instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Furthermore, we have isolated four peptides from purified human cell envelopes that contain recognizable loricrin sequences and which are cross-linked by the N epsilon-(gamma-glutamyl)lysine isodipeptide bond.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [loricrin]
<Options>: A: loricrin cornified envelope precursor protein (homo sapiens) (aka loricrin cornified envelope precursor protein)
B: loricrin-like (xenopus tropicalis) (aka loricrin-like)
C: loricrin (sus scrofa) (aka loricrin cornified envelope precursor protein)
D: loricrin (rattus norvegicus) (ak... | [A] |
<Instruct>: Given the context 'The presence of such bonds thus affords an explanation for the extraordinary insolubility of loricrin by cross-linking to the cell envelope and can also explain the low steady-state levels of monomeric loricrin in cytoskeletal extracts of epidermis.', select the correct biomedical concept... | <Mentions>: [loricrin]
<Options>: A: loricrin (bos taurus) (aka loricrin cornified envelope precursor protein)
B: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope precursor protein)
C: loricrin cornified envelope precursor protein (homo sapiens) (aka loricrin cornified envelope precursor protein)
D: lo... | [C] |
<Instruct>: Given the context 'We propose a model for the structure of loricrin in which (i) the unusual glycine-serine-rich sequences adopt a flexible loop conformation, indexed on the recurrent aliphatic residues; (ii) inter- or intramolecular isodipeptide and disulfide cross-links induce or stabilize folding of lori... | <Mentions>: [loricrin]
<Options>: A: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope precursor protein)
B: loricrin (sus scrofa) (aka loricrin cornified envelope precursor protein)
C: loricrin-like (homo sapiens) (aka loricrin-like)
D: loricrin cornified envelope precursor protein (homo sapiens) (aka ... | [D] |
<Instruct>: Given the context 'We propose a model for the structure of loricrin in which (i) the unusual glycine-serine-rich sequences adopt a flexible loop conformation, indexed on the recurrent aliphatic residues; (ii) inter- or intramolecular isodipeptide and disulfide cross-links induce or stabilize folding of lori... | <Mentions>: [loricrin]
<Options>: A: loricrin-like (homo sapiens) (aka loricrin-like)
B: loricrin (mus musculus) (aka loricrin cornified envelope precursor protein)
C: loricrin (sus scrofa) (aka loricrin cornified envelope precursor protein)
D: loricrin (oryctolagus cuniculus) (aka loricrin cornified envelope precursor... | [E] |
<Instruct>: Given the context 'Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cocaine- and antidepressant-sensitive human noradrenaline transporter]
<Options>: A: solute carrier family 1 member 2 (homo sapiens) (aka solute carrier family 1 member 2)
B: net (homo sapiens) (solute carrier family 6 member 2 (homo sapiens)) (aka solute carrier family 6 member 2)
C: nact (homo sapiens) (... | [B] |
<Instruct>: Given the context 'We have isolated a complementary DNA clone encoding a human noradrenaline transporter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [noradrenaline transporter]
<Options>: A: slc6a9 (rattus norvegicus) (aka solute carrier family 6 member 9)
B: slc6a1 (rattus norvegicus) (aka solute carrier family 6 member 1)
C: slc6a2 (homo sapiens) (aka solute carrier family 6 member 2)
D: solute carrier family 5 member 2 (rattus norvegicus) (aka solute... | [C] |
<Instruct>: Given the context 'A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [ypt1; sec4]
<Options>: A: sec4 (candida albicans sc5314) (aka rab family gtpase)
B: tpt1 (xenopus laevis) (translationally-controlled tumor protein homolog (xenopus laevis)) (aka translationally-controlled tumor protein homolog)
C: ypt1 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt1)
D: sec4 ... | [C; D] |
<Instruct>: Given the context 'A set of 11 clones encoding putative GTP binding proteins highly homologous to the yeast YPT1/SEC4 gene products have been isolated from an MDCK cell cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [ypt1; sec4]
<Options>: A: sec4l (homo sapiens) (aka rab40b, member ras oncogene family)
B: sec24 (saccharomyces cerevisiae s288c) (aka copii subunit sec24)
C: ypt6 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt6)
D: ypt11 (saccharomyces cerevisiae s288c) (aka rab family gtpase ypt11)
E: tpt1 (... | [G; H] |
<Instruct>: Given the context 'One, the MDCK homolog of rab2, is associated with a structure having the characteristics of an intermediate compartment between the endoplasmic reticulum and the Golgi apparatus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [rab2]
<Options>: A: rab, member of ras oncogene family like 2b (homo sapiens) (aka rab, member of ras oncogene family like 2b)
B: rab2a (homo sapiens) (aka rab2a, member ras oncogene family)
C: rab2l (homo sapiens) (aka ral guanine nucleotide dissociation stimulator like 2)
D: rab, member ras oncogene fami... | [B] |
<Instruct>: Given the context 'The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [rab5; rab7]
