instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progen... | <Mentions>: [cxcr3; gamma ip-10; mig]
<Options>: A: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
C: il-10c (homo sapiens) (aka interleukin 19)
D: ip-10 (mus musculus) (aka c-x-c motif chemokine ligand 10)
E: mig9 (homo sapiens) (aka s100 calcium bin... | [O; A; F] |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progen... | <Mentions>: [cxcr3; gamma ip-10; mig]
<Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
C: mig9 (homo sapiens) (aka s100 calcium binding protein p)
D: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3... | [D; H; J] |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progen... | <Mentions>: [gm-csf; cd34]
<Options>: A: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
B: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
C: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E... | [F; B] |
<Instruct>: Given the context 'These results indicate that CXCR3-gamma IP-10 and CXCR3-Mig receptor-ligand pairs, as well as the effects of GM-CSF on them, may be especially important in the cytokine/chemokine environment for the physiologic and pathophysiologic events of differentiation of CD34(+) hematopoietic progen... | <Mentions>: [gm-csf; cd34]
<Options>: A: cd34 molecule (gallus gallus) (aka cd34 molecule)
B: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
C: cd34 (sus scrofa) (aka cd34 molecule)
D: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
E: cd340 (homo sapiens) ... | [H; I] |
<Instruct>: Given the context 'These processes include transmigration, relocation, differentiation, and maturation of CD34(+) hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [cd34]
<Options>: A: cd34 molecule (homo sapiens) (aka cd34 molecule)
B: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
C: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: cd34 (sus scrofa) (aka cd34 molecule)
F: None of t... | [A] |
<Instruct>: Given the context 'HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gp120; gp160]
<Options>: A: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 4)
B: gag (human immunodeficiency virus 1) (aka pr55(gag))
C: py160 (homo sapiens) (aka insulin receptor substrate 4)
D: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
... | [D; D] |
<Instruct>: Given the context 'HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gp120; gp160]
<Options>: A: vif (human immunodeficiency virus 1) (aka vif)
B: gp160 (mus musculus) (aka leucyl/cystinyl aminopeptidase)
C: gp160 (rattus norvegicus) (aka leucyl and cystinyl aminopeptidase)
D: envelope glycoprotein 150 (human gammaherpesvirus 4) (aka envelope glycoprotein 150)
E: vpr (human... | [I; I] |
<Instruct>: Given the context 'Recently, the alpha-chemokine receptor CXCR4 has been reported to mediate apoptosis in neuronal cells and in CD4(+) and CD8(+) T cells after its binding to HIV-1 envelope proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [alpha-chemokine receptor cxcr4]
<Options>: A: c-x-c motif chemokine receptor 4 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 4)
B: c-c chemokine receptor type 8 (xenopus tropicalis) (aka c-c chemokine receptor type 8)
C: c-x-c motif chemokine receptor 4 (homo sapiens) (aka c-x-c motif chemokine ... | [C] |
<Instruct>: Given the context 'In the current study, it was observed that human umbilical vein endothelial cells (HUVEC) undergo apoptosis after their treatment with the HIV-1 envelope proteins gp120/160.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [gp120/160]
<Options>: A: mg160 (homo sapiens) (aka golgi glycoprotein 1)
B: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
C: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
D: mg-160 (rattus norvegicus) (aka golgi glycoprotein 1)
E: gp160 (rattu... | [C] |
<Instruct>: Given the context 'Anti-CXCR4 monoclonal antibody decreased HIV-1 gp120/160-induced apoptosis, suggesting that the CXCR4 chemokine receptor mediates the apoptotic effects of these HIV envelope glycoproteins.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [cxcr4; gp120/160]
<Options>: A: atypical chemokine receptor 4 (xenopus tropicalis) (aka atypical chemokine receptor 4)
B: gp160 (homo sapiens) (aka glutamyl aminopeptidase)
C: chemokine (c motif) receptor 1 (xenopus tropicalis) (aka chemokine (c motif) receptor 1)
D: hhv5wtgp160 (human betaherpesvirus 5) (... | [F; G] |
<Instruct>: Given the context 'Anti-CXCR4 monoclonal antibody decreased HIV-1 gp120/160-induced apoptosis, suggesting that the CXCR4 chemokine receptor mediates the apoptotic effects of these HIV envelope glycoproteins.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [cxcr4; gp120/160]
