instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'This mutation predicts the creation of a stop codon in exon 4 and therefore the truncation of the alpha1(XVIII) collagen short form, which was expressed in human adult retina.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1(xviii) collagen]
<Options>: A: collagen type xviii alpha 1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
B: collagen, type xxviii, alpha 1 (xenopus tropicalis) (aka collagen, type xxviii, alpha 1)
C: collagen type xviii alpha 1 chain (sus scrofa) (aka collagen type xviii alpha 1 chain)
D: collagen alpha-1(xxviii) chain (xenopus tropicalis) (aka collagen alpha-1(xxviii) chain)
E: None of the above. | [E] |
<Instruct>: Given the context 'These findings provide evidence that KS is caused by mutations in COL18A1 which, therefore, has a major role in determining the retinal structure as well as in the closure of the neural tube.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [col18a1]
<Options>: A: col18a1 (xenopus tropicalis) (aka collagen type xviii alpha 1)
B: col18a1 (rattus norvegicus) (aka collagen type xviii alpha 1 chain)
C: col18a1 (mus musculus) (aka collagen, type xviii, alpha 1)
D: col18a1 (danio rerio) (aka collagen type xviii alpha 1 chain a)
E: col18a1 (homo sapiens) (aka collagen type xviii alpha 1 chain)
F: None of the above. | [E] |
<Instruct>: Given the context 'CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
B: ciks (homo sapiens) (aka traf3 interacting protein 2)
C: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
D: csk (homo sapiens) (aka c-terminal src kinase)
E: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nemep (homo sapiens) (aka small integral membrane protein 43)
B: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
C: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
D: nemo like kinase (mus musculus) (aka nemo like kinase)
E: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
F: nemp1 (homo sapiens) (aka nuclear envelope integral membrane protein 1)
G: ikk-2 (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
H: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
I: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
J: ikk-beta (xenopus tropicalis) (aka inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta)
K: ikk-beta (mus musculus) (aka inhibitor of kappab kinase beta)
L: ikk1 (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
M: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
N: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
O: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
P: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
Q: nemep (mus musculus) (aka small integral membrane protein 43)
R: None of the above. | [L; G; C; C] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
B: ikkbeta (mus musculus) (aka inhibitor of kappab kinase beta)
C: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
D: ikk-beta (xenopus tropicalis) (aka inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta)
E: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
F: nemo/nlk (drosophila melanogaster) (aka nemo)
G: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
H: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
I: nemep (homo sapiens) (aka small integral membrane protein 43)
J: nemep (mus musculus) (aka small integral membrane protein 43)
K: nemo like kinase (mus musculus) (aka nemo like kinase)
L: immunoglobulin kappa deleting element or like (homo sapiens) (aka immunoglobulin kappa deleting element or like)
M: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
N: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
O: ikk1 (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
P: None of the above. | [O; H; N; N] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
B: nemo/nlk (drosophila melanogaster) (aka nemo)
C: immunoglobulin kappa deleting element or like (homo sapiens) (aka immunoglobulin kappa deleting element or like)
D: ikkbeta (mus musculus) (aka inhibitor of kappab kinase beta)
E: ikk1 (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
F: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
G: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
H: nemo like kinase (mus musculus) (aka nemo like kinase)
I: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
J: ikk-beta (xenopus tropicalis) (aka inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta)
K: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
L: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
M: nemep (homo sapiens) (aka small integral membrane protein 43)
N: nemep (mus musculus) (aka small integral membrane protein 43)
O: None of the above. | [E; L; O; O] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
B: ikkbeta (mus musculus) (aka inhibitor of kappab kinase beta)
C: nemep (homo sapiens) (aka small integral membrane protein 43)
D: ikk-beta (xenopus tropicalis) (aka inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta)
E: nemo like kinase (mus musculus) (aka nemo like kinase)
F: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
G: immunoglobulin kappa deleting element or like (homo sapiens) (aka immunoglobulin kappa deleting element or like)
H: ikk-2 (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
I: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
J: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
K: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
L: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
M: ikk-1 (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
N: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
O: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
P: nemo/nlk (drosophila melanogaster) (aka nemo)
Q: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
R: None of the above. | [M; H; Q; Q] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
B: nope (mus musculus) (aka immunoglobulin superfamily, dcc subclass, member 4)
C: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
D: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
E: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
F: ikkbeta (mus musculus) (aka inhibitor of kappab kinase beta)
G: nemp1 (homo sapiens) (aka nuclear envelope integral membrane protein 1)
H: ikk-beta (xenopus tropicalis) (aka inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase beta)
I: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
J: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
K: ntemnd (homo sapiens) (aka patatin like domain 6, lysophospholipase)
L: ikk1 (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
M: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
N: nemo (drosophila melanogaster) (aka nemo)
O: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
P: nfkbikb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
Q: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
R: None of the above. | [L; P; D; D] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ikkgamma]
<Options>: A: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
B: ikkgamma (drosophila melanogaster) (aka kenny)
C: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: ikki (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
