instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Soluble Apo-2L induces extensive apoptosis in lymphoid as well as non-lymphoid tumor cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l]
<Options>: A: tall-2 (homo sapiens) (aka tnf superfamily member 13)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: apo-2l (homo sapiens) (aka tnf superfamily member 10)
D: cd95-l (homo sapiens) (aka fas ligand)
E: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
F: None of ... | [C] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: trail (homo sapiens) (aka tnf superfamily member 10)
B: apol2 (homo sapiens) (aka apolipoprotein l2)
C: apo-1 (homo sapiens) (aka fas cell surface death receptor)
D: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
E: fas activated serine/threonine kinase (homo sa... | [A; G; O] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
B: apo2l (homo sapiens) (aka tnf superfamily member 10)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: cd95l (homo sapiens) (aka fas ligand)
E: tall-2 (hom... | [B; A; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
C: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
D: fas activated serine/threonine kinase (homo sapiens) (aka... | [M; E; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: apo-1 (homo sapiens) (aka fas cell surface death receptor)
B: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
C: cd95-l (homo sapiens) (aka fas ligand)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: fas (gallus gallus) (aka fas cell surface dea... | [O; J; L] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
B: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: fasps (homo sapiens) (aka period circadian regulator 2)
E: fast (homo sapi... | [P; J; F] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: apo-1 (homo sapiens) (aka fas cell surface death receptor)
B: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
C: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
D: apo2l (homo sapie... | [P; B; D] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fasas (homo sapiens) (aka fas antisense rna 1)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: apol-i (homo sapiens) (aka apolipoprotein l1)
E: fas activated serine/threonine kinase (homo sapiens) (aka... | [I; L; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: apol1 (homo sapiens) (aka apolipoprotein l1)
B: fas (gallus gallus) (aka fas cell surface death receptor)
C: apo-1 (homo sapiens) (aka fas cell surface death receptor)
D: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
E: trail (homo sapiens) (aka tnf superfa... | [F; J; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: cd95l (homo sapiens) (aka fas ligand)
B: fas (gallus gallus) (aka fas cell surface death receptor)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
E: apol2 (homo sapiens) (aka apolipoprotein l2)
F: fasas ... | [C; N; O] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: cd95l (homo sapiens) (aka fas ligand)
B: fasas (homo sapiens) (aka fas antisense rna 1)
C: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
D: apo-1 (homo sapiens) (aka fas cell surface death receptor)
E: apoop1 (homo sapiens) (aka apolipoprotein o pseudoge... | [F; N; N] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: fasas (homo sapiens) (aka fas antisense rna 1)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: apol1 (homo sapiens) (aka apolipoprotein l1)
E: fasps (homo sapiens) (aka period circadian regulator 2)
F: ... | [N; N; H] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: cd95l (homo sapiens) (aka fas ligand)
B: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
C: apo2l (homo sapiens) (aka tnf superfamily member 10)
D: cd40 ligand (homo sapiens) (aka cd40 ligand)
E:... | [J; J; C] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: apo2l (homo sapiens) (aka tnf superfamily member 10)
B: fas-as (homo sapiens) (aka fas antisense rna 1)
C: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
D: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface deat... | [D; D; A] |
<Instruct>: Given the context 'Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [polypeptide n-acetylgalactosaminyltransferase, galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminylt... | [C] |
<Instruct>: Given the context 'Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [polypeptide n-acetylgalactosaminyltransferase, galnac-t3]
<Options>: A: b4galnt3 (homo sapiens) (aka beta-1,4-n-acetyl-galactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminylt... | [E] |
<Instruct>: Given the context 'Here we report the cDNA cloning and expression of a novel GalNAc-transferase termed GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:po... | [E] |