<Options>: A: mg160 (homo sapiens) (aka golgi glycoprotein 1)
B: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
C: c-c chemokine receptor type 8 (xenopus tropicalis) (aka c-c chemokine receptor type 8)
D: gp160 (homo sapiens) (aka glutamyl aminop... | [G; B] |
<Instruct>: Given the context 'Further studies revealed that caspases play an important role in this process because the pretreatment of cells with a general caspase enzyme inhibitor decreased the extent of HUVEC apoptosis induced by gp120/160.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [gp120/160]
<Options>: A: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
B: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
C: mg-160 (homo sapiens) (aka golgi glycoprotein 1)
D: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain ... | [A] |
<Instruct>: Given the context 'Further studies revealed that caspases play an important role in this process because the pretreatment of cells with a general caspase enzyme inhibitor decreased the extent of HUVEC apoptosis induced by gp120/160.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [gp120/160]
<Options>: A: mg-160 (homo sapiens) (aka golgi glycoprotein 1)
B: gp120 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 4)
C: gp160 (rattus norvegicus) (aka leucyl and cystinyl aminopeptidase)
D: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
E: None of the above... | [E] |
<Instruct>: Given the context 'In addition, it was found that caspase-3 was activated on HIV-1 gp120/160 treatment of these cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [caspase-3; gp120/160]
<Options>: A: caspase-3 (xenopus tropicalis) (aka caspase 3, gene 2)
B: ice-lap3 (homo sapiens) (aka caspase 7)
C: mg-160 (homo sapiens) (aka golgi glycoprotein 1)
D: env (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
E: casp-3 (mus musculus) (ak... | [H; D] |
<Instruct>: Given the context 'In addition, it was found that caspase-3 was activated on HIV-1 gp120/160 treatment of these cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [caspase-3; gp120/160]
<Options>: A: envelope surface glycoprotein gp160, precursor (human immunodeficiency virus 1) (aka envelope surface glycoprotein gp160, precursor)
B: mg-160 (rattus norvegicus) (aka golgi glycoprotein 1)
C: caspase-3 (xenopus tropicalis) (aka caspase 3, gene 2)
D: caspase-3 (drosophil... | [E; A] |
<Instruct>: Given the context 'It was also observed that gp120/160 treatment slightly increased the expression of the pro-apoptotic molecule Bax.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gp120/160; bax]
<Options>: A: gp160 (homo sapiens) (aka glutamyl aminopeptidase)
B: bak-2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
C: bak (homo sapiens) (aka bcl2 antagonist/killer 1)
D: bcl2 associated x, apoptosis regulator (homo sapiens) (aka bcl2 associated x, apoptosis regulator)
E: ... | [J; D] |
<Instruct>: Given the context 'It was also observed that gp120/160 treatment slightly increased the expression of the pro-apoptotic molecule Bax.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gp120/160; bax]
<Options>: A: hhv5wtgp160 (human betaherpesvirus 5) (aka membrane protein us30)
B: bak1 (homo sapiens) (aka bcl2 antagonist/killer 1)
C: mg-160 (homo sapiens) (aka golgi glycoprotein 1)
D: mg-160 (rattus norvegicus) (aka golgi glycoprotein 1)
E: bcl2 apoptosis regulator (homo sapiens) (aka ... | [J; F] |
<Instruct>: Given the context 'These results suggest that HIV-1 envelope glycoproteins can disrupt endothelial integrity through the interaction with CXCR4, thereby facilitating virus transit out of the bloodstream and contributing to the vascular injury syndromes seen in acquired immunodeficiency syndrome.', select th... | <Mentions>: [cxcr4]
<Options>: A: c-c motif chemokine receptor 4 (homo sapiens) (aka c-c motif chemokine receptor 4)
B: c-c chemokine receptor type 8 (xenopus tropicalis) (aka c-c chemokine receptor type 8)
C: c-x-c motif chemokine receptor 4 (homo sapiens) (aka c-x-c motif chemokine receptor 4)
D: atypical chemokine r... | [C] |
<Instruct>: Given the context 'Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome).
', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [collagen xviii]
<Options>: A: collagen type xxviii alpha 1 chain (homo sapiens) (aka collagen type xxviii alpha 1 chain)
B: collagen alpha-1(xxviii) chain (xenopus tropicalis) (aka collagen alpha-1(xxviii) chain)
C: collagen, type xxviii, alpha 1 (xenopus tropicalis) (aka collagen, type xxviii, alpha 1)
D:... | [D] |
<Instruct>: Given the context 'Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome).
', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [collagen xviii]
<Options>: A: collagen type xxviii alpha 1 chain (homo sapiens) (aka collagen type xxviii alpha 1 chain)
B: collagen, type xxviii, alpha 1 (xenopus tropicalis) (aka collagen, type xxviii, alpha 1)
C: collagen alpha-1(xxviii) chain (xenopus tropicalis) (aka collagen alpha-1(xxviii) chain)
D:... | [E] |
<Instruct>: Given the context 'We reconstructed the haplotypes of this family with ten additional markers (five were novel) and narrowed the candidate interval to a region of < 245 kb, which contains 24 expressed sequence tags, the KIAA0958 gene and the 5' end of the COL18A1 gene.', select the correct biomedical concep... | <Mentions>: [kiaa0958; col18a1]
<Options>: A: chromosome 3 c8orf58 homolog (xenopus tropicalis) (aka chromosome 3 c8orf58 homolog)
B: col18a1 (rattus norvegicus) (aka collagen type xviii alpha 1 chain)
C: kiaa0859 (homo sapiens) (aka methyltransferase 13, eef1a n-terminus and k55)
D: col18a1 (mus musculus) (aka collage... | [K; E] |
<Instruct>: Given the context 'We reconstructed the haplotypes of this family with ten additional markers (five were novel) and narrowed the candidate interval to a region of < 245 kb, which contains 24 expressed sequence tags, the KIAA0958 gene and the 5' end of the COL18A1 gene.', select the correct biomedical concep... | <Mentions>: [kiaa0958; col18a1]
<Options>: A: chromosome 10 c17orf58 homolog (xenopus tropicalis) (aka chromosome 10 c17orf58 homolog)
B: chromosome 5 c6orf58 homolog (xenopus tropicalis) (aka chromosome 5 c6orf58 homolog)
C: col18a1 (bos taurus) (aka collagen type xviii alpha 1 chain)
D: col18a1.s (xenopus laevis) (ak... | [K; H] |
<Instruct>: Given the context 'We identified a homozygous mutation at the AG consensus acceptor splice site of COL18A1 intron 1 exclusively among the 12 KS patients, which was not found among 140 control chromosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [col18a1]
<Options>: A: col18a1.s (xenopus laevis) (aka collagen type xviii alpha 1 s homeolog)
B: col18a1 (homo sapiens) (aka collagen type xviii alpha 1 chain)
C: col18a1 (mus musculus) (aka collagen, type xviii, alpha 1)
D: col18a1 (bos taurus) (aka collagen type xviii alpha 1 chain)
E: col18a1 (rattus n... | [B] |
<Instruct>: Given the context 'This mutation predicts the creation of a stop codon in exon 4 and therefore the truncation of the alpha1(XVIII) collagen short form, which was expressed in human adult retina.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [alpha1(xviii) collagen]
<Options>: A: collagen type xviii alpha 1 chain (sus scrofa) (aka collagen type xviii alpha 1 chain)
B: collagen, type xxviii, alpha 1 (xenopus tropicalis) (aka collagen, type xxviii, alpha 1)
C: collagen alpha-1(xxviii) chain (xenopus tropicalis) (aka collagen alpha-1(xxviii) chain... | [D] |
<Instruct>: Given the context 'These findings provide evidence that KS is caused by mutations in COL18A1 which, therefore, has a major role in determining the retinal structure as well as in the closure of the neural tube.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [col18a1]
<Options>: A: col18a1 (oryctolagus cuniculus) (aka collagen type xviii alpha 1 chain)
B: col18a1 (xenopus laevis) (aka collagen type xviii alpha 1 l homeolog)
C: col18a1 (bos taurus) (aka collagen type xviii alpha 1 chain)
D: col18a1 (homo sapiens) (aka collagen type xviii alpha 1 chain)
E: col18a... | [D] |
<Instruct>: Given the context 'CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
B: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
C: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
D: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
E: ciks (homo sapie... | [E] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
B: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
C: nemep (mus musculus) (aka small integral membrane protein 43)
D: nemo/nlk (drosophila melanogaster) (aka nemo)... | [E; K; G; G] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nemp1 (homo sapiens) (aka nuclear envelope integral membrane protein 1)
B: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
C: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
D: ikka (mus musculus) (a... | [G; H; J; J] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
B: nemo/nlk (drosophila melanogaster) (aka nemo)
C: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
D: ikk-beta (xenopus tropicalis) (aka inhibitor of kappa light p... | [F; M; O; O] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
B: nfkbia (homo sapiens) (aka nfkb inhibitor alpha)
C: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
D: ik... | [D; P; A; A] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkalpha; ikkbeta; nemo; nf-kappab essential modulator]
<Options>: A: ikk-1 (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
B: ikka (mus musculus) (aka conserved helix-loop-helix ubiquitous kinase)
C: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase r... | [A; O; C; C] |
