instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Both rac1 transcripts (2.4 and 1.1 kilobases (kb] increase when HL-60 cells differentiate to neutrophil-like morphology.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [rac1]
<Options>: A: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
B: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac-1 (homo sapiens) (aka rac family small gtpase 1)
E... | [D] |
<Instruct>: Given the context 'rac2 mRNA (1.45 kb) increases 7-9-fold and 3-fold upon differentiation of HL-60 and U937 cells, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rac2]
<Options>: A: p21-rac2 (homo sapiens) (aka rac family small gtpase 2)
B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
C: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
E: ra... | [A] |
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [rac1; rac2]
<Options>: A: p21-rac2 (homo sapiens) (aka rac family small gtpase 2)
B: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
D: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster))... | [I; A] |
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [rac1; rac2]
<Options>: A: rac family small gtpase 2 (homo sapiens) (aka rac family small gtpase 2)
B: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2)
D: rac1l (rattus norvegicus) (aka rac family s... | [I; A] |
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [rac1; rac2]
<Options>: A: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2)
C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
D: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
E: p21... | [E; J] |
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [rac1; rac2]
<Options>: A: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
B: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like)
C: rac (homo sapiens) (aka akt serine/threonine kinase 1)
D: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2)
E: rac gtpase (drosophila m... | [F; G] |
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [rac1; rac2]
<Options>: A: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1)
B: rac (homo sapiens) (aka akt serine/threonine kinase 1)
C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group))
D: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase ... | [D; G] |
<Instruct>: Given the context 'Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [cathepsin e]
<Options>: A: ctse (homo sapiens) (aka cathepsin e)
B: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
C: cathepsin e (rattus norvegicus) (aka cathepsin e)
D: cathepsin e (mus musculus) (aka cathepsin e)
E: cathepsin e (gallus gallus) (aka cathepsin e)
F: None of the above. | [A] |
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [cathepsin e; ctse]
<Options>: A: ctse (gallus gallus) (aka cathepsin e)
B: ctse (homo sapiens) (aka cathepsin e)
C: ctsh (homo sapiens) (aka cathepsin h)
D: cathepsin e (mus musculus) (aka cathepsin e)
E: ctse (rattus norvegicus) (aka cathepsin e)
F: cathepsin e (gallus gallus) (aka cathepsin e)
G: catheps... | [B; B] |
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [cathepsin e; ctse]
<Options>: A: cathepsin e (homo sapiens) (aka cathepsin e)
B: cathepsin c (homo sapiens) (aka cathepsin c)
C: cathepsin e (rattus norvegicus) (aka cathepsin e)
D: ctsa (homo sapiens) (aka cathepsin a)
E: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s h... | [A; A] |
<Instruct>: Given the context 'The CTSE cDNA clones were identified using a set of complementary 18-base oligonucleotide probes specific for a 6-residue sequence surrounding the first active site of all previously characterized human aspartic proteinases.', select the correct biomedical concept for each mention using t... | <Mentions>: [ctse]
<Options>: A: ctse (mus musculus) (aka cathepsin e)
B: ctse (gallus gallus) (aka cathepsin e)
C: ctsl (homo sapiens) (aka cathepsin l)
D: ctse (homo sapiens) (aka cathepsin e)
E: ctsh (homo sapiens) (aka cathepsin h)
F: None of the above. | [D] |
<Instruct>: Given the context 'The CTSE cDNA clones were identified using a set of complementary 18-base oligonucleotide probes specific for a 6-residue sequence surrounding the first active site of all previously characterized human aspartic proteinases.', select the correct biomedical concept for each mention using t... | <Mentions>: [ctse]
<Options>: A: ctse (gallus gallus) (aka cathepsin e)
B: ctsl (homo sapiens) (aka cathepsin l)
C: ctse (mus musculus) (aka cathepsin e)
D: ctsh (homo sapiens) (aka cathepsin h)
E: None of the above. | [E] |
<Instruct>: Given the context 'Sequence analysis of CTSE cDNA clones revealed a 1188-base pair open reading frame that exhibited 59% sequence identity with human pepsinogen A.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [ctse]
<Options>: A: ctse (mus musculus) (aka cathepsin e)
B: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
C: ctsa (homo sapiens) (aka cathepsin a)
D: ctsh (homo sapiens) (aka cathepsin h)
E: ctse (homo sapiens) (aka cathepsin e)
F: None of the above. | [E] |
<Instruct>: Given the context 'The predicted CTSE amino acid sequence includes a 379-residue proenzyme (Mr = 40,883) and a 17-residue signal peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: ctse (homo sapiens) (aka cathepsin e)
C: ctsl (homo sapiens) (aka cathepsin l)
D: ctse (rattus norvegicus) (aka cathepsin e)
E: ctse (mus musculus) (aka cathepsin e)
F: None of the above. | [B] |
<Instruct>: Given the context 'The predicted CTSE amino acid composition was consistent with that of purified material from gastric mucosa and gastric adenocarcinoma cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ctse]
<Options>: A: ctsh (homo sapiens) (aka cathepsin h)
B: ctse (homo sapiens) (aka cathepsin e)
C: ctse (rattus norvegicus) (aka cathepsin e)
D: ctse (gallus gallus) (aka cathepsin e)
E: ctsl (homo sapiens) (aka cathepsin l)
F: None of the above. | [B] |