<Options>: A: rab7l (homo sapiens) (aka rab29, member ras oncogene family)
B: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka rab7a, member ras oncogene family l homeolog)
C: rab5a (homo sapiens) (aka rab5a, member ras oncogene family)
D: rab-7 (drosop... | [C; H] |
<Instruct>: Given the context 'The second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [rab5; rab7]
<Options>: A: rab5c (homo sapiens) (aka rab5c, member ras oncogene family)
B: rab-7 (drosophila melanogaster) (aka rab7)
C: rab7a (homo sapiens) (aka rab7a, member ras oncogene family)
D: rab7b (homo sapiens) (aka rab7b, member ras oncogene family)
E: rab5 (drosophila melanogaster) (aka rab5)
F... | [F; C] |
<Instruct>: Given the context 'These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ypt1; sec4]
<Options>: A: sec4l (homo sapiens) (aka rab40b, member ras oncogene family)
B: sec4 (saccharomyces cerevisiae s288c) (aka rab family gtpase sec4)
C: exo4 (homo sapiens) (aka synaptotagmin like 2)
D: tpt1 (xenopus laevis) (translationally-controlled tumor protein homolog (xenopus laevis)) (aka t... | [I; B] |
<Instruct>: Given the context 'These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ypt1; sec4]
<Options>: A: sec4l (homo sapiens) (aka rab40b, member ras oncogene family)
B: sec24d (xenopus tropicalis) (sec24 homolog c, copii coat complex component (xenopus tropicalis)) (aka sec24 homolog c, copii coat complex component)
C: sec24 (saccharomyces cerevisiae s288c) (aka copii subunit sec24)... | [I; J] |
<Instruct>: Given the context 'A human homologue of the yeast HDEL receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdel receptor]
<Options>: A: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
B: edr (homo sapiens) (aka paternally expressed 10)
C: kdelr3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
D: kdelr2l (danio rerio) (aka kdel endoplasmic reticulu... | [F] |
<Instruct>: Given the context 'There is evidence that the ERD2 gene encodes the sorting receptor that recognizes HDEL in yeast; its product is an integral membrane protein of relative molecular mass 26,000 (26K) that is not glycosylated.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [erd2]
<Options>: A: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
B: erda2 (homo sapiens) (aka zinc finger protein 384)
C: erdj2 (homo sapiens) (aka sec63 protein translocation regulator)
D: erd2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor... | [F] |
<Instruct>: Given the context 'In contrast, Vaux et al. suggest that the mammalian KDEL receptor is a 72K glycoprotein that they detected using an anti-idiotypic antibody approach.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [kdel receptor]
<Options>: A: kdelr3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
B: kdelr (xenopus tropicalis) (aka kdel endoplasmic reticulum protein retention receptor 3)
C: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 2)
D: kdel (lys-as... | [E] |
<Instruct>: Given the context 'We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [erd2; kdel receptor]
<Options>: A: dre2 (homo sapiens) (aka cytokine induced apoptosis inhibitor 1)
B: erd2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 1)
C: erd2l3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
D: kdelr3 (homo sapiens) (aka kdel ... | [B; B] |
<Instruct>: Given the context 'We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [erd2; kdel receptor]
<Options>: A: dre2 (homo sapiens) (aka cytokine induced apoptosis inhibitor 1)
B: kdelr3 (homo sapiens) (aka kdel endoplasmic reticulum protein retention receptor 3)
C: kdel (lys-asp-glu-leu) endoplasmic reticulum protein retention receptor 1 (mus musculus) (aka kdel (lys-asp-glu-leu) ... | [I; I] |
<Instruct>: Given the context 'We report here that human cells express a protein similar in sequence, size and properties to the ERD2 product, and propose that this protein is the human KDEL receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [erd2; kdel receptor]
<Options>: A: erda2 (homo sapiens) (aka zinc finger protein 384)
B: kdelr3 (danio rerio) (aka kdel endoplasmic reticulum protein retention receptor 3)
C: kdelr (drosophila melanogaster) (aka kdel receptor)
D: kdelr2 (homo sapiens) (aka kdel endoplasmic reticulum protein retention recep... | [E; E] |
<Instruct>: Given the context 'Primary structure and functional expression of rat and human stem cell factor DNAs.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: sf (homo sapiens) (kit ligand (homo sapiens)) (aka kit ligand)
C: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
D: csf1 (homo sapiens) (aka colony stimulating factor 1)
E: gmcsf (homo sapiens) (aka... | [B] |
<Instruct>: Given the context 'Partial cDNA and genomic clones of rat stem cell factor (SCF) have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor; scf]
<Options>: A: scf (homo sapiens) (aka kit ligand)
B: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)... | [I; I] |
<Instruct>: Given the context 'Partial cDNA and genomic clones of rat stem cell factor (SCF) have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stem cell factor; scf]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: csf1 (homo sapiens) (aka colony stimulating factor 1)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: c-kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
