31
41,934
0
false
null
null
Use-dependent block that occurs
true
true
false
true
false
7,236
3
DISCUSSION
0
null
null
12,601,084
NA|NA|NA|NA|NA
, most likely develops as a consequence of the intracellular charged flecainide molecules.
null
90
41,935
0
false
null
null
, most likely develops as a consequence of the intracellular charged flecainide molecules.
false
false
true
true
false
7,236
4
DISCUSSION
1
Ragsdale et al., 1994
[ "bib20", "bib21", "bib30", "bib7", "bib34", "bib7", "bib34", "bib18", "bib9" ]
12,601,084
NA|NA|NA|NA|NA|NA|NA|NA|NA
As has previously been the case for the quaternary lidocaine analogue QX-314, QX-FL provides unique insight into the access of a charged flecainide analogue to a common local anesthetic receptor-binding site on the Na+ channel.
[ "Ragsdale et al., 1994", "1996", "Wang et al., 1998", "Catterall, 2002", "Yarov-Yarovoy et al., 2002", "Catterall, 2002", "Yarov-Yarovoy et al., 2002", "Perozo et al., 1999", "del Camino et al., 2000" ]
227
41,936
0
false
As has previously been the case for the quaternary lidocaine analogue QX-314, QX-FL provides unique insight into the access of a charged flecainide analogue to a common local anesthetic receptor-binding site on the Na+ channel.
[]
As has previously been the case for the quaternary lidocaine analogue QX-314, QX-FL provides unique insight into the access of a charged flecainide analogue to a common local anesthetic receptor-binding site on the Na+ channel.
true
true
true
true
true
7,237
4
DISCUSSION
1
Ragsdale et al., 1994
[ "bib20", "bib21", "bib30", "bib7", "bib34", "bib7", "bib34", "bib18", "bib9" ]
12,601,084
NA|NA|NA|NA|NA|NA|NA|NA|NA
Studies using alanine-scanning mutagenesis have provided a detailed picture of components of a local anesthetic receptor site for which residues on the S6 segments of domains I, III, and IV contribute (Ragsdale et al., 1994, 1996; Wang et al., 1998; Catterall, 2002; Yarov-Yarovoy et al., 2002).
[ "Ragsdale et al., 1994", "1996", "Wang et al., 1998", "Catterall, 2002", "Yarov-Yarovoy et al., 2002", "Catterall, 2002", "Yarov-Yarovoy et al., 2002", "Perozo et al., 1999", "del Camino et al., 2000" ]
295
41,937
0
false
Studies using alanine-scanning mutagenesis have provided a detailed picture of components of a local anesthetic receptor site for which residues on the S6 segments of domains I, III, and IV contribute.
[ "Ragsdale et al., 1994, 1996; Wang et al., 1998; Catterall, 2002; Yarov-Yarovoy et al., 2002" ]
Studies using alanine-scanning mutagenesis have provided a detailed picture of components of a local anesthetic receptor site for which residues on the S6 segments of domains I, III, and IV contribute.
true
true
true
true
true
7,237
4
DISCUSSION
1
Ragsdale et al., 1994
[ "bib20", "bib21", "bib30", "bib7", "bib34", "bib7", "bib34", "bib18", "bib9" ]
12,601,084
NA|NA|NA|NA|NA|NA|NA|NA|NA
Alanine-scanning mutagenesis indicates that residues in at least domains III and IV that contribute to the receptor site are likely to face the inner pore region of the channel (Catterall, 2002; Yarov-Yarovoy et al., 2002), and that rotational movement of S6 segments during activation and inactivation are likely to alt...
[ "Ragsdale et al., 1994", "1996", "Wang et al., 1998", "Catterall, 2002", "Yarov-Yarovoy et al., 2002", "Catterall, 2002", "Yarov-Yarovoy et al., 2002", "Perozo et al., 1999", "del Camino et al., 2000" ]
435
41,938
0
false
Alanine-scanning mutagenesis indicates that residues in at least domains III and IV that contribute to the receptor site are likely to face the inner pore region of the channel, and that rotational movement of S6 segments during activation and inactivation are likely to alter access to this site from the intracellular ...
[ "Catterall, 2002; Yarov-Yarovoy et al., 2002", "Perozo et al., 1999; del Camino et al., 2000" ]
Alanine-scanning mutagenesis indicates that residues in at least domains III and IV that contribute to the receptor site are likely to face the inner pore region of the channel, and that rotational movement of S6 segments during activation and inactivation are likely to alter access to this site from the intracellular ...
true
true
true
true
true
7,237
5
DISCUSSION
1
Liu et al., 2002
[ "bib17", "bib17" ]
12,601,084
NA|NA
We have shown previously that flecainide UDB requires channels to open but that block is very sensitive to alterations in channel inactivation (Liu et al., 2002).
[ "Liu et al., 2002", "Liu et al., 2002" ]
162
41,939
1
false
We have shown previously that flecainide UDB requires channels to open but that block is very sensitive to alterations in channel inactivation.
[ "Liu et al., 2002" ]
We have shown previously that flecainide UDB requires channels to open but that block is very sensitive to alterations in channel inactivation.
true
true
true
true
true
7,238
5
DISCUSSION
1
Liu et al., 2002
[ "bib17", "bib17" ]
12,601,084
NA|NA
We now find that ionized flecainide, which accounts for the distinct UDB of the drug, gains access to its receptor via an intracellular pathway after channels open.
[ "Liu et al., 2002", "Liu et al., 2002" ]
164
41,940
0
false
We now find that ionized flecainide, which accounts for the distinct UDB of the drug, gains access to its receptor via an intracellular pathway after channels open.
[]
We now find that ionized flecainide, which accounts for the distinct UDB of the drug, gains access to its receptor via an intracellular pathway after channels open.
true
true
true
true
true
7,238
5
DISCUSSION
1
Liu et al., 2002
[ "bib17", "bib17" ]
12,601,084
NA|NA
Mutation of the key Phe residue in the local anesthetic receptor disrupts channel block by lidocaine, flecainide, neutral flecainide (NU-FL), and ionized flecainide (QX-FL).
