instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: myc (mus musculus) (myelo... | [J; G] |
<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: yaf2 (bos taurus) (aka yy1 associated factor 2)
D: mycl (homo sapiens) (aka mycl proto-oncogene, ... | [F; G] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: yaf2 (bos taurus) (aka yy1 associated factor 2)
C: yaf2 (homo sapiens) (aka yy1 associated factor 2)
D: mycn proto-oncogene, bhlh transcription factor (rattus norvegicus) (aka mycn proto-oncoge... | [L; C; M] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: yaf2 (sus scrofa) (aka yy1 associated factor 2)
C: yaf2 (xenopus laevis) (aka yy1 associated factor 2 s homeolog)
D: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncoge... | [N; K; A] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: yaf1 (homo sapiens) (aka histone deacetylase 2)
B: yaf2-a (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis)) (aka yy1 associated factor 2 s homeolog)
C: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcriptio... | [L; M; C] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
C: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka my... | [C; L; I] |
<Instruct>: Given the context 'This differential influence on two members of the Myc family gives insight into a new mechanism to modulate the biological activities of Myc transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [myc]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
C: myc proto-oncogene, bhlh... | [C] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: elk1 (bos taurus) (aka ets transcription factor elk1)
B: blk (bos taurus) (aka blk proto-oncogene, src family tyrosine kinase)
C: hbgfr (homo sapiens) (aka fibroblast growth factor receptor 1)
D: fibroblast growth ... | [H; H; H] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: hbgfr (homo sapiens) (aka fibroblast growth factor receptor 1)
B: bek (xenopus tropicalis) (aka fibroblast growth factor receptor 2)
C: fibroblast growth factor receptor 1 (homo sapiens) (aka fibroblast growth fact... | [J; J; J] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: bek (xenopus tropicalis) (aka fibroblast growth factor receptor 2)
B: hbgfr (homo sapiens) (aka fibroblast growth factor receptor 1)
C: blk proto-oncogene, src family tyrosine kinase (bos taurus) (aka blk proto-onc... | [D; D; D] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: bek (mus musculus) (aka fibroblast growth factor receptor 2)
B: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: kgfr (homo sapiens) (aka fibroblast growth factor rece... | [C; C; C] |
<Instruct>: Given the context 'Both serine and tyrosine phosphatase activities were completely abolished by mutagenesis of a single cysteine residue conserved in VH1 and the VH1-related (VHR) human protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [vh1-related (vhr) human protein]
<Options>: A: vhr (homo sapiens) (aka dual specificity phosphatase 3)
B: vh3 (homo sapiens) (aka immunoglobulin heavy variable 3-75 (pseudogene))
C: vhx (homo sapiens) (aka dual specificity phosphatase 22)
D: vh (homo sapiens) (solute carrier family 7 member 4 (homo sapiens... | [A] |
<Instruct>: Given the context 'These properties suggest that VHR is capable of regulating intracellular events mediated by both tyrosine and serine phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [vhr]
<Options>: A: vhr2 (saccharomyces cerevisiae s288c) (aka vhr2p)
B: vhr (homo sapiens) (aka dual specificity phosphatase 3)
C: vhx (homo sapiens) (aka dual specificity phosphatase 22)
D: vho (homo sapiens) (aka growth differentiation factor 11)
E: vhr1 (saccharomyces cerevisiae s288c) (aka vhr1p)
F: No... | [B] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor nuclear translocator (xenopus tropicalis) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor nuclear translocator (gallus gallus) (aka aryl hydrocarbon receptor nuclear translocator)
... | [E; E; I] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: arno3 (homo sapiens) (aka cytohesin 3)
B: basic helix-loop-helix arnt like 1 (homo sapiens) (aka basic helix-loop-helix arnt like 1)
C: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
D: aryl hydrocarbon receptor nucl... | [G; G; E] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: arnt2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
B: aryl hydrocarbon receptor nuclear translocator (xenopus tropicalis) (aka aryl hydrocarbon receptor nuclear translocator)
C: arno3 (homo sapiens) (aka cytohesin 3... | [D; D; M] |
<Instruct>: Given the context 'The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects.', select the correct biomedical concept for each mention using the p... | <Mentions>: [ah (dioxin) receptor]
<Options>: A: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
B: aryl hydrocarbon receptor protein 1 (caenorhabditis elegans) (aka aryl hydrocarbon receptor protein 1)
C: aryl hydrocarbon receptor (... | [C] |
<Instruct>: Given the context 'The ligand-bound receptor activates Cyp 1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [cyp 1a1]
<Options>: A: cyp1 (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
B: cyp17a1 (homo sapiens) (aka cytochrome p450 family 17 subfamily a member 1)
C: cytochrome p450 family 1 subfamily a member 1 (bos taurus) (aka cyt... | [A] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: basic helix-loop-helix arnt like 1 (xenopus tropicalis) (aka basic helix-loop-helix arnt like 1)
B: arnt2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
C: aryl hydrocarbon receptor nuclear translocator (rattus norveg... | [K; K; G] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: arno3 (homo sapiens) (aka cytohesin 3)
