instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcm1; atp1a2]
<Options>: A: atp1a2 (rattus norvegicus) (aka atpase na+/k+ transporting subunit alpha 2)
B: atp1al2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 4)
C: bcm1 (homo sapiens) (aka cd48 molecule)
D: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
E: mbc1 (homo sapiens... | [C; I] |
<Instruct>: Given the context 'A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd2; lfa3]
<Options>: A: lfa-2 (homo sapiens) (aka cd2 molecule)
B: lfa-3 (homo sapiens) (aka cd58 molecule)
C: cd2 molecule (homo sapiens) (aka cd2 molecule)
D: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
E: cd2 molecule (bos taurus) (aka cd2 molecule)
F: it... | [C; B] |
<Instruct>: Given the context 'A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd2; lfa3]
<Options>: A: lfa1a (homo sapiens) (aka integrin subunit alpha l)
B: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
C: lfa-2 (homo sapiens) (aka cd2 molecule)
D: cd228 (homo sapiens) (aka melanotransferrin)
E: cd21 (homo sapiens) (aka complement c3d receptor 2)
F: leu-3 (homo sapiens) (aka cd4... | [I; H] |
<Instruct>: Given the context 'A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd2; lfa3]
<Options>: A: cd22 (homo sapiens) (aka cd22 molecule)
B: cd2 (homo sapiens) (aka cd2 molecule)
C: lfa-2 (homo sapiens) (aka cd2 molecule)
D: cd228 (homo sapiens) (aka melanotransferrin)
E: cd21 (homo sapiens) (aka complement c3d receptor 2)
F: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
G: ... | [B; J] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: atpi (homo sapiens) (aka atp synthase inhibitory factor subunit 1)
B: atpase na+/k+ transporting subunit alpha 1 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 1)
C: atp1a2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
D: integrin sub... | [H; J; T; B] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: cd22 molecule (homo sapiens) (aka cd22 molecule)
B: cd2 (bos taurus) (aka cd2 molecule)
C: atpiia (homo sapiens) (aka atpase phospholipid transporting 9a (putative))
D: lfa-3 (homo sapiens) (aka cd58 molecule)
E: atp6n1a (homo sapiens) (aka atpase h+ transporting v0... | [Q; D; T; K] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: atp5a1 (homo sapiens) (aka atp synthase f1 subunit alpha)
B: atp1a1 (rattus norvegicus) (aka atpase na+/k+ transporting subunit alpha 1)
C: atpa (escherichia coli str. k-12 substr. mg1655) (aka atp synthase f1 complex subunit alpha)
D: atp synthase f1 subunit alpha ... | [E; P; U; M] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: atp synthase f1 subunit alpha (homo sapiens) (aka atp synthase f1 subunit alpha)
B: atp1a1os (homo sapiens) (aka atp1a1 antisense rna 1)
C: lfa-3 (homo sapiens) (aka cd58 molecule)
D: leu-3 (homo sapiens) (aka cd4 molecule)
E: cd2 locus control region (homo sapiens)... | [T; C; U; G] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
B: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
C: atp2c1a (homo sapiens) (aka atpase secretory pathway ca2+ transporting 1)
D: atp13a3 (homo sapiens) (aka atpase 13... | [K; H; L; O] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: atp1a2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
B: atp2a1 (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 1)
C: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
D: atpa-3 (mus musculus) (aka atpase,... | [P; M; D; A] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: atpase na+/k+ transporting subunit alpha 2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: atp13a3 (homo sapiens) (aka atpase 13a3)
D: atp1al2 (homo sapiens) (aka atpase na+/k+ transporting... | [J; P; L; A] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: atp13a3 (homo sapiens) (aka atpase 13a3)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
D: bcm-1 (mus musculus) (aka cd48 antigen)
E: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation tr... | [D; B; L; I] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: bcm1 (homo sapiens) (aka cd48 molecule)
B: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
C: atpase na+/k+ transporting subunit alpha 2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
D: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent ... | [M; A; L; C] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: leu-3 (homo sapiens) (aka cd4 molecule)
B: bcm-1 (mus musculus) (aka cd48 antigen)
C: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
D: lfa-3 (homo sapiens) (aka cd58 molecule)
E: bcrm1 (homo sapiens) (aka sideroflexin 4)
F: cd2 mo... | [H; F; D] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
B: leu-3 (homo sapiens) (aka cd4 molecule)
C: bcm1 (homo sapiens) (aka cd48 molecule)
D: cd2 molecule (bos taurus) (aka cd2 molecule)
E: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
F: cd2 molecule (ho... | [C; F; I] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
B: cd2 (gallus gallus) (aka cd2 molecule)
C: cd22 (homo sapiens) (aka cd22 molecule)
D: cd2 molecule (bos taurus) (aka cd2 molecule)
E: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
