instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [erd2; kdel receptor]
<Options>: A: erdj2 (homo sapiens) (aka sec63 protein translocation regulator)
B: kdel endoplasmic reticulum protein retention receptor 2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
C: kdelr3 (homo sapiens) (aka kdel endoplasmic reticulum protein retent... | [D; D] |
<Instruct>: Given the context 'Primary structure and functional expression of rat and human stem cell factor DNAs.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor]
<Options>: A: gmcsf (homo sapiens) (aka colony stimulating factor 2)
B: scf (homo sapiens) (aka kit ligand)
C: il-7 (homo sapiens) (interleukin 7 (homo sapiens)) (aka interleukin 7)
D: csf1 (homo sapiens) (aka colony stimulating factor 1)
E: c-kit (homo sapiens) (aka kit proto-oncogene, r... | [B] |
<Instruct>: Given the context 'Primary structure and functional expression of rat and human stem cell factor DNAs.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor]
<Options>: A: csf1 (homo sapiens) (aka colony stimulating factor 1)
B: il-7 (homo sapiens) (interleukin 7 (homo sapiens)) (aka interleukin 7)
C: gmcsf (homo sapiens) (aka colony stimulating factor 2)
D: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
E: None of the... | [E] |
<Instruct>: Given the context 'Partial cDNA and genomic clones of rat stem cell factor (SCF) have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor; scf]
<Options>: A: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
B: interleukin 7 (homo sapiens) (aka interleukin 7)
C: csf-1 (homo sapiens) (aka colony stimulating factor 1)
D: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
E: ... | [J; J] |
<Instruct>: Given the context 'Partial cDNA and genomic clones of rat stem cell factor (SCF) have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor; scf]
<Options>: A: gmcsf (homo sapiens) (aka colony stimulating factor 2)
B: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
C: csf-1 (homo sapiens) (aka colony stimulating factor 1)
D: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
E:... | [I; I] |
<Instruct>: Given the context 'Using probes based on the rat sequence, partial and full-length cDNA and genomic clones of human SCF have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [scf]
<Options>: A: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
B: scf (homo sapiens) (aka kit ligand)
C: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
D: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
E: None of t... | [B] |
<Instruct>: Given the context 'SCF is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow cultures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [scf]
<Options>: A: csf3 (homo sapiens) (aka colony stimulating factor 3)
B: kit ligand (homo sapiens) (aka kit ligand)
C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
D: csf1 (homo sapiens) (aka colony stimulating factor 1)
E: None of the above. | [B] |
<Instruct>: Given the context 'SCF exhibits potent synergistic activities in conjunction with colony-stimulating factors, resulting in increased colony numbers and colony size.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [scf]
<Options>: A: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
B: csf3 (homo sapiens) (aka colony stimulating factor 3)
C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
D: sf (homo sapiens) (kit ligand (homo sapiens)) (aka kit ligand)
E: None ... | [D] |
<Instruct>: Given the context 'Autoantibodies to a novel nuclear Ag, Sp100, have recently been described that recognize a nuclear protein with an apparent molecular mass of 95 to 100 kDa and a dot-like distribution within cell nuclei.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [sp100]
<Options>: A: sp100 (bos taurus) (aka sp100 nuclear antigen)
B: sp100-rs (mus musculus) (aka uncharacterized loc546065)
C: nuclear antigen sp100 (mus musculus) (aka nuclear antigen sp100)
D: sp100 (homo sapiens) (aka sp100 nuclear antigen)
E: sp140 (homo sapiens) (aka sp140 nuclear body protein)
F: ... | [D] |
<Instruct>: Given the context 'By immunoscreening of a lambda gt11 cDNA expression library derived from HeLa cells with an anti-Sp100 autoimmune serum a 0.7-kb cDNA (Sp26) coding for a fragment of Sp100 was isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [sp100]
<Options>: A: crsp100 (homo sapiens) (aka mediator complex subunit 24)
B: sp100 (bos taurus) (aka sp100 nuclear antigen)
C: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
D: sp100-rs (mus musculus) (aka uncharacterized loc546065)
E: sp100 nuclear antigen (homo sapiens) (aka sp100 n... | [E] |
<Instruct>: Given the context 'Expression of this cDNA and use of the recombinant protein in ELISA revealed that the fragment carries major Sp100 autoepitopes and that anti-Sp100 autoantibodies predominantly occur in patients suffering from primary biliary cirrhosis (50/184).', select the correct biomedical concept for... | <Mentions>: [sp100]
<Options>: A: sp100-rs (mus musculus) (aka uncharacterized loc546065)