<Instruct>: Given the context 'The overall amino acid sequence similarity with GalNAc-T1 and -T2 is approximately 45%; 12 cysteine residues that are shared between GalNAc-T1 and -T2 are also found in GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (bos taurus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:polypeptide n-a... | [C] |
<Instruct>: Given the context 'GalNAc-T3 was expressed as a soluble protein without the hydrophobic transmembrane domain in insect cells using a Baculo-virus vector, and the expressed GalNAc-transferase activity showed substrate specificity different from that previously reported for GalNAc-T1 and -T2.', select the cor... | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 6, gene 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 6, gene 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: udp-n-acetyl-alpha-... | [E] |
<Instruct>: Given the context 'Northern analysis of human organs revealed a very restricted expression pattern of GalNAc-T3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [galnac-t3]
<Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka pol... | [B] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
B: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic translation initiation fact... | [F; F; F] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eif-5a (homo sapiens) (eukaryotic translation initiation factor 5 (homo sapiens)) (aka eukaryotic translation initiation factor 5)
B: eif5 (drosophila melanogaster) (eukaryotic translation initiation... | [A; A; A] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eukaryotic translation initiation factor 5a (homo sapiens) (aka eukaryotic translation initiation factor 5a)
B: eukaryotic translation initiation factor 4e-5 (caenorhabditis elegans) (aka eukaryotic ... | [G; G; G] |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining... | <Mentions>: [mammalian translation initiation factor 5; eif-5; eukaryotic translation initiation factor 5]
<Options>: A: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
B: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
C: eu... | [B; B; B] |
<Instruct>: Given the context 'In this paper, the multiple mRNAs that encode mammalian eIF-5 have been characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
C: eif-5 (homo sapiens) (aka eukaryotic translation initiatio... | [C] |
<Instruct>: Given the context 'In rat tissues, three major eIF-5 mRNAs of 3.5, 2.8, and 2.2 kilobases in length are detected.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eif5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
C: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation fa... | [A] |
<Instruct>: Given the context 'All major eIF-5 mRNAs are initiated from a single transcription initiation site, contain identical 5'-untranslated and coding regions, but differ from one another only in the length of their 3'-untranslated regions.', select the correct biomedical concept for each mention using the provid... | <Mentions>: [eif-5]
<Options>: A: eif-5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (mus musculus) (... | [A] |
<Instruct>: Given the context 'The different lengths of the 3'-untranslated region of eIF-5 mRNAs are generated by the use of alternative polyadenylation signals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
C: translation initiation factor eif5 (saccharomyces cerevisiae... | [E] |
<Instruct>: Given the context 'Additionally, we demonstrate tissue-specific variations in eIF-5 mRNA expression as well as preference for polyadenylation sites.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [eif-5]
<Options>: A: eif5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
C: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
D: eukaryotic tran... | [A] |
<Instruct>: Given the context 'These results should lead to increased understanding of the regulation of eIF-5 gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-5]
<Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
C: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic tran... | [A] |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: granzyme b (rattus norvegicus) (aka granzyme b)
B: granzyme b (bos taurus) (aka granzyme b)
C: granzyme b (homo sapiens) (aka granzyme b)
D: granzyme b (oryctolagus cuniculus) (aka granzyme b)
E: cathepsin b (homo sapiens) (aka cathepsin b)
F: ice-lap6 (homo sapiens) (ak... | [F; C] |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: ice-lap6 (mus musculus) (aka caspase 9)
B: caspase 6 (homo sapiens) (aka caspase 6)
C: granzyme b (oryctolagus cuniculus) (aka granzyme b)
D: granzyme b (rattus norvegicus) (aka granzyme b)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: ice-lap6 (xenopus tropicalis) (aka ... | [E; G] |