F: cd2 (homo sapiens... | [N; F; I] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd22 (homo sapiens) (aka cd22 molecule)
B: bcrm1 (homo sapiens) (aka sideroflexin 4)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: itga3 (homo sapiens) (aka integrin subunit alpha 3)
E: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
F: lfa-3 (homo sapiens) (... | [K; F; O] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd2 molecule (bos taurus) (aka cd2 molecule)
B: leu-3 (homo sapiens) (aka cd4 molecule)
C: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
D: bcrm1 (homo sapiens) (aka sideroflexin 4)
E: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
F: bcm-1 (mus musculus) (aka... | [I; H; M] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: bcm1 (mus musculus) (aka cd48 antigen)
B: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
C: integrin subunit alpha 3 (homo sapiens) (aka integrin subunit alpha 3)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd228 (homo sap... | [D; I; M] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: lfa3 (homo sapiens) (aka cd58 molecule)
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
E: bcm1 (mus musculus) (aka cd48 antigen)
F: integr... | [G; B; O] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: lfa-2 (homo sapiens) (aka cd2 molecule)
C: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapie... | [K; F; P; A] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: itga3 (homo sapiens) (aka integrin subunit alpha 3)
C: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
D: leu-3 (homo sapiens) (aka cd4 molecule)
E: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka ... | [N; K; S; P] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: mbt-1 (homo sapiens) (aka l3mbtl histone methyl-lysine binding protein 3)
B: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
C: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
D: bcm-1 (mus musculus) (aka cd48 antig... | [O; M; I; D] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: bcrm1 (homo sapiens) (aka sideroflexin 4)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: leu-3 (homo sapiens) (aka cd4 molecule)
D: cd2 (gallus gallus) (aka cd2 molecule)
E: lfa1a (homo sapiens) (aka integrin subunit alpha l)
F: lfa3 (homo sapiens) (aka cd58... | [H; F; G; N] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [bcm1]
<Options>: A: bcrm1 (homo sapiens) (aka sideroflexin 4)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
D: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
E: cdcbm1 (homo sapiens) (aka tubulin beta 3 c... | [B] |
<Instruct>: Given the context 'The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [type i tnf-r]
<Options>: A: tnfr2 (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfr1 (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
D: None of the above. | [B] |
<Instruct>: Given the context 'Two proteins which specifically bind tumor necrosis factor (TNF) have recently been isolated from human urine in our laboratory.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [tumor necrosis factor; tnf]
<Options>: A: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
B: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
C: tnfc (homo sapiens) (aka lymphotoxin beta)
D: tumor necrosis factor (oryctolagus cuniculus) (aka tumor necrosis factor)
E: tnf supe... | [G; G] |
<Instruct>: Given the context 'Two proteins which specifically bind tumor necrosis factor (TNF) have recently been isolated from human urine in our laboratory.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [tumor necrosis factor; tnf]
<Options>: A: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
B: tnfb (homo sapiens) (aka lymphotoxin alpha)
C: tumor necrosis factor (oryctolagus cuniculus) (aka tumor necrosis factor)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tnfc (h... | [H; H] |
<Instruct>: Given the context 'Two proteins which specifically bind tumor necrosis factor (TNF) have recently been isolated from human urine in our laboratory.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [tumor necrosis factor; tnf]
<Options>: A: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: tnfc (homo sapiens) (aka lymphotoxin beta... | [F; F] |
<Instruct>: Given the context 'Antibodies against one of the two TNF binding proteins (TBPI) were found to have effects characteristic of TNF, including stimulating phosphorylation of specific cellular proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [tnf]
<Options>: A: tnfa (homo sapiens) (aka tumor necrosis factor)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: tnfb (homo sapiens) (aka lymphotoxin alpha)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfam... | [A] |
<Instruct>: Given the context 'Oligonucleotide probes designed on the basis of the NH2-terminal amino acid sequence of TBPI were used to clone the cDNA for the structurally related cell surface type 1 TNF-R. It is notable that although this receptor can signal the phosphorylation of cellular proteins, it appears from i... | <Mentions>: [cell surface type 1 tnf-r]
<Options>: A: dcr1-tnfr (homo sapiens) (aka tnf receptor superfamily member 10c)
B: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
