instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We have isolated cDNA clones encoding serum response factor (SRF), a ubiquitous nuclear protein that binds to the SRE.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serum response factor; srf]
<Options>: A: serum response factor (gallus gallus) (aka serum response factor)
B: serum response factor binding protein 1 (homo sapiens) (aka serum response factor binding protein 1)
C: srf (sus scrofa) (aka serum response factor)
D: srf (mus musculus) (aka serum response facto... | [E; E] |
<Instruct>: Given the context 'The SRF gene is highly conserved through evolution, and in cultured cells its transcription is itself transiently increased following serum stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [srf]
<Options>: A: serum response factor homolog b (glycine max) (aka serum response factor homolog b)
B: serum response factor (xenopus tropicalis) (aka serum response factor)
C: srf (homo sapiens) (aka serum response factor)
D: srf (mus musculus) (aka serum response factor)
E: serum response factor homol... | [C] |
<Instruct>: Given the context 'A cDNA clone of SRF expressed in vitro generates protein that forms complexes indistinguishable from those formed with HeLa cell SRF, as judged by DNA binding specificity and the ability to promote SRE-dependent in vitro transcription.', select the correct biomedical concept for each ment... | <Mentions>: [srf]
<Options>: A: serum response factor (homo sapiens) (aka serum response factor)
B: serum response factor homolog (caenorhabditis elegans) (aka serum response factor homolog)
C: serum response factor homolog b (glycine max) (aka serum response factor homolog b)
D: srf (sus scrofa) (aka serum response fa... | [A] |
<Instruct>: Given the context 'SRF binds DNA as a dimer, and the DNA binding/dimerization domain of the protein exhibits striking homology to two yeast regulatory proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [srf]
<Options>: A: serum response factor homolog b (glycine max) (aka serum response factor homolog b)
B: serum response factor (xenopus tropicalis) (aka serum response factor)
C: serum response factor (homo sapiens) (aka serum response factor)
D: srf1 (homo sapiens) (aka spermatogenesis associated 6)
E: s... | [C] |
<Instruct>: Given the context 'Isolation of cDNA clones coding for rat isovaleryl-CoA dehydrogenase and assignment of the gene to human chromosome 15.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: acyl-coa dehydrogenase very long chain (bos taurus) (aka acyl-coa dehydrogenase very long chain)
B: isovaleryl-coa dehydrogenase (oryctolagus cuniculus) (aka isovaleryl-coa dehydrogenase)
C: isovaleryl-coa dehydrogenase (xenopus tropicalis) (aka isovaleryl-coa de... | [E] |
<Instruct>: Given the context 'Rat liver mRNA encoding the cytoplasmic precursor of mitochondrial isovaleryl-CoA dehydrogenase was highly enriched by polysome immunopurification using a polyclonal monospecific antibody.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl-coa dehydrogenase (rattus norvegicus) (aka isovaleryl-coa dehydrogenase)
B: isovaleryl-coa dehydrogenase (homo sapiens) (aka isovaleryl-coa dehydrogenase)
C: isovaleryl-coa dehydrogenase (bos taurus) (aka isovaleryl-coa dehydrogenase)
D: isovaleryl-coa... | [A] |
<Instruct>: Given the context 'The purified mRNA was used to prepare a plasmid cDNA library which was screened with two oligonucleotide mixtures encoding two peptides in the amino-terminal portion of mature rat isovaleryl-CoA dehydrogenase.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl-coa dehydrogenase (rattus norvegicus) (aka isovaleryl-coa dehydrogenase)
B: isovaleryl coenzyme a dehydrogenase (mus musculus) (aka isovaleryl coenzyme a dehydrogenase)
C: isovaleryl-coa dehydrogenase (homo sapiens) (aka isovaleryl-coa dehydrogenase)
D... | [A] |
<Instruct>: Given the context 'Southern blot analysis of DNAs from human-rodent somatic cell hybrids with an isolated rat cDNA (2 kbp) assigned the isovaleryl-CoA dehydrogenase gene to the long arm of chromosome 15, region q14----qter.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl-coa dehydrogenase (danio rerio) (aka isovaleryl-coa dehydrogenase)
B: isovaleryl coenzyme a dehydrogenase (mus musculus) (aka isovaleryl coenzyme a dehydrogenase)
C: isovaleryl-coa dehydrogenase (bos taurus) (aka isovaleryl-coa dehydrogenase)
D: isoval... | [E] |
<Instruct>: Given the context 'This location differs from that of the gene for medium-chain acyl-CoA dehydrogenase, a closely related enzyme, which has been previously assigned to chromosome 1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [medium-chain acyl-coa dehydrogenase]
<Options>: A: acyl-coa dehydrogenase medium chain (homo sapiens) (aka acyl-coa dehydrogenase medium chain)
B: acyl-coa dehydrogenase medium chain (sus scrofa) (aka acyl-coa dehydrogenase medium chain)
C: medium-chain specific acyl-coa dehydrogenase, mitochondrial (bos t... | [A] |
<Instruct>: Given the context 'This location differs from that of the gene for medium-chain acyl-CoA dehydrogenase, a closely related enzyme, which has been previously assigned to chromosome 1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [medium-chain acyl-coa dehydrogenase]
<Options>: A: acyl-coenzyme a dehydrogenase, long-chain (mus musculus) (aka acyl-coenzyme a dehydrogenase, long-chain)
B: medium-chain specific acyl-coa dehydrogenase, mitochondrial (bos taurus) (aka medium-chain specific acyl-coa dehydrogenase, mitochondrial)
C: acyl-c... | [E] |
<Instruct>: Given the context 'Molecular cloning of a cDNA for human delta-aminolevulinate dehydratase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [delta-aminolevulinate dehydratase]
<Options>: A: aminolevulinate dehydratase (homo sapiens) (aka aminolevulinate dehydratase)
