instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Here, we examined the effect of alpha(2) agonists on a clone of Caco2 cells expressing the human alpha(2A) adrenoceptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha(2a) adrenoceptor]
<Options>: A: alpha2bar (homo sapiens) (aka adrenoceptor alpha 2b)
B: alpha2car (homo sapiens) (aka adrenoceptor alpha 2c)
C: adrenoceptor alpha 1b (homo sapiens) (aka adrenoceptor alpha 1b)
D: adra2 (homo sapiens) (aka adrenoceptor alpha 2a)
E: None of the above. | [D] |
<Instruct>: Given the context 'Cells were transfected with a bicistronic plasmid containing the alpha2C10 and neomycin phosphotransferase genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha2c10]
<Options>: A: pcdh-alpha10 (homo sapiens) (aka protocadherin alpha 10)
B: adrenoceptor alpha 2c (homo sapiens) (aka adrenoceptor alpha 2c)
C: alpha2aar (homo sapiens) (aka adrenoceptor alpha 2a)
D: cholinergic receptor nicotinic alpha 10 subunit (homo sapiens) (aka cholinergic receptor nicotinic... | [C] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk6 (homo sapiens) (aka mitogen-activated protein kinase 12)
B: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
C: sapk2 (homo sapiens) (aka mitogen-activated protein kinase 11)
D: erk1 (homo sapiens) (aka mitogen-activated p... | [D; D; E] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk6 (homo sapiens) (aka mitogen-activated protein kinase 12)
B: erk2 (mus musculus) (aka mitogen-activated protein kinase 1)
C: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
D: sapk2 (homo sapiens) (aka mitogen-activated pr... | [I; I; E] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: mitogen-activated protein kinase 1 (homo sapiens) (aka mitogen-activated protein kinase 1)
B: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
C: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
D: erk2 (mus musculu... | [B; B; I] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk8 (homo sapiens) (aka mitogen-activated protein kinase 15)
B: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
C: mitogen-activated protein kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
D: er... | [B; B; D] |
<Instruct>: Given the context 'It was unaffected by protein kinase C downregulation but correlated with a transient increase in Shc tyrosine phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [shc]
<Options>: A: shc3 (homo sapiens) (aka shc adaptor protein 3)
B: shc (homo sapiens) (aka shc adaptor protein 1)
C: shc adaptor protein 2 (homo sapiens) (aka shc adaptor protein 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemoki... | [J; S; P; P] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: il-4 (homo sapiens) (aka interleukin 4)
B: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
C: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
D: interleukin 1 family member 10 (homo sapiens) (aka int... | [A; M; N; N] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
D: ifitm10 (... | [Q; G; P; P] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: ifi-30 (homo sapiens) (aka ifi30 lysosomal thiol reductase)
B: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
C: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
D: il4 (homo sapiens) (aka in... | [D; E; M; M] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
B: ik cytokine (homo sapiens) (aka ik cytokine)
C: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
D: mip-1d (homo sapiens) (aka c-c moti... | [I; I; A; A] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
B: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
C: ld78gamma (homo sapiens) (aka c-c motif chemokine ligand 3 pseudogene 1)
D: mi... | [I; I; P; P] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
C: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
D: mig (mus musculus) ... | [C; C; Q; Q] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: ifi78 (homo sapiens) (aka mx dynamin like gtpase 1)
B: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
C: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
D: tac1 (homo sapiens) (aka tachy... | [B; B; C; C] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [cxcr3 receptor]
<Options>: A: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
C: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
D: chemokine (c-c motif) receptor 3 ... | [A] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely th... | <Mentions>: [cxcr3 receptor]
<Options>: A: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
B: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
C: cxcr3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
D: chemokine (c-c motif) receptor 3 (xenopus tropicalis) ... | [E] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: il10 (homo sapiens) (aka interleukin 10)
C: il-17 (bos taurus) (aka interleukin 17a)
D: interleukin 5 (homo sapiens) (aka interleukin 5)
E: interferon alpha 10 (homo sapiens) (aka ... | [P; B; O; Q] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: interleukin 17f (homo sapiens) (aka interleukin 17f)
B: interleukin 10 (homo sapiens) (aka interleukin 10)
C: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
D: il4 (bos taurus) (aka interleukin 4)
