instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: atp synthase f1 subunit alpha pseudogene 1 (homo sapiens) (aka atp synthase f1 subunit alpha pseudogene 1)
B: atp1a1os (homo sapiens) (aka atp1a1 antisense rna 1)
C: atp1a3 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 3)
D: cd2 locus control region (... | [E; O; U; M] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: cd22 (homo sapiens) (aka cd22 molecule)
B: cd11a (homo sapiens) (aka integrin subunit alpha l)
C: atpase na+/k+ transporting subunit alpha 1 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 1)
D: leu-3 (homo sapiens) (aka cd4 molecule)
E: atp8a1 (homo sa... | [K; S; U; C] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
B: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
C: bcsc-1 (homo sapiens) (aka von willebrand factor a domain containing 5a)
D: mbc1 (homo sapiens) (aka coiled-coil d... | [O; H; F; L] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: atp2a1 (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1)
B: bcsc-1 (homo sapiens) (aka von willebrand factor a domain containing 5a)
C: bcrm1 (homo sapiens) (aka sideroflexin 4)
D: atp2a2 (homo sapiens) (aka atpase sarcoplasmic/end... | [Q; G; I; L] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: atp3 (saccharomyces cerevisiae s288c) (aka f1f0 atp synthase subunit ga... | [A; O; E; G] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: atp1al2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 4)
B: atp6a2 (homo sapiens) (aka atpase h+ transporting v0 subunit a2)
C: atppa3 (arabidopsis thaliana) (aka pyrophosphorylase 3)
D: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
E:... | [K; J; P; M] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
C: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
D: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
E: bcrm1 (homo sapiens) (aka sideroflexin 4)
F: bcm1... | [F; N; L] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
B: cd22 molecule (homo sapiens) (aka cd22 molecule)
C: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
D: cd2 molecule (bos taurus) (aka cd2 molecule)
E: lfa-1 (homo sapiens) (integrin subunit beta 2 (ho... | [N; J; H] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
B: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
C: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
D: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
E: cd2 molecule (homo sapiens) (aka cd2 molecule)
F... | [L; E; F] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: lfa1a (homo sapiens) (aka integrin subunit alpha l)
C: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
D: bcrm1 (homo sapiens) (aka sideroflexin 4)
E: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
F: cd22 molecule (homo... | [L; H; O] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd22 molecule (homo sapiens) (aka cd22 molecule)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: leu-3 (homo sapiens) (aka cd4 molecule)
D: cd2 (gallus gallus) (aka cd2 molecule)
E: cd2 (homo sapiens) (aka cd2 molecule)
F: lfa-1 (homo sapiens) (in... | [E; L; N] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
D: leu-3 (homo sapiens) (aka cd4 molecule)
E: lfa3 (homo sapiens) (aka cd58 molecule)
F: bcm1 (homo sapiens) (aka cd4... | [M; E; F] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
B: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
C: lfa3 (homo sapiens) (aka cd58 molecule)
D: lfa-2 (homo sapiens) (aka cd2 molecule)
E: bcm (homo sapi... | [Q; C; K; I] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: leu-3 (homo sapiens) (aka cd4 molecule)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
D: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
E: cd2 locus control regio... | [L; I; O; H] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: mbt-1 (homo sapiens) (aka l3mbtl histone methyl-lysine binding protein 3)
B: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
C: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
D: cd22 molecule (homo sapiens) (aka cd22 molecule)
E: bcsc-1 (homo sapiens)... | [Q; H; J; P] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: mbt-1 (homo sapiens) (aka l3mbtl histone methyl-lysine binding protein 3)
B: cd2 molecule (homo sapiens) (aka cd2 molecule)
C: bcrm1 (homo sapiens) (aka sideroflexin 4)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: bcmo1 (homo sapiens) (a... | [B; J; K; F] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [bcm1]
<Options>: A: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
B: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: bcm1 (homo sapiens) (aka cd48 molecule)
D: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
E: bcmo1 (homo sapiens) (aka beta-c... | [C] |
<Instruct>: Given the context 'The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [type i tnf-r]
<Options>: A: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
B: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
D: None of the above. | [B] |
<Instruct>: Given the context 'Two proteins which specifically bind tumor necrosis factor (TNF) have recently been isolated from human urine in our laboratory.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [tumor necrosis factor; tnf]
