instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fos; jun; il-2]
<Options>: A: c-fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
B: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
C: il22 (homo sapiens) (aka interleukin 22)
D: fos like 1, ap-1 transcription factor subunit (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
E: fos (mus musculus) (aka fbj osteosarcoma oncogene)
F: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
G: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
H: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
I: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
J: jun (mus musculus) (aka jun proto-oncogene)
K: jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
L: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
M: il2 (homo sapiens) (aka interleukin 2)
N: juno (homo sapiens) (aka izumo1 receptor, juno)
O: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
P: None of the above. | [A; K; M] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fos; jun; il-2]
<Options>: A: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
D: il-2 (homo sapiens) (aka interleukin 2)
E: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
F: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
G: juno (homo sapiens) (aka izumo1 receptor, juno)
H: fos (mus musculus) (aka fbj osteosarcoma oncogene)
I: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
J: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
K: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
L: fra (homo sapiens) (fos like 1, ap-1 transcription factor subunit (homo sapiens)) (aka fos like 1, ap-1 transcription factor subunit)
M: il22 (homo sapiens) (aka interleukin 22)
N: interleukin 3 (homo sapiens) (aka interleukin 3)
O: ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)) (aka jun proto-oncogene, ap-1 transcription factor subunit)
P: None of the above. | [K; O; D] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fos; jun; il-2]
<Options>: A: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
B: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
C: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
D: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
E: fra (homo sapiens) (fos like 1, ap-1 transcription factor subunit (homo sapiens)) (aka fos like 1, ap-1 transcription factor subunit)
F: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
G: interleukin 3 (homo sapiens) (aka interleukin 3)
H: il22 (homo sapiens) (aka interleukin 22)
I: ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)) (aka jun proto-oncogene, ap-1 transcription factor subunit)
J: juno (homo sapiens) (aka izumo1 receptor, juno)
K: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
L: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
M: fos (mus musculus) (aka fbj osteosarcoma oncogene)
N: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
O: None of the above. | [F; I; O] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fos; jun; il-2]
<Options>: A: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: il-2 (homo sapiens) (aka interleukin 2)
D: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
E: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
F: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
G: juno (homo sapiens) (aka izumo1 receptor, juno)
H: fos (mus musculus) (aka fbj osteosarcoma oncogene)
I: ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)) (aka jun proto-oncogene, ap-1 transcription factor subunit)
J: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
K: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
L: interleukin 3 (homo sapiens) (aka interleukin 3)
M: fosl1 (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
N: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
O: csf2 (homo sapiens) (aka colony stimulating factor 2)
P: None of the above. | [A; I; C] |
<Instruct>: Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-fos]
<Options>: A: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
B: c-fos (xenopus tropicalis) (aka fbj murine osteosarcoma viral oncogene homolog)
C: fos like 1, ap-1 transcription factor subunit (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
D: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
E: c-fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
F: None of the above. | [E] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: cd2 (bos taurus) (aka cd2 molecule)
B: cd228 (homo sapiens) (aka melanotransferrin)
C: csf2 (homo sapiens) (aka colony stimulating factor 2)
D: il-2 (homo sapiens) (aka interleukin 2)
E: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
F: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
G: cd21 (homo sapiens) (aka complement c3d receptor 2)
H: interleukin 3 (homo sapiens) (aka interleukin 3)
I: cd2 (homo sapiens) (aka cd2 molecule)
J: cd22 molecule (homo sapiens) (aka cd22 molecule)
K: None of the above. | [I; D] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd2 (gallus gallus) (aka cd2 molecule)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: interleukin 2 (homo sapiens) (aka interleukin 2)
F: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
G: interleukin 3 (homo sapiens) (aka interleukin 3)
H: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
I: cd228 (homo sapiens) (aka melanotransferrin)
J: cd2 molecule (homo sapiens) (aka cd2 molecule)
K: None of the above. | [J; E] |
<Instruct>: Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: cd228 (homo sapiens) (aka melanotransferrin)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: cd2 molecule (bos taurus) (aka cd2 molecule)
F: None of the above. | [A] |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd21 (homo sapiens) (aka complement c3d receptor 2)
B: cd2 molecule (bos taurus) (aka cd2 molecule)
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: None of the above. | [D] |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd228 (homo sapiens) (aka melanotransferrin)
D: cd2 molecule (bos taurus) (aka cd2 molecule)
E: None of the above. | [E] |
<Instruct>: Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: cd2 molecule (bos taurus) (aka cd2 molecule)
C: cd2 (homo sapiens) (aka cd2 molecule)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: None of the above. | [C] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
B: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
C: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
D: mtor (mus musculus) (aka mechanistic target of rapamycin kinase)
E: mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
F: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
G: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase)