B: crsp100 (homo sapiens) (aka mediator complex subunit 24)
C: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
D: sp100 (bos taurus) (aka sp100 nuclear antigen)
E: sp100 (sus scrofa) (aka nuclear body protein sp14... | [C] |
<Instruct>: Given the context 'Expression of this cDNA and use of the recombinant protein in ELISA revealed that the fragment carries major Sp100 autoepitopes and that anti-Sp100 autoantibodies predominantly occur in patients suffering from primary biliary cirrhosis (50/184).', select the correct biomedical concept for... | <Mentions>: [sp100]
<Options>: A: sp100-rs (mus musculus) (aka uncharacterized loc546065)
B: crsp100 (homo sapiens) (aka mediator complex subunit 24)
C: sp100 (bos taurus) (aka sp100 nuclear antigen)
D: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
E: None of the above. | [E] |
<Instruct>: Given the context 'The Sp100 autoantigen expressed in vitro from this cDNA and authenticated by a capture immunoblot assay, comigrated in SDS-PAGE with the authentic HeLa autoantigen of 95 to 100 kDa and thus showed an aberrant electrophoretic mobility.', select the correct biomedical concept for each menti... | <Mentions>: [sp100]
<Options>: A: sp100 (bos taurus) (aka sp100 nuclear antigen)
B: nuclear antigen sp100 (mus musculus) (aka nuclear antigen sp100)
C: sp100-rs (mus musculus) (aka uncharacterized loc546065)
D: sp100 (homo sapiens) (aka sp100 nuclear antigen)
E: crsp100 (homo sapiens) (aka mediator complex subunit 24)
... | [D] |
<Instruct>: Given the context 'Computer based protein sequence analysis of the Sp100 autoantigen revealed regions of striking sequence similarities to the alpha 1 and alpha 2 domains of various human and non-human MHC class I Ag and to several transacting transcriptional regulatory proteins.', select the correct biomed... | <Mentions>: [sp100]
<Options>: A: sp100-rs (mus musculus) (aka uncharacterized loc546065)
B: sp100 (drosophila melanogaster) (aka jonah 44e)
C: sp140 (homo sapiens) (aka sp140 nuclear body protein)
D: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
E: nuclear antigen sp100 (mus musculus) (aka nuclear a... | [D] |
<Instruct>: Given the context 'Although cell surface receptors for the Fc region of IgA (Fc alpha R) have been implicated in a variety of immune effector mechanisms, the molecular features of Fc alpha R remain only marginally characterized.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [fc alpha r]
<Options>: A: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
B: fcamr (homo sapiens) (aka fc alpha and mu receptor)
C: fcgammariia (homo sapiens) (aka fc gamma receptor iia)
D: fcalphari (homo sapiens) (aka fc alpha receptor)
E: fcgriiia (homo sapiens) (aka fc gamma receptor iiia)
F: None of ... | [D] |
<Instruct>: Given the context 'Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).', select the correct biomedical concept for each mention usi... | <Mentions>: [fc alpha r; fc epsilon ri]
<Options>: A: fcamr (homo sapiens) (aka fc alpha and mu receptor)
B: fcgr (homo sapiens) (aka fc gamma receptor iia)
C: fcgammariib (homo sapiens) (aka fc gamma receptor iib)
D: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
E: fcar (homo sapiens) (aka fc alpha receptor)
F: fc ... | [E; G] |
<Instruct>: Given the context 'Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).', select the correct biomedical concept for each mention usi... | <Mentions>: [fc alpha r; fc epsilon ri]
<Options>: A: fcgammariic (homo sapiens) (aka fc gamma receptor iic (gene/pseudogene))
B: fcgriiia (homo sapiens) (aka fc gamma receptor iiia)
C: fc epsilon receptor ia (homo sapiens) (aka fc epsilon receptor ia)
D: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
E: fcgammariia ... | [I; C] |
<Instruct>: Given the context 'Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
B: ferrochelatase (xenopus tropicalis) (aka ferrochelatase)
C: ferrochelatase (homo sapiens) (aka ferrochelatase)
D: ferrochelatase (gallus gallus) (aka ferrochelatase)
E: ferrochelatase-like (caenorhabditis elegans... | [C] |
<Instruct>: Given the context 'The cDNA encoding human ferrochelatase', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (gallus gallus) (aka ferrochelatase)
B: ferrochelatase (homo sapiens) (aka ferrochelatase)
C: ferrochelatase (danio rerio) (aka ferrochelatase)
D: ferrochelatase (caenorhabditis elegans) (aka ferrochelatase)
E: ferrochelatase (escherichia coli str. k-12 substr. ... | [B] |
<Instruct>: Given the context '[EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ec 4.99.1.1; ferrochelatase]
<Options>: A: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
B: ferrochelatase (bos taurus) (aka ferrochelatase)
C: ferrochelatase (danio rerio) (aka ferrochelatase)
D: ferrochelatase (gallus gallus) (aka ferrochelatase)
E: eca4 (homo sapiens) (aka gamma-... | [K; K] |
<Instruct>: Given the context '[EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ec 4.99.1.1; ferrochelatase]
