instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: scya27 (homo sapiens) (aka c-c motif chemokine ligand 27)
B: ifi78 (homo sapiens) (aka mx dynamin like gtpase 1)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: i-tac (homo sapiens) (aka... | [J; J; D; D] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: mig9 (homo sapiens) (aka s100 calcium binding protein p)
B: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
C: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
D: ifn-alphac (homo sapi... | [E; E; G; G] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
B: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
C: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
D: midkine (homo ... | [J; J; B; B] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [cxcr3 receptor]
<Options>: A: cxcr3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
B: atypical chemokine receptor 3 (xenopus tropicalis) (aka atypical chemokine receptor 3)
C: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
D: cc-ckr-3 (homo sapiens) (aka... | [E] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: il-17 (bos taurus) (aka interleukin 17a)
B: il-4 (bos taurus) (aka interleukin 4)
C: il-17a (homo sapiens) (aka interleukin 17a)
D: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
F: il-17f (h... | [N; L; C; I] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: il10 (homo sapiens) (aka interleukin 10)
B: il-4 (bos taurus) (aka interleukin 4)
C: interleukin 4 (homo sapiens) (aka interleukin 4)
D: il-17f (homo sapiens) (aka interleukin 17f)
E: interleukin 10 (bos taurus) (aka interleukin 10)
F: interleukin 5 (homo sapiens) (... | [C; A; H; G] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
D: il-17 (bos taurus) (aka interleukin 17a)
E: interleukin-10 (human betaherpes... | [Q; F; K; B] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
C: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
D: il-17 (bos taurus) (aka interleukin 17a)
E: interleukin 1... | [R; K; Q; F] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
C: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: c-x-c moti... | [D; L; A] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
D: mig-6 (mus musculus) (aka erbb receptor feedback inh... | [I; C; G] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
B: ik cytokine (homo sapiens) (aka ik cytokine)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
D: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c... | [N; A; O] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interleukin 4 (bos taurus) (aka interleukin 4)
B: interferon gamma (xenopus tropicalis) (aka interferon gamma)
C: il-17 (bos taurus) (aka interleukin 17a)
D: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
E: interferon gamma (homo sapiens) (aka i... | [I; S; K; E] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interleukin 17c (homo sapiens) (aka interleukin 17c)
B: il-10c (homo sapiens) (aka interleukin 19)
C: interferon gamma (mus musculus) (aka interferon gamma)
D: il-17 (bos taurus) (aka interleukin 17a)
E: interferon gamma (homo sapiens) (aka interferon gamma)
F: ... | [I; S; N; E] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: interleukin 10 (bos taurus) (aka interleukin 10)
D: il-17f (homo sapiens) (aka interleukin 17f)
E: il-4 (homo sapiens) (aka interleukin 4)
F: interferon gamm... | [E; L; S; N] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interleukin 10 (oryctolagus cuniculus) (aka interleukin 10)
B: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
C: il-17c (homo sapiens) (aka interleukin 17c)
D: interleukin 17f (homo sapiens) (aka interleukin 17f)
E: interferon gamma (homo sapiens... | [R; G; J; E] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interleukin 10 (bos taurus) (aka interleukin 10)
B: il-17a (homo sapiens) (aka interleukin 17a)
C: il-10c (homo sapiens) (aka interleukin 19)
D: interleukin 17f (homo sapiens) (aka interleukin 17f)
E: interleukin 5 (homo sapiens) (aka interleukin 5)
F: il-10 (or... | [J; K; B; Q] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
B: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
D: mig-6 (homo sapiens) (aka erbb receptor feed... | [P; B; N; S] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
B: tnfa (homo sapiens) (aka tumor necrosis factor)
C: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
D: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
E: il-10c (homo sapiens) (aka interle... | [B; N; L; D] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
B: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
C: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
D: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
E: mig9 (hom... | [M; J; H; D] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
B: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
C: tac1 (homo sapiens) (aka tachykinin precursor 1)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: c-sis (... | [O; R; D; T] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
C: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
D: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
E: interferon alpha 10 (ho... | [D; G; I; R] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [ip-10; mig]
<Options>: A: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: mig1 (homo sapiens) (aka vacuolar protein s... | [G; D] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [ip-10; mig]
