instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'Cytotoxic lymphocyte maturation factor (CLMF) is a disulfide-bonded heterodimeric lymphokine that (i) acts as a growth factor for activated T cells independent of interleukin 2 and (ii) synergizes with suboptimal concentrations of interleukin 2 to induce lymphokine-activated killer cells.... | <Mentions>: [interleukin 2]
<Options>: A: il-2 (homo sapiens) (aka interleukin 2)
B: interleukin 3 (homo sapiens) (aka interleukin 3)
C: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
D: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
E: interleukin 7 (homo sapiens) (aka in... | [A] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: g protein-coupled receptor 45 (rattus norvegicus) (aka g protein-coupled receptor 45)
B: blast-2 (homo sapiens) (aka fc epsilon receptor ii)
C: vacuolar protein sorting 45 homolog (oryctolagus cuniculus) (aka vacuolar protein sorting 45 homolog)
D: bcmo1 (homo sapiens) (a... | [F; F; F] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
B: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
C: gpr45 (rattus norvegicus) (aka g protein-coupled receptor 45)
D: bcrm1 (homo sapiens) (aka sideroflexin 4)
E: gpr45 (oryctolagus cuniculus) (aka g protein-coupl... | [M; M; M] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: vacuolar protein sorting 45 homolog (oryctolagus cuniculus) (aka vacuolar protein sorting 45 homolog)
B: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: blast1 (homo sapiens) (aka cd48 molecule)
E: gpr... | [N; N; N] |
<Instruct>: Given the context 'Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
B: bsf-1 (homo sapiens) (aka interleukin 4)
C: bcm1 (homo sapiens) (aka cd48 molecule)
D: blast-2 (homo sapiens) (aka fc epsilon receptor ii)
E: cdcbm1 (homo sapiens) (aka tubulin be... | [M; M; M] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: bcm1 (homo sapiens) (aka cd48 molecule)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
D: lfa3 (homo sapiens) (aka cd58 molecule)
E: bcrm1 (homo sapiens) (aka sideroflexin 4)
F: lfa1a (homo sapiens) (aka ... | [A; K; D] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: leu-3 (homo sapiens) (aka cd4 molecule)
B: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
C: cd22 molecule (homo sapiens) (aka cd22 molecule)
D: lfa1a (homo sapiens) (aka integrin subunit alpha l)
E: bcm (homo sapiens) (aka tnf rec... | [K; G; H] |
<Instruct>: Given the context 'Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: lfa1a (homo sapiens) (aka integrin subunit alpha l)
C: cd228 (homo sapiens) (aka melanotransferrin)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
F: bcm1 (homo sapiens) (aka ... | [F; K; I] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: g protein-coupled receptor 45 (oryctolagus cuniculus) (aka g protein-coupled receptor 45)
B: blast (homo sapiens) (aka cd48 molecule)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: blast-2 (homo sapiens) (aka fc epsilon receptor ii)
E: bcms1 (homo sapie... | [M; M; B] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: g protein-coupled receptor 45 (oryctolagus cuniculus) (aka g protein-coupled receptor 45)
B: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
C: olr45 (rattus norvegicus) (aka olfactory receptor family 52 subfamily k member 2)
D: bcm-1 (mus musculus) (aka cd48 antigen... | [D; D; E] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1; ox45; blast-1]
<Options>: A: gpr45 (oryctolagus cuniculus) (aka g protein-coupled receptor 45)
B: bcrm1 (homo sapiens) (aka sideroflexin 4)
C: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
D: bsf-1 (homo sapiens) (aka interleukin 4)
E: mbc1 (homo sapiens) (aka coiled-coil domain contai... | [I; I; H] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [lfa3; cd2]
<Options>: A: cd21 (homo sapiens) (aka complement c3d receptor 2)
B: cd2 molecule (homo sapiens) (aka cd2 molecule)
C: lfa-2 (homo sapiens) (aka cd2 molecule)
D: cd228 (homo sapiens) (aka melanotransferrin)
E: cd2 molecule (bos taurus) (aka cd2 molecule)
F: lfa-1 (homo sapiens) (integrin subunit... | [I; B] |
<Instruct>: Given the context 'The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [lfa3; cd2]
<Options>: A: cd11a (homo sapiens) (aka integrin subunit alpha l)
B: cd228 (homo sapiens) (aka melanotransferrin)
C: cd21 (homo sapiens) (aka complement c3d receptor 2)
D: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
E: lfa-2 (homo sapiens) (aka cd2... | [J; H] |
<Instruct>: Given the context 'Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol anchor, as is the case for rat and human BCM1 antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [bcm1]
<Options>: A: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
B: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
C: bcm1 (mus musculus) (aka cd48 antigen)
D: bcm1 (homo sapiens) (aka cd48 molecule)
E: cnnm1 (bos taurus) (aka cyclin and cbs domain divalent metal cation transport media... | [D] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: bcm1 (homo sapiens) (aka cd48 molecule)
B: bcsc-1 (homo sapiens) (aka von willebrand factor a domain containing 5a)
C: mb-1 (homo sapiens) (aka cd79a molecule)
D: atpap3 (arabidopsis thaliana) (aka purple acid phosphatase 3)
E: bcrm1 (homo sapiens) (aka sideroflexin 4)