<Options>: A: tnfb (homo sapiens) (aka lymphotoxin alpha)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tumor necrosis factor (oryctolagus cun... | [G; G] |
<Instruct>: Given the context 'Two proteins which specifically bind tumor necrosis factor (TNF) have recently been isolated from human urine in our laboratory.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [tumor necrosis factor; tnf]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
D: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
E: tnf superfamily mem... | [D; D] |
<Instruct>: Given the context 'Antibodies against one of the two TNF binding proteins (TBPI) were found to have effects characteristic of TNF, including stimulating phosphorylation of specific cellular proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [tnf]
<Options>: A: tnf (homo sapiens) (aka tumor necrosis factor)
B: tnfb (homo sapiens) (aka lymphotoxin alpha)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tnfc (homo sapiens) (aka lymphotoxin beta... | [A] |
<Instruct>: Given the context 'Antibodies against one of the two TNF binding proteins (TBPI) were found to have effects characteristic of TNF, including stimulating phosphorylation of specific cellular proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: tnfc (homo sapiens) (aka lymphotoxin beta)
D: tnfb (homo sapiens) (aka lymphotoxin alpha)
E: None of the above. | [E] |
<Instruct>: Given the context 'Oligonucleotide probes designed on the basis of the NH2-terminal amino acid sequence of TBPI were used to clone the cDNA for the structurally related cell surface type 1 TNF-R. It is notable that although this receptor can signal the phosphorylation of cellular proteins, it appears from i... | <Mentions>: [cell surface type 1 tnf-r]
<Options>: A: tnfr1 (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
C: dcr1-tnfr (homo sapiens) (aka tnf receptor superfamily member 10c)
D: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
E: None of ... | [A] |
<Instruct>: Given the context 'The extracellular domain of the receptor is composed of four internal cysteine-rich repeats, homologous to structures repeated four times in the extracellular domains of the nerve growth factor receptor and the B lymphocytes surface antigen CDw40.', select the correct biomedical concept f... | <Mentions>: [nerve growth factor receptor; cdw40]
<Options>: A: ngfr (homo sapiens) (aka nerve growth factor receptor)
B: ox40 (homo sapiens) (aka tnf receptor superfamily member 4)
C: ciliary neurotrophic factor receptor (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
D: nerve growth factor receptor (ra... | [A; I] |
<Instruct>: Given the context 'The extracellular domain of the receptor is composed of four internal cysteine-rich repeats, homologous to structures repeated four times in the extracellular domains of the nerve growth factor receptor and the B lymphocytes surface antigen CDw40.', select the correct biomedical concept f... | <Mentions>: [nerve growth factor receptor; cdw40]
<Options>: A: nerve growth factor receptor (xenopus tropicalis) (aka nerve growth factor receptor)
B: cdw40 (homo sapiens) (aka cd40 molecule)
C: ox40 (homo sapiens) (aka tnf receptor superfamily member 4)
D: cd40l (homo sapiens) (aka cd40 ligand)
E: interleukin 4 recep... | [I; B] |
<Instruct>: Given the context 'The amino acid composition and size of the extracellular domain of the type I TNF-R closely resemble those of TBPI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type i tnf-r]
<Options>: A: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
C: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
D: None of the above. | [C] |
<Instruct>: Given the context 'The COOH-terminal amino acid sequence of the four cysteine rich repeats within the extracellular domain of the type I TNF-R matches the COOH-terminal sequence of TBPI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [type i tnf-r]
<Options>: A: tnfr2 (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnf receptor superfamily member 1a (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
D: None of the above. | [B] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tbp-b (xenopus laevis) (tata-box binding protein s homeolog (xenopus laevis)) (aka tata-box binding protein s homeolog)
B: trailr2 (homo sapiens) (aka tnf receptor superfamily member 10b)
C: tnfar (homo sapiens) (aka tnf receptor superfamily member 1a)
D: t... | [J; J; C] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tbpl2 (homo sapiens) (aka tata-box binding protein like 2)
B: tata-box binding protein like 2 (bos taurus) (aka tata-box binding protein like 2)
C: tnfr2-rp (homo sapiens) (aka lymphotoxin beta receptor)
D: tbp2 (xenopus tropicalis) (aka tata-box binding pr... | [H; H; J] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tbp2 (xenopus tropicalis) (aka tata-box binding protein like 2)
B: trail-r2 (homo sapiens) (aka tnf receptor superfamily member 10b)
C: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