E: ikkg (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
F: None of the above. | [E] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: ikkgammabeta (drosophila melanogaster) (aka kenny)
B: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
C: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
D: ciks (mus musculus) (aka traf3 interacting protein 2)
E: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
F: ikki (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
G: csk (homo sapiens) (aka c-terminal src kinase)
H: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
I: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
J: nemo/nlk (drosophila melanogaster) (aka nemo)
K: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
L: ciks (homo sapiens) (aka traf3 interacting protein 2)
M: clk (homo sapiens) (aka cdc like kinase 1)
N: nemep (mus musculus) (aka small integral membrane protein 43)
O: None of the above. | [L; K; K] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
B: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
C: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: ikki (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
E: ikka (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
F: clk (homo sapiens) (aka cdc like kinase 1)
G: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
H: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
I: ciks (homo sapiens) (aka traf3 interacting protein 2)
J: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
K: ikkgammabeta (drosophila melanogaster) (aka kenny)
L: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
M: nemep (mus musculus) (aka small integral membrane protein 43)
N: nope (mus musculus) (aka immunoglobulin superfamily, dcc subclass, member 4)
O: None of the above. | [I; H; H] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: ciks (homo sapiens) (aka traf3 interacting protein 2)
B: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
C: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
D: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
E: nemo (mus musculus) (aka inhibitor of kappab kinase gamma)
F: clk (homo sapiens) (aka cdc like kinase 1)
G: ciks (mus musculus) (aka traf3 interacting protein 2)
H: ikkgamma (drosophila melanogaster) (aka kenny)
I: nemo like kinase (mus musculus) (aka nemo like kinase)
J: csk (homo sapiens) (aka c-terminal src kinase)
K: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
L: nope (mus musculus) (aka immunoglobulin superfamily, dcc subclass, member 4)
M: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
N: ikk-i (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
O: None of the above. | [A; M; M] |
<Instruct>: Given the context 'When ectopically expressed, CIKS stimulates IKK and SAPK/JNK kinases and it transactivates an NF-kappaB-dependent reporter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
B: ciks (mus musculus) (aka traf3 interacting protein 2)
C: cisk (homo sapiens) (aka serum/glucocorticoid regulated kinase family member 3)
D: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
E: ciks (homo sapiens) (aka traf3 interacting protein 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'CIKS may help to connect upstream signaling events to IKK and SAPK/JNK modules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: ciks (homo sapiens) (aka traf3 interacting protein 2)
B: ciks (mus musculus) (aka traf3 interacting protein 2)
C: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
E: cisk (homo sapiens) (aka serum/glucocorticoid regulated kinase family member 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'CIKS may help to connect upstream signaling events to IKK and SAPK/JNK modules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: cisk (homo sapiens) (aka serum/glucocorticoid regulated kinase family member 3)
B: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
C: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: ciks (mus musculus) (aka traf3 interacting protein 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'CIKS could coordinate the activation of two stress-induced signaling pathways, functions reminiscent of those noted for tumor necrosis factor receptor-associated factor adaptor proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
C: ciks (mus musculus) (aka traf3 interacting protein 2)
D: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: ciks (homo sapiens) (aka traf3 interacting protein 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad4 (homo sapiens) (aka smad family member 4)
D: smad4 (mus musculus) (aka smad family member 4)
E: mad4 (homo sapiens) (aka max dimerization protein 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 3 (mus musculus) (aka smad family member 3)
B: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: smad4 (homo sapiens) (aka smad family member 4)
F: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
G: madh3 (homo sapiens) (aka smad family member 3)
H: smad4 (mus musculus) (aka smad family member 4)
I: smad family member 5 (homo sapiens) (aka smad family member 5)
J: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
K: None of the above. | [G; E] |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad3 (homo sapiens) (aka smad family member 3)
E: smad4 (drosophila melanogaster) (aka medea)
F: smad3 (mus musculus) (aka smad family member 3)
G: smad4 (mus musculus) (aka smad family member 4)
H: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
I: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
J: smad family member 4 (homo sapiens) (aka smad family member 4)
K: None of the above. | [D; J] |
<Instruct>: Given the context 'We investigated the functional consequences of four missense mutations in the Smad4 amino-terminal domain found in human tumors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: smad family member 4 (homo sapiens) (aka smad family member 4)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (mus musculus) (aka smad family member 4)
E: smad4 (drosophila melanogaster) (aka medea)
F: None of the above. | [B] |
<Instruct>: Given the context 'The mutant proteins were found to have impaired abilities to bind DNA although they were fully capable of forming complexes with Smad3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3]
<Options>: A: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
B: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
C: smad3 (homo sapiens) (aka smad family member 3)
D: smad family member 3 (mus musculus) (aka smad family member 3)
E: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
F: None of the above. | [C] |
<Instruct>: Given the context 'All four Smad4 mutants showed decreased protein stability compared to wild-type Smad4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: dpc4 (homo sapiens) (aka smad family member 4)
D: smad family member 4 (mus musculus) (aka smad family member 4)
E: smad4 (drosophila melanogaster) (aka medea)
F: None of the above. | [C] |
<Instruct>: Given the context 'Two of the Smad4 mutants (G65V and P130S) were translocated to the nucleus and were capable of transactivating a Smad-dependent promoter in a ligand-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
