instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [dna ligase iii]
<Options>: A: dna ligase 1 (homo sapiens) (aka dna ligase 1)
B: dna ligase 3 (oryctolagus cuniculus) (aka dna ligase 3)
C: lig3 (homo sapiens) (dna ligase 3 (homo sapiens)) (aka dna ligase 3)
D: ligase iii, dna, atp-dependent (xenopus tropicalis) (aka ligase iii, dna, atp-dependent)
E: liga... | [C] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
B: xrcc1 (xenopus laevis) (x-ray repair complementing defective repair in chinese hamster cells 1 l homeolog (xenopus laevis)) (aka x-ray repair complementing defective repair in ch... | [J; H; J] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: xrcc1 (oryctolagus cuniculus) (aka x-ray repair cross complementing 1)
B: aprataxin (xenopus tropicalis) (aka aprataxin)
C: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
D: aprataxin (mus musculus) (aka aprataxin)
E: xrcc1 (homo sapiens... | [G; E; G] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: x-ray repair cross complementing 1 (homo sapiens) (aka x-ray repair cross complementing 1)
B: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
C: xrcc11 (homo sapiens) (aka brca2 dna repair associated)
D: aprataxin-like (xenopus laevis) (aka aprataxin-like)
E: eay (... | [M; A; M] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: mitochondrially encoded cytochrome c oxidase iii (homo sapiens) (aka mitochondrially encoded cytochrome c oxidase iii)
C: uqcc (homo sapiens) (aka ubiquinol-cytochrome c reductase ... | [I; K; H] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: caspase-9 (mus musculus) (aka caspase 9)
B: caspase 7 (homo sapiens) (aka caspase 7)
C: cytochrome c, somatic (homo sapiens) (aka cytochrome c, somatic)
D: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
E: apak (homo sapiens) (aka... | [L; C; O] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: caspase 9 (homo sapiens) (aka caspase 9)
B: cytochrome c, somatic (homo sapiens) (aka cytochrome c, somatic)
C: casp-7 (homo sapiens) (aka caspase 7)
D: caspase-9 (mus musculus) (aka caspase 9)
E: apoptotic peptidase activating factor 1 (homo sapiens) (aka apo... | [E; B; A] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: apa-1 (homo sapiens) (aka zinc finger protein 410)
B: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
C: uqcc (homo sapiens) (aka ubiquinol-cytochrome c reductase complex assembly factor 1)
D: cytochrome c, somatic (homo sapiens) (aka cytoch... | [B; D; L] |
<Instruct>: Given the context 'It has been shown that epigenetic silencing of the APAF-1 gene is a common event in several metastatic melanoma cells in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [apaf-1]
<Options>: A: apa-1 (homo sapiens) (aka zinc finger protein 410)
B: apaf-3 (homo sapiens) (aka caspase 9)
C: apak (homo sapiens) (aka zinc finger protein 420)
D: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
E: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-relat... | [D] |
<Instruct>: Given the context 'We determined, by Western blot, variation in the level of expression of APAF-1 in several human melanoma cell lines and, by immunohistochemistry, in a group of 106 histological samples including benign and malignant melanocytic lesions.', select the correct biomedical concept for each men... | <Mentions>: [apaf-1]
<Options>: A: apak (homo sapiens) (aka zinc finger protein 420)
B: apa-1 (homo sapiens) (aka zinc finger protein 410)
C: apaf-3 (homo sapiens) (aka caspase 9)
D: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
E: apaf-1 (drosophila melanogaster) ... | [D] |
<Instruct>: Given the context 'We observed APAF-1 down-regulation or loss of expression in two metastatic melanoma cell lines, compared to primary melanoma cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apaf-3 (homo sapiens) (aka caspase 9)
C: apak (homo sapiens) (aka zinc finger protein 420)
D: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
E: apa-1 (homo sapiens) (aka zinc finger pr... | [A] |
<Instruct>: Given the context 'The immunohistochemical analysis revealed a significant difference in APAF-1 staining between nevi and melanomas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: apaf-3 (homo sapiens) (aka caspase 9)
C: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
D: apak (homo sapiens) (aka zinc finger protein 420)
E: apa-1 (... | [C] |
<Instruct>: Given the context 'The immunohistochemical analysis revealed a significant difference in APAF-1 staining between nevi and melanomas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apaf-1]
