instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Using probes based on the rat sequence, partial and full-length cDNA and genomic clones of human SCF have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scf]
<Options>: A: sf (homo sapiens) (kit ligand (homo sapiens)) (aka kit ligand)
B: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
C: csf3 (homo sapiens) (aka colony stimulating factor 3)
D: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
E: None of the above. | [A] |
<Instruct>: Given the context 'SCF is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow cultures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scf]
<Options>: A: sf (homo sapiens) (kit ligand (homo sapiens)) (aka kit ligand)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
E: None of the above. | [A] |
<Instruct>: Given the context 'SCF exhibits potent synergistic activities in conjunction with colony-stimulating factors, resulting in increased colony numbers and colony size.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scf]
<Options>: A: sf (homo sapiens) (kit ligand (homo sapiens)) (aka kit ligand)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: csf1 (homo sapiens) (aka colony stimulating factor 1)
D: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
E: None of the above. | [A] |
<Instruct>: Given the context 'Autoantibodies to a novel nuclear Ag, Sp100, have recently been described that recognize a nuclear protein with an apparent molecular mass of 95 to 100 kDa and a dot-like distribution within cell nuclei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sp100]
<Options>: A: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
B: sp100 (bos taurus) (aka sp100 nuclear antigen)
C: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
D: sp140 (homo sapiens) (aka sp140 nuclear body protein)
E: sp100-rs (mus musculus) (aka uncharacterized loc546065)
F: None of the above. | [C] |
<Instruct>: Given the context 'By immunoscreening of a lambda gt11 cDNA expression library derived from HeLa cells with an anti-Sp100 autoimmune serum a 0.7-kb cDNA (Sp26) coding for a fragment of Sp100 was isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sp100]
<Options>: A: sp100-rs (mus musculus) (aka uncharacterized loc546065)
B: crsp100 (homo sapiens) (aka mediator complex subunit 24)
C: sp100 (drosophila melanogaster) (aka jonah 44e)
D: sp100 (bos taurus) (aka sp100 nuclear antigen)
E: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
F: None of the above. | [E] |
<Instruct>: Given the context 'Expression of this cDNA and use of the recombinant protein in ELISA revealed that the fragment carries major Sp100 autoepitopes and that anti-Sp100 autoantibodies predominantly occur in patients suffering from primary biliary cirrhosis (50/184).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sp100]
<Options>: A: sp100-rs (mus musculus) (aka uncharacterized loc546065)
B: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
C: sp140 (homo sapiens) (aka sp140 nuclear body protein)
D: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
E: sp100 (drosophila melanogaster) (aka jonah 44e)
F: None of the above. | [B] |
<Instruct>: Given the context 'The Sp100 autoantigen expressed in vitro from this cDNA and authenticated by a capture immunoblot assay, comigrated in SDS-PAGE with the authentic HeLa autoantigen of 95 to 100 kDa and thus showed an aberrant electrophoretic mobility.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sp100]
<Options>: A: crsp100 (homo sapiens) (aka mediator complex subunit 24)
B: sp100 (mus musculus) (aka nuclear antigen sp100)
C: sp100 (drosophila melanogaster) (aka jonah 44e)
D: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
E: sp140 (homo sapiens) (aka sp140 nuclear body protein)
F: None of the above. | [D] |
<Instruct>: Given the context 'Computer based protein sequence analysis of the Sp100 autoantigen revealed regions of striking sequence similarities to the alpha 1 and alpha 2 domains of various human and non-human MHC class I Ag and to several transacting transcriptional regulatory proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sp100]
<Options>: A: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
B: sp100 (drosophila melanogaster) (aka jonah 44e)
C: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
D: sp140 (homo sapiens) (aka sp140 nuclear body protein)
E: crsp100 (homo sapiens) (aka mediator complex subunit 24)
F: None of the above. | [A] |
<Instruct>: Given the context 'Although cell surface receptors for the Fc region of IgA (Fc alpha R) have been implicated in a variety of immune effector mechanisms, the molecular features of Fc alpha R remain only marginally characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fc alpha r]
<Options>: A: fcgriiia (homo sapiens) (aka fc gamma receptor iiia)
B: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
C: fc alpha receptor (homo sapiens) (aka fc alpha receptor)
D: fcamr (homo sapiens) (aka fc alpha and mu receptor)
E: fcgr (homo sapiens) (aka fc gamma receptor iia)
F: None of the above. | [C] |
<Instruct>: Given the context 'Although cell surface receptors for the Fc region of IgA (Fc alpha R) have been implicated in a variety of immune effector mechanisms, the molecular features of Fc alpha R remain only marginally characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fc alpha r]
<Options>: A: fcamr (homo sapiens) (aka fc alpha and mu receptor)
B: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
C: fcgr (homo sapiens) (aka fc gamma receptor iia)
D: fcgriiia (homo sapiens) (aka fc gamma receptor iiia)
E: None of the above. | [E] |
<Instruct>: Given the context 'Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fc alpha r; fc epsilon ri]
<Options>: A: fc-gamma riii (rattus norvegicus) (aka fc gamma receptor 2a)
B: fcar (homo sapiens) (aka fc alpha receptor)
C: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
D: fcalphari (homo sapiens) (aka fc alpha receptor)
E: fc epsilon receptor ia (homo sapiens) (aka fc epsilon receptor ia)
F: fc epsilon receptor ii (homo sapiens) (aka fc epsilon receptor ii)
G: fc epsilon receptor ia (rattus norvegicus) (aka fc epsilon receptor ia)
H: fcgammariia (homo sapiens) (aka fc gamma receptor iia)
I: fcamr (homo sapiens) (aka fc alpha and mu receptor)
J: fcriiia (homo sapiens) (aka fc gamma receptor iiia)
K: None of the above. | [B; E] |
<Instruct>: Given the context 'Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fc alpha r; fc epsilon ri]
<Options>: A: fc-gamma riii (rattus norvegicus) (aka fc gamma receptor 2a)
B: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
C: fcalphar (homo sapiens) (aka fc alpha receptor)
D: fcgr (homo sapiens) (aka fc gamma receptor iia)
E: fc epsilon receptor ia (rattus norvegicus) (aka fc epsilon receptor ia)
F: fc epsilon receptor ig (homo sapiens) (aka fc epsilon receptor ig)
G: fcgriiia (homo sapiens) (aka fc gamma receptor iiia)
H: fc epsilon receptor ia (homo sapiens) (aka fc epsilon receptor ia)
I: fcgammariib (homo sapiens) (aka fc gamma receptor iib)
J: fcamr (homo sapiens) (aka fc alpha and mu receptor)
K: None of the above. | [C; H] |
<Instruct>: Given the context 'Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (bos taurus) (aka ferrochelatase)
B: ferrochelatase (gallus gallus) (aka ferrochelatase)
C: ferrochelatase (danio rerio) (aka ferrochelatase)
D: ferrochelatase (homo sapiens) (aka ferrochelatase)
E: ferrochelatase (oryctolagus cuniculus) (aka ferrochelatase)
F: None of the above. | [D] |
