instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'The structure of the CD59 gene is very similar to that encoding Ly-6, a murine glycoprotein with which CD59 has some structural similarity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [cd59; ly-6]
<Options>: A: cd55 (homo sapiens) (aka cd55 molecule (cromer blood group))
B: lymphocyte antigen 6 family member h (homo sapiens) (aka lymphocyte antigen 6 family member h)
C: lir-6 (homo sapiens) (aka leukocyte immunoglobulin like receptor a1)
D: cd51 (homo sapiens) (aka integrin subunit alpha... | [J; K] |
<Instruct>: Given the context 'The striking similarity in gene structure is further evidence that the two proteins belong to a superfamily of proteins that may also include the urokinase plasminogen-activator receptor and a squid glycoprotein of unknown function.', select the correct biomedical concept for each mention... | <Mentions>: [urokinase plasminogen-activator receptor]
<Options>: A: urokinase plasminogen activator surface receptor-like (danio rerio) (aka urokinase plasminogen activator surface receptor-like)
B: plasminogen activator, urokinase receptor (xenopus tropicalis) (aka plasminogen activator, urokinase receptor)
C: upar (... | [C] |
<Instruct>: Given the context 'Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-1 receptor antagonist]
<Options>: A: interleukin 1 receptor antagonist (mus musculus) (aka interleukin 1 receptor antagonist)
B: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagonist)
C: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
D: ... | [D] |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical conc... | <Mentions>: [interleukin-1 receptor antagonist; il-1ra]
<Options>: A: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
B: il1rap (homo sapiens) (aka interleukin 1 receptor accessory protein)
C: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagonist)
D: interleukin 36 receptor... | [H; H] |
<Instruct>: Given the context 'By screening a human genomic library with an interleukin-1 receptor antagonist (IL-1ra) cDNA probe, we have isolated a 15 kb clone which contains the entire coding region of the gene as expressed in monocytes, and includes 6 kb of 5'-upstream sequence.', select the correct biomedical conc... | <Mentions>: [interleukin-1 receptor antagonist; il-1ra]
<Options>: A: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
B: interleukin 1 receptor antagonist (mus musculus) (aka interleukin 1 receptor antagonist)
C: interleukin 1 receptor antagonist (rattus norvegicus) (aka interleukin 1 receptor antagon... | [G; G] |
<Instruct>: Given the context 'The gene contains four exons which code for the secreted form of the IL-1ra, however, our clone does not contain the alternative first exon used to generate an intracellular form of the protein as the protein as found in epithelial cells.', select the correct biomedical concept for each m... | <Mentions>: [il-1ra]
<Options>: A: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
B: il1ra (homo sapiens) (interleukin 1 receptor antagonist (homo sapiens)) (aka interleukin 1 receptor antagonist)
C: il11ra (homo sapiens) (aka interleukin 11 receptor subunit alpha)
D: il1rap (homo sapiens) (aka interleu... | [B] |
<Instruct>: Given the context 'By in-situ fluorescence hybridization we have shown that the IL-1ra gene is found on the long arm of chromosome 2 and maps to 2q13-14.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [il-1ra]
<Options>: A: il-1racp (homo sapiens) (aka interleukin 1 receptor accessory protein)
B: il-1r-alpha (homo sapiens) (aka interleukin 1 receptor type 1)
C: il-1rrp (homo sapiens) (aka interleukin 18 receptor 1)
D: il-1ra (homo sapiens) (interleukin 6 receptor (homo sapiens)) (aka interleukin 6 recept... | [E] |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [il-1 alpha; il-1 beta]
<Options>: A: il1beta (homo sapiens) (aka interleukin 1 beta)
B: interferon alpha 1 (homo sapiens) (aka interferon alpha 1)
C: il-1 (homo sapiens) (aka interleukin 1 beta)
D: il-1a (homo sapiens) (aka interleukin 1 alpha)
E: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
F: interle... | [D; A] |
<Instruct>: Given the context 'Previous studies have revealed that IL-1 alpha, and IL-1 beta and both type I and type II forms of the IL-1 receptor all map close to this region of chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [il-1 alpha; il-1 beta]
<Options>: A: il1b (homo sapiens) (aka interleukin 1 beta)
B: ifn1@ (homo sapiens) (aka interferon, type 1, cluster)
C: interferon alpha 1 (homo sapiens) (aka interferon alpha 1)
D: il-1 (homo sapiens) (aka interleukin 1 beta)
E: interleukin 36 beta (homo sapiens) (aka interleukin 36... | [G; A] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: aprataxin-like (arabidopsis thaliana) (aka aprataxin-like protein)
B: etaa1 (homo sapiens) (aka etaa1 activator of atr kinase)
C: epilepsy, occipitotemporal lobe, and migraine with aura (homo sapiens) (aka epil... | [H; H; H] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: aprataxin (homo sapiens) (aka aprataxin)
B: aprataxin (sus scrofa) (aka aprataxin)
C: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
D: aprataxin-like (arabidopsis thali... | [A; A; A] |
<Instruct>: Given the context 'Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is an autosomal recessive neurodegenerative disorder characterized by early-onset ataxia, ocular motor apra... | <Mentions>: [aprataxin; eaoh; early-onset ataxia with ocular motor apraxia and hypoalbuminemia]
