instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: polynucleotide kinase 3'-phosphatase (bos taurus) (aka polynucleotide kinase 3'-phosphatase)
B: polynucleotide kinase 3'-phosphatase (homo sapiens) (aka polynucleotide kinase 3'-phosphatase)
C: xrcc9 (homo sapiens) (a... | [K; B; S; T] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [dna ligase iii]
<Options>: A: ligase iv, dna, atp-dependent (xenopus tropicalis) (aka ligase iv, dna, atp-dependent)
B: ligase iii, dna, atp-dependent (mus musculus) (aka ligase iii, dna, atp-dependent)
C: ligase iv, dna, atp-dependent (danio rerio) (aka ligase iv, dna, atp-dependent)
D: dna ligase 1 (homo... | [E] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: oohe (homo sapiens) (aka unc-45 myosin chaperone a)
B: xrcc9 (homo sapiens) (aka fa complementation group g)
C: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
D: eay (drosophila melanogaster) (early (drosophila melanogaster)) ... | [H; J; H] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
B: aprataxin-like (arabidopsis thaliana) (aka aprataxin-like protein)
C: xrcc1 (xenopus laevis) (x-ray repair complementing defective repair in chinese hamster cells 1 l homeolog (x... | [E; K; E] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
B: aprataxin (homo sapiens) (aka aprataxin)
C: xrcc1 (xenopus laevis) (x-ray repair complementing defective repair in chinese hamster cells 1 l homeolog (xenopus laevis)) (aka x-ray... | [B; E; B] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: xrcc1 (xenopus laevis) (x-ray repair complementing defective repair in chinese hamster cells 1 l homeolog (xenopus laevis)) (aka x-ray repair complementing defective repair in chinese hamster cells 1 l homeolog)
B: xrcc1 (oryctolagus cuniculus) (aka x-ray repair cross ... | [N; G; N] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: uqcc (homo sapiens) (aka ubiquinol-cytochrome c reductase complex assembly factor 1)
B: casp9 (homo sapiens) (aka caspase 9)
C: caspase 8 (homo sapiens) (aka caspase 8)
D: cytochrome c, somatic (homo sapiens) (aka cytochrome c, somatic)
E: succinate dehydrogen... | [J; D; B] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: casp-7 (homo sapiens) (aka caspase 7)
B: cytochrome c1 (homo sapiens) (aka cytochrome c1)
C: casp-8 (homo sapiens) (aka caspase 8)
D: apaf-3 (homo sapiens) (aka caspase 9)
E: apak (homo sapiens) (aka zinc finger protein 420)
F: succinate dehydrogenase complex ... | [L; G; J] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: apaf3 (homo sapiens) (aka caspase 9)
C: succinate dehydrogenase complex subunit c (homo sapiens) (aka succinate dehydrogenase complex subunit c)
D: caspase-9 (mus musculus) (aka caspase 9)
E: cytochrome c, testis-specif... | [I; K; H] |
<Instruct>: Given the context 'It has been shown that epigenetic silencing of the APAF-1 gene is a common event in several metastatic melanoma cells in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [apaf-1]
<Options>: A: apaf-3 (homo sapiens) (aka caspase 9)
B: apa-1 (homo sapiens) (aka zinc finger protein 410)
C: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
D: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
E: apaf-1 (xenopus tropicalis) (aka apoptot... | [D] |
<Instruct>: Given the context 'It has been shown that epigenetic silencing of the APAF-1 gene is a common event in several metastatic melanoma cells in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
C: apaf-3 (homo sapiens) (aka caspase 9)
D: apa-1 (homo sapiens) (aka zinc finger protein 410)
E: None of the above. | [E] |
<Instruct>: Given the context 'We determined, by Western blot, variation in the level of expression of APAF-1 in several human melanoma cell lines and, by immunohistochemistry, in a group of 106 histological samples including benign and malignant melanocytic lesions.', select the correct biomedical concept for each men... | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apak (homo sapiens) (aka zinc finger protein 420)
C: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
D: apa1 (homo sapiens) (aka zinc finger protein 410)
E: apaf-3 (homo sapiens) (aka casp... | [A] |
<Instruct>: Given the context 'We observed APAF-1 down-regulation or loss of expression in two metastatic melanoma cell lines, compared to primary melanoma cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [apaf-1]
<Options>: A: apaf3 (homo sapiens) (aka caspase 9)
B: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
C: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
D: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activati... | [C] |