<Options>: A: dj994e9.2 (homo sapiens) (aka mas1 proto-oncogene like, g protein-coupled receptor)
B: ferrochelatase (gallus gallus) (aka ferrochelatase)
C: family with sequence similarity 99 member a (homo sapiens) (aka family with sequence similarity 99 member a)
D: dj994e9.6 ... | [K; K] |
<Instruct>: Given the context 'Northern blot analysis showed two mRNAs of about 2500 and 1600 bp for ferrochelatase in K562 and HepG2 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (gallus gallus) (aka ferrochelatase)
B: ferrochelatase-like (caenorhabditis elegans) (aka ferrochelatase-like)
C: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
D: ferrochelatase (homo sapiens) (aka ferrochelatase)
E: ferrochelatase (danio rerio) ... | [D] |
<Instruct>: Given the context 'As full-length cDNA for human ferrochelatase is now available, molecular lesions related to erythropoietic protoporphyria can be characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (bos taurus) (aka ferrochelatase)
B: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
C: ferrochelatase (escherichia coli str. k-12 substr. mg1655) (aka ferrochelatase)
D: ferrochelatase (homo sapiens) (aka ferrochelatase)
E: ferrochelatase (danio r... | [D] |
<Instruct>: Given the context 'Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase; bile salt-stimulated milk lipase]
<Options>: A: lipase c, hepatic type (bos taurus) (aka lipase c, hepatic type)
B: pancreatic lipase (bos taurus) (aka pancreatic lipase)
C: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone sensitive type)
D: carboxyl e... | [D; D] |
<Instruct>: Given the context 'Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase; bile salt-stimulated milk lipase]
<Options>: A: carboxyl ester lipase (bos taurus) (aka carboxyl ester lipase)
B: liver carboxylesterase (sus scrofa) (aka liver carboxylesterase)
C: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
D: pancreatic lipase (homo sa... | [F; F] |
<Instruct>: Given the context 'Three overlapping cDNA clones covering the entire primary sequence of the bile salt stimulated lipase in human milk were isolated from a human breast lambda gt10 cDNA library by screening with the rat pancreatic cholesterol esterase cDNA.', select the correct biomedical concept for each m... | <Mentions>: [pancreatic cholesterol esterase]
<Options>: A: lipase e, hormone sensitive type (sus scrofa) (aka lipase e, hormone sensitive type)
B: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
C: lipase e, hormone sensitive type (homo sapiens) (aka lipase e, hormone se... | [F] |
<Instruct>: Given the context 'Nucleotide sequencing of the cDNA showed that the human milk lipase mRNA encodes a 748-residue protein, including a 23-residue signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [milk lipase]
<Options>: A: monoglyceride lipase (gallus gallus) (aka monoglyceride lipase)
B: lipase h (gallus gallus) (aka lipase h)
C: lipase h (bos taurus) (aka lipase h)
D: pancreatic lipase (bos taurus) (aka pancreatic lipase)
E: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
F: None... | [E] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: pancreatic lipase (bos taurus) (aka pancreatic lipase)
B: lipase, gastric (mus musculus) (aka lipase, gastric)
C: carboxylesterase 1 (homo sapiens) (aka carboxylesterase 1)
D: lipase e, hormone sensitive type (homo sapiens) (... | [I; L; I] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
B: esterase d (oryctolagus cuniculus) (aka esterase d)
C: cocaine esterase (oryctolagus cuniculus) (loc127491327 (oryctolagus cuniculus)) (aka cocaine esterase)... | [A; N; A] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
B: lipase, gastric (mus musculus) (aka lipase, gastric)
C: esterase d (oryctolagus cuniculus) (aka esterase d)
D: lipase e, hormone sensitive type (rattus norve... | [A; M; A] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: carboxylesterase 1 (homo sapiens) (aka carboxylesterase 1)
B: esterase d (oryctolagus cuniculus) (aka esterase d)
C: lipase e, hormone sensitive type (rattus norvegicus) (aka lipase e, hormone sensitive type)
D: lipase, gastr... | [L; L; L] |
<Instruct>: Given the context 'This conclusion was confirmed by isolation and sequencing of the cDNA for human pancreatic cholesterol esterase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase]
<Options>: A: liver carboxylesterase (sus scrofa) (aka liver carboxylesterase)
B: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
C: lipase e, hormone sensitive type (oryctolagus cuniculus) (aka lipase e, hormone sensitive type)
D: carboxyl ester lipase pse... | [B] |
<Instruct>: Given the context 'Analysis of the sequence for the human cholesterol esterase/milk lipase revealed similarities to other serine esterases in three distinct regions of the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [cholesterol esterase; milk lipase]
<Options>: A: pancreatic lipase (bos taurus) (aka pancreatic lipase)
B: carboxyl ester lipase (gallus gallus) (aka carboxyl ester lipase)
C: carboxyl ester lipase (bos taurus) (aka carboxyl ester lipase)
