instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [mdm2; p53]
<Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 onco... | [J; I] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the ... | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: ubiquitin like modifier activating enzyme 1 (homo sapiens) (aka ubiquitin like modifier activating enzyme 1)
B: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
C: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
D: mdm2, transformed 3t3 cel... | [G; H] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the ... | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: ubiquitin like modifier activating enzyme 7 (homo sapiens) (aka ubiquitin like modifier activating enzyme 7)
B: ubiquitin like modifier activating enzyme 1 (xenopus tropicalis) (aka ubiquitin like modifier activating enzyme 1)
C: ubiquitin-like modifier... | [I; A] |
<Instruct>: Given the context 'It is apparent, therefore, that Mdm2 manifests an intrinsic capacity to mediate ubiquitination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
C: mdm2bp (homo sapiens) (aka mdm2 binding protein)
D: mdm2 proto-oncogene (homo sapiens) (aka... | [D] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [p53; mdm2]
<Options>: A: tumor protein p73 (homo sapiens) (aka tumor protein p73)
B: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
C: tp53 (homo sapiens) (aka tumor protein p53)
D: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
E: ct53 (homo sapiens) (aka zinc finger ... | [C; F] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [p53; mdm2]
<Options>: A: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
B: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
C: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: mdm1 (homo ... | [F; B] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mdm2; praja1]
<Options>: A: mdm2 proto-oncogene (homo sapiens) (aka mdm2 proto-oncogene)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: praja1 (homo sapiens) (aka praja ring finger ubiquitin ligase 1)
D: praja ring fing... | [A; C] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mdm2; praja1]
<Options>: A: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
B: keratin associated protein 1-1 (homo sapiens) (aka keratin associated protein 1-1)
C: mdm2, transformed 3t3 cell double minute p53 binding protein ... | [J; I] |
<Instruct>: Given the context 'However, this RING was ineffective in ubiquitination and proteasomal targeting of p53, suggesting that there may be specificity at the level of the RING in the recognition of heterologous substrates.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [p53]
<Options>: A: ct53 (homo sapiens) (aka zinc finger protein 165)
B: p53 (homo sapiens) (aka tumor protein p53)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: p53cp (homo sapiens) (aka tumor protein p63)
E: tumor protein p73 (homo sapiens) (aka tumor protein p73)
F: None of the above. | [B] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: podocalyxin like (bos taurus) (aka podocalyxin like)
B: betaglycan (homo sapiens) (aka transforming growth factor beta receptor 3)
C: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
D: cd34 molecule (homo sapiens) (aka cd34 molecule)
E: cd114 (homo... | [I; D; O] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: podocalyxin like (xenopus tropicalis) (aka podocalyxin like)
B: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
C: cd344 (homo sapiens) (aka frizzled class receptor 4)
D: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
... | [H; B; I] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: endoglin (homo sapiens) (aka endoglin)
B: podocalyxin like (oryctolagus cuniculus) (aka podocalyxin like)
C: cd34 (gallus gallus) (aka cd34 molecule)
D: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
E: cd114 (homo sapiens) (aka colony stimu... | [K; M; O] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: podocalyxin-like (rattus norvegicus) (aka podocalyxin-like)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
D: endoglin (sus scrofa) (aka en... | [L; G; K] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [podocalyxin]
<Options>: A: podocalyxin like (homo sapiens) (aka podocalyxin like)
B: podocalyxin-like (rattus norvegicus) (aka podocalyxin-like)
C: podocalyxin like (bos taurus) (aka podocalyxin like)
D: podocalyxin like (gallus gallus) (aka podocalyxin like)
E: podocalyxin like (oryctolagus cuniculus) (ak... | [A] |