B: smad4 (mus musculus) (aka smad family member 4)
C: madh4 (homo sapiens) (aka smad family member 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: mad4 (homo sapiens) (aka max dimerization protein 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Two of the Smad4 mutants (G65V and P130S) were translocated to the nucleus and were capable of transactivating a Smad-dependent promoter in a ligand-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad4 (mus musculus) (aka smad family member 4)
D: smad4 (drosophila melanogaster) (aka medea)
E: None of the above. | [E] |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
C: smad family member 3 (mus musculus) (aka smad family member 3)
D: smad family member 4 (mus musculus) (aka smad family member 4)
E: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
F: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
G: dpc4 (homo sapiens) (aka smad family member 4)
H: smad4 (drosophila melanogaster) (aka medea)
I: smad3 (homo sapiens) (aka smad family member 3)
J: mad4 (homo sapiens) (aka max dimerization protein 4)
K: None of the above. | [I; G] |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
B: smad family member 5 (homo sapiens) (aka smad family member 5)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad family member 3 (homo sapiens) (aka smad family member 3)
E: smad3 (mus musculus) (aka smad family member 3)
F: smad family member 4 (homo sapiens) (aka smad family member 4)
G: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
H: smad4 (drosophila melanogaster) (aka medea)
I: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
J: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
K: None of the above. | [D; F] |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4; smad3]
<Options>: A: mad3 (homo sapiens) (max dimerization protein 3 (homo sapiens)) (aka max dimerization protein 3)
B: smad family member 3 (mus musculus) (aka smad family member 3)
C: smad family member 4 (mus musculus) (aka smad family member 4)
D: dpc4 (homo sapiens) (aka smad family member 4)
E: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
F: mad4 (homo sapiens) (aka max dimerization protein 4)
G: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
H: smad4 (drosophila melanogaster) (aka medea)
I: smad family member 3 (homo sapiens) (aka smad family member 3)
J: smad family member 5 (homo sapiens) (aka smad family member 5)
K: None of the above. | [D; I] |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4; smad3]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
C: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
D: smad4 (homo sapiens) (aka smad family member 4)
E: smad family member 4 (mus musculus) (aka smad family member 4)
F: mad3 (homo sapiens) (smad family member 3 (homo sapiens)) (aka smad family member 3)
G: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
H: smad3 (mus musculus) (aka smad family member 3)
I: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
J: mad4 (homo sapiens) (aka max dimerization protein 4)
K: None of the above. | [D; F] |
<Instruct>: Given the context 'In conclusion, mutations in the amino-terminal domain of Smad4, that are found in cancer, show loss of multiple functional properties which may contribute to tumorigenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 4 (homo sapiens) (aka smad family member 4)
D: smad family member 4 (mus musculus) (aka smad family member 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; doublecortin]
<Options>: A: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
B: doublecortin (bos taurus) (aka doublecortin)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
E: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
F: doublecortin domain containing 2 (xenopus tropicalis) (aka doublecortin domain containing 2)
G: dcx (homo sapiens) (aka doublecortin)
H: doublecortin domain containing 2 (homo sapiens) (aka doublecortin domain containing 2)
I: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
J: doublecortin (sus scrofa) (aka doublecortin)
K: None of the above. | [C; G] |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; doublecortin]
<Options>: A: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: lis3 (homo sapiens) (aka tubulin alpha 1a)
F: doublecortin (bos taurus) (aka doublecortin)
G: doublecortin domain containing 2 (xenopus tropicalis) (aka doublecortin domain containing 2)
H: dcx (homo sapiens) (aka doublecortin)
I: doublecortin (mus musculus) (aka doublecortin)
J: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
K: None of the above. | [J; H] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
B: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: lisx (homo sapiens) (aka doublecortin)
F: dcx (oryctolagus cuniculus) (aka doublecortin)
G: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
H: dcx (homo sapiens) (aka doublecortin)
I: doublecortin (xenopus tropicalis) (aka doublecortin)
J: lis1a (danio rerio) (aka platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b)
K: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
L: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
M: dcx (rattus norvegicus) (aka doublecortin)
N: None of the above. | [C; H; C] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: lisch7 (homo sapiens) (aka lipolysis stimulated lipoprotein receptor)
C: dcx (rattus norvegicus) (aka doublecortin)
D: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
E: dcx (homo sapiens) (aka doublecortin)
F: dcx (oryctolagus cuniculus) (aka doublecortin)
G: lisx (homo sapiens) (aka doublecortin)
H: dcx (mus musculus) (aka doublecortin)
I: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
J: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
K: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
L: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
M: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
N: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
O: None of the above. | [I; E; I] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
E: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
F: doublecortin (homo sapiens) (aka doublecortin)
G: lis1a (danio rerio) (aka platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b)
H: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
I: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
J: doublecortin (rattus norvegicus) (aka doublecortin)
K: lis3 (homo sapiens) (aka tubulin alpha 1a)
L: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
M: None of the above. | [D; F; D] |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
E: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
F: dcx (mus musculus) (aka doublecortin)
G: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
H: doublecortin (rattus norvegicus) (aka doublecortin)
I: doublecortin (homo sapiens) (aka doublecortin)
J: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
K: None of the above. | [G; I] |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: doublecortin (rattus norvegicus) (aka doublecortin)
C: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
F: doublecortin (xenopus tropicalis) (aka doublecortin)