D: carboxylesterase 1 (oryctolagus cuniculus) (aka carboxylesterase ... | [H; H] |
<Instruct>: Given the context 'Analysis of the sequence for the human cholesterol esterase/milk lipase revealed similarities to other serine esterases in three distinct regions of the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [cholesterol esterase; milk lipase]
<Options>: A: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
B: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
C: carboxyl ester lipase (bos taurus) (aka carboxyl ester lipase)
D: lipase e, hormone sensitive type (homo sapiens) (aka lipas... | [A; A] |
<Instruct>: Given the context 'Complete primary structure of the E1 beta subunit of human branched chain alpha-ketoacid dehydrogenase complex deduced from the nucleotide sequence and a gene analysis of patients with this disease.
', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [e1 beta subunit]
<Options>: A: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide... | [C] |
<Instruct>: Given the context 'A defect in the E1 beta subunit of the branched chain alpha-ketoacid dehydrogenase (BCKDH) complex is one cause of maple syrup urine disease (MSUD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [e1 beta subunit]
<Options>: A: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
B: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
C: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrog... | [C] |
<Instruct>: Given the context 'In an attempt to elucidate the molecular basis of MSUD, we isolated and characterized a 1.35 kbp cDNA clone encoding the entire precursor of the E1 beta subunit of BCKDH complex from a human placental cDNA library.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [e1 beta subunit]
<Options>: A: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
C: pyruvate dehydrogenase e1 subunit beta (o... | [A] |
<Instruct>: Given the context 'Nucleotide sequence analysis revealed that the isolated cDNA clone (lambda hBE1 beta-1) contained a 5'-untranslated sequence of four nucleotides, the translated sequence of 1,176 nucleotides and the 3'-untranslated sequence of 169 nucleotides.', select the correct biomedical concept for e... | <Mentions>: [hbe1 beta-1]
<Options>: A: sodium voltage-gated channel beta subunit 1 (homo sapiens) (aka sodium voltage-gated channel beta subunit 1)
B: cholinergic receptor nicotinic beta 1 subunit (homo sapiens) (aka cholinergic receptor nicotinic beta 1 subunit)
C: sodium channel epithelial 1 subunit beta (homo sapie... | [F] |
<Instruct>: Given the context 'Comparison of the amino acid sequence predicted from the nucleotide sequence of the cDNA insert of the clone with the NH2-terminal amino acid sequence of the purified mature bovine BCKDH-E1 beta subunit showed that the cDNA insert encodes for a 342-amino acid subunit with a Mr = 37,585.',... | <Mentions>: [bckdh-e1 beta subunit]
<Options>: A: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: e1betad (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
C: bckdh e1-beta (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
D: None of t... | [D] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: e1b (homo sapiens) (branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens)) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: e1b (mus musculus) (aka small nucleolar rna, h/aca box 73a)
C: pyruvate dehydrogenase e1 subunit ... | [A; M; A] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
B: e1b (mus musculus) (aka small nucleolar rna, h/aca box 73a)
C: branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens) (aka branche... | [C; L; C] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens) (aka branched chain keto acid dehydrogenase... | [D; K; D] |
<Instruct>: Given the context 'Genomic DNA from lymphoblastoid cell lines derived from normal and five MSUD patients, in whom E1 beta was not detected by immunoblot analysis, gave the same restriction maps on Southern blot analysis.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [e1 beta]
<Options>: A: e1b (mus musculus) (aka small nucleolar rna, h/aca box 73a)
B: bckdh e1-beta (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
C: e1betad (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
D: e1c (homo sapiens) (aka small nucleolar rna, h/aca box 73... | [B] |
<Instruct>: Given the context 'Genomic DNA from lymphoblastoid cell lines derived from normal and five MSUD patients, in whom E1 beta was not detected by immunoblot analysis, gave the same restriction maps on Southern blot analysis.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [e1 beta]
<Options>: A: e1b (mus musculus) (aka small nucleolar rna, h/aca box 73a)
B: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydrogenase e1 subunit beta)
C: e1c (homo sapiens) (aka small nucleolar rna, h/aca box 73b)
D: e1betad (homo sapie... | [E] |
<Instruct>: Given the context 'Sequence and expression of a human type II mesothelial keratin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type ii mesothelial keratin]