<Instruct>: Given the context 'Using homologies present in the cytoplasmic tails of these proteins, we have identified a novel member of this family, which we designate endoglycan.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [endoglycan]
<Options>: A: betaglycan (homo sapiens) (aka transforming growth factor beta receptor 3)
B: eg (homo sapiens) (aka podocalyxin like 2)
C: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
D: endomucin (homo sapiens) (aka endomucin)
E: matrix extracellular phosphoglycoprotein (ho... | [B] |
<Instruct>: Given the context 'In addition, endoglycan contains several potential glycosaminoglycan attachment sites and is modified with chondroitin sulfate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [endoglycan]
<Options>: A: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
B: eg (homo sapiens) (aka podocalyxin like 2)
C: endomucin (homo sapiens) (aka endomucin)
D: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
E: matrix extracellular phosphoglycoprotein (homo sapi... | [B] |
<Instruct>: Given the context 'Endoglycan mRNA and protein were detected in both endothelial cells and CD34(+) bone marrow cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [endoglycan]
<Options>: A: endoglin (sus scrofa) (aka endoglin)
B: endoglin (homo sapiens) (aka endoglin)
C: eg (homo sapiens) (aka podocalyxin like 2)
D: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
E: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular ph... | [C] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: podocalyxin like (homo sapiens) (aka podocalyxin like)
B: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
C: podocalyxin like 2 (homo sapiens) (aka podocalyxin like 2)
D: bgcan (homo sapiens) (aka transforming growth factor beta receptor 3... | [B; A; L] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: podocalyxin-like (rattus norvegicus) (aka podocalyxin-like)
B: bgcan (homo sapiens) (aka transforming growth factor beta receptor 3)
C: cd34 (sus scrofa) (aka cd34 molecule)
D: podocalyxin like 2 (homo sapiens) (aka podocalyxin like 2)
E: endoglin (sus scrofa) (... | [G; H; O] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: fat4 (homo sapiens) (aka fat atypical cadherin 4)
B: endoglin (sus scrofa) (aka endoglin)
C: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
D: podocalyxin like (homo sapiens) (aka podocalyxin like)
E: cd34 (homo sapiens) (cd34 molecule (homo s... | [E; D; I] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: eg (homo sapiens) (aka podocalyxin like 2)
B: cd34 (sus scrofa) (aka cd34 molecule)
C: endomucin (homo sapiens) (aka endomucin)
D: podocalyxin-like (homo sapiens) (aka podocalyxin-like)
E: cd34 molecule (homo sapiens) (aka cd34 molecule)
F: podocalyxin like (gal... | [E; N; A] |
<Instruct>: Given the context 'While the members of this family may perform overlapping functions at these sites, the unique structural features of endoglycan suggest distinct functions for this molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [endoglycan]
<Options>: A: eg (homo sapiens) (aka podocalyxin like 2)
B: endomucin (homo sapiens) (aka endomucin)
C: endoglin (sus scrofa) (aka endoglin)
D: endoglin (homo sapiens) (aka endoglin)
E: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [8d6; 8d6 antigen (ag)]
<Options>: A: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
B: tspan-6 (homo sapiens) (aka tetraspanin 6)
C: d6 (homo sapiens) (aka atypical chemokine receptor 2)
D: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
E: 8d6 (mus musculus) (aka cd320 ant... | [F; F] |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [8d6; 8d6 antigen (ag)]
<Options>: A: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
B: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
C: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
D: 8d6 (mus musculus) (aka cd320 antigen)
E: mer6 (homo sapiens) (aka cd47 mol... | [H; H] |
<Instruct>: Given the context 'The 8D6 Ag is a novel protein of 282 amino acids that is expressed abundantly on FDCs.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: 8d6a (homo sapiens) (aka cd320 molecule)
B: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
C: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
D: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acet... | [A] |
<Instruct>: Given the context 'Monolayers of COS cells transiently transfected with the 8D6 Ag cDNA stimulate B cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
B: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