E: colony... | [J; J] |
<Instruct>: Given the context 'Using probes based on the rat sequence, partial and full-length cDNA and genomic clones of human SCF have been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [scf]
<Options>: A: kit ligand (homo sapiens) (aka kit ligand)
B: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
C: csf3 (homo sapiens) (aka colony stimulating factor 3)
D: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
E: None of the above. | [A] |
<Instruct>: Given the context 'SCF is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow cultures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [scf]
<Options>: A: kit ligand (homo sapiens) (aka kit ligand)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D: csf-1 (homo sapiens) (aka colony stimulating factor 1)
E: None of the above. | [A] |
<Instruct>: Given the context 'SCF exhibits potent synergistic activities in conjunction with colony-stimulating factors, resulting in increased colony numbers and colony size.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [scf]
<Options>: A: csf3 (homo sapiens) (aka colony stimulating factor 3)
B: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
C: csf2 (homo sapiens) (aka colony stimulating factor 2)
D: kit ligand (homo sapiens) (aka kit ligand)
E: None of the above. | [D] |
<Instruct>: Given the context 'SCF exhibits potent synergistic activities in conjunction with colony-stimulating factors, resulting in increased colony numbers and colony size.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [scf]
<Options>: A: colony stimulating factor 1 (homo sapiens) (aka colony stimulating factor 1)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: csf3 (homo sapiens) (aka colony stimulating factor 3)
D: None of the above. | [D] |
<Instruct>: Given the context 'Autoantibodies to a novel nuclear Ag, Sp100, have recently been described that recognize a nuclear protein with an apparent molecular mass of 95 to 100 kDa and a dot-like distribution within cell nuclei.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [sp100]
<Options>: A: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
B: sp100 (drosophila melanogaster) (aka jonah 44e)
C: crsp100 (homo sapiens) (aka mediator complex subunit 24)
D: sp100 (bos taurus) (aka sp100 nuclear antigen)
E: sp140 (homo sapiens) (aka sp140 nuclear body protein)
F: ... | [A] |
<Instruct>: Given the context 'By immunoscreening of a lambda gt11 cDNA expression library derived from HeLa cells with an anti-Sp100 autoimmune serum a 0.7-kb cDNA (Sp26) coding for a fragment of Sp100 was isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [sp100]
<Options>: A: crsp100 (homo sapiens) (aka mediator complex subunit 24)
B: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
C: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
D: nuclear antigen sp100 (mus musculus) (aka nuclear antigen sp100)
E: sp100-rs (mus musculus... | [B] |
<Instruct>: Given the context 'Expression of this cDNA and use of the recombinant protein in ELISA revealed that the fragment carries major Sp100 autoepitopes and that anti-Sp100 autoantibodies predominantly occur in patients suffering from primary biliary cirrhosis (50/184).', select the correct biomedical concept for... | <Mentions>: [sp100]
<Options>: A: sp140 (homo sapiens) (aka sp140 nuclear body protein)
B: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
C: sp100 (bos taurus) (aka sp100 nuclear antigen)
D: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
E: sp100 (drosophila melanogaster) (aka jonah ... | [B] |
<Instruct>: Given the context 'The Sp100 autoantigen expressed in vitro from this cDNA and authenticated by a capture immunoblot assay, comigrated in SDS-PAGE with the authentic HeLa autoantigen of 95 to 100 kDa and thus showed an aberrant electrophoretic mobility.', select the correct biomedical concept for each menti... | <Mentions>: [sp100]
<Options>: A: sp100 (homo sapiens) (aka sp100 nuclear antigen)
B: sp100 (mus musculus) (aka nuclear antigen sp100)
C: crsp100 (homo sapiens) (aka mediator complex subunit 24)
D: sp140 (homo sapiens) (aka sp140 nuclear body protein)
E: sp100 (sus scrofa) (aka nuclear body protein sp140-like protein)
... | [A] |
<Instruct>: Given the context 'Computer based protein sequence analysis of the Sp100 autoantigen revealed regions of striking sequence similarities to the alpha 1 and alpha 2 domains of various human and non-human MHC class I Ag and to several transacting transcriptional regulatory proteins.', select the correct biomed... | <Mentions>: [sp100]
<Options>: A: sp100 (drosophila melanogaster) (aka jonah 44e)
B: sp100 (mus musculus) (aka nuclear antigen sp100)
C: sp100 (bos taurus) (aka sp100 nuclear antigen)
D: crsp100 (homo sapiens) (aka mediator complex subunit 24)
E: sp100 nuclear antigen (homo sapiens) (aka sp100 nuclear antigen)
F: None ... | [E] |