C: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
E: None of ... | [C] |
<Instruct>: Given the context 'The extracellular domain of the receptor is composed of four internal cysteine-rich repeats, homologous to structures repeated four times in the extracellular domains of the nerve growth factor receptor and the B lymphocytes surface antigen CDw40.', select the correct biomedical concept f... | <Mentions>: [nerve growth factor receptor; cdw40]
<Options>: A: tp40 (homo sapiens) (aka cd7 molecule)
B: il-40 (homo sapiens) (aka chromosome 17 open reading frame 99)
C: cd40 (homo sapiens) (aka cd40 molecule)
D: interleukin 4 receptor (homo sapiens) (aka interleukin 4 receptor)
E: nerve growth factor receptor (rattu... | [F; C] |
<Instruct>: Given the context 'The extracellular domain of the receptor is composed of four internal cysteine-rich repeats, homologous to structures repeated four times in the extracellular domains of the nerve growth factor receptor and the B lymphocytes surface antigen CDw40.', select the correct biomedical concept f... | <Mentions>: [nerve growth factor receptor; cdw40]
<Options>: A: tp40 (homo sapiens) (aka cd7 molecule)
B: hcd40l (homo sapiens) (aka cd40 ligand)
C: p75tnfr (homo sapiens) (aka tnf receptor superfamily member 1b)
D: ox40 (homo sapiens) (aka tnf receptor superfamily member 4)
E: nerve growth factor receptor (bos taurus)... | [I; F] |
<Instruct>: Given the context 'The amino acid composition and size of the extracellular domain of the type I TNF-R closely resemble those of TBPI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type i tnf-r]
<Options>: A: tnf receptor superfamily member 1a (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
C: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
D: None of the above. | [A] |
<Instruct>: Given the context 'The COOH-terminal amino acid sequence of the four cysteine rich repeats within the extracellular domain of the type I TNF-R matches the COOH-terminal sequence of TBPI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [type i tnf-r]
<Options>: A: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfr1 (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
D: None of the above. | [B] |
<Instruct>: Given the context 'The COOH-terminal amino acid sequence of the four cysteine rich repeats within the extracellular domain of the type I TNF-R matches the COOH-terminal sequence of TBPI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [type i tnf-r]
<Options>: A: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
C: None of the above. | [C] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
B: trail-r2 (homo sapiens) (aka tnf receptor superfamily member 10b)
C: tbp2 (homo sapiens) (aka tata-box binding protein like 2)
D: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
... | [A; A; D] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tata-box binding protein like 2 (bos taurus) (aka tata-box binding protein like 2)
C: tbp-b (xenopus laevis) (tata-box binding protein s homeolog (xenopus laevis)) (aka tata-box binding protei... | [K; K; E] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tnfar (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tbp-b (xenopus tropicalis) (aka tata-box binding protein)
C: tbp2 (xenopus tropicalis) (aka tata-box binding protein like 2)
D: tnfr3 (homo sapiens) (aka lymphotoxin beta receptor)
E: tnf-r (h... | [I; I; A] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
B: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
C: hyaluronan mediated motility receptor (homo sapiens) (aka hyaluronan mediated motility receptor)
D: tnf (homo sapiens) (aka ... | [G; N; D] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
B: cd44 molecule (in blood group) (xenopus tropicalis) (aka cd44 molecule (in blood group))
C: tex6 (homo sapiens) (aka rna polymerase i subunit h)
D: cd44 molecule (in blood group) (homo sapiens) (aka cd... | [F; D; E] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: cd44 molecule (in blood group) (oryctolagus cuniculus) (aka cd44 molecule (in blood group))
B: cd44 antigen (mus musculus) (aka cd44 antigen)
C: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
D: tumor necrosis factor (oryctolagus cuniculus) (aka tu... | [L; E; N] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tnf]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: tnf (homo sapiens) (aka tumor necrosis factor)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member ... | [D] |
<Instruct>: Given the context 'We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [tsg-6; tnf]
<Options>: A: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
B: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
C: tsg-6 (homo sapiens) (aka tnf alpha induced protein 6)
D: tex6 (homo sapiens) (aka rna polymerase i subunit h)
E: testis expressed transcript, y-linked 6 (homo sapie... | [C; I] |
<Instruct>: Given the context 'We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [tsg-6; tnf]
<Options>: A: tex6 (homo sapiens) (aka rna polymerase i subunit h)
B: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: lymphotoxin alpha (homo sapiens) (aka lymphotox... | [F; G] |