<Instruct>: Given the context 'Here, we characterize a novel member of this family designated ICE-LAP6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ice-lap6]
<Options>: A: casp-7 (homo sapiens) (aka caspase 7)
B: casp-8 (homo sapiens) (aka caspase 8)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: ice-lap6 (mus musculus) (aka caspase 9)
E: caspase-6 (homo sapiens) (aka caspase 6)
F: None of the above. | [C] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: pp32 (homo sapiens) (aka acidic nuclear phosphoprotein 32 family member a)
B: casp-8 (homo sapiens) (aka caspase 8)
C: caspase-6 (homo sapiens) (aka caspase 6)
D: cuta (homo sapiens) (aka cuta divalent cation tolerance homolog)
E: yam1 (homo sapiens) (aka yy1-a... | [H; L; L; L] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: chica (homo sapiens) (aka family with sequence similarity 83 member d)
B: casp-8 (homo sapiens) (aka caspase 8)
C: ice-lap6 (mus musculus) (aka caspase 9)
D: drosophila executioner caspase related to apopain/yama (drosophila melanogaster) (aka death executioner... | [O; N; N; N] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: chica (homo sapiens) (aka family with sequence similarity 83 member d)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: hcp32 (homo sapiens) (aka cycs pseudogene 32)
D: aponp (homo sapiens) (aka apolipoprotein n, pseudogene)
E: ice-lap6 (mus musculus) (... | [Q; F; F; F] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: apop1 (homo sapiens) (aka cytochrome c oxidase assembly factor 8)
B: pp32 (homo sapiens) (aka acidic nuclear phosphoprotein 32 family member a)
C: hcp32 (homo sapiens) (aka cycs pseudogene 32)
D: apol (homo sapiens) (aka apolipoprotein l1)
E: yam1 (homo sapiens... | [R; M; M; M] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [ice-lap6; yama; cpp32; apopain]
<Options>: A: spgf32 (homo sapiens) (aka spermatogenesis and oogenesis specific basic helix-loop-helix 1)
B: yam1 (homo sapiens) (aka yy1-associated myogenesis rna 1)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: hcp32 (homo sapiens) (aka cycs pseudogene 32)
E: cuta (homo sa... | [C; T; T; T] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: transient receptor potential cation channel subfamily c member 3 (homo sapiens) (aka transient receptor potential cation channel subfamily c member 3)
B: mcp3 (homo sapiens) (aka c-c motif chemokine ligand 7)
C: ich-3 (homo sapiens) (aka caspase 5)
D: hcam-1 (homo... | [Q; G; G; G] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: mch4 (homo sapiens) (aka caspase 10)
B: caspase 3 (homo sapiens) (aka caspase 3)
C: hmcn2 (homo sapiens) (aka hemicentin 2)
D: cmh1 (homo sapiens) (aka myosin heavy chain 7)
E: ligand-gated chloride channel homolog 3 (drosophila melanogaster) (aka ligand-gated chl... | [R; H; H; H] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: mcp3 (homo sapiens) (aka c-c motif chemokine ligand 7)
B: caspase 3 (drosophila melanogaster) (death related ice-like caspase (drosophila melanogaster)) (aka death related ice-like caspase)
C: mch4 (homo sapiens) (aka caspase 10)
D: caspase 3 (homo sapiens) (aka c... | [Q; E; E; E] |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [mch2; ice-lap3; mch3; cmh-1]
<Options>: A: ich-3 (homo sapiens) (aka caspase 5)
B: casp-7 (homo sapiens) (aka caspase 7)
C: hcam-1 (homo sapiens) (aka phosphodiesterase 1a)
D: cmh1 (homo sapiens) (aka myosin heavy chain 7)
E: mchr2 (homo sapiens) (aka melanin concentrating hormone receptor 2)
F: mch3 (homo... | [Q; B; B; B] |
<Instruct>: Given the context 'Interestingly, ICE-LAP6 contains an active site QACGG pentapeptide, rather than the QACRG pentapeptide shared by other family members.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [ice-lap6]
<Options>: A: ice-lap6 (homo sapiens) (aka caspase 9)
B: casp6 (homo sapiens) (aka caspase 6)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: casp-7 (homo sapiens) (aka caspase 7)
E: casp-8 (homo sapiens) (aka caspase 8)
F: None of the above. | [A] |
<Instruct>: Given the context 'Overexpression of ICE-LAP6 induces apoptosis in MCF7 breast carcinoma cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ice-lap6]
<Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: casp6 (homo sapiens) (aka caspase 6)
C: ice-lap3 (homo sapiens) (aka caspase 7)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: None of the above. | [E] |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: cathepsin b (homo sapiens) (aka cathepsin b)
B: ice-lap6 (xenopus tropicalis) (aka caspase 9)
C: granzyme b, pseudogene 2 (rattus norvegicus) (aka granzyme b, pseudogene 2)
D: granzyme b (homo sapiens) (aka granzyme b)
