instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: c-fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
B: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
C: il22 (homo sapiens) (aka interleukin 22)
D: fos like 1, ap-1 transcription factor subunit (homo sapiens) (aka... | [A; K; M] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcrip... | [K; O; D] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
B: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
C: jun proto-oncogene (mus mu... | [F; I; O] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: il-2 (homo sapiens) (aka interleukin 2)
D: jun proto-oncogene... | [A; I; C] |
<Instruct>: Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [c-fos]
<Options>: A: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
B: c-fos (xenopus tropicalis) (aka fbj murine osteosarcoma viral oncogene homolog)
C: fos like 1, ap-1 transcription factor subunit (homo sapiens) (aka fos... | [E] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: cd2 (bos taurus) (aka cd2 molecule)
B: cd228 (homo sapiens) (aka melanotransferrin)
C: csf2 (homo sapiens) (aka colony stimulating factor 2)
D: il-2 (homo sapiens) (aka interleukin 2)
E: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2... | [I; D] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd2 (gallus gallus) (aka cd2 molecule)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: interleukin 2 (homo sapiens) (aka interleukin 2)
F: colony stimulating factor 2 (homo sapiens) (ak... | [J; E] |
<Instruct>: Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [cd2]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: cd228 (homo sapiens) (aka melanotransferrin)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: cd2 molecule (bos taurus) (aka cd2 molecule)
F: None of the above. | [A] |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd21 (homo sapiens) (aka complement c3d receptor 2)
B: cd2 molecule (bos taurus) (aka cd2 molecule)
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: cd2 molecule (homo sapiens) (aka cd2 molecule)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: None of the a... | [D] |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd228 (homo sapiens) (aka melanotransferrin)
D: cd2 molecule (bos taurus) (aka cd2 molecule)
E: None of the above. | [E] |
<Instruct>: Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: cd2 molecule (bos taurus) (aka cd2 molecule)
C: cd2 (homo sapiens) (aka cd2 molecule)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: None of the above. | [C] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
B: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
C: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
D: mtor (mus musc... | [H; H] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
B: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
C: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
D: targ... | [H; H] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: alpha kinase 1 (homo sapiens) (aka alpha kinase 1)
B: ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 2 (homo sapiens)) (aka protein kinase amp-activated catalytic subunit alpha 2)
C: protein kinase camp-activated catalytic subunit alpha (ho... | [K; K] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: prkaa1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
B: ampka1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
C: alpha kinase 1 (homo sapiens) (aka alpha kinase 1)
D: prkaca (homo sapiens) (protein kinase cam... | [K; K] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: ribosomal protein s6 kinase a6 (homo sapiens) (aka ribosomal protein s6 kinase a6)
B: torc1 (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
C: ribosoma... | [L; L; L] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: mechanistic target of rapamycin (drosophila melanogaster) (aka mechanistic target of rapamycin)
B: tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
... | [M; M; M] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: p70-s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
B: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
C: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
D: mtor (drosophila melanogaster) (mega... | [N; N; N] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eif4ep1 (homo sapiens) (aka eukaryotic translation initiation factor 4e pseudogene 1)
B: eukaryotic translation initiation factor 4e (xenopus tropicalis) (aka eukaryotic translation initiation factor 4e)
C: eif4f (homo sapiens) (eukaryotic translation initiation factor 4 gamma 1... | [K; K] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eif4c (homo sapiens) (aka eukaryotic translation initiation factor 1a x-linked)
B: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
C: eif4e (xenopus tropicalis) (eukaryotic translation initiation factor 4e (xenopus tro... | [K; K] |
<Instruct>: Given the context 'In contrast, eIF2B activity remained unchanged in response to AICAR treatment and therefore would not appear to contribute to the depression in protein synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [eif2b]
<Options>: A: eukaryotic translation initiation factor 2b subunit beta (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit beta)
B: eif2beta (homo sapiens) (aka eukaryotic translation initiation factor 2 subunit beta)
C: eif2b (drosophila melanogaster) (eukaryotic translation ini... | [E] |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: protocadherin 12 (homo sapiens) (aka protocadherin 12)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
E: pcdhg (homo sapiens) (aka protocadheri... | [F] |
<Instruct>: Given the context 'The gene was predominantly expressed in liver, kidney and colon tissues, and was thus designated Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
D: protocadherin 1 (homo sapiens) (aka protocadherin 1)
E: protocadherin 12 (homo sapiens) (aka protoca... | [F] |