[ "Liu et al., 2002", "Liu et al., 2002" ]
173
41,941
0
false
Mutation of the key Phe residue in the local anesthetic receptor disrupts channel block by lidocaine, flecainide, neutral flecainide (NU-FL), and ionized flecainide (QX-FL).
[]
Mutation of the key Phe residue in the local anesthetic receptor disrupts channel block by lidocaine, flecainide, neutral flecainide, and ionized flecainide.
true
true
true
true
true
7,238
5
DISCUSSION
1
Liu et al., 2002
[ "bib17", "bib17" ]
12,601,084
NA|NA
Together, these results are very consistent with a common receptor shared by lidocaine and flecainide, access to which is restricted by differences in ionization of the two compounds as predicted by the modulated receptor hypothesis.
[ "Liu et al., 2002", "Liu et al., 2002" ]
233
41,942
0
false
Together, these results are very consistent with a common receptor shared by lidocaine and flecainide, access to which is restricted by differences in ionization of the two compounds as predicted by the modulated receptor hypothesis.
[]
Together, these results are very consistent with a common receptor shared by lidocaine and flecainide, access to which is restricted by differences in ionization of the two compounds as predicted by the modulated receptor hypothesis.
true
true
true
true
true
7,238
5
DISCUSSION
1
Liu et al., 2002
[ "bib17", "bib17" ]
12,601,084
NA|NA
Our data strongly suggest that transitions into the open state change intracellular access of ionized flecainide to the receptor site defined by residues on the S6 segments lining the inner pore, and like lidocaine, block by flecainide is stabilized by further transitions into the inactivated state (Liu et al., 2002).
[ "Liu et al., 2002", "Liu et al., 2002" ]
319
41,943
1
false
Our data strongly suggest that transitions into the open state change intracellular access of ionized flecainide to the receptor site defined by residues on the S6 segments lining the inner pore, and like lidocaine, block by flecainide is stabilized by further transitions into the inactivated state.
[ "Liu et al., 2002" ]
Our data strongly suggest that transitions into the open state change intracellular access of ionized flecainide to the receptor site defined by residues on the S6 segments lining the inner pore, and like lidocaine, block by flecainide is stabilized by further transitions into the inactivated state.
true
true
true
true
true
7,238
6
DISCUSSION
1
Hille, 1977a
[ "bib12", "bib14" ]
12,601,084
NA|NA
Interestingly, despite the apparent restricted access to inner pore receptor from closed, rested states, we find that channels blocked by charged flecainide (QX-FL) recover from channel block, albeit very slowly, at negative potentials even in the absence of channel openings (Fig.
[ "Hille, 1977a", "Hondeghem and Katzung, 1977" ]
281
41,944
0
false
Interestingly, despite the apparent restricted access to inner pore receptor from closed, rested states, we find that channels blocked by charged flecainide (QX-FL) recover from channel block, albeit very slowly, at negative potentials even in the absence of channel openings (Fig.
[]
Interestingly, despite the apparent restricted access to inner pore receptor from closed, rested states, we find that channels blocked by charged flecainide (QX-FL) recover from channel block, albeit very slowly, at negative potentials even in the absence of channel openings (Fig.
true
true
true
true
true
7,239
6
DISCUSSION
1
Hille, 1977a
[ "bib12", "bib14" ]
12,601,084
NA|NA
Thus there must be a pathway available for drug exit at rest.
[ "Hille, 1977a", "Hondeghem and Katzung, 1977" ]
61
41,945
0
false
Thus there must be a pathway available for drug exit at rest.
[]
Thus there must be a pathway available for drug exit at rest.
true
true
true
true
true
7,239
6
DISCUSSION
1
Hille, 1977a
[ "bib12", "bib14" ]
12,601,084
NA|NA
The facts that outer pore block by TTX slows the recovery of channels from QX-Fl block, even at voltages in which channels do not open, and that removal of extracellular Na+ has no effect on the recovery from channel block provide strong evidence that the drug can dissociate from channels at rest and diffuse slowly thr...
[ "Hille, 1977a", "Hondeghem and Katzung, 1977" ]
393
41,946
0
false
The facts that outer pore block by TTX slows the recovery of channels from QX-Fl block, even at voltages in which channels do not open, and that removal of extracellular Na+ has no effect on the recovery from channel block provide strong evidence that the drug can dissociate from channels at rest and diffuse slowly thr...
[]
The facts that outer pore block by TTX slows the recovery of channels from QX-Fl block, even at voltages in which channels do not open, and that removal of extracellular Na+ has no effect on the recovery from channel block provide strong evidence that the drug can dissociate from channels at rest and diffuse slowly thr...
true
true
true
true
true
7,239
6
DISCUSSION
1
Hille, 1977a
[ "bib12", "bib14" ]
12,601,084
NA|NA
Thus, in many ways the fundamental mechanisms of action of QX-FL and the charged lidocaine analogue QX-314 are very similar, indicating that it is the differences in distribution of charged and neutral forms of flecainide and lidocaine and not differences in chemical structures that accounts for the distinct voltage-de...
[ "Hille, 1977a", "Hondeghem and Katzung, 1977" ]
354
41,947
0
false
Thus, in many ways the fundamental mechanisms of action of QX-FL and the charged lidocaine analogue QX-314 are very similar, indicating that it is the differences in distribution of charged and neutral forms of flecainide and lidocaine and not differences in chemical structures that accounts for the distinct voltage-de...
[]
Thus, in many ways the fundamental mechanisms of action of QX-FL and the charged lidocaine analogue QX-314 are very similar, indicating that it is the differences in distribution of charged and neutral forms of flecainide and lidocaine and not differences in chemical structures that accounts for the distinct voltage-de...
true
true
true
true
true
7,239
6
DISCUSSION
1
Hille, 1977a
[ "bib12", "bib14" ]
12,601,084
NA|NA
As predicted by the modulated receptor hypothesis (Hille, 1977a; Hondeghem and Katzung, 1977), it thus appears that hydrophobic and hydrophilic access pathways to a common LA receptor in fact can explain the differences in activities of these two important drugs and must be addressed in considering novel analogues that...