<Options>: A: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: il-10c (homo sapiens) (aka interleukin 19)
D: mig9 (homo sapiens) (aka s100 calcium binding protein p)
E: interleukin 1 family member 10 (homo sapiens) (aka interleu... | [G; J] |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [cxcr3]
<Options>: A: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
B: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
C: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif che... | [D] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: il4 (homo sapiens) (aka interleukin 4)
B: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
D: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
E: interfe... | [E; A; B] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: il4 (homo sapiens) (aka interleukin 4)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: interferon gamma (gallus gallus) (aka interferon gamma)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: c-x-c motif ... | [G; A; E] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor... | [D; L; C] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: interferon gamma (mus musculus) (aka interferon gamma)
D: il4 (homo sapiens) (aka interleukin 4)
E: c-c chemokine receptor type 3 (xenopus tropi... | [O; I; D] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: gmf-gamma (homo... | [D; N; F] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interferon gamma (gallus gallus) (aka interferon gamma)
B: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
C: interferon gamma (mus musculus) (aka interferon gamma)
D: ifn-gamma (gallus gallus) (aka interferon)
E: bllf1 (human gammaherpesvirus 4) (aka gly... | [K; G; M] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: ifn-alpha (homo sapiens) (aka interferon alpha 1)
B: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: interferon gamma (sus scrofa) (aka interferon gamma)
D: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
E: interleukin 10 (homo sa... | [K; M; P; B] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: interleukin 4 (homo sapiens) (aka interleukin 4)
B: il-10c (homo sapiens) (aka interleukin 19)
C: interferon gamma (sus scrofa) (aka interferon gamma)
D: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
E: scya10 (homo sapiens) (aka c-c motif chemokin... | [A; G; T; S] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: il-4 (homo sapiens) (aka interleukin 4)
D: il-4 (bos taurus) (aka interleukin 4)
E: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F... | [C; P; S; E] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: interleukin 4 (homo sapiens) (aka interleukin 4)
B: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
C: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
D: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
E: il4 (bos taurus) (aka i... | [A; O; J; Q] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
B: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
C: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
D: mig9 (homo sapiens) (aka s100 calcium binding protein p)
E: mi... | [E; F; M] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
B: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
D: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
E: ik cy... | [G; J; L] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor... | [F; O; M] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [graf; mll]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: mll (homo sapiens) (aka lysine methyltransferase 2a)
C: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to... | [E; B] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [graf; mll]
<Options>: A: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
B: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf (homo sapiens) (aka rho gtpase act... | [D; B] |
<Instruct>: Given the context 'We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf1 (homo sapiens) (aka rho gtpase activating protein... | [D] |
<Instruct>: Given the context 'This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [mll]
<Options>: A: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
C: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
D: myeloid/lymp... | [C] |
<Instruct>: Given the context 'GRAF encodes a member of the Rho family of the GTPase-activating protein (GAP) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
D: grf1 (homo sapiens) (aka ras protein specific guan... | [E] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [graf; rhoa]
<Options>: A: rhoa (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
B: rhoa-a (xenopus laevis) (ras homolog family member a s homeolog (xenopus laevis)) (aka ras homolog family member a s homeolog)
C: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
D: rho family... | [K; K] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [graf; rhoa]
<Options>: A: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
B: rhoa-a (xenopus laevis) (ras homolog family member a s homeolog (xenopus laevis)) (aka ras homolog family member a s homeolog)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
... | [K; K] |
<Instruct>: Given the context 'The particular position of the human GRAF gene at 5q31 and the proposed antiproliferative and tumor suppressor properties of its avian homologue suggest that it also might be pathogenetically relevant for hematologic malignancies with deletions of 5q.', select the correct biomedical conce... | <Mentions>: [graf]