H: None of the above. | [H; H] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
B: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
C: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
D: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
E: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase)
F: mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
G: mechanistic target of rapamycin kinase (homo sapiens) (aka mechanistic target of rapamycin kinase)
H: None of the above. | [H; H] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: alpha kinase 1 (homo sapiens) (aka alpha kinase 1)
B: ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 2 (homo sapiens)) (aka protein kinase amp-activated catalytic subunit alpha 2)
C: protein kinase camp-activated catalytic subunit alpha (homo sapiens) (aka protein kinase camp-activated catalytic subunit alpha)
D: protein kinase amp-activated catalytic subunit alpha 1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
E: ampkalpha2 (mus musculus) (aka protein kinase, amp-activated, alpha 2 catalytic subunit)
F: ampka2 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 2)
G: ampk alpha 1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
H: ampkalpha1 (mus musculus) (aka protein kinase, amp-activated, alpha 1 catalytic subunit)
I: prkar2a (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit alpha)
J: alpha kinase 2 (homo sapiens) (aka alpha kinase 2)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: prkaa1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
B: ampka1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
C: alpha kinase 1 (homo sapiens) (aka alpha kinase 1)
D: prkaca (homo sapiens) (protein kinase camp-activated catalytic subunit alpha (homo sapiens)) (aka protein kinase camp-activated catalytic subunit alpha)
E: protein kinase amp-activated catalytic subunit alpha 2 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 2)
F: ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 2 (homo sapiens)) (aka protein kinase amp-activated catalytic subunit alpha 2)
G: ampkalpha2 (mus musculus) (aka protein kinase, amp-activated, alpha 2 catalytic subunit)
H: alpha kinase 2 (homo sapiens) (aka alpha kinase 2)
I: prkar2a (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit alpha)
J: ampkalpha1 (mus musculus) (aka protein kinase, amp-activated, alpha 1 catalytic subunit)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: ribosomal protein s6 kinase a6 (homo sapiens) (aka ribosomal protein s6 kinase a6)
B: torc1 (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
C: ribosomal protein s6 kinase polypeptide 6 (mus musculus) (aka ribosomal protein s6 kinase polypeptide 6)
D: s6kbeta (homo sapiens) (aka ribosomal protein s6 kinase b2)
E: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
F: rps6ka1 (homo sapiens) (aka ribosomal protein s6 kinase a1)
G: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
H: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
I: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
J: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
K: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase)
L: None of the above. | [L; L; L] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: mechanistic target of rapamycin (drosophila melanogaster) (aka mechanistic target of rapamycin)
B: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
C: p70-s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
D: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
E: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
F: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
G: rps6ka6 (homo sapiens) (aka ribosomal protein s6 kinase a6)
H: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase)
I: ribosomal protein s6 kinase polypeptide 6 (mus musculus) (aka ribosomal protein s6 kinase polypeptide 6)
J: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
K: rps6ka1 (homo sapiens) (aka ribosomal protein s6 kinase a1)
L: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
M: None of the above. | [M; M; M] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: p70-s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
B: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
C: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
D: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
E: ribosomal protein s6 kinase polypeptide 6 (mus musculus) (aka ribosomal protein s6 kinase polypeptide 6)
F: mechanistic target of rapamycin (drosophila melanogaster) (aka mechanistic target of rapamycin)
G: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
H: torc1 (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
I: rps6ka6 (homo sapiens) (aka ribosomal protein s6 kinase a6)
J: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase)
K: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
L: mechanistic target of rapamycin kinase (homo sapiens) (aka mechanistic target of rapamycin kinase)
M: rps6ka1 (homo sapiens) (aka ribosomal protein s6 kinase a1)
N: None of the above. | [N; N; N] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eif4ep1 (homo sapiens) (aka eukaryotic translation initiation factor 4e pseudogene 1)
B: eukaryotic translation initiation factor 4e (xenopus tropicalis) (aka eukaryotic translation initiation factor 4e)
C: eif4f (homo sapiens) (eukaryotic translation initiation factor 4 gamma 1 (homo sapiens)) (aka eukaryotic translation initiation factor 4 gamma 1)
D: eif4gl (homo sapiens) (aka cwc22 spliceosome associated protein)
E: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
F: eif4e (xenopus laevis) (eukaryotic translation initiation factor 4e l homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4e l homeolog)
G: eif4g (drosophila melanogaster) (eukaryotic translation initiation factor 4g2 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4g2)
H: eif4g (xenopus laevis) (eukaryotic translation initiation factor 4 gamma, 1 s homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4 gamma, 1 s homeolog)
I: eif4c (homo sapiens) (aka eukaryotic translation initiation factor 1a x-linked)
J: eif4e (drosophila melanogaster) (eukaryotic translation initiation factor 4e homologous protein (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e homologous protein)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eif4c (homo sapiens) (aka eukaryotic translation initiation factor 1a x-linked)
B: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
C: eif4e (xenopus tropicalis) (eukaryotic translation initiation factor 4e (xenopus tropicalis)) (aka eukaryotic translation initiation factor 4e)
D: eif4ep1 (homo sapiens) (aka eukaryotic translation initiation factor 4e pseudogene 1)
E: eif4g (homo sapiens) (aka eukaryotic translation initiation factor 4 gamma 1)