<Instruct>: Given the context 'The immunohistochemical analysis revealed a significant difference in APAF-1 staining between nevi and melanomas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
B: apaf3 (homo sapiens) (aka caspase 9)
C: apak (homo sapiens) (aka zinc finger protein 420)
D: apa-1 (homo sapiens) (aka zinc finger protein 410)
E: apaf1 (homo sapiens) (aka apoptotic peptidase activating fact... | [E] |
<Instruct>: Given the context 'In addition, we found a significant negative correlation between APAF-1 expression level and tumor thickness and between primary melanomas and metastases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [apaf-1]
<Options>: A: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apa-1 (homo sapiens) (aka zinc finger protein 410)
C: apaf-3 (homo sapiens) (aka caspase 9)
D: apak (homo sapiens) (aka zinc finger protein 420)
E: apaf-1 (xenopus tropicalis) (aka ... | [A] |
<Instruct>: Given the context 'We conclude that loss of APAF-1 expression can be considered as an indicator of malignant transformation in melanoma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
B: apaf-3 (homo sapiens) (aka caspase 9)
C: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
D: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-re... | [C] |
<Instruct>: Given the context 'A human cDNA was cloned that encodes a DNA-binding protein (SATB1) that is expressed predominantly in thymus and binds selectively to the nuclear matrix/scaffold-associating DNAs (MARs/SARs).', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [satb1]
<Options>: A: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
B: satb1 (rattus norvegicus) (aka satb homeobox 1)
C: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
D: satb1 (bos taurus) (aka satb homeobox 1)
E: satb1 (sus scrofa) (aka satb homeobox 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Missing nucleoside experiments showed that SATB1 selectively binds in a special AT-rich sequence context where one strand consists of mixed A's, T's, and C's, excluding G's (ATC sequences).', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [satb1]
<Options>: A: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
B: satb2 (bos taurus) (aka satb homeobox 2)
C: satb1 (rattus norvegicus) (aka satb homeobox 1)
D: satb1 (sus scrofa) (aka satb homeobox 1)
E: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
F: None of the above. | [E] |
<Instruct>: Given the context 'When this feature is destroyed by mutation, SATB1 binding is greatly reduced even if the direct contact sequence remains intact.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [satb1]
<Options>: A: satb1 (sus scrofa) (aka satb homeobox 1)
B: satb1 (homo sapiens) (aka satb homeobox 1)
C: satb2 (bos taurus) (aka satb homeobox 2)
D: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
E: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
F... | [B] |
<Instruct>: Given the context 'Conjunctional SATB1-binding sequences become stably unpaired in supercoiled DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
B: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
C: satb1 (sus scrofa) (aka satb homeobox 1)
D: satb2 (bos taurus) (aka satb homeobox 2)
E: satb1 (bos taurus) (aka satb homeobox 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Specific mutations that diminish the unwinding potential greatly reduce SATB1 binding.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 (sus scrofa) (aka satb homeobox 1)
B: satb2 (bos taurus) (aka satb homeobox 2)
C: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
D: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
E: satb1 (rattus norvegicus) (aka satb homeobox 1)
F: None of... | [C] |
<Instruct>: Given the context 'Specific mutations that diminish the unwinding potential greatly reduce SATB1 binding.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 (sus scrofa) (aka satb homeobox 1)
B: satb1 (rattus norvegicus) (aka satb homeobox 1)
C: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
D: satb2 (bos taurus) (aka satb homeobox 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'However, SATB1 does not bind single-stranded DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 (rattus norvegicus) (aka satb homeobox 1)
B: satb1 (sus scrofa) (aka satb homeobox 1)
C: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
D: satb1 (bos taurus) (aka satb homeobox 1)
E: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
F: None of... | [C] |
<Instruct>: Given the context 'Chemical interference assays show that SATB1 binds along the minor groove with very little contact with the bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 (rattus norvegicus) (aka satb homeobox 1)