<Options>: A: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
B: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
E: graf3 (h... | [D] |
<Instruct>: Given the context 'To investigate this possibility, we sequenced 4-5 individual cDNA clones from 13 cases in which one allele of GRAF was deleted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [graf]
<Options>: A: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide r... | [E] |
<Instruct>: Given the context 'We found point mutations within the GAP domain of the second GRAF allele in one patient.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: grap (homo sapiens) (aka grb2 related adaptor protein)
B: graf (homo sapiens) (aka rho gtpase activating protein 26)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing fa... | [B] |
<Instruct>: Given the context 'In two additional patients we found an insertion of 52 or 74 bp within the GRAF cDNA that generates a reading frame shift followed by a premature stop codon.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [graf]
<Options>: A: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
D: graf2 (homo sapiens) (aka rho gtpase activatin... | [B] |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf (homo sapiens) (aka rho gtpase activatin... | [D] |
<Instruct>: Given the context 'Nevertheless, inactivation of both alleles in at least some cases suggests that deletions and mutations of the GRAF gene may be instrumental in the development and progression of hematopoeitic disorders with a del(5q).', select the correct biomedical concept for each mention using the pro... | <Mentions>: [graf]
<Options>: A: graf (xenopus tropicalis) (aka rho gtpase activating protein 26)
B: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
E: graf-1ef (homo sapiens) (aka eukary... | [D] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
B: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
C: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
D: ckr1 (homo sapiens) (aka c-c motif... | [G; D; K; G] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
C: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
D: c-c motif chemokine ligand 26 (homo... | [J; M; E; J] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: ld78 (homo sapiens) (c-c motif chemokine ligand 3 (homo sapiens)) (aka c-c motif chemokine ligand 3)
B: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
C: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
D: cc-ckr-9 (homo sapi... | [S; K; J; S] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: c-c motif chemokine ligand 26 (homo sapiens) (aka c-c motif chemokine ligand 26)
B: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
C: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
D: lecd (homo sapiens)... | [N; C; P; N] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
C: lmnc (xenopus tropicalis) (aka lamin a/c)
D: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
E: c-c motif chemokine 4 ho... | [J; J; J; J] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
B: lmnc (xenopus tropicalis) (aka lamin a/c)
C: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif chemokine 4 homolog)
D: ncc-4 (mus musculus) (aka c-c motif chemokine lig... | [F; F; F; F] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
D: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
E: b3... | [A; A; A; A] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: hcc-4 (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
B: ncc-1 (homo sapiens) (aka c-c motif chemokine ligand 13)
C: lmc (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
D: ncc-4 (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene... | [J; J; J; J] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ccl16]
<Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
C: c-c motif chemokine ligand 16 (sus scrofa) (aka c-c motif chemokine ligand 16)
D: ccl26 (homo sapiens) (aka c-c motif chemokin... | [B] |
<Instruct>: Given the context 'Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [lec]
<Options>: A: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
B: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
E: lecd (homo sapiens) (aka muco... | [D] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: cmkbr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
D: lce (homo sapiens) (aka elovl fatty acid elongase 6)
E: cc-ckr-9 (homo sapiens) ... | [N; H; A] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
C: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
D: ccr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
E: ckr-1 (homo sapiens) (c-c moti... | [A; E; D] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: cmkbr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
B: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
D: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
E: b3 domain-containing... | [K; A; M] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
B: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
D: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
E: cc-ckr-4 (hom... | [F; H; N] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
B: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
C: lec1 (drosophila melanogaster) (aka parched)
D: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