D: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
E... | [E; E; F] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tata-box binding protein like 2 (bos taurus) (aka tata-box binding protein like 2)
B: tnfr2-rp (homo sapiens) (aka lymphotoxin beta receptor)
C: tbp-b (xenopus laevis) (tata-box binding protein s homeolog (xenopus laevis)) (aka tata-box binding protein s ho... | [D; D; K] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein 6)
B: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
C: tnf (homo sapiens) (aka tumor necrosis factor)
D: tex6 (homo sapiens) (aka rn... | [L; H; C] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein 6)
B: hyaluronan mediated motility receptor (homo sapiens) (aka hyaluronan mediated motility receptor)
C: tumor necrosis factor (oryctolagus cuniculus) (aka tumor necrosis factor)
D: tsg-... | [F; I; M] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: tnfa (homo sapiens) (aka tumor necrosis factor)
B: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
C: cd44 (mus musculus) (aka cd44 antigen)
D: hyaluronan mediated motility receptor (homo sapiens) (aka hyaluronan media... | [L; G; A] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: tnf (homo sapiens) (aka tumor necrosis factor)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member ... | [D] |
<Instruct>: Given the context 'We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [tsg-6; tnf]
<Options>: A: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
E: testis expressed transcript, y-linked 6 ... | [F; B] |
<Instruct>: Given the context 'We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [tsg-6; tnf]
<Options>: A: tnf alpha induced protein 6 (homo sapiens) (aka tnf alpha induced protein 6)
B: tex6 (homo sapiens) (aka rna polymerase i subunit h)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tnfb (homo ... | [A; F] |
<Instruct>: Given the context 'We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [tsg-6; tnf]
<Options>: A: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
B: tnfb (homo sapiens) (aka lymphotoxin alpha)
C: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10... | [I; J] |
<Instruct>: Given the context 'In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tsg-6; tnf]
<Options>: A: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
B: tnf alpha induced protein 6 (homo sapiens) (aka tnf alpha induced protein 6)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: tnf (homo sapiens) (aka tumor necrosis factor)
E: lymphotoxin ... | [B; D] |
<Instruct>: Given the context 'In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tsg-6; tnf]
<Options>: A: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
B: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein 6)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: lymphotoxin alpha (homo sapiens) (aka lym... | [G; H] |
<Instruct>: Given the context 'The sequence of full-length TSG-6 cDNA revealed one major open reading frame predicting a polypeptide of 277 amino acids, including a typical cleavable signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [tsg-6]
<Options>: A: tex6 (homo sapiens) (aka rna polymerase i subunit h)
B: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
C: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
D: tnf alpha induced protein 6 (homo sapiens) (aka tnf alpha induced protein 6)
E: t... | [D] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
B: tex6 (homo sapiens) (aka rna polymerase i subunit h)
C: cd44 antigen (mus musculus) (aka cd44 antigen)
D: cd44 molecule (in blood group) (xenopus tropicalis) (aka cd44 molecule (in blood group))
E:... | [O; G; J] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: hyaluronan and proteoglycan link protein 1 (xenopus tropicalis) (aka hyaluronan and proteoglycan link protein 1)
B: cd44 molecule (sus scrofa) (aka cd44 molecule)
C: linkin (homo sapiens) (aka integrin alpha fg-gap repeat containing 1)
D: tnf alpha induced... | [D; E; M] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: hyaluronan and proteoglycan link protein 1 (homo sapiens) (aka hyaluronan and proteoglycan link protein 1)
B: hyaluronan and proteoglycan link protein 3 (homo sapiens) (aka hyaluronan and proteoglycan link protein 3)
C: hyaluronan and proteoglycan link pro... | [E; A; M] |
<Instruct>: Given the context 'The most extensive sequence homology exists between the predicted TSG-6 protein and CD44.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6; cd44]
<Options>: A: cd44 molecule (in blood group) (oryctolagus cuniculus) (aka cd44 molecule (in blood group))
B: tnf alpha induced protein 6 (homo sapiens) (aka tnf alpha induced protein 6)
C: cd44 molecule (in blood group) (homo sapiens) (aka cd44 molecule (in blood group))
D: cd44 molecule (sus ... | [B; C] |
<Instruct>: Given the context 'The most extensive sequence homology exists between the predicted TSG-6 protein and CD44.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6; cd44]
<Options>: A: cd44 molecule (sus scrofa) (aka cd44 molecule)
B: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
C: tsg-6 (homo sapiens) (aka tnf alpha induced protein 6)