E: casp16 (homo sapiens) (aka caspase 16, pseudogene... | [I; D] |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: ice-lap6 (xenopus tropicalis) (aka caspase 9)
B: casp-7 (homo sapiens) (aka caspase 7)
C: granzyme b, pseudogene 2 (rattus norvegicus) (aka granzyme b, pseudogene 2)
D: granzyme b (homo sapiens) (aka granzyme b)
E: casp16 (homo sapiens) (aka caspase 16, pseudogene)
F: gr... | [J; D] |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [ice-lap6; granzyme b]
<Options>: A: granzyme b (mus musculus) (aka granzyme b)
B: granzyme h (homo sapiens) (aka granzyme h)
C: cathepsin b (homo sapiens) (aka cathepsin b)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: granzyme b (bos taurus) (aka granzyme b... | [E; I] |
<Instruct>: Given the context 'Once activated, ICE-LAP6 is able to cleave the death substrate poly(ADP-ribose) polymerase into signature apoptotic fragments.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [ice-lap6]
<Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: caspase-6 (homo sapiens) (aka caspase 6)
D: ice-lap6 (homo sapiens) (aka caspase 9)
E: ice-lap6 (mus musculus) (aka caspase 9)
F: None of the above. | [D] |
<Instruct>: Given the context 'Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cb2 (homo sapiens) (aka cannabinoid receptor 2)
E: g... | [F] |
<Instruct>: Given the context 'We have cloned the peripheral cannabinoid receptor, mCB2, from a mouse splenocyte cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mcb2]
<Options>: A: secretoglobin, family 2b, member 2 (mus musculus) (aka secretoglobin, family 2b, member 2)
B: bmch2 (mus musculus) (aka bone mechanical trait 2)
C: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
D: bmc2 (mus musculus) (aka bone mineral content 2)
E: mcop2 (homo sapiens) (a... | [F] |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept for ... | <Mentions>: [cb2; hcb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: cbc2 (homo sapiens) (aka nuclear cap binding protein subunit 2)... | [B; B] |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept for ... | <Mentions>: [cb2; hcb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: mopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
C: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
... | [I; I] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: cb1r (mus musculus) (aka cannabinoid receptor 1)
B: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
C: bmch2 (mus musculus) (aka bone mechanical trait 2)
D: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
E: mcop... | [N; N; L] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: cb1r (homo sapiens) (aka cannabinoid receptor 1)
B: cbc2 (homo sapiens) (aka nuclear cap binding protein subunit 2)
C: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
D: cb1r (mus musculus) (aka cannabinoid receptor 1)
E: mcopcb2 (homo sapiens) (... | [N; N; A] |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide an... | <Mentions>: [mcb2; hcb2; cb1]
<Options>: A: cb1 (homo sapiens) (aka cannabinoid receptor 1)
B: cb1a (mus musculus) (aka cannabinoid receptor 1)
C: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
D: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium a... | [N; N; A] |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [hcb2; mcb2]
<Options>: A: b cell maturation defect 2 (mus musculus) (aka b cell maturation defect 2)
B: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
C: mc2 (homo sapiens) (aka melanocortin 5 receptor)
D: cgb2 (homo sapiens) (aka chorionic gonadotropin subunit beta 2)
E: cbc... | [K; K] |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [hcb2; mcb2]
<Options>: A: secretoglobin, family 2b, member 2 (mus musculus) (aka secretoglobin, family 2b, member 2)
B: mcop2 (homo sapiens) (aka visual system homeobox 2)
C: hcr2 (homo sapiens) (aka dicarbonyl and l-xylulose reductase)
D: bmc2 (mus musculus) (aka bone mineral content 2)
E: csnb2b (homo sa... | [K; K] |
<Instruct>: Given the context 'SR 141716A failed to antagonize this activity in either cell line, confirming its specificity for CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1]
<Options>: A: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: cb1a (homo sapiens) (aka cannabinoid receptor 1)
C: cb1r (mus musculus) (aka cannabinoid receptor 1)
D: None of the above. | [B] |
<Instruct>: Given the context 'The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [glycine receptor beta]
<Options>: A: glycine receptor beta (bos taurus) (aka glycine receptor beta)
B: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
C: glycine receptor beta (xenopus tropicalis) (aka glycine receptor beta)
D: receptor for activated c kinase 1b (glycine max) (aka r... | [E] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