B: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
C: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
D: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
E: satb1 (sus scrofa) (aka satb homeobox 1)
... | [B] |
<Instruct>: Given the context 'This suggests that SATB1 recognizes the ATC sequence indirectly through the altered sugar-phosphate backbone structure present in the double-stranded DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [satb1]
<Options>: A: satb1 (sus scrofa) (aka satb homeobox 1)
B: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
C: satb1 (homo sapiens) (aka satb homeobox 1)
D: satb1 (rattus norvegicus) (aka satb homeobox 1)
E: satb2 (bos taurus) (aka satb homeobox 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'Cloning and characterization of a human angiotensin II type 1 receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [angiotensin ii type 1 receptor]
<Options>: A: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
B: angiotensin ii receptor type 1 (homo sapiens) (aka angiotensin ii receptor type 1)
C: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1... | [B] |
<Instruct>: Given the context 'A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 angiotensin ii receptor]
<Options>: A: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
B: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
C: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii recepto... | [B] |
<Instruct>: Given the context 'Ligand binding studies of the cloned receptor expressed in COS cells suggested that it is pharmacologically a type 1 angiotensin II receptor subtype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [type 1 angiotensin ii receptor]
<Options>: A: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
B: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
C: at2r1 (homo sapiens) (aka angiotensin ii receptor type 1)
D: angiotensin ii rece... | [C] |
<Instruct>: Given the context 'A gene encoding a putative human RNA helicase, p54, has been cloned and mapped to the band q23.3 of chromosome 11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p54]
<Options>: A: p64h1 (homo sapiens) (aka chloride intracellular channel 4)
B: d54 (homo sapiens) (aka tpd52 like 2)
C: p54 (homo sapiens) (fkbp prolyl isomerase 5 (homo sapiens)) (aka fkbp prolyl isomerase 5)
D: p54h (xenopus tropicalis) (aka dead-box helicase 6)
E: t54 (homo sapiens) (aka g-patch doma... | [F] |
<Instruct>: Given the context 'The predicted amino acid sequence shares a striking homology (75% identical) with the female germline-specific RNA helicase ME31B gene of Drosophila.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [me31b]
<Options>: A: sec31b (mus musculus) (aka sec31 homolog b, copii coat complex component)
B: tmem132b (mus musculus) (aka transmembrane protein 132b)
C: me31b (drosophila melanogaster) (aka maternal expression at 31b)
D: krt33b (mus musculus) (aka keratin 33b)
E: me31b (xenopus tropicalis) (aka dead-b... | [C] |
<Instruct>: Given the context 'Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.', select the correct biomedical concept for each mention using th... | <Mentions>: [me31b]
<Options>: A: tmem132b (mus musculus) (aka transmembrane protein 132b)
B: sec31b (mus musculus) (aka sec31 homolog b, copii coat complex component)
C: maternal expression at 31b (drosophila melanogaster) (aka maternal expression at 31b)
D: krt33b (mus musculus) (aka keratin 33b)
E: mg33b (mus muscul... | [C] |
<Instruct>: Given the context 'Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [n-myc]
<Options>: A: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
... | [D] |
<Instruct>: Given the context 'Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [n-myc]
<Options>: A: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)... | [E] |
<Instruct>: Given the context 'The gene termed heir-1 was localized to the neuroblastoma consensus deletion at 1p36.2-p36.12.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heir-1]
<Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
C: hef1 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
D: heir-1 (xenopus laevis) (inhibitor of dna binding 3... | [A] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: iddam (homo sapiens) (aka chromodomain helicase dna binding protein 8)
B: iddpn (homo sapiens) (aka nudix hydrolase 2)
C: hlh462 (mus musculus) (aka inhibitor of dna binding 3)
D: id (mus musculus) (aka atpase, class i, type 8b, member 2)