<Options>: A: apak (homo sapiens) (aka zinc finger protein 420)
B: apaf-3 (homo sapiens) (aka caspase 9)
C: apa-1 (homo sapiens) (aka zinc finger protein 410)
D: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
E: None of the above. | [E] |
<Instruct>: Given the context 'In addition, we found a significant negative correlation between APAF-1 expression level and tumor thickness and between primary melanomas and metastases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
C: apaf3 (homo sapiens) (aka caspase 9)
D: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activati... | [D] |
<Instruct>: Given the context 'We conclude that loss of APAF-1 expression can be considered as an indicator of malignant transformation in melanoma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
C: apaf-3 (homo sapiens) (aka caspase 9)
D: apak (homo sapiens) (aka zinc finger protein 420)
E: apaf-1 (xenopus tropicalis) (aka apoptoti... | [B] |
<Instruct>: Given the context 'A human cDNA was cloned that encodes a DNA-binding protein (SATB1) that is expressed predominantly in thymus and binds selectively to the nuclear matrix/scaffold-associating DNAs (MARs/SARs).', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [satb1]
<Options>: A: satb1 (rattus norvegicus) (aka satb homeobox 1)
B: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
C: satb2 (bos taurus) (aka satb homeobox 2)
D: satb1 (sus scrofa) (aka satb homeobox 1)
E: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
F: None of... | [B] |
<Instruct>: Given the context 'Missing nucleoside experiments showed that SATB1 selectively binds in a special AT-rich sequence context where one strand consists of mixed A's, T's, and C's, excluding G's (ATC sequences).', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [satb1]
<Options>: A: satb1 (homo sapiens) (aka satb homeobox 1)
B: satb1 (sus scrofa) (aka satb homeobox 1)
C: satb2 (bos taurus) (aka satb homeobox 2)
D: satb1 (rattus norvegicus) (aka satb homeobox 1)
E: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'When this feature is destroyed by mutation, SATB1 binding is greatly reduced even if the direct contact sequence remains intact.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [satb1]
<Options>: A: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
B: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
C: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
D: satb1 (homo sapiens) (aka satb homeobox 1)
E: sat2 (bos taurus) (aka spermidine/spermine n1-ac... | [D] |
<Instruct>: Given the context 'Conjunctional SATB1-binding sequences become stably unpaired in supercoiled DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb2 (bos taurus) (aka satb homeobox 2)
B: satb1 (rattus norvegicus) (aka satb homeobox 1)
C: satb1 (homo sapiens) (aka satb homeobox 1)
D: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
E: satb1 (sus scrofa) (aka satb homeobox 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Specific mutations that diminish the unwinding potential greatly reduce SATB1 binding.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
B: satb1 (sus scrofa) (aka satb homeobox 1)
C: satb2 (bos taurus) (aka satb homeobox 2)
D: satb1 (rattus norvegicus) (aka satb homeobox 1)
E: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
F: None of the above. | [E] |
<Instruct>: Given the context 'However, SATB1 does not bind single-stranded DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 (sus scrofa) (aka satb homeobox 1)
B: satb1 (rattus norvegicus) (aka satb homeobox 1)
C: satb2 (bos taurus) (aka satb homeobox 2)
D: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
E: satb1 (homo sapiens) (aka satb homeobox 1)
F: None of the above. | [E] |
<Instruct>: Given the context 'Chemical interference assays show that SATB1 binds along the minor groove with very little contact with the bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
B: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
C: satb2 (bos taurus) (aka satb homeobox 2)
D: satb1 (homo sapiens) (aka satb homeobox 1)
E: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
F: None... | [D] |
<Instruct>: Given the context 'This suggests that SATB1 recognizes the ATC sequence indirectly through the altered sugar-phosphate backbone structure present in the double-stranded DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [satb1]
<Options>: A: satb1 (rattus norvegicus) (aka satb homeobox 1)
B: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
C: satb1 (homo sapiens) (aka satb homeobox 1)
