instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [brca2-associated factor 35; braf35]
<Options>: A: braf35 (mus musculus) (aka high mobility group 20b)
B: chromosome 6 c1orf35 homolog (xenopus tropicalis) (aka chromosome 6 c1orf35 homolog)
C: braf35 (homo sapiens) (aka high mobility group 20b)
D: acf65 (homo sapiens) (aka apobec1 complementation factor)
E... | [C; C] |
<Instruct>: Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [brca2-associated factor 35; braf35]
<Options>: A: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf proto-oncogene, serine/threonine kinase s homeolog)
B: saga complex associated factor 29 (homo sapiens) (aka saga complex associated factor 29)
C: ... | [C; C] |
<Instruct>: Given the context 'BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [braf35]
<Options>: A: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
B: braf35 (homo sapiens) (aka high mobility group 20b)
C: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))... | [B] |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [brca2; braf35]
<Options>: A: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
B: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
C: palb2 (homo sapiens) (aka partner and localizer of brca2)
D: brca2, dna repair associated (drosophila melanogaster) (aka br... | [B; I] |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [brca2; braf35]
<Options>: A: palb2 (homo sapiens) (aka partner and localizer of brca2)
B: fancb (homo sapiens) (aka fa complementation group b)
C: braf2 (homo sapiens) (aka braf pseudogene 1)
D: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
E: braf transforming gene, related seque... | [H; J] |
<Instruct>: Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [brca2; braf35]
<Options>: A: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
B: fancd2 (homo sapiens) (aka fa complementation group d2)
C: basal cell carcinoma, susceptibility to, 2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
D: braf (homo sapie... | [G; H] |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [braf35; brca2]
<Options>: A: braf35 (homo sapiens) (aka high mobility group 20b)
B: bcc2 (homo sapiens) (aka basal cell carcinoma, susceptibility to, 2)
C: braf35 (mus musculus) (aka high mobility group 20b)
D: brca2 dna repair associated (homo sapiens) (aka brca2 dna repair associated)
E: fancd2 (homo sap... | [A; D] |
<Instruct>: Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [braf35; brca2]
<Options>: A: braf25 (homo sapiens) (aka high mobility group 20b)
B: braf transforming gene, related sequence 1 (mus musculus) (aka braf transforming gene, related sequence 1)
C: braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis)) (aka b-raf pro... | [A; J] |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [brca2; braf35]
<Options>: A: braf25 (homo sapiens) (aka high mobility group 20b)
B: braf35 (mus musculus) (aka high mobility group 20b)
C: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
D: fancd2 (homo sapiens) (aka fa complementation group d2)
E: braf1 (xenopus l... | [G; A] |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [brca2; braf35]
<Options>: A: braf35 (mus musculus) (aka high mobility group 20b)
B: palb2 (homo sapiens) (aka partner and localizer of brca2)
C: braf2 (homo sapiens) (aka braf pseudogene 1)
D: brca2, dna repair associated (drosophila melanogaster) (aka brca2, dna repair associated)
E: basal cell carcinoma,... | [H; I] |
<Instruct>: Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [brca2; braf35]
<Options>: A: braf (homo sapiens) (aka b-raf proto-oncogene, serine/threonine kinase)
B: braf2 (homo sapiens) (aka braf pseudogene 1)
C: braf (mus musculus) (braf transforming gene, related sequence 1 (mus musculus)) (aka braf transforming gene, related sequence 1)
D: basal cell carcinoma, s... | [F; J] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
C: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
D: nkx6.2 (xenopus laevis) (nk6 h... | [J; A; A] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: nkx6-2 (mus musculus) (aka nk6 homeobox 2)
B: gtx (drosophila melanogaster) (aka syntaxin 18)
C: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
D: nkx6-2 (xenopus tropicalis) (aka nk6 homeobox 2)
E: otx5b (xenopus laevi... | [G; A; A] |
<Instruct>: Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.
Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [nkx6b; nkx6-2; gtx]
<Options>: A: trihelix transcription factor gt-1 (glycine max) (aka trihelix transcription factor gt-1)
B: gtx (homo sapiens) (aka nk6 homeobox 2)
C: nkx3b (homo sapiens) (aka nk3 homeobox 2)
D: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobo... | [K; G; G] |
<Instruct>: Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2)
B: nkx3b (homo sapiens) (aka nk3 homeobox 2)
C: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx6a (homo sapiens) (aka nk6 homeobox 1)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog... | [C] |
<Instruct>: Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b]
<Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
B: nkx3b (homo sapiens) (aka nk3 homeobox 2)
C: nkx6a (homo sapiens) (aka nk6 homeobox 1)
D: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2]
<Options>: A: nkx6b (xenopus tropicalis) (aka nk6 homeobox 2)
B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
C: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
D: nkx6.2 (xenopu... | [G; H] |
<Instruct>: Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nkx6b; nkx6-2]
<Options>: A: nkx3b (homo sapiens) (aka nk3 homeobox 2)
B: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
C: nkx6-3 (homo sapiens) (aka nk6 homeobox 3)
D: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
E: nkx6.2 (xenopus tropicalis) (aka nk6 ... | [D; G] |
<Instruct>: Given the context 'Northern blot experiments showed that NKX6B expression is tightly controlled in a tissue-specific fashion with the highest site of expression being the brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [nkx6b]
<Options>: A: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis)) (aka nk6 homeobox 2 s homeolog)
B: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
C: nkx6-2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx6b (xenopus tropicalis) ... | [C] |
<Instruct>: Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [nkx6b]
<Options>: A: nkx6a (homo sapiens) (aka nk6 homeobox 1)
B: nkx3b (homo sapiens) (aka nk3 homeobox 2)
C: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
D: nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis)) (aka nk6 homeobox 2 l homeolog)
E: otx5b (xenopus laevis) (cone-rod homeobox s ho... | [C] |
<Instruct>: Given the context 'These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [nkx6b]
<Options>: A: nkx6a (homo sapiens) (aka nk6 homeobox 1)
B: nkx6.2 (homo sapiens) (aka nk6 homeobox 2)
C: otx5b (xenopus laevis) (cone-rod homeobox s homeolog (xenopus laevis)) (aka cone-rod homeobox s homeolog)
D: nkx3b (homo sapiens) (aka nk3 homeobox 2)
E: nkx6.2 (xenopus laevis) (nk6 homeobox 2 s... | [B] |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd58; cd2]
<Options>: A: cd54 (homo sapiens) (aka intercellular adhesion molecule 1)
B: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
C: cd2 molecule (homo sapiens) (aka cd2 molecule)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: cd2 locus control region (homo sapiens) (aka cd2 locus control... | [F; C] |
<Instruct>: Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd58; cd2]
<Options>: A: cd5 molecule (homo sapiens) (aka cd5 molecule)
B: cd2 (gallus gallus) (aka cd2 molecule)
C: cd57 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
D: cd58 molecule (homo sapiens) (aka cd58 molecule)
E: cd2 molecule (bos taurus) (aka cd2 molecule)
F: cd55 (homo sapiens) (aka cd5... | [D; H] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd58 molecule (homo sapiens) (aka cd58 molecule)
B: cd59 molecule (cd59 blood group) (homo sapiens) (aka cd59 molecule (cd59 blood group))
C: cd22 (homo sapiens) (aka cd22 molecule)
D: integrin subunit beta 4 (homo sapiens) (aka integrin subunit beta 4)
E: nectin-4 (homo sapie... | [M; A; H] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: integrin subunit alpha 4 (homo sapiens) (aka integrin subunit alpha 4)
B: cd2 (gallus gallus) (aka cd2 molecule)
C: cd2 (homo sapiens) (aka cd2 molecule)
D: cd52 (homo sapiens) (aka cd52 molecule)
E: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
F: cd5... | [L; K; C] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: hm4 (homo sapiens) (aka cholinergic receptor muscarinic 4)
C: cd4 molecule (homo sapiens) (aka cd4 molecule)
D: cd22 molecule (homo sapiens) (aka cd22 molecule)
E: cd52 molecule (homo sapiens) (aka cd52 molecule)
F: cd2 (homo sapiens) ... | [C; I; F] |
<Instruct>: Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd4; cd58; cd2]
<Options>: A: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
B: cd2 (homo sapiens) (aka cd2 molecule)
C: cd52 molecule (homo sapiens) (aka cd52 molecule)
D: cd21 (homo sapiens) (aka complement c3d receptor 2)
E: gp4 (homo sapiens) (aka cd36 molecule (cd36 blood group))