E: lethal (2) 46eh (drosophila melano... | [C; D; K] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: lethal (1) hm442 (drosophila melanogaster) (aka lethal (1) hm442)
B: er membrane complex subunit emc3 (saccharomyces cerevisiae s288c) (aka er membrane complex subunit emc3)
C: id1 (homo sapiens) (aka inhibitor of dna binding 1)
D: hlh462 (mus musculus) (aka inhibitor of dna ... | [D; G; F] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: id (mus musculus) (aka atpase, class i, type 8b, member 2)
B: zfp462 (xenopus laevis) (zinc finger protein 462 s homeolog (xenopus laevis)) (aka zinc finger protein 462 s homeolog)
C: ids (homo sapiens) (aka iduronate 2-sulfatase)
D: emc (drosophila melanogaster) (aka extra m... | [M; A; D] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: vista enhancer hs472 (homo sapiens) (aka vista enhancer hs472)
B: hlh462 (mus musculus) (aka inhibitor of dna binding 3)
C: id (mus musculus) (aka atpase, class i, type 8b, member 2)
D: zfp462 (xenopus laevis) (zinc finger protein 462 s homeolog (xenopus laevis)) (aka zinc fi... | [B; C; O] |
<Instruct>: Given the context 'Heir-1 does not encode a basic DNA binding domain as found in basic HLH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heir-1]
<Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: hef1 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
C: heew1 (homo sapiens) (aka ectopic p-granules 5 autophagy tethering factor)
D: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
E: h... | [A] |
<Instruct>: Given the context 'Despite prominent heir-1 expression in adrenal medulla, which is a prime target for neuroblastomas, 10 out of 12 neuroblastoma-derived cell lines revealed very low levels of heir-1 mRNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [heir-1]
<Options>: A: hef1 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
B: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
C: heir-1 (xenopus laevis) (inhibitor of dna binding 3, hlh protein l homeolog (xenopus laevis)) (aka inhibitor of dna binding 3, hlh p... | [B] |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [heir-1; n-myc]
<Options>: A: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
B: heir-1 (xenopus laevis) (inhibitor of dna binding 3, hlh protein l homeolog (xenopus laevis)) (aka inhib... | [H; I] |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [heir-1; n-myc]
<Options>: A: heed (homo sapiens) (aka embryonic ectoderm development)
B: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
C: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
D: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-... | [B; F] |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [heir-1; n-myc]
<Options>: A: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
B: hin-1 (homo sapiens) (aka secretoglobin family 3a member 1)
C: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
D: n-myc (homo sapiens) (aka mycn proto-oncogene, bhlh transc... | [E; D] |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [heir-1; n-myc]
<Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: v-myc avian myelocytomatosis viral oncogene ne... | [A; H] |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [heir-1; n-myc]
<Options>: A: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
B: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
C: hrt-1 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 1)
D: heir-1 (xenopus laevis) (inhibitor of dna bind... | [B; J] |
<Instruct>: Given the context 'Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hnrnp u]
<Options>: A: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
B: heterogeneous nuclear ribonucleoprotein u (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnpu (bos tau... | [B] |
<Instruct>: Given the context 'The hnRNP U protein is an abundant nucleoplasmic phosphoprotein that is the largest of the major hnRNP proteins (120 kDa by SDS-PAGE).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: heterogeneous nuclear ribonucleoprotein u (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnpu (xenopus tropicalis) (aka... | [B] |
<Instruct>: Given the context 'HnRNP U binds pre-mRNA in vivo and binds both RNA and ssDNA in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
B: heterogeneous nuclear ribonucleoprotein u (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a)... | [B] |
<Instruct>: Given the context 'Here we describe the cloning and sequencing of a cDNA encoding the hnRNP U protein, the determination of its amino acid sequence and the delineation of a region in this protein that confers RNA binding.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