B: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
C: aryl hydrocarbon receptor (homo sapiens) (aka aryl hydrocarbon receptor)
D: ahrr (homo sapiens) (cytochrome p450 family 1 su... | [F; F; H] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
B: aryl hydrocarbon receptor repressor (homo sapiens) (aka aryl hydrocarbon receptor repressor)
C: aryl hydrocarbon receptor nuclear translocator (rattus norvegicus) (ak... | [L; L; E] |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arnt; ah receptor]
<Options>: A: arno (homo sapiens) (aka cytohesin 2)
B: ahr (homo sapiens) (aka aryl hydrocarbon receptor)
C: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
D: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear t... | [C; B] |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arnt; ah receptor]
<Options>: A: arnt (drosophila melanogaster) (aka tango)
B: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
C: arnt2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
D: aryl hydroc... | [G; J] |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arnt; ah receptor]
<Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: arno (homo sapiens) (aka cytohesin 2)
C: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclear translocator)
D: ahrr (homo sapien... | [C; I] |
<Instruct>: Given the context 'Furthermore, Arnt and the ligand-binding subunit of the receptor were extracted as a complex from the nuclei of cells treated with ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [arnt]
<Options>: A: basic helix-loop-helix arnt like 1 (xenopus tropicalis) (aka basic helix-loop-helix arnt like 1)
B: arnt2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
C: arno3 (homo sapiens) (aka cytohesin 3)
D: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translo... | [E] |
<Instruct>: Given the context 'Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [arnt]
<Options>: A: arno3 (homo sapiens) (aka cytohesin 3)
B: arntl (homo sapiens) (aka basic helix-loop-helix arnt like 1)
C: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
D: arnt (drosophila melanogaster) (aka tango)
E: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclea... | [E] |
<Instruct>: Given the context 'Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [saf-a]
<Options>: A: scf ubiquitin ligase complex subunit saf1 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit saf1)
B: saf-b (homo sapiens) (aka scaffold attachment factor b)
C: saf-a (drosophila melanogaster) (aka uncharacterized protein)
D: saf-1 (homo sapiens) (aka myc associ... | [E] |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [scaffold attachment region; sar]
<Options>: A: saraf (homo sapiens) (aka store-operated calcium entry associated regulatory factor)
B: clk4 associating serine/arginine rich protein (bos taurus) (aka clk4 associating serine/arginine rich protein)
C: sra (drosophila melanogaster) (sarah (drosophila melanogas... | [K; K] |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [scaffold attachment region; sar]
<Options>: A: clk4 associating serine/arginine rich protein (sus scrofa) (aka clk4 associating serine/arginine rich protein)
B: receptor associated protein of the synapse (sus scrofa) (aka receptor associated protein of the synapse)
C: steroid receptor associated and regula... | [K; K] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: saf-a (drosophila melanogaster) (aka uncharacterized protein)
B: scaffold attachment factor b (xenopus tropicalis) (aka scaffold attachment factor b)
C: sar1 (arabidopsis thaliana) (suppressor of auxin resistance1 (arabidopsis thaliana)) (aka suppress... | [I; I; O] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: chromatin assembly factor 1 subunit a (sus scrofa) (aka chromatin assembly factor 1 subunit a)
B: sarnp (homo sapiens) (aka sap domain containing ribonucleoprotein)
C: sara1 (homo sapiens) (aka secretion associated ras related gtpase 1a)
D: small regu... | [J; J; O] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: nucleosome assembly factor asf1 (saccharomyces cerevisiae s288c) (aka nucleosome assembly factor asf1)
B: sra (drosophila melanogaster) (sarah (drosophila melanogaster)) (aka sarah)
C: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
D: s... | [F; F; O] |
<Instruct>: Given the context 'SAF-A is an abundant nuclear protein and a constituent of the nuclear matrix and scaffold.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [saf-a]
<Options>: A: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
B: saf-a (drosophila melanogaster) (aka uncharacterized protein)
C: saf-a (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
D: saf-b (homo sapiens) (aka scaffold attachment factor b)
E: saf-a (xenopus tropicalis... | [C] |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept for each menti... | <Mentions>: [saf-a; sar]
<Options>: A: saf-b (homo sapiens) (aka scaffold attachment factor b)
B: saf-a (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
C: sarp (homo sapiens) (aka ankyrin repeat domain 42)
D: sra (drosophila melanogaster) (sarah (drosophila melanogast... | [J; K] |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept for each menti... | <Mentions>: [saf-a; sar]
<Options>: A: saf (homo sapiens) (aka fas antisense rna 1)
B: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: saf-1 (homo sapiens) (aka myc associated zinc finger protein)
D: saf-b (homo sapiens) (aka scaffold attachment factor b)
E: saf1 (saccharomyces cerevisiae s288c) ... | [B; K] |
<Instruct>: Given the context 'Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.
', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [udp-glcnac:gal beta 1-3-galnac-r (glcnac to galnac) beta 1-6glcnac transferase]
<Options>: A: provisional ortholog of core 1 synthase, glycoprotein-n-acetylgalactosamine 3-beta-galactosyltransferase 1 (xenopus tropicalis) (aka provisional ortholog of core 1 synthase, glycoprotein-n-acetylgalactosamine 3-be... | [E] |
<Instruct>: Given the context 'A cDNA encoding UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase (EC 2.4.1.102), which forms critical branches in O-glycans, has been isolated by an expression cloning approach using Chinese hamster ovary (CHO) cells.', select the correct biomedical concept fo... | <Mentions>: [udp-glcnac:gal beta 1-3galnac-r (glcnac to galnac) beta 1-6glcnac transferase]
<Options>: A: galnact (homo sapiens) (aka beta-1,4-n-acetyl-galactosaminyltransferase 1)
B: galnt6 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 6)
C: galnt1 (homo sapiens) (aka polypeptide n-acetylgalactosam... | [D] |
<Instruct>: Given the context 'Because the antibody used was found to detect most efficiently the oligosaccharide products attached to leukosialin, the CHO cells were also stably transfected with leukosialin cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [leukosialin]
<Options>: A: spn (xenopus tropicalis) (sialophorin (xenopus tropicalis)) (aka sialophorin)
B: sialophorin (homo sapiens) (aka sialophorin)
C: sialophorin (sus scrofa) (aka sialophorin)
D: galn (homo sapiens) (aka galanin and gmap prepropeptide)
E: leukosialin-like (rattus norvegicus) (aka leu... | [B] |
<Instruct>: Given the context 'The expression of the presumed catalytic domain as a fusion protein with the IgG binding domain of protein A enabled us to demonstrate unequivocally that the cDNA encodes the core 2 beta-1,6-N-acetylglucosaminyltransferase, the enzyme responsible for the formation of Gal beta 1-3(GlcNAc b... | <Mentions>: [core 2 beta-1,6-n-acetylglucosaminyltransferase]
<Options>: A: glucosaminyl (n-acetyl) transferase 1, core 2 (mus musculus) (aka glucosaminyl (n-acetyl) transferase 1, core 2)
B: c2gnt (homo sapiens) (aka glucosaminyl (n-acetyl) transferase 1)
C: b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog;g... | [B] |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterat... | <Mentions>: [tumor necrosis factor-alpha; tnf]
<Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: tnfa (homo sapiens) (aka tumor necrosis factor)
C: tnfb (homo sapiens) (aka lymphotoxin alpha)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tnfc (homo ... | [B; B] |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterat... | <Mentions>: [tumor necrosis factor-alpha; tnf]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
D: tnf (homo sapiens) (aka tumor necrosis factor)
E: tumor necrosis factor (xeno... | [D; D] |
<Instruct>: Given the context 'We have used the technique of differential hybridization to identify several primary response genes induced by TNF in human umbilical vein endothelial (HUVE) cells, a cell type that is profoundly activated by cytokine treatment.', select the correct biomedical concept for each mention usi... | <Mentions>: [tnf]
<Options>: A: tnf (homo sapiens) (aka tumor necrosis factor)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tnfsf1 (homo sapiens) (aka lym... | [A] |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [b94; tnf]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
D: tnf (homo sapiens) (aka tumor necrosis factor)
E: rp94 (homo sapiens) (aka spermatogenesi... | [J; D] |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [b94; tnf]
<Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: cp94 (homo sapiens) (aka beaded filament structural protein 1)
D: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
E: p94 (homo sapiens) (aka cal... | [B; I] |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-1 beta; b94]
<Options>: A: ifnb (homo sapiens) (aka interferon beta 1)
B: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
C: il1beta (homo sapiens) (aka interleukin 1 beta)
D: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
E: b94 (homo sapiens) (aka t... | [C; E] |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-1 beta; b94]
<Options>: A: ifnb (homo sapiens) (aka interferon beta 1)
B: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: b94 (homo sapiens) (aka tnf alpha induced protein 2)
E: interleukin 36 beta (homo sapiens) (aka i... | [G; D] |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-1 beta; b94]
<Options>: A: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
B: ifnb (homo sapiens) (aka interferon beta 1)
C: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
D: b94 (homo sapiens) (aka tnf alpha induced protein 2)
