instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: ppg (mus musculus) (aka glucagon)
B: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
C: thymine dna glycosylase (mus musculus) (aka thymine dna glycosylase)
D: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
E: mpg1 (... | [G; G] |
<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: mgp (homo sapiens) (aka matrix gla protein)
B: dna-3-methyladenine glycosylase 1-like (glycine max) (aka dna-3-methyladenine glycosylase 1-like)
C: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: n-methylpurine dna glycos... | [D; D] |
<Instruct>: Given the context 'In comparison, homologues of the Rad23 proteins (hHR23) and the hXPC protein are involved in the recognition of damaged bases in global genome repair, a subset of nucleotide excision repair.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [hxpc]
<Options>: A: hppc (homo sapiens) (aka alkaline phosphatase, biomineralization associated)
B: hpcx (homo sapiens) (aka hereditary prostate cancer, x-linked)
C: cphx (homo sapiens) (aka tmem254 antisense rna 1)
D: hcypx (homo sapiens) (aka peptidylprolyl isomerase like 1)
E: hypc (xenopus tropicalis) ... | [F] |
<Instruct>: Given the context 'In this report, we show that the hHR23A and -B also interact with the MPG protein and can serve as accessory proteins for DNA damage recognition in base excision repair.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [mpg]
<Options>: A: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
B: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
C: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
D: mpg-1 (homo sapiens) (aka macrophage expressed 1)
E: mgp (mus musculus) (aka matrix gla protein)
F: Non... | [C] |
<Instruct>: Given the context 'In this report, we show that the hHR23A and -B also interact with the MPG protein and can serve as accessory proteins for DNA damage recognition in base excision repair.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [mpg]
<Options>: A: mpg-1 (homo sapiens) (aka macrophage expressed 1)
B: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
C: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
D: mgp (mus musculus) (aka matrix gla protein)
E: None of the above. | [E] |
<Instruct>: Given the context 'Furthermore, the MPG.hHR23 protein complex elevates the rate of MPG protein-catalyzed excision from hypoxanthine-containing substrates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [mpg]
<Options>: A: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
B: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
C: ppg (mus musculus) (aka glucagon)
D: mp (mus musculus) (aka micropinna microphthalmia)
E: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
F: None of the a... | [A] |
<Instruct>: Given the context 'This increased excision rate is correlated with a greater binding affinity of the MPG protein-hHR23 protein complex for damaged DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mpg]
<Options>: A: mpg1 (homo sapiens) (aka macrophage expressed 1)
B: mgp (homo sapiens) (aka matrix gla protein)
C: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
D: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
E: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
F: None of the a... | [E] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
B: htra serine peptidase 1 (homo sapiens) (aka htra serine peptidase 1)
C: antxr2 (homo sapiens) (aka antxr cell adhesion molecule 2)
D: htr2a (homo sapiens) (aka 5-hydroxytryptamine receptor 2a)
E: htra serine pepti... | [E; E; E] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: om (drosophila melanogaster) (aka ommatidia)
B: htra serine peptidase 2 (sus scrofa) (aka htra serine peptidase 2)
C: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
D: hthtr2 (homo sapiens) (aka solute carrier family 19 member 3)
E: mxra2 (homo sapiens) (aka parv... | [N; N; N] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: omm (drosophila melanogaster) (aka ommatoreductum)
B: htra2 (homo sapiens) (aka htra serine peptidase 2)
C: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
D: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
E: om (drosophila melanogaster) (aka ommati... | [B; B; B] |
<Instruct>: Given the context 'In this report we describe the overexpression of humHtrA2 in two heterologous systems comparing the merits of each.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humhtra2]
<Options>: A: atoh2 (homo sapiens) (aka neuronal differentiation 6)
B: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
C: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
D: antxr2 (homo sapiens) (aka antxr cell adhesion molecule 2)
E: htpcr2 (homo sapiens) (aka olfactory re... | [F] |
<Instruct>: Given the context 'By means of fluorescently labeled substrates alpha- and beta-casein and zymography, the proteolytic activity of recombinant HumHtrA2 was also demonstrated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [humhtra2]