B: aminolevulinate, delta-, dehydratase (glycine max) (aka aminolevulinate, delta-, dehydratase)
C: aminolevulinate dehydratase (sus scrofa) (aka aminolevulinate dehydratase)
D: ami... | [A] |
<Instruct>: Given the context 'A cDNA encoding human delta-aminolevulinic acid dehydratase (ALA-D; EC 4.2.1.24), the second enzyme in the heme biosynthetic pathway, was isolated from a human liver cDNA expression library.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [delta-aminolevulinic acid dehydratase; ala-d]
<Options>: A: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
B: aminolevulinate dehydratase (oryctolagus cuniculus) (aka aminolevulinate dehydratase)
C: alad.s (xenopus laevis) (aka aminolevulinate dehydratase s homeolog)
D: aminolevulinate, d... | [H; H] |
<Instruct>: Given the context 'A cDNA encoding human delta-aminolevulinic acid dehydratase (ALA-D; EC 4.2.1.24), the second enzyme in the heme biosynthetic pathway, was isolated from a human liver cDNA expression library.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [delta-aminolevulinic acid dehydratase; ala-d]
<Options>: A: aminolevulinate dehydratase (oryctolagus cuniculus) (aka aminolevulinate dehydratase)
B: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
C: alad (glycine max) (aka aminolevulinate, delta-, dehydratase)
D: aminolevulinate dehydrata... | [H; H] |
<Instruct>: Given the context 'Of the original 17 clones selected with anti-ALA-D antibody, only four expressed anti-ALA-D epitopes as assessed by rescreening with antibody preabsorbed with purified antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [ala-d]
<Options>: A: aard (homo sapiens) (aka alanine and arginine rich domain containing protein)
B: aladin (homo sapiens) (aka aladin wd repeat nucleoporin)
C: delta-ala-d (drosophila melanogaster) (aka porphobilinogen synthase)
D: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
E: alad ... | [E] |
<Instruct>: Given the context 'The aa sequence predicted from the partial nucleotide sequence was found to be essentially colinear with the sequences of four bovine ALA-D peptides, totaling 35 non-overlapping aa residues.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [ala-d]
<Options>: A: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
B: alad (homo sapiens) (aka aminolevulinate dehydratase)
C: aard (homo sapiens) (aka alanine and arginine rich domain containing protein)
D: delta-ala-d (drosophila melanogaster) (aka porphobilinogen synthase)
E: alad (gl... | [F] |
<Instruct>: Given the context '6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme deficiency: possible interaction with glucose-6-phosphate dehydrogenase deficiency.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: 6-phosphogluconolactonase (sus scrofa) (aka 6-phosphogluconolactonase)
B: g6pd (homo sapiens) (glucose-6-phosphate dehydrogenase (homo sapiens)) (aka glucose-6-phosphate dehydrogenase)
C: glucose-6-phosphate dehydrogenase (saccharo... | [I; B] |
<Instruct>: Given the context '6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme deficiency: possible interaction with glucose-6-phosphate dehydrogenase deficiency.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: 6-phosphogluconolactonase (gallus gallus) (aka 6-phosphogluconolactonase)
B: hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase (homo sapiens) (aka hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase)
C: 6-phosphoglucono... | [H; J] |
<Instruct>: Given the context 'Partial deficiency of 6-phosphogluconolactonase (EC 3.1.1.31) of the erythrocytes was discovered as an autosomal dominant disorder.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [6-phosphogluconolactonase]
<Options>: A: 6-phosphogluconolactonase (homo sapiens) (aka 6-phosphogluconolactonase)
B: 6-phosphogluconolactonase (mus musculus) (aka 6-phosphogluconolactonase)
C: 6-phosphogluconolactonase (sus scrofa) (aka 6-phosphogluconolactonase)
D: 6-phosphogluconolactonase (gallus gallus... | [A] |
<Instruct>: Given the context 'Hemolytic anemia occurred in an individual who had inherited both the gene for 6-phosphogluconolactonase deficiency and that for deficiency of a nonhemolytic variant of glucose-6-phosphate dehydrogenase (EC 1.1.1.49).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: glucose-6-phosphate dehydrogenase (homo sapiens) (aka glucose-6-phosphate dehydrogenase)
B: glucose-6-phosphate dehydrogenase (danio rerio) (aka glucose-6-phosphate dehydrogenase)
C: 6-phosphogluconolactonase (escherichia coli str.... | [J; A] |
<Instruct>: Given the context 'Hemolytic anemia occurred in an individual who had inherited both the gene for 6-phosphogluconolactonase deficiency and that for deficiency of a nonhemolytic variant of glucose-6-phosphate dehydrogenase (EC 1.1.1.49).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: 6pgd (homo sapiens) (aka phosphogluconate dehydrogenase)
B: hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase (homo sapiens) (aka hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase)
C: 6-phosphogluconolactonase (bos ta... | [H; F] |
<Instruct>: Given the context 'It is proposed that the interaction of this hereditary erythrocyte abnormality with glucose-6-phosphate dehydrogenase deficiency may explain hemolysis in some other patients who have inherited polymorphic variants of glucose-6-phosphate dehydrogenase.', select the correct biomedical conce... | <Mentions>: [glucose-6-phosphate dehydrogenase]
<Options>: A: 6pgd (homo sapiens) (aka phosphogluconate dehydrogenase)
B: udp-glucose 6-dehydrogenase (homo sapiens) (aka udp-glucose 6-dehydrogenase)
C: glucose-6-phosphate dehydrogenase (danio rerio) (aka glucose-6-phosphate dehydrogenase)
D: g6pd (homo sapiens) (glucos... | [D] |
<Instruct>: Given the context 'Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy.