<Instruct>: Given the context 'In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tsg-6; tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein 6)
D: tsg-6 (homo sapiens) (aka tnf alpha induced protein 6)
E: tsg-6 (bos taur... | [D; I] |
<Instruct>: Given the context 'In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tsg-6; tnf]
<Options>: A: tsg6 (homo sapiens) (aka tnf alpha induced protein 6)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
D: tex6 (homo sapiens) (aka rna polymerase i subunit h)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily ... | [A; B] |
<Instruct>: Given the context 'The sequence of full-length TSG-6 cDNA revealed one major open reading frame predicting a polypeptide of 277 amino acids, including a typical cleavable signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [tsg-6]
<Options>: A: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
B: tsg6 (homo sapiens) (aka tnf alpha induced protein 6)
C: tex6 (homo sapiens) (aka rna polymerase i subunit h)
D: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associa... | [B] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: cap-gly domain-containing linker protein 1 homolog (caenorhabditis elegans) (aka cap-gly domain-containing linker protein 1 homolog)
B: cd44 molecule (in blood group) (xenopus tropicalis) (aka cd44 molecule (in blood group))
C: cd44 molecule (in blood grou... | [I; E; K] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: cd44 molecule (in blood group) (xenopus tropicalis) (aka cd44 molecule (in blood group))
B: tnf alpha induced protein 6 (homo sapiens) (aka tnf alpha induced protein 6)
C: tex6 (homo sapiens) (aka rna polymerase i subunit h)
D: cd44 molecule (sus scrofa) (... | [B; O; J] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: hyaluronan mediated motility receptor (homo sapiens) (aka hyaluronan mediated motility receptor)
B: cd44 molecule (sus scrofa) (aka cd44 molecule)
C: cd44 antigen (mus musculus) (aka cd44 antigen)
D: lhr (homo sapiens) (cd44 molecule (in blood group) (homo... | [O; M; D] |
<Instruct>: Given the context 'The most extensive sequence homology exists between the predicted TSG-6 protein and CD44.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6; cd44]
<Options>: A: cd44 (sus scrofa) (aka cd44 molecule)
B: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
C: cd44 molecule (in blood group) (xenopus tropicalis) (aka cd44 molecule (in blood group))
D: cd44 molecule (in blood group) (oryctolagus... | [G; H] |
<Instruct>: Given the context 'The most extensive sequence homology exists between the predicted TSG-6 protein and CD44.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6; cd44]
<Options>: A: cd44 molecule (in blood group) (oryctolagus cuniculus) (aka cd44 molecule (in blood group))
B: cd44 molecule (in blood group) (homo sapiens) (aka cd44 molecule (in blood group))
C: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
D: tnf alpha induced protein 6 (homo sapiens) ... | [D; B] |
<Instruct>: Given the context 'Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39-kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [tsg-6; tnf]
<Options>: A: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein 6)
B: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: tnfc (homo sapiens) (aka lymphotoxin beta)
E: tnfsf1 (homo sapiens) (aka ly... | [F; H] |
<Instruct>: Given the context 'Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39-kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [tsg-6; tnf]
<Options>: A: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
B: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
C: tex6 (homo sapiens) (aka rna polymerase i subunit h)
D: tnfb (homo sapiens) (aka lymphotoxin alpha)
E: tsg-6 (homo sapi... | [E; I] |
<Instruct>: Given the context 'Binding of the TSG-6 protein to hyaluronate was demonstrated by coprecipitation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6]
<Options>: A: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
B: tsg-6 (homo sapiens) (aka tnf alpha induced protein 6)
C: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein 6)
D: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
E: t... | [B] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
B: il-1 (homo sapiens) (aka interleukin 1 beta)
C: tsg6 (homo sapiens) (aka tnf alpha induced protein 6)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: ifn1@ (homo sapiens) (aka interfero... | [M; B; C] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
B: ilf-1 (homo sapiens) (aka forkhead box k2)
C: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
D: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
E: tsg6... | [H; L; E] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: interleukin 1 alpha (homo sapiens) (aka interleukin 1 alpha)
B: ilf-1 (homo sapiens) (aka forkhead box k2)
C: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
D: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
E: il-1h1 (homo sa... | [K; G; L] |
<Instruct>: Given the context 'Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc2]