F: eif4e (drosophila melanogaster) (eukaryotic translation initiation factor 4e1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e1)
G: eif4g (drosophila melanogaster) (eukaryotic translation initiation factor 4g1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4g1)
H: eif4g (xenopus tropicalis) (aka eukaryotic translation initiation factor 4 gamma, 1)
I: eif4e (xenopus laevis) (eukaryotic translation initiation factor 4e l homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4e l homeolog)
J: eif4g (xenopus laevis) (eukaryotic translation initiation factor 4 gamma, 1 s homeolog (xenopus laevis)) (aka eukaryotic translation initiation factor 4 gamma, 1 s homeolog)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'In contrast, eIF2B activity remained unchanged in response to AICAR treatment and therefore would not appear to contribute to the depression in protein synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif2b]
<Options>: A: eukaryotic translation initiation factor 2b subunit beta (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit beta)
B: eif2beta (homo sapiens) (aka eukaryotic translation initiation factor 2 subunit beta)
C: eif2b (drosophila melanogaster) (eukaryotic translation initiation factor 2b subunit beta (drosophila melanogaster)) (aka eukaryotic translation initiation factor 2b subunit beta)
D: eif2b (homo sapiens) (eukaryotic translation initiation factor 2b subunit alpha (homo sapiens)) (aka eukaryotic translation initiation factor 2b subunit alpha)
E: None of the above. | [E] |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: protocadherin 12 (homo sapiens) (aka protocadherin 12)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
E: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
F: None of the above. | [F] |
<Instruct>: Given the context 'The gene was predominantly expressed in liver, kidney and colon tissues, and was thus designated Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
D: protocadherin 1 (homo sapiens) (aka protocadherin 1)
E: protocadherin 12 (homo sapiens) (aka protocadherin 12)
F: None of the above. | [F] |
<Instruct>: Given the context 'The expression of Protocadherin LKC is markedly reduced in cancers arising from these tissues at both transcriptional and protein levels.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: protocadherin 10 (homo sapiens) (aka protocadherin 10)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: pcdhac (homo sapiens) (aka protocadherin alpha constant)
F: None of the above. | [F] |
<Instruct>: Given the context 'To investigate the effects of Protocadherin LKC expression in colon cancer, we introduced the gene into colon cancer cell line HCT116, which does not express this gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
F: None of the above. | [F] |
<Instruct>: Given the context 'Significantly, Protocadherin LKC expression induced contact inhibition of cell proliferation although it did not affect growth rate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: protocadherin 1 (homo sapiens) (aka protocadherin 1)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: pcdh7 (homo sapiens) (aka protocadherin 7)
F: None of the above. | [F] |
<Instruct>: Given the context 'When grown to post-confluence in monolayer cells cultures, Protocadherin LKC-expressing HCT116 no longer formed multiple cell layers and showed the typical paving stone morphology of normal epithelial cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
E: protocadherin 12 (homo sapiens) (aka protocadherin 12)
F: None of the above. | [F] |
<Instruct>: Given the context 'Furthermore, expression of Protocadherin LKC suppressed tumor formation of HCT116 cells in a nude mouse model.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: protocadherin 12 (homo sapiens) (aka protocadherin 12)
B: protocadherin 1 (homo sapiens) (aka protocadherin 1)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhac (homo sapiens) (aka protocadherin alpha constant)
E: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
F: None of the above. | [F] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: mast205 (drosophila melanogaster) (aka drop out)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: 205-kda map (drosophila melanogaster) (aka microtubule-associated protein 205)
D: transmembrane protein 205 (sus scrofa) (aka transmembrane protein 205)
E: protocadherin 12 (homo sapiens) (aka protocadherin 12)
F: ygr205w (saccharomyces cerevisiae s288c) (aka putative atp-dependent kinase)
G: microtubule associated serine/threonine kinase 1 (homo sapiens) (aka microtubule associated serine/threonine kinase 1)
H: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
I: protocadherin 1 (homo sapiens) (aka protocadherin 1)
J: tmem205 (mus musculus) (aka transmembrane protein 205)
K: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
L: pcdh7 (homo sapiens) (aka protocadherin 7)
M: mast205 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
N: None of the above. | [M; M; N] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: pcdhac (homo sapiens) (aka protocadherin alpha constant)
B: ygr205w (saccharomyces cerevisiae s288c) (aka putative atp-dependent kinase)
C: mast205 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: microtubule associated serine/threonine kinase 1 (homo sapiens) (aka microtubule associated serine/threonine kinase 1)
F: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
G: protocadherin 1 (homo sapiens) (aka protocadherin 1)
H: tmem205 (homo sapiens) (aka transmembrane protein 205)
I: mstp105 (homo sapiens) (aka early endosome antigen 1)
J: transmembrane protein 205 (sus scrofa) (aka transmembrane protein 205)
K: transmembrane protein 205 (mus musculus) (aka transmembrane protein 205)
L: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
M: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
N: tmem205 (xenopus tropicalis) (aka transmembrane protein 205)
O: None of the above. | [C; C; O] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: protocadherin 12 (homo sapiens) (aka protocadherin 12)
B: mast205 (drosophila melanogaster) (aka drop out)
C: tmem205 (homo sapiens) (aka transmembrane protein 205)
D: ygr205w (saccharomyces cerevisiae s288c) (aka putative atp-dependent kinase)
E: microtubule-associated protein 205 (drosophila melanogaster) (aka microtubule-associated protein 205)
F: pcdhac (homo sapiens) (aka protocadherin alpha constant)
G: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
H: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
I: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
J: mast205 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