Muscle phosphoglycerate mutase activity was decreased (5.7 percent of the lowest control value) in a 52-year-old man with intolerance for strenuous exercise and recurrent pigmenturia since adolescence.',... | <Mentions>: [muscle phosphoglycerate mutase]
<Options>: A: phosphoglycerate mutase family member 5 (mus musculus) (aka phosphoglycerate mutase family member 5)
B: pgam-m (homo sapiens) (aka phosphoglycerate mutase 2)
C: phosphoglycerate mutase elevated 2 (mus musculus) (aka phosphoglycerate mutase elevated 2)
D: phosph... | [B] |
<Instruct>: Given the context 'Electrophoretic, heat lability, and mercury inhibition studies showed that the small residual activity in the patient's muscle was represented by the brain (BB) isoenzyme of phosphoglycerate mutase, suggesting a genetic defect of the M subunit which predominates in normal muscle.', select... | <Mentions>: [brain (bb) isoenzyme of phosphoglycerate mutase]
<Options>: A: probable phosphoglycerate mutase gpmb-like (glycine max) (aka probable phosphoglycerate mutase gpmb-like)
B: pgam-b (homo sapiens) (phosphoglycerate mutase family member 4 (homo sapiens)) (aka phosphoglycerate mutase family member 4)
C: pgam2 (... | [D] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: apolipoprotein c3 (homo sapiens) (aka apolipoprotein c3)
B: lwr (drosophila melanogaster) (aka lesswright)
C: lws (homo sapiens) (aka rna, u4atac small nuclear)
D: basal cell adhesion molecule (lutheran blood group) (danio rerio) (aka basal... | [O; F; N] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: complement component 3 precursor pseudogene (homo sapiens) (aka complement component 3 precursor pseudogene)
B: basal cell adhesion molecule (lutheran blood group) (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
C: ... | [E; G; B] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: basal cell adhesion molecule (lutheran blood group) (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
B: immunoglobulin light chain, lambda gene cluster (bos taurus) (aka immunoglobulin light chain, lambda gene cluste... | [I; K; A] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: ly6l (bos taurus) (aka lymphocyte antigen 6 family member l)
B: complement component 3 (gallus gallus) (aka complement component 3)
C: lw (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blo... | [C; C; E; O] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lulu (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1 like 5)
B: complement component 3 (gallus gallus) (aka complement component 3)
C: lulu (xenopus laevis) (erythrocyte membrane protein band 4.1 lik... | [F; F; D; J] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lu (bos taurus) (aka basal cell adhesion molecule)
B: basal cell adhesion molecule (lutheran blood group) (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
C: apolipoprotein c3 (homo sapiens) ... | [L; L; F; B] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: apolipoprotein c3 (homo sapiens) (aka apolipoprotein c3)
B: gwl (bos taurus) (aka microtubule associated serine/threonine kinase like)
C: lu (bos taurus) (aka basal cell adhesion molecule)
D: c3 (gallus gallus) (aka... | [R; R; H; I] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lu (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
B: lw-1 (homo sapiens) (aka heat shock transcription factor family, x-linked 1)
C: ly6l (bos taurus) (aka lymphocyte antigen 6 family membe... | [P; P; D; A] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: lw (drosophila melanogaster) (aka long wing)
B: leo1 homolog, paf1/rna polymerase ii complex component l homeolog (xenopus laevis) (aka leo1 homolog, paf1/rna polymerase ii complex component l homeolog)
C: complement c3 (homo sapiens) (aka complement c3)
D: lep (homo sapiens... | [H; Q; C; G] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: lw (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
B: leo1 homolog, paf1/rna polymerase ii complex component l homeolog (xenopus laevis) (aka leo1 homolog, paf1/rna polymerase ii complex component l homeolog)
C: c3g (drosophila melanog... | [D; O; I; A] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: le (mus musculus) (aka hps4, biogenesis of lysosomal organelles complex 3 subunit 2)
B: lipase, endothelial l homeolog (xenopus laevis) (aka lipase, endothelial l homeolog)
C: lw (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
D: limb ... | [L; S; F; C] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: complement component 3 precursor pseudogene (homo sapiens) (aka complement component 3 precursor pseudogene)
B: apoer (homo sapiens) (aka ldl receptor related protein 1)
C: apo-e (homo sapiens) (aka apolipoprotein e)
D: c3 (gallus gallus) (aka complement component 3)
E: apoe... | [C; O; N; G] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: les (homo sapiens) (aka fucosyltransferase 3 (lewis blood group))
B: apoer (homo sapiens) (aka ldl receptor related protein 1)
C: lipase, endothelial l homeolog (xenopus laevis) (aka lipase, endothelial l homeolog)
D: c3b (homo sapiens) (aka complement c3)
E: lw-1 (homo sapi... | [N; A; D; T] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: h (drosophila melanogaster) (hairless (drosophila melanogaster)) (aka hairless)
B: hx (homo sapiens) (aka hemopexin)
C: lulu (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 5)
D: pepd (homo sapiens) (aka peptidase d)
