instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
C: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
D: adam metallopeptidase domain 10 (homo sapiens) (aka adam m... | [D; J] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
B: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
C: metalloproteinase adam10-like (xenopus tropicalis) (aka... | [A; E] |
<Instruct>: Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [l1]
<Options>: A: l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhes... | [D] |
<Instruct>: Given the context 'Release of L1 is enhanced by shedding inducers such as phorbol ester and pervanadate, but it is also enhanced by depletion of cellular cholesterol with methyl-beta-cyclodextrin (MCD).', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: l1 cell adhesion mole... | [A] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
D: cyclin l1 (homo sapiens) (aka cyclin l1)
E: l1 cell adhesion mo... | [F; E] |
<Instruct>: Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1]
<Options>: A: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
B: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: l1 cell adhesion molecule (xenopus tro... | [I; F] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [l1; adam10]
<Options>: A: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
B: adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
C: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
D: adam metallopep... | [I; D] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [l1; adam10]
<Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: adam15 (homo sapiens) (aka adam metallopeptidase domain 15)
D: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabdit... | [J; I] |
<Instruct>: Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [l1; adam10]
<Options>: A: adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
B: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain... | [C; G] |
<Instruct>: Given the context 'L1 cleavage occurred in isolated vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion mo... | [D] |
<Instruct>: Given the context 'L1-containing microvesicles could trigger haptotactic cell migration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
... | [C] |
<Instruct>: Given the context 'Only the neural L1 form carrying the RSLE signal for clathrin-dependent endocytosis was recruited and cleaved in vesicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [l1]
<Options>: A: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
B: l1.1 (mus musculus) (aka skull morphology 1)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: adhesion g protein-coupled receptor l1 (homo sapiens) (aka adhesion g protein-coupled receptor l1)
E: cell adhesion molec... | [A] |
<Instruct>: Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: cyclin l1 (homo sapiens) (aka cyclin l1)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
... | [C] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Mentions>: [l1; adam10]
<Options>: A: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
C: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
D: lethal (1) l1 (drosophila melanogaster) (aka lethal (1) l1)
E: l1 c... | [E; F] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Mentions>: [l1; adam10]
<Options>: A: ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens)) (aka adam metallopeptidase domain 10)
B: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
C: l1.1 (mus musculus) (aka skull morphology 1)
D: l(1)l1 (drosophila melanogaster) ... | [I; A] |
<Instruct>: Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', select the correct bi... | <Mentions>: [l1; adam10]
<Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: l1.1 (mus musculus) (aka skull morphology 1)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
E: disintegrin and met... | [J; G] |
<Instruct>: Given the context 'The findings establish a novel role for ADAM10 as a vesicle-based protease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10]
<Options>: A: adam-ts10 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 10)
B: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
C: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
D: adam9 (homo sapiens) (aka adam metallope... | [E] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: yaf2 (sus scrofa) (aka yy1 associated factor 2)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
D: yaf2 (bos taurus) (aka yy1 assoc... | [I; F] |
<Instruct>: Given the context 'Yaf2 inhibits Myc biological function.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: yaf2 (homo sapiens) (aka yy1 associated factor 2)
B: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
C: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
D: yaf... | [A; I] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: l-myc (homo sapiens) (aka mycl proto-oncogene, bhlh transcriptio... | [L; G; C] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