F:... | [H; H; L] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: bcm1 (homo sapiens) (aka cd48 molecule)
B: atp13a3 (xenopus tropicalis) (aka atpase type 13a3)
C: mb-1 (homo sapiens) (aka cd79a molecule)
D: atpap3 (arabidopsis thaliana) (aka purple acid phosphatase 3)
E: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
F: cn... | [H; H; K] |
<Instruct>: Given the context 'Genetic linkage studies by recombination and pulse field analysis showed the BCM1 locus (Bcm-1) to be on distal mouse chromosome 1 and to be linked within 1,600 kb to the locus for an ATPase alpha chain gene (Atpa-3).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [bcm1; bcm-1; atpa-3]
<Options>: A: bcm (homo sapiens) (aka tnf receptor superfamily member 17)
B: mb-1 (homo sapiens) (aka cd79a molecule)
C: bcm-1 (mus musculus) (aka cd48 antigen)
D: atppa3 (arabidopsis thaliana) (aka pyrophosphorylase 3)
E: bcmp1 (homo sapiens) (aka transmembrane protein 47)
F: bcm1 (ho... | [C; C; I] |
<Instruct>: Given the context 'A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcm1; atp1a2]
<Options>: A: atpase na+/k+ transporting subunit alpha 2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
B: atp1a2 (mus musculus) (aka atpase, na+/k+ transporting, alpha 2 polypeptide)
C: atp2c1a (homo sapiens) (aka atpase secretory pathway ca2+ transporting 1)
D: bcms1 (homo ... | [H; A] |
<Instruct>: Given the context 'A similar relationship was established between the human BCM1 locus (BCM1) and ATP1A2, and other markers on chromosome 1q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcm1; atp1a2]
<Options>: A: bcm1 (mus musculus) (aka cd48 antigen)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: atp2a2 (homo sapiens) (aka atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2)
D: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
E: atp1a2 (rattus norvegicus) (aka atpase na+/k+... | [B; J] |
<Instruct>: Given the context 'A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd2; lfa3]
<Options>: A: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd22 molecule (homo sapiens) (aka cd22 molecule)
D: lfa-2 (homo sapiens) (aka cd2 molecule)
E: leu-3 (homo sapiens) (aka cd4 molecule)
F: itga3 (homo sapiens) (aka integrin su... | [H; I] |
<Instruct>: Given the context 'A similar situation is seen in the region of the CD2 and LFA3 genes between mouse chromosome 3 and human chromosome 1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd2; lfa3]
<Options>: A: lfa3 (homo sapiens) (aka cd58 molecule)
B: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
C: integrin subunit alpha 3 (homo sapiens) (aka integrin subunit alpha 3)
D: cd2 (homo sapiens) (aka cd2 molecule)
E: lfa1a (homo sapiens) (aka integrin subunit alpha l... | [D; A] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: cd228 (homo sapiens) (aka melanotransferrin)
B: atp synthase f1 subunit alpha pseudogene 1 (homo sapiens) (aka atp synthase f1 subunit alpha pseudogene 1)
C: atp1a2 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 2)
D: atp synthase f1 subunit alpha (hom... | [K; G; U; M] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: atpase na+/k+ transporting subunit alpha 1 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 1)
B: lfa1a (homo sapiens) (aka integrin subunit alpha l)
C: atp6n1a (homo sapiens) (aka atpase h+ transporting v0 subunit a1)
D: atp1a3 (homo sapiens) (aka atpas... | [M; O; T; A] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: lfa3 (homo sapiens) (aka cd58 molecule)
B: cd2 molecule (homo sapiens) (aka cd2 molecule)
C: atpi (homo sapiens) (aka atp synthase inhibitory factor subunit 1)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: atp1a1 (rattus norvegicus) (aka atpase na+/k+ transporting s... | [B; A; T; O] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [cd2; lfa3; atpa-1; atp1a1]
<Options>: A: lfa-3 (homo sapiens) (aka cd58 molecule)
B: atpi (homo sapiens) (aka atp synthase inhibitory factor subunit 1)
C: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
D: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (ak... | [H; A; U; I] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
B: mbt-1 (homo sapiens) (aka l3mbtl histone methyl-lysine binding protein 3)
C: atp6a2 (homo sapiens) (aka atpase h+ transporting v0 subunit a2)
D: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
E:... | [G; O; N; K] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: atp6a2 (homo sapiens) (aka atpase h+ transporting v0 subunit a2)
B: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
C: atpaf1 (homo sapiens) (aka atp synthase mitochondrial f1 complex assembly factor 1)
D: bcm1 (homo sapiens) (aka cd48 molecule)
E: at... | [K; D; J; I] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
B: bcmp1 (homo sapiens) (aka transmembrane protein 47)
C: atp synthase f1 subunit alpha pseudogene 3 (homo sapiens) (aka atp synthase f1 subunit alpha pseudogene 3)
D: bcm-1 (mus musculus) (aka cd48 antig... | [D; O; N; H] |
<Instruct>: Given the context 'Furthermore, the CD2/LFA3 genes are linked within 580 kb to Atpa-1/ATP1A1 genes to provide a parallel situation to the linkage between Bcm-1/BCM1 and Atpa-3/ATP1A2 on chromosomes 1 (mouse) and 1q (human).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [bcm-1; bcm1; atpa-3; atp1a2]