E: 28h (homo sapiens) (aka high mobility gro... | [N; G; U; D] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: lu (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group))
B: lulu (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1 like 5)
C: pepd (xenopus laevis) (aka peptidase d l homeolog)
D: sei1 (homo sapiens) (aka serta domain containing 1)
E: pepe (ho... | [A; L; U; Q] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: lulu1 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 5)
B: pepd (escherichia coli str. k-12 substr. mg1655) (aka peptidase d)
C: se (homo sapiens) (aka fucosyltransferase 2 (h blood group))
D: h (drosophila melanogaster) (hairless (drosophila melanogaster)) (a... | [T; C; U; S] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: selenon (homo sapiens) (aka selenoprotein n)
B: lu1 (homo sapiens) (aka pdz domain containing 4)
C: h (drosophila melanogaster) (hairless (drosophila melanogaster)) (aka hairless)
D: igh@ (homo sapiens) (immunoglobulin heavy locus (homo sapiens)) (aka immunoglobulin heavy loc... | [O; Q; U; J] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: dmilton (drosophila melanogaster) (aka milton)
B: nf (rattus norvegicus) (aka neurofascin)
C: dystrophin, muscular dystrophy (mus musculus) (aka dystrophin, muscular dystrophy)
D: nf (homo sapiens) (aka neurofascin)
E: dystrophia myotonica-protei... | [J; J; F; F] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: neurofascin (rattus norvegicus) (aka neurofascin)
B: dm[[1]] (drosophila melanogaster) (aka lamin)
C: nf (rattus norvegicus) (aka neurofascin)
D: dmilton (drosophila melanogaster) (aka milton)
E: neurofascin (xenopus tropicalis) (aka neurofascin)... | [R; R; Q; Q] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: neurofascin (homo sapiens) (aka neurofascin)
B: nf1 (neurofibromin 1) promoter region (homo sapiens) (aka nf1 (neurofibromin 1) promoter region)
C: dmilton (drosophila melanogaster) (aka milton)
D: neurofibromin 1 (mus musculus) (aka neurofibromi... | [R; R; L; L] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: neurofibromin-like (homo sapiens) (aka neurofibromin-like)
B: neurofascin (homo sapiens) (aka neurofascin)
C: neurofascin (rattus norvegicus) (aka neurofascin)
D: neurofibromin 1 (rattus norvegicus) (aka neurofibromin 1)
E: dmilton (drosophila me... | [J; J; O; O] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: dm[[mit]] (drosophila melanogaster) (aka lamin)
B: generalized neuroaxonal dystrophy (mus musculus) (aka generalized neuroaxonal dystrophy)
C: dm (homo sapiens) (aka dm1 protein kinase)
D: dystrophia myotonica-containing wd repeat motif (mus musc... | [C; C; N; N] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [familial hypercholesterolemia; fhc]
<Options>: A: fhh (homo sapiens) (aka calcium sensing receptor)
B: fhl1 (gallus gallus) (aka four and a half lim domains 1)
C: fh3 (homo sapiens) (aka proprotein convertase subtilisin/kexin type 9)
D: fhc (homo sapiens) (ferritin heavy chain 1 (homo sapiens)) (aka ferrit... | [J; J] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [familial hypercholesterolemia; fhc]
<Options>: A: fh1 (homo sapiens) (aka filamin b)
B: low density lipoprotein receptor (gallus gallus) (aka low density lipoprotein receptor)
C: fhh (homo sapiens) (aka calcium sensing receptor)
D: fhl1 (gallus gallus) (aka four and a half lim domains 1)
E: fh (homo sapien... | [E; E] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: limb and cns expressed 1 like l homeolog (xenopus laevis) (aka limb and cns expressed 1 like l homeolog)
B: basal cell adhesion molecule (lutheran blood group) s homeolog (xenopus laevis) (aka basal cell adhesion molecule (lutheran blood group) s homeolog)
C: opn1lw... | [H; I; I] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: lw (drosophila melanogaster) (aka long wing)
B: basal cell adhesion molecule (lutheran blood group) l homeolog (xenopus laevis) (aka basal cell adhesion molecule (lutheran blood group) l homeolog)
C: leo1 homolog, paf1/rna polymerase ii complex component (xenopus tr... | [G; M; M] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: les (homo sapiens) (aka fucosyltransferase 3 (lewis blood group))
B: selectin e (bos taurus) (aka selectin e)
C: lvwm (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit epsilon)
D: basal cell adhesion molecule (lutheran blood group) (homo sapien... | [I; A; A] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: lipase, endothelial l homeolog (xenopus laevis) (aka lipase, endothelial l homeolog)
B: complement component 3 precursor pseudogene (homo sapiens) (aka complement component 3 precursor pseudogene)
C: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila mel... | [D; M; E] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: wd repeat-containing protein lwd2-like (glycine max) (aka wd repeat-containing protein lwd2-like)
B: leb (homo sapiens) (aka mucin 5ac, oligomeric mucus/gel-forming)
C: les (homo sapiens) (aka fucosyltransferase 3 (lewis blood group))
D: c3 (gallus gallus) (aka complement componen... | [C; G; F] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: lw (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
B: wd repeat-containing protein lwd2-like (glycine max) (aka wd repeat-containing protein lwd2-like)
C: lep.l (xenopus laevis) (aka leptin l homeolog)
D: apolipoprotein c3 (homo sapiens) (ak... | [K; L; A] |
<Instruct>: Given the context 'Human beta-nerve growth factor gene sequence highly homologous to that of mouse.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-nerve growth factor]
