instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We reconstructed the haplotypes of this family with ten additional markers (five were novel) and narrowed the candidate interval to a region of < 245 kb, which contains 24 expressed sequence tags, the KIAA0958 gene and the 5' end of the COL18A1 gene.', select the correct biomedical concep... | <Mentions>: [kiaa0958; col18a1]
<Options>: A: col18a1 (mus musculus) (aka collagen, type xviii, alpha 1)
B: col18a1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
C: col18a1 (rattus norvegicus) (aka collagen type xviii alpha 1 chain)
D: chromosome 4 c11orf58 homolog (xenopus tropicalis) (aka chromosome 4 c11orf... | [K; J] |
<Instruct>: Given the context 'We identified a homozygous mutation at the AG consensus acceptor splice site of COL18A1 intron 1 exclusively among the 12 KS patients, which was not found among 140 control chromosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [col18a1]
<Options>: A: col18a1 (rattus norvegicus) (aka collagen type xviii alpha 1 chain)
B: col18a1.s (xenopus laevis) (aka collagen type xviii alpha 1 s homeolog)
C: col18a1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
D: col18a1 (mus musculus) (aka collagen, type xviii, alpha 1)
E: col18a1 (h... | [E] |
<Instruct>: Given the context 'This mutation predicts the creation of a stop codon in exon 4 and therefore the truncation of the alpha1(XVIII) collagen short form, which was expressed in human adult retina.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [alpha1(xviii) collagen]
<Options>: A: collagen type xviii alpha 1 chain (homo sapiens) (aka collagen type xviii alpha 1 chain)
B: collagen type xxviii alpha 1 chain (homo sapiens) (aka collagen type xxviii alpha 1 chain)
C: collagen type xviii alpha 1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
... | [A] |
<Instruct>: Given the context 'These findings provide evidence that KS is caused by mutations in COL18A1 which, therefore, has a major role in determining the retinal structure as well as in the closure of the neural tube.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [col18a1]
<Options>: A: col18a1 (homo sapiens) (aka collagen type xviii alpha 1 chain)
B: col18a1 (mus musculus) (aka collagen, type xviii, alpha 1)
C: col18a1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
D: col18a1 (xenopus laevis) (aka collagen type xviii alpha 1 l homeolog)
E: col18a1.s (xenopu... | [A] |
<Instruct>: Given the context 'CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: ciks (homo sapiens) (aka traf3 interacting protein 2)
B: clk (homo sapiens) (aka cdc like kinase 1)
C: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
D: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: cisk (homo sapiens) (aka serum/gluco... | [A] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
B: ikk1 (homo sapiens) (aka component of inh... | [B; K; O; O] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nemep (homo sapiens) (aka small integral membrane protein 43)
B: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
C: ntemnd (homo sapiens) (aka patatin like domain 6, lysophospholipase)
D: nemo/nlk (drosophila melanogaster) (aka nemo)
E:... | [I; G; K; K] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
B: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
C: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
D: ikka (m... | [B; A; O; O] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nemep (mus musculus) (aka small integral membrane protein 43)
B: nemo (drosophila melanogaster) (aka nemo)
C: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
D: nfkbib (homo sapiens) (aka nfk... | [H; K; C; C] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkgamma]
<Options>: A: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
B: ikki (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
C: ikkgamma (drosophila melanogaster) (aka kenny)
D: ikkg (homo sapiens) (aka inhibitor of nuclear factor... | [D] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: nemep (homo sapiens) (aka small integral membrane protein 43)
B: csk (homo sapiens) (aka c-terminal src kinase)
C: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
D: ciks (homo sapiens) (aka traf3 interacting protein 2)
E: ik... | [D; C; C] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
C: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: nemo (mus musculus) (aka inhibitor of k... | [G; H; H] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
B: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
C: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: crkas (homo sapiens) (aka b... | [L; A; A] |
<Instruct>: Given the context 'When ectopically expressed, CIKS stimulates IKK and SAPK/JNK kinases and it transactivates an NF-kappaB-dependent reporter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [ciks]
<Options>: A: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
B: csk (homo sapiens) (aka c-terminal src kinase)
C: ciks (homo sapiens) (aka traf3 interacting protein 2)
D: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
E: citk (homo sapiens) (aka citron rho-interacting serine... | [C] |
