instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Instead, we propose that the C-terminus of hMre11B participates in protein-protein interaction and functions in a species-specific manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [hmre11b]
<Options>: A: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
B: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
C: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
D: hmr... | [D] |
<Instruct>: Given the context 'Instead, we propose that the C-terminus of hMre11B participates in protein-protein interaction and functions in a species-specific manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [hmre11b]
<Options>: A: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
B: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
C: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
D: or2... | [E] |
<Instruct>: Given the context 'XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [xce]
<Options>: A: xcxcra (xenopus laevis) (aka c-x-c chemokine receptor type a)
B: xct (homo sapiens) (aka solute carrier family 7 member 11)
C: xcel (xenopus tropicalis) (aka carboxyl ester lipase, gene 2)
D: xcca (xenopus laevis) (trna nucleotidyl transferase, cca-adding, 1 s homeolog (xenopus laevis)) ... | [F] |
<Instruct>: Given the context 'The predicted amino-acid sequence of this enzyme, termed XCE, consists of 775 amino-acids with a single putative membrane-spanning region, an N-terminal cytoplasmic domain of 59 residues, and a large luminal domain that contains a characteristic zinc-binding motif.', select the correct bi... | <Mentions>: [xce]
<Options>: A: xcel (xenopus tropicalis) (aka carboxyl ester lipase, gene 2)
B: xcxcra (xenopus laevis) (aka c-x-c chemokine receptor type a)
C: xce (mus musculus) (x chromosome inactivation center (mus musculus)) (aka x chromosome inactivation center)
D: xcca (xenopus laevis) (trna nucleotidyl transfe... | [F] |
<Instruct>: Given the context 'XCE mRNA was found to be predominantly expressed in the central nervous system, sympathetic ganglia and in uterine subepithelial cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [xce]
<Options>: A: xcca (xenopus laevis) (trna nucleotidyl transferase, cca-adding, 1 s homeolog (xenopus laevis)) (aka trna nucleotidyl transferase, cca-adding, 1 s homeolog)
B: xcenp-e (xenopus laevis) (centromere protein e s homeolog (xenopus laevis)) (aka centromere protein e s homeolog)
C: xcel (xenop... | [F] |
<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lysophospholipid-specific lysophospholipase; hlysopla]
<Options>: A: patatin like domain 7, lysophospholipase (homo sapiens) (aka patatin like domain 7, lysophospholipase)
B: splash (homo sapiens) (aka phospholipase a2 group iid)
C: lysophospholipase like 1 (danio rerio) (aka lysophospholipase like 1)
D: s... | [I; I] |
<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lysophospholipid-specific lysophospholipase; hlysopla]
<Options>: A: lysophospholipase 2 l homeolog (xenopus laevis) (aka lysophospholipase 2 l homeolog)
B: spgyla (homo sapiens) (aka deleted in azoospermia like)
C: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
D: lysophospholipase 1... | [G; G] |
<Instruct>: Given the context 'The hLysoPLA hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms, and exhibits apparent cooperativity and surface dilution kinetics, but not interfacial activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing t... | <Mentions>: [hlysopla]
<Options>: A: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
B: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
C: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
D: spgyla (homo sapiens) (aka deleted in azoospermia like)
E: splash (... | [A] |
<Instruct>: Given the context 'Detailed kinetic analysis indicates that the hLysoPLA binds first to the micellar surface and then to the substrate presented on the surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [hlysopla]
<Options>: A: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
B: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
C: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
D: ospl (homo sapiens) (aka claudin 10)
E: lysophospholipase ... | [E] |
<Instruct>: Given the context 'The kinetic parameters associated with this surface dilution kinetic model are reported, and it is concluded that hLysoPLA has a single substrate binding site and a surface recognition site.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [hlysopla]
<Options>: A: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
D: plosl (homo sapiens) (aka transmembrane immune signaling adaptor ty... | [B] |
