instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodermal dysplasia; eda]
<Options>: A: ectodermal dysplasia 5, hair/nail type (homo sapiens) (aka ectodermal dysplasia 5, hair/nail type)
B: eda1r (homo sapiens) (aka ectodysplasin a receptor)
C: edd (arabidopsis thaliana) (aka glycine-trna ligase)
D: asphixiating thoracic dystrophy (chondroectodermal dy... | [F; F] |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodermal dysplasia; eda]
<Options>: A: eed (homo sapiens) (aka embryonic ectoderm development)
B: eda3 (homo sapiens) (ectodysplasin a receptor (homo sapiens)) (aka ectodysplasin a receptor)
C: ectds (homo sapiens) (aka grainyhead like transcription factor 2)
D: ectrodactyly, ectodermal dysplasia and cle... | [F; F] |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodermal dysplasia; eda]
<Options>: A: eed (homo sapiens) (aka embryonic ectoderm development)
B: ectodermal dysplasia 8, hair/tooth/nail type (homo sapiens) (aka ectodermal dysplasia 8, hair/tooth/nail type)
C: edd (arabidopsis thaliana) (aka glycine-trna ligase)
D: ectds (homo sapiens) (aka grainyhead ... | [J; J] |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eda; ectodysplasin]
<Options>: A: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
B: ectodysplasin a (danio rerio) (aka ectodysplasin a)
C: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
D: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s... | [E; E] |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eda; ectodysplasin]
<Options>: A: edd (arabidopsis thaliana) (aka glycine-trna ligase)
B: ectodysplasin a (bos taurus) (aka ectodysplasin a)
C: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
D: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodyspla... | [I; I] |
<Instruct>: Given the context 'In order to understand better the function of the ectodysplasin protein molecule and its domains, we have studied the processing and localization of wild-type and mutated isoforms in transfected human fetal kidney 293 and monkey kidney COS-1 cells.', select the correct biomedical concept ... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
B: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a (bos taurus) (aka ectodysplasin a)
E: hed (homo sapiens) (ectodys... | [E] |
<Instruct>: Given the context 'Similar to other members of collagenous membrane proteins and members of TNF-related ligands, ectodysplasin is a type II membrane protein and it forms trimers.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
B: ectodysplasin a (bos taurus) (aka ectodysplasin a)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
E: ectd1 (homo sapiens) (ectodysplas... | [E] |
<Instruct>: Given the context 'The membrane localization of ectodysplasin is asymmetrical: it is found on the apical and lateral surfaces of the cells where it co-localizes with cytoskeletal structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
B: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a (bos taurus) (aka ectodysplasin a)
E: hed (homo sapiens) (ectodysplasin a... | [E] |
<Instruct>: Given the context 'Our results suggest that ectodysplasin is a new member in the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
B: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a (bos taurus) (aka ectodysplasin a)
E: ectodysplasin a (sus scrofa) (... | [B] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [bis; bcl-2]
<Options>: A: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
B: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
C: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
D: bcl2 interacting protein... | [K; A] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [bis; bcl-2]
<Options>: A: bcl2l (homo sapiens) (aka bcl2 like 1)
B: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
D: bcl-b (homo sapiens) (aka bcl2 like 10)
E: bisb (escherichia coli str. k-12 substr. mg1... | [J; J] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [bis; bcl-2]
<Options>: A: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: bcl2l2 (homo sapiens) (aka bcl2 like 2)
C: bcl2l (homo sapiens) (aka bcl2 like 1)
D: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
E: bisc (drosophila melanogaster) (aka biscotti... | [K; J] |
<Instruct>: Given the context 'Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [bis]
<Options>: A: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
B: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: bis (mus musculus) (aka bcl2-associated athanogene 3... | [F] |
<Instruct>: Given the context 'Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis]
<Options>: A: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
B: bisc (drosophila melanogaster) (aka biscotti)
C: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
D: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
E: bis (dro... | [F] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: ccnb2 (homo sapiens) (aka cyclin b2)
B: bcl2 like 2 (homo sapiens) (aka bcl2 like 2)
C: bis (mus musculus) (aka bcl2-associated athanogene 3)
D: bcl-b (homo sapiens) (aka bcl2 like 10)
E: bis (drosophila melanogaster) (aka bistre)