<Options>: A: bcrm1 (homo sapiens) (aka sideroflexin 4)
B: atp2c1a (homo sapiens) (aka atpase secretory pathway ca2+ transporting 1)
C: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
D: atp1a2 (mus musculus) (aka atpase, na+/k+ transporting, alpha 2 polypeptide)
E: atp2a2... | [G; O; J; K] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: lfa-1 (homo sapiens) (integrin subunit beta 2 (homo sapiens)) (aka integrin subunit beta 2)
B: bcm1 (homo sapiens) (aka cd48 molecule)
C: lfa-3 (homo sapiens) (aka cd58 molecule)
D: lfa-2 (homo sapiens) (aka cd2 molecule)
E: mbc1 (homo sapiens) (aka coiled-coil domain contain... | [B; H; C] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: cd22 (homo sapiens) (aka cd22 molecule)
B: lfa1a (homo sapiens) (aka integrin subunit alpha l)
C: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
D: bcrm1 (homo sapiens) (aka sideroflexin 4)
E: leu-3 (homo sapiens) (aka cd4 molecule)
F: cdcbm1 (homo sapiens) (aka... | [J; O; M] |
<Instruct>: Given the context 'Taken together, the data suggest duplication of a chromosome region including the precursors of the genes for BCM1, CD2, and LFA3, and the ATPase genes to give rise to the linkage groups now observed.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [bcm1; cd2; lfa3]
<Options>: A: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
B: cd2 (gallus gallus) (aka cd2 molecule)
C: cd2 molecule (bos taurus) (aka cd2 molecule)
D: lfa3 (homo sapiens) (aka cd58 molecule)
E: itga3 (homo sapiens) (aka integrin subunit alpha 3)
F: cd22 (homo sapiens) (aka... | [N; G; D] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: lfa3 (homo sapiens) (aka cd58 molecule)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: cd2 (gallus gallus) (aka cd2 molecule)
D: cd2 (homo sapiens) (aka cd2 molecule)
E: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
F: bcm1 (homo sapiens) (aka cd48 molecule)... | [D; A; F] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
B: cd11a (homo sapiens) (aka integrin subunit alpha l)
C: itga3 (homo sapiens) (aka integrin subunit alpha 3)
D: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
E: cd2 (gallus gallus) (aka cd2 molecule)
F: bcm1... | [G; I; F] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd2 (gallus gallus) (aka cd2 molecule)
B: cd2 molecule (homo sapiens) (aka cd2 molecule)
C: bcm1 (homo sapiens) (aka cd48 molecule)
D: cd21 (homo sapiens) (aka complement c3d receptor 2)
E: bcrm1 (homo sapiens) (aka sideroflexin 4)
F: leu-3 (homo sapiens) (aka cd4 molecule)
G... | [B; O; C] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1]
<Options>: A: cd2 (bos taurus) (aka cd2 molecule)
B: cd21 (homo sapiens) (aka complement c3d receptor 2)
C: bcm1 (homo sapiens) (aka cd48 molecule)
D: cd22 (homo sapiens) (aka cd22 molecule)
E: lfa-2 (homo sapiens) (aka cd2 molecule)
F: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
... | [M; N; C] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: cd2 (homo sapiens) (aka cd2 molecule)
B: leu-3 (homo sapiens) (aka cd4 molecule)
C: bcrm1 (homo sapiens) (aka sideroflexin 4)
D: cd21 (homo sapiens) (aka complement c3d receptor 2)
E: cd2 (bos taurus) (aka cd2 molecule)
F: cd22 molecule (homo sapiens) (aka cd22 molecul... | [A; H; G; I] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: bcm1 (homo sapiens) (aka cd48 molecule)
B: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
C: cd2 locus control region (homo sapiens) (aka cd2 locus control region)
D: lfa3 (homo sapiens) (aka cd58 molecule)
E: bcsc-1 (homo sapiens) (aka von willebrand factor a domain... | [M; D; A; L] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: bcm-1 (mus musculus) (aka cd48 antigen)
B: bcrm1 (homo sapiens) (aka sideroflexin 4)
C: lfa-3 (homo sapiens) (aka cd58 molecule)
D: leu-3 (homo sapiens) (aka cd4 molecule)
E: cd22 (homo sapiens) (aka cd22 molecule)
F: integrin subunit alpha 3 (homo sapiens) (aka integr... | [J; C; I; A] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [cd2; lfa3; bcm1; bcm-1]
<Options>: A: slamf3 (homo sapiens) (aka lymphocyte antigen 9)
B: lfa-2 (homo sapiens) (aka cd2 molecule)
C: bcmo1 (homo sapiens) (aka beta-carotene oxygenase 1)
D: lfa-3 (homo sapiens) (aka cd58 molecule)
E: cd2 molecule (homo sapiens) (aka cd2 molecule)
F: bcm1 (homo sapiens) (aka... | [E; D; F; H] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [bcm1]
<Options>: A: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
B: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
C: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
D: bcm1 (homo sapiens) (aka cd48 molecule)
E: bcm-1 (mus musculus) (aka cd48 antigen)
F: None of the above. | [D] |
<Instruct>: Given the context 'The duplicated regions may have stayed together on chromosome 1 in the human (with the insertion of a centromere), while in the mouse, the genetic regions are proposed to have become dispersed in the formation of chromosomes 1 and 3. CD2 and LFA3 are more dissimilar in sequence than BCM1 ... | <Mentions>: [bcm1]
<Options>: A: cdcbm1 (homo sapiens) (aka tubulin beta 3 class iii)
B: bcm-1 (mus musculus) (aka cd48 antigen)
C: bcms1 (homo sapiens) (aka deleted in lymphocytic leukemia 1)
D: mbc1 (homo sapiens) (aka coiled-coil domain containing 112)
E: None of the above. | [E] |