<Instruct>: Given the context 'The cDNA encoding human ferrochelatase', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (xenopus tropicalis) (aka ferrochelatase)
B: ferrochelatase (danio rerio) (aka ferrochelatase)
C: ferrochelatase (homo sapiens) (aka ferrochelatase)
D: ferrochelatase (caenorhabditis elegans) (aka ferrochelatase)
E: ferrochelatase-like (caenorhabditis elegans) (aka ferrochelatase-like)
F: None of the above. | [C] |
<Instruct>: Given the context '[EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ec 4.99.1.1; ferrochelatase]
<Options>: A: family with sequence similarity 99 member a (homo sapiens) (aka family with sequence similarity 99 member a)
B: dj994e9.1 (homo sapiens) (aka ribosomal protein s17 pseudogene 1)
C: ferrochelatase-like (caenorhabditis elegans) (aka ferrochelatase-like)
D: dj994e9.4 (homo sapiens) (aka olfactory receptor family 2 subfamily h member 1)
E: ferrochelatase (danio rerio) (aka ferrochelatase)
F: ferrochelatase (homo sapiens) (aka ferrochelatase)
G: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
H: ferrochelatase (caenorhabditis elegans) (aka ferrochelatase)
I: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
J: ferrochelatase (bos taurus) (aka ferrochelatase)
K: None of the above. | [K; K] |
<Instruct>: Given the context '[EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ec 4.99.1.1; ferrochelatase]
<Options>: A: dj994e9.2 (homo sapiens) (aka mas1 proto-oncogene like, g protein-coupled receptor)
B: dj994e9.6 (homo sapiens) (aka olfactory receptor family 11 subfamily a member 1)
C: dj994e9.1 (homo sapiens) (aka ribosomal protein s17 pseudogene 1)
D: ferrochelatase (homo sapiens) (aka ferrochelatase)
E: dj994e9.3 (homo sapiens) (aka ubiquitin d pseudogene 1)
F: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
G: ferrochelatase (escherichia coli str. k-12 substr. mg1655) (aka ferrochelatase)
H: dj994e9.4 (homo sapiens) (aka olfactory receptor family 2 subfamily h member 1)
I: ferrochelatase (oryctolagus cuniculus) (aka ferrochelatase)
J: ferrochelatase-like (caenorhabditis elegans) (aka ferrochelatase-like)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'Northern blot analysis showed two mRNAs of about 2500 and 1600 bp for ferrochelatase in K562 and HepG2 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (homo sapiens) (aka ferrochelatase)
B: ferrochelatase (oryctolagus cuniculus) (aka ferrochelatase)
C: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
D: ferrochelatase (caenorhabditis elegans) (aka ferrochelatase)
E: ferrochelatase (escherichia coli str. k-12 substr. mg1655) (aka ferrochelatase)
F: None of the above. | [A] |
<Instruct>: Given the context 'As full-length cDNA for human ferrochelatase is now available, molecular lesions related to erythropoietic protoporphyria can be characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase-like (caenorhabditis elegans) (aka ferrochelatase-like)
B: ferrochelatase (homo sapiens) (aka ferrochelatase)
C: ferrochelatase (gallus gallus) (aka ferrochelatase)
D: ferrochelatase (escherichia coli str. k-12 substr. mg1655) (aka ferrochelatase)
E: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
F: None of the above. | [B] |
<Instruct>: Given the context 'Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase; bile salt-stimulated milk lipase]
<Options>: A: carboxyl ester lipase (oryctolagus cuniculus) (aka carboxyl ester lipase)
B: liver carboxylesterase (sus scrofa) (aka liver carboxylesterase)
C: lipase family member m (bos taurus) (aka lipase family member m)
D: lipase h (bos taurus) (aka lipase h)
E: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
F: lipase c, hepatic type (bos taurus) (aka lipase c, hepatic type)
G: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
H: lipase e, hormone sensitive type (sus scrofa) (aka lipase e, hormone sensitive type)
I: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone sensitive type)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase; bile salt-stimulated milk lipase]
<Options>: A: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
B: carboxyl ester lipase (bos taurus) (aka carboxyl ester lipase)
C: lipase e, hormone sensitive type (sus scrofa) (aka lipase e, hormone sensitive type)
D: lipase h (bos taurus) (aka lipase h)
E: lipase e, hormone sensitive type (bos taurus) (aka lipase e, hormone sensitive type)
F: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone sensitive type)
G: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
H: carboxyl ester lipase pseudogene (homo sapiens) (aka carboxyl ester lipase pseudogene)
I: None of the above. | [A; A] |
<Instruct>: Given the context 'Three overlapping cDNA clones covering the entire primary sequence of the bile salt stimulated lipase in human milk were isolated from a human breast lambda gt10 cDNA library by screening with the rat pancreatic cholesterol esterase cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase]
<Options>: A: pancreatic lipase (homo sapiens) (aka pancreatic lipase)
B: liver carboxylesterase (sus scrofa) (aka liver carboxylesterase)
C: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone sensitive type)
D: lipase e, hormone sensitive type (rattus norvegicus) (aka lipase e, hormone sensitive type)
E: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
F: None of the above. | [F] |
<Instruct>: Given the context 'Nucleotide sequencing of the cDNA showed that the human milk lipase mRNA encodes a 748-residue protein, including a 23-residue signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [milk lipase]
<Options>: A: lipase (mus musculus) (aka lipase, endothelial)
B: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
C: monoglyceride lipase (gallus gallus) (aka monoglyceride lipase)
D: carboxyl ester lipase (bos taurus) (aka carboxyl ester lipase)
E: lipase h (gallus gallus) (aka lipase h)
F: None of the above. | [B] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: pancreatic lipase (homo sapiens) (aka pancreatic lipase)
B: lipase e, hormone sensitive type (rattus norvegicus) (aka lipase e, hormone sensitive type)
C: lipase e, hormone sensitive type (sus scrofa) (aka lipase e, hormone sensitive type)
D: lipase h (gallus gallus) (aka lipase h)
E: lipase (mus musculus) (aka lipase, endothelial)
F: monoglyceride lipase (gallus gallus) (aka monoglyceride lipase)
G: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone sensitive type)
H: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
I: cocaine esterase (oryctolagus cuniculus) (loc127491327 (oryctolagus cuniculus)) (aka cocaine esterase)
J: pancreatic triacylglycerol lipase-like (gallus gallus) (aka pancreatic triacylglycerol lipase-like)
K: carboxylesterase 1 (homo sapiens) (aka carboxylesterase 1)
L: carboxyl ester lipase pseudogene (homo sapiens) (aka carboxyl ester lipase pseudogene)
M: carboxyl ester lipase (oryctolagus cuniculus) (aka carboxyl ester lipase)
N: None of the above. | [H; N; H] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: carboxyl ester lipase (bos taurus) (aka carboxyl ester lipase)
B: lipase h (bos taurus) (aka lipase h)
C: lipase, gastric (mus musculus) (aka lipase, gastric)
D: liver carboxylesterase (sus scrofa) (aka liver carboxylesterase)
E: pancreatic lipase (bos taurus) (aka pancreatic lipase)
F: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
G: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
H: carboxyl ester lipase (oryctolagus cuniculus) (aka carboxyl ester lipase)
I: neutral cholesterol ester hydrolase 1 (homo sapiens) (aka neutral cholesterol ester hydrolase 1)
J: esterase d (oryctolagus cuniculus) (aka esterase d)
K: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