F: bcl2 apoptosis regulator (homo sapiens) (aka bc... | [K; F] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bis (mus musculus) (aka bcl2-associated athanogene 3)
B: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
C: bcl2l (homo sapiens) (aka bcl2 like 1)
D: bisc (drosophila melanogaster) (aka biscotti)
E: bis (drosophila melanogaster) (aka bistre)
F: bisb (esc... | [K; G] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: bis (mus musculus) (aka bcl2-associated athanogene 3)
C: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
D: bak2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
E: bcl2l (homo sapiens) (aka bcl2 like 1)
F: f... | [U; C; P; M] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fas-as (homo sapiens) (aka fas antisense rna 1)
B: bax (escherichia coli str. k-12 substr. mg1655) (aka putative glycoside hydrolase bax)
C: bcl2l2 (homo sapiens) (aka bcl2 like 2)
D: bak (homo sapiens) (aka bcl2 antagonist/killer 1)
E: bak2 (homo sapiens) (aka bcl2 anta... | [T; Q; R; L] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bcl-x (homo sapiens) (aka bcl2 like 1)
B: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
C: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
D: bcl-b (homo sapiens) (aka bcl2 like 10)
E:... | [U; I; B; M] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fasps (homo sapiens) (aka period circadian regulator 2)
B: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
C: bcl-x (homo sapiens) (aka bcl2 like 1)
D: bax (escherichia coli str. k-12 substr. mg1655) (aka putative glycoside hydrola... | [T; O; F; T] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bis (drosophila melanogaster) (aka bistre)
B: bax (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
C: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
D: bcl2 (homo sapiens) (aka bcl2 apoptosis regulator)
E: fas cell surface death recepto... | [U; D; B; E] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [bis; bcl-2]
<Options>: A: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
B: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
C: bcl2l (homo sapiens) (aka bcl2 like 1)
D: bisc (drosophila melanogaster) (aka biscotti)
E: bis (mus musculus) (aka b... | [K; B] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [bis; bcl-2]
<Options>: A: bisc (drosophila melanogaster) (aka biscotti)
B: bcl2l (homo sapiens) (aka bcl2 like 1)
C: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
D: bcl2l2 (homo sapiens) (aka bcl2 like 2)
E: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
F: bis1 (homo... | [K; H] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Mentions>: [bcar1; p130cas]
<Options>: A: p120cas (homo sapiens) (aka catenin delta 1)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: p130cas (sus scrofa) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: p120cas (xenop... | [D; D] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Mentions>: [bcar1; p130cas]
<Options>: A: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: p130cas (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: p120cas (xenopus tro... | [I; I] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Mentions>: [bcar1; p130cas]
<Options>: A: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
B: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas fam... | [B; B] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: breast cancer associated esr1 regulating natural antisense transcript 1 (homo sapiens) (aka breast cancer associated esr1 regulating natural antisense transcript 1)
B: bcar3 antisense rna 1 (homo sapiens) (aka bcar3 antisense rna 1)
C: bcar1 sca... | [C; C] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: breast cancer anti-estrogen resistance 4 (homo sapiens) (aka breast cancer a... | [A; A] |
<Instruct>: Given the context 'Transfer of the BCAR1 locus from retrovirus-mutated, antiestrogen-resistant cells to estrogen-dependent ZR-75-1 cells by cell fusion conferred an antiestrogen-resistant phenotype on the recipient cells.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [bcar1]
<Options>: A: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
B: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: bcar1 (bos taurus) (aka bcar1 scaffold protein... | [C] |
<Instruct>: Given the context 'The complete coding sequence of BCAR1 was isolated by use of exon-trapping and complementary DNA (cDNA) library screening.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcar1]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
E: bcar1 (xenopus tropicali... | [B] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: p130cas (drosophila melanogaster) (aka p130cas)
B: p130cas (sus scrofa) (aka bcar1 scaffold protein, cas family member)
C: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: p130cas (xenopus tropicalis) (... | [C; G] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: p130cas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: p130cas (xenopus tr... | [I; J] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: dcas (drosophila melanogaster) (p130cas (drosophila melanogaster)) (aka p130cas)
C: p120cas (homo sapiens) (aka catenin delta 1)