E: hg94 (homo sapiens) (aka olfactory receptor family 7... | [H; D] |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [tnf; b94]
<Options>: A: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: b94 (homo sapiens) (aka tnf alpha induced protein 2)
F: ... | [G; E] |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [tnf; b94]
<Options>: A: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
B: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tnf superfamily member 4 ... | [B; C] |
<Instruct>: Given the context 'Further, B94 is shown to be a single copy gene that is evolutionarily conserved.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b94]
<Options>: A: cp94 (homo sapiens) (aka beaded filament structural protein 1)
B: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
E:... | [E] |
<Instruct>: Given the context 'Developmental regulation occurs most prominently in mouse embryonic liver and kidney, and a second smaller form of B94 transcript is detected in the placenta and testes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [b94]
<Options>: A: p94 (homo sapiens) (aka calpain 3)
B: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
C: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: b94 (homo sapiens) (aka tnf a... | [E] |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [b94; tnf]
<Options>: A: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
B: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member 2 pseudogene)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
E: tnf superfamil... | [C; I] |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [b94; tnf]
<Options>: A: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
D: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
E: hg94 (homo sapiens) (aka olfactory rece... | [H; C] |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [b94; tnf]
<Options>: A: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
B: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member ... | [J; B] |
<Instruct>: Given the context 'Sequence analysis of the B94 cDNA reveals an open reading frame encoding a 73-kDa polypeptide that has no homology to any known protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [b94]
<Options>: A: cp94 (homo sapiens) (aka beaded filament structural protein 1)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
E: natural killer cells antigen cd94 (b... | [B] |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept for each... | <Mentions>: [b94; tnf]
<Options>: A: tnfb (homo sapiens) (aka lymphotoxin alpha)
B: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: rp94 (homo sapiens) (aka spermatogenesis associated 7)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily memb... | [C; H] |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept for each... | <Mentions>: [b94; tnf]
<Options>: A: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: tnf superfamily memb... | [B; H] |
<Instruct>: Given the context 'A approximately 35-kDa polypeptide with a unique NH2-terminal sequence has been isolated from bovine lung and found to be present on the surface of endothelial cells where it mediates the binding of AGEs (receptor for advanced glycosylation end product or RAGE).', select the correct biome... | <Mentions>: [rage]
<Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: rage1 (homo sapiens) (aka mok protein kinase)
C: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) ... | [A] |
<Instruct>: Given the context 'Using an oligonucleotide probe based on the amino-terminal sequence of RAGE, an apparently full-length cDNA of 1.5 kilobases was isolated from a bovine lung cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [rage]
<Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: rage-1 (xenopus tropicalis) (aka mok protein kinase)
C: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos ta... | [A] |
<Instruct>: Given the context 'A partial clone encoding the human counterpart of RAGE, isolated from a human lung library, was found to be approximately 90% homologous to the bovine molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [rage]
<Options>: A: rage-1 (homo sapiens) (aka mok protein kinase)
B: en-rage (bos taurus) (aka s100 calcium binding protein a12)
C: rage (xenopus laevis) (aka mok protein kinase l homeolog)
D: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced... | [E] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: ncam1 (homo sapiens) (aka neural cell adhesion molecule 1)
B: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
C: muc18 (homo sapiens) (aka melanoma cell adhesion molecule)
D: rage (gallus gallus) (aka mok protein kinase)