<Options>: A: eaa1 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 4)
B: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
C: aprataxin (mus musculus) (aka aprata... | [M; M; M] |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaoh; aptx]
<Options>: A: aptx (drosophila melanogaster) (aka aprataxin)
B: eay (drosophila melanogaster) (eyes absent (drosophila melanogaster)) (aka eyes absent)
C: eoaha (homo sapiens) (aka aprataxin)
D: aptx (arabidopsis thaliana) (aka aprataxin-like protein)
E: aptx (mus musculus) (aka aprataxin)
F: e... | [C; C] |
<Instruct>: Given the context 'Recently, the causative gene for EAOH, APTX, has been identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaoh; aptx]
<Options>: A: hae (arabidopsis thaliana) (aka leucine-rich receptor-like protein kinase family protein)
B: etaa1 (homo sapiens) (aka etaa1 activator of atr kinase)
C: eay (drosophila melanogaster) (early (drosophila melanogaster)) (aka early)
D: apt1 (xenopus laevis) (fas cell surface death rec... | [F; F] |
<Instruct>: Given the context 'Of the two splicing variants of APTX mRNA, the short and the long forms, long-form APTX mRNA was found to be the major isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [aptx]
<Options>: A: aptx (drosophila melanogaster) (aka aprataxin)
B: aptx (homo sapiens) (aka aprataxin)
C: aptr (homo sapiens) (aka alu-mediated cdkn1a/p21 transcriptional regulator)
D: apt1 (xenopus laevis) (fas cell surface death receptor s homeolog (xenopus laevis)) (aka fas cell surface death recepto... | [B] |
<Instruct>: Given the context 'Aprataxin is mainly located in the nucleus, and, furthermore, the first nuclear localization signal located near the amino terminus of the long-form aprataxin is essential for its nuclear localization.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [aprataxin]
<Options>: A: aprataxin (drosophila melanogaster) (aka aprataxin)
B: aprataxin-like protein (arabidopsis thaliana) (aka aprataxin-like protein)
C: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
D: aprataxin (xenopus tropicalis) (aka aprataxin)
E: aprataxin (homo sapiens) (aka a... | [E] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: xrcc1 (homo sapiens) (aka x-ray repair cross complementing 1)
B: aprataxin (mus musculus) (aka aprataxin)
C: xrcc11 (homo sapiens) (aka brca2 dna repair associated)
D: aprataxin (sus scrofa) (aka aprataxin)
E: homolog of x-ray repair... | [L; A; A] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
B: x-ray repair cross complementing 1 (sus scrofa) (aka x-ray repair cross complementing 1)
C: xrcc9 (homo sapiens) (aka fa complementation grou... | [L; K; K] |
<Instruct>: Given the context 'We found, based on the yeast two-hybrid and coimmunoprecipitation experiments, that the long-form but not the short-form aprataxin interacts with XRCC1 (x-ray repair cross-complementing group 1).', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [aprataxin; xrcc1; x-ray repair cross-complementing group 1]
<Options>: A: aprataxin-like protein (arabidopsis thaliana) (aka aprataxin-like protein)
B: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
C: xrcc1 (xenopus laevis) (x-ray repair complementing defective re... | [G; L; L] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: dna polymerase beta (homo sapiens) (aka dna polymerase beta)
B: aprataxin l homeolog (xenopus laevis) (aka aprataxin l homeolog)
C: polynucleotide kinase 3'-phosphatase (xenopus tropicalis) (aka polynucleotide kinase ... | [O; N; D; A] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
B: polymerase (dna directed), beta (xenopus tropicalis) (aka polymerase (dna directed), beta)
C: xrcc1 (oryctolagus cuniculus) (... | [P; S; O; M] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: aprataxin (mus musculus) (aka aprataxin)
B: xrcc1 (oryctolagus cuniculus) (aka x-ray repair cross complementing 1)
C: pnk (homo sapiens) (polynucleotide kinase 3'-phosphatase (homo sapiens)) (aka polynucleotide kinase... | [J; C; K; G] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [aprataxin; polynucleotidekinase-3'-phosphatase; xrcc1; dna polymerase beta]
<Options>: A: dna polymerase beta (homo sapiens) (aka dna polymerase beta)
B: aprataxin (sus scrofa) (aka aprataxin)
C: dna polymerase iota (homo sapiens) (aka dna polymerase iota)
D: xrcc1 (oryctolagus cuniculus) (aka x-ray repair... | [J; P; K; A] |
<Instruct>: Given the context 'Interestingly the amino terminus of the long-form aprataxin is homologous with polynucleotidekinase-3'-phosphatase, which has been demonstrated to be involved in base excision repair, a subtype of single-strand DNA break repair, through interaction with XRCC1, DNA polymerase beta, and DNA... | <Mentions>: [dna ligase iii]
<Options>: A: ligase i, dna, atp-dependent (xenopus tropicalis) (aka ligase i, dna, atp-dependent)
B: dna ligase 1 (homo sapiens) (aka dna ligase 1)
C: ligase iii, dna, atp-dependent (xenopus tropicalis) (aka ligase iii, dna, atp-dependent)
D: lig3 (homo sapiens) (dna ligase 3 (homo sapiens... | [D] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: xrcc1 (xenopus tropicalis) (regulator of chromosome condensation 1 (xenopus tropicalis)) (aka regulator of chromosome condensation 1)
B: aprataxin (drosophila melanogaster) (aka aprataxin)
C: aprataxin (mus musculus) (aka aprataxin)