K: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
L: microtubule associated serine/threonine kinase 1 (homo sapiens) (aka microtubule associated serine/threonine kinase 1)
M: tmem205 (sus scrofa) (aka transmembrane protein 205)
N: None of the above. | [J; J; N] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: protocadherin 10 (homo sapiens) (aka protocadherin 10)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: protocadherin 1 (homo sapiens) (aka protocadherin 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: pdz73 (homo sapiens) (aka ush1 protein network component harmonin)
B: pdzd1 (homo sapiens) (aka pdz domain containing 1)
C: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: pdz domain containing 7 (homo sapiens) (aka pdz domain containing 7)
F: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
G: protocadherin 7 (homo sapiens) (aka protocadherin 7)
H: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
I: pdz domain containing 1 (xenopus tropicalis) (aka pdz domain containing 1)
J: pdz domain-containing protein 9-like (xenopus tropicalis) (aka pdz domain-containing protein 9-like)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: pcdhac (homo sapiens) (aka protocadherin alpha constant)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: pdz domain containing 1 (homo sapiens) (aka pdz domain containing 1)
D: pdzx (homo sapiens) (aka magi family member, x-linked)
E: pdz domain containing 1 (xenopus tropicalis) (aka pdz domain containing 1)
F: pdzd4 (homo sapiens) (aka pdz domain containing 4)
G: pdz domain-containing protein 9-like (xenopus tropicalis) (aka pdz domain-containing protein 9-like)
H: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
I: protocadherin 10 (homo sapiens) (aka protocadherin 10)
J: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
B: daxx (mus musculus) (aka fas death domain-associated protein)
C: histone deacetylase 2 (homo sapiens) (aka histone deacetylase 2)
D: dek proto-oncogene (mus musculus) (aka dek proto-oncogene)
E: daxx (danio rerio) (aka death-domain associated protein)
F: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
G: dek (drosophila melanogaster) (eph receptor tyrosine kinase (drosophila melanogaster)) (aka eph receptor tyrosine kinase)
H: dek (danio rerio) (aka dek proto-oncogene)
I: daxx (drosophila melanogaster) (aka daxx-like protein)
J: histone deacetylase 7 (homo sapiens) (aka histone deacetylase 7)
K: daxx (homo sapiens) (aka death domain associated protein)
L: daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans) (aka daxx;spx domain-containing protein;uncharacterized protein)
M: dee2 (homo sapiens) (aka cyclin dependent kinase like 5)
N: dek proto-oncogene (homo sapiens) (aka dek proto-oncogene)
O: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
P: None of the above. | [K; C; N] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
C: daxx (xenopus tropicalis) (aka death-associated protein 6)
D: dek (homo sapiens) (aka dek proto-oncogene)
E: dek (mus musculus) (aka dek proto-oncogene)
F: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
G: dek (danio rerio) (aka dek proto-oncogene)
H: daxx (danio rerio) (aka death-domain associated protein)
I: dee (homo sapiens) (aka klk3 upstream enhancer/promoter region)
J: daxx (homo sapiens) (aka death domain associated protein)
K: dek (xenopus tropicalis) (aka dek proto-oncogene)
L: daxx (mus musculus) (aka fas death domain-associated protein)
M: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
N: hdac2 (homo sapiens) (aka histone deacetylase 2)
O: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
P: None of the above. | [J; N; D] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: dee (homo sapiens) (aka klk3 upstream enhancer/promoter region)
B: hdac2 (homo sapiens) (aka histone deacetylase 2)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: dek (xenopus tropicalis) (aka dek proto-oncogene)
E: daxx (xenopus tropicalis) (aka death-associated protein 6)
F: dek (danio rerio) (aka dek proto-oncogene)
G: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
H: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
I: dek (mus musculus) (aka dek proto-oncogene)
J: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
K: daxx (danio rerio) (aka death-domain associated protein)
L: daxx (homo sapiens) (aka death domain associated protein)
M: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
N: daxx (mus musculus) (aka fas death domain-associated protein)
O: None of the above. | [L; B; O] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: dek proto-oncogene (homo sapiens) (aka dek proto-oncogene)
B: dax1 (homo sapiens) (aka nuclear receptor subfamily 0 group b member 1)
C: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
D: dek (xenopus tropicalis) (aka dek proto-oncogene)
E: dek (danio rerio) (aka dek proto-oncogene)
F: daxx (homo sapiens) (aka death domain associated protein)
G: histone deacetylase 7 (homo sapiens) (aka histone deacetylase 7)
H: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
I: dee (homo sapiens) (aka klk3 upstream enhancer/promoter region)
J: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
K: dek (drosophila melanogaster) (eph receptor tyrosine kinase (drosophila melanogaster)) (aka eph receptor tyrosine kinase)
L: daxx (mus musculus) (aka fas death domain-associated protein)
M: rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens)) (aka histone deacetylase 2)
N: daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans) (aka daxx;spx domain-containing protein;uncharacterized protein)
O: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
P: None of the above. | [F; M; A] |
<Instruct>: Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [daxx]
<Options>: A: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
B: daxx (mus musculus) (aka fas death domain-associated protein)
C: dax1 (homo sapiens) (aka nuclear receptor subfamily 0 group b member 1)
D: daxx (homo sapiens) (aka death domain associated protein)
E: daxx (danio rerio) (aka death-domain associated protein)
F: None of the above. | [D] |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: adx (homo sapiens) (aka ferredoxin 1)
D: daxx (danio rerio) (aka death-domain associated protein)
E: daxx (homo sapiens) (aka death domain associated protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: hyrax (drosophila melanogaster) (aka hyrax)
C: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
D: axed on x (drosophila melanogaster) (aka axed on x)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated protein reported to change the topology of DNA in chromatin in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: hdac2 (homo sapiens) (aka histone deacetylase 2)