<Options>: A: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
B: htpcr2 (homo sapiens) (aka olfactory receptor family 7 subfamily a member 5)
C: ear2 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 6)
D: antxr2 (homo sapiens) (aka antxr cell adhesion molecule 2)
E: atoh2 ... | [F] |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [il-2; p21snft]
<Options>: A: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
B: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
C: il22 (homo sapiens) (aka interleukin 22)
D: csf2 (homo sapiens) (aka colony stimulating factor 2)
E: nft1 (saccharomyces cerevisiae s288c) (u... | [I; B] |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [il-2; p21snft]
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: nft1 (saccharomyces cerevisiae s288c) (putative multidrug transporter nft1 (saccharomyces cerevisiae s288c)) (aka putative multidrug transporter nft1)
C: il-2 (homo sapiens) (aka interleukin 2)
D: ilf2 (homo sapiens) (aka... | [C; F] |
<Instruct>: Given the context 'The inducible expression of IL-2 is highly regulated by multiple transcription factors, particularly AP-1, which coordinately activate the promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [il-2]
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: il22 (homo sapiens) (aka interleukin 22)
C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
D: il2 (homo sapiens) (aka interleukin 2)
E: interleukin enhancer binding factor 2 (homo sapiens) (aka interl... | [D] |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [p21snft; il-2]
<Options>: A: csf2 (homo sapiens) (aka colony stimulating factor 2)
B: nft1 (saccharomyces cerevisiae s288c) (putative multidrug transporter nft1 (saccharomyces cerevisiae s288c)) (aka putative multidrug transporter nft1)
C: snft (homo sapiens) (aka basic leucine zipper atf-like transcriptio... | [C; J] |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [p21snft; il-2]
<Options>: A: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
B: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
C: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
D: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
E: ... | [J; E] |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [p21snft; il-2]
<Options>: A: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
B: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
C: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized pro... | [F; H] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3)
B: juno (homo sapiens) (aka izumo1 receptor, juno)
C: c-jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
D: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb p... | [S; E; C; M] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
B: interleukin 3 (homo sapiens) (aka interleukin 3)
C: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
D: il2 (homo sapiens) (aka interleukin 2)
E: ntf2 (... | [L; D; T; H] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)) (aka jun proto-oncogene, ap-1 transcription factor subunit)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: colony stimulating factor 2 (homo sapiens) (aka colony st... | [T; P; A; K] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
B: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
C: rft1 homolog (rattu... | [O; G; A; Q] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
B: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
C: il22 (homo sapiens) (aka interleukin 22)
D: ... | [O; H; I; L] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [jun]
<Options>: A: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
B: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
C: c-jun (homo sapiens)... | [C] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biom... | <Mentions>: [p21snft; jun; il-2]
<Options>: A: nst1 (saccharomyces cerevisiae s288c) (aka nst1p)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: juno (homo sapiens) (aka izumo1 receptor, juno)
D: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
E: junb proto-oncogene, ap-1 tran... | [D; G; I] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biom... | <Mentions>: [p21snft; jun; il-2]
<Options>: A: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
B: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
C: juno (homo sapiens) (aka izumo1 receptor, juno)
D: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jun... | [A; M; G] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biom... | <Mentions>: [p21snft; jun; il-2]
<Options>: A: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: jund proto-oncogene, ap-1 transcription factor subunit (h... | [A; O; L] |
<Instruct>: Given the context 'Identification of distinct surface-expressed and intracellular CXC-chemokine receptor 2 glycoforms in neutrophils: N-glycosylation is essential for maintenance of receptor surface expression.
', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [cxc-chemokine receptor 2]
<Options>: A: chemokine (c-c motif) receptor 2 (xenopus tropicalis) (aka chemokine (c-c motif) receptor 2)
B: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: atypical chemokine receptor 2 (homo sapiens) (... | [C] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: il18 (homo sapiens) (aka interleukin 18)
B: x-c motif chemokine ligand 2 (homo sapiens) (aka x-c motif chemokine ligand 2)
C: ck-8 (homo sapiens) (aka keratin 8)
D: nac-2 (homo sapiens) (aka nacc family member 2)
E: mip-2b (homo sapiens) (... | [Q; P; O; O] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
B: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: x-c motif chemokine l... | [B; I; Q; Q] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: nac-2 (homo sapiens) (aka nacc family member 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: il8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
D: ckr2 (homo sapiens) (aka c-c moti... | [K; C; O; O] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
B: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: c-x-c motif chemokine ligand 2 (homo sapiens) (aka c-x-c motif chemokin... | [I; A; M; M] |
<Instruct>: Given the context 'Although CXCR-2 has been successfully cloned and expressed in several cell lines, the molecular properties of the native neutrophil-expressed receptor have remained largely undefined.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [cxcr-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | [C] |
<Instruct>: Given the context 'Here we report on the identification and characterization of distinct CXCR-2 glycoforms and their subcellular distribution in neutrophils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [cxcr-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention u... | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
B: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
C: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: nap-2 (homo sapiens) (aka pro-platelet bas... | [F; D; C] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention u... | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: ck-8 (homo sapiens) (aka keratin 8)
D: nap-2 (homo sapiens) (aka pro-platelet basic protein)
E: il18 (... | [M; D; F] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention u... | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
B: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
C: nap-2 (homo sapiens) (aka pro-platelet basic protein)
D: c-c motif chemokine rece... | [E; C; K] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention u... | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
B: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
D: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like... | [I; E; B] |
<Instruct>: Given the context 'According to deglycosylation experiments surface-expressed CXCR-2 carries two N-linked 9-kDa carbohydrate moieties that are both of complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [cxcr-2]
<Options>: A: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | [C] |
<Instruct>: Given the context 'In addition, two other CXCR-2 variants of 38 and 40 kDa were found to occur exclusively intracellular and to carry N-glycosylations of high mannose or hybrid type.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [cxcr-2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | [C] |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: nap-2 (homo sapiens) (aka pro-platelet basic protein)
B: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
E: nipsnap homolog 2 (xenopus tropi... | [H; A] |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
B: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
C: nucleic acid binding protein 2 (homo sapiens) (aka nucleic acid binding protein 2)
D: nap-2 (homo sapiens) (aka pro-platelet basic protein)
E: nap2l (ho... | [H; D] |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: nap-2 (homo sapiens) (aka pro-platelet basic protein)
B: nac-2 (homo sapiens) (aka nacc family member 2)
C: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
D: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptid... | [E; A] |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
B: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
C: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: nabp2 (homo sapiens) (aka nucleic acid binding protein 2)
E: nap-2 (homo sapiens) ... | [C; E] |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
D: nap2 (homo sapiens) (napsin b aspartic peptidase (pse... | [A; F] |
<Instruct>: Given the context 'Instead, glycosylation was found to protect CXCR-2 from proteolytic attack, as even partial deglycosylation is associated with serine protease-mediated disappearance of the receptor from the neutrophil surface.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [cxcr-2]
<Options>: A: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | [A] |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [trek2; 2p domain mechano-sensitive k+ channel]
<Options>: A: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: katp-2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 6)
C: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily ... | [C; C] |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [trek2; 2p domain mechano-sensitive k+ channel]
<Options>: A: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k ... | [A; A] |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; trek1]
<Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
C: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek-1 (xenopus tropicalis)... | [H; C] |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; trek1]
<Options>: A: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: trek-1 (homo sapiens) (aka potassi... | [B; D] |
<Instruct>: Given the context 'TREK2 is abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [trek2]
<Options>: A: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: tresk2 (homo sapie... | [C] |