E: il17a (homo sapiens) (interleukin 17a (homo sapiens... | [P; B; E; I] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: interleukin 5 (homo sapiens) (aka interleukin 5)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: interleukin 10 (bos taurus) (aka interleukin 10)
D: interleukin 17c (homo sapiens) (aka interleukin 17c)
E: bolf1 (human gammaherpesvirus 4) (aka tegument ... | [I; L; K; J] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: il4 (bos taurus) (aka interleukin 4)
C: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
D: interleukin 10 (homo sapiens) (aka interleukin 10)
E: il-17 (bos taurus) (aka interleukin 17a)
F: inte... | [H; D; R; P] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
B: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
C: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
D: taci (homo sapiens) (aka tnf receptor superfamily member... | [I; C; N] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
C: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: i-tac (mus musculus) (aka chemoki... | [F; J; C] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mentio... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
E: mig... | [A; F; O] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interferon gamma (homo sapiens) (aka interferon gamma)
B: interleukin 17f (homo sapiens) (aka interleukin 17f)
C: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
D: il17a (homo sapiens) (interleukin 17a (homo sapiens)) (aka interleukin 17a)
E: cd... | [S; P; D; A] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
B: interleukin 10 (bos taurus) (aka interleukin 10)
C: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
D: il-17 (bos taurus) (aka interleukin 17a)
E: interleukin 5 (homo sapiens) (aka interleukin ... | [K; S; H; R] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
B: il-17 (bos taurus) (aka interleukin 17a)
C: interleukin 10 (oryctolagus cuniculus) (aka interleukin 10)
D: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
E: interleukin 4 (bos taurus) (aka ... | [N; P; K; I] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: interferon gamma (xenopus tropicalis) (aka interferon gamma)
B: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: interferon gamma (sus scrofa) (aka interferon gamma)
E: il-17 (bos taur... | [P; N; R; H] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
C: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
D: il-10c (homo sapiens) (aka interleukin 19)
E: rantes (homo sapiens) (aka c-c mo... | [P; O; R; K] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
D: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
E: lymphotoxin alph... | [S; B; J; I] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
B: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: rantes (homo sapiens) (aka c-c motif ... | [F; R; K; Q] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [tnf-alpha; ip-10; mig; i-tac]
<Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: transforming growth factor alpha (homo sapiens) (aka transforming growth factor alpha)
C: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
D: rantes (homo sapiens) (aka... | [R; O; J; S] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [ip-10; mig]
<Options>: A: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
D: interleukin 10 (homo sapiens) (aka interleukin 10)
E: interleukin 1 family member 10 (homo sap... | [A; I] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [ip-10; mig]
<Options>: A: interleukin 10 (homo sapiens) (aka interleukin 10)
B: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
E: interleukin 1 family member 10 (homo sapiens) ... | [H; D] |
<Instruct>: Given the context 'Immunohistochemistry of skin affected by ACD revealed that >70% of infiltrating cells were reactive for CXCR3 and that CXCR3 staining colocalized in CD4+ and CD8+ T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [cxcr3]
<Options>: A: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
C: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)... | [A] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: interferon gamma (xenopus tropicalis) (aka interferon gamma)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
D: il-4 (homo sapiens) (aka interleukin 4)
E: interferon gamma (sus scrofa) (aka inte... | [J; D; K] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: interferon gamma (homo sapiens) (aka interferon gamma)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
D: ifn-gamma (gallus gallus) (aka interferon)
E: cc-ckr-9 (... | [A; J; H] |
<Instruct>: Given the context 'Nickel-specific CD4+ and CD8+ T cell lines established from ACD skin produced IFN-gamma and IL-4 and expressed moderate to high levels of CXCR3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ifn-gamma; il-4; cxcr3]
<Options>: A: interferon gamma (sus scrofa) (aka interferon gamma)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: interferon gamma (mus musculus) (aka interferon gamma)
E: il4 (bos taurus) (aka interleukin... | [O; K; C] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: interferon gamma (gallus gallus) (aka interferon gamma)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x-c motif chemokine r... | [D; H; G] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: il-4 (homo sapiens) (aka interleukin 4)