C: heterogeneous nuclear ribonucleoprotein u (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnpu (xenopus t... | [E] |
<Instruct>: Given the context 'The predicted amino acid sequence of hnRNP U contains 806 amino acids (88,939 Daltons), and shows no extensive homology to any known proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hnrnp u]
<Options>: A: hnrpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleopro... | [A] |
<Instruct>: Given the context 'Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [cytoskeletal protein 4.1]
<Options>: A: erythrocyte membrane protein band 4.1-like 1 (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1-like 1)
B: erythrocyte membrane protein band 4.1 like 1 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 1)
C: erythrocyte membrane protein band... | [E] |
<Instruct>: Given the context 'We screened human megakaryoblastic cell line (MEG-01) an umbilical vein endothelial cell cDNA libraries to obtain a 3.7-kilobase cDNA designated PTPase MEG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [ptpase meg]
<Options>: A: ptp-pest (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 12)
B: ptpmeg1 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 4)
C: meg (drosophila melanogaster) (protein tyrosine phosphatase meg (drosophila melanogaster)) (aka protein tyrosine pho... | [B] |
<Instruct>: Given the context 'PTPase MEG cDNA contains an open reading frame of 926 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ptpase meg]
<Options>: A: ptpmeg (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 4)
B: pgp (mus musculus) (phosphoglycolate phosphatase (mus musculus)) (aka phosphoglycolate phosphatase)
C: protein tyrosine phosphatase meg (drosophila melanogaster) (aka protein tyrosine phosphatase meg)
... | [A] |
<Instruct>: Given the context 'The amino-terminal region (amino acids 31-367) is 45% identical to the amino terminus of human erythrocyte protein 4.1, a cytoskeletal protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [erythrocyte protein 4.1]
<Options>: A: erythrocyte membrane protein band 4.1 like 4a (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 4a)
B: erythrocyte membrane protein band 4.1 (homo sapiens) (aka erythrocyte membrane protein band 4.1)
C: erythrocyte membrane protein band 4.1 like 1 (homo s... | [B] |
<Instruct>: Given the context 'The receptor for ciliary neurotrophic factor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor]
<Options>: A: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (homo s... | [C] |
<Instruct>: Given the context 'The receptor for ciliary neurotrophic factor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor]
<Options>: A: ckr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
B: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (mus musculus) (aka ciliary neurotrophic factor re... | [E] |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor; cntf]
<Options>: A: cellular communication network factor 1 (homo sapiens) (aka cellular communication network factor 1)
B: ciliary neurotrophic factor receptor (sus scrofa) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor (homo sapiens) (a... | [E; C] |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor; cntf]
<Options>: A: cntf (bos taurus) (aka ciliary neurotrophic factor)
B: cnt1 (homo sapiens) (aka solute carrier family 28 member 1)
C: cellular communication network factor 1 (homo sapiens) (aka cellular communication network factor 1)
D: ciliary neurotrophic fa... | [I; F] |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [cntf receptor; interleukin-6]
<Options>: A: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: cntfr (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
D: ciliary neurotrophic factor receptor (homo sapiens) (aka cil... | [D; A] |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [cntf receptor; interleukin-6]
<Options>: A: npffr1 (rattus norvegicus) (aka neuropeptide ff receptor 1)
B: cntfr (homo sapiens) (aka ciliary neurotrophic factor receptor)
C: il7 (homo sapiens) (aka interleukin 7)
D: cdf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
E: cdf (homo sapiens)... | [B; D] |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [cntf receptor; interleukin-6 receptor]
<Options>: A: ciliary neurotrophic factor receptor (danio rerio) (aka ciliary neurotrophic factor receptor)
B: cntfr-alpha (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
C: interleukin 6 cytokine family signal transducer (homo sapiens) (aka interleukin... | [D; E] |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [cntf receptor; interleukin-6 receptor]
<Options>: A: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