D: yhae (escherichia coli str. k-12 ... | [L; M; L] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 l homeolog (xenopus laevis)) (aka regulator of chromosome condensation 1 l homeolog)
B: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 s homeolog (xenopus laevis)) (aka regulator of chromoso... | [L; I; L] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: aprataxin-like (xenopus laevis) (aka aprataxin-like)
B: aprataxin and pnkp like factor (xenopus tropicalis) (aka aprataxin and pnkp like factor)
C: xrcc1 (xenopus laevis) (regulator of chromosome condensation 1 l homeolog (xenopus laevis)) (aka regulator of chromosome ... | [F; N; F] |
<Instruct>: Given the context 'These results strongly support the possibility that aprataxin and XRCC1 constitute a multiprotein complex and are involved in single-strand DNA break repair, and furthermore, that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH.', select the corr... | <Mentions>: [aprataxin; xrcc1; eaoh]
<Options>: A: xrcc1 (xenopus laevis) (x-ray repair complementing defective repair in chinese hamster cells 1 l homeolog (xenopus laevis)) (aka x-ray repair complementing defective repair in chinese hamster cells 1 l homeolog)
B: xrcc1 (xenopus tropicalis) (regulator of chromosome co... | [I; C; I] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: cytochrome c, testis-specific (oryctolagus cuniculus) (aka cytochrome c, testis-specific)
B: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
C: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
D: cytochrome c, som... | [B; D; K] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: caspase-9 (xenopus tropicalis) (aka caspase 9)
B: succinate dehydrogenase complex subunit c (homo sapiens) (aka succinate dehydrogenase complex subunit c)
C: casp7 (homo sapiens) (aka caspase 7)
D: casp-8 (homo sapiens) (aka caspase 8)
E: mitochondrially encod... | [H; F; K] |
<Instruct>: Given the context 'Analysis of APAF-1 expression in human cutaneous melanoma progression.
APAF-1 plays a pivotal role in mitochondria-dependent apoptosis, binding to cytochrome c and favoring activation of caspase-9.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [apaf-1; cytochrome c; caspase-9]
<Options>: A: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
B: uqcc (homo sapiens) (aka ubiquinol-cytochrome c reductase complex assembly factor 1)
C: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating fact... | [C; K; J] |
<Instruct>: Given the context 'It has been shown that epigenetic silencing of the APAF-1 gene is a common event in several metastatic melanoma cells in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [apaf-1]
<Options>: A: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
C: apa1 (homo sapiens) (aka zinc finger protein 410)
D: apaf3 (homo sapiens) (aka caspase 9)
E: apak (homo sapiens) (aka zinc finger prote... | [A] |
<Instruct>: Given the context 'We determined, by Western blot, variation in the level of expression of APAF-1 in several human melanoma cell lines and, by immunohistochemistry, in a group of 106 histological samples including benign and malignant melanocytic lesions.', select the correct biomedical concept for each men... | <Mentions>: [apaf-1]
<Options>: A: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
B: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
C: apaf-3 (homo sapiens) (aka caspase 9)
D: apa1 (homo sapiens) (aka zinc finger protein 410)
E: apaf-1 (xenopus tropicalis) (aka apoptoti... | [B] |
<Instruct>: Given the context 'We observed APAF-1 down-regulation or loss of expression in two metastatic melanoma cell lines, compared to primary melanoma cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [apaf-1]
<Options>: A: apa1 (homo sapiens) (aka zinc finger protein 410)
B: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
C: apak (homo sapiens) (aka zinc finger protein 420)
D: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
E: apoptotic peptidase ac... | [E] |
<Instruct>: Given the context 'The immunohistochemical analysis revealed a significant difference in APAF-1 staining between nevi and melanomas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apaf-1]
<Options>: A: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apak (homo sapiens) (aka zinc finger protein 420)
C: apaf3 (homo sapiens) (aka caspase 9)
D: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
E: apaf-1 (dro... | [A] |
<Instruct>: Given the context 'In addition, we found a significant negative correlation between APAF-1 expression level and tumor thickness and between primary melanomas and metastases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [apaf-1]
<Options>: A: apoptotic peptidase activating factor 1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
B: apaf-1 (drosophila melanogaster) (aka death-associated apaf1-related killer)
C: apaf-3 (homo sapiens) (aka caspase 9)
D: apa1 (homo sapiens) (aka zinc finger protein 410)
E: apak (h... | [A] |
<Instruct>: Given the context 'We conclude that loss of APAF-1 expression can be considered as an indicator of malignant transformation in melanoma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apaf-1]
<Options>: A: apa1 (homo sapiens) (aka zinc finger protein 410)
B: apaf1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
C: apaf-1 (xenopus tropicalis) (aka apoptotic peptidase activating factor 1)
D: apak (homo sapiens) (aka zinc finger protein 420)