B: glyb (homo sapiens) (aka solute carrier family 25 member 32)
C: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
D: glycine receptor, alpha 1 (rat... | [C; C; A] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: gprc1b (homo sapiens) (aka glutamate metabotropic receptor 2)
C: glrb (homo sapiens) (aka glycine receptor beta)
D: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeol... | [C; C; G] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
D: gprg1b (homo sapiens) (aka ... | [L; L; I] |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with... | <Mentions>: [beta subunit of the human glyr; glyr beta; glyr alpha 1]
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
D: glrb (homo sapiens) (aka glyc... | [D; D; C] |
<Instruct>: Given the context 'Neither [3H]strychnine binding nor glycine-gated currents were detected when the human GlyR beta subunit cDNA was expressed in the human embryonic kidney 293 cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [glyr beta]
<Options>: A: glycine receptor beta (bos taurus) (aka glycine receptor beta)
B: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: glyci... | [E] |
<Instruct>: Given the context 'However, co-expression of the beta subunit cDNA with the alpha 1 subunit cDNA resulted in expression of functional GlyRs which showed a 4-fold reduction in the EC50 values when compared to alpha 1 homomeric GlyRs.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [alpha 1 homomeric glyrs]
<Options>: A: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
C: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopu... | [A] |
<Instruct>: Given the context 'Glycine-gated currents of alpha 1/beta GlyRs were 17-fold less sensitive than homomeric alpha 1 GlyRs to the antagonists picrotoxin, picrotoxinin and picrotin, providing clear evidence that heteromeric alpha 1/beta GlyRs were expressed.', select the correct biomedical concept for each men... | <Mentions>: [alpha 1 glyrs]
<Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
C: glycine receptor alpha 1 (sus scrofa) (aka glycine receptor alpha 1)
D: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
E: glyr-a1 (xenopu... | [D] |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [glyr beta; glrb]
<Options>: A: glrb (oryctolagus cuniculus) (aka glycine receptor beta)
B: gabrb1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit beta1)
C: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
D: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, bet... | [G; G] |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [glyr beta; glrb]
<Options>: A: gabrb1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit beta1)
B: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
C: glrb (homo sapiens) (aka glycine receptor beta)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E... | [C; C] |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [glyr beta; glrb]
<Options>: A: glrb (rattus norvegicus) (aka glycine receptor, beta)
B: glr (homo sapiens) (aka glycine receptor alpha 2)
C: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: glrb (xenopus tropicalis... | [I; I] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: spastic paraplegia 14 (autosomal recessive) (homo sapiens) (aka spastic paraplegia 14 (autosomal recessive))
B: spastic paraplegia 37 (autosomal dominant) (homo sapiens) (aka spastic paraplegia 37 (autosomal dominant))
C: glrb (mus musculus) (aka glycine receptor, be... | [L; C; C] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: glrb (homo sapiens) (aka glycine receptor beta)
B: hyperreflexia (homo sapiens) (aka hyperreflexia)
C: spn-4 (caenorhabditis elegans) (aka rrm domain-containing protein)
D: glr (homo sapiens) (aka glycine receptor alpha 2)
E: spastic paraplegia 7 (pure and complicate... | [A; J; J] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [glyr beta; glrb; spastic]
<Options>: A: gabrb1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit beta1)
B: spastic paraplegia 7 (pure and complicated autosomal recessive) (xenopus tropicalis) (aka spastic paraplegia 7 (pure and complicated autosomal recessive))
C: glycine receptor beta (s... | [J; D; D] |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [spa]
<Options>: A: spap1a (homo sapiens) (aka fc receptor like 2)
B: spax1 (homo sapiens) (aka vesicle associated membrane protein 1)
C: spam (homo sapiens) (aka eyes shut homolog)
D: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
E: spap (homo sapiens) (aka pdzk1 interactin... | [F] |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyr beta; spa]
<Options>: A: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
B: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
C: glycine receptor beta (bos taurus) (aka glycine receptor beta)