B: cntfr-alpha (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
C: npffr1 (rattus norvegicus) (aka neuropeptide ff receptor 1)
D: cntfr (ho... | [D; H] |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [cntf receptor; interleukin-6 receptor]
<Options>: A: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
B: gp130 (homo sapiens) (interleukin 6 cytokine family signal transducer (homo sapiens)) (aka interleukin 6 cytokine family signal transducer)
C: cntfr (homo sapiens) (aka ciliary neurotrophic factor rece... | [C; G] |
<Instruct>: Given the context 'In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [cntf receptor]
<Options>: A: ciliary neurotrophic factor receptor (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (homo sapiens) (aka ciliary neurotrophic factor receptor)
C: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
D: npffr1 (rattus norvegicu... | [B] |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cellular retinol-binding protein type ii; rxr]
<Options>: A: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
B: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
C: rxrc (homo sapiens) (aka retinoid x re... | [E; D] |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cellular retinol-binding protein type ii; rxr]
<Options>: A: retinol binding protein 5 (homo sapiens) (aka retinol binding protein 5)
B: rxrg (homo sapiens) (aka retinoid x receptor gamma)
C: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid bindi... | [D; E] |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [retinoid x receptor; rxr]
<Options>: A: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
B: retinoid x receptor gamma (homo sapiens) (aka retinoid x receptor gamma)
C: lxra (homo sapiens) (aka nuclear receptor subfamily 1 group h member 3)
D: rxrbeta (homo sapiens) (aka retinoid x receptor beta)
E: r... | [G; G] |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [retinoid x receptor; rxr]
<Options>: A: retinoid x receptor gamma (homo sapiens) (aka retinoid x receptor gamma)
B: rxr-beta (homo sapiens) (aka retinoid x receptor beta)
C: rxr-alpha (homo sapiens) (aka retinoid x receptor alpha)
D: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
... | [C; C] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: crbpiii (homo sapiens) (aka retinol binding protein 5)
B: rbp2 (homo sapiens) (retinol binding protein 2 (homo sapiens)) (aka retinol binding protein 2)
C: crbpiv (homo sapiens) (aka retinol binding protein 7)
D: retinol binding protein 3... | [B; B; I] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
B: retinol binding protein 7 (homo sapiens) (aka retinol binding protein 7)
C: retinol binding protein 2 (xenopus tropicalis) (aka retinol binding protein 2)
D: rxrb... | [M; M; F] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: retinol binding protein 5 (homo sapiens) (aka retinol binding protein 5)
B: retinol binding protein 1 (homo sapiens) (aka retinol binding protein 1)
C: rxrg (homo sapiens) (aka retinoid x receptor gamma)
D: retinol binding protein 3 (homo... | [E; E; H] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: retinol binding protein 3 (homo sapiens) (aka retinol binding protein 3)
B: crbpiii (homo sapiens) (aka retinol binding protein 5)
C: rxrg (homo sapiens) (aka retinoid x receptor gamma)
D: crabp-ii (homo sapiens) (cellular retinoic acid b... | [M; M; G] |
<Instruct>: Given the context 'This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [crbpii]
<Options>: A: crbpiv (homo sapiens) (aka retinol binding protein 7)
B: crbpii (homo sapiens) (aka retinol binding protein 2)
C: crbpiii (homo sapiens) (aka retinol binding protein 5)
D: crbp (homo sapiens) (aka retinol binding protein 1)
E: crabp-ii (homo sapiens) (cellular retinoic acid binding pr... | [B] |
<Instruct>: Given the context 'The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [rxr]
<Options>: A: rxralpha (homo sapiens) (aka retinoid x receptor alpha)
B: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
C: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
D: rxrb (homo sapiens) (aka retinoid x receptor beta)
E: rxrc (homo sapiens) (aka retinoid x recep... | [A] |
<Instruct>: Given the context 'We have isolated a mouse cDNA of 5.7 kb, encoding a new member of the family of receptor-like protein tyrosine phosphatases, termed mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [mrptp mu]
<Options>: A: lmptp (mus musculus) (aka acid phosphatase 1, soluble)
B: r-ptp-mu (homo sapiens) (aka protein tyrosine phosphatase receptor type m)
C: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