<Instruct>: Given the context 'Additional evidence for the identification of the CTSE cDNA clones was obtained by analysis of poly(A+) RNA isolated from CTSE-producing and -nonproducing gastric adenocarcinoma cell subclones.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [ctse]
<Options>: A: ctse (homo sapiens) (aka cathepsin e)
B: ctsa (homo sapiens) (aka cathepsin a)
C: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
D: ctse (gallus gallus) (aka cathepsin e)
E: ctsl (homo sapiens) (aka cathepsin l)
F: None of the above. | [A] |
<Instruct>: Given the context 'Three RNA transcripts (3.6, 2.6, and 2.1 kilobases) were identified in poly(A+) RNA isolated from a gastric adenocarcinoma cell line that produced CTSE that were absent from nonproducing subclones.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [ctse]
<Options>: A: ctse (mus musculus) (aka cathepsin e)
B: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
C: ctse (rattus norvegicus) (aka cathepsin e)
D: ctse (homo sapiens) (aka cathepsin e)
E: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
F: N... | [D] |
<Instruct>: Given the context 'CTSE contains 7 cysteine residues, of which 6 were localized by comparative maximal alignment analysis with pepsinogen A to conserved residues that form intrachain disulfide bonds.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: ctsh (homo sapiens) (aka cathepsin h)
C: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
D: ctse (rattus norvegicus) (aka cathepsin e)
E: cathepsin e (homo sapiens) (aka cathepsin e)
F: None of the abo... | [E] |
<Instruct>: Given the context 'The seventh cysteine residue of CTSE is located within the activation peptide region of the proenzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ctse]
<Options>: A: ctsa (homo sapiens) (aka cathepsin a)
B: ctsl (homo sapiens) (aka cathepsin l)
C: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
D: ctse (mus musculus) (aka cathepsin e)
E: ctse (homo sapiens) (aka cathepsin e)
F: None of the above. | [E] |
<Instruct>: Given the context 'We suspect that this residue forms an interchain disulfide bond and thereby determines the dimerization of CTSE proenzyme molecules that is observed under native conditions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [ctse]
<Options>: A: ctsl (homo sapiens) (aka cathepsin l)
B: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
C: ctsh (homo sapiens) (aka cathepsin h)
D: ctsa (homo sapiens) (aka cathepsin a)
E: ctse (homo sapiens) (aka cathepsin e)
F: None of the above. | [E] |
<Instruct>: Given the context 'The CTSE gene was localized to human chromosome 1 by concurrent cytogenetic and cDNA probe analyses of a panel of human x mouse somatic cell hybrids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [ctse]
<Options>: A: ctse (rattus norvegicus) (aka cathepsin e)
B: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
C: cathepsin e (homo sapiens) (aka cathepsin e)
D: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog)
E: ctsl (homo sapiens) (aka cathepsin ... | [C] |
<Instruct>: Given the context 'Homology between a region of the human retinoblastoma gene and L1 family repetitive sequences.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoblastoma]
<Options>: A: rb3 (homo sapiens) (aka stathmin 4)
B: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2)
C: rb (homo sapiens) (aka rb transcriptional corepressor 1)
D: rbb (homo sapiens) (aka nacc family member 2)
E:... | [C] |
<Instruct>: Given the context 'Homology between a region of the human retinoblastoma gene and L1 family repetitive sequences.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [retinoblastoma]
<Options>: A: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2)
B: rb3 (homo sapiens) (aka stathmin 4)
C: rbb (homo sapiens) (aka nacc family member 2)
D: rb (drosophila melanogaster) (retinoblastoma-family protein... | [E] |
<Instruct>: Given the context 'Five clones that hybridized weakly with the human retinoblastoma (Rb) gene were obtained by screening a human genomic library in a non-stringent condition.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [retinoblastoma; rb]
<Options>: A: rbb (homo sapiens) (aka nacc family member 2)
B: rb-1 (homo sapiens) (aka rna binding motif protein 45)
C: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1)
D: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2)
E: rb (drosophila melanogaster) (ret... | [H; H] |
<Instruct>: Given the context 'Five clones that hybridized weakly with the human retinoblastoma (Rb) gene were obtained by screening a human genomic library in a non-stringent condition.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [retinoblastoma; rb]
<Options>: A: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2)
B: rb-1 (homo sapiens) (aka rna binding motif protein 45)
C: rb1 (homo sapiens) (aka rb transcriptional corepressor 1)
D: rb3 (homo sapiens) (aka stathmin 4)
E: rbl1 (homo sapiens) (aka rb transcriptional corep... | [C; C] |
<Instruct>: Given the context 'The DNAs of two of these clones were partially sequenced and found to contain a region with considerable homology to part of the Rb gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [rb]
<Options>: A: rb-1 (homo sapiens) (aka rna binding motif protein 45)
B: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1)
C: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein)
D: rb3 (homo sapiens) (aka stathmin 4)
E:... | [E] |
<Instruct>: Given the context 'As the L1 family is transposable, the Rb gene may be inactivated by recombination at this homologous region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rb]
<Options>: A: rb3 (homo sapiens) (aka stathmin 4)
B: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein)
C: p105-rb (homo sapiens) (aka rb transcriptional corepressor 1)
D: rbb (homo sapiens) (aka nacc family member 2)
E: rb2 (homo ... | [C] |
<Instruct>: Given the context 'Another possibility related with the DNA binding properties of Rb and L1 family proteins is also discussed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rb]