B: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
C: ifn-gamma (gallus gallus) (aka interferon)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c m... | [D; O; A] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: il-4 (bos taurus) (aka interleukin 4)
C: interferon gamma (mus musculus) (aka interferon gamma)
D: ifn-gamma (gallus gallus) (aka interferon)
E: c-x-c motif chemokine receptor 3... | [N; J; G] |
<Instruct>: Given the context 'Finally, CXCR3 agonistic chemokines released by stimulated keratinocytes triggered calcium mobilization in skin-derived nickel-specific CD4+ T cells and promoted their migration, with supernatant from keratinocyte cultures stimulated with IFN-gamma and IL-4 attracting more efficaciously t... | <Mentions>: [cxcr3; ifn-gamma; il-4]
<Options>: A: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
B: interferon gamma (homo sapiens) (aka interferon gamma)
C: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
D: il-4 (bos taurus) (aka interleukin 4)
E: interferon gamma (mus musculus) (aka interf... | [G; B; O] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
B: interferon gamma (homo sapiens) (aka interferon gamma)
C: interferon gamma (gallus gallus) (aka interferon gamma)
D: tnf (homo sapiens) (aka tumor necrosis factor)
E: bllf1 (human gammaherpesvirus 4... | [H; B; D; S] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: ifn-alpha (homo sapiens) (aka interferon alpha 1)
B: ifn-gamma (gallus gallus) (aka interferon)
C: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
D: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
E: interferon alpha 10 (homo sapiens) ... | [T; J; O; R] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
B: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: interleukin 4 (homo sapiens) (aka interleukin 4)
D: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member ... | [C; O; S; B] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [il-4; ifn-gamma; tnf-alpha; ip-10]
<Options>: A: interferon gamma (sus scrofa) (aka interferon gamma)
B: tnf-a (xenopus tropicalis) (aka tumor necrosis factor)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: il4 (homo sapiens) (aka interleukin 4)
E: il-10c (homo sapiens) (aka interleukin 19)
F: bolf... | [D; P; G; I] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
C: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
D: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1... | [A; F; H] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
B: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
C: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
D: mig1 (homo sapiens) (aka vacuolar protei... | [C; F; N] |
<Instruct>: Given the context 'In conclusion, IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.', select the correct biomedical co... | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
B: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
C: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine re... | [A; B; C] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [graf; mll]
<Options>: A: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
B: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
C: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
D: graf2 ... | [A; J] |
<Instruct>: Given the context 'The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [graf; mll]
<Options>: A: grap (homo sapiens) (aka grb2 related adaptor protein)
B: mllt7 (homo sapiens) (aka forkhead box o4)
C: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
D: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
E: mll (ho... | [J; E] |
<Instruct>: Given the context 'We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf (homo sapiens) (aka rho gtpase activating protein 26)
B: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
C: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
D: graf-1ef (xenopus tropicalis) (aka eukaryotic transla... | [A] |
<Instruct>: Given the context 'We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: grf1 (homo sapiens) (aka ras protein specific guanine n... | [E] |
<Instruct>: Given the context 'This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [mll]
<Options>: A: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
B: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
C: mllt2-like (homo sapiens) (aka alf transcription elongation fac... | [D] |
<Instruct>: Given the context 'GRAF encodes a member of the Rho family of the GTPase-activating protein (GAP) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
B: graf1 (homo sapiens) (aka rho gtpase activating protein 26)
C: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
D: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releas... | [B] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [graf; rhoa]
<Options>: A: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
B: rhoa-a (xenopus laevis) (ras homolog gene family, member a, gene 2 s homeolog (xenopus laevis)) (aka ras homolog gene family, member a, gene 2 s homeolog)
C: ras homolog family member a (xenopus tropicalis) (aka ras ho... | [K; K] |