<Options>: A: cdc2 (homo sapiens) (dna polymerase delta 1, catalytic subunit (homo sapiens)) (aka dna polymerase delta 1, catalytic subunit)
B: cdc2 (saccharomyces cerevisiae s288c) (aka dna-directed dna polymerase delta pol3)
C: anaphase promoting complex subunit cdc23 (saccharomyces cerevisiae s288... | [D] |
<Instruct>: Given the context 'We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle.', select the correct biomedical concept for each... | <Mentions>: [ched; cholinesterase-related cell division controller]
<Options>: A: hdc homolog, cell cycle regulator (xenopus tropicalis) (aka hdc homolog, cell cycle regulator)
B: connector enhancer of kinase suppressor of ras 2-like (gallus gallus) (aka connector enhancer of kinase suppressor of ras 2-like)
C: cesd (h... | [H; H] |
<Instruct>: Given the context 'We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle.', select the correct biomedical concept for each... | <Mentions>: [ched; cholinesterase-related cell division controller]
<Options>: A: ched1 (homo sapiens) (aka ovo like zinc finger 2)
B: connector enhancer of kinase suppressor of ras 2-like (gallus gallus) (aka connector enhancer of kinase suppressor of ras 2-like)
C: ched-related (drosophila melanogaster) (aka uncharac... | [G; G] |
<Instruct>: Given the context 'We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle.', select the correct biomedical concept for each... | <Mentions>: [ched; cholinesterase-related cell division controller]
<Options>: A: ched1 (homo sapiens) (aka ovo like zinc finger 2)
B: copper homeostasis protein cutc homolog (caenorhabditis elegans) (aka copper homeostasis protein cutc homolog)
C: ched-related (drosophila melanogaster) (aka uncharacterized protein)
D:... | [I; I] |
<Instruct>: Given the context 'Library screening, RNA blot hybridization, and direct PCR amplification of cDNA reverse-transcribed from cellular mRNA revealed that CHED mRNA is expressed in multiple tissues, including bone marrow.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [ched]
<Options>: A: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
B: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog)
C: chegdd (homo sapiens) (aka oxidation resistance 1)
D: chrd (gallus gallus) (aka chordin)
E: ched (escherichia coli str... | [A] |
<Instruct>: Given the context 'The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases, displays 34-42% identically aligned amino acid residues with other cdc2-related kinases, and is considerably longer at its amino and carboxyl termini.', select the correct biomedical... | <Mentions>: [ched]
<Options>: A: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog)
B: ched1 (homo sapiens) (aka ovo like zinc finger 2)
C: chrd (gallus gallus) (aka chordin)
D: cesd (homo sapiens) (aka lipase a, lysosomal acid type)
E: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka... | [E] |
<Instruct>: Given the context 'An antisense oligodeoxynucleotide designed to interrupt CHED's expression (AS-CHED) significantly reduced the ratio between CHED mRNA and actin mRNA within 1 hr of its addition to cultures, a reduction that persisted for 4 days.', select the correct biomedical concept for each mention usi... | <Mentions>: [ched]
<Options>: A: chrd (gallus gallus) (aka chordin)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog)
D: ched1 (homo sapiens) (aka ovo like zinc finger 2)
E: choline dehydrogenase (homo... | [B] |
<Instruct>: Given the context 'AS-CHED treatment selectively inhibited megakaryocyte development in murine bone marrow cultures but did not prevent other hematopoietic pathways, as evidenced by increasing numbers of mononuclear cells.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [ched]
<Options>: A: cesd (homo sapiens) (aka lipase a, lysosomal acid type)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: choline dehydrogenase (homo sapiens) (aka choline dehydrogenase)
D: chedda (homo sapiens) (aka atrophin 1)
E: ched1 (homo sapien... | [B] |
<Instruct>: Given the context 'An oligodeoxynucleotide blocking production of the acetylcholine-hydrolyzing enzyme, butyrylcholinesterase, displayed a similar inhibition of megakaryocytopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [butyrylcholinesterase]
<Options>: A: butyrylcholinesterase (xenopus tropicalis) (aka butyrylcholinesterase)
B: butyrylcholinesterase (oryctolagus cuniculus) (aka butyrylcholinesterase)
C: butyrylcholinesterase (bos taurus) (aka butyrylcholinesterase)
D: butyrylcholinesterase (homo sapiens) (aka butyrylchol... | [D] |
<Instruct>: Given the context 'In contrast, an oligodeoxynucleotide blocking production of the human 2Hs cdc2 homolog interfered with production of the human 2Hs cdc2 homolog interfered with cellular proliferation without altering the cell-type composition of these cultures.', select the correct biomedical concept for ... | <Mentions>: [cdc2]
<Options>: A: cdc28 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase cdc28)
B: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1)
C: cdc2 (saccharomyces cerevisiae s288c) (aka dna-directed dna polymerase delta pol3)
D: cdc2 (homo sapiens) (dna polymerase delt... | [B] |