<Instruct>: Given the context 'The kinetic parameters associated with this surface dilution kinetic model are reported, and it is concluded that hLysoPLA has a single substrate binding site and a surface recognition site.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [hlysopla]
<Options>: A: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
B: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
C: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
D: splash (homo sapiens) (aka phospholipase a2 group iid)
... | [E] |
<Instruct>: Given the context 'In contrast to many non-specific lipolytic enzymes that exhibit lysophospholipase activity, hLysoPLA hydrolyzes only lysophospholipids and has no other significant enzymatic activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [hlysopla]
<Options>: A: spgyla (homo sapiens) (aka deleted in azoospermia like)
B: lysopld (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
C: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
D: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
E: s... | [C] |
<Instruct>: Given the context 'Of special interest, hLysoPLA does not act on plasmenylcholine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hlysopla]
<Options>: A: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
B: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
C: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
D: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase... | [C] |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [syt; brm]
<Options>: A: brms1 like transcriptional repressor (bos taurus) (aka brms1 like transcriptional repressor)
B: syt-vii (homo sapiens) (aka synaptotagmin 7)
C: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
D: synaptotagmin-1 (xenopus tropicalis)... | [K; G] |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [syt; brm]
<Options>: A: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
B: brm (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: synaptoporin (xenopus tropicalis) (aka synaptoporin)
D: syt7 (homo sapiens) (aka synaptotagmin 7)
E: syt1 (homo sapiens) (aka s... | [K; H] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
B: ssxp2 (homo sapiens) (aka ssx family member 6, pseudogene)
C: ssx family member 2 (homo sapiens) (aka ssx family member 2)
D: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
E: ssg1 (xenopus laevis) (coiled-coil do... | [P; M; C] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: ssx family member 2 (homo sapiens) (aka ssx family member 2)
B: structure-specific endonuclease subunit slx1 homolog (caenorhabditis elegans) (aka structure-specific endonuclease subunit slx1 homolog)
C: ssx2 (saccharomyces cerevisiae s288c) (aka rox3p)
D: synaptotagmin-1 (xe... | [P; K; A] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: ssx1 (homo sapiens) (aka ssx family member 1)
B: ssx3 (homo sapiens) (aka ssx family member 3)
C: protein ssuh2 homolog (xenopus laevis) (aka protein ssuh2 homolog)
D: ssx (homo sapiens) (ssx family member 2b (homo sapiens)) (aka ssx family member 2b)
E: synaptoporin (xenopus... | [P; A; O] |
<Instruct>: Given the context 'The SYT protein appears to act as a transcriptional co-activator and the SSX proteins as co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: syt1 (homo sapiens) (aka synaptotagmin 1)
C: syt-vii (homo sapiens) (aka synaptotagmin 7)
D: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
E: syt1 (xenopus tropicalis) (aka syn... | [F] |
<Instruct>: Given the context 'The SYT protein has a novel conserved 54 amino acid domain at the N-terminus of the protein (the SNH domain) which is found in proteins from a wide variety of species, and a C-terminal domain, rich in glutamine, proline, glycine and tyrosine (the QPGY domain), which contains the transcrip... | <Mentions>: [syt]
<Options>: A: syt-vii (homo sapiens) (aka synaptotagmin 7)
B: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
C: syt1 (homo sapiens) (aka synaptotagmin 1)
D: synaptoporin (xenopus tropicalis) (aka synaptoporin)
E: syt (xenopus laevis) (synaptotagmin 1 s ... | [F] |
<Instruct>: Given the context 'The C-terminal SSX domain present in SYT-SSX translocation protein contributes a transcriptional repressor domain to the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [syt]
<Options>: A: syt-vii (homo sapiens) (aka synaptotagmin 7)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
D: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
E: syn (drosophila melanogaster) ... | [F] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: brm (drosophila melanogaster) (aka brahma)
B: snf2h (homo sapiens) (aka snf2 related chromatin remodeling atpase 5)
C: arabidopsis thaliana brahma (arabidopsis thaliana) (aka transcription regulatory protein snf2)
D: syt (xenopus laevis) (synaptotagmin 1 s homeolog (x... | [H; H; H; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: syt (xenopus tropicalis) (aka synaptotagmin 1)