<Options>: A: prb (homo sapiens) (aka rb transcriptional corepressor 1)
B: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1)
C: rb3 (homo sapiens) (aka stathmin 4)
D: rb-1 (homo sapiens) (aka rna binding motif protein 45)
E: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2)
F... | [A] |
<Instruct>: Given the context 'COUP transcription factor is a member of the steroid receptor superfamily.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [coup transcription factor]
<Options>: A: coup-tfi (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 1)
B: coup (xenopus laevis) (nuclear receptor subfamily 2, group f, member 5 s homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2, group f, member 5 s homeolog)
C: coup-tf (bos ... | [E] |
<Instruct>: Given the context 'The COUP (chicken ovalbumin upstream promoter) transcription factor (COUP-TF) exists in a number of different tissues and is essential for expression of the chicken ovalbumin gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [coup (chicken ovalbumin upstream promoter) transcription factor; coup-tf]
<Options>: A: couptfb (homo sapiens) (aka nuclear receptor subfamily 2 group f member 2)
B: coup1 (xenopus laevis) (nuclear receptor subfamily 2 group f member 2 s homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2 group f ... | [E; E] |
<Instruct>: Given the context 'The COUP (chicken ovalbumin upstream promoter) transcription factor (COUP-TF) exists in a number of different tissues and is essential for expression of the chicken ovalbumin gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [coup (chicken ovalbumin upstream promoter) transcription factor; coup-tf]
<Options>: A: coup-tfi (rattus norvegicus) (aka nuclear receptor subfamily 2, group f, member 1)
B: coup-tfii (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 2)
C: coup-tfi (xenopus tropicalis) (aka nuclear rece... | [I; I] |
<Instruct>: Given the context 'The COUP (chicken ovalbumin upstream promoter) transcription factor (COUP-TF) exists in a number of different tissues and is essential for expression of the chicken ovalbumin gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [coup (chicken ovalbumin upstream promoter) transcription factor; coup-tf]
<Options>: A: coup-tfa (xenopus tropicalis) (aka nuclear receptor subfamily 2, group f, member 5)
B: couptf1 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 1)
C: coup-tfii (xenopus tropicalis) (aka nuclear receptor s... | [B; B] |
<Instruct>: Given the context 'COUP-TF also binds specifically to the rat insulin promoter element, although the two binding sites share little sequence similarity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [coup-tf]
<Options>: A: coup (xenopus laevis) (nuclear receptor subfamily 2, group f, member 5 l homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2, group f, member 5 l homeolog)
B: coup-tfi (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 1)
C: coup-tfii (xenopus tropicalis) ... | [D] |
<Instruct>: Given the context 'Here we report the isolation of a human complementary DNA clone encoding COUP-TF.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [coup-tf]
<Options>: A: coup-tfi (bos taurus) (aka nuclear receptor subfamily 2 group f member 1)
B: coup-tfi (rattus norvegicus) (aka nuclear receptor subfamily 2, group f, member 1)
C: coup-tfii (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 2)
D: coup (xenopus laevis) (nuclear rece... | [E] |
<Instruct>: Given the context 'Comparison of the amino-acid sequence of COUP-TF with known sequences reveals that it is a member of the steroid/thyroid hormone/vitamin receptor superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [coup-tf]
<Options>: A: coup (xenopus laevis) (nuclear receptor subfamily 2, group f, member 5 l homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2, group f, member 5 l homeolog)
B: couptfb (homo sapiens) (aka nuclear receptor subfamily 2 group f member 2)
C: coup-tfi (rattus norvegicus) (aka nucl... | [E] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [interleukin-2 receptor beta; interleukin-2; il-2; il-2 receptor alpha]
<Options>: A: il22 (homo sapiens) (aka interleukin 22)
B: il-2 (homo sapiens) (aka interleukin 2)
C: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta)
D: interleukin 1 receptor type 2 (homo sap... | [C; B; B; I] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [interleukin-2 receptor beta; interleukin-2; il-2; il-2 receptor alpha]
<Options>: A: colony stimulating factor 2 receptor subunit beta (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta)
B: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2)
C: il2ra (homo sa... | [F; I; I; C] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [interleukin-2 receptor beta; interleukin-2; il-2; il-2 receptor alpha]
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2)
C: csf2rb (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta)
D: ... | [P; D; D; G] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [interleukin-2 receptor beta; interleukin-2; il-2; il-2 receptor alpha]
<Options>: A: csf2 (homo sapiens) (aka colony stimulating factor 2)
B: interleukin 3 (homo sapiens) (aka interleukin 3)
C: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
D: il12rb (homo ... | [G; I; I; K] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [il-2r alpha; p55; il-2 receptor beta; il-2r beta]
<Options>: A: il22r (homo sapiens) (aka interleukin 22 receptor subunit alpha 1)
B: pp565 (homo sapiens) (aka pp565)
C: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1)
D: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin... | [L; L; D; D] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [il-2r alpha; p55; il-2 receptor beta; il-2r beta]
<Options>: A: csf2rb (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta)
B: csf2rb2 (homo sapiens) (aka csf2rb pseudogene 1)
C: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta)