G: doublecortin (homo sapiens) (aka doublecortin)
H: dcx (mus musculus) (aka doublecortin)
I: lis3 (homo sapiens) (aka tubulin alpha 1a)
J: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
K: None of the above. | [E; G] |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: dcx (rattus norvegicus) (aka doublecortin)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
F: doublecortin (homo sapiens) (aka doublecortin)
G: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
H: dcx (mus musculus) (aka doublecortin)
I: dcx (oryctolagus cuniculus) (aka doublecortin)
J: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
K: None of the above. | [F; A] |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: lis1 (drosophila melanogaster) (aka lissencephaly-1)
C: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
D: dcx (mus musculus) (aka doublecortin)
E: doublecortin (homo sapiens) (aka doublecortin)
F: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
G: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
H: dcx (rattus norvegicus) (aka doublecortin)
I: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
J: doublecortin (xenopus tropicalis) (aka doublecortin)
K: None of the above. | [E; G] |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis1 (drosophila melanogaster) (aka lissencephaly-1)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: dcx (mus musculus) (aka doublecortin)
D: doublecortin (homo sapiens) (aka doublecortin)
E: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
F: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
G: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
H: dcx (rattus norvegicus) (aka doublecortin)
I: doublecortin (xenopus tropicalis) (aka doublecortin)
J: None of the above. | [D; J] |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: dcx (mus musculus) (aka doublecortin)
C: dcx (oryctolagus cuniculus) (aka doublecortin)
D: lis3 (homo sapiens) (aka tubulin alpha 1a)
E: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
F: doublecortin (xenopus tropicalis) (aka doublecortin)
G: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
H: doublecortin (homo sapiens) (aka doublecortin)
I: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
J: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
K: None of the above. | [H; A] |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: dcx (mus musculus) (aka doublecortin)
C: doublecortin (rattus norvegicus) (aka doublecortin)
D: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: doublecortin (homo sapiens) (aka doublecortin)
G: dcx (xenopus tropicalis) (aka doublecortin)
H: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
I: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
J: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
K: None of the above. | [F; H] |
<Instruct>: Given the context 'In addition, we demonstrate homodimerization of DCX in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx]
<Options>: A: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
B: doublecortin (xenopus tropicalis) (aka doublecortin)
C: doublecortin (rattus norvegicus) (aka doublecortin)
D: dcx (oryctolagus cuniculus) (aka doublecortin)
E: dcx (homo sapiens) (aka doublecortin)
F: None of the above. | [E] |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (homo sapiens) (aka doublecortin)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: dcx (oryctolagus cuniculus) (aka doublecortin)
D: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
E: dcx (mus musculus) (aka doublecortin)
F: lis3 (homo sapiens) (aka tubulin alpha 1a)
G: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
H: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
I: dcx (rattus norvegicus) (aka doublecortin)
J: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
K: None of the above. | [H; A] |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis1 (drosophila melanogaster) (aka lissencephaly-1)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: doublecortin (rattus norvegicus) (aka doublecortin)
D: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
E: doublecortin (homo sapiens) (aka doublecortin)
F: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
G: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
H: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
I: doublecortin (xenopus tropicalis) (aka doublecortin)
J: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
K: None of the above. | [F; E] |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (homo sapiens) (aka doublecortin)
B: dcx (mus musculus) (aka doublecortin)
C: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: dcx (rattus norvegicus) (aka doublecortin)
F: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
G: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
H: dcx (oryctolagus cuniculus) (aka doublecortin)
I: doublecortin (xenopus tropicalis) (aka doublecortin)
J: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
K: None of the above. | [G; A] |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: doublecortin (homo sapiens) (aka doublecortin)
E: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
F: dcx (mus musculus) (aka doublecortin)
G: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
H: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
I: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
J: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
K: None of the above. | [B; D] |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: dcx (mus musculus) (aka doublecortin)
B: doublecortin (xenopus tropicalis) (aka doublecortin)
C: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
D: dcx (oryctolagus cuniculus) (aka doublecortin)
E: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
F: lis3 (homo sapiens) (aka tubulin alpha 1a)
G: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
H: doublecortin (homo sapiens) (aka doublecortin)
I: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
J: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
K: None of the above. | [H; J] |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: dcx (mus musculus) (aka doublecortin)
D: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
E: doublecortin (xenopus tropicalis) (aka doublecortin)
F: dcx (rattus norvegicus) (aka doublecortin)
G: dcx (homo sapiens) (aka doublecortin)
H: lis1 (drosophila melanogaster) (aka lissencephaly-1)
I: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
J: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
K: None of the above. | [G; B] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: doublecortin (rattus norvegicus) (aka doublecortin)
B: dcx (oryctolagus cuniculus) (aka doublecortin)
C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
D: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
E: lis3 (homo sapiens) (aka tubulin alpha 1a)
F: dcx (homo sapiens) (aka doublecortin)
G: doublecortin (xenopus tropicalis) (aka doublecortin)
H: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
I: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
J: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
K: None of the above. | [H; F] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