B: smarcf2 (homo sapiens) (aka at-rich interaction domain 1b)
C: synaptoporin (xenopus tropicalis) (aka synaptoporin)
D: brahma (arabidopsis thaliana) (aka transcription regulatory protein snf2)
E: nedesba (homo sapiens) ... | [N; N; N; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: bravo (arabidopsis thaliana) (aka myb domain protein 56)
B: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
C: snf2l2 (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
D: snf7-2 (... | [C; C; C; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
B: nedesba (homo sapiens) (aka trafficking protein particle complex subunit 4)
C: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
D: arabidopsis thaliana bra... | [S; S; S; S] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: brp (mus musculus) (aka growth differentiation factor 5)
B: snf2h (homo sapiens) (aka snf2 related chromatin remodeling atpase 5)
C: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
D: snf2l2 (homo sapiens) (aka swi/snf related baf chromatin remodeling compl... | [D; D; D; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [syt]
<Options>: A: synaptoporin (xenopus tropicalis) (aka synaptoporin)
B: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
C: syt-vii (homo sapiens) (aka synaptotagmin 7)
D: syt (xenopus tropicalis) (aka synaptotagmin 1)
E: syt1 (homo sapiens) (aka synaptotagmin 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'This interaction may provide an explanation of how the SYT protein activates gene transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: syt-vii (homo sapiens) (aka synaptotagmin 7)
D: syt1 (homo sapiens) (aka synaptotagmin 1)
E: syt (xenopus tropicalis) (aka synaptotag... | [F] |
<Instruct>: Given the context 'Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [delta-isoforms of the multifunctional ca2+/calmodulin-dependent protein kinase]
<Options>: A: calcium/calmodulin-dependent protein kinase ii, delta (mus musculus) (aka calcium/calmodulin-dependent protein kinase ii, delta)
B: protein kinase c delta (homo sapiens) (aka protein kinase c delta)
C: calcium/cal... | [E] |
<Instruct>: Given the context 'In this study, we investigated the spectrum of CaMKII isoforms delta2, delta3, delta4, delta8, and delta9 in human striated muscle tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [camkii isoforms delta2, delta3, delta4, delta8, and delta9]
<Options>: A: cki-delta (homo sapiens) (aka casein kinase 1 delta)
B: protein kinase c, delta (mus musculus) (aka protein kinase c, delta)
C: calcium/calmodulin dependent protein kinase ii delta (homo sapiens) (aka calcium/calmodulin dependent pro... | [C] |
<Instruct>: Given the context 'relative to the expression of glyceraldehyde-3-phosphate dehydrogenase in diseased hearts (101. 6+/-11.0% versus 64.9+/-9.9% in the nonfailing group; P < 0.05, n=6).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [glyceraldehyde-3-phosphate dehydrogenase]
<Options>: A: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (homo sapiens) (aka glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)
B: glyceraldehyde-3-phosphate dehydrogenase (xenopus tropicalis) (aka glyceraldehyde-3-phosphate dehydrogenase)
C: gly... | [C] |
<Instruct>: Given the context 'At the protein level, by using a subclass-specific antibody, we observed a similar increase of a delta-CaMKII-specific signal (7.2+/-1.0 versus 3.8+/-0.7 optical density units in the nonfailing group; P < 0.05, n=4 through 6).', select the correct biomedical concept for each mention using... | <Mentions>: [delta-camkii]
<Options>: A: calcium/calmodulin dependent protein kinase ii delta (gallus gallus) (aka calcium/calmodulin dependent protein kinase ii delta)
B: calcium/calmodulin dependent protein kinase (cam kinase) ii delta (xenopus tropicalis) (aka calcium/calmodulin dependent protein kinase (cam kinase)... | [E] |
<Instruct>: Given the context 'At the protein level, by using a subclass-specific antibody, we observed a similar increase of a delta-CaMKII-specific signal (7.2+/-1.0 versus 3.8+/-0.7 optical density units in the nonfailing group; P < 0.05, n=4 through 6).', select the correct biomedical concept for each mention using... | <Mentions>: [delta-camkii]
<Options>: A: camkii (drosophila melanogaster) (aka calcium/calmodulin-dependent protein kinase ii)
B: calcium/calmodulin dependent protein kinase ii delta (gallus gallus) (aka calcium/calmodulin dependent protein kinase ii delta)
C: [d]-camkii (mus musculus) (aka calcium/calmodulin-dependent... | [E] |
<Instruct>: Given the context 'Our data characterize for the first time the delta-CaMKII isoform expression pattern in human hearts and demonstrate changes in this expression pattern in heart failure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [delta-camkii]