D: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
E: cd44 (mus musculus) (aka cd44 antigen)
F: cd44 (homo sapi... | [C; F] |
<Instruct>: Given the context 'Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39-kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [tsg-6; tnf]
<Options>: A: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tnfa (homo sapiens) (... | [J; E] |
<Instruct>: Given the context 'Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39-kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [tsg-6; tnf]
<Options>: A: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
B: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: melanoma-associated transcript 6 (homo sapie... | [J; F] |
<Instruct>: Given the context 'Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39-kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [tsg-6; tnf]
<Options>: A: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
D: tnfc (homo sapiens) (aka lymphotoxin beta)... | [G; J] |
<Instruct>: Given the context 'Binding of the TSG-6 protein to hyaluronate was demonstrated by coprecipitation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6]
<Options>: A: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
B: tex6 (homo sapiens) (aka rna polymerase i subunit h)
C: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
D: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein ... | [E] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tsg6 (homo sapiens) (aka tnf alpha induced protein 6)
C: il-1a (homo sapiens) (aka interleukin 1 alpha)
D: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
E: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
F: t... | [G; J; B] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
B: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
C: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
D: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
E: testis expressed transcript, y-linked 6... | [C; M; I] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
B: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
C: ilf-1 (homo sapiens) (aka forkhead box k2)
D: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
E: il-1 (homo sapiens) ... | [L; E; J] |
<Instruct>: Given the context 'Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc2]
<Options>: A: cdc2 (homo sapiens) (cyclin dependent kinase 1 (homo sapiens)) (aka cyclin dependent kinase 1)
B: cdc27 (homo sapiens) (aka cell division cycle 27)
C: cdc28 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase cdc28)
D: anaphase promoting complex subuni... | [A] |
<Instruct>: Given the context 'We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle.', select the correct biomedical concept for each... | <Mentions>: [ched; cholinesterase-related cell division controller]
<Options>: A: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
B: crndep (homo sapiens) (aka colorectal neoplasia differentially expressed)
C: crescerin-like protein che-12 (caenorhabditis elegans) (aka c... | [A; A] |
<Instruct>: Given the context 'We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle.', select the correct biomedical concept for each... | <Mentions>: [ched; cholinesterase-related cell division controller]
<Options>: A: chedda (homo sapiens) (aka atrophin 1)
B: ched (escherichia coli str. k-12 substr. mg1655) (aka methyl-accepting chemotaxis protein tsr)
C: choline dehydrogenase (homo sapiens) (aka choline dehydrogenase)
D: ched (homo sapiens) (cyclin de... | [D; D] |
<Instruct>: Given the context 'Library screening, RNA blot hybridization, and direct PCR amplification of cDNA reverse-transcribed from cellular mRNA revealed that CHED mRNA is expressed in multiple tissues, including bone marrow.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [ched]
<Options>: A: chedda (homo sapiens) (aka atrophin 1)
B: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog)
C: ched1 (homo sapiens) (aka ovo like zinc finger 2)
D: chrd (gallus gallus) (aka chordin)
E: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent... | [E] |
<Instruct>: Given the context 'The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases, displays 34-42% identically aligned amino acid residues with other cdc2-related kinases, and is considerably longer at its amino and carboxyl termini.', select the correct biomedical... | <Mentions>: [ched]
<Options>: A: ched (escherichia coli str. k-12 substr. mg1655) (aka methyl-accepting chemotaxis protein tsr)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: ched-related (drosophila melanogaster) (aka uncharacterized protein)
D: choline dehydroge... | [B] |
<Instruct>: Given the context 'An antisense oligodeoxynucleotide designed to interrupt CHED's expression (AS-CHED) significantly reduced the ratio between CHED mRNA and actin mRNA within 1 hr of its addition to cultures, a reduction that persisted for 4 days.', select the correct biomedical concept for each mention usi... | <Mentions>: [ched]
<Options>: A: ched-related (drosophila melanogaster) (aka uncharacterized protein)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: choline dehydrogenase (homo sapiens) (aka choline dehydrogenase)