B: mycl2 (homo sapiens) (aka mycl pseudogene 1)
C: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-oncogene, bhlh transcription factor)
D: mycl proto-onc... | [H; J; D] |
<Instruct>: Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [myc; mycn; mycl]
<Options>: A: l-myc (mus musculus) (aka v-myc avian myelocytomatosis viral oncogene lung carcinoma derived)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: mycn (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
D: c-myc (homo sapiens)... | [D; C; O] |
<Instruct>: Given the context 'The Myc protein is the best studied member of this family and is involved in cell cycle regulation, differentiation and cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [myc]
<Options>: A: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculu... | [D] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [yaf2; mycn]
<Options>: A: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
B: yaf1 (homo sapiens) (aka histone deacetylase 2)
C: yaf2 (bos taurus) (aka yy1 associated factor 2)
D: mycn proto-oncogene, bhlh transcription factor (danio rerio) (aka mycn proto-... | [H; J] |
<Instruct>: Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [yaf2; mycn]
<Options>: A: yaf1 (homo sapiens) (aka histone deacetylase 2)
B: yaf2-a (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis)) (aka yy1 associated factor 2 s homeolog)
C: n-myc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
D: mycn proto-oncogene, bhlh trans... | [E; C] |
<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
C: yaf2 (bos taurus) (aka yy1 associated factor 2)
D: myc proto-oncogene, bhlh trans... | [J; D] |
<Instruct>: Given the context 'Here we show that Yaf2 also binds to the Myc protein in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [yaf2; myc]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: yaf2 (homo sapiens) (aka yy1 associated factor 2)
D: myc-like oncogene, s-myc protein (mus musculus) (ak... | [C; J] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
B: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
C: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
D: mycn proto-oncogene, bhlh transcrip... | [D; H; B] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: mycn, opposite strand (mus musculus) (aka mycn, opposite strand)
B: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transferase activating protein pex22)
C: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
D: yaf2 (bos taurus) (aka yy1 ass... | [J; N; C] |
<Instruct>: Given the context 'In contrast to the activating effect on MycN function, Yaf2 inhibits Myc mediated transactivation and transformation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mycn; yaf2; myc]
<Options>: A: yaf2 (homo sapiens) (aka yy1 associated factor 2)
B: mycn (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: yaf1 (homo sapiens) (aka histone deacetylase 2)
D: yaf5 (saccharomyces cerevisiae s288c) (aka ubiquitin-protein transfe... | [H; A; L] |
<Instruct>: Given the context 'This differential influence on two members of the Myc family gives insight into a new mechanism to modulate the biological activities of Myc transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [myc]
<Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
C: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
... | [E] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: elk1 (bos taurus) (aka ets transcription factor elk1)
B: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: fibroblast growth factor receptor 2 (sus scrofa) (aka fibrobl... | [G; G; G] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: kgfr (homo sapiens) (aka fibroblast growth factor receptor 2)
B: fibroblast growth factor receptor 3 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: bek (xenopus tropicalis) (aka fibroblast growth facto... | [A; A; A] |
<Instruct>: Given the context 'Bacteria expressing the kinase domain of the keratinocyte growth factor receptor (bek/fibroblast growth factor receptor 2) were infected with a fibroblast cDNA library in a phagemid prokaryotic expression vector and screened with a monoclonal anti-phosphotyrosine antibody.', select the co... | <Mentions>: [keratinocyte growth factor receptor; bek; fibroblast growth factor receptor 2]
<Options>: A: hbgfr (homo sapiens) (aka fibroblast growth factor receptor 1)
B: rabepk (bos taurus) (aka rab9 effector protein with kelch motifs)
C: trkb (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
D: fibroblast... | [I; I; I] |
<Instruct>: Given the context 'Both serine and tyrosine phosphatase activities were completely abolished by mutagenesis of a single cysteine residue conserved in VH1 and the VH1-related (VHR) human protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [vh1-related (vhr) human protein]