<Instruct>: Given the context 'The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [type i tnf-r]
<Options>: A: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
B: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnfr2 (homo sapiens) (aka tnf receptor superfamily member 1b)
D: None of the above. | [B] |
<Instruct>: Given the context 'Two proteins which specifically bind tumor necrosis factor (TNF) have recently been isolated from human urine in our laboratory.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [tumor necrosis factor; tnf]
<Options>: A: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
B: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tumor ne... | [G; G] |
<Instruct>: Given the context 'Two proteins which specifically bind tumor necrosis factor (TNF) have recently been isolated from human urine in our laboratory.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [tumor necrosis factor; tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tumor necrosis factor (xenopus tropicalis) (aka tumor necrosis factor)
D: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
E: tnfa (homo... | [E; E] |
<Instruct>: Given the context 'Antibodies against one of the two TNF binding proteins (TBPI) were found to have effects characteristic of TNF, including stimulating phosphorylation of specific cellular proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [tnf]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
C: tnfa (homo sapiens) (aka tumor necrosis factor)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily membe... | [C] |
<Instruct>: Given the context 'Oligonucleotide probes designed on the basis of the NH2-terminal amino acid sequence of TBPI were used to clone the cDNA for the structurally related cell surface type 1 TNF-R. It is notable that although this receptor can signal the phosphorylation of cellular proteins, it appears from i... | <Mentions>: [cell surface type 1 tnf-r]
<Options>: A: dcr1-tnfr (homo sapiens) (aka tnf receptor superfamily member 10c)
B: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
C: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
E: None of ... | [C] |
<Instruct>: Given the context 'The extracellular domain of the receptor is composed of four internal cysteine-rich repeats, homologous to structures repeated four times in the extracellular domains of the nerve growth factor receptor and the B lymphocytes surface antigen CDw40.', select the correct biomedical concept f... | <Mentions>: [nerve growth factor receptor; cdw40]
<Options>: A: interleukin 4 receptor (homo sapiens) (aka interleukin 4 receptor)
B: il-40 (homo sapiens) (aka chromosome 17 open reading frame 99)
C: p75tnfr (homo sapiens) (aka tnf receptor superfamily member 1b)
D: cd40 molecule (homo sapiens) (aka cd40 molecule)
E: c... | [J; D] |
<Instruct>: Given the context 'The extracellular domain of the receptor is composed of four internal cysteine-rich repeats, homologous to structures repeated four times in the extracellular domains of the nerve growth factor receptor and the B lymphocytes surface antigen CDw40.', select the correct biomedical concept f... | <Mentions>: [nerve growth factor receptor; cdw40]
<Options>: A: cd40 molecule (homo sapiens) (aka cd40 molecule)
B: nerve growth factor receptor (bos taurus) (aka nerve growth factor receptor)
C: p75tnfr (homo sapiens) (aka tnf receptor superfamily member 1b)
D: tp40 (homo sapiens) (aka cd7 molecule)
E: hcd40l (homo sa... | [J; A] |
<Instruct>: Given the context 'The amino acid composition and size of the extracellular domain of the type I TNF-R closely resemble those of TBPI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type i tnf-r]
<Options>: A: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
C: tnf receptor superfamily member 1a (homo sapiens) (aka tnf receptor superfamily member 1a)
D: None of the above. | [C] |
<Instruct>: Given the context 'The COOH-terminal amino acid sequence of the four cysteine rich repeats within the extracellular domain of the type I TNF-R matches the COOH-terminal sequence of TBPI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [type i tnf-r]
<Options>: A: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
B: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
C: tnfar (homo sapiens) (aka tnf receptor superfamily member 1a)
D: None of the above. | [C] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
C: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
E:... | [G; G; A] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: tnfr3 (homo sapiens) (aka lymphotoxin beta receptor)
B: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tbpl2 (homo sapiens) (aka tata-box binding protein like 2)
E: tbp (xe... | [J; J; B] |
<Instruct>: Given the context 'On the other hand, amino acid sequences in the soluble form of the type II TNF-R (TBPII), while indicating a marked homology of structure, did not suggest any identity between this protein and the extracellular domain of the type I TNF-R. CHO cells transfected with type I TNF-R cDNA produ... | <Mentions>: [type ii tnf-r; tbpii; type i tnf-r]
<Options>: A: trailr2 (homo sapiens) (aka tnf receptor superfamily member 10b)
B: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tnfr-rp (homo sapiens) (aka lymphotoxin beta receptor)