E: rage (bos taurus) (advanced g... | [M; C; A] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: muc18 (homo sapiens) (aka melanoma cell adhesion molecule)
C: mucin-18 (gallus gallus) (aka melanoma cell adhesion molecu... | [A; B; F] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: muc18 (homo sapiens) (aka melanoma cell adhesion molecule)
B: ncam (homo sapiens) (aka neural cell adhesion molecule 1)
C: ncam-l1 (homo sapiens) (aka l1 cell adhesion molecule)
D: ck-18 (homo sapiens) (aka keratin 18)
E: rage (homo sapiens) (advanced glycosylation end-pro... | [E; A; B] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [cd20]
<Options>: A: cd20 (rattus norvegicus) (aka membrane spanning 4-domains a1)
B: cd20 (homo sapiens) (membrane spanning 4-domains a1 (homo sapiens)) (aka membrane spanning 4-domains a1)
C: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
D: cd20l (homo sapiens) (aka membrane spanning 4-domain... | [B] |
<Instruct>: Given the context 'Expression of the RAGE cDNA in 293 cells allowed them to bind 125I-AGE-albumin in a saturable and dose-dependent manner (Kd approximately 100 nM), blocked by antibody to RAGE.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [rage]
<Options>: A: rage-1 (xenopus tropicalis) (aka mok protein kinase)
B: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
C: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
D: en-rage ... | [C] |
<Instruct>: Given the context 'Western blots of 293 cells transfected with RAGE cDNA probed with anti-RAGE IgG demonstrated expression of immunoreactive protein compared to its absence in mock-transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [rage]
<Options>: A: rage1 (homo sapiens) (aka mok protein kinase)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
C: rage (gallus gallus) (aka mok protein kinase)
D: en-rage (bos taurus) (aka s100 calciu... | [B] |
<Instruct>: Given the context 'Western blots of 293 cells transfected with RAGE cDNA probed with anti-RAGE IgG demonstrated expression of immunoreactive protein compared to its absence in mock-transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [rage]
<Options>: A: rage (gallus gallus) (aka mok protein kinase)
B: rage1 (homo sapiens) (aka mok protein kinase)
C: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
D: en-rage (bos taurus) (aka s... | [E] |
<Instruct>: Given the context 'These results suggest that RAGE functions as a cell surface receptor for AGEs, which could potentially mediate cellular effects of this class of glycosylated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [rage]
<Options>: A: en-rage (bos taurus) (aka s100 calcium binding protein a12)
B: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
C: rage (gallus gallus) (aka mok protein kinase)
D: rage-1 (xenopus tropica... | [B] |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd59; ly-6]
<Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
B: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
C: cd51 (homo sapiens) (aka integrin subunit alpha v)
D: ly5 (homo sapiens) (aka protein tyrosine phosphatase receptor type c)
E: ly-6d (homo sapiens) (aka l... | [H; K] |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd59; ly-6]
<Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
B: lymphocyte antigen 6 family member s (homo sapiens) (aka lymphocyte antigen 6 family member s)
C: slam family member 6 (homo sapiens) (aka slam family member 6)
D: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family ... | [G; K] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: pleiotrophin promoter (homo sapiens) (aka pleiotrophin promoter)
B: mire (homo sapiens) (aka sap30 divergent transcript)
C: cd51 (homo sapiens) (aka integrin subunit alpha v)
D: cd58 (homo sapiens) (aka cd58 molecule)
E: mir (drosop... | [L; L; L; L] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: mire (homo sapiens) (aka sap30 divergent transcript)
B: intercellular adhesion molecule 1-like (bos taurus) (aka intercellular adhesion molecule 1-like)
C: proprotein convertase subtilisin/kexin type 1 inhibitor (homo sapiens) (aka ... | [M; M; M; M] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: sod (homo sapiens) (aka superoxide dismutase 1)
B: migration and invasion inhibitory protein (homo sapiens) (aka migration and invasion inhibitory protein)
C: proprotein convertase subtilisin/kexin type 1 inhibitor (homo sapiens) (a... | [K; K; K; K] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: cd58 (homo sapiens) (aka cd58 molecule)
B: mical-like (drosophila melanogaster) (aka mical-like)
C: proprotein convertase subtilisin/kexin type 1 inhibitor (homo sapiens) (aka proprotein convertase subtilisin/kexin type 1 inhibitor)... | [E; E; E; E] |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [cd59; ly-6]