[ "Hille, 1977a", "Hondeghem and Katzung, 1977" ]
492
41,948
0
false
As predicted by the modulated receptor hypothesis, it thus appears that hydrophobic and hydrophilic access pathways to a common LA receptor in fact can explain the differences in activities of these two important drugs and must be addressed in considering novel analogues that may be useful in the treatment of cardiac e...
[ "Hille, 1977a; Hondeghem and Katzung, 1977" ]
As predicted by the modulated receptor hypothesis, it thus appears that hydrophobic and hydrophilic access pathways to a common LA receptor in fact can explain the differences in activities of these two important drugs and must be addressed in considering novel analogues that may be useful in the treatment of cardiac e...
true
true
true
true
true
7,239
7
DISCUSSION
1
Liu et al., 2002
[ "bib17" ]
12,601,084
NA
That flecainde has proven to be particularly useful in the treatment of variant 3 of the long QT syndrome and as a diagnostic tool in identifying potential Brugada syndrome patients has raised the interest in understanding the mechanistic basis of mutation-altered interactions of the drug with cardiac Na+ channels.
[ "Liu et al., 2002" ]
316
41,949
0
false
That flecainde has proven to be particularly useful in the treatment of variant 3 of the long QT syndrome and as a diagnostic tool in identifying potential Brugada syndrome patients has raised the interest in understanding the mechanistic basis of mutation-altered interactions of the drug with cardiac Na+ channels.
[]
That flecainde has proven to be particularly useful in the treatment of variant 3 of the long QT syndrome and as a diagnostic tool in identifying potential Brugada syndrome patients has raised the interest in understanding the mechanistic basis of mutation-altered interactions of the drug with cardiac Na+ channels.
true
true
true
true
true
7,240
7
DISCUSSION
1
Liu et al., 2002
[ "bib17" ]
12,601,084
NA
Since the neutral components of lidocaine and flecainide, as evidenced by the data presented in this study, appear to interact with a common receptor and cause nearly identical changes in channel activity, it is most likely mutation-induced alteration in the access of the charged form of flecainide to a common LA recep...
[ "Liu et al., 2002" ]
392
41,950
0
false
Since the neutral components of lidocaine and flecainide, as evidenced by the data presented in this study, appear to interact with a common receptor and cause nearly identical changes in channel activity, it is most likely mutation-induced alteration in the access of the charged form of flecainide to a common LA recep...
[]
Since the neutral components of lidocaine and flecainide, as evidenced by the data presented in this study, appear to interact with a common receptor and cause nearly identical changes in channel activity, it is most likely mutation-induced alteration in the access of the charged form of flecainide to a common LA recep...
true
true
true
true
true
7,240
7
DISCUSSION
1
Liu et al., 2002
[ "bib17" ]
12,601,084
NA
Analysis of the effects of flecainide on disease-associated mutations that independently alter channel mean open time and/or the voltage dependence of channel availability has provided evidence in support of this view (Liu et al., 2002).
[ "Liu et al., 2002" ]
237
41,951
1
false
Analysis of the effects of flecainide on disease-associated mutations that independently alter channel mean open time and/or the voltage dependence of channel availability has provided evidence in support of this view.
[ "Liu et al., 2002" ]
Analysis of the effects of flecainide on disease-associated mutations that independently alter channel mean open time and/or the voltage dependence of channel availability has provided evidence in support of this view.
true
true
true
true
true
7,240
0
INTRODUCTION
1
Beuchat & Rice 1979
[ "R5", "R48", "R54", "R49", "R42", "R44" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
Byssochlamys species produce ascospores which are heat-resistant, and survive considerable periods of heat above 85 °C (Beuchat & Rice 1979, Splittstoesser 1987).
[ "Beuchat & Rice 1979", "Splittstoesser 1987", "Taniwaki 1995", "Stolk & Samson (1971)", "Samson (1974)", "Samson & Tansey 1975" ]
167
41,952
0
false
Byssochlamys species produce ascospores which are heat-resistant, and survive considerable periods of heat above 85 °C.
[ "Beuchat & Rice 1979, Splittstoesser 1987" ]
Byssochlamys species produce ascospores which are heat-resistant, and survive considerable periods of heat above 85 °C.
true
true
true
true
true
7,241
0
INTRODUCTION
1
Taniwaki 1995
[ "R5", "R48", "R54", "R49", "R42", "R44" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
In addition to their heat resistance, Byssochlamys species can grow under very low oxygen tensions (Taniwaki 1995) and can form pectinolytic enzymes.
[ "Beuchat & Rice 1979", "Splittstoesser 1987", "Taniwaki 1995", "Stolk & Samson (1971)", "Samson (1974)", "Samson & Tansey 1975" ]
149
41,953
1
false
In addition to their heat resistance, Byssochlamys species can grow under very low oxygen tensions and can form pectinolytic enzymes.
[ "Taniwaki 1995" ]
In addition to their heat resistance, Byssochlamys species can grow under very low oxygen tensions and can form pectinolytic enzymes.
true
true
true
true
true
7,241
0
INTRODUCTION
1
Beuchat & Rice 1979
[ "R5", "R48", "R54", "R49", "R42", "R44" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
The combination of these three physiological characteristics makes Byssochlamys species very important spoilage fungi in pasteurised and canned fruit.
[ "Beuchat & Rice 1979", "Splittstoesser 1987", "Taniwaki 1995", "Stolk & Samson (1971)", "Samson (1974)", "Samson & Tansey 1975" ]
150
41,954
0
false
The combination of these three physiological characteristics makes Byssochlamys species very important spoilage fungi in pasteurised and canned fruit.
[]
The combination of these three physiological characteristics makes Byssochlamys species very important spoilage fungi in pasteurised and canned fruit.
true
true
true
true
true
7,241
0
INTRODUCTION
1
Beuchat & Rice 1979
[ "R5", "R48", "R54", "R49", "R42", "R44" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
Byssochlamys has a Paecilomyces anamorph and the genus was revised by Stolk & Samson (1971).
[ "Beuchat & Rice 1979", "Splittstoesser 1987", "Taniwaki 1995", "Stolk & Samson (1971)", "Samson (1974)", "Samson & Tansey 1975" ]
92
41,955
0
false
Byssochlamys has a Paecilomyces anamorph and the genus was revised by Stolk & Samson (1971).