C: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
D: 8d6a (homo sapiens) (aka cd320 molecule)
E: lypd6 (homo sapiens) (aka l... | [D] |
<Instruct>: Given the context 'The mAb 8D6 blocks the costimulatory function completely.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6]
<Options>: A: defa6 (homo sapiens) (aka defensin alpha 6)
B: 8d6 (mus musculus) (aka cd320 antigen)
C: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
D: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
E: 8d6 (homo sapiens) (aka cd320 molecule)
F: Non... | [E] |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [8d6; cd40]
<Options>: A: cd40 (homo sapiens) (aka cd40 molecule)
B: cd40 molecule (oryctolagus cuniculus) (aka cd40 molecule)
C: dermatitis, atopic, 6 (homo sapiens) (aka dermatitis, atopic, 6)
D: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
E: 8d6 (homo sapiens) (aka cd320 mol... | [E; A] |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [8d6; cd40]
<Options>: A: dermatitis, atopic, 6 (homo sapiens) (aka dermatitis, atopic, 6)
B: tnfrsf4 (homo sapiens) (aka tnf receptor superfamily member 4)
C: cd40 molecule (oryctolagus cuniculus) (aka cd40 molecule)
D: cd40 molecule (bos taurus) (aka cd40 molecule)
E: d6 (homo sapiens) (aka atypical chemo... | [H; J] |
<Instruct>: Given the context 'In addition, the mAb 8D6 inhibits the growth of a lymphoma of GC origin, L3055, which depends on FDCs or HK cells for its growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [8d6]
<Options>: A: 8d6a (homo sapiens) (aka cd320 molecule)
B: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
C: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
D: defa6 (homo sapiens) (aka defensin alpha 6)
E: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial ... | [A] |
<Instruct>: Given the context 'An FDC signal molecule, 8D6 Ag, may be an important molecule to mediate this function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
B: 8d6 (mus musculus) (aka cd320 antigen)
C: 8d6 (homo sapiens) (aka cd320 molecule)
D: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
E: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
F: None of the above. | [C] |
<Instruct>: Given the context 'An FDC signal molecule, 8D6 Ag, may be an important molecule to mediate this function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
B: lypd6 (homo sapiens) (aka ly6/plaur domain containing 6)
C: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
D: 8d6 (mus musculus) (aka cd320 antigen)
E: None of the above. | [E] |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [leukosialin; cd43]
<Options>: A: gp3a (homo sapiens) (aka integrin subunit beta 3)
B: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
C: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
D: leukosialin-like (rattus norvegicus) (aka leukosialin-like)
E: sialin (homo sapiens) (aka solute carrier... | [I; I] |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [leukosialin; cd43]
<Options>: A: cd46 (homo sapiens) (aka cd46 molecule)
B: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
C: integrin binding sialoprotein (homo sapiens) (aka integrin binding sialoprotein)
D: spn (homo sapiens) (sialophorin (homo sapiens)) (aka sialophorin)
E: granulysin (homo sap... | [D; D] |
<Instruct>: Given the context 'This study analyzed the behavior of an antiadhesive membrane molecule, CD43, in neutrophil polarization and locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd43]
<Options>: A: cd43 (xenopus tropicalis) (aka sialophorin)
B: cd46 (homo sapiens) (aka cd46 molecule)
C: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
D: gp3a (homo sapiens) (aka integrin subunit beta 3)
E: cd43 (homo sapiens) (aka sialophorin)
F: None of the above. | [E] |
<Instruct>: Given the context 'CD43 cross-linking by antibodies induced neutrophil locomotion, with CD43 molecules clustered at the uropod of polarized neutrophils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [cd43]
<Options>: A: cd49c (homo sapiens) (aka integrin subunit alpha 3)
B: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
C: cd46 molecule (homo sapiens) (aka cd46 molecule)
D: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
E: cd43 (homo sapiens) (aka sialophorin)
F: None of the above. | [E] |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd11b; cd18]
<Options>: A: cd15 (homo sapiens) (aka fucosyltransferase 4)
B: cd11a (homo sapiens) (aka integrin subunit alpha l)
C: leukocyte receptor cluster member 8 (homo sapiens) (aka leukocyte receptor cluster member 8)