<Options>: A: krt2 (homo sapiens) (aka keratin 2)
B: krt222 (mus musculus) (aka keratin 222)
C: krt2-3 (mus musculus) (aka keratin 84)
D: krt1-2 (mus musculus) (aka keratin 32)
E: keratin 2 (mus musculus) (aka keratin 2)
F: None of the above. | [F] |
<Instruct>: Given the context 'A cloned cDNA encoding keratin K7 (55 kD) was identified by positive hybrid selection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [k7]
<Options>: A: k8 (mus musculus) (aka keratin 8)
B: k77 (mus musculus) (aka keratin 77)
C: k9 (mus musculus) (aka keratin 9)
D: k6 (mus musculus) (aka keratin 6)
E: krt7 (homo sapiens) (aka keratin 7)
F: None of the above. | [E] |
<Instruct>: Given the context 'Southern Blot analysis indicated that this sequence is represented only once in the human genome, and Northern Blot analysis demonstrated that the gene encoding K7 is expressed in abundance in cultured bronchial and mesothelial cells, but only weakly in cultured epidermal cells and not at... | <Mentions>: [k7]
<Options>: A: k7 (homo sapiens) (keratin 7 (homo sapiens)) (aka keratin 7)
B: k6 (mus musculus) (aka keratin 6)
C: k6a (mus musculus) (aka keratin 6a)
D: k77 (mus musculus) (aka keratin 77)
E: k8 (mus musculus) (aka keratin 8)
F: None of the above. | [A] |
<Instruct>: Given the context 'The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells: whereas all of the epidermal type II keratins thus far sequenced have long nonhelical termini rich in glycine and serine, this m... | <Mentions>: [mesothelial type ii keratin]
<Options>: A: keratin 2 (mus musculus) (aka keratin 2)
B: keratin, type ii cytoskeletal 2 epidermal (glycine max) (aka keratin, type ii cytoskeletal 2 epidermal)
C: krt2-1 (mus musculus) (aka keratin 1)
D: krt2 (homo sapiens) (aka keratin 2)
E: krt1-2 (mus musculus) (aka kerati... | [F] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: hel97 (homo sapiens) (aka mitochondrial rrna methyltransferase 2)
B: map97 (homo sapiens) (aka melanotransferrin)
C: cep97 (homo sapiens) (aka centrosomal protein 97)
D: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor li... | [B; B; B] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: melanotransferrin (gallus gallus) (aka melanotransferrin)
C: map97 (homo sapiens) (aka melanotransferrin)
D: ec97 (homo sapiens) (aka vps35 endosomal protein sorting facto... | [C; C; C] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: transmembrane protein 97 (xenopus tropicalis) (aka transmembrane protein 97)
B: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
C: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin)
D: melanotransferrin (bos... | [L; L; L] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: cep97 (homo sapiens) (aka centrosomal protein 97)
C: cilia and flagella associated protein 97 (homo sapiens) (aka cilia and flagella associated protein 97)
D: melanotransf... | [G; G; G] |
<Instruct>: Given the context 'To determine the structure of this tumor-associated antigen and to identify its functional domains, we have purified and cloned p97 mRNA and determined its nucleotide sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97]
<Options>: A: map97 (homo sapiens) (aka melanotransferrin)
B: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
E: p97... | [A] |
<Instruct>: Given the context 'The mRNA encodes a 738-residue precursor, which contains the previously determined N-terminal amino acid sequence of p97.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [p97]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: map97 (homo sapiens) (aka melanotransferrin)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regula... | [B] |
<Instruct>: Given the context 'After removal of a 19-residue signal peptide, the mature p97 molecule comprises extracellular domains of 342 and 352 residues and a C-terminal 25-residue stretch of predominantly uncharged and hydrophobic amino acids, which we believe acts as a membrane anchor.', select the correct biomed... | <Mentions>: [p97]
<Options>: A: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
B: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
C: map97 (homo sapiens) (aka melanotransferrin)
D: p97 (bos taurus) (aka valosin cont... | [C] |
<Instruct>: Given the context 'Protease digestion studies show that the three major antigenic determinants of p97 are present on the N-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [p97]
<Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: p97 (bos taurus) (aka valosin containing protein)
C: map97 (homo sapiens) (aka melanotransferrin)
D: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
E: p97 (homo sapiens... | [C] |
<Instruct>: Given the context 'The domains are strikingly homologous to each other (46% amino acid sequence homology) and to the corresponding domains of human serum transferrin (39% homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [transferrin]
<Options>: A: transferrin receptor (gallus gallus) (aka transferrin receptor)
