instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [pthrp]
<Options>: A: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
B: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
C: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
D: pthrp (bos taurus) (aka p... | [C] |
<Instruct>: Given the context 'These findings have critical implications regarding the role of PTHrP in breast cancer, and they suggest that controlling PTHrP production in breast cancer may be useful therapeutically.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [pthrp]
<Options>: A: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: pthrp (bos taurus) (aka parathyroid hormone like hormone)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 ho... | [E] |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p-selectin ligand; psgl-1]
<Options>: A: selectin e (homo sapiens) (aka selectin e)
B: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
C: selectin p (homo sapiens) (aka selectin p)
D: cd62l (homo sapiens) (aka selectin l)
E: psg5 (homo sapiens) (aka pregnancy specific beta-1-glycoprotei... | [F; F] |
<Instruct>: Given the context 'Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p-selectin ligand; psgl-1]
<Options>: A: selectin p ligand (homo sapiens) (aka selectin p ligand)
B: selectin e (homo sapiens) (aka selectin e)
C: selectin p ligand (sus scrofa) (aka selectin p ligand)
D: psbg-1 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 1)
E: psg1 (homo sapiens) (pregnancy... | [A; A] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: selectin p (homo sapiens) (aka selectin p)
B: selectin e (homo sapiens) (aka selectin e)
C: selectin p ligand (sus scrofa) (aka selectin p ligand)
D: psg5 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 5)
E: psgb-5-1 (homo sapien... | [A; J; J] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
B: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
C: psgb-5-1 (homo sapiens) (aka cytochrome b5 ... | [K; J; J] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: psg1 (homo sapiens) (pregnancy specific beta-1-glycoprotein 7 (homo sapiens)) (aka pregnancy specific beta-1-glycoprotein 7)
B: selectin p (sus scrofa) (aka selectin p)
C: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
D... | [J; K; K] |
<Instruct>: Given the context 'Monoclonal antibodies against the P-selectin binding domain of the leukocyte P-selectin glycoprotein ligand, PSGL-1, prevented HGE cell binding and infection, as did enzymatic digestion of PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [p-selectin; p-selectin glycoprotein ligand; psgl-1]
<Options>: A: selectin p ligand (homo sapiens) (aka selectin p ligand)
B: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
C: selectin e (homo sapiens) (aka selectin e)
D: selectin l (homo sapiens) (aka selectin l)
E: psg1 (homo sapiens)... | [F; A; A] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: fuct-vii (xenopus tropicalis) (aka fucosyltransferase 7 (alpha (1,3) fucosyltransferase))
B: alpha1,3-fucosyltransferase a (drosophila melanogaster) (aka alpha1,3-fucosyltransferase a)
C: fuc-tvii (rattus norvegicus) (aka fucosyltransferase 7)... | [G; L; L] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: fucosyltransferase 7 (homo sapiens) (aka fucosyltransferase 7)
B: fucosyltransferase 9 (alpha (1,3) fucosyltransferase) (xenopus tropicalis) (aka fucosyltransferase 9 (alpha (1,3) fucosyltransferase))
C: alpha2-fucosyltransferase (xenopus trop... | [E; A; A] |
<Instruct>: Given the context 'Furthermore, simultaneous neoexpression in nonsusceptible cells of complementary DNAs for both PSGL-1 and its modifying alpha-(1,3) fucosyltransferase, Fuc-TVII, allowed binding and infection by HGE.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [psgl-1; alpha-(1,3) fucosyltransferase; fuc-tvii]
<Options>: A: 3-fuct (drosophila melanogaster) (aka alpha1,3-fucosyltransferase a)
B: fuc-tvii (rattus norvegicus) (aka fucosyltransferase 7)
C: psgl1 (homo sapiens) (aka selectin p ligand)
D: fuct-vii (xenopus laevis) (aka fucosyltransferase 7 (alpha (1,3)... | [C; F; F] |
<Instruct>: Given the context 'Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [psgl-1]
<Options>: A: psgl-1 (homo sapiens) (aka selectin p ligand)
B: psggb (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 6)
C: psg4 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 4)
D: psg3 (homo sapiens) (aka pregnancy specific beta-1-glycoprotein 3)