D: cd18 (homo sapiens) (aka integrin subunit beta 2)
E: cd1c molecule (homo sapien... | [G; D] |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd11b; cd18]
<Options>: A: cd128 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
B: cd48 (homo sapiens) (aka cd48 molecule)
C: cd11b (rattus norvegicus) (aka integrin subunit alpha m)
D: mac1a (homo sapiens) (aka integrin subunit alpha m)
E: itgax (mus musculus) (aka integrin alpha x)
F: slamf8 (homo... | [D; G] |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd11b; cd18]
<Options>: A: cd11b (rattus norvegicus) (aka integrin subunit alpha m)
B: cd118 (homo sapiens) (aka lif receptor subunit alpha)
C: cd11b (bos taurus) (aka integrin subunit alpha m)
D: cd11b (gallus gallus) (aka integrin, alpha d)
E: cd48 (homo sapiens) (aka cd48 molecule)
F: slamf8 (homo sapie... | [G; J] |
<Instruct>: Given the context 'Stimulation of suspended or adherent neutrophils with chemotactic peptide results in cell polarization and locomotion and a concomitant redistribution of CD43 to the uropod.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [cd43]
<Options>: A: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
B: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
C: cd49c (homo sapiens) (aka integrin subunit alpha 3)
D: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
E: cd43 (homo sapiens) (aka sialophorin)
F: None of th... | [E] |
<Instruct>: Given the context 'The study also investigated which actin-binding protein could be involved in CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd43]
<Options>: A: cd43 (xenopus tropicalis) (aka sialophorin)
B: cd46 (homo sapiens) (aka cd46 molecule)
C: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
D: cd43 (homo sapiens) (aka sialophorin)
E: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
F: None of the above. | [D] |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha-actinin; moesin]
<Options>: A: moesin pseudogene 1 (homo sapiens) (aka moesin pseudogene 1)
B: alpha-actinin, sarcomeric (caenorhabditis elegans) (aka alpha-actinin, sarcomeric)
C: actinin (xenopus laevis) (actinin alpha 1 l homeolog (xenopus laevis)) (aka actinin alpha 1 l homeolog)
D: moesin l home... | [H; I] |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha-actinin; moesin]
<Options>: A: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
B: moesin s homeolog (xenopus laevis) (aka moesin s homeolog)
C: moesin (homo sapiens) (aka moesin)
D: actn1 (homo sapiens) (aka actinin alpha 1)
E: actinin-4 (homo sapiens) (aka actinin alpha 4)
F: moesin (mus muscul... | [D; C] |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [moesin; cd43]
<Options>: A: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
B: moesin (homo sapiens) (aka moesin)
C: moesin (bos taurus) (aka moesin)
D: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
E: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
F: cd43 (homo sapiens) (aka si... | [B; F] |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [moesin; cd43]
<Options>: A: moesin l homeolog (xenopus laevis) (aka moesin l homeolog)
B: moesin (homo sapiens) (aka moesin)
C: moesin (mus musculus) (aka moesin)
D: erm (drosophila melanogaster) (moesin (drosophila melanogaster)) (aka moesin)
E: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
F: cd... | [B; F] |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [moesin; cd43]
<Options>: A: erm (drosophila melanogaster) (moesin (drosophila melanogaster)) (aka moesin)
B: cd43 (homo sapiens) (aka sialophorin)
C: gp3a (homo sapiens) (aka integrin subunit beta 3)
D: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
E: cd13 (homo sapiens) (aka alanyl aminopeptidase... | [J; B] |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha-actinin; cd43]
<Options>: A: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
B: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
C: actinin (xenopus laevis) (actinin alpha 1 s homeolog (xenopus laevis)) (aka actinin alpha 1 s homeolog)
D: cd46 molecule (homo sapiens) (aka cd46 molecule)... | [I; E] |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha-actinin; cd43]
<Options>: A: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
B: actn1 (homo sapiens) (aka actinin alpha 1)
C: actinin (xenopus laevis) (actinin alpha 1 l homeolog (xenopus laevis)) (aka actinin alpha 1 l homeolog)
D: cd46 molecule (homo sapiens) (aka cd46 molecule)
E: gp3b (hom... | [B; F] |