<Instruct>: Given the context 'IKKalpha and IKKbeta are two catalytic subunits of a core IKK complex that also contains the regulatory subunit NEMO (NF-kappaB essential modulator)/IKKgamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ikkgamma]
<Options>: A: ikk-beta (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
B: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
C: ikki (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
D: ikk-gamm... | [D] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: nemo (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase regulatory subunit gamma)
B: cisk (homo sapiens) (aka serum/glucocorticoid regulated kinase family member 3)
C: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
D: ikka (homo sapiens)... | [K; A; A] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: nemo like kinase, pseudogene 1 (mus musculus) (aka nemo like kinase, pseudogene 1)
B: crkas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
D: ikkgammabeta (drosophila melanogaster)... | [F; N; N] |
<Instruct>: Given the context 'Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ciks; nemo; ikkgamma]
<Options>: A: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
B: ciks (homo sapiens) (aka traf3 interacting protein 2)
C: nemp1 (mus musculus) (aka nuclear envelope integral membrane protein 1)
D: ciks (mus musculus) (aka traf3 interacting protein 2)
E: cisk (homo... | [B; L; L] |
<Instruct>: Given the context 'When ectopically expressed, CIKS stimulates IKK and SAPK/JNK kinases and it transactivates an NF-kappaB-dependent reporter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [ciks]
<Options>: A: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
B: cik1p (saccharomyces cerevisiae s288c) (aka cik1p)
C: ciks (homo sapiens) (aka traf3 interacting protein 2)
D: cisk (homo sapiens) (aka serum/glucocorticoid regulated kinase family member 3)
E: crkas (homo sapie... | [C] |
<Instruct>: Given the context 'CIKS may help to connect upstream signaling events to IKK and SAPK/JNK modules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ciks]
<Options>: A: ciks (homo sapiens) (aka traf3 interacting protein 2)
B: cisk (mus musculus) (aka serum/glucocorticoid regulated kinase 3)
C: cisk (homo sapiens) (aka serum/glucocorticoid regulated kinase family member 3)
D: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
E: cs... | [A] |
<Instruct>: Given the context 'CIKS could coordinate the activation of two stress-induced signaling pathways, functions reminiscent of those noted for tumor necrosis factor receptor-associated factor adaptor proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [ciks]
<Options>: A: ciks (homo sapiens) (aka traf3 interacting protein 2)
B: csk (homo sapiens) (aka c-terminal src kinase)
C: citk (homo sapiens) (aka citron rho-interacting serine/threonine kinase)
D: adapter protein ciks (xenopus tropicalis) (aka adapter protein ciks)
E: cik1p (saccharomyces cerevisiae ... | [A] |
<Instruct>: Given the context 'Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad4 (homo sapiens) (aka smad family member 4)
E: smad family member 5 (homo sapiens) (aka ... | [D] |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 3 (homo sapiens) (aka smad family member 3)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: smad family member 5 (... | [C; G] |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
B: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
C: smad family member 3 (mus musculus) (aka smad family member 3)
D: smad family member 4 (mus musculus) (aka smad family member 4)
E: mad... | [J; G] |
<Instruct>: Given the context 'Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad3; smad4]
<Options>: A: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
B: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
C: madh4 (homo sapiens) (aka smad family member 4)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 4 (xenopus tropicalis) (aka sm... | [G; C] |
<Instruct>: Given the context 'We investigated the functional consequences of four missense mutations in the Smad4 amino-terminal domain found in human tumors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [smad4]
<Options>: A: smad family member 5 (homo sapiens) (aka smad family member 5)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad4 (homo sapiens) (aka smad family member 4)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member ... | [C] |
<Instruct>: Given the context 'The mutant proteins were found to have impaired abilities to bind DNA although they were fully capable of forming complexes with Smad3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [smad3]
<Options>: A: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
B: smad3 (mus musculus) (aka smad family member 3)
C: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
D: mad3 (homo sapiens) (max dimerization protein 3 ... | [E] |
<Instruct>: Given the context 'All four Smad4 mutants showed decreased protein stability compared to wild-type Smad4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad4]