<Options>: A: calcium/calmodulin dependent protein kinase (cam kinase) ii delta (xenopus tropicalis) (aka calcium/calmodulin dependent protein kinase (cam kinase) ii delta)
B: calcium/calmodulin dependent protein kinase ii delta (gallus gallus) (aka calcium/calmodulin dependent protein kinase... | [C] |
<Instruct>: Given the context 'Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [insulin receptor related receptor]
<Options>: A: insulin receptor-related receptor (mus musculus) (aka insulin receptor-related receptor)
B: igfir (homo sapiens) (aka insulin like growth factor 1 receptor)
C: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
D: insuli... | [C] |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [insulin receptor related receptor; irr]
<Options>: A: insulin receptor-related receptor (mus musculus) (aka insulin receptor-related receptor)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: insulin receptor related receptor (sus scrofa) (aka insulin receptor related receptor)
D: il1r3 (... | [H; H] |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [insulin receptor related receptor; irr]
<Options>: A: insulin receptor-related receptor (mus musculus) (aka insulin receptor-related receptor)
B: insulin receptor (homo sapiens) (aka insulin receptor)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: insulin receptor related receptor (homo sa... | [D; D] |
<Instruct>: Given the context 'The IRR shares large homology with the insulin and the insulin-like growth factor-1 (IGF-I) receptor with regard to amino acid sequence and protein structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [irr]
<Options>: A: ifnr (homo sapiens) (aka interferon production regulator)
B: insr (homo sapiens) (aka insulin receptor)
C: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: irr (homo sapiens) (aka insulin receptor related receptor)
E: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)... | [D] |
<Instruct>: Given the context 'So far, only a partial human sequence containing the complete 3' end has been reported, although the full-length human IRR cDNA had been used for transfection studies and functional analysis of the receptor.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [irr]
<Options>: A: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: ifnr (homo sapiens) (aka interferon production regulator)
C: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
D: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
E: insulin receptor related receptor (homo sapie... | [E] |
<Instruct>: Given the context 'We have isolated a full-length human IRR cDNA and report on the 5' translated and untranslated region of the human IRR gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [irr]
<Options>: A: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
B: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
C: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
D: insr (homo sapiens) (aka insulin receptor)
E: ifnr (homo sapiens) ... | [B] |
<Instruct>: Given the context 'The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [irr]
<Options>: A: insr (homo sapiens) (aka insulin receptor)
B: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
C: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: ifngr1 (homo sa... | [B] |
<Instruct>: Given the context 'The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [irr]
<Options>: A: insr (homo sapiens) (aka insulin receptor)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
D: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
E: None of the above. | [E] |
<Instruct>: Given the context 'Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [irr]
<Options>: A: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: insrr (homo sapiens) (aka insulin receptor related receptor)
D: insr (homo sapiens) (aka insulin receptor)
E: il1r3 (homo sapiens) (aka interleukin 1 receptor access... | [C] |
<Instruct>: Given the context 'The full length cDNA for the human IRR can now be used for functional expression studies and to elucidate the nature of the ligand for this receptor type.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [irr]
<Options>: A: ifngr (homo sapiens) (aka interferon gamma receptor 1)
B: insr (homo sapiens) (aka insulin receptor)
C: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
D: ifnr (homo sapiens) (aka interferon production regulator)
E: insulin receptor related receptor (homo sapiens) (aka insulin re... | [E] |
<Instruct>: Given the context 'The deduced amino acids sequence shows an overall homology of 48% with the human renal NPT1 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [npt1]
<Options>: A: npt2 (homo sapiens) (aka solute carrier family 34 member 1)