L: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone sensitive type)
M: None of the above. | [F; M; F] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
B: lipase (mus musculus) (aka lipase, endothelial)
C: lipase h (gallus gallus) (aka lipase h)
D: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
E: carboxyl ester lipase pseudogene (homo sapiens) (aka carboxyl ester lipase pseudogene)
F: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone sensitive type)
G: carboxylesterase 1 (homo sapiens) (aka carboxylesterase 1)
H: carboxyl ester lipase (gallus gallus) (aka carboxyl ester lipase)
I: pancreatic lipase (homo sapiens) (aka pancreatic lipase)
J: lipase e, hormone sensitive type (rattus norvegicus) (aka lipase e, hormone sensitive type)
K: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
L: pancreatic lipase (bos taurus) (aka pancreatic lipase)
M: None of the above. | [A; M; A] |
<Instruct>: Given the context 'This conclusion was confirmed by isolation and sequencing of the cDNA for human pancreatic cholesterol esterase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase]
<Options>: A: carboxyl ester lipase (oryctolagus cuniculus) (aka carboxyl ester lipase)
B: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
C: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
D: pancreatic lipase (homo sapiens) (aka pancreatic lipase)
E: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
F: None of the above. | [E] |
<Instruct>: Given the context 'Analysis of the sequence for the human cholesterol esterase/milk lipase revealed similarities to other serine esterases in three distinct regions of the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cholesterol esterase; milk lipase]
<Options>: A: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
B: lipase h (bos taurus) (aka lipase h)
C: pancreatic lipase (bos taurus) (aka pancreatic lipase)
D: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
E: cocaine esterase (oryctolagus cuniculus) (loc127491327 (oryctolagus cuniculus)) (aka cocaine esterase)
F: lipase, gastric (mus musculus) (aka lipase, gastric)
G: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
H: pancreatic triacylglycerol lipase-like (gallus gallus) (aka pancreatic triacylglycerol lipase-like)
I: neutral cholesterol ester hydrolase 1 (homo sapiens) (aka neutral cholesterol ester hydrolase 1)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'Analysis of the sequence for the human cholesterol esterase/milk lipase revealed similarities to other serine esterases in three distinct regions of the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cholesterol esterase; milk lipase]
<Options>: A: cocaine esterase (oryctolagus cuniculus) (loc127491327 (oryctolagus cuniculus)) (aka cocaine esterase)
B: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
C: lipase, gastric (mus musculus) (aka lipase, gastric)
D: pancreatic triacylglycerol lipase-like (gallus gallus) (aka pancreatic triacylglycerol lipase-like)
E: pancreatic lipase (bos taurus) (aka pancreatic lipase)
F: neutral cholesterol ester hydrolase 1 (homo sapiens) (aka neutral cholesterol ester hydrolase 1)
G: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
H: lipase h (bos taurus) (aka lipase h)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'Analysis of the sequence for the human cholesterol esterase/milk lipase revealed similarities to other serine esterases in three distinct regions of the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cholesterol esterase; milk lipase]
<Options>: A: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
B: neutral cholesterol ester hydrolase 1 (homo sapiens) (aka neutral cholesterol ester hydrolase 1)
C: lipase h (gallus gallus) (aka lipase h)
D: carboxylesterase 1 (homo sapiens) (aka carboxylesterase 1)
E: carboxyl ester lipase (bos taurus) (aka carboxyl ester lipase)
F: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
G: carboxyl ester lipase (gallus gallus) (aka carboxyl ester lipase)
H: lipase, gastric (mus musculus) (aka lipase, gastric)
I: carboxylesterase 1 (oryctolagus cuniculus) (aka carboxylesterase 1)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'Complete primary structure of the E1 beta subunit of human branched chain alpha-ketoacid dehydrogenase complex deduced from the nucleotide sequence and a gene analysis of patients with this disease.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta subunit]
<Options>: A: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
B: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
C: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
D: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
E: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
F: None of the above. | [C] |
<Instruct>: Given the context 'A defect in the E1 beta subunit of the branched chain alpha-ketoacid dehydrogenase (BCKDH) complex is one cause of maple syrup urine disease (MSUD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta subunit]
<Options>: A: pdhe1b (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
B: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
C: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
D: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
E: e1b (homo sapiens) (branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens)) (aka branched chain keto acid dehydrogenase e1 subunit beta)
F: None of the above. | [E] |
<Instruct>: Given the context 'In an attempt to elucidate the molecular basis of MSUD, we isolated and characterized a 1.35 kbp cDNA clone encoding the entire precursor of the E1 beta subunit of BCKDH complex from a human placental cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta subunit]
<Options>: A: e1b (homo sapiens) (branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens)) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
C: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
D: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
E: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
F: None of the above. | [A] |
<Instruct>: Given the context 'Nucleotide sequence analysis revealed that the isolated cDNA clone (lambda hBE1 beta-1) contained a 5'-untranslated sequence of four nucleotides, the translated sequence of 1,176 nucleotides and the 3'-untranslated sequence of 169 nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbe1 beta-1]
<Options>: A: calcium voltage-gated channel auxiliary subunit beta 1 (homo sapiens) (aka calcium voltage-gated channel auxiliary subunit beta 1)
B: hbe1 (homo sapiens) (aka hemoglobin subunit epsilon 1)
C: cyclic nucleotide gated channel subunit beta 1 (homo sapiens) (aka cyclic nucleotide gated channel subunit beta 1)
D: thrbeta1 (homo sapiens) (aka thyroid hormone receptor beta)
E: g protein subunit beta 1 (homo sapiens) (aka g protein subunit beta 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'Comparison of the amino acid sequence predicted from the nucleotide sequence of the cDNA insert of the clone with the NH2-terminal amino acid sequence of the purified mature bovine BCKDH-E1 beta subunit showed that the cDNA insert encodes for a 342-amino acid subunit with a Mr = 37,585.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bckdh-e1 beta subunit]
<Options>: A: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: pdhe1b (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
C: bckdh e1-beta (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
D: None of the above. | [D] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