<Options>: A: dpc4 (homo sapiens) (aka smad family member 4)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 4 (xenopus tropicalis) (aka smad family member 4... | [A] |
<Instruct>: Given the context 'Two of the Smad4 mutants (G65V and P130S) were translocated to the nucleus and were capable of transactivating a Smad-dependent promoter in a ligand-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [smad4]
<Options>: A: smad family member 4 (mus musculus) (aka smad family member 4)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: dpc4 (homo sapiens) (aka s... | [E] |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [smad3; smad4]
<Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
C: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
D: madh3 (homo sapiens) (aka smad famil... | [D; E] |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [smad3; smad4]
<Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: smad3 (mus musculus) (aka smad family member 3)
C: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: smad family member 3 (xenopus tropicalis) (aka smad fa... | [J; G] |
<Instruct>: Given the context 'Moreover, we demonstrate here the critical importance of two basic residues in the beta-hairpin loop of Smad3 or Smad4 for DNA binding, consistent with predictions from the Smad3 crystal structure.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [smad3; smad4]
<Options>: A: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
D: smad4 (homo sapiens) (aka smad famil... | [J; D] |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept for each mention ... | <Mentions>: [smad4; smad3]
<Options>: A: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
B: smad family member 3 (xenopus tropicalis) (aka smad family member 3)
C: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
D: smad3 (mus musculus)... | [F; G] |
<Instruct>: Given the context 'In addition, our results reveal that in the TGF-beta-induced heteromeric signaling complex, loss of DNA binding of Smad4 can be compensated by Smad3, however, both Smad3 and Smad4 are needed for efficient DNA binding and signaling.', select the correct biomedical concept for each mention ... | <Mentions>: [smad4; smad3]
<Options>: A: smad4 (mus musculus) (aka smad family member 4)
B: smad3 (xenopus laevis) (smad family member 3 s homeolog (xenopus laevis)) (aka smad family member 3 s homeolog)
C: smad family member 3 (homo sapiens) (aka smad family member 3)
D: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)... | [J; C] |
<Instruct>: Given the context 'In conclusion, mutations in the amino-terminal domain of Smad4, that are found in cancer, show loss of multiple functional properties which may contribute to tumorigenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [smad4]
<Options>: A: smad4 (drosophila melanogaster) (aka medea)
B: smad4 (homo sapiens) (aka smad family member 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: mad4 (homo sapiens) (aka max dimerization protein ... | [B] |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; doublecortin]
<Options>: A: doublecortin (sus scrofa) (aka doublecortin)
B: doublecortin domain containing 2 (xenopus tropicalis) (aka doublecortin domain containing 2)
C: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
D: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
E: lis7 (homo sa... | [F; J] |
<Instruct>: Given the context 'Interaction between LIS1 and doublecortin, two lissencephaly gene products.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; doublecortin]
<Options>: A: doublecortin (homo sapiens) (aka doublecortin)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
D: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
E: doublecortin (xenopus tropicalis) (aka doublecortin)
F: doubl... | [G; A] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: doublecortin (homo sapiens) (aka doublecortin)
B: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
C: dcx (rattus norvegicus) (aka doublecortin)
D: lis3 (homo sapiens) (aka tubulin alpha 1a)
E: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
F: lis4 ... | [I; A; I] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lisx (homo sapiens) (aka do... | [C; M; C] |
<Instruct>: Given the context 'Mutations in either LIS1 or DCX are the most common cause for type I lissencephaly.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx; type i lissencephaly]
<Options>: A: lis9 (homo sapiens) (aka microtubule actin crosslinking factor 1)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: dcx (homo sapiens) (aka doublecortin)
D: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
E: dcx (mus musculus) (aka dou... | [F; C; F] |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
B: dcx (homo sapiens) (aka doublecortin)
C: doublecortin (xenopus tropicalis) (aka doublecortin)
D: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
E: lis6 (homo sapiens) (aka katanin regulatory s... | [J; B] |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