<Instruct>: Given the context 'On the protein level, it is 90% homologous to the recently described chicken GRAF gene that functions as a GAP of RhoA in vivo and is thus a critical component of the integrin signaling transduction pathway.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [graf; rhoa]
<Options>: A: grap (homo sapiens) (aka grb2 related adaptor protein)
B: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
C: rhoa-a (xenopus laevis) (ras homolog family member a s homeolog (xenopus laevis)) (aka ras homolog family member a s homeolog)
D: graf2... | [K; K] |
<Instruct>: Given the context 'The particular position of the human GRAF gene at 5q31 and the proposed antiproliferative and tumor suppressor properties of its avian homologue suggest that it also might be pathogenetically relevant for hematologic malignancies with deletions of 5q.', select the correct biomedical conce... | <Mentions>: [graf]
<Options>: A: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
B: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
C: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
D: graf (homo sapiens) (aka rho gtpase activating protein 26)
E: graf2... | [D] |
<Instruct>: Given the context 'To investigate this possibility, we sequenced 4-5 individual cDNA clones from 13 cases in which one allele of GRAF was deleted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [graf]
<Options>: A: graf (homo sapiens) (aka rho gtpase activating protein 26)
B: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
C: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
D: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
E: graf3... | [A] |
<Instruct>: Given the context 'We found point mutations within the GAP domain of the second GRAF allele in one patient.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
B: grap (homo sapiens) (aka grb2 related adaptor protein)
C: graf1 (xenopus tropicalis) (aka rho gtpase activating protein 26)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
E: graf (homo sa... | [E] |
<Instruct>: Given the context 'In two additional patients we found an insertion of 52 or 74 bp within the GRAF cDNA that generates a reading frame shift followed by a premature stop codon.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [graf]
<Options>: A: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
B: graf (homo sapiens) (aka rho gtpase activating protein 26)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
E: graf-1ef (homo s... | [B] |
<Instruct>: Given the context 'In two additional patients we found an insertion of 52 or 74 bp within the GRAF cDNA that generates a reading frame shift followed by a premature stop codon.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [graf]
<Options>: A: grap (homo sapiens) (aka grb2 related adaptor protein)
B: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
C: grf1 (homo sapiens) (aka ras protein specific guanine nucleotide releasing factor 1)
D: graf2 (homo sapiens) (aka rho gtpase activating protein 1... | [E] |
<Instruct>: Given the context 'GRAF maps outside the previously defined commonly deleted 5q31 region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [graf]
<Options>: A: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf (homo sapiens) (aka rho gtpase activating protein 26)
C: grap (homo sapiens) (aka grb2 related adaptor protein)
D: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha... | [B] |
<Instruct>: Given the context 'Nevertheless, inactivation of both alleles in at least some cases suggests that deletions and mutations of the GRAF gene may be instrumental in the development and progression of hematopoeitic disorders with a del(5q).', select the correct biomedical concept for each mention using the pro... | <Mentions>: [graf]
<Options>: A: graf-1ef (homo sapiens) (aka eukaryotic translation elongation factor 1 alpha 1)
B: graf2 (homo sapiens) (aka rho gtpase activating protein 10)
C: graf3 (homo sapiens) (aka rho gtpase activating protein 42)
D: graf-1ef (xenopus tropicalis) (aka eukaryotic translation elongation factor 1... | [E] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: c-c motif chemokine ligand 13 (homo sapiens) (aka c-c motif chemokine ligand 13)
B: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
C: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
D: ccr-8 (homo... | [M; Q; D; M] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
B: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
C: ccr-6 (homo sapiens) (aka c-c motif chemokine rece... | [P; G; H; P] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
C: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
D: cmkbr8 (homo sapiens) (aka c-c motif chem... | [S; L; D; S] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: crfr-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
B: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
C: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
D: lec (homo sapiens) (aka c-c motif chemokine lig... | [D; O; J; D] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; ccr1; ccr8; liver-expressed chemokine]
<Options>: A: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