B: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
C: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
D: e1c (homo sapiens) (aka small nucleolar rna, h/aca box 73b)
E: bckdh e1-beta (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
F: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
G: bckde1b (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
H: pdhe1b (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
I: branched chain keto acid dehydrogenase e1 subunit beta (sus scrofa) (aka branched chain keto acid dehydrogenase e1 subunit beta)
J: e1betad (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
K: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
L: branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
M: None of the above. | [L; M; L] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: e1c (homo sapiens) (aka small nucleolar rna, h/aca box 73b)
B: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
C: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
D: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
E: bckdh e1-beta (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
F: bckde1b (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
G: e1betad (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
H: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
I: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
J: pdhe1b (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
K: branched chain keto acid dehydrogenase e1 subunit beta (sus scrofa) (aka branched chain keto acid dehydrogenase e1 subunit beta)
L: None of the above. | [L; L; L] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: e1b (mus musculus) (aka small nucleolar rna, h/aca box 73a)
B: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
C: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
D: e1c (homo sapiens) (aka small nucleolar rna, h/aca box 73b)
E: bckde1b (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
F: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
G: branched chain keto acid dehydrogenase e1 subunit beta (sus scrofa) (aka branched chain keto acid dehydrogenase e1 subunit beta)
H: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
I: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
J: e1betad (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
K: None of the above. | [B; K; B] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
C: e1b (mus musculus) (aka small nucleolar rna, h/aca box 73a)
D: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
E: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
F: pdhe1b (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
G: branched chain keto acid dehydrogenase e1 subunit beta (sus scrofa) (aka branched chain keto acid dehydrogenase e1 subunit beta)
H: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
I: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
J: None of the above. | [B; J; B] |
<Instruct>: Given the context 'Genomic DNA from lymphoblastoid cell lines derived from normal and five MSUD patients, in whom E1 beta was not detected by immunoblot analysis, gave the same restriction maps on Southern blot analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e1 beta]
<Options>: A: e1betad (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
B: e1b (mus musculus) (aka small nucleolar rna, h/aca box 73a)
C: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
D: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
E: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
F: None of the above. | [E] |
<Instruct>: Given the context 'Sequence and expression of a human type II mesothelial keratin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type ii mesothelial keratin]
<Options>: A: krt222 (mus musculus) (aka keratin 222)
B: krt1-2 (mus musculus) (aka keratin 32)
C: krt-2 (mus musculus) (aka keratin 1 complex)
D: keratin 2 (mus musculus) (aka keratin 2)
E: keratin 2 (homo sapiens) (aka keratin 2)
F: None of the above. | [F] |
<Instruct>: Given the context 'A cloned cDNA encoding keratin K7 (55 kD) was identified by positive hybrid selection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [k7]
<Options>: A: keratin 7 (mus musculus) (aka keratin 7)
B: k6a (mus musculus) (aka keratin 6a)
C: krt7 (homo sapiens) (aka keratin 7)
D: k8 (mus musculus) (aka keratin 8)
E: k9 (mus musculus) (aka keratin 9)
F: None of the above. | [C] |
<Instruct>: Given the context 'Southern Blot analysis indicated that this sequence is represented only once in the human genome, and Northern Blot analysis demonstrated that the gene encoding K7 is expressed in abundance in cultured bronchial and mesothelial cells, but only weakly in cultured epidermal cells and not at all in liver, colon, or exocervical tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [k7]
<Options>: A: k6a (mus musculus) (aka keratin 6a)
B: k7 (mus musculus) (keratin 7 (mus musculus)) (aka keratin 7)
C: k7 (homo sapiens) (keratin 7 (homo sapiens)) (aka keratin 7)
D: k77 (mus musculus) (aka keratin 77)
E: k6 (mus musculus) (aka keratin 6)
F: None of the above. | [C] |
<Instruct>: Given the context 'Southern Blot analysis indicated that this sequence is represented only once in the human genome, and Northern Blot analysis demonstrated that the gene encoding K7 is expressed in abundance in cultured bronchial and mesothelial cells, but only weakly in cultured epidermal cells and not at all in liver, colon, or exocervical tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [k7]
<Options>: A: k7 (mus musculus) (keratin 7 (mus musculus)) (aka keratin 7)
B: k77 (mus musculus) (aka keratin 77)
C: k6a (mus musculus) (aka keratin 6a)
D: k6 (mus musculus) (aka keratin 6)
E: None of the above. | [E] |
<Instruct>: Given the context 'The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells: whereas all of the epidermal type II keratins thus far sequenced have long nonhelical termini rich in glycine and serine, this mesothelial type II keratin has amino and carboxy terminal regions that are unusually short and lack the inexact repeats of glycine and serine residues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mesothelial type ii keratin]
<Options>: A: keratin 2 (homo sapiens) (aka keratin 2)
B: keratin 2 (mus musculus) (aka keratin 2)
C: krt-2.6 (mus musculus) (aka keratin 6)
D: krt2-1 (mus musculus) (aka keratin 1)
E: krt222 (mus musculus) (aka keratin 222)
F: None of the above. | [F] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: rp97 (homo sapiens) (aka von willebrand factor a domain containing 8)
C: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
F: melanotransferrin (mus musculus) (aka melanotransferrin)
G: map97 (homo sapiens) (aka melanotransferrin)
H: transmembrane protein 97 (xenopus tropicalis) (aka transmembrane protein 97)
I: cep97 (homo sapiens) (aka centrosomal protein 97)
J: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin)
K: melanotransferrin (bos taurus) (aka melanotransferrin)
L: p97 (bos taurus) (aka valosin containing protein)
M: None of the above. | [G; G; G] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
B: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin)
C: map97 (homo sapiens) (aka melanotransferrin)
D: ct97 (homo sapiens) (aka lymphocyte antigen 6 family member k)
E: ppp1r97 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
F: melanotransferrin (gallus gallus) (aka melanotransferrin)
G: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
H: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
I: cilia and flagella associated protein 97 (homo sapiens) (aka cilia and flagella associated protein 97)