[]
Byssochlamys has a Paecilomyces anamorph and the genus was revised by Stolk & Samson.
true
true
true
true
true
7,241
0
INTRODUCTION
1
Beuchat & Rice 1979
[ "R5", "R48", "R54", "R49", "R42", "R44" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
Samson (1974) accepted three Byssochlamys species: B. fulva, B. nivea and B. zollerniae with similar Paecilomyces anamorphs.
[ "Beuchat & Rice 1979", "Splittstoesser 1987", "Taniwaki 1995", "Stolk & Samson (1971)", "Samson (1974)", "Samson & Tansey 1975" ]
124
41,956
0
false
Samson (1974) accepted three Byssochlamys species: B. fulva, B. nivea and B. zollerniae with similar Paecilomyces anamorphs.
[]
Samson accepted three Byssochlamys species: B. fulva, B. nivea and B. zollerniae with similar Paecilomyces anamorphs.
true
true
true
true
true
7,241
0
INTRODUCTION
1
Samson & Tansey 1975
[ "R5", "R48", "R54", "R49", "R42", "R44" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
Since then only B. verrucosa has been added to this genus (Samson & Tansey 1975).
[ "Beuchat & Rice 1979", "Splittstoesser 1987", "Taniwaki 1995", "Stolk & Samson (1971)", "Samson (1974)", "Samson & Tansey 1975" ]
81
41,957
1
false
Since then only B. verrucosa has been added to this genus.
[ "Samson & Tansey 1975" ]
Since then only B. verrucosa has been added to this genus.
true
true
true
true
true
7,241
1
INTRODUCTION
1
Bainier (1907)
[ "R3", "R6", "R42", "R31", "R56", "R42" ]
20,198,134
NA|NA|NA|NA|NA|NA
Paecilomyces was erected by Bainier (1907) to accommodate a single species, P. variotii, but many species were added (Brown & Smith 1957, Samson 1974).
[ "Bainier (1907)", "Brown & Smith 1957", "Samson 1974", "Luangsa-ard et al. (2004)", "Thom (1930)", "Samson (1974)" ]
156
41,958
0
false
Paecilomyces was erected by Bainier (1907) to accommodate a single species, P. variotii, but many species were added.
[ "Brown & Smith 1957, Samson 1974" ]
Paecilomyces was erected by Bainier to accommodate a single species, P. variotii, but many species were added.
true
true
true
true
true
7,242
1
INTRODUCTION
1
Bainier (1907)
[ "R3", "R6", "R42", "R31", "R56", "R42" ]
20,198,134
NA|NA|NA|NA|NA|NA
Luangsa-ard et al.
[ "Bainier (1907)", "Brown & Smith 1957", "Samson 1974", "Luangsa-ard et al. (2004)", "Thom (1930)", "Samson (1974)" ]
18
41,959
0
false
Luangsa-ard et al.
[]
Luangsa-ard et al.
true
true
true
true
true
7,242
1
INTRODUCTION
1
Bainier (1907)
[ "R3", "R6", "R42", "R31", "R56", "R42" ]
20,198,134
NA|NA|NA|NA|NA|NA
(2004) presented a phylogenetic analysis of the 18S rDNA, demonstrating that Paecilomyces is polyphyletic across the Sordariomycetidae and Eurotiomycetidae.
[ "Bainier (1907)", "Brown & Smith 1957", "Samson 1974", "Luangsa-ard et al. (2004)", "Thom (1930)", "Samson (1974)" ]
156
41,960
0
false
(2004) presented a phylogenetic analysis of the 18S rDNA, demonstrating that Paecilomyces is polyphyletic across the Sordariomycetidae and Eurotiomycetidae.
[]
presented a phylogenetic analysis of the 18S rDNA, demonstrating that Paecilomyces is polyphyletic across the Sordariomycetidae and Eurotiomycetidae.
false
true
true
true
false
7,242
1
INTRODUCTION
1
Bainier (1907)
[ "R3", "R6", "R42", "R31", "R56", "R42" ]
20,198,134
NA|NA|NA|NA|NA|NA
The type species P. variotii is a morphologically variable taxon, and has been redescribed under a variety of names broadening its circumscription.
[ "Bainier (1907)", "Brown & Smith 1957", "Samson 1974", "Luangsa-ard et al. (2004)", "Thom (1930)", "Samson (1974)" ]
147
41,961
0
false
The type species P. variotii is a morphologically variable taxon, and has been redescribed under a variety of names broadening its circumscription.
[]
The type species P. variotii is a morphologically variable taxon, and has been redescribed under a variety of names broadening its circumscription.
true
true
true
true
true
7,242
1
INTRODUCTION
1
Bainier (1907)
[ "R3", "R6", "R42", "R31", "R56", "R42" ]
20,198,134
NA|NA|NA|NA|NA|NA
Thom (1930) and Samson (1974) mentioned the diversity in conidial shape and size, and Thom made a tentative division based on conidial size.
[ "Bainier (1907)", "Brown & Smith 1957", "Samson 1974", "Luangsa-ard et al. (2004)", "Thom (1930)", "Samson (1974)" ]
140
41,962
0
false
Thom (1930) and Samson (1974) mentioned the diversity in conidial shape and size, and Thom made a tentative division based on conidial size.
[]
Thom and Samson mentioned the diversity in conidial shape and size, and Thom made a tentative division based on conidial size.
true
true
true
true
true
7,242
2
INTRODUCTION
1
Houbraken et al. (2006)
[ "R21" ]
20,198,134
NA|NA|NA|NA|NA
Paecilomyces variotii and anamorphs of Byssochlamys species share several micromorphological characters, including phialides with cylindrical bases that taper abruptly into long cylindrical necks and produce catenate conidia.
[ "Houbraken et al. (2006)" ]
230
41,963
0
false
Paecilomyces variotii and anamorphs of Byssochlamys species share several micromorphological characters, including phialides with cylindrical bases that taper abruptly into long cylindrical necks and produce catenate conidia.