<Instruct>: Given the context 'These results shed new light on the role of CD43 membrane redistribution, which appears to be directly related to neutrophil polarity and locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [cd43]
<Options>: A: cd49c (homo sapiens) (aka integrin subunit alpha 3)
B: cd43 (homo sapiens) (aka sialophorin)
C: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
D: cd43 (xenopus tropicalis) (aka sialophorin)
E: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
F: None of the above. | [B] |
<Instruct>: Given the context 'Here, we show that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [kiaa0001]
<Options>: A: eg:eg0003.1 (drosophila melanogaster) (aka uncharacterized protein)
B: cg6001 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: eg:eg0002.1 (drosophila melanogaster) (aka yin)
D: heat repeat-containing protein 1 homolog (c... | [F] |
<Instruct>: Given the context 'Abnormal CAG repeat expansion in the alpha1A voltage-dependent calcium channel gene is associated with spinocerebellar ataxia type 6, an autosomal dominant cerebellar ataxia with a predominant loss of the Purkinje cell.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [alpha1a voltage-dependent calcium channel]
<Options>: A: cms1a (homo sapiens) (cholinergic receptor nicotinic alpha 1 subunit (homo sapiens)) (aka cholinergic receptor nicotinic alpha 1 subunit)
B: cacna1c (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 c)
C: cacna1a (homo sapiens) (aka ca... | [C] |
<Instruct>: Given the context 'A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).', select the correct biomedical concept for each mention using ... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
B: a1a (homo sapiens) (aka serpin family a member 1)
C: tubulin alpha 1a (homo sapiens) (aka tubulin alpha 1a)
D: integrin subunit alpha 1 (homo sapiens) (aka integrin s... | [E] |
<Instruct>: Given the context 'Human alpha1A channels carrying various polyglutamine length with or without NP were expressed in HEK293 cells, and channel properties were compared using a whole-cell voltage clamp technique.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [alpha1a]
<Options>: A: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
B: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: a1a (homo sapiens) (aka serpin family a member 1)
D: integrin subunit alpha 1 (homo sapiens) (aka integrin sub... | [B] |
<Instruct>: Given the context 'alpha1A(-NP), corresponding to P-type channel, with 24 and 28 polyglutamines found in patients showed the voltage dependence of inactivation shifting negatively by 6 and 11 mV, respectively, from the 13 polyglutamine control.', select the correct biomedical concept for each mention using ... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
C: tubulin alpha 1a (homo sapiens) (aka tubulin alpha 1a)
D: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
... | [A] |
<Instruct>: Given the context 'alpha1A(-NP), corresponding to P-type channel, with 24 and 28 polyglutamines found in patients showed the voltage dependence of inactivation shifting negatively by 6 and 11 mV, respectively, from the 13 polyglutamine control.', select the correct biomedical concept for each mention using ... | <Mentions>: [alpha1a]
<Options>: A: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
B: tubulin alpha 1a (homo sapiens) (aka tubulin alpha 1a)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
E: None of the above. | [E] |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alp... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
D: a1a (homo sapiens) (aka serpin family a member 1)
E: calc... | [E] |
<Instruct>: Given the context 'On the other hand, other types of neurons, expressing both alpha1A(-NP) and alpha1A(+NP), may survive because the positive shift of voltage-dependent inactivation of alpha1A(+NP) compensates Ca(2+) influx.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
B: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: integrin subunit alpha 1 (homo sapiens) (aka int... | [B] |
<Instruct>: Given the context 'Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [six2]
<Options>: A: six5 (homo sapiens) (aka six homeobox 5)
B: six4 (homo sapiens) (aka six homeobox 4)
C: six2 (xenopus tropicalis) (aka six homeobox 2)
D: six3 (homo sapiens) (aka six homeobox 3)
E: six homeobox 2 (homo sapiens) (aka six homeobox 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [sine oculis; so]
<Options>: A: sov (drosophila melanogaster) (aka small ovary)
B: arctus oculus (drosophila melanogaster) (aka arctus oculus)