<Options>: A: ly5 (homo sapiens) (aka protein tyrosine phosphatase receptor type c)
B: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
C: cd58 (homo sapiens) (aka cd58 molecule)
D: cd6 molecule (homo sapiens) (aka cd6 molecule)
E: ly-6d (homo sapiens) (aka lymphocyte antigen 6 famil... | [G; K] |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [cd59; ly-6]
<Options>: A: cd58 (homo sapiens) (aka cd58 molecule)
B: lymphocyte antigen 6 family member h (homo sapiens) (aka lymphocyte antigen 6 family member h)
C: slam family member 7 (homo sapiens) (aka slam family member 7)
D: cd6 molecule (homo sapiens) (aka cd6 molecule)
E: ly5 (homo sapiens) (aka ... | [I; K] |
<Instruct>: Given the context 'The striking similarity in gene structure is further evidence that the two proteins belong to a superfamily of proteins that may also include the urokinase plasminogen-activator receptor and a squid glycoprotein of unknown function.', select the correct biomedical concept for each mention... | <Mentions>: [urokinase plasminogen-activator receptor]
<Options>: A: urokinase plasminogen activator surface receptor-like (danio rerio) (aka urokinase plasminogen activator surface receptor-like)
B: plasminogen activator, urokinase receptor (rattus norvegicus) (aka plasminogen activator, urokinase receptor)
C: plasmin... | [E] |
<Instruct>: Given the context 'Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-1 receptor antagonist]
<Options>: A: il-1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
B: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagonist)
C: il1rp1 (homo sapiens) (aka interleukin 37)
D:... | [A] |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical conc... | <Mentions>: [interleukin-1 receptor antagonist; il-1ra]
<Options>: A: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
B: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
C: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagonist)
D: i... | [E; E] |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical conc... | <Mentions>: [interleukin-1 receptor antagonist; il-1ra]
<Options>: A: il-1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
B: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 receptor)
C: il1rp1 (homo sapiens) (aka interleukin 3... | [A; A] |
<Instruct>: Given the context 'The gene contains four exons which code for the secreted form of the IL-1ra, however, our clone does not contain the alternative first exon used to generate an intracellular form of the protein as the protein as found in epithelial cells.', select the correct biomedical concept for each m... | <Mentions>: [il-1ra]
<Options>: A: il-1racp (homo sapiens) (aka interleukin 1 receptor accessory protein)
B: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
C: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
D: icil-1ra (homo sapiens) (aka interleukin 1 receptor antagonist)
E: il-1ra (homo sapiens... | [D] |
<Instruct>: Given the context 'By in-situ fluorescence hybridization we have shown that the IL-1ra gene is found on the long arm of chromosome 2 and maps to 2q13-14.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [il-1ra]
<Options>: A: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
B: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
C: il1rap (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: il-1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin... | [D] |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [il-1 alpha; il-1 beta]
<Options>: A: il1b (homo sapiens) (aka interleukin 1 beta)
B: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
C: ifn-beta (homo sapiens) (aka interferon beta 1)
D: il-1 (homo sapiens) (aka interleukin 1 beta)
E: interferon alpha 1 (homo sapiens) (aka interferon alpha 1)
F: ifn1@ (ho... | [H; A] |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [il-1 alpha; il-1 beta]
<Options>: A: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
B: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
C: il1a (homo sapiens) (aka interleukin 1 alpha)
D: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
E: interleukin 1 beta (homo sapiens) (aka interleu... | [C; E] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: episodic ataxia, type 7 (homo sapiens) (aka episodic ataxia, type 7)
B: eay (drosophila melanogaster) (early (drosophila melanogaster)) (aka early)
C: aprataxin (sus scrofa) (aka aprataxin)
D: aoeb166 (homo sap... | [F; F; F] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
B: episodic ataxia, type 3 (homo sapiens) (aka episodic ataxia, type 3)
C: aprataxin (sus scrofa) (aka aprataxin)