D: spast.s (xenopus laevis) (aka spastin s homeolog)
E: spax1 (homo sapiens) ... | [K; K] |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glyr beta; spa]
<Options>: A: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
B: spast.s (xenopus laevis) (aka spastin s homeolog)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: spalpha (homo sapiens) (aka cd5 molecule like)
E: spax1 (homo sapiens) (aka vesicle associated ... | [K; K] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
B: cdc26 (homo sapiens) (aka cell division cycle 26)
C: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
D: mcm dna helicase complex subunit mcm6 (saccharomyces cer... | [M; M; M] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
B: minichromosome maintenance complex component 5 (mus musculus) (aka minichromosome maintenance complex component 5)
C: mcm dna helicase complex subunit mcm5 (sac... | [E; E; E] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
B: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
C: minichromosome maintenance 5 (drosophila melanogaster) (aka minichromosome maintena... | [L; L; L] |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; hcdc46; mcm5]
<Options>: A: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
B: cdc26 (homo sapiens) (aka cell division cycle 26)
C: cdc5 (homo sapiens) (aka cell division cycle 5 like)
D: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphas... | [A; A; A] |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; mcm5]
<Options>: A: minichromosome maintenance 5 (drosophila melanogaster) (aka minichromosome maintenance 5)
B: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
C: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
D: minichromosome mainten... | [G; G] |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cdc46; mcm5]
<Options>: A: mcm dna helicase complex subunit mcm6 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm6)
B: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
C: mcm6 (homo sapiens) (aka minichromosome maintenance complex component 6)
D... | [H; H] |
<Instruct>: Given the context 'The cDNA was used as a probe for chromosomal fluorescence in situ hybridization (FISH), which localized the human Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cdc46]
<Options>: A: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
B: cdc16 (homo sapiens) (aka cell division cycle 16)
C: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
D: cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting compl... | [E] |
<Instruct>: Given the context 'As deduced from the cDNA sequence, human protein hCdc46 is composed of 734 amino acids and contains a central region that is almost 80% identical with the yeast protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [hcdc46]
<Options>: A: cell division cycle 26 (homo sapiens) (aka cell division cycle 26)
B: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
C: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: cdc6 (homo sapiens) (aka cell division cycle 6)
E: hcp26 (homo sapi... | [C] |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [hcdc46; p1mcm3]
<Options>: A: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
B: hcp26 (homo sapiens) (aka cycs pseudogene 26)
C: p1 (mus musculus) (minichromosome maintenance complex component 3 (mus musculus)) (aka minichromosome maintenance complex component 3)
D: p1-mcm3 (homo... | [A; D] |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [hcdc46; p1mcm3]
<Options>: A: p1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: cdc16 (homo sapiens) (aka cell division cycle 16)
C: chmp3 (mus musculus) (aka charged multivesicular body protein 3)
D: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
E: cdc46 ... | [E; A] |
<Instruct>: Given the context 'We report herein the presence of kappa opioid receptors (KORs) in human fetal microglia and inhibition of HIV-1 expression in acutely infected microglial cell cultures treated with KOR ligands.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [kor]
<Options>: A: kor (mus musculus) (aka opioid receptor, kappa 1)
B: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
D: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: oprk (homo sapiens) (aka opioid recep... | [E] |
<Instruct>: Given the context 'Using reverse transcriptase-polymerase chain reaction and sequencing analyses, we found that mRNA for the KOR was constitutively expressed in microglia and determined that the nucleotide sequence of the open reading frame was identical to that of the human brain KOR gene.', select the cor... | <Mentions>: [kor]
<Options>: A: kor (mus musculus) (aka opioid receptor, kappa 1)