C: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
D: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
E: daxx (homo sapiens) (aka death domain associated protein)
F: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
G: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
H: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
I: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
J: axed on x (drosophila melanogaster) (aka axed on x)
K: None of the above. | [E; B] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated protein reported to change the topology of DNA in chromatin in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: daxx (homo sapiens) (aka death domain associated protein)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
E: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
F: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
G: daxx (drosophila melanogaster) (aka daxx-like protein)
H: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
I: hdac2 (homo sapiens) (aka histone deacetylase 2)
J: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
K: None of the above. | [B; I] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated protein reported to change the topology of DNA in chromatin in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
D: hdac2 (homo sapiens) (aka histone deacetylase 2)
E: axed on x (drosophila melanogaster) (aka axed on x)
F: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
G: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
H: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
I: adx (homo sapiens) (aka ferredoxin 1)
J: None of the above. | [J; D] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
D: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
E: axed on x (drosophila melanogaster) (aka axed on x)
F: daxx (xenopus tropicalis) (aka death-associated protein 6)
G: hyrax (drosophila melanogaster) (aka hyrax)
H: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
I: daxx (homo sapiens) (aka death domain associated protein)
J: rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens)) (aka histone deacetylase 2)
K: None of the above. | [I; J] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
C: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
D: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
E: daxx (drosophila melanogaster) (aka daxx-like protein)
F: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
G: daxx (xenopus tropicalis) (aka death-associated protein 6)
H: daxx (danio rerio) (aka death-domain associated protein)
I: histone deacetylase 7 (homo sapiens) (aka histone deacetylase 7)
J: rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens)) (aka histone deacetylase 2)
K: None of the above. | [A; J] |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx]
<Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
C: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
D: axed on x (drosophila melanogaster) (aka axed on x)
E: daxx (homo sapiens) (aka death domain associated protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdaxx]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: hyrax (drosophila melanogaster) (aka hyrax)
C: adx (homo sapiens) (aka ferredoxin 1)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: daxx (danio rerio) (aka death-domain associated protein)
F: None of the above. | [A] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin (oryctolagus cuniculus) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
D: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
E: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
F: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
G: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
H: homolog of separase (arabidopsis thaliana) (aka separase)
I: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
J: separase (candida albicans sc5314) (aka separase)
K: None of the above. | [D; C] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
B: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: separase (drosophila melanogaster) (aka separase)
E: homolog of separase (arabidopsis thaliana) (aka separase)
F: securin (xenopus laevis) (aka securin)
G: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
H: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
I: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
J: securin (saccharomyces cerevisiae s288c) (aka securin)
K: None of the above. | [G; A] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: separase (drosophila melanogaster) (aka separase)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
D: securin (xenopus laevis) (aka securin)
E: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
F: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
G: homolog of separase (arabidopsis thaliana) (aka separase)
H: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
I: separase (saccharomyces cerevisiae s288c) (aka separase)
J: None of the above. | [J; E] |
<Instruct>: Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
D: separase (candida albicans sc5314) (aka separase)
E: separase (saccharomyces cerevisiae s288c) (aka separase)
F: None of the above. | [B] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
E: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
F: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
G: separase (drosophila melanogaster) (aka separase)
H: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
I: separase (candida albicans sc5314) (aka separase)
J: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
K: None of the above. | [A; J] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
C: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
D: securin (xenopus laevis) (aka securin)
E: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
F: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
G: separase (drosophila melanogaster) (aka separase)
H: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
I: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
J: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
K: None of the above. | [A; B] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
D: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
E: separase (candida albicans sc5314) (aka separase)
F: None of the above. | [B] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: separase (drosophila melanogaster) (aka separase)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
E: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
F: None of the above. | [D] |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: separase (candida albicans sc5314) (aka separase)
E: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