<Options>: A: vh5 (homo sapiens) (aka immunoglobulin heavy variable 5-78 (pseudogene))
B: hshvrp1 (homo sapiens) (aka transmembrane protein 266)
C: vhnf1 (homo sapiens) (aka hnf1 homeobox b)
D: vhr (homo sapiens) (aka dual specificity phosphatase 3)
E: vho (homo sapiens) (a... | [D] |
<Instruct>: Given the context 'These properties suggest that VHR is capable of regulating intracellular events mediated by both tyrosine and serine phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [vhr]
<Options>: A: hvr1 (homo sapiens) (aka vasoactive intestinal peptide receptor 1)
B: ig heavy chain v region 102-like (rattus norvegicus) (aka ig heavy chain v region 102-like)
C: vhr (homo sapiens) (aka dual specificity phosphatase 3)
D: vhr2 (saccharomyces cerevisiae s288c) (aka vhr2p)
E: vho (homo s... | [C] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
B: arno3 (homo sapiens) (aka cytohesin 3)
C: tango (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclea... | [C; C; J] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
B: arntl (homo sapiens) (aka basic helix-loop-helix arnt like 1)
C: arno3 (homo sapiens) (aka cytohesin 3)
D: aryl hydrocarbon receptor nuclear translocator 2 (homo sapi... | [G; G; H] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor (rattus norvegicus) (aka aryl hydrocarbon receptor)
B: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
C: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
D: aryl hyd... | [C; C; M] |
<Instruct>: Given the context 'Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: ahrr (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome p450 family 1 subfamily a member 1)
B: aryl hydrocarbon receptor nuclear translocator (gallus gallus) (aka aryl hydrocarbon receptor nuclear ... | [J; J; D] |
<Instruct>: Given the context 'The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects.', select the correct biomedical concept for each mention using the p... | <Mentions>: [ah (dioxin) receptor]
<Options>: A: aryl hydrocarbon receptor nuclear translocator (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor nuclear translocator homolog (caenorhabditis elegans) (aka aryl hydrocarbon receptor nuclear translocator homolog)
C: ahr (homo... | [C] |
<Instruct>: Given the context 'The ligand-bound receptor activates Cyp 1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [cyp 1a1]
<Options>: A: cytochrome p450 family 1 subfamily a member 1 (bos taurus) (aka cytochrome p450 family 1 subfamily a member 1)
B: cytochrome p450 1a1 (oryctolagus cuniculus) (aka cytochrome p450 1a1)
C: ahh (homo sapiens) (cytochrome p450 family 1 subfamily a member 1 (homo sapiens)) (aka cytochrome... | [C] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor nuclear translocator 2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
B: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
C: aryl hydrocarbon receptor (rattus norvegic... | [H; H; J] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: arno3 (homo sapiens) (aka cytohesin 3)
B: aryl hydrocarbon receptor (homo sapiens) (aka aryl hydrocarbon receptor)
C: aryl hydrocarbon receptor nuclear translocator (rattus norvegicus) (aka aryl hydrocarbon receptor nuclear translocator)
D:... | [M; M; B] |
<Instruct>: Given the context 'The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ah receptor nuclear translocator; arnt; ah receptor]
<Options>: A: aryl hydrocarbon receptor nuclear translocator 2 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator 2)
B: arno (homo sapiens) (aka cytohesin 2)
C: aryl hydrocarbon receptor (homo sapiens) (aka aryl hydrocarbon receptor)
D: a... | [D; D; K] |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arnt; ah receptor]
<Options>: A: basic helix-loop-helix arnt like 1 (homo sapiens) (aka basic helix-loop-helix arnt like 1)
B: ahrr (homo sapiens) (aryl hydrocarbon receptor repressor (homo sapiens)) (aka aryl hydrocarbon receptor repressor)
C: arnt (drosophila melanogaster) (aka tango)
D: aryl hydrocarbon... | [J; E] |
<Instruct>: Given the context 'Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arnt; ah receptor]
<Options>: A: arnt (homo sapiens) (aryl hydrocarbon receptor nuclear translocator (homo sapiens)) (aka aryl hydrocarbon receptor nuclear translocator)
B: aryl hydrocarbon receptor (bos taurus) (aka aryl hydrocarbon receptor)
C: aryl hydrocarbon receptor nuclear translocator (homo sapiens... | [A; F] |
<Instruct>: Given the context 'Furthermore, Arnt and the ligand-binding subunit of the receptor were extracted as a complex from the nuclei of cells treated with ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [arnt]
<Options>: A: arno (homo sapiens) (aka cytohesin 2)
B: basic helix-loop-helix arnt like 1 (xenopus tropicalis) (aka basic helix-loop-helix arnt like 1)
C: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