C: dcx (xenopus tropicalis) (aka doublecortin)
D: dcx (homo sapiens) (aka doublecortin)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: lis3 (homo sapiens) (aka tubulin alpha 1a)
G: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
H: dcx (oryctolagus cuniculus) (aka doublecortin)
I: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
J: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
K: None of the above. | [A; D] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1]
<Options>: A: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: lis1 (drosophila melanogaster) (aka lissencephaly-1)
D: lis3 (homo sapiens) (aka tubulin alpha 1a)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: None of the above. | [B] |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: dcx (homo sapiens) (aka doublecortin)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
E: dcx (rattus norvegicus) (aka doublecortin)
F: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
G: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
H: lis1 (drosophila melanogaster) (aka lissencephaly-1)
I: dcx (mus musculus) (aka doublecortin)
J: lis3 (homo sapiens) (aka tubulin alpha 1a)
K: None of the above. | [A; B] |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: doublecortin (homo sapiens) (aka doublecortin)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
E: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
F: lis1 (drosophila melanogaster) (aka lissencephaly-1)
G: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
H: dcx (rattus norvegicus) (aka doublecortin)
I: dcx (xenopus tropicalis) (aka doublecortin)
J: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
K: None of the above. | [C; B] |
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
D: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
E: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'Immunocytochemical studies reveal a somatodendritic Kv4.2 expression pattern, with the channels concentrated mainly at dendritic spines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
D: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
E: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'The molecular mechanism that underlies the localization of Kv4.2 to this subcellular region is unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
B: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
C: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
E: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'We used the yeast two-hybrid system to identify the Kv4.2-associated proteins that are involved in channel localization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
D: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'We used the yeast two-hybrid system to identify the Kv4.2-associated proteins that are involved in channel localization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
B: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
C: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
D: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'Here we demonstrate a direct interaction between Kv4.2 and the actin-binding protein, filamin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
E: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
C: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
D: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
E: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'To examine the functional consequences of this interaction, we expressed Kv4.2 in filamin(+) and filamin(-) cells and performed immunocytochemical and electrophysiological analyses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
B: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
C: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
D: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
E: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'Our results indicate that Kv4.2 colocalizes with filamin at filopodial roots in filamin(+) cells but shows a nonspecific expression pattern in filamin(-) cells, with no localization to filopodial roots.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
D: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
E: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
F: None of the above. | [A] |
<Instruct>: Given the context 'Furthermore, the magnitude of whole-cell Kv4.2 current density is approximately 2.7-fold larger in filamin(+) cells as compared with these currents in filamin(-) cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
D: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
E: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
D: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
E: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: echos1 (xenopus laevis) (aka transmembrane serine protease 3 l homeolog)
B: dfnb11 (homo sapiens) (aka transmembrane channel like 1)
C: tmprss3 (danio rerio) (aka transmembrane serine protease 3b)
D: dfnb9 (homo sapiens) (aka otoferlin)
E: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
F: transmembrane serine protease 3 (homo sapiens) (aka transmembrane serine protease 3)
G: dfnb15 (homo sapiens) (aka gipc pdz domain containing family member 3)
H: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20)
I: tmprss3 (sus scrofa) (aka transmembrane serine protease 3)
J: tmprss3 (homo sapiens) (transmembrane serine protease 4 (homo sapiens)) (aka transmembrane serine protease 4)
K: endometriosis, susceptibility to, 1 (homo sapiens) (aka endometriosis, susceptibility to, 1)
L: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
M: dfnb7 (homo sapiens) (aka transmembrane channel like 1)
N: wee1 pseudogene 1 (homo sapiens) (aka wee1 pseudogene 1)
O: try3 (homo sapiens) (prss3 pseudogene 3 (homo sapiens)) (aka prss3 pseudogene 3)
P: dfnb18 (homo sapiens) (aka ush1 protein network component harmonin)
Q: echos1 (xenopus tropicalis) (aka transmembrane serine protease 3)
R: None of the above. | [F; F; F; F] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: dfnb18 (homo sapiens) (aka ush1 protein network component harmonin)
B: endometriosis, susceptibility to, 1 (homo sapiens) (aka endometriosis, susceptibility to, 1)
C: echos1 (xenopus laevis) (aka transmembrane serine protease 3 l homeolog)
D: try3 (homo sapiens) (prss3 pseudogene 3 (homo sapiens)) (aka prss3 pseudogene 3)
E: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20)
F: dfnb15 (homo sapiens) (aka gipc pdz domain containing family member 3)
G: echos1 (xenopus tropicalis) (aka transmembrane serine protease 3)
H: dfnb9 (homo sapiens) (aka otoferlin)
I: dfnb7 (homo sapiens) (aka transmembrane channel like 1)
J: tmprss3 (sus scrofa) (aka transmembrane serine protease 3)
K: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
L: wee1 pseudogene 1 (homo sapiens) (aka wee1 pseudogene 1)
M: tmprss3 (danio rerio) (aka transmembrane serine protease 3b)
N: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
O: dfnb11 (homo sapiens) (aka transmembrane channel like 1)
P: tmprss3 (homo sapiens) (transmembrane serine protease 4 (homo sapiens)) (aka transmembrane serine protease 4)