J: transmembrane protein 97 (xenopus tropicalis) (aka transmembrane protein 97)
K: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
L: melanotransferrin (xenopus tropicalis) (aka melanotransferrin)
M: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
N: None of the above. | [C; C; C] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
C: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
D: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
E: melanotransferrin (gallus gallus) (aka melanotransferrin)
F: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
G: cilia and flagella associated protein 97 (homo sapiens) (aka cilia and flagella associated protein 97)
H: melanotransferrin (rattus norvegicus) (aka melanotransferrin)
I: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin)
J: map97 (homo sapiens) (aka melanotransferrin)
K: ct97 (homo sapiens) (aka lymphocyte antigen 6 family member k)
L: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
M: cep97 (homo sapiens) (aka centrosomal protein 97)
N: None of the above. | [J; J; J] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
C: cilia and flagella associated protein 97 (homo sapiens) (aka cilia and flagella associated protein 97)
D: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
E: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
F: ct97 (homo sapiens) (aka lymphocyte antigen 6 family member k)
G: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin)
H: melanotransferrin (gallus gallus) (aka melanotransferrin)
I: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
J: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
K: cep97 (homo sapiens) (aka centrosomal protein 97)
L: melanotransferrin (rattus norvegicus) (aka melanotransferrin)
M: None of the above. | [M; M; M] |
<Instruct>: Given the context 'To determine the structure of this tumor-associated antigen and to identify its functional domains, we have purified and cloned p97 mRNA and determined its nucleotide sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97]
<Options>: A: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
C: map97 (homo sapiens) (aka melanotransferrin)
D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'The mRNA encodes a 738-residue precursor, which contains the previously determined N-terminal amino acid sequence of p97.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97]
<Options>: A: p97 (bos taurus) (aka valosin containing protein)
B: map97 (homo sapiens) (aka melanotransferrin)
C: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
D: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'After removal of a 19-residue signal peptide, the mature p97 molecule comprises extracellular domains of 342 and 352 residues and a C-terminal 25-residue stretch of predominantly uncharged and hydrophobic amino acids, which we believe acts as a membrane anchor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97]
<Options>: A: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
B: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
C: p97 (bos taurus) (aka valosin containing protein)
D: map97 (homo sapiens) (aka melanotransferrin)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'Protease digestion studies show that the three major antigenic determinants of p97 are present on the N-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97]
<Options>: A: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
B: p97 (bos taurus) (aka valosin containing protein)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
E: map97 (homo sapiens) (aka melanotransferrin)
F: None of the above. | [E] |
<Instruct>: Given the context 'The domains are strikingly homologous to each other (46% amino acid sequence homology) and to the corresponding domains of human serum transferrin (39% homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [transferrin]
<Options>: A: transferrin (homo sapiens) (aka transferrin)
B: tfrc (homo sapiens) (aka transferrin receptor)
C: tfrc (gallus gallus) (aka transferrin receptor)
D: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
E: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
F: None of the above. | [A] |
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; transferrin]
<Options>: A: transferrin (homo sapiens) (aka transferrin)
B: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
C: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
D: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
E: p97 (bos taurus) (aka valosin containing protein)
F: transferrin receptor (gallus gallus) (aka transferrin receptor)
G: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
H: map97 (homo sapiens) (aka melanotransferrin)
I: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
J: tfr (homo sapiens) (aka transferrin receptor)
K: None of the above. | [H; A] |
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; transferrin]
<Options>: A: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
B: transferrin (homo sapiens) (aka transferrin)
C: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
D: tfrc (gallus gallus) (aka transferrin receptor)
E: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
F: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
G: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
H: map97 (homo sapiens) (aka melanotransferrin)
I: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
J: tfr (homo sapiens) (aka transferrin receptor)
K: None of the above. | [H; B] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: lactotransferrin (rattus norvegicus) (aka lactotransferrin)
B: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
C: map97 (homo sapiens) (aka melanotransferrin)
D: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
E: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
F: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin)
G: melanotransferrin (mus musculus) (aka melanotransferrin)
H: melanotransferrin (gallus gallus) (aka melanotransferrin)
I: melanotransferrin (bos taurus) (aka melanotransferrin)
J: lactoferrin (xenopus laevis) (transferrin s homeolog (xenopus laevis)) (aka transferrin s homeolog)
K: transferrin receptor (homo sapiens) (aka transferrin receptor)
L: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin)
M: serotransferrin (glycine max) (aka serotransferrin)
N: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
O: lactoferrin (xenopus laevis) (transferrin l homeolog (xenopus laevis)) (aka transferrin l homeolog)
P: lactotransferrin (homo sapiens) (aka lactotransferrin)
Q: lactotransferrin (sus scrofa) (aka lactotransferrin)
R: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
S: None of the above. | [C; C; L; P] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: melanotransferrin (gallus gallus) (aka melanotransferrin)
C: serotransferrin (glycine max) (aka serotransferrin)
D: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin)
E: transferrin (sus scrofa) (aka transferrin)
F: lactotransferrin (mus musculus) (aka lactotransferrin)
G: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
H: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
I: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
J: melanotransferrin (mus musculus) (aka melanotransferrin)
K: lactoferrin (xenopus laevis) (transferrin l homeolog (xenopus laevis)) (aka transferrin l homeolog)
L: lactotransferrin (homo sapiens) (aka lactotransferrin)
M: lactotransferrin (sus scrofa) (aka lactotransferrin)
N: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
O: transferrin receptor (homo sapiens) (aka transferrin receptor)