D: arntl (homo sapiens) (aka basic helix-loop-helix arnt like 1)
E: arnt... | [C] |
<Instruct>: Given the context 'Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [arnt]
<Options>: A: arntl (homo sapiens) (aka basic helix-loop-helix arnt like 1)
B: arno (homo sapiens) (aka cytohesin 2)
C: arnt1 (homo sapiens) (aka aryl hydrocarbon receptor nuclear translocator)
D: arno3 (homo sapiens) (aka cytohesin 3)
E: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear tra... | [C] |
<Instruct>: Given the context 'Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [arnt]
<Options>: A: arno (homo sapiens) (aka cytohesin 2)
B: arno3 (homo sapiens) (aka cytohesin 3)
C: arnt (mus musculus) (aka aryl hydrocarbon receptor nuclear translocator)
D: arntl (homo sapiens) (aka basic helix-loop-helix arnt like 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [saf-a]
<Options>: A: saf-b (homo sapiens) (aka scaffold attachment factor b)
B: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
C: scf ubiquitin ligase complex subunit saf1 (saccharomyces cerevisiae s288c) (aka scf ubiquitin ligase complex subunit saf1)
D: saf-1 (homo sapiens) (aka myc ... | [B] |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [scaffold attachment region; sar]
<Options>: A: small regulatory polypeptide of amino acid response (sus scrofa) (aka small regulatory polypeptide of amino acid response)
B: clk4-associating serine/arginine rich protein (mus musculus) (aka clk4-associating serine/arginine rich protein)
C: sar (mus musculus)... | [K; K] |
<Instruct>: Given the context 'We identified four proteins in nuclear extracts from HeLa cells which specifically bind to a scaffold attachment region (SAR) element from the human genome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [scaffold attachment region; sar]
<Options>: A: small regulatory polypeptide of amino acid response (sus scrofa) (aka small regulatory polypeptide of amino acid response)
B: receptor associated protein of the synapse (sus scrofa) (aka receptor associated protein of the synapse)
C: scaffold protein involved ... | [K; K] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: chromatin assembly factor 1 subunit a (sus scrofa) (aka chromatin assembly factor 1 subunit a)
B: saf-a2 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u like 2)
C: saf (homo sapiens) (aka fas antisense rna 1)
D: sra (drosophila melanogas... | [L; L; O] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: sarp (homo sapiens) (aka ankyrin repeat domain 42)
B: small regulatory polypeptide of amino acid response (sus scrofa) (aka small regulatory polypeptide of amino acid response)
C: uv stimulated scaffold protein a (sus scrofa) (aka uv stimulated scaffo... | [J; J; O] |
<Instruct>: Given the context 'Of these four proteins, SAF-A (scaffold attachment factor A), shows the highest affinity for several homologous and heterologous SAR elements from vertebrate cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [saf-a; scaffold attachment factor a; sar]
<Options>: A: chromatin assembly factor 1 subunit a (xenopus tropicalis) (aka chromatin assembly factor 1 subunit a)
B: uv stimulated scaffold protein a (sus scrofa) (aka uv stimulated scaffold protein a)
C: uv stimulated scaffold protein a (xenopus tropicalis) (ak... | [G; G; O] |
<Instruct>: Given the context 'SAF-A is an abundant nuclear protein and a constituent of the nuclear matrix and scaffold.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [saf-a]
<Options>: A: saf-a2 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u like 2)
B: saf-a (drosophila melanogaster) (aka uncharacterized protein)
C: saf-b (homo sapiens) (aka scaffold attachment factor b)
D: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
E: saf-1 (homo... | [D] |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept for each menti... | <Mentions>: [saf-a; sar]
<Options>: A: safa (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
B: sra (drosophila melanogaster) (sarah (drosophila melanogaster)) (aka sarah)
C: saf-a2 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u like 2)
D: sarp (homo sapiens) (aka ankyrin repeat domain 42)
... | [A; K] |
<Instruct>: Given the context 'SAF-A binds at multiple sites to the human SAR element; competition studies with synthetic polynucleotides indicate that these sites most probably reside in the multitude of A/T-stretches which are distributed throughout this element.', select the correct biomedical concept for each menti... | <Mentions>: [saf-a; sar]
<Options>: A: sarp (homo sapiens) (aka ankyrin repeat domain 42)
B: small regulatory polypeptide of amino acid response (homo sapiens) (aka small regulatory polypeptide of amino acid response)
C: saf-a2 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u like 2)
D: saraf (homo sapiens... | [J; K] |
<Instruct>: Given the context 'Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.
', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [udp-glcnac:gal beta 1-3-galnac-r (glcnac to galnac) beta 1-6glcnac transferase]
<Options>: A: galnact16 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 16)
B: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: galnt2 (homo sapiens) (aka polypeptide n-acetylgala... | [D] |
<Instruct>: Given the context 'Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.
', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [udp-glcnac:gal beta 1-3-galnac-r (glcnac to galnac) beta 1-6glcnac transferase]
<Options>: A: galnact16 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 16)
B: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: galnact (homo sapiens) (aka beta-1,4-n-acetyl-galac... | [E] |
<Instruct>: Given the context 'A cDNA encoding UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase (EC 2.4.1.102), which forms critical branches in O-glycans, has been isolated by an expression cloning approach using Chinese hamster ovary (CHO) cells.', select the correct biomedical concept fo... | <Mentions>: [udp-glcnac:gal beta 1-3galnac-r (glcnac to galnac) beta 1-6glcnac transferase]
<Options>: A: galnt2 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 2)
B: c2gnt-l (homo sapiens) (aka glucosaminyl (n-acetyl) transferase 1)
C: galnt6 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltran... | [B] |
<Instruct>: Given the context 'Because the antibody used was found to detect most efficiently the oligosaccharide products attached to leukosialin, the CHO cells were also stably transfected with leukosialin cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [leukosialin]
<Options>: A: sialophorin (homo sapiens) (aka sialophorin)
B: leukosialin-like (rattus norvegicus) (aka leukosialin-like)
C: spn (xenopus tropicalis) (sialophorin (xenopus tropicalis)) (aka sialophorin)
D: granulysin (homo sapiens) (aka granulysin)
E: integrin binding sialoprotein (homo sapien... | [A] |
<Instruct>: Given the context 'The expression of the presumed catalytic domain as a fusion protein with the IgG binding domain of protein A enabled us to demonstrate unequivocally that the cDNA encodes the core 2 beta-1,6-N-acetylglucosaminyltransferase, the enzyme responsible for the formation of Gal beta 1-3(GlcNAc b... | <Mentions>: [core 2 beta-1,6-n-acetylglucosaminyltransferase]
<Options>: A: core-2/i-branching beta-1,6-n-acetylglucosaminyltransferase family protein (caenorhabditis elegans) (aka core-2/i-branching beta-1,6-n-acetylglucosaminyltransferase family protein)
B: b3gnt1, beta-1,3-n-acetylgucosaminyltransferase 1, homolog (... | [C] |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterat... | <Mentions>: [tumor necrosis factor-alpha; tnf]
<Options>: A: tnf (homo sapiens) (aka tumor necrosis factor)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: tnfc (homo sapiens) (aka lymphotoxin beta)
D: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
E: tumor necrosis ... | [A; A] |
<Instruct>: Given the context 'Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.