D: p-ptp-mu (xenopus tropicalis) (aka protein tyrosine phosphatase, receptor type m)... | [E] |
<Instruct>: Given the context 'In addition, we have cloned the human homologue, hRPTP mu, which shows 98.7% amino acid identity to mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrptp mu; mrptp mu]
<Options>: A: mrptprho (mus musculus) (aka protein tyrosine phosphatase receptor type t)
B: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
C: trna proline, mitochondrial (mus musculus) (aka trna proline, mitochondrial)
D: mtrpol (mus musculus) (aka polymerase (... | [G; B] |
<Instruct>: Given the context 'In addition, we have cloned the human homologue, hRPTP mu, which shows 98.7% amino acid identity to mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrptp mu; mrptp mu]
<Options>: A: p-ptp-mu (xenopus tropicalis) (aka protein tyrosine phosphatase, receptor type m)
B: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
C: mrptprho (mus musculus) (aka protein tyrosine phosphatase receptor type t)
D: mtrpol (mus musculus) (aka polymer... | [G; B] |
<Instruct>: Given the context 'The predicted mRPTP mu protein consists of a 722 amino acid extracellular region, containing 13 potential N-glycosylation sites, a single transmembrane domain and a 688 amino acid intracellular part containing 2 tandem repeats homologous to the catalytic domains of other tyrosine phosphat... | <Mentions>: [mrptp mu]
<Options>: A: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
B: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
C: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
D: lmptp (mus musculus) (aka acid phosphatase 1, soluble)
E: p-ptp-... | [C] |
<Instruct>: Given the context 'Transfection of the mRPTP mu cDNA into COS cells results in the synthesis of a protein with an apparent Mr of 195,000, as detected in immunoblots using an antipeptide antibody.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [mrptp mu]
<Options>: A: mrptprho (mus musculus) (aka protein tyrosine phosphatase receptor type t)
B: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
C: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
D: trna proline, mitochondrial (mus musculus) (aka trna proline, ... | [E] |
<Instruct>: Given the context 'The human RPTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in human cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [rptp mu]
<Options>: A: protein tyrosine phosphatase receptor type u (mus musculus) (aka protein tyrosine phosphatase receptor type u)
B: rptpu (homo sapiens) (aka protein tyrosine phosphatase receptor type m)
C: protein tyrosine phosphatase receptor type u (homo sapiens) (aka protein tyrosine phosphatase r... | [B] |
<Instruct>: Given the context 'The human RPTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in human cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [rptp mu]
<Options>: A: protein tyrosine phosphatase receptor type u (mus musculus) (aka protein tyrosine phosphatase receptor type u)
B: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
C: rptpalpha (mus musculus) (aka protein tyrosine phosphatase receptor type a)
D: protein tyrosin... | [E] |
<Instruct>: Given the context 'Cytotoxic lymphocyte maturation factor (CLMF) is a disulfide-bonded heterodimeric lymphokine that (i) acts as a growth factor for activated T cells independent of interleukin 2 and (ii) synergizes with suboptimal concentrations of interleukin 2 to induce lymphokine-activated killer cells.... | <Mentions>: [interleukin 2]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
C: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
D: interleukin 2 (homo sapiens) (aka interleukin 2)
E: interleukin 3 (homo sapiens... | [D] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: kit ligand (homo sapiens) (aka kit ligand)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: g protein-coupled receptor 45 (oryctolagus cuniculus) (aka g protein-coupled receptor 45)
D: bcgf-1 (homo sapiens) (aka interleukin 4)
E: bcmo1 (homo sapiens) (aka beta-carotene oxyge... | [I; I; I] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
B: kit ligand (homo sapiens) (aka kit ligand)
C: or4c45 (homo sapiens) (aka olfactory receptor family 4 subfamily c member 45 (gene/pseudogene))
D: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
E: g prote... | [M; M; M] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: g protein-coupled receptor 45 (oryctolagus cuniculus) (aka g protein-coupled receptor 45)
B: hcpeb-1 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
C: gpr45 (homo sapiens) (aka g protein-coupled receptor 45)