F: inte... | [G; O; B] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
B: c-fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
C: juno (homo sapiens) (aka izumo1 receptor, juno)
D: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolo... | [B; M; N] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
B: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
C: fosb proto-oncogene, ap-1 t... | [H; D; N] |
<Instruct>: Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [fos; jun; il-2]
<Options>: A: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
B: interleukin 3 (homo sapiens) (aka interleukin 3)
C: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
D: csf2 (h... | [K; I; H] |
<Instruct>: Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [c-fos]
<Options>: A: c-fos (xenopus tropicalis) (aka fbj murine osteosarcoma viral oncogene homolog)
B: fosl1 (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
C: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subun... | [D] |
<Instruct>: Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [c-fos]
<Options>: A: fosl1 (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
B: c-fos (xenopus tropicalis) (aka fbj murine osteosarcoma viral oncogene homolog)
C: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subun... | [E] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: cd2 (bos taurus) (aka cd2 molecule)
C: cd2 molecule (homo sapiens) (aka cd2 molecule)
D: cd228 (homo sapiens) (aka melanotransferrin)
E: il22 (homo sapiens) (aka interleukin 22)
F: interleukin enhancer binding factor 2 (homo sapiens) (aka i... | [C; I] |
<Instruct>: Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2; il-2]
<Options>: A: cd21 (homo sapiens) (aka complement c3d receptor 2)
B: cd2 (gallus gallus) (aka cd2 molecule)
C: il22 (homo sapiens) (aka interleukin 22)
D: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
E: cd228 (homo sapiens) (aka melanotransferrin)
F: cd2 molecule (homo ... | [F; G] |
<Instruct>: Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [cd2]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd2 (bos taurus) (aka cd2 molecule)
D: cd2 (gallus gallus) (aka cd2 molecule)
E: cd2 (homo sapiens) (aka cd2 molecule)
F: None of the above. | [E] |
<Instruct>: Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
B: cd2 (homo sapiens) (aka cd2 molecule)
C: cd2 (bos taurus) (aka cd2 molecule)
D: cd21 (homo sapiens) (aka complement c3d receptor 2)
E: cd2 (gallus gallus) (aka cd2 molecule)
F: None of the above. | [B] |
<Instruct>: Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd2]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd2 molecule (homo sapiens) (aka cd2 molecule)
D: cd2 (gallus gallus) (aka cd2 molecule)
E: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
F: None of the above. | [C] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: target of rapamycin homolog (caenorhabditis elegans) (aka target of rapamycin homolog)
B: mechanistic target of rapamycin (drosophila melanogaster) (aka mechanistic target of rapamycin)
C: mechanistic target of rapamycin kinase (mus musculus) (aka mechanis... | [H; H] |
<Instruct>: Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mammalian target of rapamycin; mtor]
<Options>: A: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
B: mtor (drosophila melanogaster) (megator (drosophila melanogaster)) (aka megator)
C: mechanistic target of rapamycin kinase (mus musculus) (aka mechanistic target of rapamycin kinase)
D: me... | [I; I] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: protein kinase amp-activated catalytic subunit alpha 1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
B: alpha kinase 2 (homo sapiens) (aka alpha kinase 2)
C: prkar2a (homo sapiens) (aka protein kinase camp-dependent type ii regulatory su... | [K; K] |
<Instruct>: Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [alpha1 ampk; alpha2 ampk]
<Options>: A: protein kinase camp-activated catalytic subunit alpha (homo sapiens) (aka protein kinase camp-activated catalytic subunit alpha)
B: ampkalpha1 (mus musculus) (aka protein kinase, amp-activated, alpha 1 catalytic subunit)
C: ampk alpha 1 (homo sapiens) (aka protein ki... | [J; J] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: s6k2 (homo sapiens) (aka ribosomal protein s6 kinase b2)
B: mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster)) (aka mechanistic target of rapamycin)
C: mechanistic target of rapamycin kin... | [L; L; L] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: p70 s6ka (homo sapiens) (aka ribosomal protein s6 kinase b1)
B: rps6ka1 (homo sapiens) (aka ribosomal protein s6 kinase a1)
C: mechanistic target of rapamycin kinase (homo sapiens) (aka mechanistic target of rapamycin kinase)
D... | [N; N; N] |