E: ccr-8 (homo sapiens) (aka c-c mo... | [F; G; E] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
B: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
C: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
D: cc-ckr-6 (homo sapiens) (aka c-c motif... | [L; A; N] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: b1309 (escherichia coli str. k-12 substr. mg1655) (aka glucosylglycerate phosphorylase)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
D: lec-12 (caenorhabditis elegans) (aka galectin;galectin doma... | [O; N; G] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: znf309 (homo sapiens) (aka zinc finger with krab and scan domains 3)
B: i-309 (mus musculus) (aka c-c motif chemokine ligand 1)
C: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
D: b1309 (escherich... | [M; I; K] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
B: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: ib291 (xenopus tropicalis) (aka general transcription factor iii)
D: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor ... | [K; J; B] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
B: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: ib291 (xenopus tropicalis) (aka general transcription factor iii)
E: scya6 (homo sap... | [O; G; B] |
<Instruct>: Given the context 'A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination.', select the correct biomedical concept for each mention usin... | <Mentions>: [lec]
<Options>: A: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
D: lec-12 (caenorhabditis elegans) (aka galectin;galectin domain-containing protein)
E: b-lec (gallus gallus)... | [A] |
<Instruct>: Given the context 'This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec]
<Options>: A: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
C: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
D: lec3 (homo sapiens) (aka adh... | [E] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: mjdl (homo sapiens) (aka ataxin 3 like)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: mjds (homo sapiens) (aka lipin 2)
D: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
E: ataxin 3 (homo sapiens) (aka ataxin 3)
F: rad23b (ho... | [E; E; O; F] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr6b (homo sapiens) (aka ubiquitin conjugating enzyme e2 b)
B: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
E: ... | [N; N; G; P] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
B: nr3b2 (homo sapiens) (aka estrogen related receptor beta)
C: atxn3 (homo sapiens) (aka ataxin 3)
D: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
E: dnaj homolog subfamily b member 1 (... | [C; C; N; Q] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
B: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
C: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
D: hhr21 (homo sapiens) (ak... | [I; I; H; M] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: ataxin 3 (mus musculus) (aka ataxin 3)
B: mjds (homo sapiens) (aka lipin 2)
C: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: mjd1 (mus musculus) (aka ataxin 3)
F: mjdl (homo sapi... | [N; N; I; C] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [mjd1; ataxin-3]
<Options>: A: mjd1 (mus musculus) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: mjd (homo sapiens) (aka ataxin 3)
E: ataxin 3 (sus scrofa) (aka ataxin 3)
F: dnaj homolog subfamily b member 1 (cae... | [D; D] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [mjd1; ataxin-3]
<Options>: A: ataxin 3 (sus scrofa) (aka ataxin 3)
B: dnaj homolog subfamily b member 1 (caenorhabditis elegans) (aka dnaj homolog subfamily b member 1)
C: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
D: mjds (homo sapiens) (aka lipin 2)
E: ataxin-3 homolog (caenorhabditis elegans) ... | [I; I] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [mjd1; ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
C: mjd1 (homo sapiens) (aka ataxin 3)
D: ataxin 3 (sus scrofa) (aka ataxin 3)
E: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
F: dnaj homolog su... | [C; C] |
<Instruct>: Given the context 'The mutant ataxin-3 forms intranuclear inclusions in cultured cells as well as in diseased human brain and also causes cell death in transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: atx3 (homo sapiens) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'However, the normal function of ataxin-3 remains unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: atx3 (homo sapiens) (aka ataxin 3)
C: ataxin 3 (sus scrofa) (aka ataxin 3)
D: ataxin-3 (mus musculus) (aka ataxin 3)
E: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'To explore the function of ataxin-3, we used the two-hybrid system to screen for the protein(s) that interacts with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: ataxin-3 (mus musculus) (aka ataxin 3)
E: atx3 (homo sapiens) (aka ataxin 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
D: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
E: sca3 (homo s... | [E; R; H; L] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hsd3b2 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces cerev... | [E; M; R; L] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: rad23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
B: hh2r (homo sapiens) (aka histamine receptor h2)
C: rad23p (saccharomyces cerevisiae s288c) (aka rad23p)