<Instruct>: Given the context 'CIKS may help to connect upstream signaling events to IKK and SAPK/JNK modules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: ciks (homo sapiens) (aka traf3 interacting protein 2)
B: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
C: clk (homo sapiens) (aka cdc like kinase 1)
D: ciks (mus musculus) (aka traf3 interacting protein 2)
E: citk (homo sapiens) (aka citron rho-interacting serine/thr... | [A] |
<Instruct>: Given the context 'CIKS could coordinate the activation of two stress-induced signaling pathways, functions reminiscent of those noted for tumor necrosis factor receptor-associated factor adaptor proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [ciks]
<Options>: A: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: clk (homo sapiens) (aka cdc like kinase 1)
C: ciks (homo sapiens) (aka traf3 interacting protein 2)
D: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
E: cik1p (saccharomyces cerevisiae s288c) (... | [C] |
<Instruct>: Given the context 'Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (mus musculus) (aka smad family member 4)
E: dpc4 (homo sapiens) (aka smad family member 4)
F: None of th... | [E] |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad4 (drosophila melanogaster) (aka medea)
C: dpc4 (homo sapiens) (aka smad family member 4)
D: smad family member 3 (mus musculus) (aka smad family member 3)
E: smad3 (homo sapiens) (aka smad family member 3)
F:... | [E; C] |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka smad family member 3)
C: smad4 (mus musculus) (aka smad family member 4)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: sm... | [B; F] |
<Instruct>: Given the context 'We investigated the functional consequences of four missense mutations in the Smad4 amino-terminal domain found in human tumors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [smad4]
<Options>: A: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
B: smad family member 4 (homo sapiens) (aka smad family member 4)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad family member 4 (mus musculus) (aka smad family member 4)
E: smad4 (drosophila melanoga... | [B] |
<Instruct>: Given the context 'We investigated the functional consequences of four missense mutations in the Smad4 amino-terminal domain found in human tumors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [smad4]
<Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: None of the above. | [E] |
<Instruct>: Given the context 'The mutant proteins were found to have impaired abilities to bind DNA although they were fully capable of forming complexes with Smad3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [smad3]
<Options>: A: smad family member 3 (mus musculus) (aka smad family member 3)
B: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
C: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
D: mad-3 (homo sapiens) (aka nfkb in... | [E] |
<Instruct>: Given the context 'All four Smad4 mutants showed decreased protein stability compared to wild-type Smad4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: smad4 (homo sapiens) (aka smad family member 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: smad4 (drosophila melanogaster)... | [B] |
<Instruct>: Given the context 'Two of the Smad4 mutants (G65V and P130S) were translocated to the nucleus and were capable of transactivating a Smad-dependent promoter in a ligand-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: dpc4 (homo sapiens) (aka smad family member 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: smad family member 4 (mus musculus) (aka smad famil... | [C] |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
D: smad4 (mus musculus) (aka smad family member 4)
E: smad4 (drosophila melanogaster) (aka me... | [H; I] |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [smad3; smad4]
<Options>: A: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
B: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
C: madh4 (homo sapiens) (aka smad family member 4)
D: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka... | [D; C] |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept for each mention ... | <Mentions>: [smad4; smad3]
<Options>: A: madh4 (homo sapiens) (aka smad family member 4)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad4 (mus musculus) (aka smad family member 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: smad family member 3 (xenopus tropicali... | [A; I] |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept for each mention ... | <Mentions>: [smad4; smad3]
<Options>: A: smad3 (mus musculus) (aka smad family member 3)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka smad family member 3)
D: smad4 (drosophila melanogaster) (aka medea)
E: mad3 (homo sapiens) (max di... | [J; C] |
<Instruct>: Given the context 'In conclusion, mutations in the amino-terminal domain of Smad4, that are found in cancer, show loss of multiple functional properties which may contribute to tumorigenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [smad4]