E: apaf3 (homo sapiens) (aka caspas... | [B] |
<Instruct>: Given the context 'A human cDNA was cloned that encodes a DNA-binding protein (SATB1) that is expressed predominantly in thymus and binds selectively to the nuclear matrix/scaffold-associating DNAs (MARs/SARs).', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [satb1]
<Options>: A: satb1 (sus scrofa) (aka satb homeobox 1)
B: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
C: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
D: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
E: satb1 (rattus norvegicus) (aka satb homeobox 1)
... | [D] |
<Instruct>: Given the context 'Missing nucleoside experiments showed that SATB1 selectively binds in a special AT-rich sequence context where one strand consists of mixed A's, T's, and C's, excluding G's (ATC sequences).', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [satb1]
<Options>: A: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
B: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
C: satb1 (sus scrofa) (aka satb homeobox 1)
D: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
E: sat1 (bos taurus) (aka spermidine/... | [B] |
<Instruct>: Given the context 'Missing nucleoside experiments showed that SATB1 selectively binds in a special AT-rich sequence context where one strand consists of mixed A's, T's, and C's, excluding G's (ATC sequences).', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [satb1]
<Options>: A: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
B: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
C: satb1 (sus scrofa) (aka satb homeobox 1)
D: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'When this feature is destroyed by mutation, SATB1 binding is greatly reduced even if the direct contact sequence remains intact.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [satb1]
<Options>: A: satb1 (rattus norvegicus) (aka satb homeobox 1)
B: sat2 (bos taurus) (aka spermidine/spermine n1-acetyltransferase family member 2)
C: satb1 (homo sapiens) (aka satb homeobox 1)
D: satb2 (bos taurus) (aka satb homeobox 2)
E: satb1 (bos taurus) (aka satb homeobox 1)
F: None of the above... | [C] |
<Instruct>: Given the context 'Conjunctional SATB1-binding sequences become stably unpaired in supercoiled DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb2 (bos taurus) (aka satb homeobox 2)
B: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
C: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
D: satb1 (sus scrofa) (aka satb homeobox 1)
E: satb1 (rattus norvegicus) (aka satb homeobox 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Specific mutations that diminish the unwinding potential greatly reduce SATB1 binding.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 (rattus norvegicus) (aka satb homeobox 1)
B: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
C: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
D: satb2 (bos taurus) (aka satb homeobox 2)
E: satb homeobox 1 (homo sapiens) (aka satb homeobox 1)
F: None of the a... | [E] |
<Instruct>: Given the context 'However, SATB1 does not bind single-stranded DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 (homo sapiens) (aka satb homeobox 1)
B: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
C: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
D: satb1 (sus scrofa) (aka satb homeobox 1)
E: satb2 (bos taurus) (aka satb homeobox 2)
F: None of the ab... | [A] |
<Instruct>: Given the context 'Chemical interference assays show that SATB1 binds along the minor groove with very little contact with the bases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [satb1]
<Options>: A: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
B: satb homeobox 1 (bos taurus) (aka satb homeobox 1)
C: satb1 (sus scrofa) (aka satb homeobox 1)
D: sat1 (bos taurus) (aka spermidine/spermine n1-acetyltransferase 1)
E: satb1 (homo sapiens) (aka satb homeobox 1)
F: None... | [E] |
<Instruct>: Given the context 'This suggests that SATB1 recognizes the ATC sequence indirectly through the altered sugar-phosphate backbone structure present in the double-stranded DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [satb1]
<Options>: A: satb1 (homo sapiens) (aka satb homeobox 1)
B: satb1 antisense rna 1 (homo sapiens) (aka satb1 antisense rna 1)
C: satb1 (bos taurus) (aka satb homeobox 1)
D: satb1 (sus scrofa) (aka satb homeobox 1)
E: satb1 (rattus norvegicus) (aka satb homeobox 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Cloning and characterization of a human angiotensin II type 1 receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [angiotensin ii type 1 receptor]
<Options>: A: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
B: at1br (homo sapiens) (aka angiotensin ii receptor type 1)
C: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
D: angiotensi... | [B] |
<Instruct>: Given the context 'A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 angiotensin ii receptor]
<Options>: A: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
B: agtr1 (homo sapiens) (aka angiotensin ii receptor type 1)
C: angiotensin ii receptor, type 1b (rattus norvegicus) (aka angiotensin ii receptor, type 1b)
D: angiotensi... | [A] |
<Instruct>: Given the context 'Ligand binding studies of the cloned receptor expressed in COS cells suggested that it is pharmacologically a type 1 angiotensin II receptor subtype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [type 1 angiotensin ii receptor]