D: episodic ataxia, type 7 (homo sapiens) (a... | [M; M; M] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: yhae (escherichia coli str. k-12 substr. mg1655) (aka tartronate semialdehyde reductase)
B: aprataxin (drosophila melanogaster) (aka aprataxin)
C: episodic ataxia, type 8 (homo sapiens) (aka episodic ataxia, ty... | [E; E; E] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: episodic ataxia, type 7 (homo sapiens) (aka episodic ataxia, type 7)
B: aprataxin (homo sapiens) (aka aprataxin)
C: aprataxin (mus musculus) (aka aprataxin)
D: episodic ataxia, type 3 (homo sapiens) (aka episod... | [B; B; B] |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaoh; aptx]
<Options>: A: aptx (drosophila melanogaster) (aka aprataxin)
B: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
C: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
D: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
E: e... | [I; I] |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaoh; aptx]
<Options>: A: aptl (homo sapiens) (aka fas ligand)
B: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
C: aptx (xenopus tropicalis) (aka aprataxin)
D: eaoh (homo sapiens) (aka aprataxin)
E: aptx (xenopus laevis) (aka aprataxin l homeolog)
F: etaa1 (homo ... | [D; D] |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaoh; aptx]
<Options>: A: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
B: aptl (homo sapiens) (aka fas ligand)
C: aptx (xenopus laevis) (aka aprataxin l homeolog)
D: etaa1 (homo sapiens) (aka etaa1 activator of atr kinase)
E: eay (drosophila melanogaster) (eyes ... | [I; I] |
<Instruct>: Given the context 'Of the two splicing variants of APTX mRNA, the short and the long forms, long-form APTX mRNA was found to be the major isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [aptx]
<Options>: A: aptx (xenopus laevis) (aka aprataxin l homeolog)
B: aptl (homo sapiens) (aka fas ligand)
C: aptx (xenopus tropicalis) (aka aprataxin)
D: aptx (homo sapiens) (aka aprataxin)
E: apt1 (xenopus laevis) (fas cell surface death receptor s homeolog (xenopus laevis)) (aka fas cell surface death... | [D] |
<Instruct>: Given the context 'Aprataxin is mainly located in the nucleus, and, furthermore, the first nuclear localization signal located near the amino terminus of the long-form aprataxin is essential for its nuclear localization.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [aprataxin]
<Options>: A: aprataxin (homo sapiens) (aka aprataxin)
B: aprataxin (mus musculus) (aka aprataxin)
C: aprataxin (drosophila melanogaster) (aka aprataxin)
D: aprataxin (xenopus tropicalis) (aka aprataxin)
E: aprataxin-like (xenopus laevis) (aka aprataxin-like)
F: None of the above. | [A] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: aprataxin (xenopus tropicalis) (aka aprataxin)
B: xrcc9 (homo sapiens) (aka fa complementation group g)
C: aprataxin (mus musculus) (aka aprataxin)
D: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
E: aprataxin (sus sc... | [H; D; D] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: x-ray repair cross complementing 5 (homo sapiens) (aka x-ray repair cross complementing 5)
B: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 s homeolog (xenopus laevis)) (aka regulator of chromosome condensation 1 s h... | [G; E; E] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: aprataxin (xenopus tropicalis) (aka aprataxin)
B: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 s homeolog (xenopus laevis)) (aka regulator of chromosome condensation 1 s homeolog)
C: xrcc1 (xenopus laevis) (regulato... | [D; K; K] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: polgb (homo sapiens) (aka dna polymerase gamma 2, accessory subunit)
B: dna polymerase beta (homo sapiens) (aka dna polymerase beta)
C: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
D: polynucleotide k... | [K; P; C; B] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: xrcc1 (xenopus tropicalis) (x-ray repair complementing defective repair in chinese hamster cells 1 (xenopus tropicalis)) (aka x-ray repair complementing defective repair in chinese hamster cells 1)
B: polynucleotide k... | [H; I; L; M] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: polynucleotide kinase 3'-phosphatase (homo sapiens) (aka polynucleotide kinase 3'-phosphatase)
B: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 s homeolog (xenopus laevis)) (aka regulator of chromosom... | [H; A; T; D] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: xrcc1 (oryctolagus cuniculus) (aka x-ray repair cross complementing 1)
B: xrcc1 (xenopus tropicalis) (regulator of chromosome condensation 1 (xenopus tropicalis)) (aka regulator of chromosome condensation 1)
C: dna po... | [E; H; N; D] |
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