D: ched1 (homo sapiens) (aka ovo like zinc finger ... | [B] |
<Instruct>: Given the context 'An antisense oligodeoxynucleotide designed to interrupt CHED's expression (AS-CHED) significantly reduced the ratio between CHED mRNA and actin mRNA within 1 hr of its addition to cultures, a reduction that persisted for 4 days.', select the correct biomedical concept for each mention usi... | <Mentions>: [ched]
<Options>: A: ched1 (homo sapiens) (aka ovo like zinc finger 2)
B: choline dehydrogenase (homo sapiens) (aka choline dehydrogenase)
C: ched-related (drosophila melanogaster) (aka uncharacterized protein)
D: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'AS-CHED treatment selectively inhibited megakaryocyte development in murine bone marrow cultures but did not prevent other hematopoietic pathways, as evidenced by increasing numbers of mononuclear cells.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [ched]
<Options>: A: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
B: ched1 (homo sapiens) (aka ovo like zinc finger 2)
C: chegdd (homo sapiens) (aka oxidation resistance 1)
D: chrd (gallus gallus) (aka chordin)
E: ched (xenopus laevis) (aka cyclin-dependen... | [A] |
<Instruct>: Given the context 'An oligodeoxynucleotide blocking production of the acetylcholine-hydrolyzing enzyme, butyrylcholinesterase, displayed a similar inhibition of megakaryocytopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [butyrylcholinesterase]
<Options>: A: butyrylcholinesterase (sus scrofa) (aka butyrylcholinesterase)
B: butyrylcholinesterase (homo sapiens) (aka butyrylcholinesterase)
C: butyrylcholinesterase (oryctolagus cuniculus) (aka butyrylcholinesterase)
D: butyrylcholinesterase (mus musculus) (aka butyrylcholineste... | [B] |
<Instruct>: Given the context 'In contrast, an oligodeoxynucleotide blocking production of the human 2Hs cdc2 homolog interfered with production of the human 2Hs cdc2 homolog interfered with cellular proliferation without altering the cell-type composition of these cultures.', select the correct biomedical concept for ... | <Mentions>: [cdc2]
<Options>: A: cdc21 (saccharomyces cerevisiae s288c) (aka thymidylate synthase)
B: anaphase promoting complex subunit cdc23 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc23)
C: cdc27 (homo sapiens) (aka cell division cycle 27)
D: cyclin-dependent serine/threonine-protein... | [E] |
<Instruct>: Given the context 'Therefore, these findings strengthen the link between cholinergic signaling and cell division control in hematopoiesis and implicate both CHED and cholinesterases in this differentiation process.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ched]
<Options>: A: chrd (gallus gallus) (aka chordin)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: ched1 (homo sapiens) (aka ovo like zinc finger 2)
D: cesd (homo sapiens) (aka lipase a, lysosomal acid type)
E: ched (escherichia coli str. k-12 subs... | [B] |
<Instruct>: Given the context 'The transmembrane desmosomal glycoproteins have been proposed to play a role in cell adhesion; desmoglein I (DGI) is a major member of this class of desmosomal molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [desmoglein i; dgi]
<Options>: A: desmoglein 1 (xenopus tropicalis) (aka desmoglein 1)
B: dsg1 (homo sapiens) (aka desmoglein 1)
C: desmoglein 1 (sus scrofa) (aka desmoglein 1)
D: dgs-i (homo sapiens) (aka ess-2 spliceosome associated protein)
E: desmoglein 1 alpha (mus musculus) (aka desmoglein 1 alpha)
F:... | [B; B] |
<Instruct>: Given the context 'The transmembrane desmosomal glycoproteins have been proposed to play a role in cell adhesion; desmoglein I (DGI) is a major member of this class of desmosomal molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [desmoglein i; dgi]
<Options>: A: desmoglein 4 (homo sapiens) (aka desmoglein 4)
B: dgi (mus musculus) (aka desmoglein 1 alpha)
C: desmoglein 1 (homo sapiens) (aka desmoglein 1)
D: desmoglein 2 (homo sapiens) (aka desmoglein 2)
E: desmocollin 1 (homo sapiens) (aka desmocollin 1)
F: dgki (homo sapiens) (aka ... | [C; C] |
<Instruct>: Given the context 'However, evidence supporting a role for DGI in cell adhesion or in the plaque is lacking.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dgi]
<Options>: A: dg1 (homo sapiens) (aka desmoglein 1)
B: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
C: dgic (homo sapiens) (aka placenta associated 8)
D: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
E: dgi (mus musculus) (aka desmoglein 1 alpha)
F: None of the ... | [A] |
<Instruct>: Given the context 'In order to begin to understand DGI function we have identified human cDNA clones encoding the entire mature polypeptide of 1000 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [dgi]
<Options>: A: dg1 (homo sapiens) (aka desmoglein 1)
B: dgsi (mus musculus) (aka ess-2 splicing factor)
C: dgki (homo sapiens) (aka diacylglycerol kinase iota)
D: dgi (mus musculus) (aka desmoglein 1 alpha)
E: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
F: None of the above. | [A] |