D: il-2rg (homo sapiens) (aka interleukin 2 rec... | [I; I; C; C] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [il-2r alpha; p55; il-2 receptor beta; il-2r beta]
<Options>: A: interleukin 12 receptor subunit beta 2 (homo sapiens) (aka interleukin 12 receptor subunit beta 2)
B: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma)
C: pp565 (homo sapiens) (aka pp565)
D: il2rb (homo sapiens) (aka interleukin... | [N; N; D; D] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [il-2r alpha; p55; il-2 receptor beta; il-2r beta]
<Options>: A: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2)
B: cd132 (homo sapiens) (aka interleukin 2 receptor subunit gamma)
C: il12rb2 (homo sapiens) (aka interleukin 12 receptor subunit beta 2)
D: il2r (homo sapiens) (... | [D; D; P; P] |
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, ... | <Mentions>: [p70-75]
<Options>: A: ck-75 (homo sapiens) (aka keratin 75)
B: hsp 75 (homo sapiens) (aka tnf receptor associated protein 1)
C: pp75 (homo sapiens) (aka rab11 family interacting protein 5)
D: p70-75 (homo sapiens) (aka interleukin 2 receptor subunit beta)
E: rpl7ap75 (homo sapiens) (aka ribosomal protein l... | [D] |
<Instruct>: Given the context 'The cDNA encoding the human IL-2R beta chain has now been isolated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-2r beta]
<Options>: A: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta)
B: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1)
C: il2r (homo sapiens) (aka interleukin 2 receptor subunit alpha)
D: interleukin 12 receptor subunit beta 2 (homo sapiens) (aka interleukin 12 recep... | [A] |
<Instruct>: Given the context 'The overall primary structure of the IL-2R beta chain shows no apparent homology to other known receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-2r beta]
<Options>: A: csf2rb2 (homo sapiens) (aka csf2rb pseudogene 1)
B: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta)
C: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma)
D: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1)
E: il2r (homo sapiens) (aka ... | [B] |
<Instruct>: Given the context 'The overall primary structure of the IL-2R beta chain shows no apparent homology to other known receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-2r beta]
<Options>: A: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma)
B: il2r (homo sapiens) (aka interleukin 2 receptor subunit alpha)
C: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1)
D: csf2rb2 (homo sapiens) (aka csf2rb pseudogene 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'Unlike the IL-2R alpha chain, the IL-2R beta chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [il-2r alpha; il-2r beta]
<Options>: A: il2r (homo sapiens) (aka interleukin 2 receptor subunit alpha)
B: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2)
C: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma)
D: il2rb (homo sapiens) (aka interleukin 2 receptor s... | [H; D] |
<Instruct>: Given the context 'Unlike the IL-2R alpha chain, the IL-2R beta chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [il-2r alpha; il-2r beta]
<Options>: A: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma)
B: colony stimulating factor 2 receptor subunit alpha (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha)
C: csf2rb2 (homo sapiens) (aka csf2rb pseudogen... | [D; H] |
<Instruct>: Given the context 'The cDNA-encoded beta chain binds and internalizes IL-2 when expressed on T lymphoid cells but not fibroblast cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-2]
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3)
B: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
C: il22 (homo sapiens) (aka interleukin 22)
D: interleukin 2 (homo sapiens) (aka interleukin 2)
E: csf2 (homo sapiens) (aka colony stimulating factor 2)
F: None of the abo... | [D] |
<Instruct>: Given the context 'Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [il-2 receptor; il-2r alpha]
<Options>: A: colony stimulating factor 2 receptor subunit beta (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta)
B: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta)
C: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 recep... | [B; D] |
<Instruct>: Given the context 'Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [il-2 receptor; il-2r alpha]
<Options>: A: interleukin 2 receptor subunit alpha (homo sapiens) (aka interleukin 2 receptor subunit alpha)
B: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma)
C: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta)
D: interleukin 2 receptor subunit ga... | [G; E] |
<Instruct>: Given the context 'Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ldl receptor]
<Options>: A: very low density lipoprotein receptor (gallus gallus) (aka very low density lipoprotein receptor)
B: ldl receptor related protein 1 (homo sapiens) (aka ldl receptor related protein 1)
C: ldlr (homo sapiens) (aka low density lipoprotein receptor)
D: oxidized low density lipoprote... | [C] |
<Instruct>: Given the context 'Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ldl receptor]
<Options>: A: low density lipoprotein receptor (sus scrofa) (aka low density lipoprotein receptor)
B: very low density lipoprotein receptor (gallus gallus) (aka very low density lipoprotein receptor)
C: ldl receptor related protein 1 (homo sapiens) (aka ldl receptor related protein 1)
D: oxid... | [E] |
<Instruct>: Given the context 'The pathogenesis of Heymann nephritis, a rat model of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [gp330]
<Options>: A: gp330 (xenopus tropicalis) (aka ldl receptor related protein 2)
B: gp280 (homo sapiens) (aka cubilin)
C: gp330 (homo sapiens) (aka ldl receptor related protein 2)
D: gp330 (mus musculus) (aka low density lipoprotein receptor-related protein 2)
E: gp43 (xenopus laevis) (provisional orth... | [C] |
<Instruct>: Given the context 'Partial complementary DNAs coding for GP330 were isolated and sequenced.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gp330]