D: p130cas (xenopus tropicalis) (aka bcar1, cas family scaffold pr... | [J; F] |
<Instruct>: Given the context 'Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
E: bcar1 scaffold prot... | [C] |
<Instruct>: Given the context 'BCAR1 transcripts were detected in multiple human tissues and were similar in size to transcripts produced by retrovirus-mutated ZR-75-1 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [bcar1]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: bcar1 ... | [A] |
<Instruct>: Given the context 'Transfection of BCAR1 cDNA into ZR-75-1 cells again resulted in sustained cell proliferation in the presence of antiestrogens, confirming that BCAR1 was the responsible gene in the locus.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [bcar1]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 ... | [B] |
<Instruct>: Given the context 'Overexpression of the BCAR1 gene confers antiestrogen resistance on human ZR-75-1 breast cancer cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, ca... | [D] |
<Instruct>: Given the context 'Overexpression of BCAR1 in retrovirus-mutated cells appears to result from activation of the gene's promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas fami... | [E] |
<Instruct>: Given the context 'Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [langerin]
<Options>: A: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
B: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
C: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
D: cd207 molecule (homo sapiens) (ak... | [D] |
<Instruct>: Given the context 'We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [langerin]
<Options>: A: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
B: cd207 (homo sapiens) (aka cd207 molecule)
C: cd206 (homo sapiens) (aka mannose receptor c-type 1)
D: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
E: cd209 antigen-like protein a (xenopus tropicalis) (clec9a ... | [B] |
<Instruct>: Given the context 'Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [langerin]
<Options>: A: cd207 molecule (homo sapiens) (aka cd207 molecule)
B: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
C: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
D: cd20l (homo sapiens) (aka membrane spann... | [A] |
<Instruct>: Given the context 'Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [langerin]
<Options>: A: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
B: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
C: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
D: cd20-like (xenopus tropicalis) (aka membr... | [E] |
<Instruct>: Given the context 'Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [langerin]
<Options>: A: cd206 (homo sapiens) (aka mannose receptor c-type 1)
B: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
C: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
D: cd207 (homo sapiens) (aka cd207 molecule)
E: cd209 antigen-like protein a (xenopus tropicalis... | [D] |
<Instruct>: Given the context 'Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd207 (homo sapiens) (aka cd207 molecule)
D: cd20l7 (homo sapiens) (aka membrane spanning 4-do... | [C] |
<Instruct>: Given the context 'Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [langerin]
<Options>: A: cd206 (homo sapiens) (aka mannose receptor c-type 1)
B: cd207 molecule (homo sapiens) (aka cd207 molecule)
C: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
D: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
E: cd209 antigen-like protein a (xenopus tro... | [B] |
<Instruct>: Given the context 'Cloning and characterisation of the Sry-related transcription factor gene Sox8.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (sus scrofa) (aka sry-box transcription factor 8)
B: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
C: sry-box 8 (gallus gallus) (aka sry-box 8)
D: sox8 (homo sapiens) (aka sry-box transcription factor 8)
E: sox8 (danio ... | [D] |
<Instruct>: Given the context 'We report here the isolation of Sox8 and its characterisation in mice and humans.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (homo sapiens) (aka sry-box transcription factor 8)
B: sox8 (danio rerio) (aka sry-box transcription factor 8b)
C: sox8 (sus scrofa) (aka sry-box transcription factor 8)
D: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
E: sry-box 8 (gallus gallus) (aka sry-box 8)
F: None of the ... | [A] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [sox9; sox10]
<Options>: A: sox9 (gallus gallus) (aka sry-box 9)
B: sox10 (xenopus tropicalis) (aka sry-box 10)
C: sox10 (homo sapiens) (aka sry-box transcription factor 10)
D: sox-10 (gallus gallus) (aka sry-box 10)
E: sox10 (xenopus laevis) (aka sry-box 10 l homeolog)
F: sry-box transcription factor 10 (d... | [J; C] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [sox9; sox10]
<Options>: A: sox9 (xenopus tropicalis) (aka sry-box 9)
B: sox9 promoter region (homo sapiens) (aka sox9 promoter region)
C: bobby sox homolog (xenopus tropicalis) (aka bobby sox homolog)
D: sox9 (homo sapiens) (aka sry-box transcription factor 9)
E: sox9 (xenopus laevis) (sry-box 9 l homeolog... | [D; J] |