E: psbg-1 (homo sapiens) (ak... | [A] |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: thymine dna glycosylase (mus musculus) (aka thymine dna glycosylase)
B: dna-3-methyladenine glycosylase 1-like (glycine max) (aka dna-3-methyladenine glycosylase 1-like)
C: mgp (homo sapiens) (aka matrix gla protein)
D: 8-oxoguanine dna-glycosylase 1 (mus... | [I; I] |
<Instruct>: Given the context '3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: n-methylpurine-dna glycosylase (mus musculus) (aka n-methylpurine-dna glycosylase)
B: muty dna glycosylase (mus musculus) (aka muty dna glycosylase)
C: ppg (mus musculus) (aka glucagon)
D: mgp (homo sapiens) (aka matrix gla protein)
E: mpg (mus musculus) ... | [H; H] |
<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: n-methylpurine-dna glycosylase (mus musculus) (aka n-methylpurine-dna glycosylase)
B: mgp (mus musculus) (aka matrix gla protein)
C: muty dna glycosylase (mus musculus) (aka muty dna glycosylase)
D: mpg-1 (homo sapiens) (aka macrophage expressed 1)
E: mpg... | [F; F] |
<Instruct>: Given the context 'Human 3-methyladenine-DNA glycosylase (MPG protein) initiates base excision repair by severing the glycosylic bond of numerous damaged bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [3-methyladenine-dna glycosylase; mpg]
<Options>: A: n-methylpurine dna glycosylase (homo sapiens) (aka n-methylpurine dna glycosylase)
B: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
C: ppg (mus musculus) (aka glucagon)
D: thymine dna glycosylase (mus musculus) (aka thymin... | [A; A] |
<Instruct>: Given the context 'In comparison, homologues of the Rad23 proteins (hHR23) and the hXPC protein are involved in the recognition of damaged bases in global genome repair, a subset of nucleotide excision repair.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [hxpc]
<Options>: A: cphx (homo sapiens) (aka tmem254 antisense rna 1)
B: hcypx (homo sapiens) (aka peptidylprolyl isomerase like 1)
C: hcph (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 6)
D: hypc (xenopus tropicalis) (aka pre-mrna processing factor 40 homolog a)
E: hpcx (homo sapiens)... | [F] |
<Instruct>: Given the context 'In this report, we show that the hHR23A and -B also interact with the MPG protein and can serve as accessory proteins for DNA damage recognition in base excision repair.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [mpg]
<Options>: A: ppg (mus musculus) (aka glucagon)
B: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
C: mgp (mus musculus) (aka matrix gla protein)
D: mp (mus musculus) (aka micropinna microphthalmia)
E: mpg (oryctolagus cuniculus) (aka n-methylpurine dna glycosylase)
F: None of the above. | [B] |
<Instruct>: Given the context 'Furthermore, the MPG.hHR23 protein complex elevates the rate of MPG protein-catalyzed excision from hypoxanthine-containing substrates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [mpg]
<Options>: A: mgp (mus musculus) (aka matrix gla protein)
B: mpg (mus musculus) (aka n-methylpurine-dna glycosylase)
C: mp (mus musculus) (aka micropinna microphthalmia)
D: mpg-1 (homo sapiens) (aka macrophage expressed 1)
E: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
F: None of the above... | [E] |
<Instruct>: Given the context 'This increased excision rate is correlated with a greater binding affinity of the MPG protein-hHR23 protein complex for damaged DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mpg]
<Options>: A: mgp (homo sapiens) (aka matrix gla protein)
B: mp (mus musculus) (aka micropinna microphthalmia)
C: mpg (homo sapiens) (aka n-methylpurine dna glycosylase)
D: mpg-1 (mus musculus) (aka macrophage expressed gene 1)
E: mgp (mus musculus) (aka matrix gla protein)
F: None of the above. | [C] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: mxra2 (homo sapiens) (aka parvin alpha)
B: htpcr2 (homo sapiens) (aka olfactory receptor family 7 subfamily a member 5)
C: thralpha2 (homo sapiens) (aka thyroid hormone receptor alpha)
D: om (mus musculus) (aka ovum mutant)
E: om-1 (mus musculus) (aka importin 8)
F: antx... | [K; K; K] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: htra serine peptidase 2 (sus scrofa) (aka htra serine peptidase 2)
B: omm (drosophila melanogaster) (aka ommatoreductum)
C: htra serine peptidase 2 (mus musculus) (aka htra serine peptidase 2)
D: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
E: tra2a (homo sap... | [H; H; H] |
<Instruct>: Given the context 'Expression, purification, and functional analysis of the human serine protease HtrA2.