D: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
E: satb1 (sus scrofa) (aka satb homeobox 1)
F: None of... | [C] |
<Instruct>: Given the context 'This suggests that SATB1 recognizes the ATC sequence indirectly through the altered sugar-phosphate backbone structure present in the double-stranded DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [satb1]
<Options>: A: satb1 (sus scrofa) (aka satb homeobox 1)
B: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
C: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
D: satb1 (rattus norvegicus) (aka satb homeobox 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'Cloning and characterization of a human angiotensin II type 1 receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [angiotensin ii type 1 receptor]
<Options>: A: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
B: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
C: at1br (homo sapiens) (aka angiotensin ii receptor type 1)
D: angiotensin ii rece... | [C] |
<Instruct>: Given the context 'A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 angiotensin ii receptor]
<Options>: A: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
B: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
C: angiotensin ii receptor type 1 (homo sapiens) (aka angiotensin ii receptor type ... | [D] |
<Instruct>: Given the context 'Ligand binding studies of the cloned receptor expressed in COS cells suggested that it is pharmacologically a type 1 angiotensin II receptor subtype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [type 1 angiotensin ii receptor]
<Options>: A: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
B: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
C: at1r (homo sapiens) (aka angiotensin ii receptor type 1)
D: angiotensin... | [C] |
<Instruct>: Given the context 'A gene encoding a putative human RNA helicase, p54, has been cloned and mapped to the band q23.3 of chromosome 11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p54]
<Options>: A: p54 (rattus norvegicus) (aka nucleobindin 2)
B: p54 (homo sapiens) (fkbp prolyl isomerase 5 (homo sapiens)) (aka fkbp prolyl isomerase 5)
C: p54 (xenopus tropicalis) (aka dead-box helicase 6)
D: p64h1 (homo sapiens) (aka chloride intracellular channel 4)
E: p104 (homo sapiens) (aka natur... | [F] |
<Instruct>: Given the context 'The predicted amino acid sequence shares a striking homology (75% identical) with the female germline-specific RNA helicase ME31B gene of Drosophila.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [me31b]
<Options>: A: krt33b (mus musculus) (aka keratin 33b)
B: family with sequence similarity 131, member b (mus musculus) (aka family with sequence similarity 131, member b)
C: sec31 homolog b, copii coat complex component (mus musculus) (aka sec31 homolog b, copii coat complex component)
D: maternal ex... | [D] |
<Instruct>: Given the context 'Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.', select the correct biomedical concept for each mention using th... | <Mentions>: [me31b]
<Options>: A: krt33b (mus musculus) (aka keratin 33b)
B: maternal expression at 31b (drosophila melanogaster) (aka maternal expression at 31b)
C: ces31l (mus musculus) (aka carboxylesterase 3b)
D: tmem132b (mus musculus) (aka transmembrane protein 132b)
E: sec31b (mus musculus) (aka sec31 homolog b,... | [B] |
<Instruct>: Given the context 'Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [n-myc]
<Options>: A: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: myc proto-oncog... | [E] |
<Instruct>: Given the context 'The gene termed heir-1 was localized to the neuroblastoma consensus deletion at 1p36.2-p36.12.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heir-1]
<Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: heew1 (homo sapiens) (aka ectopic p-granules 5 autophagy tethering factor)
C: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
D: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
E: hef... | [A] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: lethal (1) hm452 (drosophila melanogaster) (aka lethal (1) hm452)
B: emc1 (homo sapiens) (aka er membrane protein complex subunit 1)
C: hlh462 (mus musculus) (aka inhibitor of dna binding 3)
D: er membrane complex subunit emc3 (saccharomyces cerevisiae s288c) (aka er membrane... | [C; J; G] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: ids (homo sapiens) (aka iduronate 2-sulfatase)
B: iddmx (homo sapiens) (aka diabetes mellitus, insulin-dependent, x-linked, susceptibility to)
C: emcn (mus musculus) (aka endomucin)