<Instruct>: Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and euka... | <Mentions>: [mammalian target of rapamycin; mtor; ribosomal protein s6 kinase]
<Options>: A: mechanistic target of rapamycin kinase (sus scrofa) (aka mechanistic target of rapamycin kinase)
B: mtor (homo sapiens) (aka mechanistic target of rapamycin kinase)
C: ribosomal protein s6 kinase a6 (homo sapiens) (aka ribosoma... | [N; N; N] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
B: eukaryotic translation initiation factor 4e (xenopus laevis) (aka eukaryotic translation initiation factor 4e)
C: eukaryotic translation initiation factor 4e homologou... | [K; K] |
<Instruct>: Given the context 'A reduction in eIF4E associated with eIF4G to 10% of the control value was also noted.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif4e; eif4g]
<Options>: A: eif4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
B: eif4g1 (homo sapiens) (aka eukaryotic translation initiation factor 4 gamma 1)
C: eif4gl (homo sapiens) (aka cwc22 spliceosome associated protein)
D: eif4e (xenopus laevis) (eukaryotic translation initiati... | [K; K] |
<Instruct>: Given the context 'In contrast, eIF2B activity remained unchanged in response to AICAR treatment and therefore would not appear to contribute to the depression in protein synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [eif2b]
<Options>: A: eif2b2 (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit beta)
B: eif2b (drosophila melanogaster) (eukaryotic translation initiation factor 2b subunit beta (drosophila melanogaster)) (aka eukaryotic translation initiation factor 2b subunit beta)
C: eif2b (homo sap... | [E] |
<Instruct>: Given the context 'Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
B: protocadherin 7 (homo sapiens) (aka protocadherin 7)
C: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: protocadherin 1 (homo sapiens) (aka protoc... | [F] |
<Instruct>: Given the context 'The gene was predominantly expressed in liver, kidney and colon tissues, and was thus designated Protocadherin LKC.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
E: protocadherin 12 (homo sapiens) (... | [F] |
<Instruct>: Given the context 'The expression of Protocadherin LKC is markedly reduced in cancers arising from these tissues at both transcriptional and protein levels.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [protocadherin lkc]
<Options>: A: protocadherin 1 (homo sapiens) (aka protocadherin 1)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdh-pc (homo sapiens) (aka protocadherin 11 y-linked)
D: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
E: pcdhg (homo sapiens) (aka protocadh... | [F] |
<Instruct>: Given the context 'To investigate the effects of Protocadherin LKC expression in colon cancer, we introduced the gene into colon cancer cell line HCT116, which does not express this gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: pcdhac (homo sapiens) (aka protocadherin alpha constant)
E: pcdhgc3 (homo sapiens) (aka protocadheri... | [F] |
<Instruct>: Given the context 'Significantly, Protocadherin LKC expression induced contact inhibition of cell proliferation although it did not affect growth rate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh7 (homo sapiens) (aka protocadherin 7)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: pcdhac (homo sapiens) (aka protocadherin alpha constant)
D: protocadherin 10 (homo sapiens) (aka protocadherin 10)
E: pcdhgc3 (homo sapiens) (aka protocadherin gamma su... | [F] |
<Instruct>: Given the context 'When grown to post-confluence in monolayer cells cultures, Protocadherin LKC-expressing HCT116 no longer formed multiple cell layers and showed the typical paving stone morphology of normal epithelial cells.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhac (homo sapiens) (aka protocadherin alpha constant)
B: protocadherin 10 (homo sapiens) (aka protocadherin 10)
C: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
D: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
E: protocadherin 12 (homo sapiens) (aka p... | [F] |
<Instruct>: Given the context 'Furthermore, expression of Protocadherin LKC suppressed tumor formation of HCT116 cells in a nude mouse model.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [protocadherin lkc]
<Options>: A: pcdh7 (homo sapiens) (aka protocadherin 7)
B: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
C: protocadherin 12 (homo sapiens) (aka protocadherin 12)
D: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
E: protocadherin 1 (homo sapiens) (aka protocadherin 1)... | [F] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: mstp105 (homo sapiens) (aka early endosome antigen 1)
B: mast205 (mus musculus) (aka microtubule associated serine/threonine kinase 2)
C: protocadherin 1 (homo sapiens) (aka protocadherin 1)