<Instruct>: Given the context 'In order to begin to understand DGI function we have identified human cDNA clones encoding the entire mature polypeptide of 1000 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [dgi]
<Options>: A: dgi (mus musculus) (aka desmoglein 1 alpha)
B: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
C: dgsi (mus musculus) (aka ess-2 splicing factor)
D: dgki (homo sapiens) (aka diacylglycerol kinase iota)
E: None of the above. | [E] |
<Instruct>: Given the context 'Our data suggest that like the bovine DGI molecule human DGI is highly related to the calcium-dependent class of cell adhesion molecules known as cadherins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [dgi]
<Options>: A: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
B: dgi (mus musculus) (aka desmoglein 1 alpha)
C: dgsi (mus musculus) (aka ess-2 splicing factor)
D: dgki (homo sapiens) (aka diacylglycerol kinase iota)
E: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
... | [F] |
<Instruct>: Given the context 'The highest degree of similarity between human N-cadherin and human DGI, and likewise between bovine DGI and human DGI, is greatest in the most amino-terminal extracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [n-cadherin; dgi]
<Options>: A: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
B: dg1 (homo sapiens) (aka desmoglein 1)
C: dgi (mus musculus) (aka desmoglein 1 alpha)
D: n-cad (drosophila melanogaster) (cadherin-n (drosophila melanogaster)) (aka cadherin-n)
E: cdhn (homo sapiens) (aka cadherin 2)
F: d... | [E; B] |
<Instruct>: Given the context 'The highest degree of similarity between human N-cadherin and human DGI, and likewise between bovine DGI and human DGI, is greatest in the most amino-terminal extracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [n-cadherin; dgi]
<Options>: A: dgki (homo sapiens) (aka diacylglycerol kinase iota)
B: neural-cadherin-like (gallus gallus) (aka neural-cadherin-like)
C: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
D: dgi (mus musculus) (aka desmoglein 1 alpha)
E: dgic (homo sapiens) (aka placenta as... | [H; I] |
<Instruct>: Given the context 'The cytoplasmic portion of the molecule contains a cadherin-like region and, like bovine DGI, a carboxy-terminal tail that is not present in the cadherins, comprising three additional domains.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [dgi]
<Options>: A: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
B: dgic (homo sapiens) (aka placenta associated 8)
C: dgi (mus musculus) (aka desmoglein 1 alpha)
D: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
E: dgki (homo sapiens) (aka diacylglycerol kinase iota)
F: None of the... | [F] |
<Instruct>: Given the context 'One of these contains a novel repeating motif of 29 +/- 1 residues, first identified in bovine DGI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dgi]
<Options>: A: dgki (homo sapiens) (aka diacylglycerol kinase iota)
B: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
C: dgi (mus musculus) (aka desmoglein 1 alpha)
D: dg1 (homo sapiens) (aka desmoglein 1)
E: dgsi (mus musculus) (aka ess-2 splicing factor)
F: None of the above. | [F] |
<Instruct>: Given the context 'Five amino acids that are identical in bovine and human DGI lie in the second of the two predicted beta-strands, and intriguingly contain putative target sites for protein kinase C.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [dgi]
<Options>: A: dg1 (homo sapiens) (aka desmoglein 1)
B: dgsi (homo sapiens) (aka ess-2 spliceosome associated protein)
C: dgsi (mus musculus) (aka ess-2 splicing factor)
D: dgic (homo sapiens) (aka placenta associated 8)
E: dgi (mus musculus) (aka desmoglein 1 alpha)
F: None of the above. | [A] |
<Instruct>: Given the context 'Characterization of human loricrin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [loricrin]
<Options>: A: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
B: loricrin-like (xenopus tropicalis) (aka loricrin-like)
C: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
D: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope p... | [C] |
<Instruct>: Given the context 'We have isolated and characterized a full-length cDNA clone encoding human loricrin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [loricrin]
<Options>: A: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
B: loricrin (xenopus tropicalis) (aka loricrin)
C: loricrin (bos taurus) (aka loricrin cornified envelope precursor protein)
D: loricrin cornified envelope precursor protein (homo sapiens) (aka loricrin corn... | [D] |
<Instruct>: Given the context 'We have isolated and characterized a full-length cDNA clone encoding human loricrin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [loricrin]
<Options>: A: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
B: loricrin (xenopus tropicalis) (aka loricrin)
C: loricrin (bos taurus) (aka loricrin cornified envelope precursor protein)
D: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope precursor pro... | [E] |