HumHtrA2 or Omi is a recently described member of a novel family of mammalian serine proteases homologous to the Escherichia coli htrA gene product.', select the correct biomedical concept for each menti... | <Mentions>: [htra2; humhtra2; omi]
<Options>: A: thralpha2 (homo sapiens) (aka thyroid hormone receptor alpha)
B: htr2a (homo sapiens) (aka 5-hydroxytryptamine receptor 2a)
C: htra2-beta (homo sapiens) (aka transformer 2 beta homolog)
D: omi (mus musculus) (aka htra serine peptidase 2)
E: thrap2 (homo sapiens) (aka med... | [F; F; F] |
<Instruct>: Given the context 'In this report we describe the overexpression of humHtrA2 in two heterologous systems comparing the merits of each.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humhtra2]
<Options>: A: hthtr2 (homo sapiens) (aka solute carrier family 19 member 3)
B: htpcr2 (homo sapiens) (aka olfactory receptor family 7 subfamily a member 5)
C: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
D: antxr2 (homo sapiens) (aka antxr cell adhesion molecule 2)
E: atoh2 (homo... | [F] |
<Instruct>: Given the context 'By means of fluorescently labeled substrates alpha- and beta-casein and zymography, the proteolytic activity of recombinant HumHtrA2 was also demonstrated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [humhtra2]
<Options>: A: hthtr2 (homo sapiens) (aka solute carrier family 19 member 3)
B: atoh2 (homo sapiens) (aka neuronal differentiation 6)
C: arb2a (homo sapiens) (aka arb2 cotranscriptional regulator a)
D: antxr2 (homo sapiens) (aka antxr cell adhesion molecule 2)
E: thrap2 (homo sapiens) (aka mediato... | [F] |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [il-2; p21snft]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
D: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
E: colony stimula... | [H; C] |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [il-2; p21snft]
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: nst1 (saccharomyces cerevisiae s288c) (aka nst1p)
C: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
D: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subuni... | [F; J] |
<Instruct>: Given the context 'Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.
IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [il-2; p21snft]
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3)
B: il-2 (homo sapiens) (aka interleukin 2)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
E: cstf2t (rattus norvegicus) (aka clea... | [B; J] |
<Instruct>: Given the context 'The inducible expression of IL-2 is highly regulated by multiple transcription factors, particularly AP-1, which coordinately activate the promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [il-2]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
C: interleukin 2 (homo sapiens) (aka interleukin 2)
D: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
E: interleukin 3 (homo sapiens) (aka interleukin 3)
F: No... | [C] |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [p21snft; il-2]
<Options>: A: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
B: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
C: interleukin 3 (homo sapiens) (aka interleukin 3)
D: nft1 (saccharomyces cerevisiae s288c) (uncha... | [A; J] |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [p21snft; il-2]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: nst1 (saccharomyces cerevisiae s288c) (aka nst1p)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
E: snft (homo sapiens) (aka basic leucine zippe... | [E; H] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: il-2 (homo sapiens) (aka interleukin 2)
B: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
C: jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subun... | [K; A; C; O] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
B: interleukin 3 (homo sapiens) (aka interleukin 3)
C: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
D: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit... | [A; T; E; Q] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
B: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized protein)
C: interleukin 3 (homo sapiens) (aka interleukin 3)
D: c-fos ... | [Q; E; F; N] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
B: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: fos like 2, ap-1 transcription fac... | [T; Q; O; R] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct... | <Mentions>: [jun]
<Options>: A: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: juno (homo sapiens) (aka izumo1 receptor, juno)
D: jund proto-oncogene, ap-1 transcription f... | [E] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biom... | <Mentions>: [p21snft; jun; il-2]
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: jun (mus musculus) (aka jun proto-oncogene)
C: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
D: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
E: juno (hom... | [I; F; J] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biom... | <Mentions>: [p21snft; jun; il-2]
<Options>: A: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
D: interleukin 3 (homo sapiens) (aka interleukin 3)
E: interleukin enhancer b... | [L; G; K] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biom... | <Mentions>: [p21snft; jun; il-2]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
C: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
D: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)... | [F; K; N] |
<Instruct>: Given the context 'Identification of distinct surface-expressed and intracellular CXC-chemokine receptor 2 glycoforms in neutrophils: N-glycosylation is essential for maintenance of receptor surface expression.
', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [cxc-chemokine receptor 2]
<Options>: A: c-x-c motif chemokine receptor 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 2)
B: c-x-c motif chemokine receptor 1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
C: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2... | [E] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: neutrophil cytosolic factor 2 (homo sapiens) (aka neutrophil cytosolic factor 2)
C: c-x-c motif chemokine ligand 2 (homo sapiens) (aka c-x-c motif chemokine ... | [L; I; F; F] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: x-c motif chemokine ligand 2 (homo sapiens) (aka x-c motif chemokine ligand 2)
B: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
C: il18 (homo sapiens) (aka interleukin 18)
D: fgf-8 (homo sapiens) (aka fibroblast growth factor... | [F; P; Q; Q] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
B: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: nipsnap homolog 2 (xenopus tropicalis)... | [J; G; Q; Q] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
C: prokineticin 2 (homo sapiens) (aka prokineticin 2)
D: c-x-c motif chemokine ligand 8 (... | [H; D; I; I] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: il1f8 (homo sapiens) (aka interleukin 36 beta)
C: neutrophil cytosolic factor 2 (homo sapiens) (aka neutrophil cytosolic factor 2)
D: c-c motif chemokine... | [Q; O; J; J] |
<Instruct>: Given the context 'Although CXCR-2 has been successfully cloned and expressed in several cell lines, the molecular properties of the native neutrophil-expressed receptor have remained largely undefined.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [cxcr-2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'Here we report on the identification and characterization of distinct CXCR-2 glycoforms and their subcellular distribution in neutrophils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [cxcr-2]
<Options>: A: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
D: None of the above. | [A] |
<Instruct>: Given the context 'Here we report on the identification and characterization of distinct CXCR-2 glycoforms and their subcellular distribution in neutrophils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [cxcr-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
C: None of the above. | [C] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention u... | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
B: nap-2 (homo sapiens) (aka pro-platelet basic protein)
C: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
D: c-x-c motif chemokine... | [D; B; G] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention u... | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: cxcl8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
B: nap-2 (homo sapiens) (aka pro-platelet basic protein)
C: il1f8 (homo sapiens) (aka interleukin 36 beta)
D: nac-2 (homo sapiens) (aka nacc family member 2)
E: nap2 (homo sapiens) (napsin b aspartic peptidase (pse... | [A; B; L] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention u... | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
D: il18 (homo sapiens) (aka interleukin 1... | [L; G; I] |
<Instruct>: Given the context 'According to deglycosylation experiments surface-expressed CXCR-2 carries two N-linked 9-kDa carbohydrate moieties that are both of complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [cxcr-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'According to deglycosylation experiments surface-expressed CXCR-2 carries two N-linked 9-kDa carbohydrate moieties that are both of complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [cxcr-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: None of the above. | [C] |
<Instruct>: Given the context 'In addition, two other CXCR-2 variants of 38 and 40 kDa were found to occur exclusively intracellular and to carry N-glycosylations of high mannose or hybrid type.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [cxcr-2]
<Options>: A: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: None of the above. | [C] |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: nap-2 (homo sapiens) (aka pro-platelet basic protein)
C: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
D: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapi... | [E; B] |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
C: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
D: nap2l (homo sapiens) (aka nucleosome assembly protein 1 ... | [H; E] |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: nap-2 (homo sapiens) (aka pro-platelet basic protein)
B: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
C: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
E: ... | [C; A] |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [cxcr-2; nap-2]
<Options>: A: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: nap-2 (homo sapiens) (aka pro-platelet basic protein)
C: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
D: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
E:... | [E; B] |
<Instruct>: Given the context 'Instead, glycosylation was found to protect CXCR-2 from proteolytic attack, as even partial deglycosylation is associated with serine protease-mediated disappearance of the receptor from the neutrophil surface.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [cxcr-2]