<Options>: A: nerve growth factor (homo sapiens) (aka nerve growth factor)
B: beta-ngf (rattus norvegicus) (aka nerve growth factor)
C: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic factor)
D: nerve growth factor b (beta polypeptide) (danio ... | [A] |
<Instruct>: Given the context 'Even so, beta-NGF comprises only approximately 0.1% of the protein in this small gland, which has made the study of this polypeptide difficult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [beta-ngf]
<Options>: A: ngfib (homo sapiens) (aka nuclear receptor subfamily 4 group a member 1)
B: beta-ngf (xenopus tropicalis) (aka nerve growth factor)
C: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic factor)
D: beta-ngf (homo sapiens) (aka nerve growth factor)
E... | [D] |
<Instruct>: Given the context 'The amino acid sequence of the mouse NGF beta-chain has been determined and some information has been obtained regarding the size of a mouse precursor molecule, pro-beta-NGF, but little was known about the structure and relatedness of beta-NGF from other vertebrates.', select the correct ... | <Mentions>: [ngf beta; beta-ngf]
<Options>: A: ngfb (rattus norvegicus) (aka nerve growth factor)
B: lymphotoxin beta (rattus norvegicus) (aka lymphotoxin beta)
C: brain derived neurotrophic factor (homo sapiens) (aka brain derived neurotrophic factor)
D: beta-ngf (homo sapiens) (aka nerve growth factor)
E: neurotrophi... | [I; H] |
<Instruct>: Given the context 'The amino acid sequence of the mouse NGF beta-chain has been determined and some information has been obtained regarding the size of a mouse precursor molecule, pro-beta-NGF, but little was known about the structure and relatedness of beta-NGF from other vertebrates.', select the correct ... | <Mentions>: [ngf beta; beta-ngf]
<Options>: A: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic factor)
B: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotrophin 6 beta (pseudogene))
C: beta-ngf (homo sapiens) (aka nerve growth factor)
D: neuropeptide b (rattus norvegicus... | [J; G] |
<Instruct>: Given the context 'The amino acid sequence of the mouse NGF beta-chain has been determined and some information has been obtained regarding the size of a mouse precursor molecule, pro-beta-NGF, but little was known about the structure and relatedness of beta-NGF from other vertebrates.', select the correct ... | <Mentions>: [ngf beta; beta-ngf]
<Options>: A: ngfib (homo sapiens) (aka nuclear receptor subfamily 4 group a member 1)
B: brain derived neurotrophic factor (homo sapiens) (aka brain derived neurotrophic factor)
C: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic factor)
D: ngfb (bo... | [I; I] |
<Instruct>: Given the context 'Here we describe the isolation of mouse beta-NGF complementary DNA (cDNA) and present its nucleotide sequence, which predicts a prepro-beta-NGF molecule of Mr 27,000 (27K) and a pro-beta-NGF molecule of Mr 25K. We have used the mouse beta-NGF cDNA clone to isolate the human beta-NGF gene,... | <Mentions>: [beta-ngf]
<Options>: A: ngfb (bos taurus) (aka nerve growth factor)
B: ngf (homo sapiens) (aka nerve growth factor)
C: beta-ngf (xenopus tropicalis) (aka nerve growth factor)
D: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotrophin 6 beta (pseudogene))
E: brain derived neurotrophic factor (homo... | [F] |
<Instruct>: Given the context 'Here we describe the isolation of mouse beta-NGF complementary DNA (cDNA) and present its nucleotide sequence, which predicts a prepro-beta-NGF molecule of Mr 27,000 (27K) and a pro-beta-NGF molecule of Mr 25K. We have used the mouse beta-NGF cDNA clone to isolate the human beta-NGF gene,... | <Mentions>: [beta-ngf]
<Options>: A: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic factor)
B: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotrophin 6 beta (pseudogene))
C: beta-ngf (rattus norvegicus) (aka nerve growth factor)
D: brain derived neurotrophic factor (hom... | [E] |
<Instruct>: Given the context 'Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [alpha subunit of the rod cgmp-gated channel]
<Options>: A: cyclic nucleotide gated channel subunit alpha 1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
B: protein kinase camp-dependent type i regulatory subunit alpha (homo sapiens) (aka protein kinase camp-dependent type i regulator... | [F] |
<Instruct>: Given the context 'Mutations in the genes encoding two proteins of the retinal rod phototransduction cascade, opsin and the beta subunit of rod cGMP phosphodiesterase, cause retinitis pigmentosa (RP) in some families.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [beta subunit of rod cgmp phosphodiesterase]
<Options>: A: pde1b (homo sapiens) (aka phosphodiesterase 1b)
B: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
C: pde6b (homo sapiens) (aka phosphodiesterase 6b)
D: pdeiv... | [C] |
<Instruct>: Given the context 'We screened 94 unrelated patients with autosomal dominant RP and 173 unrelated patients with autosomal recessive RP for mutations in the gene encoding the alpha subunit of the rod cGMP-gated cation channel.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [alpha subunit of the rod cgmp-gated cation channel]
<Options>: A: protein kinase camp-dependent type i regulatory subunit alpha (homo sapiens) (aka protein kinase camp-dependent type i regulatory subunit alpha)
B: rcncalpha (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
C: calcium vol... | [F] |