[]
Paecilomyces variotii and anamorphs of Byssochlamys species share several micromorphological characters, including phialides with cylindrical bases that taper abruptly into long cylindrical necks and produce catenate conidia.
true
true
true
true
true
7,243
2
INTRODUCTION
1
Houbraken et al. (2006)
[ "R21" ]
20,198,134
NA|NA|NA|NA|NA
Some characters are constant at the species level, but vary among species.
[ "Houbraken et al. (2006)" ]
74
41,964
0
false
Some characters are constant at the species level, but vary among species.
[]
Some characters are constant at the species level, but vary among species.
true
true
true
true
true
7,243
2
INTRODUCTION
1
Houbraken et al. (2006)
[ "R21" ]
20,198,134
NA|NA|NA|NA|NA
Houbraken et al.
[ "Houbraken et al. (2006)" ]
16
41,965
0
false
Houbraken et al.
[]
Houbraken et al.
true
true
true
true
true
7,243
2
INTRODUCTION
1
Houbraken et al. (2006)
[ "R21" ]
20,198,134
NA|NA|NA|NA|NA
(2006) demonstrated that Byssochlamys and its associated anamorph species can be separated into at least nine taxa by investigating the micro- and macroscopical characteristics of Byssochlamys and Paecilomyces variotii-like isolates.
[ "Houbraken et al. (2006)" ]
233
41,966
0
false
(2006) demonstrated that Byssochlamys and its associated anamorph species can be separated into at least nine taxa by investigating the micro- and macroscopical characteristics of Byssochlamys and Paecilomyces variotii-like isolates.
[]
demonstrated that Byssochlamys and its associated anamorph species can be separated into at least nine taxa by investigating the micro- and macroscopical characteristics of Byssochlamys and Paecilomyces variotii-like isolates.
false
true
true
true
false
7,243
2
INTRODUCTION
1
Houbraken et al. (2006)
[ "R21" ]
20,198,134
NA|NA|NA|NA|NA
In this study, we have extended this to a polyphasic approach by adding molecular and extrolite data and present a revised taxonomy and nomenclature of the accepted taxa.
[ "Houbraken et al. (2006)" ]
170
41,967
0
false
In this study, we have extended this to a polyphasic approach by adding molecular and extrolite data and present a revised taxonomy and nomenclature of the accepted taxa.
[]
In this study, we have extended this to a polyphasic approach by adding molecular and extrolite data and present a revised taxonomy and nomenclature of the accepted taxa.
true
true
true
true
true
7,243
0
DISCUSSION
1
Samson (1974)
[ "R42", "R31" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
Byssochlamys isolates were included in this study to verify the connection between the anamorphic P. variotii complex and holomorphic Byssochlamys species.
[ "Samson (1974)", "Luangsa-ard et al. 2004" ]
160
41,968
0
false
Byssochlamys isolates were included in this study to verify the connection between the anamorphic P. variotii complex and holomorphic Byssochlamys species.
[]
Byssochlamys isolates were included in this study to verify the connection between the anamorphic P. variotii complex and holomorphic Byssochlamys species.
true
true
true
true
true
7,244
0
DISCUSSION
1
Samson (1974)
[ "R42", "R31" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
The genus Paecilomyces was monographed by Samson (1974) who recognised 31 species divided into two sections, Paecilomyces and Isarioidea.
[ "Samson (1974)", "Luangsa-ard et al. 2004" ]
137
41,969
0
false
The genus Paecilomyces was monographed by Samson (1974) who recognised 31 species divided into two sections, Paecilomyces and Isarioidea.
[]
The genus Paecilomyces was monographed by Samson who recognised 31 species divided into two sections, Paecilomyces and Isarioidea.
true
true
true
true
true
7,244
0
DISCUSSION
1
Samson (1974)
[ "R42", "R31" ]
20,198,134
NA|NA|NA|NA|NA|NA|NA|NA
However, the phylogenetic analysis of the 18S rDNA demonstrates that Paecilomyces is polyphyletic across two subclasses, Sordariomycetidae and Eurotiomycetidae (Luangsa-ard et al.
[ "Samson (1974)", "Luangsa-ard et al. 2004" ]
179
41,970
0
false
However, the phylogenetic analysis of the 18S rDNA demonstrates that Paecilomyces is polyphyletic across two subclasses, Sordariomycetidae and Eurotiomycetidae (Luangsa-ard et al.
[]
However, the phylogenetic analysis of the 18S rDNA demonstrates that Paecilomyces is polyphyletic across two subclasses, Sordariomycetidae and Eurotiomycetidae (Luangsa-ard et al.
true
true
true
true
true
7,244
1
DISCUSSION
0
null
null
20,198,134
NA|NA|NA|NA|NA|NA
Therefore, Paecilomyces is only monophyletic within the order Eurotiales and characterised by a Byssochlamys teleomorph.
null
120
41,971
0
false
null
null
Therefore, Paecilomyces is only monophyletic within the order Eurotiales and characterised by a Byssochlamys teleomorph.
true
true
true
true
true
7,245
1
DISCUSSION
0
null
null
20,198,134
NA|NA|NA|NA|NA|NA
In the present study the P. variotii complex could be divided into four species, P. divaricatus, P. formosus, P. saturatus and P. variotii.
null
139
41,972
0
false
null
null
In the present study the P. variotii complex could be divided into four species, P. divaricatus, P. formosus, P. saturatus and P. variotii.
true
true
true
true
true
7,245
2
DISCUSSION
1
Udagawa & Suzuki (1994)
[ "R58", "R31", "R22", "R36" ]
20,198,134
NA|NA|NA|NA|NA
Udagawa & Suzuki (1994) described Talaromyces spectabilis, but phylogenetic analysis of the 18S rDNA clarified that this species belongs to the genus Byssochlamys (Luangsa-ard et al.
[ "Udagawa & Suzuki (1994)", "Luangsa-ard et al. 2004", "Houbraken et al. (2008)", "Piecková & Samson 2000" ]
187
41,973
0
false
Udagawa & Suzuki (1994) described Talaromyces spectabilis, but phylogenetic analysis of the 18S rDNA clarified that this species belongs to the genus Byssochlamys (Luangsa-ard et al.