B: solute carrier family 11 member 1 (homo sapiens) (aka solute carrier family 11 member 1)
C: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
D: solute carrier family 1 member 1 (homo sapiens) (aka solute carrier f... | [C] |
<Instruct>: Given the context 'Thus, this gene may code for intestinal type NPT or closely related proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [intestinal type npt]
<Options>: A: npt2 (rattus norvegicus) (aka solute carrier family 34 member 1)
B: npt-1 (homo sapiens) (aka solute carrier family 17 member 1)
C: npt2c (homo sapiens) (aka solute carrier family 34 member 3)
D: nptn-it1 (homo sapiens) (aka nptn intronic transcript 1)
E: nptn (homo sapie... | [F] |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [tgf-beta 1; c-c chemokine receptor 6]
<Options>: A: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: c-c motif chemokine receptor 7 (homo sapiens) (aka c-c motif chemokine receptor 7)
C: il1-beta (homo sapiens) (aka interleukin 1 beta)
D: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine recep... | [F; G] |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [tgf-beta 1; c-c chemokine receptor 6]
<Options>: A: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: interferon beta 1 (homo sapiens) (aka interferon beta 1)
C: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
D: c-x-c motif chemokine receptor 6 (ho... | [I; A] |
<Instruct>: Given the context 'Although CD34+ progenitor-derived immature dendritic cells (DCs) express CCR6, several recent studies reported that monocyte-derived immature DCs do not do so.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [ccr6]
<Options>: A: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
D: None of the above. | [B] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: multi-csf (homo sapiens) (aka interleukin 3)
B: tgfb (homo sapiens) (aka transforming growth factor beta 1)
C: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
D: csf1 (homo sapiens) (aka... | [I; G; B; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: c-c motif chemokine ligand 13 (homo sapiens) (aka c-c motif chemokine ligand 13)
B: interleukin 5 (homo sapiens) (aka interleukin 5)
C: multi-csf (homo sapiens) (aka interleukin 3)
D: interferon beta 1 (homo sapiens) (aka int... | [G; O; R; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: interferon beta 1 (homo sapiens) (aka interferon beta 1)
B: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
C: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
D: tgfb1 (... | [P; L; D; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
B: c-x-c motif chemokine ligand 13 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: csf2 (homo sapiens) (aka colony stimulating factor 2)
D: bolf1 (human gammah... | [C; M; E; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [larc; macrophage inflammatory protein-3 alpha]
<Options>: A: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
B: larc (xenopus tropicalis) (aka c-c motif chemokine ligand 20)
C: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
D: mcp-3 (homo sapiens) (aka c-c motif ... | [A; A] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [larc; macrophage inflammatory protein-3 alpha]
<Options>: A: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
B: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
C: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
D: lncsrlr (homo sapiens) (aka lncr... | [B; B] |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [larc; ccr6]
<Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
C: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
D: larc (homo sapiens) (aka c-c motif chemokin... | [D; E] |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [larc; ccr6]
<Options>: A: lnc-rhl (homo sapiens) (aka lncrna regulator of hepatic lineages 1)
B: lncsrlr (homo sapiens) (aka lncrna sorafenib resistance in renal cell carcinoma associated)
C: ccr6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: lar (homo sapiens) (aka protein tyrosine phosphatase re... | [E; C] |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept for eac... | <Mentions>: [larc; ccr6]
<Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
C: lard (homo sapiens) (aka tnf receptor superfamily member 25)
D: cmkbr6 (homo sapiens) (aka c-c motif chemokine recepto... | [H; D] |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept for eac... | <Mentions>: [larc; ccr6]
<Options>: A: c-c ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
C: larc (xenopus tropicalis) (aka c-c motif chemokine ligand 20)
D: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
E: larc (homo sapiens) (aka c-... | [E; A] |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: prkr (homo sapiens) (aka eukaryotic translation initiation factor 2 alpha kinase 2)