F: None of the above. | [E] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
D: separase (saccharomyces cerevisiae s288c) (aka separase)
E: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
F: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
G: separase (drosophila melanogaster) (aka separase)
H: securin (saccharomyces cerevisiae s288c) (aka securin)
I: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
J: securin (xenopus laevis) (aka securin)
K: None of the above. | [C; F] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: securin (saccharomyces cerevisiae s288c) (aka securin)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separase (drosophila melanogaster) (aka separase)
D: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
E: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
F: securin (xenopus laevis) (aka securin)
G: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
H: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
I: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
J: None of the above. | [J; H] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
B: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: separase (drosophila melanogaster) (aka separase)
E: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
F: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
G: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
H: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
I: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
J: securin (saccharomyces cerevisiae s288c) (aka securin)
K: None of the above. | [F; B] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: securin (xenopus laevis) (aka securin)
C: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
D: securin (caenorhabditis elegans) (aka securin)
E: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
F: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
G: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
H: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
I: separase (candida albicans sc5314) (aka separase)
J: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
K: None of the above. | [G; A] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin (oryctolagus cuniculus) (aka securin)
C: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
D: separase (drosophila melanogaster) (aka separase)
E: securin (xenopus laevis) (aka securin)
F: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
G: securin (caenorhabditis elegans) (aka securin)
H: homolog of separase (arabidopsis thaliana) (aka separase)
I: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
J: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
K: None of the above. | [F; I] |
<Instruct>: Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin]
<Options>: A: securin (saccharomyces cerevisiae s288c) (aka securin)
B: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
C: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
D: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
E: securin (oryctolagus cuniculus) (aka securin)
F: None of the above. | [D] |
<Instruct>: Given the context 'A noncleavable separase mutant retains its ability to cleave cohesin in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
E: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
F: None of the above. | [C] |
<Instruct>: Given the context 'Our results suggest that separase is required for sister chromatid separation during mitosis in human cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
E: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
F: None of the above. | [E] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: securin (oryctolagus cuniculus) (aka securin)
B: securin (caenorhabditis elegans) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
D: homolog of separase (arabidopsis thaliana) (aka separase)
E: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
F: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
G: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
H: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
I: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
J: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
K: None of the above. | [E; G] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: securin (oryctolagus cuniculus) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
D: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
E: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
F: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
G: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
H: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
I: securin (xenopus laevis) (aka securin)
J: separase (drosophila melanogaster) (aka separase)
K: None of the above. | [C; A] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
B: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
E: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
F: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
G: separase (candida albicans sc5314) (aka separase)
H: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
I: securin (caenorhabditis elegans) (aka securin)
J: homolog of separase (arabidopsis thaliana) (aka separase)
K: None of the above. | [E; D] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin; separase]
<Options>: A: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
B: securin (caenorhabditis elegans) (aka securin)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
E: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
F: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
G: separase (candida albicans sc5314) (aka separase)
H: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
I: securin (xenopus laevis) (aka securin)
J: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
K: None of the above. | [J; D] |
<Instruct>: Given the context 'Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr gamma alternate reading frame protein)
B: cd3 gamma subunit of t-cell receptor complex (sus scrofa) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
D: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
E: cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens)) (aka cd3 gamma subunit of t-cell receptor complex)
F: None of the above. | [E] |
<Instruct>: Given the context 'We report here on the participation of CD3 gamma in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
D: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr gamma alternate reading frame protein)
E: cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens)) (aka cd3 gamma subunit of t-cell receptor complex)
F: None of the above. | [E] |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, including the TCR-CD3 itself, were either normal or only slightly affected.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