E:... | [G; G; C] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: cd44 molecule (in blood group) (xenopus tropicalis) (aka cd44 molecule (in blood group))
B: cd44 (homo sapiens) (aka cd44 molecule (in blood group))
C: hyaluronan mediated motility receptor (homo sapiens) (aka hyaluronan mediated motility receptor)
D: cd44 ... | [G; B; I] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: tnfc (homo sapiens) (aka lymphotoxin beta)
B: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
C: tnfa (homo sapiens) (aka tumor necrosis factor)
D: tnfb (homo sapiens) (aka lymphotoxin alpha)
E: hyaluronan mediated motility receptor (homo sapiens)... | [O; M; C] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tsg-6; cd44; tumor necrosis factor]
<Options>: A: cd44 (homo sapiens) (aka cd44 molecule (in blood group))
B: cd44 molecule (in blood group) (xenopus tropicalis) (aka cd44 molecule (in blood group))
C: tsg6 (homo sapiens) (aka tnf alpha induced protein 6)
D: tex6 (homo sapiens) (aka rna polymerase i subuni... | [C; A; E] |
<Instruct>: Given the context 'A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-... | <Mentions>: [tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
E: tnf (homo sapiens) (aka tumor n... | [E] |
<Instruct>: Given the context 'We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [tsg-6; tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: tnf (homo sapiens) (aka tumor necrosis factor)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
E: tnf alpha induced protein 6 (homo sapiens) ... | [E; B] |
<Instruct>: Given the context 'We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [tsg-6; tnf]
<Options>: A: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
B: tnfa (homo sapiens) (aka tumor necrosis factor)
C: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
D: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
E: tsg-9 (homo sap... | [J; B] |
<Instruct>: Given the context 'In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tsg-6; tnf]
<Options>: A: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
B: tumor necrosis factor (homo sapiens) (aka tumor necrosis factor)
C: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
D: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
E: tsg-6 (bos taur... | [H; B] |
<Instruct>: Given the context 'In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tsg-6; tnf]
<Options>: A: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
B: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcr... | [F; I] |
<Instruct>: Given the context 'In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tsg-6; tnf]
<Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
C: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
D: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked ... | [J; I] |
<Instruct>: Given the context 'The sequence of full-length TSG-6 cDNA revealed one major open reading frame predicting a polypeptide of 277 amino acids, including a typical cleavable signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [tsg-6]
<Options>: A: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
B: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
C: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
D: tsg6 (homo sapiens) (aka tnf alpha induced protein 6)
E: melan... | [D] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
B: cd44 molecule (in blood group) (oryctolagus cuniculus) (aka cd44 molecule (in blood group))
C: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
D: hyaluronan and proteoglycan link protein ... | [N; D; G] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: cd44 molecule (in blood group) (oryctolagus cuniculus) (aka cd44 molecule (in blood group))
B: hyaluronan and proteoglycan link protein 2 (homo sapiens) (aka hyaluronan and proteoglycan link protein 2)
C: cd44 molecule (in blood group) (xenopus tropicalis)... | [O; N; J] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
B: cap-gly domain-containing linker protein 1 homolog (caenorhabditis elegans) (aka cap-gly domain-containing linker protein 1 homolog)
C: hyaluronan and proteoglycan link protein 1 (mus musculus) (aka h... | [D; G; J] |
<Instruct>: Given the context 'The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44.', select the correct biomedical concept for each menti... | <Mentions>: [tsg-6; cartilage link protein; cd44]
<Options>: A: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
B: cap-gly domain-containing linker protein 1 homolog (caenorhabditis elegans) (aka cap-gly domain-containing linker protein 1 homolog)
C: hyaluronan and proteoglycan link protein 1 (homo sapiens) (... | [O; C; G] |
<Instruct>: Given the context 'The most extensive sequence homology exists between the predicted TSG-6 protein and CD44.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6; cd44]
<Options>: A: tsg-6 (homo sapiens) (aka tnf alpha induced protein 6)
B: cd44 (mus musculus) (aka cd44 antigen)
C: cd44 molecule (in blood group) (homo sapiens) (aka cd44 molecule (in blood group))
D: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-lin... | [A; C] |
<Instruct>: Given the context 'The most extensive sequence homology exists between the predicted TSG-6 protein and CD44.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6; cd44]