<Instruct>: Given the context 'Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [cellular apoptosis susceptibility gene; cse1]
<Options>: A: cse1 chromosome segregation 1-like s homeolog (xenopus laevis) (aka cse1 chromosome segregation 1-like s homeolog)
B: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
C: cse1 chromosome segregation 1-like (xenopus tropica... | [J; B] |
<Instruct>: Given the context 'Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [cellular apoptosis susceptibility gene; cse1]
<Options>: A: caspr (homo sapiens) (aka contactin associated protein 1)
B: cse (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
C: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr... | [G; I] |
<Instruct>: Given the context 'We report here that one of these fragments is an antisense fragment of a gene homologous to the essential yeast chromosome segregation gene CSE1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [cse1]
<Options>: A: csen (homo sapiens) (aka potassium voltage-gated channel interacting protein 3)
B: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr system cascade subunit casa)
C: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
D: cse1 chromosome segregat... | [C] |
<Instruct>: Given the context 'We report here that one of these fragments is an antisense fragment of a gene homologous to the essential yeast chromosome segregation gene CSE1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [cse1]
<Options>: A: csen (homo sapiens) (aka potassium voltage-gated channel interacting protein 3)
B: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr system cascade subunit casa)
C: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse1 chromosome segregation 1-like)
D: cs... | [E] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: casa (homo sapiens) (aka casein alpha s1)
B: radiation sensitivity/chromosome instability syndrome, autosomal dominant (homo sapiens) (aka radiation sensitivity/chromosome instability syndrome, autosomal dominant)
C: cancer susceptibility 11 ... | [J; I; I] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: radiation sensitivity/chromosome instability syndrome, autosomal dominant (homo sapiens) (aka radiation sensitivity/chromosome instability syndrome, autosomal dominant)
B: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
C: cancer... | [F; H; H] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr system cascade subunit casa)
B: cas1p (homo sapiens) (aka cas1 domain sialic acid o acetyltransferase 1)
C: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse... | [L; H; H] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1]
<Options>: A: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr system cascade subunit casa)
B: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
C: csen (homo sapiens) (aka potassium voltage-gated channel interacting protein 3)
D: cse (drosophila melanoga... | [B] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1]
<Options>: A: cse-c (homo sapiens) (aka sialic acid acetylesterase)
B: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr system cascade subunit casa)
C: csen (homo sapiens) (aka potassium voltage-gated channel interacting protein 3)
D: cse (drosophila melanogaster) (chromosome seg... | [E] |
<Instruct>: Given the context 'The conservation of this gene indicates it has an important function in human cells consistent with the essential role of CSE1 in yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [cse1]
<Options>: A: cse1 (homo sapiens) (aka chromosome segregation 1 like)
B: csen (homo sapiens) (aka potassium voltage-gated channel interacting protein 3)
C: cse (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
D: cse1 (saccharomyces cerevisi... | [D] |
<Instruct>: Given the context 'CAS is highly expressed in human tumor cell lines and in human testis and fetal liver, tissues that contain actively dividing cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [cas]
<Options>: A: cas1p (homo sapiens) (aka cas1 domain sialic acid o acetyltransferase 1)
B: cas (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
C: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas famil... | [E] |
<Instruct>: Given the context 'Furthermore, CAS expression increases when resting human fibroblasts are induced to proliferate and decreases when they are growth-arrested.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [cas]
<Options>: A: casr (homo sapiens) (aka calcium sensing receptor)
B: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
C: bcar1 scaffold protein, cas family member (gallus gallus) (aka bcar1 scaffold protein, cas family member)
D: cas (drosophila melanogaster) (chromosome segregation 1 (dros... | [E] |
<Instruct>: Given the context 'Thus, CAS appears to play an important role in both toxin and tumor necrosis factor-mediated cell death, as well as in cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [cas]
<Options>: A: cas1p (homo sapiens) (aka cas1 domain sialic acid o acetyltransferase 1)
B: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
C: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka chromosome segregation 1 like)
D: casa (homo sapiens) (aka casein alpha s1)
E... | [C] |
<Instruct>: Given the context 'They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines.', select the... | <Mentions>: [c-erbb-2; brca1]
<Options>: A: her-2/neu (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
B: brca1 (homo sapiens) (aka brca1 dna repair associated)