TNF is a proinflammatory cytokine that has pleiotropic effects on cells and tissues, mediated in large part by alterat... | <Mentions>: [tumor necrosis factor-alpha; tnf]
<Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
C: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
D: tumor necrosis factor (xenopus tropicalis) (aka tumor n... | [B; B] |
<Instruct>: Given the context 'We have used the technique of differential hybridization to identify several primary response genes induced by TNF in human umbilical vein endothelial (HUVE) cells, a cell type that is profoundly activated by cytokine treatment.', select the correct biomedical concept for each mention usi... | <Mentions>: [tnf]
<Options>: A: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: lymphotoxin beta (hom... | [C] |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [b94; tnf]
<Options>: A: tnfb (homo sapiens) (aka lymphotoxin alpha)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tnfc (homo sapiens) (aka lymph... | [F; G] |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [b94; tnf]
<Options>: A: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
B: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member 2 pseudogene)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: ly94 (homo sapiens) (aka natural cytotoxicity triggering recep... | [H; J] |
<Instruct>: Given the context 'One of these cDNA, designated B94, detects a rapidly and transiently induced 4-kb transcript in TNF-treated HUVE cells, and this transcript is superinduced in the concomitant presence of cycloheximide.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [b94; tnf]
<Options>: A: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
B: tnfb (homo sapiens) (aka lymphotoxin alpha)
C: p94 (homo sapiens) (aka calpain 3)
D: b94 (homo sapiens) (aka tnf alpha induced protein 2)
E: rp94 (homo sapiens) (aka spermatogenesis associated 7)
F: ly94 (homo sapie... | [D; A] |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-1 beta; b94]
<Options>: A: il-1 (homo sapiens) (aka interleukin 1 beta)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
D: cp94 (homo sapiens) (aka beaded filament structural protein 1)
E: gpr94 (homo sapiens) (aka purinergic recept... | [A; B] |
<Instruct>: Given the context 'Other proinflammatory stimuli including IL-1 beta and LPS are also able to induce B94 mRNA expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-1 beta; b94]
<Options>: A: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
B: b94 (homo sapiens) (aka tnf alpha induced protein 2)
C: il-1 (homo sapiens) (aka interleukin 1 beta)
D: p94 (homo sapiens) (aka calpain 3)
E: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member... | [C; B] |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [tnf; b94]
<Options>: A: b94 (homo sapiens) (aka tnf alpha induced protein 2)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
E: rp94 (homo sapiens) (aka spermatogenesis associated 7)
... | [D; A] |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [tnf; b94]
<Options>: A: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: b94 (homo sapiens) (aka tnf alpha... | [A; E] |
<Instruct>: Given the context 'Nuclear run-on experiments demonstrate that TNF induction of B94 transcript occurs primarily at the level of transcriptional activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [tnf; b94]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
E: natural killer cells antigen cd94 (bo... | [J; C] |
<Instruct>: Given the context 'Further, B94 is shown to be a single copy gene that is evolutionarily conserved.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b94]
<Options>: A: hg94 (homo sapiens) (aka olfactory receptor family 7 subfamily e member 2 pseudogene)
B: rp94 (homo sapiens) (aka spermatogenesis associated 7)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: b94 (homo sapiens) (aka tnf alpha induced protein 2)
E: cp94 (homo sapiens) (aka be... | [D] |
<Instruct>: Given the context 'Developmental regulation occurs most prominently in mouse embryonic liver and kidney, and a second smaller form of B94 transcript is detected in the placenta and testes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [b94]
<Options>: A: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
B: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
C: cp94 (homo sapiens) (aka beaded filament structural protein 1)
D: natural killer cells antigen cd94 (bos taurus) (aka natural killer cells antigen cd94)
E:... | [E] |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [b94; tnf]
<Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: ly94 (homo sapiens) (aka natural cytotoxicity triggering receptor 1)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
E: rp94 (homo sapiens) (aka spe... | [G; J] |