<Instruct>: Given the context 'SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans -activation regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [sox8]
<Options>: A: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
B: sox8 (danio rerio) (aka sry-box transcription factor 8b)
C: sox8 (xenopus tropicalis) (aka sry-box 8)
D: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
E: sry-box transcription factor 8 (homo sapiens) (aka sry-box trans... | [E] |
<Instruct>: Given the context 'SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans -activation regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [sox8]
<Options>: A: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
B: sox8 (xenopus tropicalis) (aka sry-box 8)
C: sox8 (danio rerio) (aka sry-box transcription factor 8b)
D: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'Further, Sox8 is expressed in the central nervous system, limbs, kidneys, gonads and craniofacial structures during mouse embryo development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [sox8]
<Options>: A: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
B: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
C: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
D: sox8 (xenopus laevis) (... | [B] |
<Instruct>: Given the context 'Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13.3, a region associated with the microphthalmia-cataract syndrome CATM and the alpha-thalassemia/mental retardation syndrome ATR-16.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [sox8]
<Options>: A: sox8 (sus scrofa) (aka sry-box transcription factor 8)
B: sry-box 8 (gallus gallus) (aka sry-box 8)
C: sox8 (danio rerio) (aka sry-box transcription factor 8b)
D: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
E: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription... | [E] |
<Instruct>: Given the context 'Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (homo sapiens) (aka syntaphilin)
B: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
C: syntaphilin (bos taurus) (aka syntaphilin)
D: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
E: syntaphilin (sus scrofa) (aka syntaphilin)
F: None of... | [A] |
<Instruct>: Given the context 'Syntaxin-1 is a key component of the synaptic vesicle docking/fusion machinery that forms the SNARE complex with VAMP/synaptobrevin and SNAP-25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [snap-25]
<Options>: A: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25kda s homeolog)
B: snap25 (drosophila melanogaster) (aka synaptosomal-associated protein 25kda)
C: snap25 (sus scrofa) (aka synaptosome associated protein... | [E] |
<Instruct>: Given the context 'We have cloned and characterized a protein called syntaphilin that is selectively expressed in brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (homo sapiens) (aka syntaphilin)
B: syntaphilin (sus scrofa) (aka syntaphilin)
C: syntaphilin (rattus norvegicus) (aka syntaphilin)
D: syntaphilin (bos taurus) (aka syntaphilin)
E: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
F: None of the above. | [A] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [syntaphilin; snap-25]
<Options>: A: snap25 (sus scrofa) (aka synaptosome associated protein 25)
B: syntaphilin (xenopus tropicalis) (aka syntaphilin)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: snap-25 (bos taurus) (aka synaptosome associated protein 25)
E: snap25 (homo sapiens) (aka synaptosome ass... | [C; E] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [syntaphilin; snap-25]
<Options>: A: syntaphilin (sus scrofa) (aka syntaphilin)
B: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25kda s homeolog)
C: syntaphilin (rattus norvegicus) (aka syntaphilin)
D: syn1 (drosophila melano... | [I; E] |
<Instruct>: Given the context 'Transient overexpression of syntaphilin in cultured hippocampal neurons significantly reduces neurotransmitter release.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syntaphilin (bos taurus) (aka syntaphilin)
C: syn (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syntaphilin (xenopus laevis) ... | [D] |
<Instruct>: Given the context 'Transient overexpression of syntaphilin in cultured hippocampal neurons significantly reduces neurotransmitter release.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
B: syntaphilin (bos taurus) (aka syntaphilin)
C: syn (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
D: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
E: None of the abov... | [E] |
<Instruct>: Given the context 'Furthermore, introduction of syntaphilin into presynaptic superior cervical ganglion neurons in culture inhibits synaptic transmission.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [syntaphilin]
<Options>: A: syn (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
B: syntaphilin (homo sapiens) (aka syntaphilin)
C: syntaphilin (xenopus tropicalis) (aka syntaphilin)
D: syntaphilin (rattus norvegicus) (aka syntaphilin)
E: syn1 (drosophila melanogaster) (syntroph... | [B] |