<Instruct>: Given the context 'In the central nervous system, TREK2 has a widespread distribution with the highest levels of expression in cerebellum, occipital lobe, putamen, and thalamus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [trek2]
<Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
D: trek (homo sapiens)... | [B] |
<Instruct>: Given the context 'In transfected cells, TREK2 produces rapidly activating and non-inactivating outward rectifier K(+) currents.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: task-2 (homo sapi... | [B] |
<Instruct>: Given the context 'TREK2 is blocked by application of intracellular cAMP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek-1 (homo sapi... | [C] |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [trek1; trek2]
<Options>: A: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
B: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek-2 (xenopus trop... | [C; G] |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [trek1; trek2]
<Options>: A: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: trek-1 (mus musculus... | [J; A] |
<Instruct>: Given the context 'TREK2 can be positively or negatively regulated by a variety of neurotransmitter receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: task-2 (homo sapiens) (aka p... | [A] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: htr4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
C: gpr2 (homo sapiens) (aka c-c motif chemokine receptor 10)
D: 5-ht4r (homo sapiens) (aka 5-hydroxytryptamine re... | [D; Q; I; A] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: mglur2 (homo sapiens) (aka glutamate metabotropic receptor 2)
B: mglur2 (mus musculus) (aka glutamate receptor, metabotropic 2)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: gpr2 (homo sapiens) (aka c-c motif chemokine... | [T; L; A; I] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: glutamate receptor, metabotropic 1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k memb... | [R; L; E; J] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: corticotropin releasing hormone receptor 2 (mus musculus) (aka corticotropin releasing hormone receptor 2)
B: 5-hydroxytryptamine receptor 4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
C: mglur5 (homo sapiens) (aka glutamate metabotropic receptor 5)... | [N; O; L; F] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: metabotropic glutamate receptor 1 (xenopus tropicalis) (aka metabotropic glutamate receptor 1)
B: corticotropin releasing hormone receptor 2 (mus musculus) (aka corticotropin releasing hormone receptor 2)
C: mglur2 (homo sapiens) (aka glutamate metabotropic rece... | [N; T; C; I] |
<Instruct>: Given the context 'These multiple types of regulations suggest that TREK2 plays an important role as a target of neurotransmitter action.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek2 (homo sapie... | [D] |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [shp2; interleukin-6]
<Options>: A: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: cdf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: hbgf-6 (homo sapiens) (aka fibroblast gr... | [A; B] |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [shp2; interleukin-6]
<Options>: A: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
D: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogen... | [F; G] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: interleukin 6 (homo sapiens) (aka interleukin 6)
C: pyk2 (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
D: frk (xenopus tropicalis) (aka fyn relate... | [G; G; G; B] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: pyk2 (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
C: raftk (xenopus laevis) (protein tyrosine kinas... | [N; N; N; L] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
B: focal adhesion kinase (drosophila melanogaster) (aka focal adhesion kinase)
C: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
D: interl... | [J; J; J; D] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
B: pdpk2 (homo sapiens) (aka 3-phosphoinositide dependent protein kinase 1)
C: frnk (homo sapiens) (aka protein tyrosine kinase 2)
D: raftk (xenopus tropicalis)... | [M; M; M; H] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [il-6; raftk]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: interleukin 6 (homo sapiens) (aka interleukin 6)
C: frnk (homo sapiens) (aka protein tyrosine kinase 2)
D: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
E: fibroblast growth factor 6 (homo sapiens) (aka fibrob... | [B; F] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [il-6; raftk]
<Options>: A: cdf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
C: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
D: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: cdf (ho... | [A; D] |
<Instruct>: Given the context 'However, the mechanism whereby IL-6 inhibits Dex-induced apoptosis is undefined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6]
<Options>: A: interleukin 6 (homo sapiens) (aka interleukin 6)
B: interleukin 7 (homo sapiens) (aka interleukin 7)
C: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
D: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
E: None of the above. | [A] |
<Instruct>: Given the context 'In this study, we demonstrate that protein-tyrosine phosphatase SHP2 mediates this protective effect.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2]
<Options>: A: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
E: ptpn12 (homo sapiens) (ak... | [A] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: frnk (homo sapiens) (aka protein tyrosine kinase 2)
B: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
C: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
D: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka... | [B; G; H] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: protein tyrosine phosphatase non-receptor t... | [N; K; D] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: interleukin 6 (homo sapiens) (aka interleukin 6)
B: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: interleukin 7 (... | [A; D; C] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
C: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