B: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
C: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
D: pkn-alpha (xenopus lae... | [K; F] |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
B: pkn (homo sapiens) (aka protein kinase n1)
C: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
D: pkc-beta (homo sapiens) (aka protein kinase c beta)
E: pkn-alpha (homo... | [K; B] |
<Instruct>: Given the context 'The cDNA clone encoding a novel isoform of protein kinase PKN, termed PKNbeta, was isolated from a HeLa cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta]
<Options>: A: pkn-alpha (homo sapiens) (aka protein kinase n1)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
D: pkc-beta (homo sapiens) (aka protein kinase c beta)
E: pkbb (homo sapiens) (... | [F] |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2),... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkbbeta (homo sapiens) (aka akt serine/threonine kinase 2)
B: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
C: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
D: pkn-alpha (homo sapiens) (aka protein kinas... | [K; G] |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2),... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn2 (homo sapiens) (aka protein kinase n2)
B: pkn1 (homo sapiens) (aka protein kinase n1)
C: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
D: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
E: protein kinase c beta (bos taurus) (aka protein kinase c... | [K; B] |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
B: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
C: pkn2 (homo sapiens) (aka protein kinase n2)
D: pkbbeta (homo sapiens) (aka akt serine/threonine kinase 2)
E: pkn1 (homo sapiens) (a... | [K; E] |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
B: pkn2 (homo sapiens) (aka protein kinase n2)
C: pkbb (homo sapiens) (aka akt serine/threonine kinase 2)
D: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
E: pk... | [K; F] |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn2 (homo sapiens) (aka protein kinase n2)
B: pku-alpha (homo sapiens) (aka tousled like kinase 2)
C: protein kinase c beta (homo sapiens) (aka protein kinase c beta)
D: pkn-alpha (homo sapiens) (aka protein kinase n1)
E: pkn-alpha (xenopus laevis) (aka protein kinase n1 l... | [J; J] |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
B: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
C: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
D: pkgb (homo sapiens) (aka junction plakoglobin)
E: p... | [K; G] |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn (homo sapiens) (aka protein kinase n1)
B: pku-alpha (homo sapiens) (aka tousled like kinase 2)
C: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
D: pkgb (homo sapiens) (aka junction plakoglobin)
E: pkc-beta (homo sapiens) (aka protein kinase c beta)
F: cd... | [K; A] |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: protein kinase c beta (homo sapiens) (aka protein kinase c beta)
B: pkgb (homo sapiens) (aka junction plakoglobin)
C: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
D: protein kinase c, beta (rattus norvegicus) (aka protein... | [J; H] |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
B: pkn-alpha (homo sapiens) (aka protein kinase n1)
C: pku-alpha (homo sapiens) (aka tousled like kinase 2)
D: pkn1 (homo sapiens) (aka protein kinase n1)
E: prkcb (homo sapiens) (aka protein kinase c beta)
F: pkgb (hom... | [K; D] |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [ndp; norrin]
<Options>: A: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
B: naked cuticle homolog 1 (xenopus tropicalis) (aka naked cuticle homolog 1)
C: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
D: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembr... | [I; I] |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [ndp; norrin]
<Options>: A: connectin (rattus norvegicus) (aka titin)
B: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
C: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
D: norp (rattus norvegicus) (aka nucleolin, pseudogene 1)
E: naked cuticle homolog 1 (xenopus tropical... | [I; I] |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [ndp; norrin]
<Options>: A: norrin cystine knot growth factor ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
B: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
C: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
D: naked cuticle homolog 1 (xenopus... | [F; F] |
<Instruct>: Given the context 'Both carried a missense mutation within the NDP gene on chromosome Xp11.2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp]
<Options>: A: ndpkd (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 4)