D: hlh462 (mus musculus) (aka inhibitor of dna binding 3)
E: id (mus musculus) (aka atpase, cl... | [D; E; M] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: emc (drosophila melanogaster) (aka extra macrochaetae)
B: emc-1 (caenorhabditis elegans) (aka er membrane protein complex subunit 1;wd_repeats_region domain-containing protein)
C: emc3 (mus musculus) (aka er membrane protein complex subunit 3)
D: iddhisd (homo sapiens) (aka t... | [M; O; A] |
<Instruct>: Given the context 'Heir-1 does not encode a basic DNA binding domain as found in basic HLH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heir-1]
<Options>: A: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
B: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
C: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
D: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
E: heir-1 (xenopus laevis) (inhib... | [C] |
<Instruct>: Given the context 'Despite prominent heir-1 expression in adrenal medulla, which is a prime target for neuroblastomas, 10 out of 12 neuroblastoma-derived cell lines revealed very low levels of heir-1 mRNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [heir-1]
<Options>: A: hef1 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
B: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
C: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
D: heed (homo sapiens) (aka embryonic ectoderm develop... | [C] |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [heir-1; n-myc]
<Options>: A: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: hin-1 (homo... | [F; J] |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [heir-1; n-myc]
<Options>: A: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
C: n-myc (mus musculus) (aka v-m... | [F; J] |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [heir-1; n-myc]
<Options>: A: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
B: nmyc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
C: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription ... | [D; B] |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [heir-1; n-myc]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
C: v-myc avian myelocytomatosis viral oncogene ne... | [B; J] |
<Instruct>: Given the context 'Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hnrnp u]
<Options>: A: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
B: hnrpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
D: heterogeneous nuclear ribonucleoprotein u (mus muscul... | [B] |
<Instruct>: Given the context 'The hnRNP U protein is an abundant nucleoplasmic phosphoprotein that is the largest of the major hnRNP proteins (120 kDa by SDS-PAGE).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
B: heterogeneous nuclear ribonucleoprotein u (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u... | [D] |
<Instruct>: Given the context 'HnRNP U binds pre-mRNA in vivo and binds both RNA and ssDNA in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
C: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
D: heterogeneous... | [A] |
<Instruct>: Given the context 'HnRNP U binds pre-mRNA in vivo and binds both RNA and ssDNA in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hnrnp u]
<Options>: A: heterogeneous nuclear ribonucleoprotein u (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
C: heterogeneous nuclear ribonucleoprotein u (mus musculus) (aka hetero... | [E] |
<Instruct>: Given the context 'Here we describe the cloning and sequencing of a cDNA encoding the hnRNP U protein, the determination of its amino acid sequence and the delineation of a region in this protein that confers RNA binding.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
C: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnp u (homo sapiens) (aka he... | [D] |
<Instruct>: Given the context 'The predicted amino acid sequence of hnRNP U contains 806 amino acids (88,939 Daltons), and shows no extensive homology to any known proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
D: hnrnpup1 (homo sapiens) (aka h... | [E] |
<Instruct>: Given the context 'Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [cytoskeletal protein 4.1]
<Options>: A: erythrocyte membrane protein band 4.1 (bos taurus) (aka erythrocyte membrane protein band 4.1)
B: erythrocyte membrane protein band 4.1-like 1 (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1-like 1)
C: erythrocyte membrane protein band 4.1 (xenopus tr... | [D] |