Q: None of the above. | [Q; Q; Q; Q] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: dfnb11 (homo sapiens) (aka transmembrane channel like 1)
B: dfnb109 (homo sapiens) (aka epithelial splicing regulatory protein 1)
C: dfnb18 (homo sapiens) (aka ush1 protein network component harmonin)
D: endometriosis, susceptibility to, 1 (homo sapiens) (aka endometriosis, susceptibility to, 1)
E: tmprss3 (homo sapiens) (transmembrane serine protease 4 (homo sapiens)) (aka transmembrane serine protease 4)
F: dfnb9 (homo sapiens) (aka otoferlin)
G: echo virus (serotypes 4, 6, 11, 19) sensitivity (homo sapiens) (aka echo virus (serotypes 4, 6, 11, 19) sensitivity)
H: tmprss3 (danio rerio) (aka transmembrane serine protease 3b)
I: transmembrane serine protease 3 (homo sapiens) (aka transmembrane serine protease 3)
J: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
K: echos1 (xenopus tropicalis) (aka transmembrane serine protease 3)
L: dfna8 (homo sapiens) (aka tectorin alpha)
M: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
N: dfnb3 (homo sapiens) (aka myosin xva)
O: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
P: tmprss2 (homo sapiens) (aka transmembrane serine protease 2)
Q: tmprss3 (xenopus tropicalis) (transmembrane serine protease 3 (xenopus tropicalis)) (aka transmembrane serine protease 3)
R: None of the above. | [I; I; I; I] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: dfnb9 (homo sapiens) (aka otoferlin)
B: dfnb7 (homo sapiens) (aka transmembrane channel like 1)
C: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
D: transmembrane serine protease 3 (homo sapiens) (aka transmembrane serine protease 3)
E: tmprss2 (homo sapiens) (aka transmembrane serine protease 2)
F: tmprss3 (danio rerio) (aka transmembrane serine protease 3b)
G: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
H: dfna8 (homo sapiens) (aka tectorin alpha)
I: dfnb15 (homo sapiens) (aka gipc pdz domain containing family member 3)
J: dfnb40 (homo sapiens) (aka deafness, autosomal recessive 40)
K: tmprss3 (sus scrofa) (aka transmembrane serine protease 3)
L: aes-1 (homo sapiens) (aka tle family member 5, transcriptional modulator)
M: wee1 pseudogene 1 (homo sapiens) (aka wee1 pseudogene 1)
N: endometriosis, susceptibility to, 1 (homo sapiens) (aka endometriosis, susceptibility to, 1)
O: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
P: tmprss3 (xenopus tropicalis) (transmembrane serine protease 3 (xenopus tropicalis)) (aka transmembrane serine protease 3)
Q: None of the above. | [D; D; D; D] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: tmprss3 (bos taurus) (aka transmembrane serine protease 3)
B: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
C: tmprss3 (homo sapiens) (transmembrane serine protease 3 (homo sapiens)) (aka transmembrane serine protease 3)
D: dfnb110 (homo sapiens) (aka cochlin)
E: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5)
F: tmprss2 (homo sapiens) (aka transmembrane serine protease 2)
G: tmprss3 (xenopus tropicalis) (transmembrane serine protease 3 (xenopus tropicalis)) (aka transmembrane serine protease 3)
H: endometriosis, susceptibility to, 1 (homo sapiens) (aka endometriosis, susceptibility to, 1)
I: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20)
J: dfnb40 (homo sapiens) (aka deafness, autosomal recessive 40)
K: dfnb11 (homo sapiens) (aka transmembrane channel like 1)
L: dfnb9 (homo sapiens) (aka otoferlin)
M: tmprss3 (sus scrofa) (aka transmembrane serine protease 3)
N: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
O: dfn6 (homo sapiens) (aka small muscle protein x-linked)
P: echos1 (xenopus tropicalis) (aka transmembrane serine protease 3)
Q: wee1 pseudogene 1 (homo sapiens) (aka wee1 pseudogene 1)
R: None of the above. | [C; C; C; C] |
<Instruct>: Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dfnb10]
<Options>: A: dfnb11 (homo sapiens) (aka transmembrane channel like 1)
B: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
C: dfnb15 (homo sapiens) (aka gipc pdz domain containing family member 3)
D: dfnb109 (homo sapiens) (aka epithelial splicing regulatory protein 1)
E: dfnb40 (homo sapiens) (aka deafness, autosomal recessive 40)
F: None of the above. | [B] |
<Instruct>: Given the context 'A mutation in a splice-acceptor site, resulting in a 4-bp insertion in the mRNA and a frameshift, was detected in childhood onset deafness (DFNB8).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dfnb8]
<Options>: A: dfnb7 (homo sapiens) (aka transmembrane channel like 1)
B: dfnb8 (homo sapiens) (aka transmembrane serine protease 3)
C: dfna8 (homo sapiens) (aka tectorin alpha)
D: dfnb9 (homo sapiens) (aka otoferlin)
E: dfnb18 (homo sapiens) (aka ush1 protein network component harmonin)
F: None of the above. | [B] |
<Instruct>: Given the context 'A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2]
<Options>: A: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
B: palb2 (homo sapiens) (aka partner and localizer of brca2)
C: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
D: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
E: fancd2 (homo sapiens) (aka fa complementation group d2)
F: None of the above. | [C] |
<Instruct>: Given the context 'Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2]
<Options>: A: palb2 (homo sapiens) (aka partner and localizer of brca2)
B: brca2 (homo sapiens) (aka brca2 dna repair associated)
C: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
D: fancd2 (homo sapiens) (aka fa complementation group d2)
E: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
F: None of the above. | [B] |
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2]
<Options>: A: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
B: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
C: fancd2 (homo sapiens) (aka fa complementation group d2)
D: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
E: fancb (homo sapiens) (aka fa complementation group b)
F: None of the above. | [A] |
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2-associated factor 35; braf35]
<Options>: A: chromosome 6 c1orf35 homolog (xenopus tropicalis) (aka chromosome 6 c1orf35 homolog)
B: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
C: braf35 (mus musculus) (aka high mobility group 20b)
D: btaf (tbp-associated factor) homolog (caenorhabditis elegans) (aka btaf (tbp-associated factor) homolog)
E: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
F: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
G: dnaaf15 (homo sapiens) (aka pih1 domain containing 2)
H: braf35 (homo sapiens) (aka high mobility group 20b)
I: saga complex associated factor 29 (xenopus tropicalis) (aka saga complex associated factor 29)
J: staf65 (homo sapiens) (aka spt7 like, staga complex subunit gamma)
K: None of the above. | [H; H] |
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2-associated factor 35; braf35]
<Options>: A: braf35 (mus musculus) (aka high mobility group 20b)
B: btaf (tbp-associated factor) homolog (caenorhabditis elegans) (aka btaf (tbp-associated factor) homolog)
C: braf25 (homo sapiens) (aka high mobility group 20b)
D: braf2 (homo sapiens) (aka braf pseudogene 1)
E: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