<Options>: A: gp340 (homo sapiens) (aka deleted in malignant brain tumors 1)
B: gp330 (xenopus tropicalis) (aka ldl receptor related protein 2)
C: gp340 (xenopus laevis) (deleted in malignant brain tumors 1 l homeolog (xenopus laevis)) (aka deleted in malignant brain tumors 1 l homeolog)
D: gp280 (h... | [E] |
<Instruct>: Given the context 'The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [low density lipoprotein (ldl) receptor; gp330; ldl receptor]
<Options>: A: oxidized low density lipoprotein receptor 1 (homo sapiens) (aka oxidized low density lipoprotein receptor 1)
B: low density lipoprotein receptor (gallus gallus) (aka low density lipoprotein receptor)
C: apolipoprotein b receptor (ho... | [E; H; E] |
<Instruct>: Given the context 'The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [low density lipoprotein (ldl) receptor; gp330; ldl receptor]
<Options>: A: gp43 (xenopus laevis) (provisional ortholog of zona pellucida glycoprotein 3 s homeolog (xenopus laevis)) (aka provisional ortholog of zona pellucida glycoprotein 3 s homeolog)
B: ldl receptor related protein 1 (homo sapiens) (aka l... | [K; I; K] |
<Instruct>: Given the context 'The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [low density lipoprotein (ldl) receptor; gp330; ldl receptor]
<Options>: A: low density lipoprotein receptor (gallus gallus) (aka low density lipoprotein receptor)
B: gp340 (xenopus laevis) (deleted in malignant brain tumors 1 l homeolog (xenopus laevis)) (aka deleted in malignant brain tumors 1 l homeolog)... | [H; M; H] |
<Instruct>: Given the context 'Autoantibodies from the kidneys of rats with Heymann nephritis reacted with a nonglycosylated segment of GP330 that contains cysteine-rich 40-amino acid repeats, which are also features of the LDL receptor.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [gp330; ldl receptor]
<Options>: A: gp330 (homo sapiens) (aka ldl receptor related protein 2)
B: gp280 (homo sapiens) (aka cubilin)
C: gp330 (mus musculus) (aka low density lipoprotein receptor-related protein 2)
D: ldlr (homo sapiens) (aka low density lipoprotein receptor)
E: very low density lipoprotein r... | [A; D] |
<Instruct>: Given the context 'Autoantibodies from the kidneys of rats with Heymann nephritis reacted with a nonglycosylated segment of GP330 that contains cysteine-rich 40-amino acid repeats, which are also features of the LDL receptor.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [gp330; ldl receptor]
<Options>: A: low density lipoprotein receptor (sus scrofa) (aka low density lipoprotein receptor)
B: gp330 (mus musculus) (aka low density lipoprotein receptor-related protein 2)
C: very low density lipoprotein receptor (homo sapiens) (aka very low density lipoprotein receptor)
D: gp3... | [D; E] |
<Instruct>: Given the context 'GP330 is also similar in some regions to the mouse epidermal growth factor precursor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gp330]
<Options>: A: gp280 (homo sapiens) (aka cubilin)
B: gp330 (xenopus tropicalis) (aka ldl receptor related protein 2)
C: gp340 (xenopus laevis) (deleted in malignant brain tumors 1 s homeolog (xenopus laevis)) (aka deleted in malignant brain tumors 1 s homeolog)
D: gp43 (xenopus laevis) (provisional o... | [E] |
<Instruct>: Given the context 'Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mrna polyadenylate binding protein]
<Options>: A: polyadenylate-binding protein 1 (arabidopsis thaliana) (aka polyadenylate-binding protein 1)
B: polyadenylate-binding protein 5-like (glycine max) (aka polyadenylate-binding protein 5-like)
C: pabp1 (homo sapiens) (poly(a) binding protein cytoplasmic 1 (hom... | [C] |
<Instruct>: Given the context 'We have isolated a full length cDNA (cDNA) coding for the human poly(A) binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [poly(a) binding protein]
<Options>: A: poly(a) binding protein cytoplasmic 1 (homo sapiens) (aka poly(a) binding protein cytoplasmic 1)
B: poly(a) binding protein (drosophila melanogaster) (aka poly(a) binding protein)
C: polyadenylate-binding protein 1 (arabidopsis thaliana) (aka polyadenylate-binding pro... | [A] |
<Instruct>: Given the context 'The cDNA derived 73 kd basic translation product has the same Mr, isoelectric point and peptidic map as the poly(A) binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [poly(a) binding protein]
<Options>: A: poly(a) binding protein (drosophila melanogaster) (aka poly(a) binding protein)
B: polyadenylate-binding protein 1 (arabidopsis thaliana) (aka polyadenylate-binding protein 1)
C: poly(a) binding protein cytoplasmic 1 (homo sapiens) (aka poly(a) binding protein cytopla... | [C] |
<Instruct>: Given the context 'The N terminal part, highly homologous to the yeast poly(A) binding protein, is sufficient for poly(A) binding activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [poly(a) binding protein]
<Options>: A: poly(a) binding protein 1 (arabidopsis thaliana) (aka poly(a) binding protein 1)
B: poly(a) binding protein nuclear 1 (homo sapiens) (aka poly(a) binding protein nuclear 1)
C: poly(a) binding protein (drosophila melanogaster) (aka poly(a) binding protein)
D: poly(a)-b... | [E] |
<Instruct>: Given the context 'The N terminal part, highly homologous to the yeast poly(A) binding protein, is sufficient for poly(A) binding activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [poly(a) binding protein]
<Options>: A: poly(a) binding protein nuclear 1 (homo sapiens) (aka poly(a) binding protein nuclear 1)
B: poly(a)-binding protein (arabidopsis thaliana) (aka poly(a)-binding protein 5)
C: poly(a) binding protein (drosophila melanogaster) (aka poly(a) binding protein)
D: poly(a) bin... | [E] |
<Instruct>: Given the context 'Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c1; c8]
<Options>: A: c1in (homo sapiens) (aka serpin family g member 1)
B: m8 (drosophila melanogaster) (enhancer of split m8, helix-loop-helix (drosophila melanogaster)) (aka enhancer of split m8, helix-loop-helix)