<Options>: A: cd44 molecule (sus scrofa) (aka cd44 molecule)
B: lhr (homo sapiens) (cd44 molecule (in blood group) (homo sapiens)) (aka cd44 molecule (in blood group))
C: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
D: tsg-6 (bos taurus) (aka tnf alpha... | [F; B] |
<Instruct>: Given the context 'Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39-kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [tsg-6; tnf]
<Options>: A: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
B: tsg6 (homo sapiens) (aka tnf alpha induced protein 6)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: tnfsf1 (homo sapiens) (aka lymphotoxin alpha)
E: tnfa (homo sapiens) (aka tumor necrosis fa... | [B; E] |
<Instruct>: Given the context 'Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39-kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [tsg-6; tnf]
<Options>: A: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
B: tnfc (homo sapiens) (aka lymphotoxin beta)
C: testis expressed transcript, y-linked 6 (homo sapiens) (aka testis expressed transcript, y-linked 6)
D: tumor necrosis factor (homo sapiens) (aka tumor necrosis ... | [H; D] |
<Instruct>: Given the context 'Binding of the TSG-6 protein to hyaluronate was demonstrated by coprecipitation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsg-6]
<Options>: A: tsg-6 (homo sapiens) (aka tnf alpha induced protein 6)
B: tsg7 (homo sapiens) (aka suppression of tumorigenicity 7)
C: tsg-6 (bos taurus) (aka tnf alpha induced protein 6)
D: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
E: melanoma-associated transcript 6 (homo sapiens) (aka... | [A] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: tsg-6 (mus musculus) (aka tumor necrosis factor alpha induced protein 6)
B: melanoma-associated transcript 6 (homo sapiens) (aka melanoma-associated transcript 6)
C: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
D: interleukin 1 alpha (homo sapiens) ... | [J; O; G] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: il-1h1 (homo sapiens) (aka interleukin 36 gamma)
B: tnf alpha induced protein 6 (homo sapiens) (aka tnf alpha induced protein 6)
C: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
D: tsg-9 (homo sapiens) (aka tumor suppressor candidate 1)
E: tnfa (ho... | [E; I; B] |
<Instruct>: Given the context 'Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.', select the correct biomed... | <Mentions>: [tnf; il-1; tsg-6]
<Options>: A: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
B: il-1 (homo sapiens) (aka interleukin 1 beta)
C: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
D: tnf superfamily member 4 (homo sapiens) (aka tnf superfamily member 4)
E: tex6 (homo sapiens)... | [N; B; H] |
<Instruct>: Given the context 'Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc2]
<Options>: A: cdc28 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase cdc28)
B: cdc2 (homo sapiens) (cyclin dependent kinase 1 (homo sapiens)) (aka cyclin dependent kinase 1)
C: anaphase promoting complex subunit cdc27 (saccharomyces cerevisiae s288c) (aka anaphas... | [B] |
<Instruct>: Given the context 'We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle.', select the correct biomedical concept for each... | <Mentions>: [ched; cholinesterase-related cell division controller]
<Options>: A: crnde (homo sapiens) (aka colorectal neoplasia differentially expressed)
B: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog)
C: hdc homolog, cell cycle regulator (xenopus tropicalis) (aka hdc homolog, cell cycle regulator... | [J; J] |
<Instruct>: Given the context 'We now present cloning of a cDNA coding for CHED (cholinesterase-related cell division controller), a human homolog of the Schizosaccharomyces pombe cell division cycle 2 (cdc2)-like kinases, universal controllers of the mitotic cell cycle.', select the correct biomedical concept for each... | <Mentions>: [ched; cholinesterase-related cell division controller]
<Options>: A: hdc homolog, cell cycle regulator (xenopus tropicalis) (aka hdc homolog, cell cycle regulator)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: chrd (gallus gallus) (aka chordin)
D: ch... | [B; B] |
<Instruct>: Given the context 'Library screening, RNA blot hybridization, and direct PCR amplification of cDNA reverse-transcribed from cellular mRNA revealed that CHED mRNA is expressed in multiple tissues, including bone marrow.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [ched]
<Options>: A: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
B: ched (escherichia coli str. k-12 substr. mg1655) (aka methyl-accepting chemotaxis protein tsr)
C: ched-related (drosophila melanogaster) (aka uncharacterized protein)
D: ched1 (homo sapie... | [A] |
<Instruct>: Given the context 'The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases, displays 34-42% identically aligned amino acid residues with other cdc2-related kinases, and is considerably longer at its amino and carboxyl termini.', select the correct biomedical... | <Mentions>: [ched]
<Options>: A: ched (escherichia coli str. k-12 substr. mg1655) (aka methyl-accepting chemotaxis protein tsr)
B: ched1 (homo sapiens) (aka ovo like zinc finger 2)
C: choline dehydrogenase (homo sapiens) (aka choline dehydrogenase)
D: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka... | [D] |