<Instruct>: Given the context 'Curiously, this protein displays major differences from the recently described mouse loricrin (Mehrel, T., Hohl, D., Nakazawa, H., Rothnagel, J.A., Longley, M.A., Bundman, D., Cheng, C.K., Lichti, U., Bisher, M.E., Steven, A. C., Steinert, P.M., Yuspa, S.H., and Roop, D.R. (1990)', select... | <Mentions>: [loricrin]
<Options>: A: loricrin (bos taurus) (aka loricrin cornified envelope precursor protein)
B: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
C: loricrin-like (xenopus tropicalis) (aka loricrin-like)
D: loricrin (xenopus tropicalis) (aka loricrin)
E: loricrin cornified en... | [B] |
<Instruct>: Given the context 'Furthermore, we have isolated four peptides from purified human cell envelopes that contain recognizable loricrin sequences and which are cross-linked by the N epsilon-(gamma-glutamyl)lysine isodipeptide bond.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [loricrin]
<Options>: A: loricrin cornified envelope precursor protein (homo sapiens) (aka loricrin cornified envelope precursor protein)
B: loricrin (rattus norvegicus) (aka loricrin cornified envelope precursor protein)
C: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
D: lori... | [A] |
<Instruct>: Given the context 'The presence of such bonds thus affords an explanation for the extraordinary insolubility of loricrin by cross-linking to the cell envelope and can also explain the low steady-state levels of monomeric loricrin in cytoskeletal extracts of epidermis.', select the correct biomedical concept... | <Mentions>: [loricrin]
<Options>: A: loricrin (xenopus tropicalis) (aka loricrin)
B: loricrin (rattus norvegicus) (aka loricrin cornified envelope precursor protein)
C: loricrin-like (xenopus tropicalis) (aka loricrin-like)
D: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
E: loricrin (mus ... | [D] |
<Instruct>: Given the context 'We propose a model for the structure of loricrin in which (i) the unusual glycine-serine-rich sequences adopt a flexible loop conformation, indexed on the recurrent aliphatic residues; (ii) inter- or intramolecular isodipeptide and disulfide cross-links induce or stabilize folding of lori... | <Mentions>: [loricrin]
<Options>: A: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
B: loricrin (sus scrofa) (aka loricrin cornified envelope precursor protein)
C: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope precursor protein)
D: loricrin-like (xenopus tropicalis) (aka... | [A] |
<Instruct>: Given the context 'Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cocaine- and antidepressant-sensitive human noradrenaline transporter]
<Options>: A: net1 (homo sapiens) (solute carrier family 6 member 5 (homo sapiens)) (aka solute carrier family 6 member 5)
B: slc6a9 (homo sapiens) (aka solute carrier family 6 member 9)
C: solute carrier family 1 member 2 (homo sapiens... | [E] |
<Instruct>: Given the context 'We have isolated a complementary DNA clone encoding a human noradrenaline transporter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [noradrenaline transporter]
<Options>: A: slc6a9 (rattus norvegicus) (aka solute carrier family 6 member 9)
B: slc6a2 (rattus norvegicus) (aka solute carrier family 6 member 2)
C: slc1 (rattus norvegicus) (aka melanin-concentrating hormone receptor 1)
D: net (homo sapiens) (solute carrier family 6 member 2 ... | [D] |
<Instruct>: Given the context 'A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [ypt1; sec4]
<Options>: A: sec24d (xenopus tropicalis) (sec24 homolog c, copii coat complex component (xenopus tropicalis)) (aka sec24 homolog c, copii coat complex component)
B: ypt6 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt6)
C: ypt10 (saccharomyces cerevisiae s288c) (aka rab family gtpa... | [F; G] |
<Instruct>: Given the context 'A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [ypt1; sec4]
<Options>: A: ypt1 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt1)
B: exo4 (homo sapiens) (aka synaptotagmin like 2)
C: tpt1 (xenopus laevis) (translationally-controlled tumor protein homolog (xenopus laevis)) (aka translationally-controlled tumor protein homolog)
D: sec14 (saccha... | [A; H] |
<Instruct>: Given the context 'A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [ypt1; sec4]
<Options>: A: ypt6 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt6)
B: exo4 (homo sapiens) (aka synaptotagmin like 2)
C: sec4 (candida albicans sc5314) (aka rab family gtpase)
D: ypt1 (candida albicans sc5314) (aka rab family gtpase)
E: sec14 (saccharomyces cerevisiae s288c) (aka p... | [J; F] |
<Instruct>: Given the context 'One, the MDCK homolog of rab2, is associated with a structure having the characteristics of an intermediate compartment between the endoplasmic reticulum and the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [rab2]
<Options>: A: rab, member ras oncogene family-like 2 (mus musculus) (aka rab, member ras oncogene family-like 2)
B: rab, member of ras oncogene family like 2a (homo sapiens) (aka rab, member of ras oncogene family like 2a)
C: rab2b, member ras oncogene family (homo sapiens) (aka rab2b, member ras onc... | [E] |
<Instruct>: Given the context 'The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [rab5; rab7]