<Instruct>: Given the context 'These findings suggest that syntaphilin may function as a molecular clamp that controls free syntaxin-1 availability for the assembly of the SNARE complex, and thereby regulates synaptic vesicle exocytosis.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [syntaphilin]
<Options>: A: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
B: syntaphilin (xenopus tropicalis) (aka syntaphilin)
C: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
D: syn1 (drosophila melanogaster) (synapsin (drosophila melanoga... | [E] |
<Instruct>: Given the context 'Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [human follicle stimulating hormone receptor]
<Options>: A: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
C: fshrg1 (homo sapiens) (aka bromodomain conta... | [B] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for ea... | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
B: ghr (homo sapiens) (aka growth hormone receptor)
C: follicle stimulating hormone receptor (oryctolagus cuniculus) (aka follicle stimulating hormone ... | [D; D] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for ea... | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: follicle stimulating hormone receptor (rattus norvegicus) (aka follicle stimulating hormone receptor)
B: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
C: follicle stimulating hormone receptor (oryc... | [F; F] |
<Instruct>: Given the context 'Epitope mapping using synthetic peptides, and truncated hFSH-R variants revealed that mAb 106.156 bound to ECD residues 183-220, while mAbs 106.318, 106.290, 106.263 bound ECD residues 300-331.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [hfsh-r]
<Options>: A: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: ghr (homo sapiens) (aka growth hormone receptor)
C: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
D: fshr (homo sapiens) (aka follicle stimulating hormone receptor)... | [D] |
<Instruct>: Given the context 'Immunofluorescence microscopy showed that mAbs 106.318 and 106.156 stained the surface of fixed, intact CHO cells expressing wild type hFSH-R. However, following cell permeabilization all four antibodies stained hFSH-R in Golgi and endoplasmic reticulum.', select the correct biomedical co... | <Mentions>: [hfsh-r]
<Options>: A: ghrfr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
... | [E] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: sialic acid acetylesterase (homo sapiens) (aka sialic acid acetylesterase)
C: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
D: neuraminidase 2 ... | [F; G] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: neuraminidase 3 (homo sapiens) (aka neuraminidase 3)
B: neuraminidase 2 (homo sapiens) (aka neuraminidase 2)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
E: gr... | [J; H] |
<Instruct>: Given the context 'Thus truncated hFSH-R variants do not reach the medial or trans Golgi where high mannose oligosaccharides are trimmed and sialic acid is added.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [hfsh-r]
<Options>: A: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
B: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
C: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
D: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasin... | [E] |
<Instruct>: Given the context 'The pro-alpha3(V) collagen chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v) collagen]
<Options>: A: col5a3.s (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
D: collagen type v alpha 3 chain (... | [B] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of cl... | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
D: collagen type v alpha 2 chain (gallus gallus... | [I; F] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of cl... | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
B: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
C: vla5a (homo sapiens) (aka integrin subunit alpha 5)
D: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha... | [F; I] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla5a (homo sapiens) (aka integrin subunit alpha 5)
B: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
C: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
D: integrin subunit alpha v (homo sapie... | [K; C; J] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
D: vla-2 (homo sapiens) (aka integr... | [A; F; K] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
B: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
C: vla3a (homo sapiens) (aka integrin subunit alpha 3)
D: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha... | [F; D; K] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [pro-alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
C: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
D: collagen type v alpha 3 chai... | [A] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
D: apoa-v (xenopus tr... | [G; E; E] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: apoa-v (rattus norvegicus) (aka apolipoprotein a5)
B: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
C: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
D: integrin subunit alp... | [J; I; I] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: procollagen, type v, alpha 1 (danio rerio) (aka procollagen, type v, alpha 1)