B: ndpp (homo sapiens) (aka caspase recruitment domain family member 8)
C: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
D: ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
E: naked c... | [D] |
<Instruct>: Given the context 'Subsequently analysis of the retinas of nine enucleated eyes from males with Coats' disease demonstrated in one a somatic mutation in the NDP gene which was not present within non-retinal tissue.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ndp]
<Options>: A: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
B: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
C: ndpkd (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 4)
D: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)... | [E] |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [ndp; norrin]
<Options>: A: ndpp (homo sapiens) (aka caspase recruitment domain family member 8)
B: nor-2 (rattus norvegicus) (aka nuclear receptor subfamily 4, group a, member 3)
C: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
D: ninein-like (rattus norvegicus) (aka ninein-like)
E: ... | [G; G] |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [ndp; norrin]
<Options>: A: nrn (rattus norvegicus) (aka neuritin 1)
B: naked cuticle homolog 1 (xenopus tropicalis) (aka naked cuticle homolog 1)
C: connectin (rattus norvegicus) (aka titin)
D: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
E: nynrin (rattus norvegicus) (aka nyn domai... | [I; I] |
<Instruct>: Given the context 'A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [luteinizing hormone beta-subunit]
<Options>: A: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: follicle stimulating hormone subunit beta (homo sapiens) (aka follicle stimulating... | [A] |
<Instruct>: Given the context 'A common genetic variant (V) of the human luteinizing hormone (LH) beta-subunit gene was recently discovered.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [luteinizing hormone (lh) beta-subunit]
<Options>: A: thyroid stimulating hormone subunit beta (homo sapiens) (aka thyroid stimulating hormone subunit beta)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: lhb (homo sapiens) (chorionic gonadotropin subunit beta 3 (h... | [E] |
<Instruct>: Given the context 'A common genetic variant (V) of the human luteinizing hormone (LH) beta-subunit gene was recently discovered.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [luteinizing hormone (lh) beta-subunit]
<Options>: A: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
B: thyroid stimulating hormone subunit beta (homo sapiens) (aka thyroid stimulating hormone subunit beta)
C: lhb (homo sapiens) (chorionic gonadotropin subunit beta 3 (h... | [E] |
<Instruct>: Given the context 'The V-LH molecules have higher bioactivity in vitro, but shorter half-life in circulation, which apparently is related to the alterations of LH function observed in individuals homo- and heterozygous for the V-LHbeta allele.', select the correct biomedical concept for each mention using t... | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: lutein... | [D] |
<Instruct>: Given the context 'We have now studied whether additional mutations in the V-LHbeta promoter sequence could contribute to the altered physiology of the LH variant molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizin... | [C] |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
C: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: lutropin subunit beta-like (xenopus lae... | [C] |
<Instruct>: Given the context 'Reporter constructs with various lengths of the wt- and V-LH promoter sequences, driving the firefly luciferase reporter gene, were transfected into an immortalized mouse pituitary cell line, LbetaT(2), known to express the endogenous LHbeta gene, and into a non-endocrine human embryonic ... | <Mentions>: [lhbeta]
<Options>: A: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
C: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
D: luteinizing hormone subunit beta (oryctolagus cuniculus... | [A] |
<Instruct>: Given the context 'Basal expression levels of the V-LHbeta promoter constructs were on average 36% higher in LbetaT(2)cells ( P < 0.001; n = 29), and 40% higher in HEK 293 cells ( P < 0.001; n = 16), as compared with the respective wt sequences.', select the correct biomedical concept for each mention using... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: ... | [B] |
<Instruct>: Given the context 'Numerous qualitative and quantitative differences were found between the two cell lines in responses of the two promoter sequences to stimulation with 12- O -tetradecanoylphorbol-13-acetate, forskolin, 8-bromo-cAMP, progesterone and gonado- tropin-releasing hormone.', select the correct b... | <Mentions>: [gonado- tropin-releasing hormone]