<Instruct>: Given the context 'Therefore, these findings strengthen the link between cholinergic signaling and cell division control in hematopoiesis and implicate both CHED and cholinesterases in this differentiation process.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ched]
<Options>: A: ched-related (drosophila melanogaster) (aka uncharacterized protein)
B: ched (escherichia coli str. k-12 substr. mg1655) (aka methyl-accepting chemotaxis protein tsr)
C: ched1 (homo sapiens) (aka ovo like zinc finger 2)
D: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog... | [E] |
<Instruct>: Given the context 'The transmembrane desmosomal glycoproteins have been proposed to play a role in cell adhesion; desmoglein I (DGI) is a major member of this class of desmosomal molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [desmoglein i; dgi]
<Options>: A: desmoglein 1 (bos taurus) (aka desmoglein 1)
B: desmoglein 3 (homo sapiens) (aka desmoglein 3)
C: desmoglein 4 (homo sapiens) (aka desmoglein 4)
D: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
E: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
F: ... | [F; F] |
<Instruct>: Given the context 'The transmembrane desmosomal glycoproteins have been proposed to play a role in cell adhesion; desmoglein I (DGI) is a major member of this class of desmosomal molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [desmoglein i; dgi]
<Options>: A: dgic (homo sapiens) (aka placenta associated 8)
B: desmoglein 1 (bos taurus) (aka desmoglein 1)
C: dgi (mus musculus) (aka desmoglein 1 alpha)
D: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
E: dgki (homo sapiens) (aka diacylglycerol kinase iota)
F: de... | [G; G] |
<Instruct>: Given the context 'However, evidence supporting a role for DGI in cell adhesion or in the plaque is lacking.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dgi]
<Options>: A: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
B: dgi (mus musculus) (aka desmoglein 1 alpha)
C: dgki (homo sapiens) (aka diacylglycerol kinase iota)
D: dg1 (homo sapiens) (aka desmoglein 1)
E: dgic (homo sapiens) (aka placenta associated 8)
F: None of the above. | [D] |
<Instruct>: Given the context 'In order to begin to understand DGI function we have identified human cDNA clones encoding the entire mature polypeptide of 1000 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [dgi]
<Options>: A: dgki (homo sapiens) (aka diacylglycerol kinase iota)
B: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
C: dgsi (mus musculus) (aka ess-2 splicing factor)
D: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
E: dg1 (homo sapiens) (aka desmoglein 1)
F: None of the above... | [E] |
<Instruct>: Given the context 'Our data suggest that like the bovine DGI molecule human DGI is highly related to the calcium-dependent class of cell adhesion molecules known as cadherins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [dgi]
<Options>: A: dgic (homo sapiens) (aka placenta associated 8)
B: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
C: dgki (homo sapiens) (aka diacylglycerol kinase iota)
D: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
E: dgsi (mus musculus) (aka ess-2 splicing factor)
F: None of... | [F] |
<Instruct>: Given the context 'The highest degree of similarity between human N-cadherin and human DGI, and likewise between bovine DGI and human DGI, is greatest in the most amino-terminal extracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [n-cadherin; dgi]
<Options>: A: dgsi (mus musculus) (aka ess-2 splicing factor)
B: cadherin 1 (homo sapiens) (aka cadherin 1)
C: dgsi (homo sapiens) (aka ess-2 spliceosome associated protein)
D: neural-cadherin-like (gallus gallus) (aka neural-cadherin-like)
E: cdhn (homo sapiens) (aka cadherin 2)
F: dg1 (h... | [E; F] |
<Instruct>: Given the context 'The highest degree of similarity between human N-cadherin and human DGI, and likewise between bovine DGI and human DGI, is greatest in the most amino-terminal extracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [n-cadherin; dgi]
<Options>: A: dgsi (mus musculus) (aka ess-2 splicing factor)
B: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
C: neural-cadherin-like (gallus gallus) (aka neural-cadherin-like)
D: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
E: cdh1 (homo sapiens) (... | [F; H] |
<Instruct>: Given the context 'The cytoplasmic portion of the molecule contains a cadherin-like region and, like bovine DGI, a carboxy-terminal tail that is not present in the cadherins, comprising three additional domains.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [dgi]
<Options>: A: dgic (homo sapiens) (aka placenta associated 8)
B: dgs-i (homo sapiens) (aka ess-2 spliceosome associated protein)
C: dgi (mus musculus) (aka desmoglein 1 alpha)
D: dgki (homo sapiens) (aka diacylglycerol kinase iota)
E: dgsi (mus musculus) (aka ess-2 splicing factor)
F: None of the abov... | [F] |
<Instruct>: Given the context 'One of these contains a novel repeating motif of 29 +/- 1 residues, first identified in bovine DGI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dgi]
<Options>: A: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