D: protocadherin ... | [G; G; N] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: pcdhgc (homo sapiens) (aka protocadherin gamma constant)
B: mast205 (homo sapiens) (aka microtubule associated serine/threonine kinase 2)
C: transmembrane protein 205 (mus musculus) (aka transmembrane protein... | [B; B; N] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [hmast205; microtubule-associated serine/threonine kinase-205 kda; protocadherin lkc]
<Options>: A: protocadherin 1 (homo sapiens) (aka protocadherin 1)
B: transmembrane protein 205 (mus musculus) (aka transmembrane protein 205)
C: 205-kda map (drosophila melanogaster) (aka microtubule-associated protein 20... | [K; K; N] |
<Instruct>: Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', select the correct biomedical concept ... | <Mentions>: [protocadherin lkc]
<Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: protocadherin 1 (homo sapiens) (aka protocadherin 1)
C: pcdhgc3 (homo sapiens) (aka protocadherin gamma subfamily c, 3)
D: protocadherin 7 (homo sapiens) (aka protocadherin 7)
E: pcdh-pc (homo sapiens) (aka protocadh... | [F] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: protocadherin 7 (homo sapiens) (aka protocadherin 7)
B: pdzd4 (homo sapiens) (aka pdz domain containing 4)
C: protocadherin 12 (homo sapiens) (aka protocadherin 12)
D: pdz domain containing 9 (homo sapiens) (aka pdz domain containing 9)
E: pcdhac (homo sapiens)... | [K; K] |
<Instruct>: Given the context 'Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [protocadherin lkc; pdz protein]
<Options>: A: pcdhg (homo sapiens) (aka protocadherin gamma cluster)
B: pdz domain-containing protein 9-like (xenopus tropicalis) (aka pdz domain-containing protein 9-like)
C: pdz domain containing 1 (xenopus tropicalis) (aka pdz domain containing 1)
D: pcdh7 (homo sapiens) ... | [K; K] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans) (aka daxx;spx domain-containing protein;uncharacterized protein)
B: histone deacetylase 7 (homo sapiens) (aka histone deacetylase 7)
C: daxx (mus... | [H; E; F] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens)) (aka histone deacetylase 2)
B: daxx-like protein (drosophila melanogaster) (aka daxx-like protein)
C: daxx;spx domain-containing protein;uncharacterized protein (caenorha... | [G; A; H] |
<Instruct>: Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [daxx; histone deacetylase ii; chromatin-associated protein dek]
<Options>: A: daxx (danio rerio) (aka death-domain associated protein)
B: dek (xenopus tropicalis) (aka dek proto-oncogene)
C: dek proto-oncogene (mus musculus) (aka dek proto-oncogene)
D: dek7 (drosophila melanogaster) (aka eph receptor tyros... | [F; L; I] |
<Instruct>: Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [daxx]
<Options>: A: daxx (danio rerio) (aka death-domain associated protein)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx-like protein (drosophila melanogaster) (aka daxx-like protein)
D: daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans) (aka daxx;s... | [B] |
<Instruct>: Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [daxx]
<Options>: A: daxx-like protein (drosophila melanogaster) (aka daxx-like protein)
B: daxx (danio rerio) (aka death-domain associated protein)
C: daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans) (aka daxx;spx domain-containing protein;uncharacterized protein)
D: daxx... | [E] |
<Instruct>: Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [hdaxx]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: daxx (danio rerio) (aka death-domain associated protein)
D: adx (homo sapiens) (aka ferredoxin 1)
E: hyrax (drosophila melanogaster) (aka hyrax)
F: None of the above. | [A] |
<Instruct>: Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', select the correct biomedical concept for each me... | <Mentions>: [hdaxx]
<Options>: A: daxx (xenopus laevis) (aka death-associated protein 6 l homeolog)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (danio rerio) (aka death-domain associated protein)
D: axed on x (drosophila melanogaster) (aka axed on x)
E: adx (homo sapiens) (aka ferredoxin 1)
F: ... | [B] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (xenopus tropicalis) (aka death-associated protein 6)
B: adx (homo sapiens) (aka ferredoxin 1)
C: daxx (homo sapiens) (aka death domain associated protein)
D: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
E: axed on x (drosophila melanoga... | [C; G] |
<Instruct>: Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated prote... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: hyrax (drosophila melanogaster) (aka hyrax)
C: ndaxoa (homo sapiens) (aka succinate dehydrogenase complex flavoprotein subunit a)
D: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
E: ... | [A; E] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: daxx (homo sapiens) (aka death domain associated protein)