[]
Udagawa & Suzuki described Talaromyces spectabilis, but phylogenetic analysis of the 18S rDNA clarified that this species belongs to the genus Byssochlamys (Luangsa-ard et al.
true
true
true
true
true
7,246
2
DISCUSSION
1
Udagawa & Suzuki (1994)
[ "R58", "R31", "R22", "R36" ]
20,198,134
NA|NA|NA|NA|NA
Recently, Houbraken et al.
[ "Udagawa & Suzuki (1994)", "Luangsa-ard et al. 2004", "Houbraken et al. (2008)", "Piecková & Samson 2000" ]
26
41,974
0
false
Recently, Houbraken et al.
[]
Recently, Houbraken et al.
true
true
true
true
true
7,246
2
DISCUSSION
1
Udagawa & Suzuki (1994)
[ "R58", "R31", "R22", "R36" ]
20,198,134
NA|NA|NA|NA|NA
(2008) showed that this species is heterothallic and that it is linked to the anamorphic species P. variotii.
[ "Udagawa & Suzuki (1994)", "Luangsa-ard et al. 2004", "Houbraken et al. (2008)", "Piecková & Samson 2000" ]
109
41,975
0
false
(2008) showed that this species is heterothallic and that it is linked to the anamorphic species P. variotii.
[]
(2008) showed that this species is heterothallic and that it is linked to the anamorphic species P. variotii.
false
false
true
true
false
7,246
2
DISCUSSION
1
Udagawa & Suzuki (1994)
[ "R58", "R31", "R22", "R36" ]
20,198,134
NA|NA|NA|NA|NA
This was confirmed in the present study by morphological features and extrolite data.
[ "Udagawa & Suzuki (1994)", "Luangsa-ard et al. 2004", "Houbraken et al. (2008)", "Piecková & Samson 2000" ]
85
41,976
0
false
This was confirmed in the present study by morphological features and extrolite data.
[]
This was confirmed in the present study by morphological features and extrolite data.
true
true
true
true
true
7,246
2
DISCUSSION
1
Piecková & Samson 2000
[ "R58", "R31", "R22", "R36" ]
20,198,134
NA|NA|NA|NA|NA
The presence of a teleomorph with heat-resistant ascospores for P. variotii explains the ability of this fungus to spoil heat treated fruit juices (Piecková & Samson 2000).
[ "Udagawa & Suzuki (1994)", "Luangsa-ard et al. 2004", "Houbraken et al. (2008)", "Piecková & Samson 2000" ]
172
41,977
1
false
The presence of a teleomorph with heat-resistant ascospores for P. variotii explains the ability of this fungus to spoil heat treated fruit juices.
[ "Piecková & Samson 2000" ]
The presence of a teleomorph with heat-resistant ascospores for P. variotii explains the ability of this fungus to spoil heat treated fruit juices.
true
true
true
true
true
7,246
3
DISCUSSION
1
Stolk & Samson (1971)
[ "R49", "R44" ]
20,198,134
NA|NA
Short descriptions of B. lagunculariae, B. spectabilis, P. brunneolus, P. divaricatus, P. formosus and P. saturatus are presented.
[ "Stolk & Samson (1971)", "Samson & Tansey (1975)" ]
130
41,978
0
false
Short descriptions of B. lagunculariae, B. spectabilis, P. brunneolus, P. divaricatus, P. formosus and P. saturatus are presented.
[]
Short descriptions of B. lagunculariae, B. spectabilis, P. brunneolus, P. divaricatus, P. formosus and P. saturatus are presented.
true
true
true
true
true
7,247
3
DISCUSSION
1
Stolk & Samson (1971)
[ "R49", "R44" ]
20,198,134
NA|NA
The concepts of B. fulva, B. nivea and B. zollerniae are unchanged since the descriptions by Stolk & Samson (1971), with the remark that B. nivea var.
[ "Stolk & Samson (1971)", "Samson & Tansey (1975)" ]
150
41,979
0
false
The concepts of B. fulva, B. nivea and B. zollerniae are unchanged since the descriptions by Stolk & Samson (1971), with the remark that B. nivea var.
[]
The concepts of B. fulva, B. nivea and B. zollerniae are unchanged since the descriptions by Stolk & Samson, with the remark that B. nivea var.
true
true
true
true
true
7,247
3
DISCUSSION
1
Stolk & Samson (1971)
[ "R49", "R44" ]
20,198,134
NA|NA
langunculariae is elevated to species level.
[ "Stolk & Samson (1971)", "Samson & Tansey (1975)" ]
44
41,980
0
false
langunculariae is elevated to species level.
[]
langunculariae is elevated to species level.
false
true
true
true
false
7,247
3
DISCUSSION
1
Stolk & Samson (1971)
[ "R49", "R44" ]
20,198,134
NA|NA
Byssochlamys verrucosa is not discussed here, because the taxon probably belongs to Thermoascus; it was fully described by Samson & Tansey (1975).
[ "Stolk & Samson (1971)", "Samson & Tansey (1975)" ]
146
41,981
0
false
Byssochlamys verrucosa is not discussed here, because the taxon probably belongs to Thermoascus; it was fully described by Samson & Tansey (1975).
[]
Byssochlamys verrucosa is not discussed here, because the taxon probably belongs to Thermoascus; it was fully described by Samson & Tansey.
true
true
true
true
true
7,247
3
DISCUSSION
1
Stolk & Samson (1971)
[ "R49", "R44" ]
20,198,134
NA|NA
Microscopic dimensions and cultural characters are summarised in Table 3.
[ "Stolk & Samson (1971)", "Samson & Tansey (1975)" ]
73
41,982
0
false
Microscopic dimensions and cultural characters are summarised in Table 3.