C: sotos (homo sapiens) (aka nuclear receptor binding set domain protein 1)
D: soo (mus musculus) (aka sooty foot)
E: otx (drosophila melanogaster) (aka ocelliless)
... | [I; I] |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [sine oculis; so]
<Options>: A: oculess (drosophila melanogaster) (aka oculess)
B: oss (drosophila melanogaster) (suppressor of hairless (drosophila melanogaster)) (aka suppressor of hairless)
C: dood (homo sapiens) (aka atpase h+ transporting v1 subunit b2)
D: soho (danio rerio) (aka h6 family homeobox 4)
... | [F; F] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six3 (homo sapiens) (aka six homeobox 3)
B: six3 (gallus gallus) (aka six homeobox 3)
C: six3 (drosophila melanogaster) (aka optix)
D: six4/5 (drosophila melanogaster) (aka six4)
E: six6.1 (xenopus tropicalis) (aka six homeobox 6)
F: hoxa6 (homo sapiens) (aka homeobox a6)
G:... | [K; N; A] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six4/5 (drosophila melanogaster) (aka six4)
B: hairy and enhancer of split 3 (xenopus tropicalis) (aka hairy and enhancer of split 3)
C: six6.1 (xenopus tropicalis) (aka six homeobox 6)
D: six5 (homo sapiens) (aka six homeobox 5)
E: six3 (drosophila melanogaster) (aka optix)... | [D; G; N] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six homeobox 5 (homo sapiens) (aka six homeobox 5)
B: paired box protein 6 homolog (caenorhabditis elegans) (aka paired box protein 6 homolog)
C: d-six3 (drosophila melanogaster) (aka optix)
D: six3 (homo sapiens) (aka six homeobox 3)
E: six6 (xenopus laevis) (aka six homeob... | [A; F; D] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six6 (homo sapiens) (aka six homeobox 6)
B: hairy and enhancer of split 3 (xenopus tropicalis) (aka hairy and enhancer of split 3)
C: six5 (mus musculus) (aka sine oculis-related homeobox 5)
D: six3 (gallus gallus) (aka six homeobox 3)
E: six homeobox 5 (homo sapiens) (aka s... | [E; A; G] |
<Instruct>: Given the context 'We have cloned and characterised the gene that encodes human SIX2, elucidated its gene structure and conducted expression studies in a range of tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [six2]
<Options>: A: six2 (mus musculus) (aka sine oculis-related homeobox 2)
B: six6 (homo sapiens) (aka six homeobox 6)
C: six homeobox 2 (homo sapiens) (aka six homeobox 2)
D: six5 (homo sapiens) (aka six homeobox 5)
E: six4 (homo sapiens) (aka six homeobox 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'SIX2 is widely expressed in the late first-trimester fetus, but has a limited range of expression sites in the adult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [six2]
<Options>: A: six homeobox 2 (homo sapiens) (aka six homeobox 2)
B: six2 (mus musculus) (aka sine oculis-related homeobox 2)
C: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
D: six6 (homo sapiens) (aka six homeobox 6)
E: six4 (homo sapiens) (ak... | [A] |
<Instruct>: Given the context 'The expression pattern of SIX2 and its localisation to chromosome 2p15-p16 will be of use in assessing its candidacy in human developmental disorders.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [six2]
<Options>: A: six homeobox 2 (homo sapiens) (aka six homeobox 2)
B: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
C: six2 (xenopus tropicalis) (aka six homeobox 2)
D: six6 (homo sapiens) (aka six homeobox 6)
E: six5 (homo sapiens) (aka six home... | [A] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: parathyroid hormone-like hormone (rattus norvegicus) (aka parathyroid hormone-like hormone)
C: parathyroid hormone-related protein-like (xenopus laevis) (aka parath... | [G; G; G] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: parathyroid hormone-like hormone (rattus norvegicus) (aka parathyroid hormone-like hormone)
B: pro-trh (homo sapiens) (aka thyrotropin releasing hormone)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pthrp (... | [J; J; J] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
C: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid horm... | [C; C; C] |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pth; pth/pthrp receptor]
<Options>: A: pth (homo sapiens) (parathyroid hormone (homo sapiens)) (aka parathyroid hormone)
B: parathyroid hormone 2 receptor (homo sapiens) (aka parathyroid hormone 2 receptor)
C: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor... | [A; I] |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pth; pth/pthrp receptor]
<Options>: A: hpt (homo sapiens) (aka hypoparathyroidism)
B: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