<Instruct>: Given the context 'Although cell surface receptors for the Fc region of IgA (Fc alpha R) have been implicated in a variety of immune effector mechanisms, the molecular features of Fc alpha R remain only marginally characterized.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [fc alpha r]
<Options>: A: fcalphar (homo sapiens) (aka fc alpha receptor)
B: fcriiia (homo sapiens) (aka fc gamma receptor iiia)
C: fcamr (homo sapiens) (aka fc alpha and mu receptor)
D: fcgammariia (homo sapiens) (aka fc gamma receptor iia)
E: fcgr1a (homo sapiens) (aka fc gamma receptor ia)
F: None of th... | [A] |
<Instruct>: Given the context 'Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).', select the correct biomedical concept for each mention usi... | <Mentions>: [fc alpha r; fc epsilon ri]
<Options>: A: fcgr (homo sapiens) (aka fc gamma receptor iia)
B: fc epsilon receptor ia (homo sapiens) (aka fc epsilon receptor ia)
C: fc epsilon receptor ig (homo sapiens) (aka fc epsilon receptor ig)
D: fcgriiia (homo sapiens) (aka fc gamma receptor iiia)
E: fcriic (homo sapien... | [I; B] |
<Instruct>: Given the context 'Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).', select the correct biomedical concept for each mention usi... | <Mentions>: [fc alpha r; fc epsilon ri]
<Options>: A: fcamr (homo sapiens) (aka fc alpha and mu receptor)
B: fcgr (homo sapiens) (aka fc gamma receptor iia)
C: fc alpha receptor (homo sapiens) (aka fc alpha receptor)
D: fc-gamma riii (rattus norvegicus) (aka fc gamma receptor 2a)
E: fcriiia (homo sapiens) (aka fc gamma... | [C; I] |
<Instruct>: Given the context 'Databank searches indicate that the human myeloid cell Fc alpha R sequence is unique, is a member of the immunoglobulin gene superfamily, and is related to Fc receptors for IgG (Fc gamma RI, II, and III) and IgE (Fc epsilon RI).', select the correct biomedical concept for each mention usi... | <Mentions>: [fc alpha r; fc epsilon ri]
<Options>: A: fc-gamma riii (rattus norvegicus) (aka fc gamma receptor 2a)
B: fcriiia (homo sapiens) (aka fc gamma receptor iiia)
C: fc alpha receptor (homo sapiens) (aka fc alpha receptor)
D: fcamr (homo sapiens) (aka fc alpha and mu receptor)
E: fcgr (homo sapiens) (aka fc gamm... | [C; J] |
<Instruct>: Given the context 'Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (homo sapiens) (aka ferrochelatase)
B: ferrochelatase (danio rerio) (aka ferrochelatase)
C: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
D: ferrochelatase-like (caenorhabditis elegans) (aka ferrochelatase-like)
E: ferrochelatase (escherichia col... | [A] |
<Instruct>: Given the context 'The cDNA encoding human ferrochelatase', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (danio rerio) (aka ferrochelatase)
B: ferrochelatase (xenopus tropicalis) (aka ferrochelatase)
C: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
D: ferrochelatase (homo sapiens) (aka ferrochelatase)
E: ferrochelatase (escherichia coli str. k-12 su... | [D] |
<Instruct>: Given the context '[EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ec 4.99.1.1; ferrochelatase]
<Options>: A: ferrochelatase (bos taurus) (aka ferrochelatase)
B: dj994e9.6 (homo sapiens) (aka olfactory receptor family 11 subfamily a member 1)
C: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
D: family with sequence similarity 99 member a ... | [K; K] |
<Instruct>: Given the context '[EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [ec 4.99.1.1; ferrochelatase]
<Options>: A: ferrochelatase (danio rerio) (aka ferrochelatase)
B: ferrochelatase (xenopus tropicalis) (aka ferrochelatase)
C: cgi-99 (homo sapiens) (aka rna transcription, translation and transport factor)
D: dj994e9.1 (homo sapiens) (aka ribosomal protein s17 pseudogene 1)
E:... | [K; K] |
<Instruct>: Given the context 'Northern blot analysis showed two mRNAs of about 2500 and 1600 bp for ferrochelatase in K562 and HepG2 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (oryctolagus cuniculus) (aka ferrochelatase)
B: ferrochelatase (drosophila melanogaster) (aka ferrochelatase)
C: ferrochelatase (escherichia coli str. k-12 substr. mg1655) (aka ferrochelatase)
D: ferrochelatase (homo sapiens) (aka ferrochelatase)
E: ferrochelata... | [D] |
<Instruct>: Given the context 'As full-length cDNA for human ferrochelatase is now available, molecular lesions related to erythropoietic protoporphyria can be characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [ferrochelatase]
<Options>: A: ferrochelatase (homo sapiens) (aka ferrochelatase)
B: ferrochelatase (xenopus tropicalis) (aka ferrochelatase)
C: ferrochelatase (gallus gallus) (aka ferrochelatase)
D: ferrochelatase (caenorhabditis elegans) (aka ferrochelatase)
E: ferrochelatase (bos taurus) (aka ferrochelat... | [A] |
<Instruct>: Given the context 'Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase; bile salt-stimulated milk lipase]
<Options>: A: liver carboxylesterase (sus scrofa) (aka liver carboxylesterase)
B: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
C: carboxyl ester lipase pseudogene (homo sapiens) (aka carboxyl ester lipase pseudogene)
D: li... | [E; E] |
<Instruct>: Given the context 'Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase; bile salt-stimulated milk lipase]