C: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
D: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b... | [A; B] |
<Instruct>: Given the context 'They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines.', select the... | <Mentions>: [c-erbb-2; brca1]
<Options>: A: erb-b2 receptor tyrosine kinase 3 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 3)
B: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type... | [F; C] |
<Instruct>: Given the context 'Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [striatum-enriched phosphatase; step]
<Options>: A: ptpe (homo sapiens) (aka protein tyrosine phosphatase receptor type e)
B: ptpstep (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
C: step1 (arabidopsis thaliana) (aka 31-kda rna binding protein)
D: ctd small phosphatase like (sus scro... | [B; B] |
<Instruct>: Given the context 'Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [striatum-enriched phosphatase; step]
<Options>: A: stepp (homo sapiens) (aka peroxisomal testis enriched protein 1)
B: step1 (arabidopsis thaliana) (aka 31-kda rna binding protein)
C: ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like (sus scrofa) (aka ectonucleotide pyrophosphatase/phos... | [I; I] |
<Instruct>: Given the context 'Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [striatum-enriched phosphatase; step]
<Options>: A: phosphoethanolamine/phosphocholine phosphatase (sus scrofa) (aka phosphoethanolamine/phosphocholine phosphatase)
B: o-sialoglycoprotein endopeptidase (sus scrofa) (aka o-sialoglycoprotein endopeptidase)
C: phosphoserine phosphatase (homo sapiens) (aka phos... | [H; H] |
<Instruct>: Given the context 'By using a combination of somatic cell hybrid analysis and fluorescence in situ hybridization, we have mapped the human STEP locus to chromosome 11p15.2-p15.1 and the murine STEP gene to chromosome 7B3-B5.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [step]
<Options>: A: step1 (arabidopsis thaliana) (aka 31-kda rna binding protein)
B: tptep (homo sapiens) (aka tpte2 pseudogene 4)
C: step (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 5)
D: step61 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
E: step (drosophi... | [D] |
<Instruct>: Given the context 'These are two regions of known conserved synteny, providing further evidence that the human STEP is a true homolog of the murine STEP gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [step]
<Options>: A: step (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 5)
B: tppp (sus scrofa) (aka tubulin polymerization promoting protein)
C: step61 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
D: stp-1 (sus scrofa) (aka transition protein 1)
E: try (sus sc... | [C] |
<Instruct>: Given the context 'Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [atp synthase oscp subunit; atp5o]
<Options>: A: atp5h (homo sapiens) (aka atp synthase peripheral stalk subunit d)
B: oscp (homo sapiens) (atp synthase peripheral stalk subunit oscp (homo sapiens)) (aka atp synthase peripheral stalk subunit oscp)
C: atp5e (homo sapiens) (aka atp synthase f1 subunit epsilon... | [B; B] |
<Instruct>: Given the context 'Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [atp synthase oscp subunit; atp5o]
<Options>: A: atp synthase peripheral stalk subunit oscp (mus musculus) (aka atp synthase peripheral stalk subunit oscp)
B: atp5o (mus musculus) (aka atp synthase peripheral stalk subunit oscp)
C: atp synthase peripheral stalk subunit oscp (oryctolagus cuniculus) (aka atp ... | [D; D] |
<Instruct>: Given the context 'We subsequently cloned the full-length human ATP synthase OSCP cDNA (GDB/HGMW approved name ATP50) from infant brain and muscle libraries and determined its nucleotide and deduced amino acid sequence (EMBL/GenBank Accession No. X83218).', select the correct biomedical concept for each men... | <Mentions>: [atp synthase oscp; atp50]
<Options>: A: oscp (homo sapiens) (atp synthase peripheral stalk subunit oscp (homo sapiens)) (aka atp synthase peripheral stalk subunit oscp)
B: atp synthase peripheral stalk subunit oscp (sus scrofa) (aka atp synthase peripheral stalk subunit oscp)
C: atp synthase peripheral sta... | [A; A] |
<Instruct>: Given the context 'We subsequently cloned the full-length human ATP synthase OSCP cDNA (GDB/HGMW approved name ATP50) from infant brain and muscle libraries and determined its nucleotide and deduced amino acid sequence (EMBL/GenBank Accession No. X83218).', select the correct biomedical concept for each men... | <Mentions>: [atp synthase oscp; atp50]
<Options>: A: atp20 (saccharomyces cerevisiae s288c) (aka f1f0 atp synthase subunit g)
B: atp10p (saccharomyces cerevisiae s288c) (aka atp10p)
C: atp synthase peripheral stalk subunit oscp (xenopus tropicalis) (aka atp synthase peripheral stalk subunit oscp)
D: atp synthase periph... | [I; I] |
<Instruct>: Given the context 'We subsequently cloned the full-length human ATP synthase OSCP cDNA (GDB/HGMW approved name ATP50) from infant brain and muscle libraries and determined its nucleotide and deduced amino acid sequence (EMBL/GenBank Accession No. X83218).', select the correct biomedical concept for each men... | <Mentions>: [atp synthase oscp; atp50]
<Options>: A: atpl (homo sapiens) (aka atpase h+ transporting v0 subunit c)
B: atp20 (saccharomyces cerevisiae s288c) (aka f1f0 atp synthase subunit g)
C: atpo (xenopus laevis) (atp synthase peripheral stalk subunit oscp s homeolog (xenopus laevis)) (aka atp synthase peripheral st... | [F; F] |