<Options>: A: angiotensin ii receptor, type 1a (rattus norvegicus) (aka angiotensin ii receptor, type 1a)
B: angiotensin ii receptor type 2 (homo sapiens) (aka angiotensin ii receptor type 2)
C: at1r (homo sapiens) (aka angiotensin ii receptor type 1)
D: angiotensin ii recep... | [C] |
<Instruct>: Given the context 'A gene encoding a putative human RNA helicase, p54, has been cloned and mapped to the band q23.3 of chromosome 11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p54]
<Options>: A: t54 (homo sapiens) (aka g-patch domain and kow motifs)
B: p104 (homo sapiens) (aka natural killer cell triggering receptor)
C: p54h (xenopus tropicalis) (aka dead-box helicase 6)
D: p54a (homo sapiens) (aka mitogen-activated protein kinase 9)
E: d54 (homo sapiens) (aka tpd52 like 2)
F: N... | [F] |
<Instruct>: Given the context 'The predicted amino acid sequence shares a striking homology (75% identical) with the female germline-specific RNA helicase ME31B gene of Drosophila.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [me31b]
<Options>: A: ces31l (mus musculus) (aka carboxylesterase 3b)
B: krt33b (mus musculus) (aka keratin 33b)
C: maternal expression at 31b (drosophila melanogaster) (aka maternal expression at 31b)
D: tmem132b (mus musculus) (aka transmembrane protein 132b)
E: me31b (xenopus tropicalis) (aka dead-box he... | [C] |
<Instruct>: Given the context 'Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.', select the correct biomedical concept for each mention using th... | <Mentions>: [me31b]
<Options>: A: mg33b (mus musculus) (aka transmembrane protein 38b)
B: maternal expression at 31b (drosophila melanogaster) (aka maternal expression at 31b)
C: me31b (xenopus tropicalis) (aka dead-box helicase 6)
D: sec31 homolog b, copii coat complex component (mus musculus) (aka sec31 homolog b, co... | [B] |
<Instruct>: Given the context 'Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [n-myc]
<Options>: A: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
B: n-myc (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcriptio... | [A] |
<Instruct>: Given the context 'The gene termed heir-1 was localized to the neuroblastoma consensus deletion at 1p36.2-p36.12.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heir-1]
<Options>: A: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
B: heir-1 (xenopus laevis) (inhibitor of dna binding 3, hlh protein l homeolog (xenopus laevis)) (aka inhibitor of dna binding 3, hlh protein l homeolog)
C: hin-1 (homo sapiens) (aka secretoglobin family 3a ... | [D] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: emc3 (mus musculus) (aka er membrane protein complex subunit 3)
B: lethal (1) hm442 (drosophila melanogaster) (aka lethal (1) hm442)
C: hlh462 (mus musculus) (aka inhibitor of dna binding 3)
D: lethal (1) hm452 (drosophila melanogaster) (aka lethal (1) hm452)
E: ids (homo sap... | [C; K; H] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: er membrane complex subunit emc3 (saccharomyces cerevisiae s288c) (aka er membrane complex subunit emc3)
B: hlh462 (mus musculus) (aka inhibitor of dna binding 3)
C: id (mus musculus) (aka atpase, class i, type 8b, member 2)
D: lethal (1) hm452 (drosophila melanogaster) (aka ... | [B; C; G] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: iddmx (homo sapiens) (aka diabetes mellitus, insulin-dependent, x-linked, susceptibility to)
B: id (homo sapiens) (aka inhibitor of dna binding 1)
C: zfp462 (xenopus laevis) (zinc finger protein 462 s homeolog (xenopus laevis)) (aka zinc finger protein 462 s homeolog)
D: ids ... | [M; O; E] |
<Instruct>: Given the context 'Its predicted protein is 95.8% identical to the mouse HLH462 protein and has clear homology to the mouse Id and Drosophila emc proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [hlh462; id; emc]
<Options>: A: id (mus musculus) (aka atpase, class i, type 8b, member 2)
B: iddhisd (homo sapiens) (aka transportin 2)
C: lethal (1) hm452 (drosophila melanogaster) (aka lethal (1) hm452)
D: lethal (1) g0462 (drosophila melanogaster) (aka lethal (1) g0462)
E: hlh462 (mus musculus) (aka inh... | [E; A; F] |
<Instruct>: Given the context 'Heir-1 does not encode a basic DNA binding domain as found in basic HLH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heir-1]
<Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: heed (homo sapiens) (aka embryonic ectoderm development)
C: he1 (homo sapiens) (aka npc intracellular cholesterol transporter 2)
D: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
E: heew1 (homo sa... | [A] |
<Instruct>: Given the context 'Despite prominent heir-1 expression in adrenal medulla, which is a prime target for neuroblastomas, 10 out of 12 neuroblastoma-derived cell lines revealed very low levels of heir-1 mRNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [heir-1]
<Options>: A: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
B: heip1 (homo sapiens) (aka regulator of dna class i crossover intermediates 1)
C: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
D: he1 (homo sapiens) (aka npc intracellular cholesterol transporter 2)
E: heir-1 (xenopus laevi... | [C] |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [heir-1; n-myc]
<Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: mycn proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc a... | [A; B] |