C: a-c1 (homo sapiens) (aka phospholipase a and acyltransferase 1)
D: g8 (homo sapiens) (a... | [J; G] |
<Instruct>: Given the context 'Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c1; c8]
<Options>: A: c8a (homo sapiens) (aka complement c8 alpha chain)
B: complement c1r (homo sapiens) (aka complement c1r)
C: hho.c8 (homo sapiens) (aka homeobox c6)
D: homeobox c8 (homo sapiens) (aka homeobox c8)
E: c8c (homo sapiens) (aka complement c8 gamma chain)
F: hho.c1 (homo sapiens) (aka homeo... | [F; D] |
<Instruct>: Given the context 'Two human cDNA clones (HHO.c1.95 and HHO.c8.5111) containing a homeobox region have been characterized, and the respective genomic regions have been partially analyzed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [hho.c1; hho.c8]
<Options>: A: hoxc8 (homo sapiens) (aka homeobox c8)
B: hox8 (homo sapiens) (aka msh homeobox 2)
C: hoxc8 (xenopus laevis) (homeobox c8 s homeolog (xenopus laevis)) (aka homeobox c8 s homeolog)
D: host cell factor c1 (homo sapiens) (aka host cell factor c1)
E: hypoc1 (homo sapiens) (aka cal... | [J; A] |
<Instruct>: Given the context 'Two human cDNA clones (HHO.c1.95 and HHO.c8.5111) containing a homeobox region have been characterized, and the respective genomic regions have been partially analyzed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [hho.c1; hho.c8]
<Options>: A: hha8 (homo sapiens) (aka keratin 38)
B: hhc1 (homo sapiens) (aka calcium sensing receptor)
C: o8 (homo sapiens) (aka immunoglobulin kappa variable 1d-33)
D: coh1 (homo sapiens) (aka vacuolar protein sorting 13 homolog b)
E: hoxc8 (xenopus laevis) (homeobox c8 s homeolog (xenop... | [J; G] |
<Instruct>: Given the context 'Expression of the corresponding genes, termed c1 and c8, was evaluated in different organs and body parts during human embryonic/fetal development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [c1; c8]
<Options>: A: hoxc8 (xenopus laevis) (homeobox c8 s homeolog (xenopus laevis)) (aka homeobox c8 s homeolog)
B: host cell factor c1 (bos taurus) (aka host cell factor c1)
C: m8 (drosophila melanogaster) (enhancer of split m8, helix-loop-helix (drosophila melanogaster)) (aka enhancer of split m8, hel... | [D; F] |
<Instruct>: Given the context 'Expression of the corresponding genes, termed c1 and c8, was evaluated in different organs and body parts during human embryonic/fetal development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [c1; c8]
<Options>: A: m8 (drosophila melanogaster) (enhancer of split m8, helix-loop-helix (drosophila melanogaster)) (aka enhancer of split m8, helix-loop-helix)
B: c1_a (homo sapiens) (aka endogenous retrovirus group k member 1)
C: scg8 (homo sapiens) (aka proprotein convertase subtilisin/kexin type 1 in... | [J; G] |
<Instruct>: Given the context 'Expression of the corresponding genes, termed c1 and c8, was evaluated in different organs and body parts during human embryonic/fetal development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [c1; c8]
<Options>: A: hoxc8 (xenopus laevis) (homeobox c8 s homeolog (xenopus laevis)) (aka homeobox c8 s homeolog)
B: c1s (homo sapiens) (aka complement c1s)
C: m8 (homo sapiens) (aka prion locus lncrna, testis expressed)
D: complement c1r (homo sapiens) (aka complement c1r)
E: c1in (homo sapiens) (aka se... | [J; H] |
<Instruct>: Given the context 'HHO.c1.95 apparently encodes a 217-amino acid protein containing a class I homeodomain that shares 60 out of 61 amino acid residues with the Antennapedia homeodomain of Drosophila melanogaster. HHO.c8.5111', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [hho.c1; hho.c8]
<Options>: A: one cut homeobox 1 (homo sapiens) (aka one cut homeobox 1)
B: hoxc8 (xenopus laevis) (homeobox c8 s homeolog (xenopus laevis)) (aka homeobox c8 s homeolog)
C: hho.c8 (homo sapiens) (aka homeobox c6)
D: host cell factor c1 (homo sapiens) (aka host cell factor c1)
E: hho.c1 (hom... | [E; I] |
<Instruct>: Given the context 'HHO.c1.95 apparently encodes a 217-amino acid protein containing a class I homeodomain that shares 60 out of 61 amino acid residues with the Antennapedia homeodomain of Drosophila melanogaster. HHO.c8.5111', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [hho.c1; hho.c8]
<Options>: A: coh1 (homo sapiens) (aka vacuolar protein sorting 13 homolog b)
B: hypoc1 (homo sapiens) (aka calcium sensing receptor)
C: ch1 (homo sapiens) (aka sun domain containing ossification factor)
D: hoxc8 (xenopus laevis) (homeobox c8 s homeolog (xenopus laevis)) (aka homeobox c8 s ... | [I; F] |
<Instruct>: Given the context 'encodes a 153-amino acid protein containing a homeodomain identical to that of the frog AC1 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ac1]
<Options>: A: aconitate decarboxylase 1 (homo sapiens) (aka aconitate decarboxylase 1)
B: ach1 (homo sapiens) (aka acyl-coa thioesterase 7)
C: acc-1 (homo sapiens) (aka bcl2 related protein a1)
D: adenylate cyclase 1 (homo sapiens) (aka adenylate cyclase 1)
E: an1 (homo sapiens) (aka paired box 6)
F: ... | [F] |
<Instruct>: Given the context 'Clones HHO.c1 and HHO.c8 detect by blot-hydridization one and two specific polyadenylylated transcripts, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hho.c1; hho.c8]
<Options>: A: hha8 (homo sapiens) (aka keratin 38)
B: ch1 (homo sapiens) (aka sun domain containing ossification factor)
C: c8c (homo sapiens) (aka complement c8 gamma chain)
D: hho.c1 (homo sapiens) (aka homeobox b7)
E: one cut homeobox 1 (homo sapiens) (aka one cut homeobox 1)
F: hoxc8 (h... | [D; F] |
<Instruct>: Given the context 'Clones HHO.c1 and HHO.c8 detect by blot-hydridization one and two specific polyadenylylated transcripts, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hho.c1; hho.c8]
<Options>: A: hho.c1 (homo sapiens) (aka homeobox b7)
B: c8c (homo sapiens) (aka complement c8 gamma chain)
C: ch1 (homo sapiens) (aka sun domain containing ossification factor)
D: hha8 (homo sapiens) (aka keratin 38)