P: ferritin light chain (homo sapiens) (aka ferritin light chain)
Q: melanotransferrin (xenopus tropicalis) (aka melanotransferrin)
R: map97 (homo sapiens) (aka melanotransferrin)
S: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
T: None of the above. | [R; R; D; L] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: lactotransferrin (bos taurus) (aka lactotransferrin)
C: otoferlin (homo sapiens) (aka otoferlin)
D: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin)
G: lactotransferrin (oryctolagus cuniculus) (aka lactotransferrin)
H: ferritin light chain (homo sapiens) (aka ferritin light chain)
I: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
J: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
K: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
L: lactotransferrin (homo sapiens) (aka lactotransferrin)
M: melanotransferrin (mus musculus) (aka melanotransferrin)
N: melanotransferrin (rattus norvegicus) (aka melanotransferrin)
O: serotransferrin (glycine max) (aka serotransferrin)
P: melanotransferrin (bos taurus) (aka melanotransferrin)
Q: transferrin (sus scrofa) (aka transferrin)
R: map97 (homo sapiens) (aka melanotransferrin)
S: lactoferrin (xenopus laevis) (transferrin s homeolog (xenopus laevis)) (aka transferrin s homeolog)
T: None of the above. | [R; R; F; L] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
B: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
C: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
D: lactotransferrin (homo sapiens) (aka lactotransferrin)
E: lactoferrin (xenopus laevis) (transferrin l homeolog (xenopus laevis)) (aka transferrin l homeolog)
F: melanotransferrin (xenopus tropicalis) (aka melanotransferrin)
G: otoferlin (homo sapiens) (aka otoferlin)
H: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
I: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin)
J: map97 (homo sapiens) (aka melanotransferrin)
K: lactotransferrin (mus musculus) (aka lactotransferrin)
L: lactotransferrin (sus scrofa) (aka lactotransferrin)
M: melanotransferrin (rattus norvegicus) (aka melanotransferrin)
N: lactoferrin (xenopus tropicalis) (aka transferrin)
O: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
P: melanotransferrin (mus musculus) (aka melanotransferrin)
Q: transferrin receptor (homo sapiens) (aka transferrin receptor)
R: hemiferrin, transferrin-like protein (rattus norvegicus) (aka hemiferrin, transferrin-like protein)
S: None of the above. | [J; J; I; D] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [transferrin]
<Options>: A: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
B: tfr (homo sapiens) (aka transferrin receptor)
C: transferrin (homo sapiens) (aka transferrin)
D: tfrc (gallus gallus) (aka transferrin receptor)
E: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calcineurin b]
<Options>: A: can (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b)
B: prkcbb (xenopus tropicalis) (aka protein kinase c beta)
C: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1b)
D: calnb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta)
E: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have identified and cloned human cDNA for the Ca2+-binding subunit of calcineurin, the brain isozyme of the Ca2+/calmodulin-stimulated protein phosphatase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ca2+-binding subunit of calcineurin]
<Options>: A: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha)
B: calna1 (homo sapiens) (aka protein phosphatase 3 catalytic subunit alpha)
C: calb (homo sapiens) (aka calbindin 1)
D: caln1 (homo sapiens) (aka calneuron 1)
E: cngb1 (xenopus tropicalis) (aka cyclic nucleotide gated channel beta 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'The deduced sequence of the human protein differs from bovine brain calcineurin B by an additional valine at the carboxyl terminus and substitution of Met-11 and Ser-153 by cysteine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calcineurin b]
<Options>: A: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1b)
B: calnb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta)
C: prkcbb (xenopus tropicalis) (aka protein kinase c beta)
D: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
E: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha)
F: None of the above. | [E] |
<Instruct>: Given the context 'As was observed with protein levels, mRNA abundance in brain is 20-60 times that found in other tissues with the exception of HeLa cells which, like brain, contain abundant calcineurin B mRNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calcineurin b]
<Options>: A: can (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b)
B: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1b)
C: protein phosphatase 3 regulatory subunit b, beta (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, beta)
D: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
E: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha)
F: None of the above. | [E] |
<Instruct>: Given the context 'As was observed with protein levels, mRNA abundance in brain is 20-60 times that found in other tissues with the exception of HeLa cells which, like brain, contain abundant calcineurin B mRNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calcineurin b]
<Options>: A: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
B: can (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b)
C: protein phosphatase 3 regulatory subunit b, beta (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, beta)
D: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1b)
E: None of the above. | [E] |
<Instruct>: Given the context 'Human liver serine dehydratase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase)
B: serine dehydratase like (homo sapiens) (aka serine dehydratase like)
C: serine dehydratase (bos taurus) (aka serine dehydratase)
D: serine dehydratase like (bos taurus) (aka serine dehydratase like)
E: serine dehydratase (xenopus tropicalis) (aka serine dehydratase)
F: None of the above. | [A] |
<Instruct>: Given the context 'Rat liver serine dehydratase cDNA was used to screen a human liver cDNA library in lambda gt11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (homo sapiens) (aka serine dehydratase)
B: serine dehydratase (oryctolagus cuniculus) (aka serine dehydratase)
C: serine dehydratase like (homo sapiens) (aka serine dehydratase like)
D: serine dehydratase (bos taurus) (aka serine dehydratase)
E: serine dehydratase (sus scrofa) (aka serine dehydratase)
F: None of the above. | [F] |
<Instruct>: Given the context 'The deduced amino acid sequence, with a calculated Mr of 34,615, was similar to that of rat liver serine dehydratase except for the absence of a segment consisting of 36 amino acid residues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
B: serine dehydratase (sus scrofa) (aka serine dehydratase)
C: serine dehydratase (homo sapiens) (aka serine dehydratase)
D: serine dehydratase like (bos taurus) (aka serine dehydratase like)
E: serine dehydratase (xenopus tropicalis) (aka serine dehydratase)
F: None of the above. | [F] |
<Instruct>: Given the context 'In vitro transcription/translation with the cDNA resulted in the formation of a polypeptide with an Mr of approximately 35,000, which cross-reacted with the anti-rat serine dehydratase antibody.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like)
B: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase)
C: serine dehydratase like (homo sapiens) (aka serine dehydratase like)
D: serine dehydratase (sus scrofa) (aka serine dehydratase)