B: dgsi (mus musculus) (aka ess-2 splicing factor)
C: dg1 (homo sapiens) (aka desmoglein 1)
D: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
E: dgsi (homo sapiens) (aka ess-2 spliceosome associated prote... | [F] |
<Instruct>: Given the context 'Five amino acids that are identical in bovine and human DGI lie in the second of the two predicted beta-strands, and intriguingly contain putative target sites for protein kinase C.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [dgi]
<Options>: A: dg1 (homo sapiens) (aka desmoglein 1)
B: dgki (homo sapiens) (aka diacylglycerol kinase iota)
C: dgs-i (homo sapiens) (aka ess-2 spliceosome associated protein)
D: dgic (homo sapiens) (aka placenta associated 8)
E: dgi (mus musculus) (aka desmoglein 1 alpha)
F: None of the above. | [A] |
<Instruct>: Given the context 'Characterization of human loricrin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [loricrin]
<Options>: A: loricrin cornified envelope precursor protein (homo sapiens) (aka loricrin cornified envelope precursor protein)
B: loricrin (xenopus tropicalis) (aka loricrin)
C: loricrin (sus scrofa) (aka loricrin cornified envelope precursor protein)
D: loricrin (rattus norvegicus) (aka loricrin... | [A] |
<Instruct>: Given the context 'We have isolated and characterized a full-length cDNA clone encoding human loricrin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [loricrin]
<Options>: A: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
B: loricrin-like (xenopus tropicalis) (aka loricrin-like)
C: loricrin (sus scrofa) (aka loricrin cornified envelope precursor protein)
D: loricrin-like (homo sapiens) (aka loricrin-like)
E: loricrin (bos tau... | [A] |
<Instruct>: Given the context 'Curiously, this protein displays major differences from the recently described mouse loricrin (Mehrel, T., Hohl, D., Nakazawa, H., Rothnagel, J.A., Longley, M.A., Bundman, D., Cheng, C.K., Lichti, U., Bisher, M.E., Steven, A. C., Steinert, P.M., Yuspa, S.H., and Roop, D.R. (1990)', select... | <Mentions>: [loricrin]
<Options>: A: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
B: loricrin-like (xenopus tropicalis) (aka loricrin-like)
C: loricrin (xenopus tropicalis) (aka loricrin)
D: loricrin (rattus norvegicus) (aka loricrin cornified envelope precursor protein)
E: loricrin-like ... | [A] |
<Instruct>: Given the context 'Furthermore, we have isolated four peptides from purified human cell envelopes that contain recognizable loricrin sequences and which are cross-linked by the N epsilon-(gamma-glutamyl)lysine isodipeptide bond.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [loricrin]
<Options>: A: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
B: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
C: loricrin (xenopus tropicalis) (aka loricrin)
D: loricrin-like (homo sapiens) (aka loricrin-like)
E: loricrin (rattus norvegic... | [A] |
<Instruct>: Given the context 'The presence of such bonds thus affords an explanation for the extraordinary insolubility of loricrin by cross-linking to the cell envelope and can also explain the low steady-state levels of monomeric loricrin in cytoskeletal extracts of epidermis.', select the correct biomedical concept... | <Mentions>: [loricrin]
<Options>: A: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope precursor protein)
B: loricrin-like (homo sapiens) (aka loricrin-like)
C: loricrin cornified envelope precursor protein (homo sapiens) (aka loricrin cornified envelope precursor protein)
D: loricrin (rattus norvegicus... | [C] |
<Instruct>: Given the context 'We propose a model for the structure of loricrin in which (i) the unusual glycine-serine-rich sequences adopt a flexible loop conformation, indexed on the recurrent aliphatic residues; (ii) inter- or intramolecular isodipeptide and disulfide cross-links induce or stabilize folding of lori... | <Mentions>: [loricrin]
<Options>: A: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
B: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
C: loricrin-like (xenopus tropicalis) (aka loricrin-like)
D: loricrin (sus scrofa) (aka loricrin cornified envelope precursor pr... | [A] |
<Instruct>: Given the context 'Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cocaine- and antidepressant-sensitive human noradrenaline transporter]
<Options>: A: net1 (homo sapiens) (solute carrier family 6 member 5 (homo sapiens)) (aka solute carrier family 6 member 5)
B: slc6a3 (homo sapiens) (aka solute carrier family 6 member 3)
C: nact (homo sapiens) (solute carrier family 13 ... | [D] |
<Instruct>: Given the context 'We have isolated a complementary DNA clone encoding a human noradrenaline transporter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [noradrenaline transporter]
<Options>: A: net (homo sapiens) (solute carrier family 6 member 2 (homo sapiens)) (aka solute carrier family 6 member 2)
B: solute carrier family 11 member 2 (rattus norvegicus) (aka solute carrier family 11 member 2)
C: slc6a2 (rattus norvegicus) (aka solute carrier family 6 me... | [A] |
<Instruct>: Given the context 'A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [ypt1; sec4]