<Options>: A: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
B: carboxyl ester lipase pseudogene (homo sapiens) (aka carboxyl ester lipase pseudogene)
C: lipase e, hormone sensitive type (sus scrofa) (aka lipase e, hormone s... | [G; G] |
<Instruct>: Given the context 'Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase; bile salt-stimulated milk lipase]
<Options>: A: monoglyceride lipase (bos taurus) (aka monoglyceride lipase)
B: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
C: pancreatic lipase (bos taurus) (aka pancreatic lipase)
D: carboxyl ester lipase (sus scrofa) (... | [B; B] |
<Instruct>: Given the context 'Three overlapping cDNA clones covering the entire primary sequence of the bile salt stimulated lipase in human milk were isolated from a human breast lambda gt10 cDNA library by screening with the rat pancreatic cholesterol esterase cDNA.', select the correct biomedical concept for each m... | <Mentions>: [pancreatic cholesterol esterase]
<Options>: A: liver carboxylesterase (sus scrofa) (aka liver carboxylesterase)
B: carboxyl ester lipase pseudogene (homo sapiens) (aka carboxyl ester lipase pseudogene)
C: lipase e, hormone sensitive type (sus scrofa) (aka lipase e, hormone sensitive type)
D: carboxyl ester... | [F] |
<Instruct>: Given the context 'Nucleotide sequencing of the cDNA showed that the human milk lipase mRNA encodes a 748-residue protein, including a 23-residue signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [milk lipase]
<Options>: A: lipase (mus musculus) (aka lipase, endothelial)
B: lipase h (bos taurus) (aka lipase h)
C: lipase h (gallus gallus) (aka lipase h)
D: lipase, gastric (mus musculus) (aka lipase, gastric)
E: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
F: None of the above. | [E] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: lipase h (gallus gallus) (aka lipase h)
B: carboxyl ester lipase (oryctolagus cuniculus) (aka carboxyl ester lipase)
C: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
D: lipase e, hormone sensitive type (oryct... | [F; N; F] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: pancreatic triacylglycerol lipase-like (gallus gallus) (aka pancreatic triacylglycerol lipase-like)
B: pancreatic lipase (homo sapiens) (aka pancreatic lipase)
C: carboxylesterase 1 (oryctolagus cuniculus) (aka carboxylestera... | [J; N; J] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: cocaine esterase (oryctolagus cuniculus) (loc127491327 (oryctolagus cuniculus)) (aka cocaine esterase)
B: carboxyl ester lipase (oryctolagus cuniculus) (aka carboxyl ester lipase)
C: monoglyceride lipase (gallus gallus) (aka ... | [M; M; M] |
<Instruct>: Given the context 'The human milk lipase cDNA is highly homologous to rat pancreatic cholesterol esterase, suggesting that the milk lipase may be identical to the cholesterol esterase in human pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [milk lipase; pancreatic cholesterol esterase; cholesterol esterase]
<Options>: A: lipase e, hormone sensitive type (sus scrofa) (aka lipase e, hormone sensitive type)
B: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
C: carboxyl ester lipase pseudogene (homo sapiens) (aka carboxyl ester lip... | [D; N; D] |
<Instruct>: Given the context 'This conclusion was confirmed by isolation and sequencing of the cDNA for human pancreatic cholesterol esterase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pancreatic cholesterol esterase]
<Options>: A: carboxyl ester lipase (homo sapiens) (aka carboxyl ester lipase)
B: carboxyl ester lipase (sus scrofa) (aka carboxyl ester lipase)
C: carboxyl ester lipase (oryctolagus cuniculus) (aka carboxyl ester lipase)
D: lipase e, hormone sensitive type (oryctolagus cun... | [A] |
<Instruct>: Given the context 'Analysis of the sequence for the human cholesterol esterase/milk lipase revealed similarities to other serine esterases in three distinct regions of the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [cholesterol esterase; milk lipase]
<Options>: A: pancreatic triacylglycerol lipase-like (gallus gallus) (aka pancreatic triacylglycerol lipase-like)
B: carboxylesterase 1 (oryctolagus cuniculus) (aka carboxylesterase 1)
C: cocaine esterase (oryctolagus cuniculus) (loc127491327 (oryctolagus cuniculus)) (aka... | [D; D] |
<Instruct>: Given the context 'Analysis of the sequence for the human cholesterol esterase/milk lipase revealed similarities to other serine esterases in three distinct regions of the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [cholesterol esterase; milk lipase]
<Options>: A: carboxylesterase 1 (oryctolagus cuniculus) (aka carboxylesterase 1)
B: carboxylesterase 1 (homo sapiens) (aka carboxylesterase 1)
C: monoglyceride lipase (gallus gallus) (aka monoglyceride lipase)
D: lipase h (bos taurus) (aka lipase h)
E: carboxyl ester lip... | [E; E] |
<Instruct>: Given the context 'Complete primary structure of the E1 beta subunit of human branched chain alpha-ketoacid dehydrogenase complex deduced from the nucleotide sequence and a gene analysis of patients with this disease.
', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [e1 beta subunit]
<Options>: A: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
B: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
C: e1b (homo sapiens) (branched chain keto acid dehydrogenase e1 s... | [C] |
<Instruct>: Given the context 'A defect in the E1 beta subunit of the branched chain alpha-ketoacid dehydrogenase (BCKDH) complex is one cause of maple syrup urine disease (MSUD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [e1 beta subunit]
<Options>: A: pdhe1b (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
B: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
C: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain ... | [E] |
<Instruct>: Given the context 'A defect in the E1 beta subunit of the branched chain alpha-ketoacid dehydrogenase (BCKDH) complex is one cause of maple syrup urine disease (MSUD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [e1 beta subunit]
<Options>: A: pyruvate dehydrogenase e1 subunit beta (oryctolagus cuniculus) (aka pyruvate dehydrogenase e1 subunit beta)
B: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
C: branched chain keto aci... | [E] |
<Instruct>: Given the context 'In an attempt to elucidate the molecular basis of MSUD, we isolated and characterized a 1.35 kbp cDNA clone encoding the entire precursor of the E1 beta subunit of BCKDH complex from a human placental cDNA library.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [e1 beta subunit]
<Options>: A: e1b (homo sapiens) (branched chain keto acid dehydrogenase e1 subunit beta (homo sapiens)) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
C: pyruvate dehyd... | [A] |
<Instruct>: Given the context 'Nucleotide sequence analysis revealed that the isolated cDNA clone (lambda hBE1 beta-1) contained a 5'-untranslated sequence of four nucleotides, the translated sequence of 1,176 nucleotides and the 3'-untranslated sequence of 169 nucleotides.', select the correct biomedical concept for e... | <Mentions>: [hbe1 beta-1]
<Options>: A: hemoglobin subunit beta pseudogene 1 (homo sapiens) (aka hemoglobin subunit beta pseudogene 1)
B: sodium voltage-gated channel beta subunit 1 (homo sapiens) (aka sodium voltage-gated channel beta subunit 1)
C: cholinergic receptor nicotinic beta 1 subunit (homo sapiens) (aka chol... | [F] |
<Instruct>: Given the context 'Comparison of the amino acid sequence predicted from the nucleotide sequence of the cDNA insert of the clone with the NH2-terminal amino acid sequence of the purified mature bovine BCKDH-E1 beta subunit showed that the cDNA insert encodes for a 342-amino acid subunit with a Mr = 37,585.',... | <Mentions>: [bckdh-e1 beta subunit]
<Options>: A: pdhe1-b (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
B: bckde1b (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
C: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydroge... | [D] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: branched chain ketoacid dehydrogenase e1, beta polypeptide (mus musculus) (aka branched chain ketoacid dehydrogenase e1, beta polypeptide)
B: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
C: pyruvate... | [J; M; J] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: pyruvate dehydrogenase e1 subunit beta (homo sapiens) (aka pyruvate dehydrogenase e1 subunit beta)
B: bckde1b (homo sapiens) (aka branched chain keto acid dehydrogenase e1 subunit beta)
C: e1c (homo sapiens) (aka small nucleolar rna, h/aca box 73b)
D: ... | [J; M; J] |
<Instruct>: Given the context 'A search for protein homology revealed that the primary structure of human BCKDH-E1 beta was similar to the bovine BCKDH-E1 beta and to the E1 beta subunit of human pyruvate dehydrogenase complex, in all regions.', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [e1 beta; bckdh-e1 beta; e1 beta subunit]
<Options>: A: branched chain keto acid dehydrogenase e1 subunit beta (sus scrofa) (aka branched chain keto acid dehydrogenase e1 subunit beta)
B: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
C: branched chai... | [G; K; G] |
<Instruct>: Given the context 'Genomic DNA from lymphoblastoid cell lines derived from normal and five MSUD patients, in whom E1 beta was not detected by immunoblot analysis, gave the same restriction maps on Southern blot analysis.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [e1 beta]
<Options>: A: e1c (homo sapiens) (aka small nucleolar rna, h/aca box 73b)
B: pyruvate dehydrogenase e1 subunit beta (rattus norvegicus) (aka pyruvate dehydrogenase e1 subunit beta)
C: branched chain keto acid dehydrogenase e1 subunit beta (rattus norvegicus) (aka branched chain keto acid dehydroge... | [D] |
<Instruct>: Given the context 'Sequence and expression of a human type II mesothelial keratin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type ii mesothelial keratin]
<Options>: A: krt2-3 (mus musculus) (aka keratin 84)
B: krt2-1 (mus musculus) (aka keratin 1)
C: keratin 2 (homo sapiens) (aka keratin 2)
D: krt1-2 (mus musculus) (aka keratin 32)
E: keratin 2 (mus musculus) (aka keratin 2)
F: None of the above. | [F] |
<Instruct>: Given the context 'A cloned cDNA encoding keratin K7 (55 kD) was identified by positive hybrid selection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [k7]
<Options>: A: krt7 (mus musculus) (aka keratin 7)
B: k6a (mus musculus) (aka keratin 6a)
C: k9 (mus musculus) (aka keratin 9)
D: k7 (homo sapiens) (keratin 7 (homo sapiens)) (aka keratin 7)
E: k8 (mus musculus) (aka keratin 8)
F: None of the above. | [D] |
<Instruct>: Given the context 'Southern Blot analysis indicated that this sequence is represented only once in the human genome, and Northern Blot analysis demonstrated that the gene encoding K7 is expressed in abundance in cultured bronchial and mesothelial cells, but only weakly in cultured epidermal cells and not at... | <Mentions>: [k7]
<Options>: A: k9 (mus musculus) (aka keratin 9)
B: k6a (mus musculus) (aka keratin 6a)
C: k7 (homo sapiens) (keratin 7 (homo sapiens)) (aka keratin 7)
D: k6 (mus musculus) (aka keratin 6)
E: k8 (mus musculus) (aka keratin 8)
F: None of the above. | [C] |
<Instruct>: Given the context 'The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells: whereas all of the epidermal type II keratins thus far sequenced have long nonhelical termini rich in glycine and serine, this m... | <Mentions>: [mesothelial type ii keratin]
<Options>: A: krt-2 (mus musculus) (aka keratin 1 complex)
B: krt2 (mus musculus) (keratin 2 (mus musculus)) (aka keratin 2)
C: krt222 (mus musculus) (aka keratin 222)
D: keratin 2 (homo sapiens) (aka keratin 2)
E: krt-2.6 (mus musculus) (aka keratin 6)
F: None of the above. | [F] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: map97 (homo sapiens) (aka melanotransferrin)
B: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
C: melanotransferrin (rattus norvegicus) (aka melanotransferrin)
D: (vcp)/p97 (drosophila melanogaster) (aka ... | [A; A; A] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: melanotransferrin (rattus norvegicus) (aka melanotransferrin)
B: melanotransferrin (mus musculus) (aka melanotransferrin)
C: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
D: (vcp)/p97 (d... | [L; L; L] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: melanotransferrin (gallus gallus) (aka melanotransferrin)
B: cep97 (homo sapiens) (aka centrosomal protein 97)
C: melanotransferrin (mus musculus) (aka melanotransferrin)
D: p97 (bos taurus) (aka valosin containing protein)
E: hspc97 (h... | [H; H; H] |
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.