F: fsap35 (homo sapiens) (aka tho complex subunit 6)
G: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
H: saga complex associated factor 29 (xenopus tropicalis) (aka saga complex associated factor 29)
I: fam35ap (homo sapiens) (aka shieldin complex subunit 2 pseudogene 2)
J: staf65 (homo sapiens) (aka spt7 like, staga complex subunit gamma)
K: None of the above. | [C; C] |
<Instruct>: Given the context 'BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [braf35]
<Options>: A: braf2 (homo sapiens) (aka braf pseudogene 1)
B: braf35 (homo sapiens) (aka high mobility group 20b)
C: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
D: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
E: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
F: None of the above. | [B] |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2; braf35]
<Options>: A: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
B: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
C: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
D: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
E: braf35 (homo sapiens) (aka high mobility group 20b)
F: braf2 (homo sapiens) (aka braf pseudogene 1)
G: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
H: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
I: fancb (homo sapiens) (aka fa complementation group b)
J: braf35 (mus musculus) (aka high mobility group 20b)
K: None of the above. | [B; J] |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2; braf35]
<Options>: A: braf35 (homo sapiens) (aka high mobility group 20b)
B: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
C: fancd2 (homo sapiens) (aka fa complementation group d2)
D: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
E: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
F: fancb (homo sapiens) (aka fa complementation group b)
G: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
H: braf35 (mus musculus) (aka high mobility group 20b)
I: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
J: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
K: None of the above. | [D; H] |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [braf35; brca2]
<Options>: A: braf35 (mus musculus) (aka high mobility group 20b)
B: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
C: brca2 (homo sapiens) (aka brca2 dna repair associated)
D: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
E: braf35 (homo sapiens) (aka high mobility group 20b)
F: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
G: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
H: fancb (homo sapiens) (aka fa complementation group b)
I: fancd2 (homo sapiens) (aka fa complementation group d2)
J: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
K: None of the above. | [E; C] |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [braf35; brca2]
<Options>: A: braf2 (homo sapiens) (aka braf pseudogene 1)
B: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
C: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
D: braf25 (homo sapiens) (aka high mobility group 20b)
E: braf35 (mus musculus) (aka high mobility group 20b)
F: fancd2 (homo sapiens) (aka fa complementation group d2)
G: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
H: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
I: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
J: palb2 (homo sapiens) (aka partner and localizer of brca2)
K: None of the above. | [D; B] |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [braf35; brca2]
<Options>: A: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
B: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
C: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
D: braf2 (homo sapiens) (aka braf pseudogene 1)
E: brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens)) (aka brca2 dna repair associated)
F: fancd2 (homo sapiens) (aka fa complementation group d2)
G: braf35 (mus musculus) (aka high mobility group 20b)
H: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
I: palb2 (homo sapiens) (aka partner and localizer of brca2)
J: None of the above. | [J; E] |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2; braf35]
<Options>: A: fancb (homo sapiens) (aka fa complementation group b)
B: fancd2 (homo sapiens) (aka fa complementation group d2)
C: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
D: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
E: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
F: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
G: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
H: braf25 (homo sapiens) (aka high mobility group 20b)
I: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
J: braf2 (homo sapiens) (aka braf pseudogene 1)
K: None of the above. | [F; H] |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2; braf35]
<Options>: A: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase l homeolog)
B: fancb (homo sapiens) (aka fa complementation group b)
C: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
D: palb2 (homo sapiens) (aka partner and localizer of brca2)
E: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
F: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
G: braf2 (homo sapiens) (aka braf pseudogene 1)
H: braf35 (homo sapiens) (aka high mobility group 20b)
I: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
J: braf1 (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
K: None of the above. | [E; H] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
B: gth1 (xenopus tropicalis) (aka glutathione s-transferase alpha 1)
C: gta (xenopus tropicalis) (aka integrin subunit alpha 2b)
D: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
E: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2)
F: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
G: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
H: nkx6b (homo sapiens) (aka nk6 homeobox 2)
I: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
J: nkx6a (homo sapiens) (aka nk6 homeobox 1)
K: gtx (drosophila melanogaster) (aka syntaxin 18)
L: nkx3b (homo sapiens) (aka nk3 homeobox 2)
M: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
N: None of the above. | [H; G; G] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
B: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
C: gtx (homo sapiens) (aka nk6 homeobox 2)
D: gta (xenopus tropicalis) (aka integrin subunit alpha 2b)
E: nkx3b (homo sapiens) (aka nk3 homeobox 2)
F: thex (xenopus laevis) (hematopoietically expressed homeobox s homeolog (xenopus laevis)) (aka hematopoietically expressed homeobox s homeolog)
G: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
H: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
I: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
J: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
K: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
L: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
M: None of the above. | [I; J; J] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: gta (xenopus tropicalis) (aka integrin subunit alpha 2b)
B: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
C: nkx3b (homo sapiens) (aka nk3 homeobox 2)