<Instruct>: Given the context 'We screened human megakaryoblastic cell line (MEG-01) an umbilical vein endothelial cell cDNA libraries to obtain a 3.7-kilobase cDNA designated PTPase MEG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [ptpase meg]
<Options>: A: ptpmeg (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 4)
B: ptpe (mus musculus) (aka protein tyrosine phosphatase receptor type e)
C: ptp-pest (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 12)
D: ptpmeg1 (homo sapiens) (aka protein tyrosi... | [D] |
<Instruct>: Given the context 'PTPase MEG cDNA contains an open reading frame of 926 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ptpase meg]
<Options>: A: ptpe (mus musculus) (aka protein tyrosine phosphatase receptor type e)
B: ptpmeg (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 4)
C: phosphoglycolate phosphatase (mus musculus) (aka phosphoglycolate phosphatase)
D: ptp-meg (drosophila melanogaster) (aka protei... | [B] |
<Instruct>: Given the context 'The amino-terminal region (amino acids 31-367) is 45% identical to the amino terminus of human erythrocyte protein 4.1, a cytoskeletal protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [erythrocyte protein 4.1]
<Options>: A: erythrocyte membrane protein band 4.1 (homo sapiens) (aka erythrocyte membrane protein band 4.1)
B: erythrocyte membrane protein band 4.1 like 3 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 3)
C: erythrocyte membrane protein band 4.1 like 4a (homo sa... | [A] |
<Instruct>: Given the context 'The receptor for ciliary neurotrophic factor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor]
<Options>: A: ciliary neurotrophic factor receptor (homo sapiens) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (bos taurus) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (xenopus tropicalis)... | [A] |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor; cntf]
<Options>: A: ciliary neurotrophic factor receptor (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
B: cnt1 (homo sapiens) (aka solute carrier family 28 member 1)
C: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
D: cntf (bos taurus) (aka cil... | [E; H] |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor; cntf]
<Options>: A: ckr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
B: ciliary neurotrophic factor receptor (oryctolagus cuniculus) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (homo sapiens) (aka ciliary neurotrophic ... | [C; H] |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [cntf receptor; interleukin-6]
<Options>: A: ciliary neurotrophic factor receptor (gallus gallus) (aka ciliary neurotrophic factor receptor)
B: il7 (homo sapiens) (aka interleukin 7)
C: cntfr (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
D: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
... | [E; H] |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [cntf receptor; interleukin-6]
<Options>: A: ciliary neurotrophic factor receptor (danio rerio) (aka ciliary neurotrophic factor receptor)
B: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
C: cntfr (rattus norvegicus) (aka ciliary neurotrophic f... | [F; G] |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [cntf receptor; interleukin-6 receptor]
<Options>: A: cntfr (homo sapiens) (aka ciliary neurotrophic factor receptor)
B: cntfr (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
C: interleukin 6 receptor (homo sapiens) (aka interleukin 6 receptor)
D: ciliary neurotrophic factor receptor (xenopus... | [A; C] |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [cntf receptor; interleukin-6 receptor]
<Options>: A: il6rl1 (homo sapiens) (aka interleukin 6 receptor pseudogene 1)
B: cntfr (homo sapiens) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (danio rerio) (aka ciliary neurotrophic factor receptor)
D: il6st (homo sapiens) (a... | [B; E] |
<Instruct>: Given the context 'In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [cntf receptor]
<Options>: A: ciliary neurotrophic factor receptor (gallus gallus) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
C: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
D: ciliary neurotrophic f... | [E] |
<Instruct>: Given the context 'In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [cntf receptor]
<Options>: A: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
B: ciliary neurotrophic factor receptor (gallus gallus) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (danio rerio) (aka ciliary neurotrophic factor receptor)
D: ciliary neurotrophic factor r... | [E] |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cellular retinol-binding protein type ii; rxr]