E: serine dehydratase (bos taurus) (aka serine dehydratase)
F: None of the above. | [F] |
<Instruct>: Given the context 'These results suggest that the human serine dehydratase is structurally cognate with the rat enzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (oryctolagus cuniculus) (aka serine dehydratase)
B: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like)
C: serine dehydratase like (homo sapiens) (aka serine dehydratase like)
D: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase)
E: serine dehydratase like (bos taurus) (aka serine dehydratase like)
F: None of the above. | [D] |
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
B: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase 1)
C: p21-rac2 (homo sapiens) (aka rac family small gtpase 2)
D: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
E: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
F: rac (homo sapiens) (aka akt serine/threonine kinase 1)
G: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
H: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
I: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
J: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
K: None of the above. | [B; C] |
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
B: rac (homo sapiens) (aka akt serine/threonine kinase 1)
C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
D: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
E: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
F: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
G: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
H: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
I: rac1 (homo sapiens) (rac family small gtpase 1 (homo sapiens)) (aka rac family small gtpase 1)
J: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
K: None of the above. | [I; F] |
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
B: rac (homo sapiens) (aka akt serine/threonine kinase 1)
C: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
D: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
E: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
F: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
G: p21-rac2 (homo sapiens) (aka rac family small gtpase 2)
H: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
I: p21-rac1 (homo sapiens) (aka rac family small gtpase 1)
J: None of the above. | [I; G] |
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac (homo sapiens) (aka akt serine/threonine kinase 1)
D: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
E: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
F: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
G: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
H: rac (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
I: rac-1 (homo sapiens) (aka rac family small gtpase 1)
J: None of the above. | [I; E] |
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
C: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
D: rac (homo sapiens) (aka akt serine/threonine kinase 1)
E: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
F: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase 1)
G: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
H: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
I: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
J: rac2 (homo sapiens) (aka rac family small gtpase 2)
K: None of the above. | [F; J] |
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
D: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
E: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
F: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
G: rac1 (homo sapiens) (rac family small gtpase 1 (homo sapiens)) (aka rac family small gtpase 1)
H: rac (homo sapiens) (aka akt serine/threonine kinase 1)
I: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
J: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
K: None of the above. | [G; E] |
<Instruct>: Given the context 'The rac transcripts, particularly rac2, display relative myeloid tissue selectivity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac2]
<Options>: A: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2)
B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
C: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac (homo sapiens) (aka akt serine/threonine kinase 1)
E: rac2 (homo sapiens) (aka rac family small gtpase 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'Both rac1 transcripts (2.4 and 1.1 kilobases (kb] increase when HL-60 cells differentiate to neutrophil-like morphology.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1]
<Options>: A: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
D: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase 1)
E: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'rac2 mRNA (1.45 kb) increases 7-9-fold and 3-fold upon differentiation of HL-60 and U937 cells, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac2]
<Options>: A: rac (homo sapiens) (aka akt serine/threonine kinase 1)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
D: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
E: p21-rac2 (homo sapiens) (aka rac family small gtpase 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'rac2 mRNA (1.45 kb) increases 7-9-fold and 3-fold upon differentiation of HL-60 and U937 cells, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac2]
<Options>: A: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac (homo sapiens) (aka akt serine/threonine kinase 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
B: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
C: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
D: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2)
E: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
F: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
G: rac (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
H: rac (homo sapiens) (aka akt serine/threonine kinase 1)
I: p21-rac1 (homo sapiens) (aka rac family small gtpase 1)
J: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
K: None of the above. | [I; C] |
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
D: rac-1 (homo sapiens) (aka rac family small gtpase 1)
E: rac2 (homo sapiens) (aka rac family small gtpase 2)
F: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
G: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
H: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
I: rac (homo sapiens) (aka akt serine/threonine kinase 1)
J: None of the above. | [D; E] |
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac (homo sapiens) (aka akt serine/threonine kinase 1)
E: rac (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
F: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
G: rac2 (homo sapiens) (aka rac family small gtpase 2)
H: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase 1)
I: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
J: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
K: None of the above. | [H; G] |
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase 1)
C: rac2 (homo sapiens) (aka rac family small gtpase 2)
D: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
E: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
F: rac (homo sapiens) (aka akt serine/threonine kinase 1)
G: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2)
H: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
I: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
J: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
K: None of the above. | [B; C] |