B: dcx (oryctolagus cuniculus) (aka doublecortin)
C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
E: lis7 (homo sa... | [D; J] |
<Instruct>: Given the context 'Here we report that LIS1 and DCX interact physically both in vitro and in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: dcx (mus musculus) (aka doublecortin)
C: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
D: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
E: lispr1 (homo sapiens) (aka s1pr... | [A; G] |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: dcx (homo sapiens) (aka doublecortin)
B: dcx (rattus norvegicus) (aka doublecortin)
C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: dcx (xenopus tropicalis) (aka doublecortin)
E: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
F: lis6 (homo sapiens) (a... | [A; J] |
<Instruct>: Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: lis-1 (caenorhabditis elegans) (aka lissencephaly-1 homolog)
E: dcxr (homo s... | [I; B] |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [dcx; lis1]
<Options>: A: doublecortin (xenopus tropicalis) (aka doublecortin)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: dcx (oryctolagus cuniculus) (aka doublecortin)
E: dcxr (homo sapiens) (... | [J; C] |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [dcx; lis1]
<Options>: A: dcx (xenopus tropicalis) (aka doublecortin)
B: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: dcx (homo sapiens) (aka doublecortin)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b... | [D; E] |
<Instruct>: Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [dcx; lis1]
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lis-1 (drosophila melanogaster) (aka lissencephaly-1)
C: lis3 (homo sapiens) (aka tubulin alpha 1a)
D: dcx (xenopus tropicalis) (aka doublecortin)
E: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
F: lis1 (homo sapiens... | [J; F] |
<Instruct>: Given the context 'In addition, we demonstrate homodimerization of DCX in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx]
<Options>: A: doublecortin (rattus norvegicus) (aka doublecortin)
B: doublecortin (homo sapiens) (aka doublecortin)
C: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: doublecortin (xenopus tropicalis) (aka doublecortin)
E: dcx (oryctolagus cuniculus) (aka doublecortin)
F: None of the ... | [B] |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (homo sapiens) (aka doublecortin)
B: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: dcx (mus musculus) (aka doublecortin)
E: dcxr (danio rerio) (aka dicarbonyl/l-xy... | [C; A] |
<Instruct>: Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
B: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
C: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
D: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
E: ... | [C; E] |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: doublecortin (rattus norvegicus) (aka doublecortin)
B: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
C: dcx (xenopus tropicalis) (aka doublecortin)
D: lis1 (drosophila melanogaster) (aka lissencephaly-1)
E: doublecortin (homo sapiens) (aka doublecortin)
F: lis1 (homo sap... | [F; E] |
<Instruct>: Given the context 'LIS1 and DCX interact with tubulin and microtubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: dcx (oryctolagus cuniculus) (aka doublecortin)
B: dcx (mus musculus) (aka doublecortin)
C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
D: lis3 (homo sapiens) (aka tubulin alpha 1a)
E: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory su... | [E; J] |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: dcx (homo sapiens) (aka doublecortin)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: dcx (xenopus tropicalis) (aka doublecortin)
D: dcxr (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
E: dcx (oryctolagus cuniculus) (aka doublecortin)
F: lis6 (homo sapiens) (aka katanin ... | [A; G] |
<Instruct>: Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dcx; lis1]
<Options>: A: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
D: dcx (mus musculus) (aka doublecortin)
E: lis3 (homo sapiens) (aka tubul... | [G; B] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [lis1; dcx]
<Options>: A: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
B: dcx (xenopus tropicalis) (aka doublecortin)
C: lis4 (homo sapiens) (aka nude neurodevelopment protein 1)
D: dcx (homo sapiens) (aka doublecortin)
E: dcx (mus musculus) (aka doublecortin)... | [A; D] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [lis1; dcx]
<Options>: A: lis3 (homo sapiens) (aka tubulin alpha 1a)
B: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
C: dcx (mus musculus) (aka doublecortin)
D: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
E: dcx (homo sapiens) (aka doublecortin)
F: doublecortin (rattus norvegicus) (aka d... | [H; E] |
<Instruct>: Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [lis1]