B: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
C: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
D: transferrin receptor (homo sapiens) ... | [E] |
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [p97; transferrin]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: tfr1 (homo sapiens) (aka transferrin receptor)
C: transferrin receptor (gallus gallus) (aka transferrin receptor)
D: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
E:... | [F; E] |
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [p97; transferrin]
<Options>: A: map97 (homo sapiens) (aka melanotransferrin)
B: tfr1 (homo sapiens) (aka transferrin receptor)
C: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo s... | [A; J] |
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [p97; transferrin]
<Options>: A: transferrin (homo sapiens) (aka transferrin)
B: p97 (bos taurus) (aka valosin containing protein)
C: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
D: tfrc (homo sapiens) (aka transferrin rece... | [E; A] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: serotransferrin (glycine max) (aka serotransferrin)
B: lactotransferrin (sus scrofa) (aka lactotransferrin)
C: melanotransferrin (gallus gallus) (aka melanotransferrin)
D: p97 (drosophila melanogaster) (regulatory particle non-atpase ... | [N; N; F; J] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: lactoferrin (xenopus tropicalis) (aka transferrin)
B: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin)
C: ferritin light chain (homo sapiens) (aka ferritin light chain)
D: melanotransferrin (xenopus tropicalis) (aka me... | [M; M; B; R] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: otoferlin (homo sapiens) (aka otoferlin)
B: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
C: lactoferrin (xenopus tropicalis) (aka transferrin)
D: lactoferrin (xenopus laevis) (transferrin l homeolog (xenopus l... | [R; R; Q; E] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: lactotransferrin (homo sapiens) (aka lactotransferrin)
C: lactotransferrin (mus musculus) (aka lactotransferrin)
D: hemiferrin, transferrin-like protein (rattus norvegic... | [K; K; H; B] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: lactoferrin (xenopus laevis) (transferrin l homeolog (xenopus laevis)) (aka transferrin l homeolog)
B: ferritin light chain (homo sapiens) (aka ferritin light chain)
C: lactotransferrin (oryctolagus cuniculus) (aka lactotransferrin)
D... | [K; K; N; P] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [transferrin]
<Options>: A: transferrin (homo sapiens) (aka transferrin)
B: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin))
C: transferrin receptor (gallus gallus) (aka transferrin receptor)
D: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transf... | [A] |
<Instruct>: Given the context 'Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [calcineurin b]
<Options>: A: prkcbb (xenopus tropicalis) (aka protein kinase c beta)
B: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
C: can (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b)
D: cnb (homo sapiens) (aka protein phos... | [D] |
<Instruct>: Given the context 'Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [calcineurin b]
<Options>: A: prkcbb (xenopus tropicalis) (aka protein kinase c beta)
B: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
C: can (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b)
D: calnb (homo sapiens) (aka protein ph... | [E] |
<Instruct>: Given the context 'We have identified and cloned human cDNA for the Ca2+-binding subunit of calcineurin, the brain isozyme of the Ca2+/calmodulin-stimulated protein phosphatase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ca2+-binding subunit of calcineurin]
<Options>: A: calnb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta)
B: calna1 (homo sapiens) (aka protein phosphatase 3 catalytic subunit alpha)
C: caln1 (homo sapiens) (aka calneuron 1)
D: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ de... | [E] |
<Instruct>: Given the context 'The deduced sequence of the human protein differs from bovine brain calcineurin B by an additional valine at the carboxyl terminus and substitution of Met-11 and Ser-153 by cysteine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [calcineurin b]
<Options>: A: prkcbb (xenopus tropicalis) (aka protein kinase c beta)
B: protein phosphatase 3 regulatory subunit b, beta (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, beta)
C: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
D: cnb (homo... | [D] |
<Instruct>: Given the context 'As was observed with protein levels, mRNA abundance in brain is 20-60 times that found in other tissues with the exception of HeLa cells which, like brain, contain abundant calcineurin B mRNA.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [calcineurin b]
<Options>: A: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha)
B: cnb (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b)