C: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
D: parathyroid hormone 1 receptor (bos tau... | [I; C] |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pth; pth/pthrp receptor]
<Options>: A: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pthr1 (homo sapiens) (aka parathyroid ... | [B; D] |
<Instruct>: Given the context 'When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pthrp]
<Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone... | [C] |
<Instruct>: Given the context 'Although initially discovered in malignancies, PTHrP is now known to be produced by most cells and tissues in the body.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [pthrp]
<Options>: A: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
B: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
C: pthrp (bos taurus) (aka parathyroid hormone like hormone)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthrp (xenopus laevis) (aka parathyro... | [B] |
<Instruct>: Given the context 'It acts as an autocrine and paracrine mediator of cell proliferation and differentiation, effects which are mediated via the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [pth/pthrp receptor]
<Options>: A: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
B: pthr2 (homo sapiens) (aka parathyroid hormone 2 receptor)
C: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
D: pa... | [C] |
<Instruct>: Given the context 'Recent evidence also has shown that, directly after translation, PTHrP is able to enter the nucleus and/or nucleolus and influence cell cycle progression and apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [pthrp]
<Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase ... | [C] |
<Instruct>: Given the context 'In this study, we have either overproduced PTHrP or inhibited endogenous PTHrP production in the breast cancer cell line, MCF-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [pthrp]
<Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like horm... | [D] |
<Instruct>: Given the context 'Overexpression of PTHrP was associated with an increase in mitogenesis, whereas inhibiting endogenous PTHrP production resulted in decreased cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [pthrp]
<Options>: A: pthrp (bos taurus) (aka parathyroid hormone like hormone)
B: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
C: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
D: parathyroid hormone (homo sapiens) (aka parathyroid ho... | [E] |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [pthrp; pth/pthrp receptor]
<Options>: A: pthr2 (homo sapiens) (aka parathyroid hormone 2 receptor)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
D: pth promoter region (homo sapiens) (aka pth promoter regi... | [F; E] |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [pthrp; pth/pthrp receptor]
<Options>: A: pthrp (bos taurus) (aka parathyroid hormone like hormone)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
D: parathyroid hormone (homo sapiens... | [H; C] |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [pthrp; pth/pthrp receptor]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
C: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
D: pth1r (homo sapiens) (aka parathyroid hormone 1 receptor... | [C; D] |
<Instruct>: Given the context 'This latter effect is dependent on interaction with the receptor, in that exogenously added PTHrP moieties known not to interact with the receptor had no effect on cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [pthrp]
<Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: pthrp (bos taurus) (aka parathyroid hormone like hormone)
D: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 re... | [E] |
<Instruct>: Given the context 'Furthermore, neutralization of added peptide with an anti-PTHrP antiserum completely abolished the growth inhibitory effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [pthrp]
<Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
D: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
E: pth promoter region ... | [D] |
<Instruct>: Given the context 'In contrast, this antibody has no effect on the increased proliferation rate of the MCF-7 transfectants that overexpress PTHrP, compared with control cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
C: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
D: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
E: pthrp (bos taurus) (ak... | [B] |