B: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
C: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
D: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
E: cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens)) (aka cd3 gamma subunit of t-cell receptor complex)
F: None of the above. | [E] |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, including the TCR-CD3 itself, were either normal or only slightly affected.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
B: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
C: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
D: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
E: None of the above. | [E] |
<Instruct>: Given the context 'In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [icam-1]
<Options>: A: intercellular adhesion molecule 1 (homo sapiens) (aka intercellular adhesion molecule 1)
B: icam4 (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
C: icam2 (homo sapiens) (aka intercellular adhesion molecule 2)
D: icam5 (homo sapiens) (aka intercellular adhesion molecule 5)
E: cell adhesion molecule 1 (homo sapiens) (aka cell adhesion molecule 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
D: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
E: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr gamma alternate reading frame protein)
F: None of the above. | [A] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: n-cam-l1 (homo sapiens) (aka l1 cell adhesion molecule)
B: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
C: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
D: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
E: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
F: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
G: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
H: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
I: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
J: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
K: None of the above. | [D; A] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
E: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
F: cyclin l1 (homo sapiens) (aka cyclin l1)
G: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
H: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
I: adam metallopeptidase domain 10 (homo sapiens) (aka adam metallopeptidase domain 10)
J: l1cam (homo sapiens) (aka l1 cell adhesion molecule)
K: None of the above. | [I; J] |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
E: cyclin l1 (homo sapiens) (aka cyclin l1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Release of L1 is enhanced by shedding inducers such as phorbol ester and pervanadate, but it is also enhanced by depletion of cellular cholesterol with methyl-beta-cyclodextrin (MCD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
D: cyclin l1 (homo sapiens) (aka cyclin l1)
E: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
F: None of the above. | [B] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
C: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
D: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
E: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
F: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
G: l1.1 (mus musculus) (aka skull morphology 1)
H: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
I: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
J: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
K: None of the above. | [B; A] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
B: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
E: l1.1 (mus musculus) (aka skull morphology 1)
F: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
G: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
H: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
I: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
J: None of the above. | [J; C] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
E: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
F: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
G: adam metallopeptidase domain 10 (homo sapiens) (aka adam metallopeptidase domain 10)
H: l1.1 (mus musculus) (aka skull morphology 1)
I: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
J: l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
K: None of the above. | [G; A] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1; adam10]
<Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
E: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
F: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
G: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
H: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
I: cyclin l1 (homo sapiens) (aka cyclin l1)
J: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
K: None of the above. | [C; G] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1; adam10]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: l1.1 (mus musculus) (aka skull morphology 1)
E: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
F: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
G: cyclin l1 (homo sapiens) (aka cyclin l1)
H: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
I: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
J: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
K: None of the above. | [A; J] |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: cyclin l1 (homo sapiens) (aka cyclin l1)
E: l1.1 (mus musculus) (aka skull morphology 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'L1-containing microvesicles could trigger haptotactic cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
E: cyclin l1 (homo sapiens) (aka cyclin l1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Only the neural L1 form carrying the RSLE signal for clathrin-dependent endocytosis was recruited and cleaved in vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
F: None of the above. | [E] |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: l1.1 (mus musculus) (aka skull morphology 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: l1.1 (mus musculus) (aka skull morphology 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1; adam10]
<Options>: A: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
E: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
F: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
G: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
H: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
I: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
J: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
K: None of the above. | [F; B] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1; adam10]
<Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
E: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
F: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
G: cyclin l1 (homo sapiens) (aka cyclin l1)
H: l1.1 (mus musculus) (aka skull morphology 1)
I: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
J: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
K: None of the above. | [C; B] |
<Instruct>: Given the context 'The findings establish a novel role for ADAM10 as a vesicle-based protease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10]
<Options>: A: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
B: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
D: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
E: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
F: None of the above. | [C] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: yaf1 (homo sapiens) (aka histone deacetylase 2)
B: yaf2 (bos taurus) (aka yy1 associated factor 2)
C: yaf2 (homo sapiens) (aka yy1 associated factor 2)
D: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
E: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
F: yaf2 (xenopus laevis) (aka yy1 associated factor 2 s homeolog)
G: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
H: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
I: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
J: yaf2 (sus scrofa) (aka yy1 associated factor 2)
K: None of the above. | [C; H] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
D: yaf2 (bos taurus) (aka yy1 associated factor 2)
E: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
F: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
G: yaf2 (xenopus tropicalis) (aka yy1 associated factor 2)
H: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
I: yaf2 (homo sapiens) (aka yy1 associated factor 2)
J: yaf1 (homo sapiens) (aka histone deacetylase 2)
K: None of the above. | [I; E] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myc; mycn; mycl]
<Options>: A: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
B: mycl (mus musculus) (aka v-myc avian myelocytomatosis viral oncogene lung carcinoma derived)
C: mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis) (aka mycn proto-oncogene, bhlh transcription factor)
D: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
E: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
F: mycn (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
G: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
H: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
I: mycs-like (mus musculus) (aka cdna sequence, aa543401)
J: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
K: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
L: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
M: l-myc (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
N: mycl2 (homo sapiens) (aka mycl pseudogene 1)
O: None of the above. | [K; D; M] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myc; mycn; mycl]
<Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
C: mycn proto-oncogene, bhlh transcription factor (rattus norvegicus) (aka mycn proto-oncogene, bhlh transcription factor)
D: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
E: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
F: mycl (mus musculus) (aka v-myc avian myelocytomatosis viral oncogene lung carcinoma derived)
G: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
H: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
I: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
J: mycs-like (mus musculus) (aka cdna sequence, aa543401)
K: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
L: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
M: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
N: None of the above. | [D; G; I] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myc; mycn; mycl]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: l-myc (mus musculus) (aka v-myc avian myelocytomatosis viral oncogene lung carcinoma derived)
C: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
D: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
E: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
F: n-myc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
G: mycl2 (homo sapiens) (aka mycl pseudogene 1)
H: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
I: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
J: mycs-like (mus musculus) (aka cdna sequence, aa543401)
K: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
L: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
M: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
N: None of the above. | [D; F; A] |
<Instruct>: Given the context 'The Myc protein is the best studied member of this family and is involved in cell cycle regulation, differentiation and cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myc]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
D: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
E: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
F: None of the above. | [D] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; mycn]
<Options>: A: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
B: yaf2 (bos taurus) (aka yy1 associated factor 2)
C: n-myc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
D: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
E: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
F: yaf1 (saccharomyces cerevisiae s288c) (aka oleate-activated transcription factor oaf1)
G: yaf2-a (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis)) (aka yy1 associated factor 2 s homeolog)
H: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
I: yaf2 (homo sapiens) (aka yy1 associated factor 2)
J: mycn (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
K: None of the above. | [I; C] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; mycn]
<Options>: A: yaf1 (saccharomyces cerevisiae s288c) (aka oleate-activated transcription factor oaf1)
B: yaf2 (bos taurus) (aka yy1 associated factor 2)
C: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
D: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
E: mycn (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
F: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
G: mycn (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
H: yaf2-a (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis)) (aka yy1 associated factor 2 s homeolog)
I: yaf2 (homo sapiens) (aka yy1 associated factor 2)
J: mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis) (aka mycn proto-oncogene, bhlh transcription factor)
K: None of the above. | [I; E] |
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