E: a-c1 (homo sapiens) (aka phospholipase a and acyltransferase 1)
F: hc1... | [A; G] |
<Instruct>: Given the context 'These are differentially expressed in spinal cord, backbone rudiments, limb buds (or limbs), heart, and skin of human embryos and early fetuses in the 5- to 9-week postfertilization period, thus suggesting that the c1 and c8 genes play a key role in a variety of developmental processes.',... | <Mentions>: [c1; c8]
<Options>: A: hho.c1 (homo sapiens) (aka homeobox b7)
B: c1in (homo sapiens) (aka serpin family g member 1)
C: a-c1 (homo sapiens) (aka phospholipase a and acyltransferase 1)
D: c8g (homo sapiens) (aka complement c8 gamma chain)
E: c1_c (homo sapiens) (aka endogenous retrovirus group k member 18)
F... | [A; F] |
<Instruct>: Given the context 'These are differentially expressed in spinal cord, backbone rudiments, limb buds (or limbs), heart, and skin of human embryos and early fetuses in the 5- to 9-week postfertilization period, thus suggesting that the c1 and c8 genes play a key role in a variety of developmental processes.',... | <Mentions>: [c1; c8]
<Options>: A: c8g (homo sapiens) (aka complement c8 gamma chain)
B: host cell factor c1 (bos taurus) (aka host cell factor c1)
C: c1nh (homo sapiens) (aka serpin family g member 1)
D: hho.c1 (homo sapiens) (aka homeobox b7)
E: c1_c (homo sapiens) (aka endogenous retrovirus group k member 18)
F: scg... | [D; H] |
<Instruct>: Given the context 'Together, the results of the embryonic/fetal expression of c1 and c8 and those of two previously analyzed genes (c10 and c13) indicate a coherent pattern of expression of these genes in early human ontogeny.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [c1; c8; c10; c13]
<Options>: A: c10 (homo sapiens) (aka chromosome 12 open reading frame 57)
B: host cell factor c1 (bos taurus) (aka host cell factor c1)
C: hoxc8 (xenopus laevis) (homeobox c8 s homeolog (xenopus laevis)) (aka homeobox c8 s homeolog)
D: homeobox c8 (homo sapiens) (aka homeobox c8)
E: o13 ... | [L; D; S; M] |
<Instruct>: Given the context 'Together, the results of the embryonic/fetal expression of c1 and c8 and those of two previously analyzed genes (c10 and c13) indicate a coherent pattern of expression of these genes in early human ontogeny.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [c1; c8; c10; c13]
<Options>: A: m8 (homo sapiens) (aka prion locus lncrna, testis expressed)
B: sc13 (homo sapiens) (aka cystatin 11)
C: homeobox c10 (homo sapiens) (aka homeobox c10)
D: carbonic anhydrase 13 (homo sapiens) (aka carbonic anhydrase 13)
E: m8 (drosophila melanogaster) (enhancer of split m8, ... | [P; R; C; J] |
<Instruct>: Given the context 'Together, the results of the embryonic/fetal expression of c1 and c8 and those of two previously analyzed genes (c10 and c13) indicate a coherent pattern of expression of these genes in early human ontogeny.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [c1; c8; c10; c13]
<Options>: A: c10_a (homo sapiens) (aka endogenous retrovirus group k member 16)
B: g8 (homo sapiens) (aka small nucleolar rna host gene 32)
C: hho.c10 (homo sapiens) (aka homeobox b5)
D: host cell factor c1 (bos taurus) (aka host cell factor c1)
E: c13 (homo sapiens) (aka spt20 homolog, ... | [N; T; M; I] |
<Instruct>: Given the context 'Together, the results of the embryonic/fetal expression of c1 and c8 and those of two previously analyzed genes (c10 and c13) indicate a coherent pattern of expression of these genes in early human ontogeny.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [c1; c8; c10; c13]
<Options>: A: hho.c13 (homo sapiens) (aka homeobox d4)
B: homeobox c10 (homo sapiens) (aka homeobox c10)
C: homeobox c8 (homo sapiens) (aka homeobox c8)
D: hho.c1 (homo sapiens) (aka homeobox b7)
E: gene rich cluster, c10 gene (danio rerio) (aka gene rich cluster, c10 gene)
F: scg8 (homo ... | [D; C; B; S] |
<Instruct>: Given the context 'Studies of the human c-myb gene and its product in human acute leukemias.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-myb]
<Options>: A: myb (homo sapiens) (aka myb proto-oncogene, transcription factor)
B: b-myb (homo sapiens) (aka myb proto-oncogene like 2)
C: b-myb (mus musculus) (aka myeloblastosis oncogene-like 2)
D: myb proto-oncogene like 1 (homo sapiens) (aka myb proto-oncogene like 1)
E: c-myb (mus musculus) (ak... | [A] |
<Instruct>: Given the context 'The myb gene is the transforming oncogene of the avian myeloblastosis virus (AMV); its normal cellular homolog, c-myb, is conserved across a broad span of evolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [myb; c-myb]
<Options>: A: b-myb (mus musculus) (aka myeloblastosis oncogene-like 2)
B: v-myb avian myeloblastosis viral oncogene homolog (danio rerio) (aka v-myb avian myeloblastosis viral oncogene homolog)
C: myb proto-oncogene like 1 (homo sapiens) (aka myb proto-oncogene like 1)
D: b-myb (homo sapiens) ... | [G; G] |
<Instruct>: Given the context 'The myb gene is the transforming oncogene of the avian myeloblastosis virus (AMV); its normal cellular homolog, c-myb, is conserved across a broad span of evolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [myb; c-myb]
<Options>: A: myb (drosophila melanogaster) (aka myb oncogene-like)
B: b-myb (homo sapiens) (aka myb proto-oncogene like 2)
C: myb-1a (mus musculus) (aka y box protein 1)
D: c-myb (mus musculus) (aka myeloblastosis oncogene)
E: v-myb avian myeloblastosis viral oncogene homolog (danio rerio) (ak... | [H; H] |
<Instruct>: Given the context 'In humans, c-myb is expressed in malignant hematopoietic cell lines and in primary hematopoietic tumors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-myb]
<Options>: A: mybp-c (homo sapiens) (aka myosin binding protein c3)
B: b-myb (homo sapiens) (aka myb proto-oncogene like 2)
C: c-myb (homo sapiens) (aka myb proto-oncogene, transcription factor)
D: a-myb (homo sapiens) (aka myb proto-oncogene like 1)
E: b-myb (mus musculus) (aka myeloblastosis oncog... | [C] |