<Options>: A: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
B: rxrc (homo sapiens) (aka retinoid x receptor gamma)
C: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
D: n... | [I; E] |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cellular retinol-binding protein type ii; rxr]
<Options>: A: rxralpha (homo sapiens) (aka retinoid x receptor alpha)
B: retinol binding protein 1 (homo sapiens) (aka retinol binding protein 1)
C: rxrb (homo sapiens) (aka retinoid x receptor beta)
D: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 gr... | [E; A] |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [retinoid x receptor; rxr]
<Options>: A: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
B: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
C: rxrg (homo sapiens) (aka retinoid x receptor gamma)
D: retinoid x receptor beta (homo sapiens) (aka retinoid x receptor beta)
E: rxra... | [E; E] |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [retinoid x receptor; rxr]
<Options>: A: retinoid x receptor gamma (homo sapiens) (aka retinoid x receptor gamma)
B: lxra (homo sapiens) (aka nuclear receptor subfamily 1 group h member 3)
C: rxralpha (homo sapiens) (aka retinoid x receptor alpha)
D: rxrc (homo sapiens) (aka retinoid x receptor gamma)
E: rx... | [C; C] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: retinol binding protein 2 (xenopus tropicalis) (aka retinol binding protein 2)
B: retinol binding protein 7 (homo sapiens) (aka retinol binding protein 7)
C: crbp-iii (homo sapiens) (aka retinol binding protein 5)
D: retinol binding prote... | [F; F; L] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: rxra (homo sapiens) (aka retinoid x receptor alpha)
B: rxr-beta (homo sapiens) (aka retinoid x receptor beta)
C: rxrg (homo sapiens) (aka retinoid x receptor gamma)
D: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member ... | [G; G; A] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
B: crabp-ii (homo sapiens) (retinol binding protein 2 (homo sapiens)) (aka retinol binding protein 2)
C: reti... | [B; B; I] |
<Instruct>: Given the context 'This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [crbpii]
<Options>: A: crbpiii (homo sapiens) (aka retinol binding protein 5)
B: crbpiv (homo sapiens) (aka retinol binding protein 7)
C: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
D: crbpii (homo sapiens) (aka retinol bin... | [D] |
<Instruct>: Given the context 'The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [rxr]
<Options>: A: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
B: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
C: rxrb (homo sapiens) (aka retinoid x receptor beta)
D: rxrc (homo sapiens) (aka retinoid x receptor gamma)
E: rxr-alpha (homo sapiens) (aka retinoid x rece... | [E] |
<Instruct>: Given the context 'We have isolated a mouse cDNA of 5.7 kb, encoding a new member of the family of receptor-like protein tyrosine phosphatases, termed mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [mrptp mu]
<Options>: A: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
B: lmptp (mus musculus) (aka acid phosphatase 1, soluble)
C: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
D: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
E: r-ptp-... | [C] |
<Instruct>: Given the context 'We have isolated a mouse cDNA of 5.7 kb, encoding a new member of the family of receptor-like protein tyrosine phosphatases, termed mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [mrptp mu]
<Options>: A: r-ptp-mu (homo sapiens) (aka protein tyrosine phosphatase receptor type m)
B: lmptp (mus musculus) (aka acid phosphatase 1, soluble)
C: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
D: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
E: None... | [E] |
<Instruct>: Given the context 'In addition, we have cloned the human homologue, hRPTP mu, which shows 98.7% amino acid identity to mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrptp mu; mrptp mu]
<Options>: A: lmptp (mus musculus) (aka acid phosphatase 1, soluble)
B: r-ptp-u (homo sapiens) (aka protein tyrosine phosphatase receptor type u)
C: r-ptp-mu (homo sapiens) (aka protein tyrosine phosphatase receptor type m)
D: mrptprho (mus musculus) (aka protein tyrosine phosphatase re... | [C; E] |
<Instruct>: Given the context 'In addition, we have cloned the human homologue, hRPTP mu, which shows 98.7% amino acid identity to mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrptp mu; mrptp mu]
<Options>: A: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