<Options>: A: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
B: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'Instead, glycosylation was found to protect CXCR-2 from proteolytic attack, as even partial deglycosylation is associated with serine protease-mediated disappearance of the receptor from the neutrophil surface.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [cxcr-2]
<Options>: A: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
B: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
C: None of the above. | [C] |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [trek2; 2p domain mechano-sensitive k+ channel]
<Options>: A: potassium two pore domain channel subfamily k member 4 (homo sapiens) (aka potassium two pore domain channel subfamily k member 4)
B: katp-2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 6)
C: trek (homo sapiens) (a... | [I; I] |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [trek2; 2p domain mechano-sensitive k+ channel]
<Options>: A: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: kcnc2 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 2)
C: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k me... | [G; G] |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; trek1]
<Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek-1 (mus musculus) ... | [C; B] |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; trek1]
<Options>: A: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek-1 (mus musculus)... | [A; C] |
<Instruct>: Given the context 'TREK2 is abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [trek2]
<Options>: A: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: tresk2 (homo sapiens) (aka pot... | [A] |
<Instruct>: Given the context 'In the central nervous system, TREK2 has a widespread distribution with the highest levels of expression in cerebellum, occipital lobe, putamen, and thalamus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [trek2]
<Options>: A: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek (homo sapiens) ... | [A] |
<Instruct>: Given the context 'In the central nervous system, TREK2 has a widespread distribution with the highest levels of expression in cerebellum, occipital lobe, putamen, and thalamus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [trek2]
<Options>: A: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: tresk-2 (homo sapiens)... | [E] |
<Instruct>: Given the context 'In transfected cells, TREK2 produces rapidly activating and non-inactivating outward rectifier K(+) currents.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: trek1 (homo sapiens) (aka... | [C] |
<Instruct>: Given the context 'TREK2 is blocked by application of intracellular cAMP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-2 (xenopus tropicalis) ... | [E] |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [trek1; trek2]
<Options>: A: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
C: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: tresk-2 (homo sapiens) (aka potassi... | [G; H] |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [trek1; trek2]
<Options>: A: trek-1 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 2)
B: task-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
C: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek2 (homo sap... | [C; D] |
<Instruct>: Given the context 'TREK2 can be positively or negatively regulated by a variety of neurotransmitter receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: trek1 (homo sapien... | [B] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: 5-hydroxytryptamine receptor 4 (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
C: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: glur-... | [M; F; E; I] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: mglur1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: mglur1 (homo sapiens) (aka glutamate metabotropic receptor 1)
D: glurr2 (homo sapiens) (aka polr2m pseudo... | [R; C; I; H] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: corticotropin releasing hormone receptor 2 (mus musculus) (aka corticotropin releasing hormone receptor 2)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: htr4 (rattus norvegicus) (aka 5-hydroxytryptamine recepto... | [D; M; Q; J] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: sstr4 (homo sapiens) (aka somatostatin receptor 4)
B: gpr2 (homo sapiens) (aka c-c motif chemokine receptor 10)
C: grm2 (homo sapiens) (aka glutamate metabotropic receptor 2)
D: 5-hydroxytryptamine receptor 4 (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
E: ... | [J; T; C; R] |
<Instruct>: Given the context 'These multiple types of regulations suggest that TREK2 plays an important role as a target of neurotransmitter action.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
D: task-2 (homo sapie... | [B] |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [shp2; interleukin-6]
<Options>: A: interleukin 6 (homo sapiens) (aka interleukin 6)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif in... | [F; A] |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [shp2; interleukin-6]
<Options>: A: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
D: interleukin 6 (homo sapiens) (aka interleukin 6)