<Options>: A: lis6 (homo sapiens) (aka katanin regulatory subunit b1)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: lis3 (homo sapiens) (aka tubulin alpha 1a)
D: lispr1 (homo sapiens) (aka s1pr1 divergent transcript)
E: lis7 (homo sapiens) (aka cyc... | [B] |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: lis1 (drosophila melanogaster) (aka lissencephaly-1)
B: lis1 (homo sapiens) (aka platelet activating factor acetylhydrolase 1b regulatory subunit 1)
C: doublecortin (homo sapiens) (aka doublecortin)
D: doublecortin (rattus norvegicus) (aka doublecortin)
E: lispr1 (homo sapiens) (ak... | [B; C] |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: doublecortin (homo sapiens) (aka doublecortin)
B: lis7 (homo sapiens) (aka cyclin dependent kinase 5)
C: lis1 (drosophila melanogaster) (aka lissencephaly-1)
D: doublecortin (rattus norvegicus) (aka doublecortin)
E: dcx (oryctolagus cuniculus) (aka doublecortin)
F: lispr1 (homo sap... | [J; A] |
<Instruct>: Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lis1; dcx]
<Options>: A: doublecortin (homo sapiens) (aka doublecortin)
B: lis3 (homo sapiens) (aka tubulin alpha 1a)
C: lissencephaly-1 homolog (caenorhabditis elegans) (aka lissencephaly-1 homolog)
D: dcxr (danio rerio) (aka dicarbonyl/l-xylulose reductase)
E: lis7 (homo sapiens) (aka cyclin dependent ki... | [I; A] |
<Instruct>: Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.
Kv4.2 potassium channels play a critical role in postsynaptic excitability.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
B: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
C: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
D: kir4.2 (homo sapiens) ... | [C] |
<Instruct>: Given the context 'Immunocytochemical studies reveal a somatodendritic Kv4.2 expression pattern, with the channels concentrated mainly at dendritic spines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [kv4.2]
<Options>: A: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
B: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
C: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
D: kv8.2 (homo sapiens)... | [A] |
<Instruct>: Given the context 'The molecular mechanism that underlies the localization of Kv4.2 to this subcellular region is unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
B: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
C: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
D: kv8.2 (homo sapiens) (aka pota... | [E] |
<Instruct>: Given the context 'We used the yeast two-hybrid system to identify the Kv4.2-associated proteins that are involved in channel localization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [kv4.2]
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
C: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
D: kv7.2 (homo sapiens) (aka pota... | [E] |
<Instruct>: Given the context 'Here we demonstrate a direct interaction between Kv4.2 and the actin-binding protein, filamin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kv4.2]
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
C: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
D: kv4.2 (homo sapiens) (aka pot... | [D] |
<Instruct>: Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [kv4.2]
<Options>: A: kv6.4 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 4)
B: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
C: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
D: kv4.2 (homo sapiens)... | [D] |
<Instruct>: Given the context 'To examine the functional consequences of this interaction, we expressed Kv4.2 in filamin(+) and filamin(-) cells and performed immunocytochemical and electrophysiological analyses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [kv4.2]
<Options>: A: kv7.2 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 2)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv4.2 (mus musculus) (aka potassium voltage-gated channel, shal-related family, member 2)
D: kv7.4 (homo sapiens) (aka p... | [B] |
<Instruct>: Given the context 'Our results indicate that Kv4.2 colocalizes with filamin at filopodial roots in filamin(+) cells but shows a nonspecific expression pattern in filamin(-) cells, with no localization to filopodial roots.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [kv4.2]
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
D: kv4.2 (rattus norvegicus) (aka... | [B] |
<Instruct>: Given the context 'Our results indicate that Kv4.2 colocalizes with filamin at filopodial roots in filamin(+) cells but shows a nonspecific expression pattern in filamin(-) cells, with no localization to filopodial roots.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [kv4.2]
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kv9.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily s member 2)
D: kv4.2 (mus musculus) (aka... | [E] |
<Instruct>: Given the context 'Furthermore, the magnitude of whole-cell Kv4.2 current density is approximately 2.7-fold larger in filamin(+) cells as compared with these currents in filamin(-) cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [kv4.2]