<Instruct>: Given the context 'The sequences of the clones were compared to the c-myb of other species, as well as the v-myb of AMV.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-myb; v-myb]
<Options>: A: myb (homo sapiens) (aka myb proto-oncogene, transcription factor)
B: c-myb (mus musculus) (aka myeloblastosis oncogene)
C: b-myb (homo sapiens) (aka myb proto-oncogene like 2)
D: a-myb (homo sapiens) (aka myb proto-oncogene like 1)
E: v-myb avian myeloblastosis viral oncogene ho... | [A; A] |
<Instruct>: Given the context 'The sequences of the clones were compared to the c-myb of other species, as well as the v-myb of AMV.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-myb; v-myb]
<Options>: A: a-myb (homo sapiens) (aka myb proto-oncogene like 1)
B: b-myb (homo sapiens) (aka myb proto-oncogene like 2)
C: myb proto-oncogene, transcription factor (gallus gallus) (aka myb proto-oncogene, transcription factor)
D: c-myb (homo sapiens) (aka myb proto-oncogene, transcription ... | [D; D] |
<Instruct>: Given the context 'In addition, the carboxyl terminal region of human c-myb was placed in an expression vector to obtain protein for the generation of antiserum, which was used to identify the human c-myb gene product.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [c-myb]
<Options>: A: b-myb (homo sapiens) (aka myb proto-oncogene like 2)
B: myb (homo sapiens) (aka myb proto-oncogene, transcription factor)
C: myb proto-oncogene like 1 (homo sapiens) (aka myb proto-oncogene like 1)
D: myb (mus musculus) (aka myeloblastosis oncogene)
E: mybp-c (homo sapiens) (aka myosin... | [B] |
<Instruct>: Given the context 'Like v-myb, this protein was found within the nucleus of leukemic cells where it was associated with the nuclear matrix.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [v-myb]
<Options>: A: c-myb (homo sapiens) (aka myb proto-oncogene, transcription factor)
B: b-myb (homo sapiens) (aka myb proto-oncogene like 2)
C: a-myb (homo sapiens) (aka myb proto-oncogene like 1)
D: myb (mus musculus) (aka myeloblastosis oncogene)
E: b-myb (mus musculus) (aka myeloblastosis oncogene-l... | [A] |
<Instruct>: Given the context 'These studies provide further evidence that c-myb might be involved in human leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-myb]
<Options>: A: myb (mus musculus) (aka myeloblastosis oncogene)
B: myb proto-oncogene like 1 (homo sapiens) (aka myb proto-oncogene like 1)
C: mybp-c (homo sapiens) (aka myosin binding protein c3)
D: c-myb (homo sapiens) (aka myb proto-oncogene, transcription factor)
E: b-myb (homo sapiens) (aka myb ... | [D] |
<Instruct>: Given the context 'Human creatine kinase: isolation and sequence analysis of cDNA clones for the B subunit, development of subunit specific probes and determination of gene copy number.
cDNA clones for human B creatine kinase were isolated from human brain and placenta libraries.', select the correct biomed... | <Mentions>: [b creatine kinase]
<Options>: A: creatine kinase, muscle b (danio rerio) (aka creatine kinase, muscle b)
B: ckb (homo sapiens) (creatine kinase b (homo sapiens)) (aka creatine kinase b)
C: ckb (bos taurus) (aka creatine kinase b)
D: creatine kinase b (rattus norvegicus) (aka creatine kinase b)
E: creatine ... | [B] |
<Instruct>: Given the context 'A 77.7% nucleotide sequence identity was found between the coding region of human B creatine kinase and our previously reported human M creatine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [b creatine kinase; m creatine kinase]
<Options>: A: creatine kinase, muscle (mus musculus) (aka creatine kinase, muscle)
B: creatine kinase b (sus scrofa) (aka creatine kinase b)
C: creatine kinase, brain (mus musculus) (aka creatine kinase, brain)
D: cpk-m (mus musculus) (aka phosphatidylinositol-4-phosph... | [F; H] |
<Instruct>: Given the context 'A 77.7% nucleotide sequence identity was found between the coding region of human B creatine kinase and our previously reported human M creatine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [b creatine kinase; m creatine kinase]
<Options>: A: creatine kinase b (gallus gallus) (aka creatine kinase b)
B: creatine kinase, m-type (homo sapiens) (aka creatine kinase, m-type)
C: ckb (bos taurus) (aka creatine kinase b)
D: cpk-m (mus musculus) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic ... | [F; B] |
<Instruct>: Given the context 'Southern transfers of total genomic DNA derived from human placenta and digested to completion with several restriction enzymes were probed with the MCK and BCK specific probes producing single hybridization bands.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [mck; bck]
<Options>: A: cpk-m (mus musculus) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
B: serine/threonine/tyrosine protein kinase mck1 (saccharomyces cerevisiae s288c) (aka serine/threonine/tyrosine protein kinase mck1)
C: prkcb (bos taurus) (aka protein kinase c beta)... | [K; D] |
<Instruct>: Given the context 'Southern transfers of total genomic DNA derived from human placenta and digested to completion with several restriction enzymes were probed with the MCK and BCK specific probes producing single hybridization bands.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [mck; bck]
<Options>: A: blk (homo sapiens) (aka blk proto-oncogene, src family tyrosine kinase)
B: prkcb (bos taurus) (aka protein kinase c beta)
C: ccnk (mus musculus) (aka cyclin k)
D: mcak (mus musculus) (aka kinesin family member 2c)
E: creatine kinase b (bos taurus) (aka creatine kinase b)
F: serine/t... | [K; H] |
<Instruct>: Given the context 'Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [dna polymerase delta]
<Options>: A: dna polymerase delta 2, accessory subunit (homo sapiens) (aka dna polymerase delta 2, accessory subunit)
B: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
C: dna polymerase lambda (homo sapiens) (aka dna polymeras... | [B] |
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