D: thex (xenopus laevis) (hematopoietically expressed homeobox s homeolog (xenopus laevis)) (aka hematopoietically expressed homeobox s homeolog)
E: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
F: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
G: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
H: gtx (homo sapiens) (aka nk6 homeobox 2)
I: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
J: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
K: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
L: None of the above. | [L; K; K] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
B: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
C: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx6.2 (xenopus tropicalis) (aka nk6 homeobox 2)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
F: thex (xenopus laevis) (hematopoietically expressed homeobox s homeolog (xenopus laevis)) (aka hematopoietically expressed homeobox s homeolog)
G: nkx3b (homo sapiens) (aka nk3 homeobox 2)
H: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
I: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
J: nkx6a (homo sapiens) (aka nk6 homeobox 1)
K: gtx (xenopus tropicalis) (aka nk6 homeobox 2)
L: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
M: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
N: gta (xenopus laevis) (aka integrin subunit alpha 2b s homeolog)
O: None of the above. | [C; B; B] |
<Instruct>: Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx3b (homo sapiens) (aka nk3 homeobox 2)
B: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
D: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2)
E: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2]
<Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
B: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
C: nkx6a (homo sapiens) (aka nk6 homeobox 1)
D: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
F: nkx3b (homo sapiens) (aka nk3 homeobox 2)
G: nkx6b (homo sapiens) (aka nk6 homeobox 2)
H: None of the above. | [G; D] |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2]
<Options>: A: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
C: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
D: nkx6a (homo sapiens) (aka nk6 homeobox 1)
E: nkx3b (homo sapiens) (aka nk3 homeobox 2)
F: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
G: nkx5-2 (homo sapiens) (aka h6 family homeobox 2)
H: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
I: nkx6b (homo sapiens) (aka nk6 homeobox 2)
J: None of the above. | [A; F] |
<Instruct>: Given the context 'Northern blot experiments showed that NKX6B expression is tightly controlled in a tissue-specific fashion with the highest site of expression being the brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx6a (homo sapiens) (aka nk6 homeobox 1)
B: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
C: nkx3b (homo sapiens) (aka nk3 homeobox 2)
D: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx6a (homo sapiens) (aka nk6 homeobox 1)
B: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
C: nkx3b (homo sapiens) (aka nk3 homeobox 2)
D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx6a (homo sapiens) (aka nk6 homeobox 1)
B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
C: nkx3b (homo sapiens) (aka nk3 homeobox 2)
D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
B: nkx6b (homo sapiens) (aka nk6 homeobox 2)
C: nkx6a (homo sapiens) (aka nk6 homeobox 1)
D: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
E: nkx3b (homo sapiens) (aka nk3 homeobox 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd58; cd2]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: cd57 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
E: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
F: cd2 (gallus gallus) (aka cd2 molecule)
G: cd2 (homo sapiens) (aka cd2 molecule)
H: cd58 molecule (homo sapiens) (aka cd58 molecule)
I: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
J: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
K: None of the above. | [H; G] |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd58; cd2]
<Options>: A: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
B: cd2 (gallus gallus) (aka cd2 molecule)
C: cd57 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
D: cd21 (homo sapiens) (aka complement c3d receptor 2)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: cd5 molecule (homo sapiens) (aka cd5 molecule)
G: cd22 molecule (homo sapiens) (aka cd22 molecule)
H: cd58 (homo sapiens) (aka cd58 molecule)
I: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
J: cd2 (homo sapiens) (aka cd2 molecule)
K: None of the above. | [H; J] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd2 molecule (bos taurus) (aka cd2 molecule)
B: cd4 (homo sapiens) (aka cd4 molecule)
C: cd58 molecule (homo sapiens) (aka cd58 molecule)
D: hm4 (homo sapiens) (aka cholinergic receptor muscarinic 4)
E: cd2 (homo sapiens) (aka cd2 molecule)
F: cd2 (gallus gallus) (aka cd2 molecule)
G: itga4 (homo sapiens) (aka integrin subunit alpha 4)
H: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
I: integrin subunit beta 4 (homo sapiens) (aka integrin subunit beta 4)
J: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
K: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
L: cd52 (homo sapiens) (aka cd52 molecule)
M: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
N: cd4 (gallus gallus) (aka cd4 molecule)
O: cd22 molecule (homo sapiens) (aka cd22 molecule)
P: None of the above. | [B; C; E] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd21 (homo sapiens) (aka complement c3d receptor 2)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
D: cd58 (homo sapiens) (aka cd58 molecule)
E: cd5 molecule (homo sapiens) (aka cd5 molecule)
F: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
G: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
H: cd2 (gallus gallus) (aka cd2 molecule)
I: cd4 (gallus gallus) (aka cd4 molecule)
J: hm4 (homo sapiens) (aka cholinergic receptor muscarinic 4)
K: cd2 (homo sapiens) (aka cd2 molecule)
L: cd22 (homo sapiens) (aka cd22 molecule)
M: cd52 molecule (homo sapiens) (aka cd52 molecule)
N: cd4 molecule (homo sapiens) (aka cd4 molecule)
O: cd4 (bos taurus) (aka cd4 molecule)
P: None of the above. | [N; D; K] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd22 molecule (homo sapiens) (aka cd22 molecule)
B: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
C: hm4 (homo sapiens) (aka cholinergic receptor muscarinic 4)
D: integrin subunit beta 4 (homo sapiens) (aka integrin subunit beta 4)
E: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
F: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
G: cd52 (homo sapiens) (aka cd52 molecule)
H: cd58 molecule (homo sapiens) (aka cd58 molecule)
I: cd2 (homo sapiens) (aka cd2 molecule)
J: cd4 molecule (homo sapiens) (aka cd4 molecule)
K: cd228 (homo sapiens) (aka melanotransferrin)
L: cd2 molecule (bos taurus) (aka cd2 molecule)
M: gp4 (homo sapiens) (aka cd36 molecule (cd36 blood group))
N: cd5 molecule (homo sapiens) (aka cd5 molecule)
O: cd2 (gallus gallus) (aka cd2 molecule)
P: None of the above. | [J; H; I] |
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