<Options>: A: kir4.2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 15)
B: kv8.2 (homo sapiens) (aka potassium voltage-gated channel modifier subfamily v member 2)
C: kv4.2 (homo sapiens) (aka potassium voltage-gated channel subfamily d member 2)
D: kv4.2 (mus musculus)... | [C] |
<Instruct>: Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', select the correct biomedical conce... | <Mentions>: [kv4.2]
<Options>: A: kv4 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 1)
B: kv4.2 (rattus norvegicus) (aka potassium voltage-gated channel subfamily d member 2)
C: kv7.4 (homo sapiens) (aka potassium voltage-gated channel subfamily q member 4)
D: kv8.2 (homo sapiens) (aka potassiu... | [E] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: tmprss3 (homo sapiens) (transmembrane serine protease 3 (homo sapiens)) (aka transmembrane serine protease 3)
B: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5)
C: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
D: dfnb40 (homo sapiens... | [A; A; A; A] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: tmprss3 (homo sapiens) (transmembrane serine protease 4 (homo sapiens)) (aka transmembrane serine protease 4)
B: dfn6 (homo sapiens) (aka small muscle protein x-linked)
C: tmprss2 (homo sapiens) (aka transmembrane serine protease 2)
D: dfnb109 (homo sapiens) (a... | [G; G; G; G] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: echos1 (xenopus tropicalis) (aka transmembrane serine protease 3)
B: dfnb18 (homo sapiens) (aka ush1 protein network component harmonin)
C: tmprss3 (homo sapiens) (transmembrane serine protease 4 (homo sapiens)) (aka transmembrane serine protease 4)
D: dfnb109 ... | [P; P; P; P] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: dfna10 (homo sapiens) (aka eya transcriptional coactivator and phosphatase 4)
B: tmprss3 (bos taurus) (aka transmembrane serine protease 3)
C: dfnb3 (homo sapiens) (aka myosin xva)
D: dfn6 (homo sapiens) (aka small muscle protein x-linked)
E: dfnb15 (homo sapie... | [O; O; O; O] |
<Instruct>: Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', select the correct biomedical concept for each m... | <Mentions>: [tmprss3; echos1; dfnb10; dfnb8]
<Options>: A: echo virus (serotypes 4, 6, 11, 19) sensitivity (homo sapiens) (aka echo virus (serotypes 4, 6, 11, 19) sensitivity)
B: dfh (drosophila melanogaster) (distal of forkhead (drosophila melanogaster)) (aka distal of forkhead)
C: transmembrane serine protease 3 (hom... | [C; C; C; C] |
<Instruct>: Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', select the correct biomedical concept... | <Mentions>: [dfnb10]
<Options>: A: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
B: dfna10 (homo sapiens) (aka eya transcriptional coactivator and phosphatase 4)
C: dfnb40 (homo sapiens) (aka deafness, autosomal recessive 40)
D: dfnb20 (homo sapiens) (aka deafness, autosomal recessive 20)
E: dfnb9 (homo s... | [A] |
<Instruct>: Given the context 'A mutation in a splice-acceptor site, resulting in a 4-bp insertion in the mRNA and a frameshift, was detected in childhood onset deafness (DFNB8).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [dfnb8]
<Options>: A: dfnb3 (homo sapiens) (aka myosin xva)
B: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5)
C: dfna8 (homo sapiens) (aka tectorin alpha)
D: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
E: dfnb10 (homo sapiens) (aka transmembrane serine protease 3)
F: None of the... | [E] |
<Instruct>: Given the context 'A mutation in a splice-acceptor site, resulting in a 4-bp insertion in the mRNA and a frameshift, was detected in childhood onset deafness (DFNB8).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [dfnb8]
<Options>: A: dfna8 (homo sapiens) (aka tectorin alpha)
B: dfnb5 (homo sapiens) (aka deafness, autosomal recessive 5)
C: dfnb4 (homo sapiens) (aka solute carrier family 26 member 4)
D: dfnb3 (homo sapiens) (aka myosin xva)
E: None of the above. | [E] |
<Instruct>: Given the context 'A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2]
<Options>: A: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
B: brca2 (homo sapiens) (aka brca2 dna repair associated)
C: fancd2 (homo sapiens) (aka fa complementation group d2)
D: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans)... | [B] |
<Instruct>: Given the context 'Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca2]
<Options>: A: fancb (homo sapiens) (aka fa complementation group b)
B: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
C: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
D: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair... | [D] |
<Instruct>: Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [brca2]
<Options>: A: fancd2 (homo sapiens) (aka fa complementation group d2)
B: palb2 (homo sapiens) (aka partner and localizer of brca2)
C: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
D: fancb (homo sapiens) (aka fa... | [E] |
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