B: daxx (danio rerio) (aka death-domain associated protein)
C: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
D: daxx (xenopus tropicalis) (aka death-associated protein 6)
E: histone dea... | [A; H] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: histone deacetylase 3 (homo sapiens) (aka histone deacetylase 3)
B: daxx (drosophila melanogaster) (aka daxx-like protein)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: daxx (homo sapiens) (aka death domain associated protein)
E: histone deacetylase ... | [D; F] |
<Instruct>: Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [hdaxx; histone deacetylase ii]
<Options>: A: histone deacetylase 1 (homo sapiens) (aka histone deacetylase 1)
B: histone deacetylase 2 (mus musculus) (aka histone deacetylase 2)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: axed on x (drosophila melanogaster) (aka axed on x)
E: adx (homo sap... | [I; J] |
<Instruct>: Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [hdaxx]
<Options>: A: adx (homo sapiens) (aka ferredoxin 1)
B: daxx (xenopus tropicalis) (aka death-associated protein 6)
C: axed on x (drosophila melanogaster) (aka axed on x)
D: daxx (drosophila melanogaster) (aka daxx-like protein)
E: daxx (homo sapiens) (aka death domain associated protein)
F: None of t... | [E] |
<Instruct>: Given the context 'A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [hdaxx]
<Options>: A: daxx (danio rerio) (aka death-domain associated protein)
B: daxx (homo sapiens) (aka death domain associated protein)
C: daxx (drosophila melanogaster) (aka daxx-like protein)
D: daxx (xenopus tropicalis) (aka death-associated protein 6)
E: adx (homo sapiens) (aka ferredoxin 1)
F: None... | [B] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: securin (saccharomyces cerevisiae s288c) (aka securin)
B: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
C: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodi... | [B; I] |
<Instruct>: Given the context 'Regulation of human separase by securin binding and autocleavage.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
B: securin (xenopus laevis) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
D... | [I; E] |
<Instruct>: Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: separase (drosophila melanogaster) (aka separase)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: extra spindle pole bodies like 1, separase (bos taurus) (aka... | [A] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: separase (saccharomyces cerevisiae s288c) (aka separase)
C: separase (drosophila melanogaster) (aka separase)
D: extra spindle pole bodies ... | [E; J] |
<Instruct>: Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase; securin]
<Options>: A: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
C: pttg1 ... | [A; B] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [separase]
<Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: homolog of separase (arabidopsis thaliana) (aka separase)
C: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
D: extra spindle pole bodies like... | [C] |
<Instruct>: Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [separase]
<Options>: A: separase (candida albicans sc5314) (aka separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: esp1 (homo sapiens) (extra spindle pole bodies like 1,... | [D] |
<Instruct>: Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [separase]
<Options>: A: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies 1, separase (mus musculus) (aka extra spindle pole bodies 1, separase)
C: separase (saccharomyces cerevisiae s288c) (aka sepa... | [A] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [securin; separase]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
C: extr... | [B; J] |
<Instruct>: Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [securin; separase]
<Options>: A: provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis) (aka provisional ortholog of pttg1 regulator of sister chromatid separation, securin)
B: securin (caenorhabditis elegans) (aka securin)
C: separase (drosophila melanogaster)... | [J; I] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
B: sec62 homolog, preprotein translocation factor s homeolog (xenopus laevis) (aka sec62 homolog, preprotein translocation factor s homeolog)
C: pttg1 regulator ... | [D; F] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [securin; separase]
<Options>: A: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pttg1 regulator of sister chromatid separation, securin)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: esp1 (homo sapiens) (ex... | [J; C] |
<Instruct>: Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [securin; separase]
<Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: separin homolog sep-1 (caenorhabditis elegans) (aka separin homolog sep-1)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka p... | [E; H] |
<Instruct>: Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [securin]
<Options>: A: securin (saccharomyces cerevisiae s288c) (aka securin)
B: securin (oryctolagus cuniculus) (aka securin)
C: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
D: securin (caenorhabditis elegans) (aka sec... | [C] |
<Instruct>: Given the context 'A noncleavable separase mutant retains its ability to cleave cohesin in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: separase (drosophila melanogaster) (aka separase)
B: separase (candida albicans sc5314) (aka separase)
C: separase (saccharomyces cerevisiae s288c) (aka separase)
D: extra spindle pole bodies like 1, separase (bos taurus) (aka extra spindle pole bodies like 1, separase)
E: extra spi... | [E] |
<Instruct>: Given the context 'Our results suggest that separase is required for sister chromatid separation during mitosis in human cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: separase (candida albicans sc5314) (aka separase)
D: homo... | [A] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [securin; separase]
<Options>: A: homolog of separase (arabidopsis thaliana) (aka separase)
B: pttg1 regulator of sister chromatid separation, securin (homo sapiens) (aka pttg1 regulator of sister chromatid separation, securin)
C: pttg1 regulator of sister chromatid separation, securin (danio rerio) (aka pt... | [B; H] |
<Instruct>: Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [securin; separase]
<Options>: A: extra spindle pole bodies like 1, separase (homo sapiens) (aka extra spindle pole bodies like 1, separase)
B: pttg1 regulator of sister chromatid separation, securin (bos taurus) (aka pttg1 regulator of sister chromatid separation, securin)
C: securin (oryctolagus cuniculus... | [E; A] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [securin; separase]
<Options>: A: separase (saccharomyces cerevisiae s288c) (aka separase)
B: extra spindle pole bodies like 1, separase (xenopus tropicalis) (aka extra spindle pole bodies like 1, separase)
C: securin (oryctolagus cuniculus) (aka securin)
D: pttg1 regulator of sister chromatid separation, s... | [E; J] |
<Instruct>: Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [securin; separase]
<Options>: A: esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens)) (aka extra spindle pole bodies like 1, separase)
B: securin-like protein (caenorhabditis elegans) (aka securin-like protein)
C: homolog of separase (arabidopsis thaliana) (aka separase)
D: sec62... | [I; A] |
<Instruct>: Given the context 'Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd3 gamma]
<Options>: A: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
B: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
C: cd3 gamma subunit of t-cell receptor complex (rattus norvegicus) (aka cd3 gamma subunit of t-cell rece... | [D] |
<Instruct>: Given the context 'We report here on the participation of CD3 gamma in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [cd3 gamma]
<Options>: A: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
B: cd3 gamma subunit of t-cell receptor complex (sus scrofa) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo ... | [C] |
<Instruct>: Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, includin... | <Mentions>: [cd3 gamma]
<Options>: A: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
B: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr gamma alternate reading frame protein)
C: cd3 gamma subunit of t-cell receptor com... | [C] |
<Instruct>: Given the context 'In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [icam-1]
<Options>: A: intercellular adhesion molecule 1 (homo sapiens) (aka intercellular adhesion molecule 1)
B: cell adhesion molecule 1 (homo sapiens) (aka cell adhesion molecule 1)
C: cd51 (homo sapiens) (aka integrin subunit alpha v)
D: intercellular adhesion molecule 5 (homo sapiens) (aka intercellul... | [A] |
<Instruct>: Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [cd3 gamma]
<Options>: A: cd3epsilon (homo sapiens) (aka cd3 epsilon subunit of t-cell receptor complex)
B: cd3 gamma subunit of t-cell receptor complex (bos taurus) (aka cd3 gamma subunit of t-cell receptor complex)
C: cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens)) (aka tcr ... | [E] |
<Instruct>: Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adam10; l1 adhesion molecule]
<Options>: A: metalloproteinase adam10-like (xenopus tropicalis) (aka metalloproteinase adam10-like)
B: l1cam (homo sapiens) (aka l1 cell adhesion molecule)
C: adam30 (homo sapiens) (aka adam metallopeptidase domain 30)
D: adam15 (homo sapiens) (aka adam metallopeptidase domai... | [E; B] |
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