<Options>: A: smad4 (drosophila melanogaster) (aka medea)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: madh4 (homo sapiens) (aka smad family member 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: smad family member 4 (xenopus tropicalis) (aka smad family member ... | [C] |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; doublecortin]
<Options>: A: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
B: doublecortin (mus musculus) (aka doublecortin)
C: doublecortin domain containing 2 (xenopus tropicalis) (aka doublecortin domain containing 2)
D: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1... | [E; I] |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; doublecortin]
<Options>: A: lis1 (drosophila melanogaster) (aka lissencephaly-1)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
E: lis-... | [D; I] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: dcx (mus musculus) (aka doublecortin)
C: dcx (homo sapiens) (aka doublecortin)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: dcx (rattus norvegicus) (aka doublecortin)
F: lis1 (homo sapiens... | [F; C; F] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis1a (danio rerio) (aka platelet-activating facto... | [C; E; C] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E:... | [B; E; B] |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (xenopus tropicalis) (aka doublecortin)
B: doublecortin (rattus norvegicus) (aka doublecortin)
C: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
D: dcx (mus musculus) (aka doublecortin)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: lis1 (homo sapiens) (aka... | [F; I] |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: dcx (mus musculus) (aka doublecortin)
E: lis3 (homo sa... | [C; H] |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
C: dcx (rattus norvegicus) (aka doublecortin)
D: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
E: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
F: dcx (mus musculus) (... | [J; H] |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: dcx (homo sapiens) (aka doublecortin)
C: dcx (rattus norvegicus) (aka doublecortin)
D: dcx (oryctolagus cuniculus) (aka doublecortin)
E: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
F: doublecortin (xenopus tropica... | [B; J] |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [dcx; lis1]
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
C: lis1 (drosophila melanogaster) (aka lissencephaly-1)
D: doublecortin (rattus norvegicus) (aka doublecortin)
E: lis1 (homo sapiens) (aka platelet ... | [H; E] |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [dcx; lis1]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
C: doublecortin (homo sapiens) (aka doublecortin)
D: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b re... | [C; E] |
<Instruct>: Given the context 'In addition, we demonstrate homodimerization of DCX in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx]
<Options>: A: doublecortin (homo sapiens) (aka doublecortin)
B: doublecortin (xenopus tropicalis) (aka doublecortin)
C: dcx (oryctolagus cuniculus) (aka doublecortin)
D: doublecortin (rattus norvegicus) (aka doublecortin)
E: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
F: None of the above... | [A] |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: doublecortin (rattus norvegicus) (aka doublecortin)
C: dcx (homo sapiens) (aka doublecortin)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: dcx (oryctolagus cuniculus) (aka doublecortin)
F: lis1 (homo sapiens) (... | [F; C] |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: dcx (oryctolagus cuniculus) (aka doublecortin)
C: doublecortin (rattus norvegicus) (aka doublecortin)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: dcx (homo sapiens) (aka doublecortin)
F: doublecortin (xenopus tropicalis) ... | [J; E] |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
B: lis1 (drosophila melanogaster) (aka lissencephaly-1)
C: doublecortin (rattus norvegicus) (aka doublecortin)
D: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
E: dcxr (homo sapiens) (aka dicarbonyl and l-xylul... | [I; H] |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
B: doublecortin (homo sapiens) (aka doublecortin)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
E: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose re... | [G; B] |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
B: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
C: dcx (homo sapiens) (aka doublecortin)
D: dcx (oryctolagus cuniculus) (aka doublecortin)
E: doublecortin (rattus norvegicus) (aka doublecortin)
F: lis1 (homo ... | [F; C] |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
E: lis... | [I; B] |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
B: doublecortin (homo sapiens) (aka doublecortin)
C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
E: dcx (oryctolagus cuniculus) (aka doublecort... | [B; G] |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
D: dcx (mus musculus) (aka doublecortin)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b r... | [J; E] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [lis1; dcx]
<Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: dcx (mus musculus) (aka doublecortin)
D: doublecortin (rattus norvegicus) (aka doublecortin)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulator... | [E; G] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [lis1; dcx]
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: dcx (mus musculus) (aka doublecortin)
E: dcx (homo sapiens) (aka doublecortin)
F: dc... | [A; E] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [lis1]
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: lis1 (homo sapiens) (aka platelet activating factor a... | [E] |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (rattus norvegicus) (aka doublecortin)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: dcx (mus musculus) (aka doublecortin)
D: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
E: dcx (homo sapiens) (aka doublecortin)
F: lis3 (homo sapiens) (aka tubul... | [I; E] |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: doublecortin (xenopus tropicalis) (aka doublecortin)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
D: dcx (mus musculus) (aka doublecortin)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: dcx (oryctolagus cunic... | [G; I] |
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
D: kv4.2 (mus musculus) (aka po... | [A] |
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [kv4.2]
<Options>: A: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
B: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
D: kv4.2 (mus musculus)... | [E] |
<Instruct>: Given the context 'Immunocytochemical studies reveal a somatodendritic Kv4.2 expression pattern, with the channels concentrated mainly at dendritic spines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
C: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
D: kv9.2 (homo sapiens) (ak... | [A] |
<Instruct>: Given the context 'The molecular mechanism that underlies the localization of Kv4.2 to this subcellular region is unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
D: kv9.2 (homo sapiens) (ak... | [B] |
<Instruct>: Given the context 'We used the yeast two-hybrid system to identify the Kv4.2-associated proteins that are involved in channel localization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
D: kv6.4 (homo sapiens) (aka potassiu... | [A] |
<Instruct>: Given the context 'Here we demonstrate a direct interaction between Kv4.2 and the actin-binding protein, filamin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
D: kir4.2 (homo sapiens) (aka potassi... | [A] |
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
D: kv4.2 (rattus norv... | [B] |
<Instruct>: Given the context 'To examine the functional consequences of this interaction, we expressed Kv4.2 in filamin(+) and filamin(-) cells and performed immunocytochemical and electrophysiological analyses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
C: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
D: kv6.4 (homo sapien... | [A] |
<Instruct>: Given the context 'Our results indicate that Kv4.2 colocalizes with filamin at filopodial roots in filamin(+) cells but shows a nonspecific expression pattern in filamin(-) cells, with no localization to filopodial roots.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [kv4.2]
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
D: kv6.4 (homo sapiens) (aka pota... | [B] |
<Instruct>: Given the context 'Furthermore, the magnitude of whole-cell Kv4.2 current density is approximately 2.7-fold larger in filamin(+) cells as compared with these currents in filamin(-) cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
C: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
D: kv6.4 (homo sapiens) (aka pota... | [A] |
<Instruct>: Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', select the correct biomedical conce... | <Mentions>: [kv4.2]
<Options>: A: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
B: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
D: kv4.2 (homo sapiens)... | [D] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: dfnb109 (homo sapiens) (aka epithelial splicing regulatory protein 1)
B: entr1 (homo sapiens) (aka endosome associated trafficking regulator 1)
C: tmprss3 (danio rerio) (aka transmembrane serine protease 3b)
D: aes-1 (homo sapiens) (aka tle family member 5, tra... | [L; L; L; L] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: dfnb7 (homo sapiens) (aka transmembrane channel like 1)
B: echos1 (xenopus tropicalis) (aka transmembrane serine protease 3)
C: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20)
D: wee1 pseudogene 1 (homo sapiens) (aka wee1 pseudogene 1)
E: hypertens... | [Q; Q; Q; Q] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: dfna10 (homo sapiens) (aka eya transcriptional coactivator and phosphatase 4)
B: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
C: dfnb109 (homo sapiens) (aka epithelial splicing regulatory protein 1)
D: echos1 (xenopus laevis) (aka transmembrane ... | [N; N; N; N] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: tmprss3 (mus musculus) (aka transmembrane protease, serine 3)