p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept for each... | <Mentions>: [melanoma-associated antigen p97; melanotransferrin; p97]
<Options>: A: cep97 (homo sapiens) (aka centrosomal protein 97)
B: melanotransferrin (mus musculus) (aka melanotransferrin)
C: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
D: melanotransferrin (oryctolagus cuniculus) (aka melanotrans... | [L; L; L] |
<Instruct>: Given the context 'To determine the structure of this tumor-associated antigen and to identify its functional domains, we have purified and cloned p97 mRNA and determined its nucleotide sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97]
<Options>: A: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
B: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
C: p97 (bos taurus) (aka valosin containing protein)
D: map97 (homo sapiens) (aka melanotransferrin)
E: hspc9... | [D] |
<Instruct>: Given the context 'The mRNA encodes a 738-residue precursor, which contains the previously determined N-terminal amino acid sequence of p97.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [p97]
<Options>: A: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
B: p97 (bos taurus) (aka valosin containing protein)
C: map97 (homo sapiens) (aka melanotransferrin)
D: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
E: (vcp)/p97 (drosophila m... | [C] |
<Instruct>: Given the context 'After removal of a 19-residue signal peptide, the mature p97 molecule comprises extracellular domains of 342 and 352 residues and a C-terminal 25-residue stretch of predominantly uncharged and hydrophobic amino acids, which we believe acts as a membrane anchor.', select the correct biomed... | <Mentions>: [p97]
<Options>: A: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: map97 (homo sapiens) (aka melanotransferrin)
D: hspc97 (ho... | [C] |
<Instruct>: Given the context 'Protease digestion studies show that the three major antigenic determinants of p97 are present on the N-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [p97]
<Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: map97 (homo sapiens) (aka melanotransferrin)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: p97 (droso... | [B] |
<Instruct>: Given the context 'Protease digestion studies show that the three major antigenic determinants of p97 are present on the N-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [p97]
<Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
C: p97 (drosophila melanogaster) (regulatory particle non-atp... | [E] |
<Instruct>: Given the context 'The domains are strikingly homologous to each other (46% amino acid sequence homology) and to the corresponding domains of human serum transferrin (39% homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [transferrin]
<Options>: A: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
B: transferrin receptor (gallus gallus) (aka transferrin receptor)
C: tfr1 (homo sapiens) (aka transferrin receptor)
D: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin)
E: t... | [D] |
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [p97; transferrin]
<Options>: A: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
B: tfrc (gallus gallus) (aka transferrin receptor)
C: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
D: map97 (homo sapiens) (aka melanotransferrin)
E: tf (ho... | [D; E] |
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [p97; transferrin]
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
B: map97 (homo sapiens) (aka melanotransferrin)
C: transferrin receptor (homo sapiens) (aka transferrin receptor)
D: transferrin receptor (gallus gallus) (aka transferrin receptor)
E: tf (drosophila melanogaster) ... | [B; H] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin)
B: transferrin (sus scrofa) (aka transferrin)
C: p97 (bos taurus) (aka valosin containing protein)
D: lactotransferrin (homo sapiens) (aka lactotransferrin)
E: melanotra... | [I; I; A; D] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: melanotransferrin (gallus gallus) (aka melanotransferrin)
B: melanotransferrin (mus musculus) (aka melanotransferrin)
C: melanotransferrin (bos taurus) (aka melanotransferrin)
D: melanotransferrin (oryctolagus cuniculus) (aka melanotr... | [F; F; Q; H] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: lactotransferrin (mus musculus) (aka lactotransferrin)
B: melanotransferrin (rattus norvegicus) (aka melanotransferrin)
C: melanotransferrin (mus musculus) (aka melanotransferrin)
D: hspc197 (homo sapiens) (aka bet1 golgi vesicular me... | [S; S; P; N] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [p97; melanotransferrin; serotransferrin; lactotransferrin]
<Options>: A: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
B: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog)
C: lactoferrin (xenopu... | [L; L; O; Q] |
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept for each mention us... | <Mentions>: [transferrin]
<Options>: A: tfr (homo sapiens) (aka transferrin receptor)
B: tfrc (gallus gallus) (aka transferrin receptor)
C: transferrin (homo sapiens) (aka transferrin)
D: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1)
E: transferrin (ovotransferrin) (gallus g... | [C] |
<Instruct>: Given the context 'Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [calcineurin b]
<Options>: A: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha)
B: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
C: ppp3cb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta)
D: prkcbb (xenopus tropicalis) (aka pro... | [A] |