<Instruct>: Given the context 'The human ATP5O gene is located at 21q22.1-q22.2, just proximal to D21S17, in YACs 860G11 and 838C7 of the Chumakov et al.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [atp5o]
<Options>: A: atp5o (mus musculus) (aka atp synthase peripheral stalk subunit oscp)
B: atp5h (homo sapiens) (aka atp synthase peripheral stalk subunit d)
C: atp5l (homo sapiens) (aka atp synthase membrane subunit g)
D: atp5 (homo sapiens) (aka atp synthase peripheral stalk subunit f6)
E: atp5o (homo... | [E] |
<Instruct>: Given the context 'This ATP5O subunit is a key structural component of the stalk of the mitochondrial respiratory chain F1F0-ATP synthase and as such may contribute in a gene dosage-dependent manner to the phenotype of Down syndrome (trisomy 21).', select the correct biomedical concept for each mention usin... | <Mentions>: [atp5o]
<Options>: A: atp5lp5 (homo sapiens) (aka atp synthase membrane subunit g pseudogene 5)
B: atp5po (homo sapiens) (aka atp synthase peripheral stalk subunit oscp)
C: atp5i (homo sapiens) (aka atp synthase membrane subunit e)
D: atp5j (homo sapiens) (aka atp synthase peripheral stalk subunit f6)
E: at... | [B] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: carbonic anhydrase 5a, mitochondrial (mus musculus) (aka carbonic anhydrase 5a, mitochondrial)
B: ca5b (xenopus laevis) (aka carbonic anhydrase vb, mitochondrial l homeolog)
C: carbonic anhydrase 5b (homo sapiens) (aka carbo... | [F; F; F; F] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: carbonic anhydrase 5a, mitochondrial-like (homo sapiens) (aka carbonic anhydrase 5a, mitochondrial-like)
B: ca5b (homo sapiens) (aka carbonic anhydrase 5b)
C: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
D: c... | [K; K; K; K] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: ca5b (xenopus laevis) (aka carbonic anhydrase vb, mitochondrial l homeolog)
B: ca7.5 (mus musculus) (aka dna segment, ca7.5)
C: carbonic anhydrase 5a, mitochondrial (mus musculus) (aka carbonic anhydrase 5a, mitochondrial)
D... | [D; D; D; D] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: carbonic anhydrase 5a, mitochondrial-like (homo sapiens) (aka carbonic anhydrase 5a, mitochondrial-like)
B: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
C: ca5b (xenopus laevis) (aka carbonic anhydrase vb, mi... | [F; F; F; F] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: carbonic anhydrase 5a, mitochondrial-like (homo sapiens) (aka carbonic anhydrase 5a, mitochondrial-like)
B: ca5b (homo sapiens) (aka carbonic anhydrase 5b)
C: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
D: carbonic anhyd... | [M; M; M; M] |
<Instruct>: Given the context 'It is of interest for its putative roles in providing bicarbonate to carbamoyl phosphate synthetase for ureagenesis and to pyruvate carboxylase for gluconeogenesis and its possible importance in explaining certain inherited metabolic disorders with hyperammonemia and hypoglycemia.', selec... | <Mentions>: [pyruvate carboxylase]
<Options>: A: pc (oryctolagus cuniculus) (pyruvate carboxylase (oryctolagus cuniculus)) (aka pyruvate carboxylase)
B: pyruvate carboxylase (xenopus tropicalis) (aka pyruvate carboxylase)
C: pyruvate carboxylase (sus scrofa) (aka pyruvate carboxylase)
D: pc (homo sapiens) (pyruvate car... | [D] |
<Instruct>: Given the context 'Following the recent characterization of the cDNA for human CA V, we report the isolation of the human gene from two lambda genomic libraries and its characterization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [ca v]
<Options>: A: ca5b (homo sapiens) (aka carbonic anhydrase 5b)
B: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
C: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
D: carbonic anhydrase 5a (homo sapiens) (aka carbonic anhydrase 5a)
E: coagulation factor v (homo sapiens) (aka coagulation factor v)
F: ... | [D] |
<Instruct>: Given the context 'The CA V gene (CA5) is approximately 50 kb long and contains 7 exons and 6 introns.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ca v; ca5]
<Options>: A: ca5b (xenopus laevis) (aka carbonic anhydrase vb, mitochondrial l homeolog)
B: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
C: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
D: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
E: ca5a (homo sapiens) (aka carbonic anh... | [E; E] |
<Instruct>: Given the context 'The CA V gene (CA5) is approximately 50 kb long and contains 7 exons and 6 introns.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ca v; ca5]
<Options>: A: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
B: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
C: carbonic anhydrase 5b (homo sapiens) (aka carbonic anhydrase 5b)
D: ca-vi (homo sapiens) (aka carbonic anhydrase 6)
E: ca5b (homo sapiens) (aka carbonic anhydrase 5b)
... | [G; G] |
<Instruct>: Given the context 'The exon-intron boundaries are found in positions identical to those determined for the previously described CA II, CA III, and CA VII genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [ca ii; ca iii; ca vii]
<Options>: A: ca-ii (homo sapiens) (aka carbonic anhydrase 2)
B: ca-viii (homo sapiens) (aka carbonic anhydrase 8)
C: caiii (homo sapiens) (aka carbonic anhydrase 3)
D: cn-iii (homo sapiens) (aka 5'-nucleotidase, cytosolic iiia)
E: carbonic anhydrase 7 (homo sapiens) (aka carbonic an... | [A; K; E] |
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