<Instruct>: Given the context 'Low heir-1 expression was generally found in tumor cell lines with N-myc overexpression, whereas the two cell lines displaying high heir-1 levels did not overexpress N-myc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [heir-1; n-myc]
<Options>: A: nmyc (homo sapiens) (aka mycn proto-oncogene, bhlh transcription factor)
B: heil1 (homo sapiens) (aka zbtb7c antisense rna 2)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, n... | [G; A] |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [heir-1; n-myc]
<Options>: A: heir-1 (homo sapiens) (aka inhibitor of dna binding 3)
B: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncoge... | [A; I] |
<Instruct>: Given the context 'We conclude that heir-1 expression is reduced specifically in the majority of neuroblastomas and suggest an inverse correlation between heir-1 and N-myc expression in neuroblastoma tumors and in embryonic development.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [heir-1; n-myc]
<Options>: A: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
B: v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog)
C: mycn pro... | [D; C] |
<Instruct>: Given the context 'Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
B: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
C: heterogeneous nuclear ribonucleoprotein u (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u... | [E] |
<Instruct>: Given the context 'The hnRNP U protein is an abundant nucleoplasmic phosphoprotein that is the largest of the major hnRNP proteins (120 kDa by SDS-PAGE).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
B: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpu (xenopus tropicalis) (aka heterogeneous nuclear ribonucleoprotein u (scaffold attachment factor a))
D: hnrnpu (bos t... | [E] |
<Instruct>: Given the context 'HnRNP U binds pre-mRNA in vivo and binds both RNA and ssDNA in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
C: hnrnpu (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u)
D: hnrnpu (mus musculus) (aka heterogeneous nuclear rib... | [C] |
<Instruct>: Given the context 'Here we describe the cloning and sequencing of a cDNA encoding the hnRNP U protein, the determination of its amino acid sequence and the delineation of a region in this protein that confers RNA binding.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
B: heterogeneous nuclear ribonucleoprotein u (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
C: heterogeneous nuclear ribonucleoprotein u (bos taurus) (aka heterogeneous nuclear ribonu... | [E] |
<Instruct>: Given the context 'The predicted amino acid sequence of hnRNP U contains 806 amino acids (88,939 Daltons), and shows no extensive homology to any known proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hnrnp u]
<Options>: A: hnrnpu (mus musculus) (aka heterogeneous nuclear ribonucleoprotein u)
B: hnrnpu (bos taurus) (aka heterogeneous nuclear ribonucleoprotein u)
C: hnrnpup1 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein u pseudogene 1)
D: hnrnpu (xenopus tropicalis) (aka heterogeneous nucle... | [E] |
<Instruct>: Given the context 'Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [cytoskeletal protein 4.1]
<Options>: A: erythrocyte membrane protein band 4.1 like 1 (bos taurus) (aka erythrocyte membrane protein band 4.1 like 1)
B: erythrocyte membrane protein band 4.1 like 4a (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 4a)
C: erythrocyte membrane protein band 4.1 (... | [D] |
<Instruct>: Given the context 'We screened human megakaryoblastic cell line (MEG-01) an umbilical vein endothelial cell cDNA libraries to obtain a 3.7-kilobase cDNA designated PTPase MEG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [ptpase meg]
<Options>: A: ptpmeg1 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 4)
B: phosphoglycolate phosphatase (mus musculus) (aka phosphoglycolate phosphatase)
C: ptpe (mus musculus) (aka protein tyrosine phosphatase receptor type e)
D: meg (drosophila melanogaster) (protein tyros... | [A] |
<Instruct>: Given the context 'We screened human megakaryoblastic cell line (MEG-01) an umbilical vein endothelial cell cDNA libraries to obtain a 3.7-kilobase cDNA designated PTPase MEG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [ptpase meg]
<Options>: A: meg (drosophila melanogaster) (protein tyrosine phosphatase meg (drosophila melanogaster)) (aka protein tyrosine phosphatase meg)
B: ptpe (mus musculus) (aka protein tyrosine phosphatase receptor type e)
C: ptpmeg (mus musculus) (aka protein tyrosine phosphatase, non-receptor type... | [E] |
<Instruct>: Given the context 'PTPase MEG cDNA contains an open reading frame of 926 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ptpase meg]
<Options>: A: ptpmeg (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 4)
B: ptpe (mus musculus) (aka protein tyrosine phosphatase receptor type e)
C: ptpmeg (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 4)
D: meg (drosophila melanogaster) (protein tyrosin... | [C] |
<Instruct>: Given the context 'The amino-terminal region (amino acids 31-367) is 45% identical to the amino terminus of human erythrocyte protein 4.1, a cytoskeletal protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [erythrocyte protein 4.1]
<Options>: A: erythrocyte membrane protein band 4.1 like 4a (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 4a)