D: g protein-coupled receptor 45 (ra... | [N; N; N] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: gpr45 (homo sapiens) (aka g protein-coupled receptor 45)
B: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: blast-2 (homo sapiens) (aka fc epsilon receptor ii)
D: g protein-coupled receptor 45 (rattus norvegicus) (aka g protein... | [N; N; N] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: cd22 (homo sapiens) (aka cd22 molecule)
D: cd2 molecule (bos taurus) (aka cd2 molecule)
E: cd2 molecule (homo sapiens) (aka cd2 molecule)
F: leu-3 (homo sapien... | [B; E; O] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: cd22 (homo sapiens) (aka cd22 molecule)
B: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: itga3 (homo sapiens) (aka integrin subunit alpha 3)
E: cd11a (homo sapiens) (aka inte... | [I; O; M] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: bcm1 (homo sapiens) (aka cd48 molecule)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: leu-3 (homo sapiens) (aka cd4 molecule)
D: lfa1a (homo sapiens) (aka integrin subunit alpha l)
E: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
F: lfa3 (homo sapiens) (aka... | [A; M; F] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: bcgf-1 (homo sapiens) (aka interleukin 4)
B: bcm1 (mus musculus) (aka cd48 antigen)
C: g protein-coupled receptor 45 (rattus norvegicus) (aka g protein-coupled receptor 45)
D: of45 (rattus norvegicus) (aka matrix extracellular phosphoglycoprotein)
E: hcpeb-1 (homo sapiens... | [B; B; M] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: of45 (rattus norvegicus) (aka matrix extracellular phosphoglycoprotein)
B: blast (homo sapiens) (aka cd48 molecule)
C: kit ligand (homo sapiens) (aka kit ligand)
D: bm-001 (homo sapiens) (aka cyclin l1)
E: blast-1 (mus musculus) (aka cd48 antigen)
F: bcms1 (homo sapiens) ... | [L; L; B] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: bcm1 (mus musculus) (aka cd48 antigen)
B: bm-001 (homo sapiens) (aka cyclin l1)
C: bsf-1 (homo sapiens) (aka interleukin 4)
D: kit ligand (homo sapiens) (aka kit ligand)
E: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
F: g protein-coupled receptor 45 (rattu... | [A; A; H] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [lfa3; cd2]
<Options>: A: leu-3 (homo sapiens) (aka cd4 molecule)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: itga3 (homo sapiens) (aka integrin subunit alpha 3)
D: cd2 (gallus gallus) (aka cd2 molecule)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: lfa3 (homo sapiens) ... | [F; J] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [lfa3; cd2]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: cd2 (gallus gallus) (aka cd2 molecule)
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
E: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka... | [J; G] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [lfa3; cd2]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: leu-3 (homo sapiens) (aka cd4 molecule)
D: cd2 (gallus gallus) (aka cd2 molecule)
E: cd22 molecule (homo sapiens) (aka cd22 molecule)
F: lfa3 (homo sapiens) (aka cd58 ... | [F; A] |
<Instruct>: Given the context 'Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol anchor, as is the case for rat and human BCM1 antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1]
<Options>: A: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: bcrm1 (homo sapiens) (aka sideroflexin 4)
D: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
E: bcm (homo sapiens) (aka tnf receptor superf... | [B] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
B: bcrm1 (homo sapiens) (aka sideroflexin 4)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: atpa-3 (mus musculus) (aka atpase, na+/k+ transporting, alpha 2 polypeptide)
... | [L; L; D] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: bcm1 (mus musculus) (aka cd48 antigen)
B: atpa-3 (mus musculus) (aka atpase, na+/k+ transporting, alpha 2 polypeptide)
C: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
D: atp1a3 (homo sapiens) (aka atpase na+/k+ transporting subunit a... | [A; A; B] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
D: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
E: bcrm1 (homo sapiens) (ak... | [A; A; N] |
<Instruct>: Given the context 'A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcm1; atp1a2]
<Options>: A: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
B: atp1a2 (rattus norvegicus) (aka atpase na+/k+ transporting subunit alpha 2)
C: atp2a1 (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1)
D: bcrm1 (homo sapiens) (aka sideroflexin 4)
E:... | [J; G] |
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