<Instruct>: Given the context 'The net effect of autocrine/paracrine and intracrine effects of PTHrP in MCF-7 cells overproducing the peptide is accelerated cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [pthrp]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
E: pthrp (xenopus laevis) (aka parathy... | [B] |
<Instruct>: Given the context 'These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [pthrp]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
C: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone)
E: pthrp (homo sapiens) (aka... | [E] |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p-selectin ligand; psgl-1]
<Options>: A: cd62 (homo sapiens) (aka selectin p)
B: selectin e (homo sapiens) (aka selectin e)
C: psbg-1 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 1)
D: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
E: psg1 (homo sapiens) (pregnancy specifi... | [H; H] |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p-selectin ligand; psgl-1]
<Options>: A: selectin e (homo sapiens) (aka selectin e)
B: psbg-1 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 1)
C: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
D: selp (homo sapiens) ... | [G; G] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: selectin-e (homo sapiens) (aka selectin e)
B: psbg-1 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 1)
C: selectin p ligand (sus scrofa) (aka selectin p ligand)
D: selp (homo sapiens) (selectin p (homo sapiens)) (aka selectin p)
... | [F; L; L] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: selectin-e (homo sapiens) (aka selectin e)
B: psgb-5-1 (homo sapiens) (aka cytochrome b5 type a pseudogene 3)
C: selp (homo sapiens) (selectin p (homo sapiens)) (aka selectin p)
D: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein ... | [C; J; J] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: selectin-e (homo sapiens) (aka selectin e)
B: cd62p (homo sapiens) (aka selectin p)
C: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
D: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka p... | [J; F; F] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: cd62p (homo sapiens) (aka selectin p)
B: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
C: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
D: selectin p (sus scrofa) (aka selectin p)
E: selectin-e (hom... | [G; K; K] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
B: fuct-vii (xenopus tropicalis) (aka fucosyltransferase 7 (alpha (1,3) fucosyltransferase))
C: alpha1,3-fucosyltransferase a (drosophila melanogaster) (aka alpha1,3-fucosyltra... | [G; K; K] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: fucosyltransferase 7 (homo sapiens) (aka fucosyltransferase 7)
B: fuc-tvii (mus musculus) (aka fucosyltransferase 7)
C: psgl-1 (homo sapiens) (aka selectin p ligand)
D: fucosyltransferase 10 (alpha (1,3) fucosyltransferase) (xenopus tropicalis... | [C; A; A] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
B: fuct-vii (bos taurus) (aka fucosyltransferase 7)
C: alpha-(1,3)-fucosyltransferase fut-1 (caenorhabditis elegans) (aka alpha-(1,3)-fucosyltransferase fut-1)
D: psg1 (homo sa... | [L; F; F] |
<Instruct>: Given the context 'Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [psgl-1]
<Options>: A: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
B: psgl1 (homo sapiens) (aka selectin p ligand)
C: psg5 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 5)
D: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 1 (homo sapiens)) (aka pregnancy spec... | [B] |
<Instruct>: Given the context 'Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [psgl-1]
<Options>: A: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
B: psg5 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 5)
C: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 1 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 1)
D: psggb (homo sapie... | [E] |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
B: mp (mus musculus) (aka micropinna microphthalmia)
C: thymine dna glycosylase (mus musculus) (aka thymine dna glycosylase)
D: n-methylpurine dna glycosylase (homo sapiens) (aka n-methylpurine dna g... | [D; D] |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: n-methylpurine dna glycosylase (homo sapiens) (aka n-methylpurine dna glycosylase)
B: n-methylpurine-dna glycosylase (mus musculus) (aka n-methylpurine-dna glycosylase)
C: 8-oxoguanine dna-glycosylase 1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
... | [A; A] |
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