<Instruct>: Given the context 'The expression of Protocadherin LKC is markedly reduced in cancers arising from these tissues at both transcriptional and protein levels.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: protocadherin 10 (homo sapiens) (aka protocadherin 10)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: pcdhac (homo sapiens) (aka protocadherin... | [F] |
<Instruct>: Given the context 'To investigate the effects of Protocadherin LKC expression in colon cancer, we introduced the gene into colon cancer cell line HCT116, which does not express this gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: pcdhg (homo sapiens) (aka protoca... | [F] |
<Instruct>: Given the context 'Significantly, Protocadherin LKC expression induced contact inhibition of cell proliferation although it did not affect growth rate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: protocadherin 1 (homo sapiens) (aka protocadherin 1)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: pcdh7 (homo sapiens) (aka protocadherin 7)... | [F] |
<Instruct>: Given the context 'When grown to post-confluence in monolayer cells cultures, Protocadherin LKC-expressing HCT116 no longer formed multiple cell layers and showed the typical paving stone morphology of normal epithelial cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
E: protocadherin 12 (homo sapiens) (aka p... | [F] |
<Instruct>: Given the context 'Furthermore, expression of Protocadherin LKC suppressed tumor formation of HCT116 cells in a nude mouse model.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: protocadherin 12 (homo sapiens) (aka protocadherin 12)
B: protocadherin 1 (homo sapiens) (aka protocadherin 1)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhac (homo sapiens) (aka protocadherin alpha constant)
E: pcdhgc3 (homo sapiens) (aka protocadherin ... | [F] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: mast205 (drosophila melanogaster) (aka drop out)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: 205-kda map (drosophila melanogaster) (aka microtubule-associated protein 205)
D: transmembrane ... | [M; M; N] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: pcdhac (homo sapiens) (aka protocadherin alpha constant)
B: ygr205w (saccharomyces cerevisiae s288c) (aka putative atp-dependent kinase)
C: mast205 (homo sapiens) (aka microtubule associated serine/threonine ... | [C; C; O] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: protocadherin 12 (homo sapiens) (aka protocadherin 12)
B: mast205 (drosophila melanogaster) (aka drop out)
C: tmem205 (homo sapiens) (aka transmembrane protein 205)
D: ygr205w (saccharomyces cerevisiae s288c)... | [J; J; N] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: protocadherin 10 (homo sapiens) (aka protocadherin 10)
D: protocadherin 12 (homo sapiens) (aka protocadherin 12)
E: protocadherin 1 (homo sapiens) (a... | [F] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: pdz73 (homo sapiens) (aka ush1 protein network component harmonin)
B: pdzd1 (homo sapiens) (aka pdz domain containing 1)
C: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: pdz domain c... | [K; K] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: pcdhac (homo sapiens) (aka protocadherin alpha constant)
B: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
C: pdz domain containing 1 (homo sapiens) (aka pdz domain containing 1)
D: pdzx (homo sapiens) (aka magi family member, x-linked)
E: pdz domain co... | [K; K] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
B: daxx (mus musculus) (aka fas death domain-associated protein)
C: histone deacetylase 2 (homo sapiens) (aka histone deacetylase 2)
D: dek proto-oncogene (mu... | [K; C; N] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
C: daxx (xenopus tropicalis) (aka death-associated protein 6)
D: dek (homo sapiens) (aka dek proto-oncogen... | [J; N; D] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: dee (homo sapiens) (aka klk3 upstream enhancer/promoter region)
B: hdac2 (homo sapiens) (aka histone deacetylase 2)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: dek (xenopus tropicalis) (aka dek proto-oncogene)
E:... | [L; B; O] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: dek proto-oncogene (homo sapiens) (aka dek proto-oncogene)
B: dax1 (homo sapiens) (aka nuclear receptor subfamily 0 group b member 1)
C: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
D: dek (xenopus tropicalis... | [F; M; A] |
<Instruct>: Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [daxx]
<Options>: A: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
B: daxx (mus musculus) (aka fas death domain-associated protein)
C: dax1 (homo sapiens) (aka nuclear receptor subfamily 0 group b member 1)
D: daxx (homo sapiens) (aka death domain associated protein)
E: daxx (danio rerio... | [D] |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [hdaxx]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: adx (homo sapiens) (aka ferredoxin 1)
D: daxx (danio rerio) (aka death-domain associated protein)
E: daxx (homo sapiens) (aka death domain ass... | [E] |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept for each me... | <Mentions>: [hdaxx]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: hyrax (drosophila melanogaster) (aka hyrax)
C: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
D: axed on x (drosophila melanogaster) (aka axed on x)
E: adx (homo sapiens) (aka ferredoxin 1)... | [A] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: hdac2 (homo sapiens) (aka histone deacetylase 2)
C: histone deacetylase 9 (homo sapiens) (aka histone deacetylase 9)
D: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
E: daxx (homo sapiens) (aka death do... | [E; B] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: daxx (homo sapiens) (aka death domain associated protein)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