<Instruct>: Given the context 'An antisense oligodeoxynucleotide designed to interrupt CHED's expression (AS-CHED) significantly reduced the ratio between CHED mRNA and actin mRNA within 1 hr of its addition to cultures, a reduction that persisted for 4 days.', select the correct biomedical concept for each mention usi... | <Mentions>: [ched]
<Options>: A: ched-related (drosophila melanogaster) (aka uncharacterized protein)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: ched (xenopus laevis) (aka cyclin-dependent kinase 13 l homeolog)
D: chedda (homo sapiens) (aka atrophin 1)
E: ched... | [B] |
<Instruct>: Given the context 'AS-CHED treatment selectively inhibited megakaryocyte development in murine bone marrow cultures but did not prevent other hematopoietic pathways, as evidenced by increasing numbers of mononuclear cells.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [ched]
<Options>: A: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
B: ched (escherichia coli str. k-12 substr. mg1655) (aka methyl-accepting chemotaxis protein tsr)
C: ched-related (drosophila melanogaster) (aka uncharacterized protein)
D: chedda (homo sapi... | [A] |
<Instruct>: Given the context 'An oligodeoxynucleotide blocking production of the acetylcholine-hydrolyzing enzyme, butyrylcholinesterase, displayed a similar inhibition of megakaryocytopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [butyrylcholinesterase]
<Options>: A: e1 (homo sapiens) (butyrylcholinesterase (homo sapiens)) (aka butyrylcholinesterase)
B: butyrylcholinesterase (xenopus tropicalis) (aka butyrylcholinesterase)
C: butyrylcholinesterase (bos taurus) (aka butyrylcholinesterase)
D: butyrylcholinesterase (oryctolagus cunicul... | [A] |
<Instruct>: Given the context 'In contrast, an oligodeoxynucleotide blocking production of the human 2Hs cdc2 homolog interfered with production of the human 2Hs cdc2 homolog interfered with cellular proliferation without altering the cell-type composition of these cultures.', select the correct biomedical concept for ... | <Mentions>: [cdc2]
<Options>: A: anaphase promoting complex subunit cdc23 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc23)
B: cdc2 (homo sapiens) (dna polymerase delta 1, catalytic subunit (homo sapiens)) (aka dna polymerase delta 1, catalytic subunit)
C: p34cdc2 (homo sapiens) (aka cycli... | [C] |
<Instruct>: Given the context 'Therefore, these findings strengthen the link between cholinergic signaling and cell division control in hematopoiesis and implicate both CHED and cholinesterases in this differentiation process.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ched]
<Options>: A: cesd (homo sapiens) (aka lipase a, lysosomal acid type)
B: ched (homo sapiens) (cyclin dependent kinase 13 (homo sapiens)) (aka cyclin dependent kinase 13)
C: chegdd (homo sapiens) (aka oxidation resistance 1)
D: choline dehydrogenase (homo sapiens) (aka choline dehydrogenase)
E: ched (... | [B] |
<Instruct>: Given the context 'Therefore, these findings strengthen the link between cholinergic signaling and cell division control in hematopoiesis and implicate both CHED and cholinesterases in this differentiation process.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ched]
<Options>: A: chegdd (homo sapiens) (aka oxidation resistance 1)
B: cesd (homo sapiens) (aka lipase a, lysosomal acid type)
C: choline dehydrogenase (homo sapiens) (aka choline dehydrogenase)
D: ched (escherichia coli str. k-12 substr. mg1655) (aka methyl-accepting chemotaxis protein tsr)
E: None of ... | [E] |
<Instruct>: Given the context 'The transmembrane desmosomal glycoproteins have been proposed to play a role in cell adhesion; desmoglein I (DGI) is a major member of this class of desmosomal molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [desmoglein i; dgi]
<Options>: A: dgi (mus musculus) (aka desmoglein 1 alpha)
B: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
C: desmoglein 1 alpha (mus musculus) (aka desmoglein 1 alpha)
D: dgki (homo sapiens) (aka diacylglycerol kinase iota)
E: dsg1 (homo sapiens) (aka desmoglein 1)
F: desmoglein ... | [E; E] |
<Instruct>: Given the context 'The transmembrane desmosomal glycoproteins have been proposed to play a role in cell adhesion; desmoglein I (DGI) is a major member of this class of desmosomal molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [desmoglein i; dgi]
<Options>: A: desmoglein 4 (homo sapiens) (aka desmoglein 4)
B: desmoglein 1 (homo sapiens) (aka desmoglein 1)
C: desmoglein 1 alpha (mus musculus) (aka desmoglein 1 alpha)
D: desmoglein 2 (homo sapiens) (aka desmoglein 2)
E: dgmii (drosophila melanogaster) (aka alpha-mannosidase class i... | [B; B] |
<Instruct>: Given the context 'However, evidence supporting a role for DGI in cell adhesion or in the plaque is lacking.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dgi]
<Options>: A: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
B: dgsi (mus musculus) (aka ess-2 splicing factor)
C: dgsi (homo sapiens) (aka ess-2 spliceosome associated protein)
D: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
E: dg1 (homo sapiens) (aka desmoglein 1)
F: None... | [E] |