<Options>: A: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka rab7a, member ras oncogene family l homeolog)
B: rab-7 (drosophila melanogaster) (aka rab7)
C: rab5a (drosophila melanogaster) (aka rab5)
D: rab7a, member ras oncogene family (homo sapiens) ... | [G; D] |
<Instruct>: Given the context 'The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [rab5; rab7]
<Options>: A: rab7 (homo sapiens) (rab7b, member ras oncogene family (homo sapiens)) (aka rab7b, member ras oncogene family)
B: rab5a (drosophila melanogaster) (aka rab5)
C: rab7a, member ras oncogene family (homo sapiens) (aka rab7a, member ras oncogene family)
D: rab5c, member ras oncogene fa... | [E; C] |
<Instruct>: Given the context 'These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ypt1; sec4]
<Options>: A: tpt1 (xenopus laevis) (translationally-controlled tumor protein homolog (xenopus laevis)) (aka translationally-controlled tumor protein homolog)
B: ypt1 (candida albicans sc5314) (aka rab family gtpase)
C: ypt10 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt10)
D: sec... | [J; E] |
<Instruct>: Given the context 'These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ypt1; sec4]
<Options>: A: rab family gtpase ypt1 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt1)
B: sec4 (candida albicans sc5314) (aka rab family gtpase)
C: ypt1 (homo sapiens) (aka rab1a, member ras oncogene family)
D: ypt11 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt11)
E: ... | [A; F] |
<Instruct>: Given the context 'A human homologue of the yeast HDEL receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdel receptor]
<Options>: A: hdel (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 1)
B: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
C: kdelr2l (danio rerio) (aka kdel endoplasmic reticulum protein retention receptor 2b)
D: kdelr2 (danio reri... | [F] |
<Instruct>: Given the context 'There is evidence that the ERD2 gene encodes the sorting receptor that recognizes HDEL in yeast; its product is an integral membrane protein of relative molecular mass 26,000 (26K) that is not glycosylated.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [erd2]
<Options>: A: erd2l3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
B: dre2 (homo sapiens) (aka cytokine induced apoptosis inhibitor 1)
C: erdj2 (homo sapiens) (aka sec63 protein translocation regulator)
D: erda2 (homo sapiens) (aka zinc finger protein 384)
E: er lumen p... | [F] |
<Instruct>: Given the context 'In contrast, Vaux et al. suggest that the mammalian KDEL receptor is a 72K glycoprotein that they detected using an anti-idiotypic antibody approach.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [kdel receptor]
<Options>: A: kdel (lys-asp-glu-leu) endoplasmic reticulum protein retention receptor 1 (mus musculus) (aka kdel (lys-asp-glu-leu) endoplasmic reticulum protein retention receptor 1)
B: kdelr (xenopus tropicalis) (aka kdel endoplasmic reticulum protein retention receptor 3)
C: kdel endoplasm... | [C] |
<Instruct>: Given the context 'We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [erd2; kdel receptor]
<Options>: A: kdelr3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
B: erda2 (homo sapiens) (aka zinc finger protein 384)
C: dre2 (homo sapiens) (aka cytokine induced apoptosis inhibitor 1)
D: er lumen protein-retaining receptor erd-2.2 (caenorhabditis ele... | [F; F] |
<Instruct>: Given the context 'We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [erd2; kdel receptor]
<Options>: A: erd2l3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
B: kdelr3 (danio rerio) (aka kdel endoplasmic reticulum protein retention receptor 3)
C: er lumen protein-retaining receptor erd-2.2 (caenorhabditis elegans) (aka er lumen protein-retainin... | [E; E] |
<Instruct>: Given the context 'Primary structure and functional expression of rat and human stem cell factor DNAs.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor]
<Options>: A: sf (homo sapiens) (kit ligand (homo sapiens)) (aka kit ligand)
B: interleukin 7 (homo sapiens) (aka interleukin 7)
C: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
D: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
E: gm... | [A] |
<Instruct>: Given the context 'Partial cDNA and genomic clones of rat stem cell factor (SCF) have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor; scf]
<Options>: A: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
B: csf-1 (homo sapiens) (aka colony stimulating factor 1)
C: gmcsf (homo sapiens) (aka colony stimulating factor 2)
D: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
E:... | [I; I] |
<Instruct>: Given the context 'Partial cDNA and genomic clones of rat stem cell factor (SCF) have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor; scf]
<Options>: A: gmcsf (homo sapiens) (aka colony stimulating factor 2)
B: csf1 (homo sapiens) (aka colony stimulating factor 1)
C: csf3 (homo sapiens) (aka colony stimulating factor 3)
D: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
E: c-kit (homo sapien... | [J; J] |
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