B: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
C: r-ptp-mu (homo sapiens) (aka protein tyrosine phosphatase receptor type m)
D: p-ptp-mu (xenopus tropicalis) (aka protein... | [C; A] |
<Instruct>: Given the context 'The predicted mRPTP mu protein consists of a 722 amino acid extracellular region, containing 13 potential N-glycosylation sites, a single transmembrane domain and a 688 amino acid intracellular part containing 2 tandem repeats homologous to the catalytic domains of other tyrosine phosphat... | <Mentions>: [mrptp mu]
<Options>: A: mrptprho (mus musculus) (aka protein tyrosine phosphatase receptor type t)
B: p-ptp-mu (xenopus tropicalis) (aka protein tyrosine phosphatase, receptor type m)
C: lmptp (mus musculus) (aka acid phosphatase 1, soluble)
D: rptpmu (mus musculus) (aka protein tyrosine phosphatase recept... | [D] |
<Instruct>: Given the context 'Transfection of the mRPTP mu cDNA into COS cells results in the synthesis of a protein with an apparent Mr of 195,000, as detected in immunoblots using an antipeptide antibody.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [mrptp mu]
<Options>: A: p-ptp-mu (xenopus tropicalis) (aka protein tyrosine phosphatase, receptor type m)
B: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
C: trnp (mus musculus) (trna proline, mitochondrial (mus musculus)) (aka trna proline, mitochondrial)
D: rptpmu (mus musculus) (aka pro... | [D] |
<Instruct>: Given the context 'The human RPTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in human cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [rptp mu]
<Options>: A: rptpu (homo sapiens) (aka protein tyrosine phosphatase receptor type m)
B: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
C: protein tyrosine phosphatase receptor type u (homo sapiens) (aka protein tyrosine phosphatase receptor type u)
D: ptp (mus musculus) ... | [A] |
<Instruct>: Given the context 'Cytotoxic lymphocyte maturation factor (CLMF) is a disulfide-bonded heterodimeric lymphokine that (i) acts as a growth factor for activated T cells independent of interleukin 2 and (ii) synergizes with suboptimal concentrations of interleukin 2 to induce lymphokine-activated killer cells.... | <Mentions>: [interleukin 2]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: il-2 (homo sapiens) (aka interleukin 2)
D: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
E: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
F: None of th... | [C] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: hcpeb-1 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
C: bcrm1 (homo sapiens) (aka sideroflexin 4)
D: blast (homo sapiens) (aka cd48 molecule)
E: kit ligand (homo sapiens) (aka kit ligand)
F: cdcbm1 (... | [A; A; A] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
C: g protein-coupled receptor 45 (rattus norvegicus) (aka g protein-coupled receptor 45)
D: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
E: bcm1 (homo sapiens) ... | [A; A; A] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: hcpeb-1 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
B: blast-2 (homo sapiens) (aka fc epsilon receptor ii)
C: kit ligand (homo sapiens) (aka kit ligand)
D: gpr45 (rattus norvegicus) (aka g protein-coupled receptor 45)
E: bcm1 (homo sapiens) ... | [F; F; F] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: lfa-3 (... | [B; A; F] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: lfa-2 (homo sapiens) (aka cd2 molecule)
E: lfa-3 (homo sapiens) (aka cd58 molecule)
F: cd21 (homo sapiens) (aka complement c3d ... | [B; O; E] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
E: bcrm1 (homo sapiens) (aka sideroflexin 4)
F: leu... | [G; O; N] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
B: lfa3 (homo sapiens) (aka cd58 molecule)
C: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: leu-3 (homo sapiens) (aka cd4 molecule)
F: slamf3 (homo s... | [L; D; B] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: kit ligand (homo sapiens) (aka kit ligand)
B: bcm-1 (mus musculus) (aka cd48 antigen)
C: of45 (rattus norvegicus) (aka matrix extracellular phosphoglycoprotein)
D: vacuolar protein sorting 45 homolog (oryctolagus cuniculus) (aka vacuolar protein sorting 45 homolog)
E: bcm... | [B; B; M] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: bcrm1 (homo sapiens) (aka sideroflexin 4)
B: kit ligand (homo sapiens) (aka kit ligand)
C: blast-2 (homo sapiens) (aka fc epsilon receptor ii)
D: gpr45 (rattus norvegicus) (aka g protein-coupled receptor 45)
E: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