C: calnb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta)
D: protein phosphatase 3 regulato... | [A] |
<Instruct>: Given the context 'Human liver serine dehydratase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (sus scrofa) (aka serine dehydratase)
B: serine dehydratase (bos taurus) (aka serine dehydratase)
C: serine dehydratase (xenopus tropicalis) (aka serine dehydratase)
D: serine dehydratase (homo sapiens) (aka serine dehydratase)
E: serine dehydratase s ho... | [D] |
<Instruct>: Given the context 'Rat liver serine dehydratase cDNA was used to screen a human liver cDNA library in lambda gt11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
B: serine dehydratase (bos taurus) (aka serine dehydratase)
C: serine dehydratase (sus scrofa) (aka serine dehydratase)
D: serine dehydratase (xenopus tropicalis) (aka serine dehydratase)
E:... | [F] |
<Instruct>: Given the context 'The deduced amino acid sequence, with a calculated Mr of 34,615, was similar to that of rat liver serine dehydratase except for the absence of a segment consisting of 36 amino acid residues.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (xenopus tropicalis) (aka serine dehydratase)
B: serine dehydratase like (homo sapiens) (aka serine dehydratase like)
C: serine dehydratase like (bos taurus) (aka serine dehydratase like)
D: serine dehydratase (homo sapiens) (aka serine dehydratase)
E: s... | [F] |
<Instruct>: Given the context 'In vitro transcription/translation with the cDNA resulted in the formation of a polypeptide with an Mr of approximately 35,000, which cross-reacted with the anti-rat serine dehydratase antibody.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (sus scrofa) (aka serine dehydratase)
B: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like)
C: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
D: serine dehydratase (oryctolagus cuniculus) (aka s... | [F] |
<Instruct>: Given the context 'These results suggest that the human serine dehydratase is structurally cognate with the rat enzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
B: serine dehydratase (bos taurus) (aka serine dehydratase)
C: serine dehydratase (oryctolagus cuniculus) (aka serine dehydratase)
D: serine dehydratase like (homo sapiens) (aka serine dehyd... | [E] |
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [rac1; rac2]
<Options>: A: rac (homo sapiens) (aka akt serine/threonine kinase 1)
B: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blo... | [I; B] |
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [rac1; rac2]
<Options>: A: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
B: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
D: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pse... | [I; B] |
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [rac1; rac2]
<Options>: A: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2)
B: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
D: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) ... | [E; H] |
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [rac1; rac2]
<Options>: A: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
B: p21-rac2 (homo sapiens) (aka rac family small gtpase 2)
C: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
D: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)... | [G; B] |
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac (homo sapiens) (aka akt serine/t... | [H; F] |
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [rac1; rac2]
<Options>: A: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
... | [I; F] |
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [rac1; rac2]
<Options>: A: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
D: rac family small gtpase 1 (homo sapiens) (aka rac family sma... | [D; I] |
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [rac1; rac2]
<Options>: A: rac (homo sapiens) (aka akt serine/threonine kinase 1)
B: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
D: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka ... | [F; J] |
<Instruct>: Given the context 'The rac transcripts, particularly rac2, display relative myeloid tissue selectivity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac2]
<Options>: A: rac (homo sapiens) (aka akt serine/threonine kinase 1)
B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
C: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2)
E: p21-ra... | [E] |
<Instruct>: Given the context 'Both rac1 transcripts (2.4 and 1.1 kilobases (kb] increase when HL-60 cells differentiate to neutrophil-like morphology.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [rac1]
<Options>: A: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
D: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudo... | [E] |
<Instruct>: Given the context 'rac2 mRNA (1.45 kb) increases 7-9-fold and 3-fold upon differentiation of HL-60 and U937 cells, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac2]