B: c-c motif chemokine 21-like (xenopus tropicalis) (aka c-c motif chemokine 21-like)
C: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: cc-ckr-9 (homo sapiens) (aka c-c m... | [E; M; S; E] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec1 (drosophila melanogaster) (aka parched)
B: scya4 (homo sapiens) (aka c-c motif chemokine ligand 4)
C: mclc (xenopus tropicalis) (aka chloride channel clic-like 1)
D: hccs-4 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 20)
E: lec3 (homo sapien... | [P; P; P; P] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: ncc-4 (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
B: lcc (mus musculus) (aka sry (sex determining region y)-box 2)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
E:... | [L; L; L; L] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec1 (drosophila melanogaster) (aka parched)
B: scya4 (homo sapiens) (aka c-c motif chemokine ligand 4)
C: lce (homo sapiens) (aka elovl fatty acid elongase 6)
D: lmnc (homo sapiens) (aka lamin a/c)
E: c-c motif chemokine 4 homolog (xenopus tropicalis) (aka c-c motif c... | [G; G; G; G] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: lec1 (drosophila melanogaster) (aka parched)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: mcp-4 (homo sapiens) (aka c-c motif chemokine ligand 13)
D: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
E: scya4 (homo sapiens) (aka c-c motif chem... | [Q; Q; Q; Q] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [lec; lmc; hcc-4; ncc-4]
<Options>: A: ncc-1 (homo sapiens) (aka c-c motif chemokine ligand 13)
B: hcc-4 (mus musculus) (aka c-c motif chemokine ligand 16, pseudogene)
C: hcc-8 (homo sapiens) (aka tetratricopeptide repeat domain 23)
D: ldc (homo sapiens) (aka lumican)
E: ldc (mus musculus) (aka lumican)
F: ... | [P; P; P; P] |
<Instruct>: Given the context 'LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ccl16]
<Options>: A: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
B: ccl16 (sus scrofa) (aka c-c motif chemokine ligand 16)
C: ccl26 (homo sapiens) (aka c-c motif chemokine ligand 26)
D: c-x-c motif chemokine ligand 16 (homo sapiens) (aka c-x-c motif chemokine ligand 16)
E: interferon gamma ind... | [A] |
<Instruct>: Given the context 'Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [lec]
<Options>: A: lce (homo sapiens) (aka elovl fatty acid elongase 6)
B: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcription factor lec2-like)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: lec (homo sapiens) (aka c-c motif chemok... | [D] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lce (homo sapiens) (aka elovl fatty acid elongase 6)
B: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
D: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokin... | [N; F; B] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: ccr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
C: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
E: lec (homo sapiens) (a... | [E; J; A] |
<Instruct>: Given the context 'We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
B: ckr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
C: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: cc-ckr-9 (h... | [F; B; J] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: ccr8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
D: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif... | [G; J; A] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
C: xcr1 (homo sapiens) (aka x-c motif chemokine receptor 1)
D: gpcr8 (homo sapiens) (aka g protein-coupled receptor 62)
E: cc-ckr-6 (homo sapiens) ... | [H; I; K] |
<Instruct>: Given the context 'LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec; ccr1; ccr8]
<Options>: A: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
B: ccr1 (homo sapiens) (aka c-c motif chemokine receptor 1)
C: c-c-ckr-1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
D: cc-ckr-4 (homo sapiens) (aka c-c motif chemokine receptor 4)
E: lec2 (homo s... | [J; B; I] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: e330027i09 (mus musculus) (aka fibronectin 1)
B: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
C: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
D: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-containing transcr... | [H; O; E] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
B: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
C: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
D: lce (homo sapiens) (aka elovl fatty acid elongase 6)
E: l(2)ia109 (drosophila melanogaster) (aka ... | [B; N; A] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: l(2)ia109 (drosophila melanogaster) (aka jun-related antigen)
B: b1309 (escherichia coli str. k-12 substr. mg1655) (aka glucosylglycerate phosphorylase)
C: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
D: b3 domain-containing transcription factor lec2-lik... | [E; O; N] |
<Instruct>: Given the context 'The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [lec; rantes; i309]
<Options>: A: i-309 (mus musculus) (aka c-c motif chemokine ligand 1)
B: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
D: znf309 (homo sapiens) (aka zinc finger with krab and scan domains 3)