D: collagen type xv alpha 1 c... | [I; M; M] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
C: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
D: collagen type... | [C; E] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
C: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
D: collagen typ... | [F; I] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
B: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
C: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
D: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
E: c... | [F; J] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
B: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
C: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
D: collagen type v alpha 2 chain (... | [L; F; A] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: vla5a (homo sapiens) (aka integrin subunit alpha 5)
B: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
D: integrin subunit alpha v (h... | [N; E; G] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
B: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
C: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
D: vla5a (homo sapiens) (aka integrin subunit alpha 5)... | [F; I; M] |
<Instruct>: Given the context 'In situ hybridization of mouse embryos detects alpha3(V) expression primarily in the epimysial sheaths of developing muscles and within nascent ligaments adjacent to forming bones and in joints.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [alpha3(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
C: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
D: collagen type v alpha 3 ch... | [F] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
B: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
C: collagen type v alpha 1 chain (rattus norvegicus) (aka collagen type v alpha 1 chain)
D: collagen type v alpha 3 chain (h... | [L; A; D] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla5a (homo sapiens) (aka integrin subunit alpha 5)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
D: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v ... | [D; E; M] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
D: collagen type v alpha 2 chain (rattus norvegicu... | [K; N; A] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
B: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
C: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
D: collagen type vi alpha 2 ... | [J; G; E] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: col5a1 (homo sapiens) (aka collagen type v alpha 1 chain)
B: col4a5 (homo sapiens) (aka collagen type iv alpha 5 chain)
C: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
D: vla-5 (homo sapiens) (aka integrin subunit alpha 5)
... | [J; F; G] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: col4a3 (homo sapiens) (aka collagen type iv alpha 3 chain)
C: col4a5 (homo sapiens) (aka collagen type iv alpha 5 chain)
D: collagen type v alpha 2 chain (gallus gallus) (aka collagen type ... | [J; I; L] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
B: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
C: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
D: collagen type v alpha 2 chain (homo sapi... | [O; K; D] |
<Instruct>: Given the context 'COL5A3 is mapped to 19p13.2 near a polymorphic marker that should be useful in analyzing linkage with EDS and other disease phenotypes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [col5a3]
<Options>: A: col5a1 (homo sapiens) (aka collagen type v alpha 1 chain)
B: col5a2 (homo sapiens) (aka collagen type v alpha 2 chain)
C: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
D: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
E: col5a3.s (xenopus la... | [D] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [mdm2; p53]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
D: mdm1 (homo sapiens) (aka mdm1 nucl... | [E; H] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [mdm2; p53]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
C: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
D: ct53 (homo sapiens) (aka zin... | [H; E] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [p53]
<Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: trp53 (homo sapiens) (aka tumor protein p53)
C: ct53 (homo sapiens) (aka zinc finger protein 165)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: p53cp (homo sapiens) (aka tumor prot... | [B] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [mdm2; p53]
<Options>: A: mdm2bp (homo sapiens) (aka mdm2 binding protein)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: tp73 (homo sapiens) (aka tumor protein p73)
D: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
E: p532 (homo sapiens) (aka hect and rld domain cont... | [D; J] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [mdm2; p53]
<Options>: A: tp53 (homo sapiens) (aka tumor protein p53)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: rad53 (homo sapiens) (aka checkpoint kinase 2)
E: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm... | [G; A] |
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