F... | [N; N; F] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
B: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
C: olr45 (rattus norvegicus) (aka olfactory receptor family 52 subfamily k member 2)
D: blast1 (homo sapiens) (aka cd48 molecule)
E: mbc1 (homo sapi... | [L; L; D] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [lfa3; cd2]
<Options>: A: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
B: cd22 molecule (homo sapiens) (aka cd22 molecule)
C: lfa-2 (homo sapiens) (aka cd2 molecule)
D: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
E: cd2 (homo sapiens) (aka cd2 molecule)
F:... | [G; E] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [lfa3; cd2]
<Options>: A: cd21 (homo sapiens) (aka complement c3d receptor 2)
B: lfa-3 (homo sapiens) (aka cd58 molecule)
C: cd2 (bos taurus) (aka cd2 molecule)
D: cd228 (homo sapiens) (aka melanotransferrin)
E: cd11a (homo sapiens) (aka integrin subunit alpha l)
F: lfa-2 (homo sapiens) (aka cd2 molecule)
G... | [B; G] |
<Instruct>: Given the context 'Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol anchor, as is the case for rat and human BCM1 antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1]
<Options>: A: bcm1 (homo sapiens) (aka cd48 molecule)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
E: cdcbm1 (homo sapiens) (aka tubul... | [A] |
<Instruct>: Given the context 'Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol anchor, as is the case for rat and human BCM1 antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1]
<Options>: A: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
B: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
E: None of the above. | [E] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
B: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
C: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
D: bcmo1 (homo sapiens) (aka bet... | [I; I; E] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: atp13a3 (homo sapiens) (aka atpase 13a3)
B: atp3 (saccharomyces cerevisiae s288c) (aka f1f0 atp synthase subunit gamma)
C: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
D: atppa3 (arabidopsis thaliana) (aka pyrophosphorylase 3)
E: bcm1 (homo sapiens) (aka cd48 mole... | [I; I; J] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: atp1a3 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 3)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: bcm1 (homo sapiens) (aka cd48 molecule)
E: bcrm1 (homo sapiens) (aka sideroflexin 4)
F: atpa... | [A; A; F] |
<Instruct>: Given the context 'A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcm1; atp1a2]
<Options>: A: atp1a2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
B: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: atp1a2 (mus musculus) (aka atpase, na+/k+ transporting, alpha 2 polypeptide)
D: bcm (homo sapiens) (aka tnf rece... | [J; A] |
<Instruct>: Given the context 'A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcm1; atp1a2]
<Options>: A: atp6a2 (homo sapiens) (aka atpase h+ transporting v0 subunit a2)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: atpase na+/k+ transporting subunit alpha 2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
D: bcrm1 (homo sapiens) (aka sideroflexin 4)
E: atp1a2 (rattu... | [B; C] |
<Instruct>: Given the context 'A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd2; lfa3]
<Options>: A: lfa3 (homo sapiens) (aka cd58 molecule)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd2 (gallus gallus) (aka cd2 molecule)
F: cd2 locus control region (homo sapiens) ... | [D; A] |
<Instruct>: Given the context 'A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd2; lfa3]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: lfa-2 (homo sapiens) (aka cd2 molecule)
D: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
E: lfa3 (homo sapiens) (aka cd58 molecule)
F: cd2 molecule (bos taurus) (ak... | [A; E] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
C: lfa-2 (homo sapiens) (aka cd2 molecule)
D: atp1a1os (homo sapiens) (aka atp1a1 antisense rna 1)
E: itga3 (homo sapiens) (aka integrin subunit alpha 3)
F: atp1a2 (homo sapien... | [A; O; S; L] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: lfa-3 (homo sapiens) (aka cd58 molecule)
B: atpiia (homo sapiens) (aka atpase phospholipid transporting 9a (putative))
C: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
D: cd2 molecule (bos taurus) (aka cd2 molecule)
E: atp6n1a (homo sapiens) (aka atpase h+ transp... | [L; A; U; F] |
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