[]
Microscopic dimensions and cultural characters are summarised in Table 3.
true
true
true
true
true
7,247
4
DISCUSSION
0
null
null
20,198,134
null
Byssochlamys lagunculariae (C. Ram) Samson, Houbraken & Frisvad, comb.
null
76
41,983
0
false
null
null
Byssochlamys lagunculariae (C. Ram) Samson, Houbraken & Frisvad, comb.
false
false
true
true
false
7,248
4
DISCUSSION
0
null
null
20,198,134
null
nov. — MycoBank MB512557; Fig.
null
30
41,984
0
false
null
null
nov. — MycoBank MB512557; Fig.
false
true
true
true
false
7,248
5
DISCUSSION
0
null
null
20,198,134
null
Basionym.
null
15
41,985
0
false
null
null
Basionym.
false
false
true
true
false
7,249
5
DISCUSSION
0
null
null
20,198,134
null
Byssochlamys nivea Westling var.
null
32
41,986
0
false
null
null
Byssochlamys nivea Westling var.
true
true
true
true
true
7,249
5
DISCUSSION
0
null
null
20,198,134
null
lagunculariae C. Ram, Nova Hedwigia 16: 311.
null
44
41,987
0
false
null
null
lagunculariae C. Ram, Nova Hedwigia 16: 311.
false
true
true
true
false
7,249
6
DISCUSSION
0
null
null
20,198,134
null
Byssochlamys lagunculariae strains grow fast on MEA, covering the dish within 7 d at 30 °C.
null
97
41,988
0
false
null
null
Byssochlamys lagunculariae strains grow fast on MEA, covering the dish within 7 d at 30 °C.
false
false
true
true
false
7,250
6
DISCUSSION
0
null
null
20,198,134
null
Depending on the isolate, it predominantly forms conidia (CBS 373.70T) or ascomata (CBS 696.95).
null
96
41,989
0
false
null
null
Depending on the isolate, it predominantly forms conidia (CBS 373.70T) or ascomata (CBS 696.95).
true
true
true
true
true
7,250
6
DISCUSSION
0
null
null
20,198,134
null
Colonies 25–55 mm on MEA at 37 °C after 7 d of incubation.
null
58
41,990
0
false
null
null
Colonies 25–55 mm on MEA at 37 °C after 7 d of incubation.
true
true
true
true
true
7,250
6
DISCUSSION
0
null
null
20,198,134
null
Growth occurs under microaerophilic conditions, in the presence of 0.5 % acetic acid or 1 000 ppm propionic acid (pH 3.8).
null
122
41,991
0
false
null
null
Growth occurs under microaerophilic conditions, in the presence of 0.5 % acetic acid or 1 000 ppm propionic acid (pH 3.8).
true
true
true
true
true
7,250
6
DISCUSSION
0
null
null
20,198,134
null
No growth is observed on CYA with 5 % NaCl.
null
43
41,992
0
false
null
null
No growth is observed on CYA with 5 % NaCl.
true
true
true
true
true
7,250
6
DISCUSSION
0
null
null
20,198,134
null
Poor growth and no acid production on CREA.
null
43
41,993
0
false
null
null
Poor growth and no acid production on CREA.
true
true
true
true
true
7,250
7
DISCUSSION
0
null
null
20,198,134
null
Morphologically, B. lagunculariae is similar to B. nivea and shares various characters such as fast growth rate on MEA at 30 °C and globose (to ellipsoidal) conidia with a flattened base.
null
187
41,994
0
false
null
null
Morphologically, B. lagunculariae is similar to B. nivea and shares various characters such as fast growth rate on MEA at 30 °C and globose (to ellipsoidal) conidia with a flattened base.
true
true
true
true
true
7,251
7
DISCUSSION
0
null
null
20,198,134
null
Chlamydospores are present, uncoloured and smooth-walled.
null
57
41,995
0
false
null
null
Chlamydospores are present, uncoloured and smooth-walled.
true
true
true
true
true
7,251
7
DISCUSSION
0
null
null
20,198,134
null
Though similar in shape to those of B. nivea, the conidia and ascospores of B. lagunculariae are generally smaller in size.
null
123
41,996
0
false
null
null
Though similar in shape to those of B. nivea, the conidia and ascospores of B. lagunculariae are generally smaller in size.
true
true
true
true
true
7,251
7
DISCUSSION
0
null
null
20,198,134
null
Another difference is that B. lagunculariae grows well on CYA while B. nivea grows rather poorly.
null
97
41,997
0
false
null
null
Another difference is that B. lagunculariae grows well on CYA while B. nivea grows rather poorly.
true
true
true
true
true
7,251
8
DISCUSSION
1
Ram (1968)
[ "R38", "R49" ]
20,198,134
NA|NA
Our molecular studies and morphological examinations both revealed that B. lagunculariae is clearly distinct from B. nivea.
[ "Ram (1968)", "Stolk & Samson (1971)" ]
123
41,998
0
false
Our molecular studies and morphological examinations both revealed that B. lagunculariae is clearly distinct from B. nivea.
[]
Our molecular studies and morphological examinations both revealed that B. lagunculariae is clearly distinct from B. nivea.
true
true
true
true
true
7,252
8
DISCUSSION
1
Ram (1968)
[ "R38", "R49" ]
20,198,134
NA|NA
In the original description by Ram (1968), B. lagunculariae was described as a variety of B. nivea, distinguished by its smaller conidia and ascospores.
[ "Ram (1968)", "Stolk & Samson (1971)" ]
152
41,999
0
false
In the original description by Ram (1968), B. lagunculariae was described as a variety of B. nivea, distinguished by its smaller conidia and ascospores.
[]
In the original description by Ram, B. lagunculariae was described as a variety of B. nivea, distinguished by its smaller conidia and ascospores.
true
true
true
true
true
7,252
8
DISCUSSION
1
Ram (1968)
[ "R38", "R49" ]
20,198,134
NA|NA
Stolk & Samson (1971) synonymised it with B. nivea, but the present study showed that the growth rate on CYA, and smaller conidial and ascospore sizes are constant characters that can be used to differentiate between these species.
[ "Ram (1968)", "Stolk & Samson (1971)" ]
231
42,000
0
false
Stolk & Samson (1971) synonymised it with B. nivea, but the present study showed that the growth rate on CYA, and smaller conidial and ascospore sizes are constant characters that can be used to differentiate between these species.