<Instruct>: Given the context 'In order to begin to understand DGI function we have identified human cDNA clones encoding the entire mature polypeptide of 1000 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [dgi]
<Options>: A: dgsi (homo sapiens) (aka ess-2 spliceosome associated protein)
B: dgki (homo sapiens) (aka diacylglycerol kinase iota)
C: dg1 (homo sapiens) (aka desmoglein 1)
D: dgi (mus musculus) (aka desmoglein 1 alpha)
E: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
F: None of the... | [C] |
<Instruct>: Given the context 'Our data suggest that like the bovine DGI molecule human DGI is highly related to the calcium-dependent class of cell adhesion molecules known as cadherins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [dgi]
<Options>: A: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
B: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
C: dgi (mus musculus) (aka desmoglein 1 alpha)
D: dgsi (mus musculus) (aka ess-2 splicing factor)
E: dg1 (homo sapiens) (aka desmoglein 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'The highest degree of similarity between human N-cadherin and human DGI, and likewise between bovine DGI and human DGI, is greatest in the most amino-terminal extracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [n-cadherin; dgi]
<Options>: A: neural-cadherin-like (gallus gallus) (aka neural-cadherin-like)
B: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
C: cdh9 (homo sapiens) (aka cadherin 9)
D: cadherin 1 (homo sapiens) (aka cadherin 1)
E: n-cad (drosophila melanogaster) (cadherin-n (drosophi... | [I; H] |
<Instruct>: Given the context 'The highest degree of similarity between human N-cadherin and human DGI, and likewise between bovine DGI and human DGI, is greatest in the most amino-terminal extracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [n-cadherin; dgi]
<Options>: A: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
B: cdhn (homo sapiens) (aka cadherin 2)
C: dgsi (mus musculus) (aka ess-2 splicing factor)
D: dgs-i (homo sapiens) (aka ess-2 spliceosome associated protein)
E: cadherin 1 (homo sapiens) (aka cadherin 1)
F: ca... | [B; J] |
<Instruct>: Given the context 'The cytoplasmic portion of the molecule contains a cadherin-like region and, like bovine DGI, a carboxy-terminal tail that is not present in the cadherins, comprising three additional domains.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [dgi]
<Options>: A: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
B: dgki (homo sapiens) (aka diacylglycerol kinase iota)
C: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
D: dgic (homo sapiens) (aka placenta associated 8)
E: dgs-i (homo sapiens) (aka ess-2 spliceosome ... | [F] |
<Instruct>: Given the context 'One of these contains a novel repeating motif of 29 +/- 1 residues, first identified in bovine DGI.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dgi]
<Options>: A: dgi (mus musculus) (aka desmoglein 1 alpha)
B: dgdi (drosophila melanogaster) (aka gdp dissociation inhibitor)
C: dgi1 (homo sapiens) (aka dentin sialophosphoprotein)
D: dgsi (mus musculus) (aka ess-2 splicing factor)
E: dgki (homo sapiens) (aka diacylglycerol kinase iota)
F: None of the... | [F] |
<Instruct>: Given the context 'Five amino acids that are identical in bovine and human DGI lie in the second of the two predicted beta-strands, and intriguingly contain putative target sites for protein kinase C.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [dgi]
<Options>: A: dgs-i (homo sapiens) (aka ess-2 spliceosome associated protein)
B: dgi (mus musculus) (aka desmoglein 1 alpha)
C: dgic (homo sapiens) (aka placenta associated 8)
D: dg1 (homo sapiens) (aka desmoglein 1)
E: dgmii (drosophila melanogaster) (aka alpha-mannosidase class ii a)
F: None of the ... | [D] |
<Instruct>: Given the context 'Characterization of human loricrin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [loricrin]
<Options>: A: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope precursor protein)
B: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
C: loricrin-like (xenopus tropicalis) (aka loricrin-like)
D: loricrin (bos taurus) (aka loricrin cornified envelope pre... | [B] |
<Instruct>: Given the context 'We have isolated and characterized a full-length cDNA clone encoding human loricrin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [loricrin]
<Options>: A: loricrin (bos taurus) (aka loricrin cornified envelope precursor protein)
B: loricrin-like (xenopus tropicalis) (aka loricrin-like)
C: loricrin (homo sapiens) (aka loricrin cornified envelope precursor protein)
D: loricrin (sus scrofa) (aka loricrin cornified envelope precursor prot... | [C] |
<Instruct>: Given the context 'Curiously, this protein displays major differences from the recently described mouse loricrin (Mehrel, T., Hohl, D., Nakazawa, H., Rothnagel, J.A., Longley, M.A., Bundman, D., Cheng, C.K., Lichti, U., Bisher, M.E., Steven, A. C., Steinert, P.M., Yuspa, S.H., and Roop, D.R. (1990)', select... | <Mentions>: [loricrin]
<Options>: A: loricrin-like (xenopus tropicalis) (aka loricrin-like)
B: loricrin-like (homo sapiens) (aka loricrin-like)
C: loricrin (bos taurus) (aka loricrin cornified envelope precursor protein)
D: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
E: loricrin (rattus ... | [D] |
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