<Instruct>: Given the context 'B94 and other TNF-responsive transcripts are also induced during capillary tube formation suggesting overlap between genes induced by TNF and those induced during angiogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [b94; tnf]
<Options>: A: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
B: rp94 (homo sapiens) (aka spermatogenesis associated 7)
C: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
D: p94 (homo sapiens) (aka calpain 3)
E: lymphotoxin alpha (homo sapiens) (aka lymphotoxin alpha)
F: tnf... | [J; A] |
<Instruct>: Given the context 'Sequence analysis of the B94 cDNA reveals an open reading frame encoding a 73-kDa polypeptide that has no homology to any known protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [b94]
<Options>: A: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
B: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
C: b94 (homo sapiens) (aka tnf alpha induced protein 2)
D: cp94 (homo sapiens) (aka beaded filament structural protein 1)
E: natural killer cells antigen cd94 (bos taurus) (aka ... | [C] |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept for each... | <Mentions>: [b94; tnf]
<Options>: A: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
B: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
C: tnf (homo sapiens) (aka tumor necrosis factor)
D: gpr94 (homo sapiens) (aka purinergic receptor p2y13)
E: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)... | [J; C] |
<Instruct>: Given the context 'Polyclonal antisera directed against the carboxyl-terminal portion of the B94 protein immunoprecipitates a protein of the predicted molecular mass both from COS cells transfected with a B94 expression vector and from TNF-treated HUVE cells.', select the correct biomedical concept for each... | <Mentions>: [b94; tnf]
<Options>: A: b94 (homo sapiens) (aka tnf alpha induced protein 2)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: cd294 (homo sapiens) (aka prostaglandin d2 receptor 2)
D: b94 (mus musculus) (aka tumor necrosis factor, alpha-induced protein 2)
E: cp94 (homo sapiens) (aka beaded fila... | [A; H] |
<Instruct>: Given the context 'A approximately 35-kDa polypeptide with a unique NH2-terminal sequence has been isolated from bovine lung and found to be present on the surface of endothelial cells where it mediates the binding of AGEs (receptor for advanced glycosylation end product or RAGE).', select the correct biome... | <Mentions>: [rage]
<Options>: A: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
B: rage (gallus gallus) (aka mok protein kinase)
C: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
D: rage (rattus norveg... | [E] |
<Instruct>: Given the context 'Using an oligonucleotide probe based on the amino-terminal sequence of RAGE, an apparently full-length cDNA of 1.5 kilobases was isolated from a bovine lung cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [rage]
<Options>: A: rage1 (homo sapiens) (aka mok protein kinase)
B: rage-1 (xenopus tropicalis) (aka mok protein kinase)
C: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
D: rage (homo sapiens) ... | [D] |
<Instruct>: Given the context 'A partial clone encoding the human counterpart of RAGE, isolated from a human lung library, was found to be approximately 90% homologous to the bovine molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [rage]
<Options>: A: rage-1 (xenopus tropicalis) (aka mok protein kinase)
B: rage1 (homo sapiens) (aka mok protein kinase)
C: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
D: rage (bos taurus) (advanced gl... | [C] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: ncam (homo sapiens) (aka neural cell adhesion molecule 1)
B: ncam-l1 (homo sapiens) (aka l1 cell adhesion molecule)
C: en-rage (bos taurus) (aka s100 calcium binding protein a12)
D: muc-15 (homo sapiens) (aka mucin 15, cell surface associated)
E: rage (gallus gallus) (aka ... | [L; I; A] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: muc8 (homo sapiens) (aka mucin 8)
B: mucin-18 (gallus gallus) (aka melanoma cell adhesion molecule)
C: muc18 (homo sapiens) (aka melanoma cell adhesion molecule)
D: ncam (homo sapiens) (aka neural cell adhesion molecule 1)
E: muc16 (homo sapiens) (aka mucin 16, cell surfac... | [I; C; D] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: muc-15 (homo sapiens) (aka mucin 15, cell surface associated)
B: rage (gallus gallus) (aka mok protein kinase)
C: ceacam1 (homo sapiens) (aka cea cell adhesion molecule 1)
D: muc8 (homo sapiens) (aka mucin 8)
E: ncam (neural cell adhesion molecule) homolog (caenorhabditis ... | [O; K; I] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [rage; muc 18; ncam]
<Options>: A: muc8 (homo sapiens) (aka mucin 8)
B: cea cell adhesion molecule 18 (homo sapiens) (aka cea cell adhesion molecule 18)