<Instruct>: Given the context 'Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cathepsin e]
<Options>: A: cathepsin c (homo sapiens) (aka cathepsin c)
B: ctse (homo sapiens) (aka cathepsin e)
C: peptidase e (homo sapiens) (aka peptidase e)
D: cathepsin e (mus musculus) (aka cathepsin e)
E: cathepsin e (rattus norvegicus) (aka cathepsin e)
F: None of the above. | [B] |
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cathepsin e; ctse]
<Options>: A: ctse (mus musculus) (aka cathepsin e)
B: ctsh (homo sapiens) (aka cathepsin h)
C: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
D: ctsa (homo sapiens) (aka cathepsin a)
E: cathepsin e (homo sapiens) (aka cathepsin e)
F: carboxypeptidase e (gallus gallus) (aka carboxypeptidase e)
G: cathepsin e (rattus norvegicus) (aka cathepsin e)
H: cathepsin e (gallus gallus) (aka cathepsin e)
I: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cathepsin e; ctse]
<Options>: A: carboxypeptidase e (gallus gallus) (aka carboxypeptidase e)
B: ctse (gallus gallus) (aka cathepsin e)
C: ctsh (homo sapiens) (aka cathepsin h)
D: ctse (rattus norvegicus) (aka cathepsin e)
E: cathepsin e (gallus gallus) (aka cathepsin e)
F: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
G: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
H: cathepsin e (homo sapiens) (aka cathepsin e)
I: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'The CTSE cDNA clones were identified using a set of complementary 18-base oligonucleotide probes specific for a 6-residue sequence surrounding the first active site of all previously characterized human aspartic proteinases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: ctsh (homo sapiens) (aka cathepsin h)
C: ctse (mus musculus) (aka cathepsin e)
D: cathepsin e (homo sapiens) (aka cathepsin e)
E: ctse (gallus gallus) (aka cathepsin e)
F: None of the above. | [D] |
<Instruct>: Given the context 'Sequence analysis of CTSE cDNA clones revealed a 1188-base pair open reading frame that exhibited 59% sequence identity with human pepsinogen A.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsl (homo sapiens) (aka cathepsin l)
B: cathepsin e (homo sapiens) (aka cathepsin e)
C: ctse (gallus gallus) (aka cathepsin e)
D: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
E: ctse (mus musculus) (aka cathepsin e)
F: None of the above. | [B] |
<Instruct>: Given the context 'The predicted CTSE amino acid sequence includes a 379-residue proenzyme (Mr = 40,883) and a 17-residue signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: ctse (rattus norvegicus) (aka cathepsin e)
C: ctse (gallus gallus) (aka cathepsin e)
D: ctse (homo sapiens) (aka cathepsin e)
E: ctsl (homo sapiens) (aka cathepsin l)
F: None of the above. | [D] |
<Instruct>: Given the context 'The predicted CTSE amino acid composition was consistent with that of purified material from gastric mucosa and gastric adenocarcinoma cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctse (homo sapiens) (aka cathepsin e)
B: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
C: ctsh (homo sapiens) (aka cathepsin h)
D: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
E: ctsl (homo sapiens) (aka cathepsin l)
F: None of the above. | [A] |
<Instruct>: Given the context 'Additional evidence for the identification of the CTSE cDNA clones was obtained by analysis of poly(A+) RNA isolated from CTSE-producing and -nonproducing gastric adenocarcinoma cell subclones.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsl (homo sapiens) (aka cathepsin l)
B: ctsa (homo sapiens) (aka cathepsin a)
C: ctse (gallus gallus) (aka cathepsin e)
D: ctsh (homo sapiens) (aka cathepsin h)
E: ctse (homo sapiens) (aka cathepsin e)
F: None of the above. | [E] |
<Instruct>: Given the context 'Three RNA transcripts (3.6, 2.6, and 2.1 kilobases) were identified in poly(A+) RNA isolated from a gastric adenocarcinoma cell line that produced CTSE that were absent from nonproducing subclones.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
B: ctse (homo sapiens) (aka cathepsin e)
C: ctsl (homo sapiens) (aka cathepsin l)
D: ctsh (homo sapiens) (aka cathepsin h)
E: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'CTSE contains 7 cysteine residues, of which 6 were localized by comparative maximal alignment analysis with pepsinogen A to conserved residues that form intrachain disulfide bonds.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsh (homo sapiens) (aka cathepsin h)
B: ctsl (homo sapiens) (aka cathepsin l)
C: ctse (homo sapiens) (aka cathepsin e)
D: ctse (rattus norvegicus) (aka cathepsin e)
E: ctse (gallus gallus) (aka cathepsin e)
F: None of the above. | [C] |
<Instruct>: Given the context 'CTSE contains 7 cysteine residues, of which 6 were localized by comparative maximal alignment analysis with pepsinogen A to conserved residues that form intrachain disulfide bonds.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsh (homo sapiens) (aka cathepsin h)
B: ctse (rattus norvegicus) (aka cathepsin e)
C: ctse (gallus gallus) (aka cathepsin e)
D: ctsl (homo sapiens) (aka cathepsin l)
E: None of the above. | [E] |
<Instruct>: Given the context 'The seventh cysteine residue of CTSE is located within the activation peptide region of the proenzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctse (rattus norvegicus) (aka cathepsin e)
B: ctse (mus musculus) (aka cathepsin e)
C: ctsh (homo sapiens) (aka cathepsin h)
D: ctsa (homo sapiens) (aka cathepsin a)
E: cathepsin e (homo sapiens) (aka cathepsin e)
F: None of the above. | [E] |
<Instruct>: Given the context 'We suspect that this residue forms an interchain disulfide bond and thereby determines the dimerization of CTSE proenzyme molecules that is observed under native conditions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: cathepsin e (homo sapiens) (aka cathepsin e)
C: ctse (rattus norvegicus) (aka cathepsin e)
D: ctse (gallus gallus) (aka cathepsin e)
E: ctsl (homo sapiens) (aka cathepsin l)
F: None of the above. | [B] |
<Instruct>: Given the context 'The CTSE gene was localized to human chromosome 1 by concurrent cytogenetic and cDNA probe analyses of a panel of human x mouse somatic cell hybrids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctse (mus musculus) (aka cathepsin e)
B: cathepsin e (homo sapiens) (aka cathepsin e)
C: ctsa (homo sapiens) (aka cathepsin a)
D: ctse (rattus norvegicus) (aka cathepsin e)
E: ctsl (homo sapiens) (aka cathepsin l)
F: None of the above. | [B] |
<Instruct>: Given the context 'Homology between a region of the human retinoblastoma gene and L1 family repetitive sequences.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoblastoma]
<Options>: A: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2)
B: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1)
C: rb1 (homo sapiens) (aka rb transcriptional corepressor 1)
D: rb3 (homo sapiens) (aka stathmin 4)
E: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'Five clones that hybridized weakly with the human retinoblastoma (Rb) gene were obtained by screening a human genomic library in a non-stringent condition.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoblastoma; rb]
<Options>: A: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein)
B: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1)
C: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2)
D: rb (homo sapiens) (aka rb transcriptional corepressor 1)
E: rbb (homo sapiens) (aka nacc family member 2)
F: rb3 (homo sapiens) (aka stathmin 4)
G: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2)
H: None of the above. | [D; D] |
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