E: histone deacetylase 2 (xenopus tropic... | [B; I] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (drosophila melanogaster) (aka daxx-like protein)
B: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
C: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
D: hdac2 (homo sapiens) (aka histone deacetylase 2)
E... | [J; D] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: histone deacetylase 2 (xenopus tropicalis) (aka histone deacetylase 2)
D: histone deacetylase 9 (homo sapiens) (aka histone deacetylas... | [I; J] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
C: histone deacetylase 10 (homo sapiens) (aka histone deacetylase 10)
D: histone deacetylase 2 (xenopus tropicalis) (aka histone deacety... | [A; J] |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [hdaxx]
<Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: daxx.l (xenopus laevis) (aka death-associated protein 6 l homeolog)
C: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
D: axed on x (drosophila melanogaster) (aka axed on x)
E: daxx (homo s... | [E] |
<Instruct>: Given the context 'A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [hdaxx]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: hyrax (drosophila melanogaster) (aka hyrax)
C: adx (homo sapiens) (aka ferredoxin 1)
D: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
E: daxx (danio rerio) (aka death-domain associated protein)
F: None of ... | [A] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin (oryctolagus cuniculus) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulato... | [D; C] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
B: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)... | [G; A] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: separase (drosophila melanogaster) (aka separase)
B: securin (saccharomyces cerevisiae s288c) (aka securin)
C: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
D: securin (xenopus laev... | [J; E] |
<Instruct>: Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [separase]
<Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies lik... | [B] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
C: separase (saccharomyces cerevi... | [A; J] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
C: extra spindle pole bodies 1,... | [A; B] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies 1, separase (mus musculus) (aka... | [B] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: separase (drosophila melanogaster) (aka separase)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1, separa... | [D] |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
C: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
... | [E] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of s... | [C; F] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [securin; separase]
<Options>: A: securin (saccharomyces cerevisiae s288c) (aka securin)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separase (drosophila melanogaster) (aka separase)
D: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
E: provisional ortholog of p... | [J; H] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
B: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
C: separin homolog sep-1 (cae... | [F; B] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: securin (xenopus laevis) (aka securin)
C: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
D: securin (caenorhabditi... | [G; A] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [securin; separase]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: securin (oryctolagus cuniculus) (aka securin)
C: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bo... | [F; I] |
<Instruct>: Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin]
<Options>: A: securin (saccharomyces cerevisiae s288c) (aka securin)
B: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
C: sec62 homolog, preprotein translocat... | [D] |
<Instruct>: Given the context 'A noncleavable separase mutant retains its ability to cleave cohesin in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: extra spindle... | [C] |
<Instruct>: Given the context 'Our results suggest that separase is required for sister chromatid separation during mitosis in human cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D... | [E] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [securin; separase]
<Options>: A: securin (oryctolagus cuniculus) (aka securin)
B: securin (caenorhabditis elegans) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
D: homolog of separase (arabidopsis thaliana... | [E; G] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: securin (oryctolagus cuniculus) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid sep... | [C; A] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [securin; separase]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
B: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regu... | [E; D] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [securin; separase]
<Options>: A: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
B: securin (caenorhabditis elegans) (aka securin)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: esp1 (homo sapiens) (e... | [J; D] |
<Instruct>: Given the context 'Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr gamma alternate reading frame protein)
B: cd3 gamma subunit of t-cell receptor complex (sus scrofa) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3 gamma subunit of t-cell receptor com... | [E] |
<Instruct>: Given the context 'We report here on the participation of CD3 gamma in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [cd3 gamma]
<Options>: A: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit ... | [E] |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, includin... | <Mentions>: [cd3 gamma]
<Options>: A: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
B: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
C: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