C: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos taurus)) (aka advanced glycosylation end-product specific receptor)
D: ncam... | [E; I; L] |
<Instruct>: Given the context 'Based on computer analysis of the amino acid sequence of RAGE and comparison with databases, RAGE is a new member of the immunoglobulin superfamily of cell surface molecules and shares significant homology with MUC 18, NCAM, and the cytoplasmic domain of CD20.', select the correct biomedi... | <Mentions>: [cd20]
<Options>: A: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
B: cd20 (bos taurus) (aka membrane spanning 4-domains a1)
C: cd20l2 (homo sapiens) (aka membrane spanning 4-domains a5)
D: cd20 (homo sapiens) (membrane spanning 4-domains a1 (homo sapiens)) (aka membrane spanning 4-domains a1)... | [D] |
<Instruct>: Given the context 'Expression of the RAGE cDNA in 293 cells allowed them to bind 125I-AGE-albumin in a saturable and dose-dependent manner (Kd approximately 100 nM), blocked by antibody to RAGE.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [rage]
<Options>: A: rage (homo sapiens) (advanced glycosylation end-product specific receptor (homo sapiens)) (aka advanced glycosylation end-product specific receptor)
B: ragef (homo sapiens) (aka rap guanine nucleotide exchange factor 2)
C: rage (rattus norvegicus) (advanced glycosylation end product-spe... | [A] |
<Instruct>: Given the context 'Western blots of 293 cells transfected with RAGE cDNA probed with anti-RAGE IgG demonstrated expression of immunoreactive protein compared to its absence in mock-transfected cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [rage]
<Options>: A: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
B: rage (xenopus laevis) (aka mok protein kinase l homeolog)
C: rage (homo sapiens) (advanced glycosylation end-product specific... | [C] |
<Instruct>: Given the context 'These results suggest that RAGE functions as a cell surface receptor for AGEs, which could potentially mediate cellular effects of this class of glycosylated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [rage]
<Options>: A: rage (rattus norvegicus) (advanced glycosylation end product-specific receptor (rattus norvegicus)) (aka advanced glycosylation end product-specific receptor)
B: rage1 (homo sapiens) (aka mok protein kinase)
C: rage (bos taurus) (advanced glycosylation end-product specific receptor (bos... | [D] |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd59; ly-6]
<Options>: A: cd5 molecule (homo sapiens) (aka cd5 molecule)
B: ly5 (homo sapiens) (aka protein tyrosine phosphatase receptor type c)
C: cd52 molecule (homo sapiens) (aka cd52 molecule)
D: slam family member 7 (homo sapiens) (aka slam family member 7)
E: cd51 (homo sapiens) (aka integrin subuni... | [F; K] |
<Instruct>: Given the context 'Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd59; ly-6]
<Options>: A: ly5 (homo sapiens) (aka protein tyrosine phosphatase receptor type c)
B: lymphocyte antigen 6 family member s (homo sapiens) (aka lymphocyte antigen 6 family member s)
C: lymphocyte antigen 6 family member k (homo sapiens) (aka lymphocyte antigen 6 family member k)
D: cd6 molecule... | [I; K] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: minute-like (drosophila melanogaster) (aka minute-like)
B: migration and invasion inhibitory protein (bos taurus) (aka migration and invasion inhibitory protein)
C: serpinh1 (homo sapiens) (aka serpin family h member 1)
D: mir (homo... | [N; N; N; N] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: intercellular adhesion molecule 1-like (bos taurus) (aka intercellular adhesion molecule 1-like)
B: proprotein convertase subtilisin/kexin type 1 inhibitor (homo sapiens) (aka proprotein convertase subtilisin/kexin type 1 inhibitor)... | [J; J; J; J] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
B: serp1 (homo sapiens) (aka stress associated endoplasmic reticulum protein 1)
C: mir (homo sapiens) (myosin regulatory light chain interacting protein (homo sapiens)) (ak... | [K; K; K; K] |
<Instruct>: Given the context 'The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal noctu... | <Mentions>: [cd59; membrane inhibitor of reactive lysis; mirl; protectin]
<Options>: A: bmp and activin membrane bound inhibitor (homo sapiens) (aka bmp and activin membrane bound inhibitor)
B: proprotein convertase subtilisin/kexin type 1 inhibitor (homo sapiens) (aka proprotein convertase subtilisin/kexin type 1 inhi... | [E; E; E; E] |
<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [cd59; ly-6]
<Options>: A: cd5 molecule (homo sapiens) (aka cd5 molecule)
B: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: lymphocyte antigen 6 family member k (homo sapiens) (aka lymphocyte antigen 6 family member k)
D: cd58 (homo sapiens) (aka cd58 molecule)
E: cd52 molecule (homo sap... | [J; K] |
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