B: erythrocyte membrane protein band 4.2 (homo sapiens) (aka erythrocyte membrane protein band 4.2)
C: erythrocyte membrane protein band 4.1 (homo sapiens)... | [C] |
<Instruct>: Given the context 'The receptor for ciliary neurotrophic factor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor]
<Options>: A: ciliary neurotrophic factor receptor (sus scrofa) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (bos taurus) (aka ciliary neurotrophic factor receptor)
C: ciliary neurotrophic factor receptor (xenopus tropicalis) (... | [D] |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor; cntf]
<Options>: A: ciliary neurotrophic factor receptor (mus musculus) (aka ciliary neurotrophic factor receptor)
B: cntfr (homo sapiens) (aka ciliary neurotrophic factor receptor)
C: cntf (homo sapiens) (aka ciliary neurotrophic factor)
D: cntf (xenopus tropicali... | [G; C] |
<Instruct>: Given the context 'A " tagged-ligand panning " procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [receptor for ciliary neurotrophic factor; cntf]
<Options>: A: ciliary neurotrophic factor receptor (bos taurus) (aka ciliary neurotrophic factor receptor)
B: ciliary neurotrophic factor receptor (homo sapiens) (aka ciliary neurotrophic factor receptor)
C: cntn1 (homo sapiens) (aka contactin 1)
D: cntfr (ho... | [B; F] |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [cntf receptor; interleukin-6]
<Options>: A: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
B: cdf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
C: cntfr-alpha (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
D: ciliary neurotrophic factor receptor (homo sapiens) (aka ci... | [D; B] |
<Instruct>: Given the context 'The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [cntf receptor; interleukin-6]
<Options>: A: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
B: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
C: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
D: npffr1 (rattus norvegicus) (aka neuropeptide ff ... | [I; H] |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [cntf receptor; interleukin-6 receptor]
<Options>: A: interleukin 6 cytokine family signal transducer (homo sapiens) (aka interleukin 6 cytokine family signal transducer)
B: cntfr (rattus norvegicus) (aka ciliary neurotrophic factor receptor)
C: cntfr (homo sapiens) (aka ciliary neurotrophic factor receptor... | [C; H] |
<Instruct>: Given the context 'This similarity suggestes that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [cntf receptor; interleukin-6 receptor]
<Options>: A: interleukin 6 cytokine family signal transducer (homo sapiens) (aka interleukin 6 cytokine family signal transducer)
B: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
C: ciliary neurotrophic factor receptor (danio rerio) (aka ciliary neurotrophic fact... | [D; F] |
<Instruct>: Given the context 'In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [cntf receptor]
<Options>: A: ntn1r1 (homo sapiens) (aka dcc netrin 1 receptor)
B: ciliary neurotrophic factor receptor (xenopus tropicalis) (aka ciliary neurotrophic factor receptor)
C: npffr1 (rattus norvegicus) (aka neuropeptide ff receptor 1)
D: cntfr (homo sapiens) (aka ciliary neurotrophic factor rece... | [D] |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cellular retinol-binding protein type ii; rxr]
<Options>: A: rxrbeta (homo sapiens) (aka retinoid x receptor beta)
B: rxr-alpha (homo sapiens) (aka retinoid x receptor alpha)
C: retinol binding protein 2 (homo sapiens) (aka retinol binding protein 2)
D: retinol binding protein 2 (xenopus tropicalis) (aka r... | [C; B] |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cellular retinol-binding protein type ii; rxr]
<Options>: A: retinol binding protein 3 (homo sapiens) (aka retinol binding protein 3)
B: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
C: nr1h2 (homo sapiens) (aka nuclear rece... | [I; D] |
<Instruct>: Given the context 'A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cellular retinol-binding protein type ii; rxr]
<Options>: A: retinol binding protein 2 (xenopus tropicalis) (aka retinol binding protein 2)
B: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
C: rxrc (homo sapiens) (aka retinoi... | [I; J] |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [retinoid x receptor; rxr]
<Options>: A: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
B: lxra (homo sapiens) (aka nuclear receptor subfamily 1 group h member 3)
C: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
D: retinoid x receptor beta (homo sapiens) (aka retinoid x re... | [I; I] |
<Instruct>: Given the context 'The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [retinoid x receptor; rxr]
<Options>: A: retinoid x receptor alpha (homo sapiens) (aka retinoid x receptor alpha)
B: lxra (homo sapiens) (aka nuclear receptor subfamily 1 group h member 3)
C: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
D: retinoid x receptor beta (homo sapiens) ... | [A; A] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: retinol binding protein 2 (xenopus tropicalis) (aka retinol binding protein 2)
B: rxrb (homo sapiens) (aka retinoid x receptor beta)
C: crbpiii (homo sapiens) (aka retinol binding protein 5)
D: crbpi (homo sapiens) (aka retinol binding pr... | [H; H; M] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: crbpiii (homo sapiens) (aka retinol binding protein 5)
B: retinol binding protein 7 (homo sapiens) (aka retinol binding protein 7)