<Instruct>: Given the context 'We have identified and cloned human cDNA for the Ca2+-binding subunit of calcineurin, the brain isozyme of the Ca2+/calmodulin-stimulated protein phosphatase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [ca2+-binding subunit of calcineurin]
<Options>: A: cngb1 (xenopus tropicalis) (aka cyclic nucleotide gated channel beta 1)
B: calna1 (homo sapiens) (aka protein phosphatase 3 catalytic subunit alpha)
C: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1b)
D: cngb1 (homo sapiens) (aka c... | [E] |
<Instruct>: Given the context 'The deduced sequence of the human protein differs from bovine brain calcineurin B by an additional valine at the carboxyl terminus and substitution of Met-11 and Ser-153 by cysteine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [calcineurin b]
<Options>: A: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
B: can (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b)
C: protein phosphatase 3 regulatory subunit b, beta (homo sapiens) (aka protein phosphatase 3 regu... | [D] |
<Instruct>: Given the context 'As was observed with protein levels, mRNA abundance in brain is 20-60 times that found in other tissues with the exception of HeLa cells which, like brain, contain abundant calcineurin B mRNA.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [calcineurin b]
<Options>: A: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha)
B: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit)
C: protein phosphatase 3 regulatory subunit b, beta (homo sapiens) (aka protein phosphatase 3 regulatory subunit b,... | [A] |
<Instruct>: Given the context 'Human liver serine dehydratase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like)
B: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
C: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase)
D: serine dehydratase (xenopu... | [C] |
<Instruct>: Given the context 'Rat liver serine dehydratase cDNA was used to screen a human liver cDNA library in lambda gt11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (oryctolagus cuniculus) (aka serine dehydratase)
B: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
C: serine dehydratase like (homo sapiens) (aka serine dehydratase like)
D: serine dehydratase like (bos taurus) (aka se... | [F] |
<Instruct>: Given the context 'The deduced amino acid sequence, with a calculated Mr of 34,615, was similar to that of rat liver serine dehydratase except for the absence of a segment consisting of 36 amino acid residues.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (oryctolagus cuniculus) (aka serine dehydratase)
B: serine dehydratase (sus scrofa) (aka serine dehydratase)
C: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
D: sds (homo sapiens) (serine dehydratase (homo sapiens)) (... | [F] |
<Instruct>: Given the context 'In vitro transcription/translation with the cDNA resulted in the formation of a polypeptide with an Mr of approximately 35,000, which cross-reacted with the anti-rat serine dehydratase antibody.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [serine dehydratase]
<Options>: A: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase)
B: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog)
C: serine dehydratase (sus scrofa) (aka serine dehydratase)
D: serine dehydratase like (homo sapiens) (aka ... | [F] |
<Instruct>: Given the context 'These results suggest that the human serine dehydratase is structurally cognate with the rat enzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serine dehydratase]
<Options>: A: serine dehydratase (bos taurus) (aka serine dehydratase)
B: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase)
C: serine dehydratase like (bos taurus) (aka serine dehydratase like)
D: serine dehydratase s homeolog (xenopus laevis) (aka serine d... | [B] |
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [rac1; rac2]
<Options>: A: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
B: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene... | [E; H] |
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [rac1; rac2]
<Options>: A: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
B: rac (homo sapiens) (aka akt serine/threonine kinase 1)
C: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
D: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
E: r... | [J; G] |
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [rac1; rac2]
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
B: rac1 (homo sapiens) (rac family small gtpase 1 (homo sapiens)) (aka rac family small gtpase 1)
C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
D: rac1l (rattus norvegicus) (aka... | [B; I] |
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [rac1; rac2]
<Options>: A: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
B: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
D: akt2 (homo sapiens) (aka akt serine/threonine ki... | [H; F] |
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [rac1; rac2]
<Options>: A: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1)
D: rac-1 (homo sapiens) (aka rac family small gtpase 1)
E: rach... | [D; H] |
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [rac1; rac2]
<Options>: A: rac (homo sapiens) (aka akt serine/threonine kinase 1)
B: rac2 (homo sapiens) (aka rac family small gtpase 2)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
E: rac-b... | [I; B] |
<Instruct>: Given the context 'The rac transcripts, particularly rac2, display relative myeloid tissue selectivity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac2]
<Options>: A: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
C: rac (homo sapiens) (aka akt serine/threonine kinase 1)
D: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
E: p21-rac2 (... | [E] |
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