[]
Stolk & Samson synonymised it with B. nivea, but the present study showed that the growth rate on CYA, and smaller conidial and ascospore sizes are constant characters that can be used to differentiate between these species.
true
true
true
true
true
7,252
9
DISCUSSION
0
null
null
20,198,134
null
This species produces a similar range of extrolites to B. nivea, but patulin has not been detected in B. lagunculariae.
null
119
42,001
0
false
null
null
This species produces a similar range of extrolites to B. nivea, but patulin has not been detected in B. lagunculariae.
true
true
true
true
true
7,253
9
DISCUSSION
0
null
null
20,198,134
null
Differentiation between B. nivea and B. lagunculariae, based on extrolite profiles, is not possible.
null
100
42,002
0
false
null
null
Differentiation between B. nivea and B. lagunculariae, based on extrolite profiles, is not possible.
true
true
true
true
true
7,253
10
DISCUSSION
0
null
null
20,198,134
null
The ex-type culture was isolated from wood of Laguncularia racemosa (mangue) in Brazil and other strains identified as this species were found in soil, and pasteurised strawberries and aloe juice.
null
196
42,003
0
false
null
null
The ex-type culture was isolated from wood of Laguncularia racemosa (mangue) in Brazil and other strains identified as this species were found in soil, and pasteurised strawberries and aloe juice.
true
true
true
true
true
7,254
10
DISCUSSION
0
null
null
20,198,134
null
The occurrence of this species in heat treated products makes it an important food spoilage organism.
null
101
42,004
0
false
null
null
The occurrence of this species in heat treated products makes it an important food spoilage organism.
true
true
true
true
true
7,254
11
DISCUSSION
0
null
null
20,198,134
null
Byssochlamys spectabilis (Udagawa & Shoji Suzuki) Houbraken & Samson, Appl.
null
81
42,005
0
false
null
null
Byssochlamys spectabilis (Udagawa & Shoji Suzuki) Houbraken & Samson, Appl.
false
false
true
true
false
7,255
12
DISCUSSION
0
null
null
20,198,134
null
Basionym.
null
15
42,006
0
false
null
null
Basionym.
false
false
true
true
false
7,256
12
DISCUSSION
0
null
null
20,198,134
null
Talaromyces spectabilis Udagawa & Shoji Suzuki, Mycotaxon 50: 82.
null
65
42,007
0
false
null
null
Talaromyces spectabilis Udagawa & Shoji Suzuki, Mycotaxon 50: 82.
true
true
true
true
true
7,256
13
DISCUSSION
0
null
null
20,198,134
null
Anamorph.
null
15
42,008
0
false
null
null
Anamorph.
false
false
true
true
false
7,257
13
DISCUSSION
0
null
null
20,198,134
null
Paecilomyces variotii Bainier, Bull.
null
36
42,009
0
false
null
null
Paecilomyces variotii Bainier, Bull.
true
true
true
true
true
7,257
13
DISCUSSION
0
null
null
20,198,134
null
Trimestriel Soc.
null
16
42,010
0
false
null
null
Trimestriel Soc.
true
true
true
true
true
7,257
13
DISCUSSION
0
null
null
20,198,134
null
France 23: 26.
null
14
42,011
0
false
null
null
France 23: 26.
true
true
true
true
true
7,257
14
DISCUSSION
0
null
null
20,198,134
null
≡ Penicillium variotii (Bainier)
null
32
42,012
0
false
null
null
≡ Penicillium variotii (Bainier)
false
false
false
true
false
7,258
14
DISCUSSION
0
null
null
20,198,134
null
Sacc., Syll.
null
12
42,013
0
false
null
null
Sacc., Syll.
true
true
true
true
true
7,258
15
DISCUSSION
1
Houbraken et al. 2008
[ "R22" ]
20,198,134
NA
Colonies spreading rapidly on MEA at 30 °C and covering the Petri dish within 7 d. Similar or higher growth rate at 37 °C than at 30 °C.
[ "Houbraken et al. 2008" ]
136
42,014
0
false
Colonies spreading rapidly on MEA at 30 °C and covering the Petri dish within 7 d. Similar or higher growth rate at 37 °C than at 30 °C.
[]
Colonies spreading rapidly on MEA at 30 °C and covering the Petri dish within 7 d. Similar or higher growth rate at 37 °C than at 30 °C.
true
true
true
true
true
7,259
15
DISCUSSION
1
Houbraken et al. 2008
[ "R22" ]
20,198,134
NA
Good growth under microaerophilic conditions, on MEA with 0.5 % acetic acid and on CYA with 1 000 ppm propionic acid (pH 3.8).
[ "Houbraken et al. 2008" ]
126
42,015
0
false
Good growth under microaerophilic conditions, on MEA with 0.5 % acetic acid and on CYA with 1 000 ppm propionic acid (pH 3.8).
[]
Good growth under microaerophilic conditions, on MEA with 0.5 % acetic acid and on CYA with 1 000 ppm propionic acid.
true
true
true
true
true
7,259
15
DISCUSSION
1
Houbraken et al. 2008
[ "R22" ]
20,198,134
NA
No or weak growth on CYA with 5 % NaCl (0–10 mm).
[ "Houbraken et al. 2008" ]
49
42,016
0
false
No or weak growth on CYA with 5 % NaCl (0–10 mm).
[]
No or weak growth on CYA with 5 % NaCl.
true
true
true
true
true
7,259
15
DISCUSSION
1
Houbraken et al. 2008
[ "R22" ]
20,198,134
NA
Since B. spectabilis forms its ascospores in a heterothallic manner, only the anamorph is usually produced.
[ "Houbraken et al. 2008" ]
107
42,017
0
false
Since B. spectabilis forms its ascospores in a heterothallic manner, only the anamorph is usually produced.
[]
Since B. spectabilis forms its ascospores in a heterothallic manner, only the anamorph is usually produced.
true
true
true
true
true
7,259
15
DISCUSSION
1
Houbraken et al. 2008
[ "R22" ]
20,198,134
NA
The conidiophores are irregularly branched and ellipsoidal and/or cylindrical; truncate conidia are formed, which are often pale yellow brown.
[ "Houbraken et al. 2008" ]
142
42,018
0
false
The conidiophores are irregularly branched and ellipsoidal and/or cylindrical; truncate conidia are formed, which are often pale yellow brown.
[]
The conidiophores are irregularly branched and ellipsoidal and/or cylindrical; truncate conidia are formed, which are often pale yellow brown.
true
true
true
true
true
7,259