C: retinol binding protein 3 (homo sapiens) (aka retinol binding protein 3)
D: rxr-alpha (homo sapiens) (ak... | [J; J; D] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
B: retinol binding protein 2 (homo sapiens) (aka retinol binding protein 2)
C: rxrc (homo sapiens) (aka retinoid x receptor gamma)
D: nr1h2 (homo sapiens) (aka nuclear receptor subfam... | [B; B; M] |
<Instruct>: Given the context 'We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR.', select the correct biomedical concept for eac... | <Mentions>: [cellular retinol-binding protein type ii; crbpii; rxr]
<Options>: A: crbp-iii (homo sapiens) (aka retinol binding protein 5)
B: retinol binding protein 7 (homo sapiens) (aka retinol binding protein 7)
C: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
D: rxrg (homo sapiens) (aka re... | [H; H; M] |
<Instruct>: Given the context 'This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [crbpii]
<Options>: A: crabp-ii (homo sapiens) (retinol binding protein 2 (homo sapiens)) (aka retinol binding protein 2)
B: crabp-ii (homo sapiens) (cellular retinoic acid binding protein 2 (homo sapiens)) (aka cellular retinoic acid binding protein 2)
C: crbp-iii (homo sapiens) (aka retinol binding protei... | [A] |
<Instruct>: Given the context 'The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [rxr]
<Options>: A: nr1b2 (homo sapiens) (aka retinoic acid receptor beta)
B: rxr-alpha (homo sapiens) (aka retinoid x receptor alpha)
C: nr1h2 (homo sapiens) (aka nuclear receptor subfamily 1 group h member 2)
D: rxr-beta (homo sapiens) (aka retinoid x receptor beta)
E: rxrc (homo sapiens) (aka retinoid x ... | [B] |
<Instruct>: Given the context 'We have isolated a mouse cDNA of 5.7 kb, encoding a new member of the family of receptor-like protein tyrosine phosphatases, termed mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [mrptp mu]
<Options>: A: p-ptp-mu (xenopus tropicalis) (aka protein tyrosine phosphatase, receptor type m)
B: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
C: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
D: rptpmu (mus musculus) (aka protein tyrosine phosphatase... | [D] |
<Instruct>: Given the context 'In addition, we have cloned the human homologue, hRPTP mu, which shows 98.7% amino acid identity to mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrptp mu; mrptp mu]
<Options>: A: hprt (mus musculus) (aka hypoxanthine phosphoribosyltransferase 1)
B: hr-ptpu (homo sapiens) (aka protein tyrosine phosphatase receptor type m)
C: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
D: mtppt1 (mus musculus) (aka solute carrier family 4... | [B; C] |
<Instruct>: Given the context 'In addition, we have cloned the human homologue, hRPTP mu, which shows 98.7% amino acid identity to mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrptp mu; mrptp mu]
<Options>: A: hprt (mus musculus) (aka hypoxanthine phosphoribosyltransferase 1)
B: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
C: trnp (mus musculus) (trna proline, mitochondrial (mus musculus)) (aka trna proline, mitochondrial)
D: r-ptp-u (mus musculus) (aka protein... | [H; E] |
<Instruct>: Given the context 'In addition, we have cloned the human homologue, hRPTP mu, which shows 98.7% amino acid identity to mRPTP mu.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrptp mu; mrptp mu]
<Options>: A: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
B: trnp (mus musculus) (trna proline, mitochondrial (mus musculus)) (aka trna proline, mitochondrial)
C: mtppt1 (mus musculus) (aka solute carrier family 44, member 4)
D: hprt (mus musculus) (aka hyp... | [H; E] |
<Instruct>: Given the context 'The predicted mRPTP mu protein consists of a 722 amino acid extracellular region, containing 13 potential N-glycosylation sites, a single transmembrane domain and a 688 amino acid intracellular part containing 2 tandem repeats homologous to the catalytic domains of other tyrosine phosphat... | <Mentions>: [mrptp mu]
<Options>: A: rptpmu (mus musculus) (aka protein tyrosine phosphatase receptor type m)
B: trna proline, mitochondrial (mus musculus) (aka trna proline, mitochondrial)
C: lmptp (mus musculus) (aka acid phosphatase 1, soluble)
D: r-ptp-mu (homo sapiens) (aka protein tyrosine phosphatase receptor ty... | [A] |
<Instruct>: Given the context 'Transfection of the mRPTP mu cDNA into COS cells results in the synthesis of a protein with an apparent Mr of 195,000, as detected in immunoblots using an antipeptide antibody.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [mrptp mu]
<Options>: A: mtrpol (mus musculus) (aka polymerase (rna) mitochondrial (dna directed))
B: p-ptp-mu (xenopus tropicalis) (aka protein tyrosine phosphatase, receptor type m)
C: trna proline, mitochondrial (mus musculus) (aka trna proline, mitochondrial)
D: mrptprho (mus musculus) (aka protein tyro... | [E] |
<Instruct>: Given the context 'The human RPTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in human cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [rptp mu]
<Options>: A: rptpalpha (mus musculus) (aka protein tyrosine phosphatase receptor type a)
B: p-ptp-mu (xenopus tropicalis) (aka protein tyrosine phosphatase, receptor type m)
C: protein tyrosine phosphatase receptor type u (homo sapiens) (aka protein tyrosine phosphatase receptor type u)
D: r-ptp-... | [D] |
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