D: hbgf-6 (homo sapiens... | [E; G; K] |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; raftk]
<Options>: A: frnk (homo sapiens) (aka protein tyrosine kinase 2)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: raftk (mus musculus) (a... | [C; F] |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; raftk]
<Options>: A: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: frk (drosophila melanogaster) (aka franklin)
D: frk (bos taurus) (aka fyn related src fami... | [I; J] |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; raftk]
<Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: frnk (homo sapiens) (aka protein tyrosine kinase 2)
C: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
D: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: ptpn2p2 (homo sap... | [J; D] |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [raftk; shp2]
<Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
D: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: sh-ptp2 (homo sa... | [D; E] |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [raftk; shp2]
<Options>: A: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
E: frnk (h... | [A; C] |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [shp2; il-6]
<Options>: A: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
B: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
C: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor ... | [H; F] |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [shp2; il-6]
<Options>: A: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: interleukin 7 (homo sapiens) (aka interleukin 7)
E: ptpn2... | [H; F] |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [shp2; il-6]
<Options>: A: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: shp2 (homo sapiens) (aka protein tyrosine phosph... | [D; A] |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [shp2; il-6]
<Options>: A: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
B: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
C: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor ... | [I; H] |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [shp2; il-6]
<Options>: A: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
E: interleukin 7 (homo s... | [I; A] |
<Instruct>: Given the context 'Here, we examined the effect of alpha(2) agonists on a clone of Caco2 cells expressing the human alpha(2A) adrenoceptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha(2a) adrenoceptor]
<Options>: A: adrenoceptor alpha 1b (homo sapiens) (aka adrenoceptor alpha 1b)
B: adra2a (homo sapiens) (aka adrenoceptor alpha 2a)
C: alpha2car (homo sapiens) (aka adrenoceptor alpha 2c)
D: alpha2bar (homo sapiens) (aka adrenoceptor alpha 2b)
E: None of the above. | [B] |
<Instruct>: Given the context 'Cells were transfected with a bicistronic plasmid containing the alpha2C10 and neomycin phosphotransferase genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha2c10]
<Options>: A: protocadherin alpha 10 (homo sapiens) (aka protocadherin alpha 10)
B: alpha2aar (homo sapiens) (aka adrenoceptor alpha 2a)
C: cyclic nucleotide gated channel subunit alpha 2 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 2)
D: cholinergic receptor nicotinic alpha... | [B] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk-1 (homo sapiens) (aka mitogen-activated protein kinase 3)
B: mitogen-activated protein kinase kinase 2 (homo sapiens) (aka mitogen-activated protein kinase kinase 2)
C: mitogen-activated protein kinase 1 (homo sapiens) (aka mitogen-act... | [A; A; L] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk2 (mus musculus) (aka mitogen-activated protein kinase 1)
B: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
C: erk6 (homo sapiens) (aka mitogen-activated protein kinase 12)
D: mapkk2 (homo sapiens) (aka mitogen-activated p... | [J; J; F] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: mapkk2 (homo sapiens) (aka mitogen-activated protein kinase kinase 2)
B: mitogen-activated protein kinase 1 (homo sapiens) (aka mitogen-activated protein kinase 1)
C: erk2 (xenopus tropicalis) (aka mitogen-activated protein kinase 1)
D: er... | [J; J; D] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: mitogen-activated protein kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
B: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
C: erk-1 (homo sapiens) (aka mitogen-activated protein kinase 3)
D: er... | [C; C; M] |
<Instruct>: Given the context 'It was unaffected by protein kinase C downregulation but correlated with a transient increase in Shc tyrosine phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [shc]
<Options>: A: shc (homo sapiens) (aka shc adaptor protein 1)
B: shcc (homo sapiens) (aka shc adaptor protein 3)
C: shc2 (homo sapiens) (aka shc adaptor protein 2)
D: None of the above. | [A] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: interleukin 10 (homo sapiens) (aka interleukin 10)
B: il4 (bos taurus) (aka interleukin 4)
C: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
D: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
E: ifi11... | [G; I; L; L] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: interleukin 10 (homo sapiens) (aka interleukin 10)
D: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine r... | [I; H; J; J] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
D: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine recepto... | [R; D; H; H] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
B: il-10c (homo sapiens) (aka interleukin 19)
C: ifi11 (homo sapiens) (aka immunity related gtpase m)
D: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemo... | [J; K; H; H] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: ifitm10 (homo sapiens) (aka interferon induced transmembrane protein 10)
C: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
D: bolf1 (human... | [N; S; Q; Q] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
B: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
C: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
D: ifn-alphac (homo sa... | [E; E; C; C] |
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