<Options>: A: rac (homo sapiens) (aka akt serine/threonine kinase 1)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: p21-rac2 (homo sapiens) (aka rac family small gtpase 2)
D: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
E: rac (drosophila melanogaster... | [C] |
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac (homo sapiens) (aka akt serine/t... | [G; E] |
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [rac1; rac2]
<Options>: A: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like... | [I; G] |
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [rac1; rac2]
<Options>: A: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
B: rac (homo sapiens) (aka akt serine/threonine kinase 1)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blo... | [J; A] |
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [rac1; rac2]
<Options>: A: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
D: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
E: rac... | [G; J] |
<Instruct>: Given the context 'Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [cathepsin e]
<Options>: A: cathepsin e (gallus gallus) (aka cathepsin e)
B: cathepsin c (homo sapiens) (aka cathepsin c)
C: ctse (homo sapiens) (aka cathepsin e)
D: cathepsin e (mus musculus) (aka cathepsin e)
E: cathepsin e (rattus norvegicus) (aka cathepsin e)
F: None of the above. | [C] |
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [cathepsin e; ctse]
<Options>: A: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
B: peptidase e (homo sapiens) (aka peptidase e)
C: cathepsin c (homo sapiens) (aka cathepsin c)
D: cathepsin e (gallus gallus) (aka cathepsin e)
E: ctse (homo sapiens) (aka cathepsin e)
F: ctse (gallus gallus) (aka ... | [E; E] |
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [cathepsin e; ctse]
<Options>: A: ctse (rattus norvegicus) (aka cathepsin e)
B: cathepsin e (rattus norvegicus) (aka cathepsin e)
C: ctsa (homo sapiens) (aka cathepsin a)
D: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
E: cathepsin e (mus musculus) (aka cathep... | [F; F] |
<Instruct>: Given the context 'The CTSE cDNA clones were identified using a set of complementary 18-base oligonucleotide probes specific for a 6-residue sequence surrounding the first active site of all previously characterized human aspartic proteinases.', select the correct biomedical concept for each mention using t... | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: cathepsin e (homo sapiens) (aka cathepsin e)
C: ctsh (homo sapiens) (aka cathepsin h)
D: ctse (gallus gallus) (aka cathepsin e)
E: ctse (mus musculus) (aka cathepsin e)
F: None of the above. | [B] |
<Instruct>: Given the context 'Sequence analysis of CTSE cDNA clones revealed a 1188-base pair open reading frame that exhibited 59% sequence identity with human pepsinogen A.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ctse]
<Options>: A: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
B: ctse (gallus gallus) (aka cathepsin e)
C: ctse (homo sapiens) (aka cathepsin e)
D: ctse (rattus norvegicus) (aka cathepsin e)
E: ctsa (homo sapiens) (aka cathepsin a)
F: None of the above. | [C] |
<Instruct>: Given the context 'The predicted CTSE amino acid sequence includes a 379-residue proenzyme (Mr = 40,883) and a 17-residue signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsh (homo sapiens) (aka cathepsin h)
B: ctse (rattus norvegicus) (aka cathepsin e)
C: ctsa (homo sapiens) (aka cathepsin a)
D: cathepsin e (homo sapiens) (aka cathepsin e)
E: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
F: None of the above. | [D] |
<Instruct>: Given the context 'The predicted CTSE amino acid composition was consistent with that of purified material from gastric mucosa and gastric adenocarcinoma cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ctse]
<Options>: A: ctse (rattus norvegicus) (aka cathepsin e)
B: ctse (mus musculus) (aka cathepsin e)
C: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
D: ctse (homo sapiens) (aka cathepsin e)
E: ctsl (homo sapiens) (aka cathepsin l)
F: None of the above. | [D] |
<Instruct>: Given the context 'The predicted CTSE amino acid composition was consistent with that of purified material from gastric mucosa and gastric adenocarcinoma cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ctse]
<Options>: A: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
B: ctse (mus musculus) (aka cathepsin e)
C: ctse (rattus norvegicus) (aka cathepsin e)
D: ctsl (homo sapiens) (aka cathepsin l)
E: None of the above. | [E] |
<Instruct>: Given the context 'Additional evidence for the identification of the CTSE cDNA clones was obtained by analysis of poly(A+) RNA isolated from CTSE-producing and -nonproducing gastric adenocarcinoma cell subclones.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: ctse (rattus norvegicus) (aka cathepsin e)
C: ctse (mus musculus) (aka cathepsin e)
D: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
E: ctse (homo sapiens) (aka cathepsin e)
F: None of the above. | [E] |
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