B: echo virus (serotypes 4, 6, 11, 19) sensitivity (homo sapiens) (aka echo virus (serotypes 4, 6, 11, 19) sensitivity)
C: tmprss3 (homo sapiens) (transmembrane serine protease 3 (homo sapiens)) (aka... | [C; C; C; C] |
<Instruct>: Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', select the correct biomedical concept... | <Mentions>: [dfnb10]
<Options>: A: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
B: dfnb15 (homo sapiens) (aka gipc pdz domain containing family member 3)
C: dfnb9 (homo sapiens) (aka otoferlin)
D: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
E: dfn... | [A] |
<Instruct>: Given the context 'A mutation in a splice-acceptor site, resulting in a 4-bp insertion in the mRNA and a frameshift, was detected in childhood onset deafness (DFNB8).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [dfnb8]
<Options>: A: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
B: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5)
C: dfnb8 (homo sapiens) (aka transmembrane serine protease 3)
D: dfna8 (homo sapiens) (aka tectorin alpha)
E: dfnb3 (homo sapiens) (aka myosin xva)
F: None of the ... | [C] |
<Instruct>: Given the context 'A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2]
<Options>: A: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
B: palb2 (homo sapiens) (aka partner and localizer of brca2)
C: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
D: brca2, dna repair associated (droso... | [C] |
<Instruct>: Given the context 'Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2]
<Options>: A: palb2 (homo sapiens) (aka partner and localizer of brca2)
B: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
C: fancb (homo sapiens) (aka fa complementation group b)
D: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated... | [D] |
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [brca2]
<Options>: A: fancd2 (homo sapiens) (aka fa complementation group d2)
B: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
C: palb2 (homo sapiens) (aka partner and localizer of brca2)
D: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka brea... | [B] |
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [brca2]
<Options>: A: palb2 (homo sapiens) (aka partner and localizer of brca2)
B: fancd2 (homo sapiens) (aka fa complementation group d2)
C: fancb (homo sapiens) (aka fa complementation group b)
D: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 suscep... | [E] |
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [brca2-associated factor 35; braf35]
<Options>: A: formation of mitochondrial complex v assembly factor 1 homolog (xenopus tropicalis) (aka formation of mitochondrial complex v assembly factor 1 homolog)
B: braf35 (homo sapiens) (aka high mobility group 20b)
C: chromosome 6 c1orf35 homolog (xenopus tropical... | [B; B] |
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [brca2-associated factor 35; braf35]
<Options>: A: braf35 (mus musculus) (aka high mobility group 20b)
B: fam35ap (homo sapiens) (aka shieldin complex subunit 2 pseudogene 2)
C: braf25 (homo sapiens) (aka high mobility group 20b)
D: dnaaf15 (homo sapiens) (aka pih1 domain containing 2)
E: braf1 (xenopus lae... | [C; C] |
<Instruct>: Given the context 'BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [braf35]
<Options>: A: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
B: braf2 (homo sapiens) (aka braf pseudogene 1)
C: braf25 (homo sapiens) (aka high mobility group 20b)
D: braf1 (homo sapiens) (aka b-raf proto-oncogene, se... | [C] |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [brca2; braf35]
<Options>: A: fancd2 (homo sapiens) (aka fa complementation group d2)
B: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
C: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
D: brca2 (ho... | [D; H] |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [brca2; braf35]
<Options>: A: fancb (homo sapiens) (aka fa complementation group b)
B: brca2 (homo sapiens) (aka brca2 dna repair associated)
C: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
D: braf transforming gene, related sequence 1 (mus musculus) (aka braf tr... | [B; H] |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [braf35; brca2]
<Options>: A: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
B: braf35 (homo sapiens) (aka high mobility group 20b)
C: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair ass... | [B; C] |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [braf35; brca2]
<Options>: A: fancb (homo sapiens) (aka fa complementation group b)
B: braf25 (homo sapiens) (aka high mobility group 20b)
C: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
D: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast ca... | [B; F] |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [brca2; braf35]
<Options>: A: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
B: braf35 (mus musculus) (aka high mobility group 20b)
C: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus l... | [J; I] |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [brca2; braf35]
<Options>: A: braf25 (homo sapiens) (aka high mobility group 20b)
B: braf2 (homo sapiens) (aka braf pseudogene 1)