D: in... | [E] |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, includin... | <Mentions>: [cd3 gamma]
<Options>: A: cd3 antigen, gamma polypeptide (mus musculus) (aka cd3 antigen, gamma polypeptide)
B: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
C: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell recepto... | [E] |
<Instruct>: Given the context 'In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [icam-1]
<Options>: A: intercellular adhesion molecule 1 (homo sapiens) (aka intercellular adhesion molecule 1)
B: icam4 (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
C: icam2 (homo sapiens) (aka intercellular adhesion molecule 2)
D: icam5 (homo sapiens) (aka interc... | [A] |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [cd3 gamma]
<Options>: A: cd3-gammaamma (homo sapiens) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
D: cd3 a... | [A] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: n-cam-l1 (homo sapiens) (aka l1 cell adhesion molecule)
B: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
C: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
D: adam10 (homo sapiens... | [D; A] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: adam15 (homo sapiens) (aka ada... | [I; J] |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [l1]
<Options>: A: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
D: l1 cell adhes... | [D] |
<Instruct>: Given the context 'Release of L1 is enhanced by shedding inducers such as phorbol ester and pervanadate, but it is also enhanced by depletion of cellular cholesterol with methyl-beta-cyclodextrin (MCD).', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
D: cyclin l1 (homo sapiens) (aka cyclin ... | [B] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: adam10 (homo sapiens) (aka adam metallopeptidase domain 10)
C: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
D: disintegrin and metalloproteinase domain-containing ... | [B; A] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
B: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: adam15 (homo sapiens) (aka adam metallopeptidase dom... | [J; C] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: adam9 (homo sapiens) (aka... | [G; A] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [l1; adam10]
<Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: metalloproteinase... | [C; G] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [l1; adam10]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: l1.1 (mus musculus) (aka skull morphology 1)
E: disint... | [A; J] |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: cyclin l1 (homo sapiens) (aka cyclin l1)
... | [B] |
<Instruct>: Given the context 'L1-containing microvesicles could trigger haptotactic cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhes... | [C] |
<Instruct>: Given the context 'Only the neural L1 form carrying the RSLE signal for clathrin-dependent endocytosis was recruited and cleaved in vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g pro... | [E] |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: adhesion g protein-coupled rece... | [C] |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
B: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: l1.1 ... | [E] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Mentions>: [l1; adam10]
<Options>: A: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesi... | [F; B] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Mentions>: [l1; adam10]
<Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10... | [C; B] |
<Instruct>: Given the context 'The findings establish a novel role for ADAM10 as a vesicle-based protease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10]
<Options>: A: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
B: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
D: metalloproteinase adam10-like (xenopus tropicalis... | [C] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: yaf1 (homo sapiens) (aka histone deacetylase 2)
B: yaf2 (bos taurus) (aka yy1 associated factor 2)
C: yaf2 (homo sapiens) (aka yy1 associated factor 2)
D: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
E: myc (mus musculus) (myelocytomatosis oncogen... | [C; H] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
D: yaf2 (b... | [I; E] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
B: mycl (mus musculus) (aka v-myc avian myelocytomatosis viral oncogene lung carcinoma derived)
C: mycn proto-oncogene, bhlh transcription factor (xenopus tropica... | [K; D; M] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
C: mycn proto-oncogene, bhlh transcription factor (rattus norvegicus) (aka mycn proto-oncogene, bhlh transcription ... | [D; G; I] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: l-myc (mus musculus) (aka v-myc avian myelocytomatosis viral oncogene lung carcinoma derived)
C: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
D: myc (homo sapiens) (aka myc proto-o... | [D; F; A] |
<Instruct>: Given the context 'The Myc protein is the best studied member of this family and is involved in cell cycle regulation, differentiation and cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [myc]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral... | [D] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [yaf2; mycn]
<Options>: A: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
B: yaf2 (bos taurus) (aka yy1 associated factor 2)
C: n-myc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
D: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene... | [I; C] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [yaf2; mycn]
<Options>: A: yaf1 (saccharomyces cerevisiae s288c) (aka oleate-activated transcription factor oaf1)
B: yaf2 (bos taurus) (aka yy1 associated factor 2)
C: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene n... | [I; E] |
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