B: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: kor (homo sapiens) (aka opioid receptor kappa 1)
D: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
E: kor3 (homo sapiens) (aka opioid related nociceptin ... | [C] |
<Instruct>: Given the context 'The expression of KOR in microglial cells was confirmed by membrane binding of [3H]U69,593, a kappa-selective ligand, and by indirect immunofluorescence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [kor]
<Options>: A: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: kor-1 (homo sapiens) (aka opioid receptor kappa 1)
C: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
D: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
E: kor (mus musculus) (aka opioid recep... | [B] |
<Instruct>: Given the context 'This antiviral effect of the kappa ligands was blocked by the specific KOR antagonist, nor-binaltrophimine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kor]
<Options>: A: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: kor (mus musculus) (aka opioid receptor, kappa 1)
C: oprk (homo sapiens) (aka opioid receptor kappa 1)
D: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: kor3 (homo sapiens) (aka opioid related nociceptin ... | [C] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: p-55 (homo sapiens) (aka peptidase, mitochondrial processing subunit alpha)
B: p97 (mus musculus) (valosin containing protein (mus musculus)) (aka valosin containing protein)
C: predicted gen... | [D; D; D] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: ct47.11 (homo sapiens) (aka cancer/testis antigen family 47 member a11)
B: p-55 (homo sapiens) (aka peptidase, mitochondrial processing subunit alpha)
C: p97 (mus musculus) (valosin containin... | [N; N; N] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: rp97 (homo sapiens) (aka von willebrand factor a domain containing 8)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subuni... | [B; B; B] |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p97 subunit of the 26s proteasome; type-1 tumor-necrosis-factor-receptor-associated protein-2; 55.11]
<Options>: A: tram2 (homo sapiens) (aka translocation associated membrane protein 2)
B: drada2 (homo sapiens) (aka adenosine deaminase rna specific b1)
C: rp97 (homo sapiens) (aka von willebrand factor a d... | [D; D; D] |
<Instruct>: Given the context 'Molecular cloning of cDNA for a new regulatory subunit, designated p97, of the human 26S proteasome showed that the polypeptide consists of 908 amino acid residues with a calculated molecular mass of 100184 Da and an isoelectric point of 4.94.', select the correct biomedical concept for e... | <Mentions>: [p97]
<Options>: A: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
B: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
C: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin ... | [D] |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the c... | <Mentions>: [p97; type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2]
<Options>: A: receptor accessory protein 2 (homo sapiens) (aka receptor accessory protein 2)
B: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
C: p97 (homo sapiens) (proteasome 26s... | [C; C] |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the c... | <Mentions>: [p97; type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2]
<Options>: A: trappc2 (homo sapiens) (aka trafficking protein particle complex subunit 2)
B: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
C: rna polymerase ii associated protein 2 (homo sapiens) (aka rna polymerase ii a... | [F; F] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: nop protein chaperone 1 (homo sapiens) (aka nop protein chaperone 1)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: p97 (drosophila melanogaster) (... | [B; I; I] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: map97 (homo sapiens) (aka melanotransferrin)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: nars (homo sapiens) (aka asparaginyl-trna synthetase 1)... | [B; F; F] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: proteasome 26s subunit, non-atpase 1 (homo sapiens) (aka proteasome 26s subunit, non-atpase 1)
B: nars (homo sapiens) (aka asparaginyl-trna synthetase 1)
C: nas1 (homo sapiens) (nr2f1 regulatory antisense rna 1 (homo sapiens)) (aka nr2f1 regulatory antisense r... | [M; J; J] |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [p97; nas1; non-atpase subunit 1]
<Options>: A: nas1 (homo sapiens) (nr2f1 regulatory antisense rna 1 (homo sapiens)) (aka nr2f1 regulatory antisense rna 1)
B: matrix non-peptidase homolog 1 (caenorhabditis elegans) (aka matrix non-peptidase homolog 1)
C: (vcp)/p97 (drosophila melanogaster) (aka transitiona... | [O; J; J] |
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