D: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces ... | [K; C; N; A] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
D: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
E: rad23p (saccharomyces cerevisi... | [G; E; R; K] |
<Instruct>: Given the context 'Furthermore, we confirmed that ataxin-3 interacts with the -ubiquitin-like domain at the N-terminus of the HHR23 proteins, which is important for nucleotide excision repair; however, ataxin-3 does not interact with -ubiquitin, implying that ataxin-3 might be functionally associated with t... | <Mentions>: [ataxin-3]
<Options>: A: atx3 (homo sapiens) (aka ataxin 3)
B: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
C: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'The normal and mutant ataxin-3 proteins show no difference in their ability to bind to the HHR23 proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
B: ataxin 3 (homo sapiens) (aka ataxin 3)
C: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
D: ataxin 3 (sus scrofa) (aka ataxin 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [hhr23a; ataxin-3]
<Options>: A: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: atx3 (homo sapiens) (aka ataxin 3)
F: hhr21 (... | [G; E] |
<Instruct>: Given the context 'However, in 293 cells HHR23A is recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [hhr23a; ataxin-3]
<Options>: A: atx3 (homo sapiens) (aka ataxin 3)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
D: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: hh23 (homo ... | [H; A] |
<Instruct>: Given the context 'These results suggest that this interaction is associated with the normal function of ataxin-3 and that some functional abnormality of the HHR23 proteins might exist in MJD.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
C: sca3 (homo sapiens) (aka ataxin 3)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: ataxin-3 (mus musculus) (aka ataxin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual... | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: retinitis pigmentosa 6 (x-linked recessive) (homo sapiens) (aka retinitis pigmentosa 6 (x-linked recessive))
B: rs (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
C: retinal dystrophy, x-linked, garde... | [B; B; B] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual... | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: retinoschisin 1 l homeolog (xenopus laevis) (aka retinoschisin 1 l homeolog)
B: rs1 (mus musculus) (retinoschisis (x-linked, juvenile) 1 (human) (mus musculus)) (aka retinoschisis (x-linked, juvenile) 1 (human))
C: retinos... | [D; D; D] |
<Instruct>: Given the context 'Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cells.
X-linked retinoschisis is characterized by microcystic-like changes of the macular region and schisis within the inner retinal layers, leading to visual... | <Mentions>: [retinoschisin; x-linked retinoschisis protein; x-linked retinoschisis]
<Options>: A: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
B: retinoschisin 1 s homeolog (xenopus laevis) (aka retinoschisin 1 s homeolog)
C: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
D: rs1 (mus musculus) (retinoschisis ... | [J; J; J] |
<Instruct>: Given the context 'Many missense and protein-truncating mutations of the causative gene RS1 have now been identified and are thought to be inactivating.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [rs1]
<Options>: A: rs1 (homo sapiens) (retinoschisin 1 (homo sapiens)) (aka retinoschisin 1)
B: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
C: rs1 (human alphaherpesvirus 1) (transcriptional regulator icp4 (human alphaherpesvirus 1)) (aka transcri... | [A] |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (gallus gallus) (aka retinoschisin 1)
B: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
C: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
D: retinoschisin 1 (rat... | [E; E] |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
B: rs1 (homo sapiens) (regulator of solute carriers 1 (homo sapiens)) (aka regulator of solute carriers 1)
C: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
D: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
... | [I; I] |
<Instruct>: Given the context 'RS1 encodes a 224 amino acid protein, retinoschisin, which contains a discoidin domain but is of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rs1; retinoschisin]
<Options>: A: rsg1 (homo sapiens) (aka ciliogenesis and planar polarity effector complex subunit 2)
B: rsts1 (homo sapiens) (aka creb binding lysine acetyltransferase)
C: retinoschisin 1 (bos taurus) (aka retinoschisin 1)
D: rsf1 (homo sapiens) (aka remodeling and spacing factor 1)
E: r... | [E; E] |
<Instruct>: Given the context 'We have generated a polyclonal antibody against a peptide from a unique region within retinoschisin, which detects a protein of approximately 28 kDa in retinal samples reduced with dithiothreitol, but multimers sized >40 kDa under non-reducing conditions.', select the correct biomedical c... | <Mentions>: [retinoschisin]
<Options>: A: retinoschisin 1 (rattus norvegicus) (aka retinoschisin 1)
B: retinoschisin 1 (xenopus tropicalis) (aka retinoschisin 1)
C: retinoschisin 1 (homo sapiens) (aka retinoschisin 1)
D: retinoschisin 1 (sus scrofa) (aka retinoschisin 1)
E: retinoschisin 1 (gallus gallus) (aka retinosc... | [C] |
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