E: pt... | [F; D] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: pdpk2 (homo sapiens) (aka 3-phosphoinositide dependent protein kinase 1)
B: pyk2 (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
C: pyk2 (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) ... | [J; J; J; E] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
B: pdpk2 (homo sapiens) (aka 3-phosphoinositide dependent protein kinase 1)
C: il7 (homo sapiens) (aka interleukin 7)
D: frk (bos taurus) (aka fyn related ... | [O; O; O; K] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: fak2 (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: hbgf-6 (homo sapiens) (ak... | [C; C; C; F] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: tyk2 (homo sapiens) (aka tyrosine kinase 2)
B: pank2 (homo sapiens) (aka pantothenate kinase 2)
C: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
D: frnk (homo sapiens) (aka protein tyrosine kinase 2)
E... | [P; P; P; N] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: pyk (homo sapiens) (aka phosphorylase kinase regulatory subunit alpha 2)
B: pyk-2 (caenorhabditis elegans) (aka pyruvate kinase)
C: frk (bos taurus) (aka fyn related src family tyrosine kinase)
D: raftk (homo sapiens) (aka pr... | [D; D; D; G] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [il-6; raftk]
<Options>: A: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
B: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
C: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
D: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interl... | [D; I] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cell... | <Mentions>: [il-6; raftk]
<Options>: A: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
B: frk (bos taurus) (aka fyn related src family tyrosine kinase)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
E: frk (xenopus tropicalis) (aka... | [G; C] |
<Instruct>: Given the context 'However, the mechanism whereby IL-6 inhibits Dex-induced apoptosis is undefined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6]
<Options>: A: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
B: interleukin 7 (homo sapiens) (aka interleukin 7)
C: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
D: cdf (homo sapiens) (interleukin 6 (homo sapi... | [D] |
<Instruct>: Given the context 'In this study, we demonstrate that protein-tyrosine phosphatase SHP2 mediates this protective effect.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2]
<Options>: A: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: ptpn2... | [E] |
<Instruct>: Given the context 'In this study, we demonstrate that protein-tyrosine phosphatase SHP2 mediates this protective effect.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2]
<Options>: A: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: ptpn12 (homo sapiens) (aka protein ... | [E] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
B: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: protein tyrosine phosphatase non-receptor ty... | [I; B; M] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: frnk (homo sapiens) (aka protein tyrosine kinase 2)
B: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: hbgf-6 (homo sapiens) (aka ... | [E; H; M] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: frk (drosophila melanogaster) (aka franklin)
C: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
D: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
E: ptpn12 (homo sapiens) (aka protein tyrosine p... | [I; A; L] |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; raftk]
<Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: raftk (xenopus tro... | [I; C] |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; raftk]
<Options>: A: frnk (homo sapiens) (aka protein tyrosine kinase 2)
B: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
D: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: ptpn2p... | [D; B] |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [raftk; shp2]
<Options>: A: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
D: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
E:... | [F; A] |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [raftk; shp2]
<Options>: A: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: frk (bos taurus) (aka fyn related src family tyrosine kinase)
C: frnk (homo sapiens) (aka protein tyrosine kinase 2)
D: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
E: raftk (homo sapiens) (aka protein tyrosine... | [E; J] |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [shp2; il-6]
<Options>: A: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: fibroblast growth factor 6 (homo sa... | [G; E] |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [shp2; il-6]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
C: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
D: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
E: ptp1... | [B; G] |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [shp2; il-6]
<Options>: A: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
B: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: ptpn2p (homo sapiens) (aka pt... | [H; E] |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [shp2; il-6]
<Options>: A: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
D: hbgf-6 ... | [A; H] |
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