E: l(2r)ia109 (drosoph... | [O; H; B] |
<Instruct>: Given the context 'A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination.', select the correct biomedical concept for each mention usin... | <Mentions>: [lec]
<Options>: A: b-lec (gallus gallus) (aka c-type lectin like 1, mhcb region)
B: lec2 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
C: lec1 (homo sapiens) (aka adhesion g protein-coupled receptor l2)
D: b3 domain-containing transcription factor lec2-like (glycine max) (aka b3 domain-contai... | [E] |
<Instruct>: Given the context 'This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lec]
<Options>: A: lec1 (drosophila melanogaster) (aka parched)
B: lce (homo sapiens) (aka elovl fatty acid elongase 6)
C: lec3 (homo sapiens) (aka adhesion g protein-coupled receptor l3)
D: lec (homo sapiens) (aka c-c motif chemokine ligand 16)
E: lec2 (homo sapiens) (aka adhesion g protein-coupled recept... | [D] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: ataxin 3 (mus musculus) (aka ataxin 3)
B: mjdp1 (mus musculus) (aka dnaj heat shock protein family (hsp40) member c12)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
... | [K; K; J; I] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: nr3b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 3b)
C: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
D: mjdp1 (mus musculus) (aka dnaj heat shock protein f... | [Q; Q; P; I] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
B: hsd3b2 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
C: mjd1 (mus musculus) (aka ataxin 3)
D: sca3 (homo sapiens) (aka ataxin 3)
E: hr23b (ho... | [D; D; G; I] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [ataxin-3; mjd1; hhr23a; hhr23b]
<Options>: A: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
B: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
C: ataxin 3 (mus musculus) (aka ataxin 3)
D: hr23b (homo sapiens) (aka rad23 nucleotide excision repair protei... | [Q; Q; L; A] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [mjd1; ataxin-3]
<Options>: A: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
B: mjd (homo sapiens) (aka ataxin 3)
C: mjdl (homo sapiens) (aka ataxin 3 like)
D: mjds (homo sapiens) (aka lipin 2)
E: mjl-1 (caenorhabditis elegans) (aka abc2_membrane domain-containing protein)
F: ataxin-3 homolog (caenorhabditis... | [B; B] |
<Instruct>: Given the context 'Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD1 g... | <Mentions>: [mjd1; ataxin-3]
<Options>: A: ataxin 3 (mus musculus) (aka ataxin 3)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: dnaj homolog (drosophila melanogaster) (aka dnaj homolog)
D: mjd (mus musculus) (aka ataxin 3)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: mjdl (homo sapiens) (aka atax... | [G; G] |
<Instruct>: Given the context 'The mutant ataxin-3 forms intranuclear inclusions in cultured cells as well as in diseased human brain and also causes cell death in transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [ataxin-3]
<Options>: A: atxn3 (homo sapiens) (aka ataxin 3)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: ataxin 3 (mus musculus) (aka ataxin 3)
D: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: None of the above. | [A] |
<Instruct>: Given the context 'However, the normal function of ataxin-3 remains unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3]
<Options>: A: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
D: atxn3 (homo sapiens) (aka ataxin 3)
E: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
F: None of the above. | [D] |
<Instruct>: Given the context 'To explore the function of ataxin-3, we used the two-hybrid system to screen for the protein(s) that interacts with ataxin-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [ataxin-3]
<Options>: A: ataxin 7 like 3 (homo sapiens) (aka ataxin 7 like 3)
B: ataxin 3 (sus scrofa) (aka ataxin 3)
C: atxn3 (homo sapiens) (aka ataxin 3)
D: ataxin-3 (mus musculus) (aka ataxin 3)
E: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: rad23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
B: hhr23a (homo sapiens) (aka rad23 nucleotide excision repair protein a)
C: hhr21 (homo sapiens) (aka rad21 cohesin complex component)
D: rad23b (homo sapiens) (aka rad23 nucleotide excisi... | [F; L; A; D] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: hh23 (homo sapiens) (aka luteinizing hormone subunit beta)
B: hhr6a (homo sapiens) (aka ubiquitin conjugating enzyme e2 a)
C: tfiih/ner complex atp-dependent 5'-3' dna helicase subunit rad3 (saccharomyces cerevisiae s288c) (aka tfiih/ner complex atp-dependent ... | [N; H; D; I] |
<Instruct>: Given the context 'We found that ataxin-3 interacts with two human homologs of the yeast DNA repair protein RAD23, HHR23A and HHR23B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ataxin-3; rad23; hhr23a; hhr23b]
<Options>: A: sca3 (homo sapiens) (aka ataxin 3)
B: ataxin 3 (xenopus tropicalis) (aka ataxin 3)
C: hhr23b (homo sapiens) (aka rad23 nucleotide excision repair protein b)
D: ataxin-3 homolog (caenorhabditis elegans) (aka ataxin-3 homolog)
E: nr3b2 (homo sapiens) (aka estrog... | [A; I; Q; C] |
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