<Options>: A: rab family gtpase ypt1 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt1)
B: exocyst complex component 4 (homo sapiens) (aka exocyst complex component 4)
C: ypt6 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt6)
D: sec4 (saccharomyces cerevisiae s288c) (aka ... | [A; D] |
<Instruct>: Given the context 'A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [ypt1; sec4]
<Options>: A: rab family gtpase sec4 (saccharomyces cerevisiae s288c) (aka rab family gtpase sec4)
B: sec24 (saccharomyces cerevisiae s288c) (aka copii subunit sec24)
C: sec6 (saccharomyces cerevisiae s288c) (aka snare-binding exocyst subunit sec6)
D: sec4l (homo sapiens) (aka rab40b, member ra... | [H; A] |
<Instruct>: Given the context 'One, the MDCK homolog of rab2, is associated with a structure having the characteristics of an intermediate compartment between the endoplasmic reticulum and the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [rab2]
<Options>: A: rab2 (homo sapiens) (aka rab2a, member ras oncogene family)
B: rab2 (drosophila melanogaster) (aka rab2)
C: rab, member of ras oncogene family like 2a (homo sapiens) (aka rab, member of ras oncogene family like 2a)
D: rab2b, member ras oncogene family (homo sapiens) (aka rab2b, member r... | [A] |
<Instruct>: Given the context 'The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [rab5; rab7]
<Options>: A: rab7 (homo sapiens) (rab7a, member ras oncogene family (homo sapiens)) (aka rab7a, member ras oncogene family)
B: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka rab7a, member ras oncogene family l homeolog)
C: rab7b, member ras oncogene ... | [D; A] |
<Instruct>: Given the context 'The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [rab5; rab7]
<Options>: A: rab (drosophila melanogaster) (rab5 (drosophila melanogaster)) (aka rab5)
B: rab5l (homo sapiens) (aka rab5c, member ras oncogene family)
C: rab5c, member ras oncogene family (rattus norvegicus) (aka rab5c, member ras oncogene family)
D: rab-7 (drosophila melanogaster) (aka rab7)
... | [F; I] |
<Instruct>: Given the context 'These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ypt1; sec4]
<Options>: A: exocyst complex component 4 (homo sapiens) (aka exocyst complex component 4)
B: ypt1 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt1)
C: ypt10 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt10)
D: ypt11 (saccharomyces cerevisiae s288c) (aka rab family gtpa... | [B; F] |
<Instruct>: Given the context 'These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ypt1; sec4]
<Options>: A: ypt11 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt11)
B: sec6 (saccharomyces cerevisiae s288c) (aka snare-binding exocyst subunit sec6)
C: exocyst complex component 4 (homo sapiens) (aka exocyst complex component 4)
D: ypt7 (saccharomyces cerevisiae s288c) (aka rab ... | [E; J] |
<Instruct>: Given the context 'These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ypt1; sec4]
<Options>: A: exocyst complex component 4 (homo sapiens) (aka exocyst complex component 4)
B: tpt1 (xenopus laevis) (translationally-controlled tumor protein homolog (xenopus laevis)) (aka translationally-controlled tumor protein homolog)
C: ypt11 (saccharomyces cerevisiae s288c) (aka rab famil... | [I; J] |
<Instruct>: Given the context 'A human homologue of the yeast HDEL receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdel receptor]
<Options>: A: kdelr2 (danio rerio) (aka kdel endoplasmic reticulum protein retention receptor 2a)
B: kdelr1 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 1)
C: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
D: kdelr2l (danio re... | [F] |
<Instruct>: Given the context 'There is evidence that the ERD2 gene encodes the sorting receptor that recognizes HDEL in yeast; its product is an integral membrane protein of relative molecular mass 26,000 (26K) that is not glycosylated.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [erd2]
<Options>: A: erd2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 1)
B: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
C: erdj2 (homo sapiens) (aka sec63 protein translocation regulator)
D: erd2l3 (homo sapiens) (aka kdel endoplasmic ret... | [F] |
<Instruct>: Given the context 'In contrast, Vaux et al. suggest that the mammalian KDEL receptor is a 72K glycoprotein that they detected using an anti-idiotypic antibody approach.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [kdel receptor]
<Options>: A: kdelr (xenopus tropicalis) (aka kdel endoplasmic reticulum protein retention receptor 3)
B: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
C: kdel (lys-asp-glu-leu) endoplasmic reticulum protein retention receptor 1 (mus musculus) (aka kdel ... | [D] |
<Instruct>: Given the context 'We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [erd2; kdel receptor]
<Options>: A: kdelr3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
B: dre2 (homo sapiens) (aka cytokine induced apoptosis inhibitor 1)
C: er lumen protein-retaining receptor erd-2.2 (caenorhabditis elegans) (aka er lumen protein-retaining receptor erd-2.2... | [H; H] |
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