C: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
D: fancd2 (homo sapiens) (aka fa complementation group d2)
E: brca2,... | [J; A] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
B: gtx (xenopus tropicalis) (aka nk6 homeobox 2)
C: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
D: thex (xenopus laevis) (hematopoietically expressed homeobox s homeolog (xenopus laevi... | [G; A; A] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: gtx (xenopus tropicalis) (aka nk6 homeobox 2)
B: nkx6a (homo sapiens) (aka nk6 homeobox 1)
C: nkx6.2 (xenopus tropicalis) (aka nk6 homeobox 2)
D: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
E: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-... | [D; M; M] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: gta (xenopus laevis) (aka integrin subunit alpha 2b s homeolog)
B: nkx6b (homo sapiens) (aka nk6 homeobox 2)
C: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
E: nkx6.2 (xen... | [C; M; M] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
B: thex (xenopus laevis) (hematopoietically expressed homeobox s homeolog (xenopus laevis)) (aka hematopoietically expressed homeobox s homeolog)
C: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx6-3 (homo sapiens) (aka nk6 home... | [C; A; A] |
<Instruct>: Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx3b (homo sapiens) (aka nk3 homeobox 2)
B: nkx6a (homo sapiens) (aka nk6 homeobox 1)
C: nkx6b (homo sapiens) (aka nk6 homeobox 2)
D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
E: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2... | [C] |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2]
<Options>: A: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
B: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
C: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
E: nkx6.2 (xenopus tropicalis) (aka nk6 homeobox 2)
F: nkx6.2 (xenopus laevis) (nk6 h... | [C; J] |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2]
<Options>: A: nkx3b (homo sapiens) (aka nk3 homeobox 2)
B: nkx6b (homo sapiens) (aka nk6 homeobox 2)
C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
D: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
E: nkx6.2 (xenopus laevis) (nk6 homeobox ... | [G; I] |
<Instruct>: Given the context 'Northern blot experiments showed that NKX6B expression is tightly controlled in a tissue-specific fashion with the highest site of expression being the brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [nkx6b]
<Options>: A: nkx6b (homo sapiens) (aka nk6 homeobox 2)
B: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
D: nkx6a (homo sapiens) (aka nk... | [A] |
<Instruct>: Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [nkx6b]
<Options>: A: nkx6a (homo sapiens) (aka nk6 homeobox 1)
B: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2)
C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
D: nkx6b (homo sapiens) (aka nk6 homeobox 2)
E: nkx3b (homo sapiens) (aka nk3 homeobox 2)... | [D] |
<Instruct>: Given the context 'These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [nkx6b]
<Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
B: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
C: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx6a (homo sapiens) (aka n... | [C] |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd58; cd2]
<Options>: A: cd5 molecule (homo sapiens) (aka cd5 molecule)
B: cd58 (homo sapiens) (aka cd58 molecule)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
E: cd52 molecule (homo sapiens) (aka cd52 molec... | [B; H] |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd58; cd2]
<Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd228 (homo sapiens) (aka melanotransferrin)
D: cd58 molecule (homo sapiens) (aka cd58 molecule)
E: cd5 (homo sapiens) (aka cd5 molecule)
F: cd22 (homo sapiens) (ak... | [D; J] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd4 molecule (homo sapiens) (aka cd4 molecule)
B: cd22 (homo sapiens) (aka cd22 molecule)
C: integrin subunit beta 4 (homo sapiens) (aka integrin subunit beta 4)
D: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
E: cd4 (gallus gallus) (a... | [A; G; J] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd4 molecule (homo sapiens) (aka cd4 molecule)
B: gp4 (homo sapiens) (aka cd36 molecule (cd36 blood group))
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
E: cd... | [A; N; J] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: hm4 (homo sapiens) (aka cholinergic receptor muscarinic 4)
B: cd5 (homo sapiens) (aka cd5 molecule)
C: cd2 (homo sapiens) (aka cd2 molecule)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: cd4 (gallus gallus) (aka cd4 molecule)
F: cd2 (gallus gallus) (aka cd2 molecule)
G: cd57 (... | [J; I; C] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: il2 (homo sapiens) (aka interleukin 2)
B: il22 (homo sapiens) (aka interleukin 22)
C: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
D: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
E: fosb proto-oncogene, ap-1 transcription fa... | [C; G; A] |
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