<Options>: A: hypocretin (orexin) neuropeptide precursor (xenopus tropicalis) (aka hypocretin (orexin) neuropeptide precursor)
B: growth hormone releasing hormone (homo sapiens) (aka growth hormone releasing hormone)
C: lhrh (homo sapiens) (aka gonadotropin releasing hormo... | [C] |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
D: luteinizing horm... | [B] |
<Instruct>: Given the context 'The altered promoter function of the V-LHbeta gene provides evidence for differences in regulation of the wt- and V-LHbeta genes, which may contribute to the differences observed in pituitary-gonadal function between carriers of the two LHbeta alleles.', select the correct biomedical conc... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
D: lutropin s... | [E] |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hydroxypyruvate reductase; grhpr]
<Options>: A: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
B: hydroxypyruvate reductase 3 (arabidopsis thaliana) (aka d-isomer specific 2-hydroxyacid dehydrogenase family protein)
C: grhr (homo sapiens) (aka gonadot... | [A; A] |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hydroxypyruvate reductase; grhpr]
<Options>: A: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
B: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
C: grhpr (xenopus tropicalis) (glyoxylate reductase/hydr... | [I; I] |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hydroxypyruvate reductase; grhpr]
<Options>: A: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
B: glyoxylate and hydroxypyruvate reductase (rattus norvegicus) (aka glyoxylate and hydroxypyruvate reductase)
C: hdhpr (homo sapiens) (aka quinoid dihydrop... | [A; A] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: grhpr (xenopus tropicalis) (glyoxylate reductase/hydroxypyruvate reductase, gene 1 (xenopus tropicalis)) (aka glyoxylate reductase/hydroxypyruvate reductase, gene 1)
B: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1... | [D; D; D] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: grhr (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: hydroxypyruvate reductase (arabidopsis thaliana) (aka hydroxypyruvate reductase)
C: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate red... | [G; G; G] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: glyoxylate/succinic semialdehyde reductase 1 (glycine max) (aka glyoxylate/succinic semialdehyde reductase 1)
B: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
C: prolactin releasing hormone receptor (homo sapiens) (aka pro... | [K; K; K] |
<Instruct>: Given the context 'Transient transfection of the cDNA clone into COS cells verified that it encoded an enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [glyoxylate reductase]
<Options>: A: glyoxylate reductase 1 homolog (bos taurus) (aka glyoxylate reductase 1 homolog)
B: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
C: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate ... | [B] |
<Instruct>: Given the context 'The genomic structure of the human GRHPR gene was determined and contains nine exons and eight introns and spans approximately 9 kb pericentromeric on chromosome 9.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [grhpr]
<Options>: A: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
B: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
C: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
D: grpr (hom... | [A] |
<Instruct>: Given the context 'Four PH2 patients representing two pairs of siblings from two unrelated families were analyzed for mutations in GRHPR by single strand conformation polymorphism analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [grhpr]
<Options>: A: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
B: grr1 (glycine max) (aka putative ein3-binding f-box protein)
C: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
D: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing h... | [C] |
<Instruct>: Given the context 'The cDNA that we have identified represents the first characterization of an animal GRHPR sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [grhpr]
<Options>: A: grr1 (glycine max) (aka putative ein3-binding f-box protein)
B: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
C: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
D: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c ... | [E] |
<Instruct>: Given the context 'Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells.
', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
B: ectodysplasin a (bos taurus) (aka ectodysplasin a)
C: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
D: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
E: ectodysplasin a rec... | [C] |
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